ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome assembly (GO:0001675)	9.49802107
2	sperm motility (GO:0030317)	9.40956893
3	axonemal dynein complex assembly (GO:0070286)	9.10497574
4	sperm-egg recognition (GO:0035036)	8.99805569
5	male meiosis I (GO:0007141)	8.62998148
6	binding of sperm to zona pellucida (GO:0007339)	8.47964894
7	chromosome organization involved in meiosis (GO:0070192)	8.43918035
8	multicellular organism reproduction (GO:0032504)	8.24344221
9	spermatid development (GO:0007286)	8.07493664
10	cell-cell recognition (GO:0009988)	8.05172023
11	meiotic nuclear division (GO:0007126)	7.98548598
12	plasma membrane fusion (GO:0045026)	7.95675716
13	acrosome reaction (GO:0007340)	7.78099754
14	epithelial cilium movement (GO:0003351)	7.43522345
15	motile cilium assembly (GO:0044458)	7.37206759
16	meiosis I (GO:0007127)	7.13663050
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.95901275
18	cell wall macromolecule catabolic process (GO:0016998)	6.78334230
19	cell wall macromolecule metabolic process (GO:0044036)	6.78334230
20	reproduction (GO:0000003)	6.68717175
21	cilium movement (GO:0003341)	6.61020707
22	regulation of meiosis I (GO:0060631)	6.55778026
23	gene silencing by RNA (GO:0031047)	5.88789380
24	regulation of cilium movement (GO:0003352)	5.78750419
25	meiotic cell cycle (GO:0051321)	5.69322664
26	fertilization (GO:0009566)	5.57404756
27	single fertilization (GO:0007338)	5.57240498
28	spermatogenesis (GO:0007283)	5.41560269
29	male gamete generation (GO:0048232)	5.40064593
30	germ cell development (GO:0007281)	5.25243279
31	negative regulation of inclusion body assembly (GO:0090084)	5.24203701
32	meiotic cell cycle process (GO:1903046)	5.23475058
33	sperm capacitation (GO:0048240)	5.17555775
34	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.07781478
35	gamete generation (GO:0007276)	4.97074867
36	genitalia morphogenesis (GO:0035112)	4.87218783
37	synapsis (GO:0007129)	4.77493411
38	microtubule depolymerization (GO:0007019)	4.49747213
39	ventricular system development (GO:0021591)	4.48549051
40	nuclear pore complex assembly (GO:0051292)	4.18300842
41	DNA alkylation (GO:0006305)	4.17150631
42	DNA methylation (GO:0006306)	4.17150631
43	regulation of inclusion body assembly (GO:0090083)	4.12481052
44	seminiferous tubule development (GO:0072520)	4.11742623
45	monoubiquitinated protein deubiquitination (GO:0035520)	4.03070394
46	gene silencing (GO:0016458)	3.92512421
47	protein localization to cilium (GO:0061512)	3.91113338
48	multicellular organismal reproductive process (GO:0048609)	3.86190415
49	microtubule severing (GO:0051013)	3.74851181
50	cell recognition (GO:0008037)	3.62271034
51	sister chromatid cohesion (GO:0007062)	3.58148846
52	organic cation transport (GO:0015695)	3.54809954
53	nuclear pore organization (GO:0006999)	3.52256864
54	chaperone-mediated protein complex assembly (GO:0051131)	3.50538830
55	sex differentiation (GO:0007548)	3.45902071
56	regulation of microtubule-based movement (GO:0060632)	3.42796473
57	intraciliary transport (GO:0042073)	3.42237862
58	regulation of histone H3-K9 methylation (GO:0051570)	3.39947819
59	regulation of centriole replication (GO:0046599)	3.37313338
60	histone exchange (GO:0043486)	3.29257419
61	calcium ion-dependent exocytosis (GO:0017156)	3.27797179
62	DNA methylation or demethylation (GO:0044728)	3.25711395
63	negative regulation of organelle assembly (GO:1902116)	3.25465289
64	reciprocal meiotic recombination (GO:0007131)	3.24970406
65	reciprocal DNA recombination (GO:0035825)	3.24970406
66	DNA packaging (GO:0006323)	3.23363829
67	protein polyglutamylation (GO:0018095)	3.20156700
68	pore complex assembly (GO:0046931)	3.18865595
69	oogenesis (GO:0048477)	3.18291073
70	translesion synthesis (GO:0019985)	3.11702310
71	resolution of meiotic recombination intermediates (GO:0000712)	3.10195240
72	meiotic chromosome segregation (GO:0045132)	3.06864363
73	multicellular organismal development (GO:0007275)	3.06474525
74	regulation of chromatin binding (GO:0035561)	3.06426252
75	heterochromatin organization (GO:0070828)	3.04866302
76	negative regulation of DNA repair (GO:0045738)	3.01188524
77	left/right pattern formation (GO:0060972)	2.97158411
78	DNA replication-dependent nucleosome assembly (GO:0006335)	2.96641070
