Rank | Gene Set | Z-score |
---|---|---|
1 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.34074014 |
2 | DNA replication checkpoint (GO:0000076) | 5.30508012 |
3 | telomere maintenance via semi-conservative replication (GO:0032201) | 5.14015001 |
4 | DNA replication initiation (GO:0006270) | 5.11811643 |
5 | mitotic metaphase plate congression (GO:0007080) | 5.10501784 |
6 | DNA strand elongation (GO:0022616) | 5.07590523 |
7 | telomere maintenance via recombination (GO:0000722) | 4.73404476 |
8 | CENP-A containing nucleosome assembly (GO:0034080) | 4.66652737 |
9 | protein localization to kinetochore (GO:0034501) | 4.66591795 |
10 | chromatin remodeling at centromere (GO:0031055) | 4.57403455 |
11 | purine nucleobase biosynthetic process (GO:0009113) | 4.56388376 |
12 | nucleobase biosynthetic process (GO:0046112) | 4.54205378 |
13 | establishment of integrated proviral latency (GO:0075713) | 4.53441235 |
14 | mitotic recombination (GO:0006312) | 4.48173044 |
15 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 4.34283617 |
16 | metaphase plate congression (GO:0051310) | 4.32774505 |
17 | DNA deamination (GO:0045006) | 4.23713544 |
18 | DNA unwinding involved in DNA replication (GO:0006268) | 4.19215300 |
19 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.19167660 |
20 | DNA replication-independent nucleosome organization (GO:0034724) | 4.19167660 |
21 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.18422328 |
22 | protein localization to chromosome, centromeric region (GO:0071459) | 4.13372669 |
23 | telomere maintenance via telomere lengthening (GO:0010833) | 4.08613376 |
24 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.06548334 |
25 | kinetochore organization (GO:0051383) | 4.03355990 |
26 | maturation of SSU-rRNA (GO:0030490) | 3.96633870 |
27 | histone exchange (GO:0043486) | 3.96011250 |
28 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.88882740 |
29 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.88882740 |
30 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.87254794 |
31 | negative regulation of ligase activity (GO:0051352) | 3.85745458 |
32 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.85745458 |
33 | establishment of chromosome localization (GO:0051303) | 3.83952284 |
34 | chaperone-mediated protein transport (GO:0072321) | 3.81212917 |
35 | kinetochore assembly (GO:0051382) | 3.81028792 |
36 | ribosome assembly (GO:0042255) | 3.79847219 |
37 | ribosomal small subunit assembly (GO:0000028) | 3.77916385 |
38 | ribosome biogenesis (GO:0042254) | 3.77460936 |
39 | formation of translation preinitiation complex (GO:0001731) | 3.76761068 |
40 | mitotic nuclear envelope disassembly (GO:0007077) | 3.75276513 |
41 | DNA ligation (GO:0006266) | 3.75127396 |
42 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.67982676 |
43 | mitotic chromosome condensation (GO:0007076) | 3.66114652 |
44 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.58232646 |
45 | regulation of spindle organization (GO:0090224) | 3.58208864 |
46 | IMP biosynthetic process (GO:0006188) | 3.54081663 |
47 | spliceosomal snRNP assembly (GO:0000387) | 3.51613797 |
48 | meiotic chromosome segregation (GO:0045132) | 3.51590833 |
49 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.51155881 |
50 | ATP synthesis coupled proton transport (GO:0015986) | 3.51155881 |
51 | mitotic sister chromatid segregation (GO:0000070) | 3.51128777 |
52 | establishment of viral latency (GO:0019043) | 3.50445823 |
53 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.49960174 |
54 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.47120812 |
55 | nuclear envelope disassembly (GO:0051081) | 3.44612603 |
56 | membrane disassembly (GO:0030397) | 3.44612603 |
57 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.42764185 |
58 | rRNA modification (GO:0000154) | 3.40735573 |
59 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.37898903 |
60 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.35954787 |
61 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.35354086 |
62 | regulation of mitochondrial translation (GO:0070129) | 3.35206771 |
63 | rRNA processing (GO:0006364) | 3.34281920 |
64 | DNA double-strand break processing (GO:0000729) | 3.34212423 |
65 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.33201191 |
66 | proteasome assembly (GO:0043248) | 3.32347375 |
67 | ribosomal large subunit biogenesis (GO:0042273) | 3.31748776 |
68 | mitotic spindle checkpoint (GO:0071174) | 3.29345374 |
69 | protein K6-linked ubiquitination (GO:0085020) | 3.29126320 |
70 | nuclear pore organization (GO:0006999) | 3.28693920 |
71 | cell cycle G1/S phase transition (GO:0044843) | 3.28544057 |
72 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.28544057 |
73 | spindle checkpoint (GO:0031577) | 3.28543985 |
74 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.28089707 |
75 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.26102156 |
76 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.25709538 |
77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.24792130 |
78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.24792130 |
79 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.24792130 |
80 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.24073484 |
81 | rRNA metabolic process (GO:0016072) | 3.23612490 |
82 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.22941256 |
83 | positive regulation of chromosome segregation (GO:0051984) | 3.22660283 |
84 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.22546432 |
85 | cullin deneddylation (GO:0010388) | 3.22538704 |
