GMIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.81164757
2regulation of B cell receptor signaling pathway (GO:0050855)4.89796298
3negative regulation of cell killing (GO:0031342)4.89176171
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.89176171
5detection of other organism (GO:0098543)4.76798892
6detection of bacterium (GO:0016045)4.63911179
7positive regulation by symbiont of host defense response (GO:0052509)4.55646940
8modulation by symbiont of host defense response (GO:0052031)4.55646940
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.55646940
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.55646940
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.55646940
12modulation by symbiont of host immune response (GO:0052553)4.55646940
13leukocyte aggregation (GO:0070486)4.53082436
14antigen processing and presentation of endogenous antigen (GO:0019883)4.42352964
15B cell receptor signaling pathway (GO:0050853)4.33776136
16positive thymic T cell selection (GO:0045059)4.26493407
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26451814
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26451814
19regulation of interferon-beta biosynthetic process (GO:0045357)4.20497941
20neutrophil activation involved in immune response (GO:0002283)4.16329612
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.11031503
22response to peptidoglycan (GO:0032494)4.08309220
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03302028
24detection of external biotic stimulus (GO:0098581)4.01097539
25regulation of gamma-delta T cell activation (GO:0046643)3.98987345
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.95939949
27positive regulation of B cell differentiation (GO:0045579)3.95434870
28neutrophil activation (GO:0042119)3.94569400
29regulation of gamma-delta T cell differentiation (GO:0045586)3.93481254
30regulation of B cell differentiation (GO:0045577)3.90931976
31macrophage activation involved in immune response (GO:0002281)3.82879795
32negative thymic T cell selection (GO:0045060)3.81682108
33negative T cell selection (GO:0043383)3.80389890
34mature B cell differentiation (GO:0002335)3.79088634
35histone H3-K4 trimethylation (GO:0080182)3.77805616
36response to muramyl dipeptide (GO:0032495)3.76133314
37detection of molecule of bacterial origin (GO:0032490)3.75090635
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75026713
39respiratory burst (GO:0045730)3.68485460
40positive T cell selection (GO:0043368)3.68340262
41T cell migration (GO:0072678)3.67558305
42tolerance induction (GO:0002507)3.66577850
43granulocyte activation (GO:0036230)3.64915440
44immunoglobulin mediated immune response (GO:0016064)3.62100144
45cellular extravasation (GO:0045123)3.61970704
46negative regulation of erythrocyte differentiation (GO:0045647)3.61318268
47positive regulation of antigen processing and presentation (GO:0002579)3.60410317
48negative regulation of leukocyte mediated immunity (GO:0002704)3.59362462
49NIK/NF-kappaB signaling (GO:0038061)3.57616459
50negative regulation of T cell mediated immunity (GO:0002710)3.56496663
51detection of biotic stimulus (GO:0009595)3.51833257
52neutrophil mediated immunity (GO:0002446)3.47048631
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.45461846
54positive regulation of interferon-alpha production (GO:0032727)3.44541131
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.44418377
56interferon-gamma production (GO:0032609)3.42652973
57germinal center formation (GO:0002467)3.40262812
58thymic T cell selection (GO:0045061)3.33636522
59negative regulation of granulocyte differentiation (GO:0030853)3.32040939
60myeloid cell activation involved in immune response (GO:0002275)3.29653715
61regulation of interferon-alpha production (GO:0032647)3.28698660
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28563955
63T cell selection (GO:0045058)3.28080723
64response to interleukin-15 (GO:0070672)3.27748057
65B cell homeostasis (GO:0001782)3.27503530
66cellular response to interleukin-15 (GO:0071350)3.25306276
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24845373
68regulation of mast cell activation involved in immune response (GO:0033006)3.23515769
69leukocyte migration involved in inflammatory response (GO:0002523)3.22512588
70regulation of leukocyte degranulation (GO:0043300)3.22270202
71negative regulation of interleukin-12 production (GO:0032695)3.20421285
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20118674