79	DNA replication-dependent nucleosome organization (GO:0034723)	2.96641070
80	spermatid nucleus differentiation (GO:0007289)	2.96317426
81	chromosome condensation (GO:0030261)	2.95144930
82	regulation of protein polyubiquitination (GO:1902914)	2.91568617
83	regulation of spindle checkpoint (GO:0090231)	2.79050212
84	carnitine transmembrane transport (GO:1902603)	2.78777215
85	nucleus organization (GO:0006997)	2.77247411
86	amino-acid betaine transport (GO:0015838)	2.73453644
87	carnitine transport (GO:0015879)	2.73453644
88	DNA synthesis involved in DNA repair (GO:0000731)	2.71515522
89	DNA modification (GO:0006304)	2.71430670
90	blastocyst development (GO:0001824)	2.70575783
91	axoneme assembly (GO:0035082)	2.69019031
92	chromosome organization (GO:0051276)	2.67747930
93	positive regulation of meiosis (GO:0045836)	2.66031532
94	piRNA metabolic process (GO:0034587)	15.4777311
95	cilium or flagellum-dependent cell motility (GO:0001539)	12.5173991
96	male meiosis (GO:0007140)	12.0145934
97	synaptonemal complex organization (GO:0070193)	11.9521116
98	synaptonemal complex assembly (GO:0007130)	11.8528860
99	fusion of sperm to egg plasma membrane (GO:0007342)	10.6181215
100	DNA methylation involved in gamete generation (GO:0043046)	10.5148889

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.03929872
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.70410679
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.49907134
4	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.87099408
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.79349028
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	13.2421370
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.96071515
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91022272
9	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.90551003
10	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.89817669
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75136809
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74958261
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.72973009
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.59644399
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.58376273
16	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58151915
17	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.49360621
18	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.48188751
19	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47749074
20	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46521556
21	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.42150961
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.34738995
23	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34381083
24	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.33643002
25	STAT1_17558387_ChIP-Seq_HELA_Human	1.31888793
26	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29876266
27	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28931321
28	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.25724875
29	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.24722270
30	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.23597914
31	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.21227548
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19557036
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19028803
34	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.15660274
35	AR_21909140_ChIP-Seq_LNCAP_Human	1.15650512
36	VDR_22108803_ChIP-Seq_LS180_Human	1.12094370
37	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.11967263
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11812695
39	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.10532957
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10231847
41	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09441851
42	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.08209963
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.08100967
44	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.06935251
45	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.04549589
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03874253
47	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.03257275
48	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.03034853