86 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.21691101 |
87 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.21691101 |
88 | termination of RNA polymerase III transcription (GO:0006386) | 3.21010031 |
89 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.21010031 |
90 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.19952457 |
91 | positive regulation of ligase activity (GO:0051351) | 3.19495852 |
92 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.19006285 |
93 | folic acid metabolic process (GO:0046655) | 3.18767180 |
94 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.18465882 |
95 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.18465882 |
96 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.17084690 |
97 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.17084690 |
98 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.16548524 |
99 | mitotic spindle assembly checkpoint (GO:0007094) | 3.16030304 |
100 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.15837642 |
101 | replication fork processing (GO:0031297) | 3.14537494 |
102 | maturation of 5.8S rRNA (GO:0000460) | 3.14449910 |
103 | regulation of chromosome segregation (GO:0051983) | 3.14148016 |
104 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.13393344 |
105 | IMP metabolic process (GO:0046040) | 3.12681572 |
106 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.12621491 |
107 | telomere organization (GO:0032200) | 3.12127589 |
108 | ribosomal small subunit biogenesis (GO:0042274) | 3.11815263 |
109 | pseudouridine synthesis (GO:0001522) | 3.11437787 |
110 | telomere maintenance (GO:0000723) | 3.11101160 |
111 | non-recombinational repair (GO:0000726) | 3.10549749 |
112 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.10549749 |
113 | 7-methylguanosine mRNA capping (GO:0006370) | 3.09834618 |
114 | mismatch repair (GO:0006298) | 3.09812759 |
115 | negative regulation of chromosome segregation (GO:0051985) | 3.09737114 |
116 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.09680048 |
117 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.08822335 |
118 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.08822335 |
119 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.08822335 |
120 | negative regulation of sister chromatid segregation (GO:0033046) | 3.08822335 |
121 | chromatin assembly or disassembly (GO:0006333) | 3.08787682 |
122 | regulation of ligase activity (GO:0051340) | 3.08013655 |
123 | sister chromatid segregation (GO:0000819) | 3.07811312 |
124 | DNA damage response, detection of DNA damage (GO:0042769) | 3.06864098 |
125 | translational termination (GO:0006415) | 3.06743224 |
126 | protein localization to chromosome (GO:0034502) | 3.06569757 |
127 | viral transcription (GO:0019083) | 3.06520000 |
128 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.06469674 |
129 | 7-methylguanosine RNA capping (GO:0009452) | 3.05487277 |
130 | RNA capping (GO:0036260) | 3.05487277 |
131 | chromosome segregation (GO:0007059) | 3.04444741 |
132 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.03437589 |
133 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.02231644 |
134 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.02231644 |
135 | spliceosomal complex assembly (GO:0000245) | 3.02147809 |
136 | spindle assembly checkpoint (GO:0071173) | 3.02108430 |
137 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.02001215 |
138 | ATP-dependent chromatin remodeling (GO:0043044) | 3.01885633 |
139 | translational initiation (GO:0006413) | 2.99688531 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.28008186 |
2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.22866625 |
3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.14770298 |
4 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.87582592 |
5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.59086571 |
6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.56677264 |
7 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.35068735 |
8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.09756883 |
9 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.06266610 |
10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.98169971 |
11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.88714458 |
12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.88255465 |
13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.87605903 |
14 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.81282058 |
15 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.78898307 |
16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.53116365 |
17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.45881667 |
18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.39591557 |
19 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.34722576 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32701948 |
21 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.28992448 |
22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.28823518 |
23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.28246514 |
24 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04395164 |
25 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.04195624 |
26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.03265861 |
27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.02879569 |
28 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.95051800 |
29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.94958443 |
30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.91701152 |
