GMPPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.63818593
2protein retention in ER lumen (GO:0006621)7.14402573
3signal peptide processing (GO:0006465)6.98791136
4COPII vesicle coating (GO:0048208)6.12085835
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.89104409
6protein maturation by protein folding (GO:0022417)5.80794257
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.74781042
8exocrine pancreas development (GO:0031017)5.69417819
9positive regulation of nuclease activity (GO:0032075)5.53533007
10regulation of nuclease activity (GO:0032069)5.05186800
11endoplasmic reticulum unfolded protein response (GO:0030968)5.00994283
12cellular response to unfolded protein (GO:0034620)4.85483264
13cellular response to topologically incorrect protein (GO:0035967)4.77879265
14ER-nucleus signaling pathway (GO:0006984)4.51398360
15ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.49621710
16sequestering of metal ion (GO:0051238)4.47961613
17endocrine pancreas development (GO:0031018)4.32543414
18* protein N-linked glycosylation via asparagine (GO:0018279)4.28866984
19vesicle coating (GO:0006901)4.26049463
20* peptidyl-asparagine modification (GO:0018196)4.24718311
21intestinal cholesterol absorption (GO:0030299)4.10254424
22response to endoplasmic reticulum stress (GO:0034976)4.06460282
23* protein N-linked glycosylation (GO:0006487)3.93029081
24proline biosynthetic process (GO:0006561)3.92539615
254-hydroxyproline metabolic process (GO:0019471)3.87583748
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86587063
27peptide hormone processing (GO:0016486)3.85508645
28response to unfolded protein (GO:0006986)3.80426451
29response to topologically incorrect protein (GO:0035966)3.74443716
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.72107438
31regulation of type B pancreatic cell apoptotic process (GO:2000674)3.67223076
32UDP-N-acetylglucosamine metabolic process (GO:0006047)3.62779595
33pinocytosis (GO:0006907)3.57618980
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56868578
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56868578
36ER to Golgi vesicle-mediated transport (GO:0006888)3.47607946
37glandular epithelial cell differentiation (GO:0002067)3.44907230
38peptide catabolic process (GO:0043171)3.43503182
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40303201
40L-alpha-amino acid transmembrane transport (GO:1902475)3.35391862
41protein targeting to ER (GO:0045047)3.31336168
42cotranslational protein targeting to membrane (GO:0006613)3.26933744
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17681752
44protein localization to endoplasmic reticulum (GO:0070972)3.16737843
45tricarboxylic acid metabolic process (GO:0072350)3.16680686
46galactose catabolic process (GO:0019388)3.07261040
47misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.05071521
48antigen processing and presentation of endogenous antigen (GO:0019883)3.05067772
49valine metabolic process (GO:0006573)3.01997148
50negative regulation of glycoprotein biosynthetic process (GO:0010561)3.01537766
51* GDP-mannose metabolic process (GO:0019673)2.98697392
52cell redox homeostasis (GO:0045454)2.97964013
53purine nucleotide salvage (GO:0032261)2.93398338
54intestinal absorption (GO:0050892)2.89601738
55mannose metabolic process (GO:0006013)2.89020920
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87041986
57peptidyl-proline hydroxylation (GO:0019511)2.86303830
58peptidyl-glutamic acid carboxylation (GO:0017187)2.84996944
59protein carboxylation (GO:0018214)2.84996944
60adhesion of symbiont to host (GO:0044406)2.84557672
61digestion (GO:0007586)2.84463500
62barbed-end actin filament capping (GO:0051016)2.83939698
63positive regulation of insulin secretion (GO:0032024)2.83125449
64ER overload response (GO:0006983)2.81705339
65mitochondrial calcium ion transport (GO:0006851)2.76628133
66L-phenylalanine catabolic process (GO:0006559)2.75878362
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75878362
68response to misfolded protein (GO:0051788)2.75728594
69nucleoside diphosphate catabolic process (GO:0009134)2.74467598
70keratan sulfate catabolic process (GO:0042340)2.73057729
71regulation of early endosome to late endosome transport (GO:2000641)2.71962478
72pentose-phosphate shunt (GO:0006098)2.71848693
73antigen processing and presentation via MHC class Ib (GO:0002475)2.70616233
74negative regulation of myeloid cell apoptotic process (GO:0033033)2.70086168
75protein autoprocessing (GO:0016540)2.69602271
76adhesion of symbiont to host cell (GO:0044650)2.68783329
77virion attachment to host cell (GO:0019062)2.68783329
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68383665
79L-phenylalanine metabolic process (GO:0006558)2.68383665
80pteridine-containing compound biosynthetic process (GO:0042559)2.68261635
81pentose metabolic process (GO:0019321)2.66400361
82fucose metabolic process (GO:0006004)2.66374694
83cellular response to vitamin D (GO:0071305)2.66086633
84plasma lipoprotein particle assembly (GO:0034377)2.64379525
85regulation of extracellular matrix disassembly (GO:0010715)2.64331849
86glycosphingolipid catabolic process (GO:0046479)2.62679549
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62629574
88proline metabolic process (GO:0006560)2.62005749
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.62000279
90positive regulation of extracellular matrix organization (GO:1903055)2.61894688
91regulation of superoxide anion generation (GO:0032928)2.61502519
92regulation of metalloenzyme activity (GO:0048552)2.60859592