49	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01482366
50	P53_21459846_ChIP-Seq_SAOS-2_Human	1.01178212
51	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.99573759
52	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97595690
53	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97392318
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96144956
55	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95652853
56	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.95015168
57	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.94364955
58	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94273554
59	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93440208
60	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.92471266
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91741465
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91741465
63	CBP_20019798_ChIP-Seq_JUKART_Human	0.91637152
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91637152
65	SOX2_21211035_ChIP-Seq_LN229_Human	0.91371837
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89137897
67	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.88489709
68	E2F7_22180533_ChIP-Seq_HELA_Human	0.88172774
69	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.88042125
70	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.88015935
71	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.87631021
72	ERG_20517297_ChIP-Seq_VCAP_Human	0.86626542
73	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.86501314
74	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.85973937
75	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.85474376
76	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.85406096
77	PHF8_20622854_ChIP-Seq_HELA_Human	0.85264054
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85106300
79	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.84683611
80	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.84233421
81	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.83990470
82	GATA3_26560356_Chip-Seq_TH1_Human	0.83775992
83	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.82707980
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.81709393
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.81101210
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.81047458
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80448956
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.80210525
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.80127507
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.79387833
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.78794447
92	P300_18555785_Chip-Seq_ESCs_Mouse	0.78704294
93	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.78163720
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.78071934
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.78071934
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.76095279
97	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.76051069
98	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.74927560
99	KDM2B_26808549_Chip-Seq_REH_Human	0.73227893
100	GF1_26923725_Chip-Seq_HPCs_Mouse	0.72681466

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.31526253
2	MP0001929_abnormal_gametogenesis	5.57927611
3	MP0003698_abnormal_male_reproductive	5.49429010
4	MP0002210_abnormal_sex_determination	4.65872152
5	MP0008057_abnormal_DNA_replication	4.03713790
6	MP0001145_abnormal_male_reproductive	3.92598993
7	MP0000653_abnormal_sex_gland	3.41712934
8	MP0002161_abnormal_fertility/fecundity	2.97989787
9	MP0008995_early_reproductive_senescence	2.90481700
10	MP0002653_abnormal_ependyma_morphology	2.70405801
11	MP0010094_abnormal_chromosome_stability	2.69098262
12	MP0003786_premature_aging	2.51399819
13	MP0008058_abnormal_DNA_repair	2.44715925
14	MP0002160_abnormal_reproductive_system	2.13536355
15	MP0005410_abnormal_fertilization	11.3642553
16	MP0005623_abnormal_meninges_morphology	1.80441802
17	MP0008007_abnormal_cellular_replicative	1.68357730
18	MP0003111_abnormal_nucleus_morphology	1.38185231
19	MP0004808_abnormal_hematopoietic_stem	1.26851853
20	MP0005647_abnormal_sex_gland	1.19221237
21	MP0005377_hearing/vestibular/ear_phenot	1.17812579