31 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.89106066 |
32 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.88784948 |
33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.85804417 |
34 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.82063834 |
35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.81368352 |
36 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.80908854 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.78631807 |
38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.76647858 |
39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75980091 |
40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.71966118 |
41 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70311861 |
42 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.69257148 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.63964091 |
44 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.62120736 |
45 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.61845719 |
46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.61525681 |
47 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.52503155 |
48 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49646521 |
49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47548766 |
50 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.46081666 |
51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.42158335 |
52 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39106240 |
53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.37755089 |
54 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.36771102 |
55 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.35766040 |
56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25230301 |
57 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.25167201 |
58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.21549678 |
59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.20495842 |
60 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.20166187 |
61 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.19948214 |
62 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18881159 |
63 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.17495968 |
64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.17263997 |
65 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.16318078 |
66 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.15768095 |
67 | MYC_22102868_ChIP-Seq_BL_Human | 1.14740222 |
68 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.11956900 |
69 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.10520018 |
70 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09063645 |
71 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.05897572 |
72 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.05279029 |
73 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.03180500 |
74 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.02946746 |
75 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01818007 |
76 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.99547648 |
77 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.98320336 |
78 | * MYC_18940864_ChIP-ChIP_HL60_Human | 0.97957375 |
79 | * TFEB_21752829_ChIP-Seq_HELA_Human | 0.97183500 |
80 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.96835820 |
81 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96775109 |
82 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.96185485 |
83 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.94783655 |
84 | EWS_26573619_Chip-Seq_HEK293_Human | 0.94287436 |
85 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94229446 |
86 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.92548503 |
87 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92409193 |
88 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91033364 |
89 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.89546688 |
90 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89439810 |
91 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87137918 |
92 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85573663 |
93 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.83639870 |
94 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.82276947 |
95 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81662431 |
96 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.81622914 |
97 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.81295984 |
98 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.78929263 |
99 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.78610931 |
100 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.78213589 |
101 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.77932073 |
102 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.75325886 |
103 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.74142267 |
104 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.73484953 |
105 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.72353973 |
106 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.72220637 |
107 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.71869423 |
108 | FUS_26573619_Chip-Seq_HEK293_Human | 0.71126588 |
109 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.70782001 |
110 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.70473732 |
111 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.70018107 |
112 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.69181333 |
113 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.68538790 |
114 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.68066277 |