73response to host immune response (GO:0052572)3.20118674
74B cell mediated immunity (GO:0019724)3.18396238
75production of molecular mediator involved in inflammatory response (GO:0002532)3.17939417
76regulation of tolerance induction (GO:0002643)3.16766170
77regulation of T cell tolerance induction (GO:0002664)3.16568532
78antigen receptor-mediated signaling pathway (GO:0050851)3.14876463
79regulation of antigen processing and presentation (GO:0002577)3.13445266
80antigen processing and presentation via MHC class Ib (GO:0002475)3.13382252
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11919379
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10786950
83regulation of T-helper 2 cell differentiation (GO:0045628)3.08287797
84defense response to protozoan (GO:0042832)3.07095710
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06512447
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04932300
87I-kappaB phosphorylation (GO:0007252)3.04893565
88activated T cell proliferation (GO:0050798)3.02861440
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99725623
90microglial cell activation (GO:0001774)2.98928680
91mature B cell differentiation involved in immune response (GO:0002313)2.98738274
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98491437
93leukocyte cell-cell adhesion (GO:0007159)2.97583842
94negative regulation of cytokine production involved in immune response (GO:0002719)2.96972517
95interferon-gamma-mediated signaling pathway (GO:0060333)2.95613371
96leukocyte degranulation (GO:0043299)2.94442127
97negative regulation of interleukin-6 production (GO:0032715)2.94076595
98negative regulation of innate immune response (GO:0045824)2.93759093
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93733427
100response to host (GO:0075136)2.93733427
101response to host defenses (GO:0052200)2.93733427
102negative regulation of phagocytosis (GO:0050765)2.93700360
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93534356
104regulation of natural killer cell mediated immunity (GO:0002715)2.93534356
105regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91321615
106mast cell activation (GO:0045576)2.91167463
107response to type I interferon (GO:0034340)2.90920724
108regulation of alpha-beta T cell proliferation (GO:0046640)2.90406322
109regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89749936
110regulation of interleukin-2 biosynthetic process (GO:0045076)2.87177075
111response to protozoan (GO:0001562)2.86292123
112modulation by symbiont of host cellular process (GO:0044068)2.86259027
113myeloid dendritic cell activation (GO:0001773)2.85055816
114type I interferon signaling pathway (GO:0060337)2.84790140
115cellular response to type I interferon (GO:0071357)2.84790140
116lymphocyte homeostasis (GO:0002260)2.84556026
117regulation of mast cell degranulation (GO:0043304)2.82387302
118regulation of mast cell activation (GO:0033003)2.81243826
119pinocytosis (GO:0006907)2.80342390
120B cell proliferation (GO:0042100)2.79790349
121modulation by virus of host process (GO:0019054)2.79620057
122negative regulation of B cell proliferation (GO:0030889)2.79134973
123regulation of B cell proliferation (GO:0030888)2.78430160
124cellular response to zinc ion (GO:0071294)2.78181425
125positive regulation of mast cell activation (GO:0033005)2.75579758
126macrophage activation (GO:0042116)2.75255626
127regulation of granulocyte differentiation (GO:0030852)2.74672652
128positive regulation of B cell proliferation (GO:0030890)2.73417960
129T cell receptor signaling pathway (GO:0050852)2.72368830
130positive regulation of interleukin-2 production (GO:0032743)2.72332513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61421365
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37536921
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.00803104
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.81353958
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87739606
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.84768966
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.82026084
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.78158024
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75601337
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.36315465
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07241621
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05945194
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01028332