22	MP0003878_abnormal_ear_physiology	1.17812579
23	MP0010307_abnormal_tumor_latency	1.15240398
24	MP0003077_abnormal_cell_cycle	1.13228947
25	MP0003646_muscle_fatigue	1.10040371
26	MP0003011_delayed_dark_adaptation	1.09451383
27	MP0005389_reproductive_system_phenotype	1.08819509
28	MP0000427_abnormal_hair_cycle	0.99954846
29	MP0009046_muscle_twitch	0.97836977
30	MP0001119_abnormal_female_reproductive	0.91263611
31	MP0001730_embryonic_growth_arrest	0.91196618
32	MP0004957_abnormal_blastocyst_morpholog	0.91018915
33	MP0000358_abnormal_cell_content/	0.84230196
34	MP0002282_abnormal_trachea_morphology	0.83985109
35	MP0003693_abnormal_embryo_hatching	0.83499006
36	MP0003699_abnormal_female_reproductive	0.82280253
37	MP0004134_abnormal_chest_morphology	0.76781223
38	MP0005397_hematopoietic_system_phenotyp	0.72459200
39	MP0001545_abnormal_hematopoietic_system	0.72459200
40	MP0000313_abnormal_cell_death	0.70405063
41	MP0003890_abnormal_embryonic-extraembry	0.70390756
42	MP0005670_abnormal_white_adipose	0.66491357
43	MP0004233_abnormal_muscle_weight	0.63048978
44	MP0001727_abnormal_embryo_implantation	0.62829975
45	MP0005380_embryogenesis_phenotype	0.54543490
46	MP0001672_abnormal_embryogenesis/_devel	0.54543490
47	MP0001697_abnormal_embryo_size	0.54184677
48	MP0001293_anophthalmia	0.52706797
49	MP0001765_abnormal_ion_homeostasis	0.50171046
50	MP0003984_embryonic_growth_retardation	0.50041149
51	MP0000350_abnormal_cell_proliferation	0.47707158
52	MP0000647_abnormal_sebaceous_gland	0.47128433
53	MP0003936_abnormal_reproductive_system	0.47101799
54	MP0008932_abnormal_embryonic_tissue	0.46961520
55	MP0006036_abnormal_mitochondrial_physio	0.46364514
56	MP0002084_abnormal_developmental_patter	0.45986733
57	MP0005174_abnormal_tail_pigmentation	0.45827906
58	MP0002088_abnormal_embryonic_growth/wei	0.45329624
59	MP0003115_abnormal_respiratory_system	0.45110949
60	MP0002269_muscular_atrophy	0.44910927
61	MP0004197_abnormal_fetal_growth/weight/	0.44716804
62	MP0001661_extended_life_span	0.43946808
63	MP0003123_paternal_imprinting	0.43479531
64	MP0002080_prenatal_lethality	0.42035898
65	MP0003045_fibrosis	0.40448867
66	MP0005360_urolithiasis	0.39621863
67	MP0002019_abnormal_tumor_incidence	0.39546736
68	MP0003950_abnormal_plasma_membrane	0.38154120
69	MP0001984_abnormal_olfaction	0.37456349
70	MP0002085_abnormal_embryonic_tissue	0.36797690
71	MP0000015_abnormal_ear_pigmentation	0.36333944
72	MP0002092_abnormal_eye_morphology	0.36066595
73	MP0000569_abnormal_digit_pigmentation	0.34923044
74	MP0005409_darkened_coat_color	0.33582071
75	MP0002971_abnormal_brown_adipose	0.33334375
76	MP0005266_abnormal_metabolism	0.33228963
77	MP0009278_abnormal_bone_marrow	0.32226911
78	MP0002102_abnormal_ear_morphology	0.32025454
79	MP0005636_abnormal_mineral_homeostasis	0.31552534
80	MP0006035_abnormal_mitochondrial_morpho	0.30931770
81	MP0009115_abnormal_fat_cell	0.30683960
82	MP0002086_abnormal_extraembryonic_tissu	0.30638304
83	MP0005391_vision/eye_phenotype	0.30471401
84	MP0005076_abnormal_cell_differentiation	0.30294877
85	MP0004019_abnormal_vitamin_homeostasis	0.29408895
86	MP0002970_abnormal_white_adipose	0.29088081
87	MP0004043_abnormal_pH_regulation	0.28214206
88	MP0006054_spinal_hemorrhage	0.27665519
89	MP0000537_abnormal_urethra_morphology	0.26908783
90	MP0005666_abnormal_adipose_tissue	0.25054750
91	MP0002139_abnormal_hepatobiliary_system	0.23941578
92	MP0009672_abnormal_birth_weight	0.23220686
93	MP0009703_decreased_birth_body	0.23057300
94	MP0003879_abnormal_hair_cell	0.22607394
95	MP0001764_abnormal_homeostasis	0.21880783
96	MP0003861_abnormal_nervous_system	0.21774914
97	MP0004264_abnormal_extraembryonic_tissu	0.21328559
98	MP0008875_abnormal_xenobiotic_pharmacok	0.20766472
99	MP0004036_abnormal_muscle_relaxation	0.19600391
100	MP0001216_abnormal_epidermal_layer	0.19433979

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	8.58064408
2	Abnormal respiratory epithelium morphology (HP:0012253)	7.61773324
3	Abnormal respiratory motile cilium morphology (HP:0005938)	7.61773324
4	Rhinitis (HP:0012384)	7.47693669
5	Abnormal ciliary motility (HP:0012262)	6.85980119
6	Chronic bronchitis (HP:0004469)	6.54963216
7	Nasal polyposis (HP:0100582)	6.13709264
8	Infertility (HP:0000789)	5.61239893
9	Abnormality of the lower motor neuron (HP:0002366)	5.19523176