115 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.67463993 |
116 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.64222014 |
117 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.63750720 |
118 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.63659134 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 6.35269123 |
2 | MP0010094_abnormal_chromosome_stability | 5.19451113 |
3 | * MP0003111_abnormal_nucleus_morphology | 4.78359279 |
4 | MP0008057_abnormal_DNA_replication | 4.68586592 |
5 | * MP0004957_abnormal_blastocyst_morpholog | 4.58738762 |
6 | * MP0003077_abnormal_cell_cycle | 4.30734795 |
7 | MP0008058_abnormal_DNA_repair | 3.80059239 |
8 | MP0008007_abnormal_cellular_replicative | 3.05258787 |
9 | MP0008932_abnormal_embryonic_tissue | 2.92073318 |
10 | MP0008877_abnormal_DNA_methylation | 2.56679909 |
11 | MP0003123_paternal_imprinting | 2.43461645 |
12 | MP0002396_abnormal_hematopoietic_system | 2.33280840 |
13 | * MP0001730_embryonic_growth_arrest | 2.32831316 |
14 | MP0003718_maternal_effect | 2.25228209 |
15 | * MP0000350_abnormal_cell_proliferation | 2.21361507 |
16 | MP0003786_premature_aging | 2.10122512 |
17 | MP0010307_abnormal_tumor_latency | 1.88335355 |
18 | MP0000490_abnormal_crypts_of | 1.76228756 |
19 | MP0003806_abnormal_nucleotide_metabolis | 1.72891621 |
20 | MP0001697_abnormal_embryo_size | 1.71202722 |
21 | * MP0001672_abnormal_embryogenesis/_devel | 1.71171577 |
22 | * MP0005380_embryogenesis_phenotype | 1.71171577 |
23 | * MP0002080_prenatal_lethality | 1.56452696 |
24 | MP0003984_embryonic_growth_retardation | 1.56430086 |
25 | MP0000313_abnormal_cell_death | 1.53689016 |
26 | MP0010352_gastrointestinal_tract_polyps | 1.52308439 |
27 | MP0002088_abnormal_embryonic_growth/wei | 1.51497490 |
28 | MP0009333_abnormal_splenocyte_physiolog | 1.48979641 |
29 | MP0002019_abnormal_tumor_incidence | 1.48097569 |
30 | MP0002210_abnormal_sex_determination | 1.47670218 |
31 | MP0002938_white_spotting | 1.47110282 |
32 | MP0003136_yellow_coat_color | 1.43666418 |
33 | * MP0002085_abnormal_embryonic_tissue | 1.41681377 |
34 | MP0003567_abnormal_fetal_cardiomyocyte | 1.36932669 |
35 | MP0003315_abnormal_perineum_morphology | 1.34830980 |
36 | MP0003186_abnormal_redox_activity | 1.32928366 |
37 | MP0009379_abnormal_foot_pigmentation | 1.29851188 |
38 | MP0001145_abnormal_male_reproductive | 1.26003058 |
39 | MP0006292_abnormal_olfactory_placode | 1.25723611 |
40 | MP0001929_abnormal_gametogenesis | 1.25670268 |
41 | MP0004808_abnormal_hematopoietic_stem | 1.24992334 |
42 | MP0000372_irregular_coat_pigmentation | 1.23966836 |
43 | MP0001529_abnormal_vocalization | 1.22849647 |
44 | MP0002084_abnormal_developmental_patter | 1.22044010 |
45 | MP0005397_hematopoietic_system_phenotyp | 1.21902500 |
46 | MP0001545_abnormal_hematopoietic_system | 1.21902500 |
47 | * MP0002086_abnormal_extraembryonic_tissu | 1.21689647 |
48 | MP0008789_abnormal_olfactory_epithelium | 1.16285775 |
49 | MP0006072_abnormal_retinal_apoptosis | 1.15933047 |
50 | MP0003221_abnormal_cardiomyocyte_apopto | 1.14043283 |
51 | MP0000653_abnormal_sex_gland | 1.13295371 |
52 | MP0006036_abnormal_mitochondrial_physio | 1.12414928 |
53 | MP0004197_abnormal_fetal_growth/weight/ | 1.07768178 |
54 | MP0001286_abnormal_eye_development | 1.03873513 |
55 | MP0002160_abnormal_reproductive_system | 1.03205636 |
56 | MP0003121_genomic_imprinting | 1.02575303 |
57 | MP0002697_abnormal_eye_size | 1.02232872 |
58 | MP0001119_abnormal_female_reproductive | 1.01820001 |
59 | MP0003890_abnormal_embryonic-extraembry | 0.99616597 |
60 | MP0003763_abnormal_thymus_physiology | 0.97828369 |
61 | MP0000689_abnormal_spleen_morphology | 0.95333196 |
62 | * MP0002398_abnormal_bone_marrow | 0.94928533 |
63 | MP0002722_abnormal_immune_system | 0.94903410 |
64 | MP0002132_abnormal_respiratory_system | 0.93276468 |
65 | MP0001293_anophthalmia | 0.92976306 |
66 | MP0000358_abnormal_cell_content/ | 0.91134111 |
67 | * MP0000703_abnormal_thymus_morphology | 0.87381819 |
68 | MP0002233_abnormal_nose_morphology | 0.87114194 |
69 | MP0002102_abnormal_ear_morphology | 0.84229493 |
70 | MP0000049_abnormal_middle_ear | 0.82338611 |
71 | MP0005389_reproductive_system_phenotype | 0.81834586 |
72 | MP0005451_abnormal_body_composition | 0.80599561 |
73 | MP0009672_abnormal_birth_weight | 0.79491299 |
74 | MP0003656_abnormal_erythrocyte_physiolo | 0.78984109 |
75 | * MP0002429_abnormal_blood_cell | 0.78168277 |
76 | MP0001346_abnormal_lacrimal_gland | 0.77454205 |
77 | MP0001188_hyperpigmentation | 0.76693747 |
78 | MP0000647_abnormal_sebaceous_gland | 0.76235379 |
79 | * MP0005384_cellular_phenotype | 0.75537437 |
80 | MP0005499_abnormal_olfactory_system | 0.74713520 |
81 | MP0005394_taste/olfaction_phenotype | 0.74713520 |
82 | MP0003941_abnormal_skin_development | 0.74561440 |
83 | MP0006035_abnormal_mitochondrial_morpho | 0.74450131 |
84 | MP0002234_abnormal_pharynx_morphology | 0.72548766 |
85 | MP0001661_extended_life_span | 0.71272513 |
86 | MP0000858_altered_metastatic_potential | 0.71111119 |
87 | MP0004147_increased_porphyrin_level | 0.71058841 |
88 | MP0005266_abnormal_metabolism | 0.69934716 |
89 | * MP0005621_abnormal_cell_physiology | 0.69632482 |
90 | MP0008260_abnormal_autophagy | 0.69243008 |
91 | MP0001853_heart_inflammation | 0.68773716 |
92 | MP0002163_abnormal_gland_morphology | 0.68150411 |
93 | MP0005408_hypopigmentation | 0.67973948 |
94 | MP0003699_abnormal_female_reproductive | 0.65293665 |
95 | MP0006054_spinal_hemorrhage | 0.65250642 |
96 | MP0002653_abnormal_ependyma_morphology | 0.64616015 |