14RUNX_20019798_ChIP-Seq_JUKART_Human2.87673111
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.87196367
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.85193244
17SCL_19346495_ChIP-Seq_HPC-7_Human2.84636049
18VDR_21846776_ChIP-Seq_THP-1_Human2.69807018
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.66910984
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58092593
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55135098
22MYB_26560356_Chip-Seq_TH2_Human2.44948304
23* SPI1_23547873_ChIP-Seq_NB4_Human2.42826395
24MYC_22102868_ChIP-Seq_BL_Human2.38849088
25MAF_26560356_Chip-Seq_TH1_Human2.25220539
26* SPI1_23127762_ChIP-Seq_K562_Human2.23155932
27VDR_24763502_ChIP-Seq_THP-1_Human2.23055285
28MYB_26560356_Chip-Seq_TH1_Human2.22290100
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18139306
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14572727
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11733720
32* RUNX1_22412390_ChIP-Seq_EML_Mouse2.01317957
33UTX_26944678_Chip-Seq_JUKART_Human1.99822834
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94835970
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92728531
36E2F7_22180533_ChIP-Seq_HELA_Human1.87059894
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84721457
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78799722
39PU_27001747_Chip-Seq_BMDM_Mouse1.73134733
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72025898
41TCF7_22412390_ChIP-Seq_EML_Mouse1.71550612
42LXR_22292898_ChIP-Seq_THP-1_Human1.68816132
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65509987
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63925825
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59497528
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48966775
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.47754362
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47011503
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46972639
50GATA3_27048872_Chip-Seq_THYMUS_Human1.46913587
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44143090
52VDR_24787735_ChIP-Seq_THP-1_Human1.44127072
53MAF_26560356_Chip-Seq_TH2_Human1.41796109
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39800899
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38550511
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38374690
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.36597058
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34037922
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33383154
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31401122
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31162362
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29613652
63KDM2B_26808549_Chip-Seq_DND41_Human1.26835634
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23339482
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23287898
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23032112
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22370876
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22124667
69CIITA_25753668_ChIP-Seq_RAJI_Human1.20249654
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20018732
71BCL6_27268052_Chip-Seq_Bcells_Human1.18443882
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18197520
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16896419
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.16823722
75GATA1_19941826_ChIP-Seq_K562_Human1.16164131
76BCOR_27268052_Chip-Seq_Bcells_Human1.12996822
77NCOR1_26117541_ChIP-Seq_K562_Human1.08820507
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07754132
79GATA3_26560356_Chip-Seq_TH2_Human1.07353436
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.06751644
81* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03596750
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00887973
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99775993
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99570086
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98938647
86SA1_27219007_Chip-Seq_ERYTHROID_Human0.98169086
87RACK7_27058665_Chip-Seq_MCF-7_Human0.97945268
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.94516737
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94411696
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92231822
91KDM2B_26808549_Chip-Seq_K562_Human0.90360724
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88215580
93GATA1_22025678_ChIP-Seq_K562_Human0.87001436