93glucose 6-phosphate metabolic process (GO:0051156)2.60389208
94Golgi organization (GO:0007030)2.59527002
95skin morphogenesis (GO:0043589)2.57718376
96oxaloacetate metabolic process (GO:0006107)2.57686806
97peptide metabolic process (GO:0006518)2.56637107
98regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56613739
99glycolipid catabolic process (GO:0019377)2.56513725
100lipopolysaccharide biosynthetic process (GO:0009103)2.55479523
101positive regulation of lipoprotein lipase activity (GO:0051006)2.54692410
102positive regulation of triglyceride lipase activity (GO:0061365)2.54692410
103regulation of cholesterol esterification (GO:0010872)2.54611809
104UV protection (GO:0009650)2.54184019
105hyaluronan catabolic process (GO:0030214)2.54054312
106* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52844902
107nucleotide salvage (GO:0043173)2.52263745
108amino sugar catabolic process (GO:0046348)2.52194838
109* nucleotide-sugar metabolic process (GO:0009225)2.51783445
110glycoside metabolic process (GO:0016137)2.51669425
111maintenance of protein localization in organelle (GO:0072595)2.51633848
112toxin metabolic process (GO:0009404)2.51461808
113NIK/NF-kappaB signaling (GO:0038061)2.50609626
114protein-lipid complex assembly (GO:0065005)2.50327956
115NADPH regeneration (GO:0006740)2.50168025
116very-low-density lipoprotein particle assembly (GO:0034379)2.49255793
117type B pancreatic cell development (GO:0003323)2.48386367
118glucose catabolic process (GO:0006007)2.46900048
119epithelial cell fate commitment (GO:0072148)2.46578971
120intra-Golgi vesicle-mediated transport (GO:0006891)2.46423769
121glandular epithelial cell development (GO:0002068)2.45536926
122protein localization to endosome (GO:0036010)2.43489961
123DNA deamination (GO:0045006)2.41896178
124endosome to pigment granule transport (GO:0043485)2.40050597
125endosome to melanosome transport (GO:0035646)2.40050597
126purine-containing compound salvage (GO:0043101)2.40038030
127ribosomal small subunit assembly (GO:0000028)2.39956163
128negative regulation of glycoprotein metabolic process (GO:1903019)2.39169851
129chaperone mediated protein folding requiring cofactor (GO:0051085)2.38764481
130negative regulation of erythrocyte differentiation (GO:0045647)2.36637397
131NADH metabolic process (GO:0006734)2.36572836
132positive regulation of triglyceride biosynthetic process (GO:0010867)2.36357455
133pyrimidine ribonucleoside catabolic process (GO:0046133)2.36023166
134negative regulation of cell size (GO:0045792)2.33882230
135beta-amyloid metabolic process (GO:0050435)2.33036961
136negative regulation of fibrinolysis (GO:0051918)2.31483650
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.30897252
138sphingolipid catabolic process (GO:0030149)2.30842356
139negative regulation of cytokine production involved in immune response (GO:0002719)2.30721811
140glutamine family amino acid biosynthetic process (GO:0009084)2.28749052
141pyrimidine nucleoside salvage (GO:0043097)2.27228565
142pyrimidine-containing compound salvage (GO:0008655)2.27228565
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.26065453
144membrane lipid catabolic process (GO:0046466)2.25932522
145nucleobase-containing small molecule interconversion (GO:0015949)2.25814687
146regulation of type I interferon-mediated signaling pathway (GO:0060338)2.25665554
147regulation of plasminogen activation (GO:0010755)2.25244571
148amyloid precursor protein catabolic process (GO:0042987)2.23867791
149endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23459402
150ceramide catabolic process (GO:0046514)2.22303117
151antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.22265896
152negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.21786050
153regulation of cytokine secretion involved in immune response (GO:0002739)2.20815585
154Arp2/3 complex-mediated actin nucleation (GO:0034314)2.18394607
155positive regulation of fatty acid biosynthetic process (GO:0045723)2.18300277
156negative regulation of viral release from host cell (GO:1902187)2.18287841
157myeloid dendritic cell differentiation (GO:0043011)2.18071018
158positive regulation of cellular amine metabolic process (GO:0033240)2.17456252
159mature B cell differentiation involved in immune response (GO:0002313)2.16387319
160* nucleotide-sugar biosynthetic process (GO:0009226)2.15936316
161regulation of cholesterol homeostasis (GO:2000188)2.14640792
162negative regulation of protein localization to plasma membrane (GO:1903077)2.14367410
163urea cycle (GO:0000050)2.13862092
164lipopolysaccharide metabolic process (GO:0008653)2.12555290
165protein hydroxylation (GO:0018126)2.11301974
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.09526313
167response to thyroid hormone (GO:0097066)2.09259606
168basement membrane organization (GO:0071711)2.08560832
169regulation of fibrinolysis (GO:0051917)2.08302591
170nucleoside diphosphate biosynthetic process (GO:0009133)2.07722290
171Golgi transport vesicle coating (GO:0048200)10.1661404
172COPI coating of Golgi vesicle (GO:0048205)10.1661404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.03589868
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.96967904
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64554821
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58728153
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49761117
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47554467
7GATA1_22025678_ChIP-Seq_K562_Human2.47534765