97 | MP0003937_abnormal_limbs/digits/tail_de | 0.64435560 |
98 | MP0000537_abnormal_urethra_morphology | 0.64428564 |
99 | MP0002736_abnormal_nociception_after | 0.63771031 |
100 | MP0005391_vision/eye_phenotype | 0.63698680 |
101 | MP0002090_abnormal_vision | 0.63498269 |
102 | * MP0000716_abnormal_immune_system | 0.61490724 |
103 | MP0003119_abnormal_digestive_system | 0.61394231 |
104 | MP0002092_abnormal_eye_morphology | 0.60807541 |
105 | MP0004084_abnormal_cardiac_muscle | 0.60444526 |
106 | MP0005395_other_phenotype | 0.60358118 |
107 | MP0005084_abnormal_gallbladder_morpholo | 0.60079291 |
108 | MP0003646_muscle_fatigue | 0.59121192 |
109 | MP0003698_abnormal_male_reproductive | 0.58941511 |
110 | MP0000579_abnormal_nail_morphology | 0.58420906 |
111 | MP0002111_abnormal_tail_morphology | 0.57877202 |
112 | MP0002161_abnormal_fertility/fecundity | 0.57299017 |
113 | MP0005253_abnormal_eye_physiology | 0.56155747 |
114 | MP0001881_abnormal_mammary_gland | 0.56129791 |
115 | MP0003755_abnormal_palate_morphology | 0.55793013 |
116 | MP0008995_early_reproductive_senescence | 0.55429082 |
117 | MP0004133_heterotaxia | 0.54766279 |
118 | MP0010030_abnormal_orbit_morphology | 0.54243494 |
119 | MP0003861_abnormal_nervous_system | 0.53348474 |
120 | MP0000477_abnormal_intestine_morphology | 0.52408706 |
121 | MP0001727_abnormal_embryo_implantation | 0.52015071 |
122 | MP0009053_abnormal_anal_canal | 0.51891393 |
123 | MP0005075_abnormal_melanosome_morpholog | 0.51791880 |
124 | MP0005501_abnormal_skin_physiology | 0.51713183 |
125 | MP0000631_abnormal_neuroendocrine_gland | 0.50801457 |
126 | MP0001764_abnormal_homeostasis | 0.49330557 |
127 | MP0009697_abnormal_copulation | 0.49221598 |
128 | MP0001919_abnormal_reproductive_system | 0.48881158 |
129 | MP0000750_abnormal_muscle_regeneration | 0.48555602 |
130 | MP0001915_intracranial_hemorrhage | 0.47653844 |
131 | MP0009703_decreased_birth_body | 0.46320378 |
132 | MP0002095_abnormal_skin_pigmentation | 0.46149348 |
133 | MP0004264_abnormal_extraembryonic_tissu | 0.43893250 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 6.53602723 |
2 | Breast hypoplasia (HP:0003187) | 5.14254514 |
3 | Chromsome breakage (HP:0040012) | 4.49502357 |
4 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.40743471 |
5 | Reticulocytopenia (HP:0001896) | 4.12726276 |
6 | Patellar aplasia (HP:0006443) | 4.01880787 |
7 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.01570620 |
8 | Acute necrotizing encephalopathy (HP:0006965) | 3.99425261 |
9 | Abnormal number of erythroid precursors (HP:0012131) | 3.98140745 |
10 | Oral leukoplakia (HP:0002745) | 3.94552119 |
11 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.79306343 |
12 | Acute encephalopathy (HP:0006846) | 3.74003138 |
13 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.73341189 |
14 | Carpal bone hypoplasia (HP:0001498) | 3.71991115 |
15 | Meckel diverticulum (HP:0002245) | 3.68083381 |
16 | Abnormality of chromosome stability (HP:0003220) | 3.63562933 |
17 | Abnormality of the preputium (HP:0100587) | 3.61151283 |
18 | Abnormality of the ileum (HP:0001549) | 3.46440955 |
19 | Mitochondrial inheritance (HP:0001427) | 3.34534616 |
20 | Increased CSF lactate (HP:0002490) | 3.32418164 |
21 | Aplastic anemia (HP:0001915) | 3.29746969 |
22 | Increased hepatocellular lipid droplets (HP:0006565) | 3.28697790 |
23 | Impulsivity (HP:0100710) | 3.24408811 |
24 | Rough bone trabeculation (HP:0100670) | 3.22308981 |
25 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.21006323 |
26 | Progressive macrocephaly (HP:0004481) | 3.15921486 |
27 | Cerebral hypomyelination (HP:0006808) | 3.12849691 |
28 | Degeneration of anterior horn cells (HP:0002398) | 3.08626819 |
29 | Abnormality of the anterior horn cell (HP:0006802) | 3.08626819 |
30 | Colon cancer (HP:0003003) | 3.01448217 |
31 | Hepatocellular necrosis (HP:0001404) | 2.95054989 |
32 | Microretrognathia (HP:0000308) | 2.94785334 |
33 | Cerebral edema (HP:0002181) | 2.92992354 |
34 | Lipid accumulation in hepatocytes (HP:0006561) | 2.89752927 |
35 | Duodenal stenosis (HP:0100867) | 2.88680205 |
36 | Small intestinal stenosis (HP:0012848) | 2.88680205 |
37 | Absent radius (HP:0003974) | 2.87907252 |
38 | Selective tooth agenesis (HP:0001592) | 2.87684372 |
39 | Bone marrow hypocellularity (HP:0005528) | 2.83794459 |
40 | Macrocytic anemia (HP:0001972) | 2.81295556 |
41 | Absent thumb (HP:0009777) | 2.79475168 |
42 | Increased serum pyruvate (HP:0003542) | 2.78560061 |
43 | Hepatic necrosis (HP:0002605) | 2.75519251 |
44 | Myelodysplasia (HP:0002863) | 2.74694970 |
45 | Agnosia (HP:0010524) | 2.73706356 |
46 | Multiple enchondromatosis (HP:0005701) | 2.72709688 |
47 | Medulloblastoma (HP:0002885) | 2.69314411 |
48 | Abnormality of glycolysis (HP:0004366) | 2.66987761 |
49 | Aplasia involving forearm bones (HP:0009822) | 2.66788670 |
50 | Absent forearm bone (HP:0003953) | 2.66788670 |
51 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.59660789 |
52 | Premature graying of hair (HP:0002216) | 2.59473035 |
53 | Microvesicular hepatic steatosis (HP:0001414) | 2.58951820 |
54 | Pallor (HP:0000980) | 2.50465236 |
55 | Horseshoe kidney (HP:0000085) | 2.47493222 |
56 | Secondary amenorrhea (HP:0000869) | 2.47274617 |
57 | Abnormal spermatogenesis (HP:0008669) | 2.45395922 |
58 | Neoplasm of the pancreas (HP:0002894) | 2.44965984 |
59 | Ependymoma (HP:0002888) | 2.44531544 |
60 | Sloping forehead (HP:0000340) | 2.37767416 |
61 | Cleft eyelid (HP:0000625) | 2.36252815 |
62 | Cellular immunodeficiency (HP:0005374) | 2.35821058 |
63 | Ectopic kidney (HP:0000086) | 2.35564037 |