10	Abnormality of the nasal mucosa (HP:0000433)	5.00069578
11	Abnormal spermatogenesis (HP:0008669)	4.60758359
12	Azoospermia (HP:0000027)	4.58574893
13	Nephronophthisis (HP:0000090)	4.57420014
14	Gonadotropin excess (HP:0000837)	4.37044323
15	Bronchiectasis (HP:0002110)	4.21525326
16	Bronchitis (HP:0012387)	4.09707143
17	Amyotrophic lateral sclerosis (HP:0007354)	3.79140012
18	Fibular hypoplasia (HP:0003038)	3.72299465
19	11 pairs of ribs (HP:0000878)	3.68781388
20	Male infertility (HP:0003251)	3.42321229
21	Abnormality of the renal medulla (HP:0100957)	3.39770411
22	Upper motor neuron abnormality (HP:0002127)	3.23783779
23	Recurrent otitis media (HP:0000403)	3.05292435
24	Recurrent sinusitis (HP:0011108)	2.99755588
25	Tubular atrophy (HP:0000092)	2.91927872
26	Abnormality of the anterior horn cell (HP:0006802)	2.83118300
27	Degeneration of anterior horn cells (HP:0002398)	2.83118300
28	Tubulointerstitial nephritis (HP:0001970)	2.62052391
29	Molar tooth sign on MRI (HP:0002419)	2.61911908
30	Abnormality of midbrain morphology (HP:0002418)	2.61911908
31	Impaired proprioception (HP:0010831)	2.52725663
32	Selective tooth agenesis (HP:0001592)	2.49524001
33	Recurrent bronchitis (HP:0002837)	2.46203095
34	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.44637319
35	Tubulointerstitial abnormality (HP:0001969)	2.42695339
36	Renovascular hypertension (HP:0100817)	2.33977290
37	Spontaneous abortion (HP:0005268)	2.33673268
38	Large eyes (HP:0001090)	2.30978214
39	Postaxial foot polydactyly (HP:0001830)	2.29599914
40	Medial flaring of the eyebrow (HP:0010747)	2.22576004
41	Chronic sinusitis (HP:0011109)	2.22324438
42	Facial cleft (HP:0002006)	2.15425086
43	Impulsivity (HP:0100710)	2.15333015
44	Stage 5 chronic kidney disease (HP:0003774)	2.14419337
45	Microglossia (HP:0000171)	2.13638282
46	Tubulointerstitial fibrosis (HP:0005576)	2.06649975
47	Oculomotor apraxia (HP:0000657)	2.02232927
48	Missing ribs (HP:0000921)	2.01990826
49	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.00678167
50	Short ribs (HP:0000773)	2.00525769
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.4802806
52	Absent/shortened dynein arms (HP:0200106)	10.7984433
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.7984433
54	Sensory axonal neuropathy (HP:0003390)	1.98213872
55	Median cleft lip (HP:0000161)	1.93930533
56	Abnormal gallbladder physiology (HP:0012438)	1.90519414
57	Cholecystitis (HP:0001082)	1.90519414
58	Hyperacusis (HP:0010780)	1.88098545
59	Abnormality of the renal cortex (HP:0011035)	1.86999633
60	Congenital hepatic fibrosis (HP:0002612)	1.85398478
61	Supernumerary spleens (HP:0009799)	1.84984216
62	Breast carcinoma (HP:0003002)	1.84572758
63	Renal dysplasia (HP:0000110)	1.82026978
64	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.79468420
65	Elfin facies (HP:0004428)	1.79411571
66	Hyporeflexia of lower limbs (HP:0002600)	1.78074143
67	Overriding aorta (HP:0002623)	1.76709339
68	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.76424769
69	Conjunctival telangiectasia (HP:0000524)	1.74840796
70	Polydipsia (HP:0001959)	1.66369012
71	Abnormal drinking behavior (HP:0030082)	1.66369012
72	Heterotopia (HP:0002282)	1.64010460
73	Absent frontal sinuses (HP:0002688)	1.63615994
74	J-shaped sella turcica (HP:0002680)	1.60478625
75	Toxemia of pregnancy (HP:0100603)	1.58380145
76	Short thorax (HP:0010306)	1.57472937
77	Spastic tetraparesis (HP:0001285)	1.57449716
78	Insomnia (HP:0100785)	1.52848148
79	Postaxial hand polydactyly (HP:0001162)	1.52373829
80	Abnormality of dentin (HP:0010299)	1.52169854
81	Renal duplication (HP:0000075)	1.50889773
82	Tongue fasciculations (HP:0001308)	1.49486899
83	Abnormality of ocular smooth pursuit (HP:0000617)	1.47428521
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.46001973
85	Abnormal finger flexion creases (HP:0006143)	1.42874910
86	Pachygyria (HP:0001302)	1.41498505
87	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.40873532
88	Flat cornea (HP:0007720)	1.38883975
89	Bile duct proliferation (HP:0001408)	1.36618543
90	Abnormal biliary tract physiology (HP:0012439)	1.36618543
91	Abnormality of permanent molar morphology (HP:0011071)	1.36165789
92	Abnormality of the dental root (HP:0006486)	1.36165789
93	Taurodontia (HP:0000679)	1.36165789