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.45073301
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.25335919
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23412851
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21863395
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18297535
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.16071034
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14714466
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.13069588
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07534021
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04748631
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00107238
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.97698319
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95270991
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83326058
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.79052735
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78714543
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.76957363
25ZNF263_19887448_ChIP-Seq_K562_Human1.76307087
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73376261
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73263698
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71870766
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70943926
30TFEB_21752829_ChIP-Seq_HELA_Human1.70448593
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.69805067
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.69394240
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62448599
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59823171
35LXR_22292898_ChIP-Seq_THP-1_Human1.57882190
36VDR_21846776_ChIP-Seq_THP-1_Human1.56720305
37* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56286587
38E2F7_22180533_ChIP-Seq_HELA_Human1.54650243
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54476178
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53448917
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52430280
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51246168
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51051005
44MYC_22102868_ChIP-Seq_BL_Human1.48107900
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47673983
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.46054235
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45283108
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44903848
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44498322
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42772065
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39867691
52GABP_19822575_ChIP-Seq_HepG2_Human1.39606860
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.38928780
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38672429
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38158751
56* SPI1_23547873_ChIP-Seq_NB4_Human1.37397283
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35467585
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35018094
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34772624
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33939176
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32013625
62CIITA_25753668_ChIP-Seq_RAJI_Human1.30346361
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29924222
64* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29825498
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29470686
66P68_20966046_ChIP-Seq_HELA_Human1.28642202
67MAF_26560356_Chip-Seq_TH1_Human1.27932351
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25947004
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24875127
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23734305
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23708855
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23572061
73BCOR_27268052_Chip-Seq_Bcells_Human1.23239585
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22987540
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22099987
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22071104
77NCOR1_26117541_ChIP-Seq_K562_Human1.22049484
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.21881066
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20940958
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20576670
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20544383
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20247914
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20134852
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.19259140
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18878072
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18668493
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18437097
88MAF_26560356_Chip-Seq_TH2_Human1.17752822
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17056204
90BCL6_27268052_Chip-Seq_Bcells_Human1.16708360
91VDR_23849224_ChIP-Seq_CD4+_Human1.16517566
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15477980
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.15397915
94DCP1A_22483619_ChIP-Seq_HELA_Human1.15366311
95VDR_24763502_ChIP-Seq_THP-1_Human1.15353543
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14850136
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14450745
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14145661
99* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13586492
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13561453