64 | Lactic acidosis (HP:0003128) | 2.35473929 |
65 | Tracheoesophageal fistula (HP:0002575) | 2.35165539 |
66 | Renal Fanconi syndrome (HP:0001994) | 2.35086348 |
67 | Abnormality of the labia minora (HP:0012880) | 2.34476915 |
68 | Abnormal lung lobation (HP:0002101) | 2.33576576 |
69 | Abnormality of methionine metabolism (HP:0010901) | 2.33412480 |
70 | Triphalangeal thumb (HP:0001199) | 2.30840342 |
71 | Abnormal trabecular bone morphology (HP:0100671) | 2.30523373 |
72 | Abnormality of the duodenum (HP:0002246) | 2.30061243 |
73 | 11 pairs of ribs (HP:0000878) | 2.28570094 |
74 | Duplicated collecting system (HP:0000081) | 2.28437338 |
75 | Premature ovarian failure (HP:0008209) | 2.28311892 |
76 | Pancytopenia (HP:0001876) | 2.26791318 |
77 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.25941081 |
78 | Hyperglycinemia (HP:0002154) | 2.24495990 |
79 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.20758551 |
80 | Embryonal renal neoplasm (HP:0011794) | 2.19710233 |
81 | Increased intramyocellular lipid droplets (HP:0012240) | 2.19188600 |
82 | Increased nuchal translucency (HP:0010880) | 2.19055354 |
83 | Supernumerary spleens (HP:0009799) | 2.18680376 |
84 | Slender long bone (HP:0003100) | 2.17790860 |
85 | Abnormality of serum amino acid levels (HP:0003112) | 2.17424759 |
86 | Rhabdomyosarcoma (HP:0002859) | 2.15975735 |
87 | Clubbing of toes (HP:0100760) | 2.14064106 |
88 | Atresia of the external auditory canal (HP:0000413) | 2.13856498 |
89 | Trismus (HP:0000211) | 2.13486058 |
90 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.12815281 |
91 | Short thumb (HP:0009778) | 2.11924635 |
92 | Leukodystrophy (HP:0002415) | 2.11829779 |
93 | Exercise intolerance (HP:0003546) | 2.08560652 |
94 | Respiratory failure (HP:0002878) | 2.07257573 |
95 | Facial cleft (HP:0002006) | 2.07162800 |
96 | Facial hemangioma (HP:0000329) | 2.07000305 |
97 | Squamous cell carcinoma (HP:0002860) | 2.05744220 |
98 | Abnormality of the carotid arteries (HP:0005344) | 2.05469041 |
99 | Volvulus (HP:0002580) | 2.04475057 |
100 | Abnormality of the renal collecting system (HP:0004742) | 2.03684186 |
101 | Megaloblastic anemia (HP:0001889) | 2.02713671 |
102 | Respiratory difficulties (HP:0002880) | 2.01940886 |
103 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.98784425 |
104 | Progressive muscle weakness (HP:0003323) | 1.98314302 |
105 | Abnormal number of incisors (HP:0011064) | 1.97405507 |
106 | Lymphoma (HP:0002665) | 1.95533434 |
107 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.95235289 |
108 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.95235289 |
109 | Breast aplasia (HP:0100783) | 1.95000060 |
110 | Ureteral duplication (HP:0000073) | 1.93300043 |
111 | Reduced antithrombin III activity (HP:0001976) | 1.93033459 |
112 | Increased serum lactate (HP:0002151) | 1.92048099 |
113 | Cafe-au-lait spot (HP:0000957) | 1.90545228 |
114 | CNS hypomyelination (HP:0003429) | 1.89404192 |
115 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.88595559 |
116 | 3-Methylglutaconic aciduria (HP:0003535) | 1.88443665 |
117 | Abnormality of cochlea (HP:0000375) | 1.87420307 |
118 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85598816 |
119 | Methylmalonic acidemia (HP:0002912) | 1.84593924 |
120 | Postnatal microcephaly (HP:0005484) | 1.84098230 |
121 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.83785460 |
122 | Abnormality of alanine metabolism (HP:0010916) | 1.83233792 |
123 | Hyperalaninemia (HP:0003348) | 1.83233792 |
124 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.83233792 |
125 | Methylmalonic aciduria (HP:0012120) | 1.82035282 |
126 | Abnormality of reticulocytes (HP:0004312) | 1.81357939 |
127 | Abnormal protein glycosylation (HP:0012346) | 1.81074715 |
128 | Abnormal glycosylation (HP:0012345) | 1.81074715 |
129 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.81074715 |
130 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.81074715 |
131 | Sparse eyelashes (HP:0000653) | 1.80885194 |
132 | Lethargy (HP:0001254) | 1.79683067 |
133 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.78625543 |
134 | Exertional dyspnea (HP:0002875) | 1.78619392 |
135 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.78138861 |
136 | Nausea (HP:0002018) | 1.77439255 |
137 | Cortical dysplasia (HP:0002539) | 1.77103905 |
138 | Basal cell carcinoma (HP:0002671) | 1.76190645 |
139 | Poor head control (HP:0002421) | 1.75982593 |
140 | Type I transferrin isoform profile (HP:0003642) | 1.74182285 |
141 | Hypoplasia of the radius (HP:0002984) | 1.73298106 |
142 | Muscle fiber atrophy (HP:0100295) | 1.72806789 |
143 | Neoplasm of the colon (HP:0100273) | 1.72633173 |
144 | Azoospermia (HP:0000027) | 1.72192715 |
145 | Thrombocytosis (HP:0001894) | 1.71875343 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WEE1 | 4.99652519 |
2 | BUB1 | 4.88644972 |
3 | CDC7 | 4.49163624 |
4 | VRK2 | 3.48048745 |
5 | EIF2AK1 | 3.46645189 |
6 | PLK4 | 2.98350211 |
7 | SRPK1 | 2.90096945 |
8 | NEK2 | 2.85830645 |
9 | BRSK2 | 2.77492350 |
10 | NME2 | 2.57218461 |
11 | ACVR1B | 2.54875824 |
12 | TTK | 2.50323999 |
13 | NEK1 | 2.41046394 |
14 | EIF2AK3 | 2.26381386 |
15 | PLK1 | 2.24464917 |
16 | STK16 | 2.05582248 |
17 | VRK1 | 2.04311536 |
18 | AURKB | 1.81646819 |
19 | BRSK1 | 1.80085578 |
20 | TSSK6 | 1.69808293 |
21 | TRIM28 | 1.68943362 |
22 | CCNB1 | 1.68505601 |
23 | PLK3 | 1.68391519 |
24 | TESK2 | 1.66881223 |
25 | DYRK3 | 1.64373950 |
26 | CDK7 | 1.63607356 |
27 | ATR | 1.57790533 |
28 | CHEK2 | 1.53777962 |
29 | MKNK1 | 1.53682135 |
30 | TAF1 | 1.41783444 |