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86811734
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86466672
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86147824
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84915357
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84682816
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83106456
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.83082088
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82749207
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81910515
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81665398
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79056551
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.78674120
106GATA2_19941826_ChIP-Seq_K562_Human0.73682774
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68074996
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67218069
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.67209789
110SMRT_27268052_Chip-Seq_Bcells_Human0.63850393
111* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.62463673
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61623582
113STAT1_20625510_ChIP-Seq_HELA_Human0.61192338
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.59836759
115FOXM1_23109430_ChIP-Seq_U2OS_Human0.59210124
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58734299
117ETS1_22383799_ChIP-Seq_G1ME_Mouse0.57705951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.49091560
2MP0001790_abnormal_immune_system3.40090069
3MP0005387_immune_system_phenotype3.40090069
4MP0001800_abnormal_humoral_immune3.30299606
5MP0005671_abnormal_response_to3.22825515
6MP0000569_abnormal_digit_pigmentation3.13767298
7MP0003303_peritoneal_inflammation3.09483823
8MP0003436_decreased_susceptibility_to2.99553803
9MP0005000_abnormal_immune_tolerance2.98469535
10MP0002452_abnormal_antigen_presenting2.96326315
11MP0000685_abnormal_immune_system2.95129842
12MP0002419_abnormal_innate_immunity2.83869677
13MP0002723_abnormal_immune_serum2.76108874
14MP0002420_abnormal_adaptive_immunity2.70416266
15MP0001819_abnormal_immune_cell2.67987339
16MP0009785_altered_susceptibility_to2.60312769
17MP0005025_abnormal_response_to2.58033744
18MP0003763_abnormal_thymus_physiology2.57973289
19MP0003183_abnormal_peptide_metabolism2.54792836
20MP0002148_abnormal_hypersensitivity_rea2.47553770
21MP0005174_abnormal_tail_pigmentation2.37397275
22MP0002398_abnormal_bone_marrow2.28711266
23MP0002396_abnormal_hematopoietic_system2.28147536
24MP0005464_abnormal_platelet_physiology2.25640405
25MP0000716_abnormal_immune_system2.16647882
26MP0002405_respiratory_system_inflammati2.15554089
27MP0004510_myositis2.15495273
28MP0006082_CNS_inflammation2.11389970
29MP0003172_abnormal_lysosome_physiology2.07402255
30MP0002166_altered_tumor_susceptibility2.06929834
31MP0005058_abnormal_lysosome_morphology1.97351114
32MP0003300_gastrointestinal_ulcer1.94921472
33MP0000015_abnormal_ear_pigmentation1.93504743
34MP0000689_abnormal_spleen_morphology1.92901988
35MP0001873_stomach_inflammation1.85038068
36MP0002006_tumorigenesis1.80689324
37MP0002722_abnormal_immune_system1.80617472
38MP0002429_abnormal_blood_cell1.72287183
39MP0005451_abnormal_body_composition1.71475183
40MP0009278_abnormal_bone_marrow1.70709225
41MP0001845_abnormal_inflammatory_respons1.67961488
42MP0010155_abnormal_intestine_physiology1.67398389
43MP0009333_abnormal_splenocyte_physiolog1.66710346
44MP0003724_increased_susceptibility_to1.60578976
45MP0000465_gastrointestinal_hemorrhage1.60101256
46MP0004808_abnormal_hematopoietic_stem1.57459391
47MP0000703_abnormal_thymus_morphology1.56977838
48MP0004947_skin_inflammation1.52886214
49MP0001853_heart_inflammation1.52655356
50MP0005310_abnormal_salivary_gland1.48726125
51MP0001533_abnormal_skeleton_physiology1.45374683
52MP0003787_abnormal_imprinting1.41108224
53MP0002933_joint_inflammation1.37028761
54MP0003866_abnormal_defecation1.34337366
55MP0003075_altered_response_to1.22616637
56MP0008469_abnormal_protein_level1.18432861
57MP0004883_abnormal_blood_vessel1.17460160
58MP0005397_hematopoietic_system_phenotyp1.16669948
59MP0001545_abnormal_hematopoietic_system1.16669948
60MP0002998_abnormal_bone_remodeling1.15674942
61MP0001851_eye_inflammation1.14400494
62MP0003448_altered_tumor_morphology1.14309982
63MP0003045_fibrosis1.13233448
64MP0000490_abnormal_crypts_of1.12143361
65MP0002095_abnormal_skin_pigmentation1.09126816
66MP0005075_abnormal_melanosome_morpholog1.07946348