94	Abnormality of the carotid arteries (HP:0005344)	1.34772727
95	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.34733837
96	Absent epiphyses (HP:0010577)	1.34733837
97	Ridged nail (HP:0001807)	1.34518018
98	Abnormality of molar morphology (HP:0011070)	1.34325692
99	Abnormality of molar (HP:0011077)	1.34325692
100	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.34285462

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	9.33028840
2	PDK4	9.33028840
3	PDK2	6.01243385
4	TESK1	3.63577291
5	ICK	2.50057139
6	PRKD3	2.49714609
7	PTK2B	2.26584757
8	NEK2	2.13244788
9	CDC7	2.06996341
10	WNK4	1.96495228
11	STK39	1.80275347
12	PNCK	1.63005988
13	WEE1	1.61684022
14	ACVR1B	1.22615363
15	STK3	1.22409368
16	CDK12	1.04723453
17	WNK1	1.02082290
18	TYRO3	1.01117662
19	STK38	0.97946375
20	ATR	0.95023313
21	CCNB1	0.93349747
22	TTK	0.91438252
23	MAPK15	0.89635790
24	CHEK1	0.87634170
25	DYRK3	0.75685252
26	MST1R	0.75487039
27	PASK	0.71903493
28	PDK1	0.69803319
29	BRSK2	0.69192968
30	PLK1	0.63657806
31	CHEK2	0.63136965
32	DYRK1B	0.60899216
33	BMPR1B	0.58820174
34	ATM	0.53507863
35	PLK4	0.53200627
36	STK38L	0.47531140
37	LMTK2	0.45028010
38	WNK3	0.42516106
39	MTOR	0.42362688
40	GRK1	0.41328924
41	CDK7	0.41068828
42	PINK1	0.38184785
43	SRPK1	0.38115039
44	MAP3K9	0.35219861
45	IRAK1	0.35179627
46	PDGFRB	0.32955426
47	MET	0.29905144
48	YES1	0.26674309
49	AURKB	0.26148099
50	BRSK1	0.24581203
51	TAOK1	0.22973524
52	CDK4	0.22386996
53	EIF2AK1	0.21574480
54	CDK2	0.20891304
55	MAP3K4	0.20883372
56	MAP3K3	0.20623284
57	CDK1	0.20113702
58	PAK1	0.19129427
59	ZAP70	0.18897428
60	PRKAA1	0.18857826
61	BUB1	0.18071100
62	TYK2	0.17031720
63	EEF2K	0.16496967
64	PAK2	0.16139865
65	STK4	0.15587399
66	RPS6KB1	0.12324079
67	CSNK2A1	0.11668662
68	EGFR	0.11261954
69	MAP2K7	0.11249134
70	STK10	0.11112407
71	EPHA2	0.10879313
72	TESK2	0.10319950
73	PDPK1	0.09950049
74	PRKDC	0.09423506
75	RIPK1	0.09385803
76	MAPK8	0.08964685
77	CSF1R	0.08769693
78	CSNK2A2	0.08262111
79	PAK4	0.06450334
80	PRKCI	0.06063036
81	MARK3	0.05659221
82	PRKCG	0.05170223
83	GSK3B	0.05163237
84	MAPK10	0.05045650
85	AURKA	0.04127904
86	MAP3K10	0.03988504
87	STK16	0.03979202
88	NEK1	0.02552953
89	ABL1	0.02002701
90	CSNK1D	0.01988079
91	PIM1	0.01975567
92	PTK6	0.01355598
93	MAP3K5	0.01259636
94	BRD4	0.00715909
95	PRKACB	0.00575360
96	INSR	0.00312722
97	CDK6	-0.0098937
98	CDK9	-0.0015639
99	MAP3K6	-0.0006784
100	MAPK1	-0.0003910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pentose phosphate pathway_Homo sapiens_hsa00030	4.40053660
2	Basal transcription factors_Homo sapiens_hsa03022	3.52857955
3	Pyruvate metabolism_Homo sapiens_hsa00620	3.49631371
4	Fanconi anemia pathway_Homo sapiens_hsa03460	3.39144468
5	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.37153631
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.27063679
7	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	3.19954011
8	Homologous recombination_Homo sapiens_hsa03440	2.94647125
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.88753590
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.48801944
11	RNA transport_Homo sapiens_hsa03013	2.45148221
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.21526974
13	Propanoate metabolism_Homo sapiens_hsa00640	2.17050590
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.14591991
15	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10688339
16	mRNA surveillance pathway_Homo sapiens_hsa03015	2.09182259
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.95539872
18	Oocyte meiosis_Homo sapiens_hsa04114	1.93959585
19	Glucagon signaling pathway_Homo sapiens_hsa04922	1.91597832
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.74971790
21	Glycerolipid metabolism_Homo sapiens_hsa00561	1.71232582
22	Huntingtons disease_Homo sapiens_hsa05016	1.65102596
23	Carbon metabolism_Homo sapiens_hsa01200	1.64391080
24	Proteasome_Homo sapiens_hsa03050	1.57556221
25	DNA replication_Homo sapiens_hsa03030	1.53535989
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.49286300
27	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.48594837
28	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.47014325
29	Cell cycle_Homo sapiens_hsa04110	1.46914165
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.30074278