31 | NUAK1 | 1.39136091 |
32 | RPS6KA4 | 1.38011491 |
33 | TLK1 | 1.36789431 |
34 | PDK2 | 1.33599634 |
35 | PASK | 1.28061457 |
36 | CDK4 | 1.27265606 |
37 | MAP3K8 | 1.25978435 |
38 | MKNK2 | 1.24455659 |
39 | STK4 | 1.22657792 |
40 | CHEK1 | 1.17244972 |
41 | ZAK | 1.10714372 |
42 | RPS6KB2 | 1.08353459 |
43 | * AURKA | 1.03737053 |
44 | EIF2AK2 | 0.95784775 |
45 | STK38L | 0.93868846 |
46 | BMPR1B | 0.93818528 |
47 | STK10 | 0.89232937 |
48 | SCYL2 | 0.87909231 |
49 | BRAF | 0.87789552 |
50 | TNIK | 0.86327617 |
51 | PBK | 0.82652274 |
52 | PIM1 | 0.81958087 |
53 | ATM | 0.81358612 |
54 | EPHA2 | 0.81193087 |
55 | CDK2 | 0.77130861 |
56 | WNK3 | 0.76686776 |
57 | PAK4 | 0.75307651 |
58 | CDK8 | 0.72737084 |
59 | PIM2 | 0.70918472 |
60 | MELK | 0.69616460 |
61 | CSNK1G1 | 0.67411522 |
62 | * CSNK2A1 | 0.66926891 |
63 | CSNK2A2 | 0.64479629 |
64 | PAK1 | 0.63966511 |
65 | STK3 | 0.62962771 |
66 | CSNK1G3 | 0.62799972 |
67 | DYRK2 | 0.61636749 |
68 | CDK1 | 0.60423269 |
69 | LATS2 | 0.60416485 |
70 | CLK1 | 0.57513740 |
71 | ABL2 | 0.57361881 |
72 | BCKDK | 0.56411601 |
73 | DAPK1 | 0.54780133 |
74 | TGFBR1 | 0.54730342 |
75 | CDK12 | 0.54129261 |
76 | KDR | 0.53826330 |
77 | PLK2 | 0.53430287 |
78 | MAP4K2 | 0.53232902 |
79 | PRKCI | 0.51184209 |
80 | CSNK1G2 | 0.46336044 |
81 | MAP2K3 | 0.45981333 |
82 | PDK3 | 0.44516136 |
83 | PDK4 | 0.44516136 |
84 | RPS6KA5 | 0.44273051 |
85 | CSNK1A1L | 0.42695092 |
86 | MAP4K1 | 0.42327754 |
87 | BCR | 0.41891595 |
88 | ERBB4 | 0.41667096 |
89 | NME1 | 0.41280328 |
90 | IRAK3 | 0.41184891 |
91 | MAP3K10 | 0.41109079 |
92 | TESK1 | 0.40840916 |
93 | CDK6 | 0.40605747 |
94 | ALK | 0.40483516 |
95 | FLT3 | 0.40155642 |
96 | STK24 | 0.39690456 |
97 | MST4 | 0.38726456 |
98 | NEK9 | 0.38600329 |
99 | CDK3 | 0.37004272 |
100 | LRRK2 | 0.36683604 |
101 | MAP3K11 | 0.36604432 |
102 | ERBB3 | 0.33574354 |
103 | MAP3K12 | 0.33070319 |
104 | IRAK4 | 0.31896775 |
105 | FGFR1 | 0.31543976 |
106 | TEC | 0.29908559 |
107 | MAP3K6 | 0.29856926 |
108 | CDK18 | 0.29459280 |
109 | TYK2 | 0.29016575 |
110 | MARK3 | 0.28203069 |
111 | MAPKAPK3 | 0.27976214 |
112 | CDK11A | 0.26969412 |
113 | CDK15 | 0.26947001 |
114 | OXSR1 | 0.26889198 |
115 | CDK14 | 0.26277214 |
116 | MAP3K5 | 0.25443036 |
117 | CDK9 | 0.25006804 |
118 | PNCK | 0.23655749 |
119 | RAF1 | 0.23102958 |
120 | AKT2 | 0.21962936 |
121 | MAPKAPK5 | 0.21717274 |
122 | PRKDC | 0.21690697 |
123 | BRD4 | 0.21237292 |
124 | CSNK1E | 0.20009000 |
125 | STK39 | 0.20008315 |
126 | EEF2K | 0.20002610 |
127 | SMG1 | 0.19692045 |
128 | MAP3K3 | 0.19430824 |
129 | ILK | 0.17499825 |
130 | TAOK2 | 0.15887280 |
131 | YES1 | 0.15166266 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 5.44147349 |
2 | Mismatch repair_Homo sapiens_hsa03430 | 4.47190385 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 3.67446612 |
4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.65875889 |
5 | Proteasome_Homo sapiens_hsa03050 | 3.46350653 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 3.40610448 |
7 | Ribosome_Homo sapiens_hsa03010 | 3.23973983 |
8 | Spliceosome_Homo sapiens_hsa03040 | 3.13077092 |
9 | Base excision repair_Homo sapiens_hsa03410 | 3.10474354 |
10 | RNA transport_Homo sapiens_hsa03013 | 2.99741616 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.98426924 |
12 | Cell cycle_Homo sapiens_hsa04110 | 2.89362960 |
13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.77762915 |
14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.44056089 |
15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.39552456 |
16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.12402354 |
17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.09065173 |
18 | RNA degradation_Homo sapiens_hsa03018 | 1.91397800 |
19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.89292563 |
20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.65375011 |
21 | Purine metabolism_Homo sapiens_hsa00230 | 1.53676423 |
22 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.46941022 |
23 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.44977557 |
24 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.37280205 |
25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.27150520 |
26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.21664685 |
27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.16274579 |
28 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.13392049 |
29 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.10989841 |
30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10469283 |
31 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08988966 |
32 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.08033174 |
33 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.01352771 |
34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97236820 |
35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94543150 |
36 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.90945093 |
37 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.90327239 |
38 | Huntingtons disease_Homo sapiens_hsa05016 | 0.88840977 |
39 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.86739944 |
40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.85406276 |
41 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.85088494 |
42 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.83688332 |
43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79080470 |
44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.77819824 |
45 | Protein export_Homo sapiens_hsa03060 | 0.76947468 |
46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.72403202 |