67MP0002277_abnormal_respiratory_mucosa1.05954885
68MP0000858_altered_metastatic_potential1.03736138
69MP0004381_abnormal_hair_follicle1.02426745
70MP0005409_darkened_coat_color0.98350972
71MP0009840_abnormal_foam_cell0.96929214
72MP0000604_amyloidosis0.95967363
73MP0009764_decreased_sensitivity_to0.90486041
74MP0002138_abnormal_hepatobiliary_system0.89793316
75MP0001986_abnormal_taste_sensitivity0.89124406
76MP0000371_diluted_coat_color0.89103952
77MP0005164_abnormal_response_to0.88372686
78MP0008004_abnormal_stomach_pH0.88008411
79MP0002928_abnormal_bile_duct0.85501973
80MP0003191_abnormal_cellular_cholesterol0.84389597
81MP0010307_abnormal_tumor_latency0.84383395
82MP0005076_abnormal_cell_differentiation0.78816716
83MP0008057_abnormal_DNA_replication0.77748731
84MP0003656_abnormal_erythrocyte_physiolo0.73908080
85MP0009765_abnormal_xenobiotic_induced0.70676525
86MP0005257_abnormal_intraocular_pressure0.70044030
87MP0008058_abnormal_DNA_repair0.67763338
88MP0002019_abnormal_tumor_incidence0.66936638
89MP0000343_altered_response_to0.65626592
90MP0005390_skeleton_phenotype0.65517190
91MP0003828_pulmonary_edema0.65350405
92MP0009763_increased_sensitivity_to0.65041742
93MP0008874_decreased_physiological_sensi0.64740686
94MP0008260_abnormal_autophagy0.63526997
95MP0003453_abnormal_keratinocyte_physiol0.63344030
96MP0003091_abnormal_cell_migration0.63216981
97MP0008961_abnormal_basal_metabolism0.59083787
98MP0003795_abnormal_bone_structure0.58391523
99MP0001663_abnormal_digestive_system0.57482184
100MP0003221_abnormal_cardiomyocyte_apopto0.56268459
101MP0000249_abnormal_blood_vessel0.55229008
102MP0003806_abnormal_nucleotide_metabolis0.54075804
103MP0005381_digestive/alimentary_phenotyp0.54033388
104MP0005670_abnormal_white_adipose0.53834092
105MP0003690_abnormal_glial_cell0.53428775
106MP0003566_abnormal_cell_adhesion0.53108094
107MP0002132_abnormal_respiratory_system0.52820644
108MP0002075_abnormal_coat/hair_pigmentati0.50944519
109MP0002136_abnormal_kidney_physiology0.50746808
110MP0002009_preneoplasia0.48564270
111MP0001186_pigmentation_phenotype0.48193818
112MP0002254_reproductive_system_inflammat0.47981642
113MP0005319_abnormal_enzyme/_coenzyme0.46831739
114MP0002332_abnormal_exercise_endurance0.46816721
115MP0005166_decreased_susceptibility_to0.46551650
116MP0002693_abnormal_pancreas_physiology0.46416136
117MP0000609_abnormal_liver_physiology0.46154615
118MP0005621_abnormal_cell_physiology0.44977725
119MP0000767_abnormal_smooth_muscle0.42868333

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.77674039
2Eczematoid dermatitis (HP:0000976)5.27035186
3Recurrent bacterial skin infections (HP:0005406)5.18977561
4Recurrent fungal infections (HP:0002841)4.53953403
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.26392674
6Recurrent cutaneous fungal infections (HP:0011370)4.25077294
7Chronic mucocutaneous candidiasis (HP:0002728)4.25077294
8Recurrent viral infections (HP:0004429)4.15340852
9Agammaglobulinemia (HP:0004432)4.07669053
10Recurrent skin infections (HP:0001581)3.90200891
11Panhypogammaglobulinemia (HP:0003139)3.81146419
12Gastrointestinal infarctions (HP:0005244)3.79511584
13Obstructive lung disease (HP:0006536)3.71265751
14Chronic obstructive pulmonary disease (HP:0006510)3.71265751
15Meningitis (HP:0001287)3.64207459
16Mediastinal lymphadenopathy (HP:0100721)3.58455801
17Abnormality of the fingertips (HP:0001211)3.55357241
18Inflammation of the large intestine (HP:0002037)3.47760922
19Chronic otitis media (HP:0000389)3.45378514
20IgM deficiency (HP:0002850)3.44675252
21Recurrent gram-negative bacterial infections (HP:0005420)3.41723620
22Keratoconjunctivitis sicca (HP:0001097)3.30550894
23Gingivitis (HP:0000230)3.29980253
24Elevated erythrocyte sedimentation rate (HP:0003565)3.29731820
25Cellulitis (HP:0100658)3.27259671
26Stomatitis (HP:0010280)3.25380402
27Urticaria (HP:0001025)3.24596074
28Gastrointestinal inflammation (HP:0004386)3.23240535
29Myositis (HP:0100614)3.22425999
30Colitis (HP:0002583)3.22156059
31Vasculitis (HP:0002633)3.21627798
32Recurrent bronchitis (HP:0002837)3.12399835
33Keratoconjunctivitis (HP:0001096)3.02153699
34Thyroiditis (HP:0100646)2.96927811
35Abnormality of macrophages (HP:0004311)2.95126029
36Chronic diarrhea (HP:0002028)2.93427453
37T lymphocytopenia (HP:0005403)2.93308553
38Autoimmune thrombocytopenia (HP:0001973)2.88960426
39Abnormality of T cell number (HP:0011839)2.88744768
40Eosinophilia (HP:0001880)2.83896777