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.28758921
32	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.17566624
33	Mismatch repair_Homo sapiens_hsa03430	1.11906561
34	Purine metabolism_Homo sapiens_hsa00230	1.09660880
35	PPAR signaling pathway_Homo sapiens_hsa03320	1.09212314
36	Spliceosome_Homo sapiens_hsa03040	1.09039734
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.08619970
38	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.04531674
39	RNA degradation_Homo sapiens_hsa03018	1.03433304
40	p53 signaling pathway_Homo sapiens_hsa04115	0.99315221
41	Glutathione metabolism_Homo sapiens_hsa00480	0.97643990
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95168226
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.94709961
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94599335
45	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.91330985
46	Base excision repair_Homo sapiens_hsa03410	0.88806996
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.88471343
48	Mineral absorption_Homo sapiens_hsa04978	0.87847795
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.87247063
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.85161891
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.82258947
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77412763
53	ABC transporters_Homo sapiens_hsa02010	0.74110217
54	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.70196797
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64065666
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.63975985
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.63349725
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.63269159
59	Legionellosis_Homo sapiens_hsa05134	0.62596064
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.61441457
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.61283285
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60119236
63	Amphetamine addiction_Homo sapiens_hsa05031	0.52459396
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.52273313
65	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.52258147
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51829784
67	Herpes simplex infection_Homo sapiens_hsa05168	0.51643609
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51096855
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48814425
70	Fatty acid degradation_Homo sapiens_hsa00071	0.47187020
71	Renin secretion_Homo sapiens_hsa04924	0.46846857
72	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46272489
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42254591
74	Lysine degradation_Homo sapiens_hsa00310	0.42237274
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40228591
76	Metabolic pathways_Homo sapiens_hsa01100	0.39744722
77	Influenza A_Homo sapiens_hsa05164	0.37866607
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.37255644
79	HTLV-I infection_Homo sapiens_hsa05166	0.32778439
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.31975314
81	VEGF signaling pathway_Homo sapiens_hsa04370	0.31932862
82	Retinol metabolism_Homo sapiens_hsa00830	0.28876191
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.27187874
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.26377381
85	Endocytosis_Homo sapiens_hsa04144	0.26224921
86	Estrogen signaling pathway_Homo sapiens_hsa04915	0.25141626
87	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.24842926
88	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.24225490
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.23619895
90	Alcoholism_Homo sapiens_hsa05034	0.22819226
91	Caffeine metabolism_Homo sapiens_hsa00232	0.22293533
92	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.21783623
93	RNA polymerase_Homo sapiens_hsa03020	0.15901582
94	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.12868192
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.12813867
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.12123000
97	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.11572222
98	Long-term potentiation_Homo sapiens_hsa04720	0.11328610
99	Toxoplasmosis_Homo sapiens_hsa05145	0.10782689
100	Salmonella infection_Homo sapiens_hsa05132	0.08449742

GML

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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