47 | Parkinsons disease_Homo sapiens_hsa05012 | 0.70615530 |
48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.70197464 |
49 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69980870 |
50 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67396592 |
51 | Sulfur relay system_Homo sapiens_hsa04122 | 0.63220705 |
52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60413716 |
53 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.59904272 |
54 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.59703573 |
55 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.59636661 |
56 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58075972 |
57 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.55800065 |
58 | HTLV-I infection_Homo sapiens_hsa05166 | 0.54026870 |
59 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53052167 |
60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.52167504 |
61 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.51085590 |
62 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48739906 |
63 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.44567166 |
64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42635120 |
65 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42602069 |
66 | Thyroid cancer_Homo sapiens_hsa05216 | 0.41702610 |
67 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.41675603 |
68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.41531158 |
69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.41184604 |
70 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.40935565 |
71 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.40782138 |
72 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.39108992 |
73 | Peroxisome_Homo sapiens_hsa04146 | 0.38894019 |
74 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38355219 |
75 | Legionellosis_Homo sapiens_hsa05134 | 0.37127127 |
76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.36519596 |
77 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.35034868 |
78 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.34605307 |
79 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.31300024 |
80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.29095383 |
81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.29055414 |
82 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.28617442 |
83 | Apoptosis_Homo sapiens_hsa04210 | 0.28538348 |
84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27454029 |
85 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26302155 |
86 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.25907233 |
87 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25568226 |
88 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.25048774 |
89 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.24212525 |
90 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.23980403 |
91 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.21721583 |
92 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.19863025 |
93 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.19666359 |
94 | Measles_Homo sapiens_hsa05162 | 0.19617140 |
95 | Hepatitis B_Homo sapiens_hsa05161 | 0.19368291 |
96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.19116325 |
97 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.19095935 |
98 | Lysine degradation_Homo sapiens_hsa00310 | 0.18759521 |
99 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.18213907 |
100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16446751 |
101 | Retinol metabolism_Homo sapiens_hsa00830 | 0.14988177 |
102 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.14938290 |
103 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.14842811 |
104 | Shigellosis_Homo sapiens_hsa05131 | 0.14702986 |
105 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.14657200 |
106 | Alzheimers disease_Homo sapiens_hsa05010 | 0.13157060 |
107 | Influenza A_Homo sapiens_hsa05164 | 0.11803937 |
108 | Alcoholism_Homo sapiens_hsa05034 | 0.11701477 |
109 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.11412400 |
110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.11179114 |
111 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.11178520 |
112 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.10703639 |
113 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.09892211 |
114 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.09622336 |
115 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.08895923 |
116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.07735961 |
117 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.07458570 |
118 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.07420529 |
119 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.07392705 |
120 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.07354512 |
121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.07308995 |
122 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.06846592 |
123 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.06499899 |
124 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.05517523 |
125 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.05047075 |
126 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.04594439 |
127 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.03815432 |
128 | Pathways in cancer_Homo sapiens_hsa05200 | 0.03634596 |
129 | Bladder cancer_Homo sapiens_hsa05219 | 0.02250060 |
130 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | -0.0117100 |
131 | Basal cell carcinoma_Homo sapiens_hsa05217 | -0.0116276 |