41Lymphopenia (HP:0001888)2.81311507
42Hypochromic microcytic anemia (HP:0004840)2.72391339
43Gastrointestinal stroma tumor (HP:0100723)2.70622335
44Spontaneous hematomas (HP:0007420)2.70620516
45Hypochromic anemia (HP:0001931)2.70319197
46Retrobulbar optic neuritis (HP:0100654)2.70052909
47Optic neuritis (HP:0100653)2.70052909
48Vacuolated lymphocytes (HP:0001922)2.69880881
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.68721780
50Osteomyelitis (HP:0002754)2.66893548
51Pustule (HP:0200039)2.65375492
52Leukocytosis (HP:0001974)2.65092321
53Abnormality of T cells (HP:0002843)2.64477745
54Systemic lupus erythematosus (HP:0002725)2.63533202
55Periodontitis (HP:0000704)2.62986193
56Episodic fever (HP:0001954)2.59285113
57Recurrent pneumonia (HP:0006532)2.59043815
58Prolonged bleeding time (HP:0003010)2.58748770
59Severe combined immunodeficiency (HP:0004430)2.57335891
60Petechiae (HP:0000967)2.56440542
61Recurrent sinusitis (HP:0011108)2.54227801
62Abnormality of B cell number (HP:0010975)2.54186922
63B lymphocytopenia (HP:0010976)2.54186922
64Increased IgM level (HP:0003496)2.53369497
65Orchitis (HP:0100796)2.51611103
66Abnormality of eosinophils (HP:0001879)2.47690954
67Granulocytopenia (HP:0001913)2.47348884
68Cheilitis (HP:0100825)2.44914414
69Pulmonary embolism (HP:0002204)2.44829960
70Pulmonary infiltrates (HP:0002113)2.44376968
71Abnormality of T cell physiology (HP:0011840)2.42405399
72Abnormality of liposaccharide metabolism (HP:0010968)2.41504227
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.41504227
74Abnormality of glycolipid metabolism (HP:0010969)2.41504227
75Anorexia (HP:0002039)2.39326137
76Increased IgE level (HP:0003212)2.37357736
77Amyloidosis (HP:0011034)2.36822710
78Loss of speech (HP:0002371)2.33901777
79Chronic sinusitis (HP:0011109)2.33736040
80Recurrent lower respiratory tract infections (HP:0002783)2.33323849
81Encephalitis (HP:0002383)2.28816952
82Hypergammaglobulinemia (HP:0010702)2.27493065
83Purpura (HP:0000979)2.25599694
84Glomerulonephritis (HP:0000099)2.25004406
85Sepsis (HP:0100806)2.18767065
86Combined immunodeficiency (HP:0005387)2.18541447
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18208346
88Peritonitis (HP:0002586)2.18201664
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17666647
90Emphysema (HP:0002097)2.17123585
91Abnormality of the pleura (HP:0002103)2.16751435
92Hepatosplenomegaly (HP:0001433)2.15653163
93IgA deficiency (HP:0002720)2.15415024
94IgG deficiency (HP:0004315)2.13381179
95Thoracic kyphosis (HP:0002942)2.12293398
96Dysostosis multiplex (HP:0000943)2.12098409
97Premature loss of primary teeth (HP:0006323)2.11458629
98Hemoptysis (HP:0002105)2.11382976
99Gangrene (HP:0100758)2.11131788
100Chromsome breakage (HP:0040012)2.10939555
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.10675457
102Increased serum ferritin (HP:0003281)2.09574870
103Gingival bleeding (HP:0000225)2.06842445
104Microcytic anemia (HP:0001935)2.06401814
105Nasal polyposis (HP:0100582)2.05460156
106Slow saccadic eye movements (HP:0000514)2.04653194
107Viral hepatitis (HP:0006562)2.03811859
108Epistaxis (HP:0000421)2.02878219
109Abnormality of the peritoneum (HP:0002585)2.02425018
110Restrictive lung disease (HP:0002091)2.01517020
111Papilloma (HP:0012740)2.00956863
112Verrucae (HP:0200043)2.00956863
113Glomerulopathy (HP:0100820)1.99932992
114Prostate neoplasm (HP:0100787)1.96154491
115Disinhibition (HP:0000734)1.94005247
116Leukopenia (HP:0001882)1.93502896
117Lymphoma (HP:0002665)1.92342292
118Metaphyseal cupping (HP:0003021)1.91658719
119Abnormality of the endocardium (HP:0004306)1.91629798
120Arterial thrombosis (HP:0004420)1.89968078
121Autoimmune hemolytic anemia (HP:0001890)1.89219232
122Chest pain (HP:0100749)1.88907506
123Abnormality of the prostate (HP:0008775)1.88668376
124Homocystinuria (HP:0002156)1.88201137
125Abnormality of homocysteine metabolism (HP:0010919)1.88201137
126Increased cerebral lipofuscin (HP:0011813)1.88150604
127Hematochezia (HP:0002573)1.87221745
128Skin ulcer (HP:0200042)1.86557182
129Absent frontal sinuses (HP:0002688)1.86399186
130Abnormality of the thoracic spine (HP:0100711)1.85447807
131Basal ganglia calcification (HP:0002135)1.84271425
132Abnormality of DNA repair (HP:0003254)1.83548584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.60595319
2IRAK43.71002148
3IRAK33.03086882
4TXK3.02214446
5BLK2.96854588
6TYK22.95128338
7MAP3K142.94822774
8PRPF4B2.87772124
9JAK32.24907043
10SIK22.20317689
11RIPK42.20171134
12IKBKE2.14651507
13JAK12.09974427
14KIT2.00675066
15ZAP701.94796833
16BTK1.93131218
17CSF1R1.81436490
18HCK1.80518592
19TBK11.76917357
20TEC1.75789927
21TAOK11.75402795
22FES1.73686698
23MAP3K131.70162878
24STK101.70033143
25SYK1.70020593
26MAP3K111.68031502
27ITK1.64005297
28TGFBR21.63191579
29IKBKB1.62899664
30MAP3K31.61507812
31CLK11.56144732
32CSK1.54026064
33LCK1.50996993
34CAMK1G1.48990843
35TAOK31.48274874
36CAMK1D1.46843593
37TRIB31.45620890
38CDK121.40266374
39GRK61.30723171
40EPHB11.30363766
41LYN1.25457065
42MAP3K11.21358520
43CHUK1.19849239
44MAP3K101.16664914
45SMG11.13559270
46TAOK21.11685064
47MARK31.09889761
48MATK1.07106265
49TNIK1.05801175
50ERN11.03816489
51FGFR41.03783194
52KSR21.02065356
53TESK21.01604312
54TNK21.00466985
55FGFR30.98820327
56SIK30.98101222
57SIK10.95175206
58PIM10.87536529
59BRD40.85428255
60NLK0.84570685
61IRAK20.84256035
62PDK10.83589344
63MAP2K30.81223857
64YES10.80986585
65MAP3K60.80306200
66INSRR0.75875467
67EEF2K0.75238879
68PRKCQ0.74667137
69TRPM70.73060921
70EIF2AK20.71844568
71PDPK10.71794132
72BMPR20.71415536
73RPS6KA40.71096132
74IRAK10.69251417
75SGK30.69242934
76FGR0.67409497
77JAK20.65898223
78NUAK10.63634535
79CDK190.60734395
80HIPK20.60277429
81STK40.60180457
82MARK20.59294550
83PRKD20.56230385
84GRK70.54081111
85ZAK0.52031974
86DYRK1B0.51088883
87CAMKK10.50775923
88RPS6KC10.50650338
89RPS6KL10.50650338
90CDK90.49421752
91PTK60.48863001
92NEK90.48718346
93SGK20.48382792
94RET0.48367102
95ABL10.48244981
96PRKCH0.47174997
97MAP3K50.46063174
98PKN10.45183390
99EPHA30.40438570
100PIK3CG0.40349426
101MAPK70.40190516
102FYN0.39791414
103MAP3K70.39565350
104MAPK120.39390153
105STK110.37396365
106RPS6KA60.36023420
107PRKAA20.35938793
108MAPKAPK20.34883891
109ATR0.34812632
110LRRK20.34708249
111CAMK40.33446246
112PKN20.33044804
113TTN0.32907473
114DMPK0.32401955
115EGFR0.32167803
116MAP2K40.31892698
117PTK2B0.31560145
118CDK40.31508962
119MAP3K80.31420728
120CDK60.31305916
121INSR0.30535110
122MAPK40.30437613
123RPS6KA20.30080114
124CAMKK20.30004211
125MKNK20.29900872
126CDC42BPA0.29759160
127MAP2K60.29688749
128ICK0.28063455
129IGF1R0.27970395
130PDGFRB0.27913464
131GRK10.27863882
132MOS0.27352968

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.31021113
2B cell receptor signaling pathway_Homo sapiens_hsa046622.72688978
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.68787105
4Leishmaniasis_Homo sapiens_hsa051402.54901017
5Osteoclast differentiation_Homo sapiens_hsa043802.46580799
6Measles_Homo sapiens_hsa051622.20391171
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08136566
8Hematopoietic cell lineage_Homo sapiens_hsa046402.06894949
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.04183892
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98829615
11Other glycan degradation_Homo sapiens_hsa005111.96911431
12Staphylococcus aureus infection_Homo sapiens_hsa051501.94897445
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93828104
14T cell receptor signaling pathway_Homo sapiens_hsa046601.87096712
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80633785
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68093154
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66065058
18Chemokine signaling pathway_Homo sapiens_hsa040621.57447881
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.55329475
20Tuberculosis_Homo sapiens_hsa051521.53939586
21Antigen processing and presentation_Homo sapiens_hsa046121.53078241
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.52151313
23Graft-versus-host disease_Homo sapiens_hsa053321.51093324
24Herpes simplex infection_Homo sapiens_hsa051681.49292138
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47880319
26Influenza A_Homo sapiens_hsa051641.47205865
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45668620
28Allograft rejection_Homo sapiens_hsa053301.44786030
29Pertussis_Homo sapiens_hsa051331.40796307
30Toxoplasmosis_Homo sapiens_hsa051451.40035898
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37276985
32TNF signaling pathway_Homo sapiens_hsa046681.28840015
33Malaria_Homo sapiens_hsa051441.28775621
34Acute myeloid leukemia_Homo sapiens_hsa052211.19422500
35Hepatitis B_Homo sapiens_hsa051611.18059520
36Lysosome_Homo sapiens_hsa041421.17392124
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.16683336
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15994191
39Apoptosis_Homo sapiens_hsa042101.15456301
40Asthma_Homo sapiens_hsa053101.13081849
41Chronic myeloid leukemia_Homo sapiens_hsa052201.08151945
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05045823
43Shigellosis_Homo sapiens_hsa051311.03898231
44Pancreatic cancer_Homo sapiens_hsa052121.03255552
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01947516
46Viral myocarditis_Homo sapiens_hsa054161.01840545
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96911560
48Autoimmune thyroid disease_Homo sapiens_hsa053200.96446588
49Platelet activation_Homo sapiens_hsa046110.94188829
50Hepatitis C_Homo sapiens_hsa051600.92964227
51Legionellosis_Homo sapiens_hsa051340.92146346
52Salmonella infection_Homo sapiens_hsa051320.90520092
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86913082
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.85736694
55Rheumatoid arthritis_Homo sapiens_hsa053230.85161928
56Renal cell carcinoma_Homo sapiens_hsa052110.84041422
57Non-homologous end-joining_Homo sapiens_hsa034500.83075556
58Fanconi anemia pathway_Homo sapiens_hsa034600.81483651
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80485327
60Epstein-Barr virus infection_Homo sapiens_hsa051690.79470403
61Lysine degradation_Homo sapiens_hsa003100.70615360
62Notch signaling pathway_Homo sapiens_hsa043300.69692262
63Phagosome_Homo sapiens_hsa041450.69605070
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68742430
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68666665
66HTLV-I infection_Homo sapiens_hsa051660.68386260
67Prolactin signaling pathway_Homo sapiens_hsa049170.68128110
68Endometrial cancer_Homo sapiens_hsa052130.65875807
69Inositol phosphate metabolism_Homo sapiens_hsa005620.65532405
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.63210796
71African trypanosomiasis_Homo sapiens_hsa051430.62128158
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60369235
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59083492
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59017054
75Non-small cell lung cancer_Homo sapiens_hsa052230.57755196
76Amoebiasis_Homo sapiens_hsa051460.57390896
77GnRH signaling pathway_Homo sapiens_hsa049120.57368873
78Type II diabetes mellitus_Homo sapiens_hsa049300.57268113
79Colorectal cancer_Homo sapiens_hsa052100.56594313
80ABC transporters_Homo sapiens_hsa020100.55833572
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55044344
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54913692
83MAPK signaling pathway_Homo sapiens_hsa040100.54413103
84Viral carcinogenesis_Homo sapiens_hsa052030.53241050
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52684218
86mTOR signaling pathway_Homo sapiens_hsa041500.51502052
87Small cell lung cancer_Homo sapiens_hsa052220.50448910
88HIF-1 signaling pathway_Homo sapiens_hsa040660.49717228
89Homologous recombination_Homo sapiens_hsa034400.48444725
90Type I diabetes mellitus_Homo sapiens_hsa049400.48214813
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.47781623
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47433576
93Prostate cancer_Homo sapiens_hsa052150.46153715
94FoxO signaling pathway_Homo sapiens_hsa040680.44972135
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44023711
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43755175
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43432524
98VEGF signaling pathway_Homo sapiens_hsa043700.43385083
99Bladder cancer_Homo sapiens_hsa052190.43134387
100ErbB signaling pathway_Homo sapiens_hsa040120.43028711
101Sphingolipid metabolism_Homo sapiens_hsa006000.42545337
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41798029
103MicroRNAs in cancer_Homo sapiens_hsa052060.41703791
104Dorso-ventral axis formation_Homo sapiens_hsa043200.41295771
105Endocytosis_Homo sapiens_hsa041440.40614963
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.39118755
107Base excision repair_Homo sapiens_hsa034100.38151656
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.36214152
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34102430
110Choline metabolism in cancer_Homo sapiens_hsa052310.33162953
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32599232
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32389577
113Glioma_Homo sapiens_hsa052140.31843175
114Insulin resistance_Homo sapiens_hsa049310.31747508
115Rap1 signaling pathway_Homo sapiens_hsa040150.31440452
116Estrogen signaling pathway_Homo sapiens_hsa049150.31438811
117p53 signaling pathway_Homo sapiens_hsa041150.30473682

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