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.13230807
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.13123934
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12896620
104FOXP3_21729870_ChIP-Seq_TREG_Human1.12375655
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10019968
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09812948
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09580579
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09522717
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09361030
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.09046196
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08887901
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08768648
113MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08548342
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08044259
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07796422
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07716426
117CLOCK_20551151_ChIP-Seq_293T_Human1.07624315
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06510785
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05969316
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05960465
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05618261
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05311743
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03886305
124XRN2_22483619_ChIP-Seq_HELA_Human1.03742899
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03644868
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03551292
127TCF7_22412390_ChIP-Seq_EML_Mouse1.03531224
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03205664
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03062893
130* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02912362
131UTX_26944678_Chip-Seq_JUKART_Human1.02466039
132CTCF_26484167_Chip-Seq_Bcells_Mouse1.02060632
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01318226
134ATF3_27146783_Chip-Seq_COLON_Human1.00766712
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00718409
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00632407
137SCL_19346495_ChIP-Seq_HPC-7_Human0.99819874
138IRF8_21731497_ChIP-ChIP_J774_Mouse0.99692957
139RACK7_27058665_Chip-Seq_MCF-7_Human0.99200419
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99099155
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98450952
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97704558
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97189146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005220_abnormal_exocrine_pancreas3.37266733
2MP0005451_abnormal_body_composition3.29880421
3MP0002877_abnormal_melanocyte_morpholog3.15500750
4MP0001666_abnormal_nutrient_absorption3.09180075
5MP0002693_abnormal_pancreas_physiology3.05869469
6MP0003183_abnormal_peptide_metabolism2.98588832
7MP0005365_abnormal_bile_salt2.84800599
8MP0003195_calcinosis2.80599153
9MP0001944_abnormal_pancreas_morphology2.69882852
10MP0005058_abnormal_lysosome_morphology2.61892499
11MP0000013_abnormal_adipose_tissue2.56084103
12MP0003283_abnormal_digestive_organ2.53698885
13MP0004043_abnormal_pH_regulation2.45074248
14MP0005083_abnormal_biliary_tract2.43015132
15MP0002909_abnormal_adrenal_gland2.31228805
16MP0004264_abnormal_extraembryonic_tissu2.26607984
17MP0006054_spinal_hemorrhage2.22487961
18MP0002139_abnormal_hepatobiliary_system2.16592418
19MP0010386_abnormal_urinary_bladder2.15137406
20MP0009780_abnormal_chondrocyte_physiolo2.12907053
21MP0008260_abnormal_autophagy2.08531164
22MP0000678_abnormal_parathyroid_gland1.98821194
23MP0003172_abnormal_lysosome_physiology1.94932671
24MP0009840_abnormal_foam_cell1.90347415
25MP0003806_abnormal_nucleotide_metabolis1.89220572
26MP0009643_abnormal_urine_homeostasis1.83384743
27MP0003868_abnormal_feces_composition1.81844701
28MP0000003_abnormal_adipose_tissue1.79795463
29MP0002837_dystrophic_cardiac_calcinosis1.78063707
30MP0003300_gastrointestinal_ulcer1.68132000
31MP0002078_abnormal_glucose_homeostasis1.66993068
32MP0003436_decreased_susceptibility_to1.66465517
33MP0003866_abnormal_defecation1.59786916
34MP0003279_aneurysm1.57935053
35MP0005464_abnormal_platelet_physiology1.51467770
36MP0001835_abnormal_antigen_presentation1.50193030
37MP0003191_abnormal_cellular_cholesterol1.48312955
38MP0005084_abnormal_gallbladder_morpholo1.44832020
39MP0000685_abnormal_immune_system1.43740106
40MP0008438_abnormal_cutaneous_collagen1.41469575
41MP0004272_abnormal_basement_membrane1.38103132
42MP0003959_abnormal_lean_body1.36820769
43MP0005085_abnormal_gallbladder_physiolo1.36381810
44MP0003186_abnormal_redox_activity1.36117484
45MP0003252_abnormal_bile_duct1.35341643
46MP0009785_altered_susceptibility_to1.30301982
47MP0003303_peritoneal_inflammation1.29456943
48MP0001853_heart_inflammation1.26608006
49MP0001533_abnormal_skeleton_physiology1.26282490
50MP0005379_endocrine/exocrine_gland_phen1.24321663
51MP0003075_altered_response_to1.23404221
52MP0005636_abnormal_mineral_homeostasis1.23017014
53MP0005671_abnormal_response_to1.22464117
54MP0001873_stomach_inflammation1.21101883
55MP0001845_abnormal_inflammatory_respons1.20160319
56MP0000490_abnormal_crypts_of1.15920810
57MP0005319_abnormal_enzyme/_coenzyme1.14407496
58MP0000613_abnormal_salivary_gland1.14366185
59MP0002060_abnormal_skin_morphology1.14202283
60MP0002118_abnormal_lipid_homeostasis1.14186551
61MP0001756_abnormal_urination1.13497218
62MP0003950_abnormal_plasma_membrane1.13212000
63MP0000609_abnormal_liver_physiology1.12905073
64MP0004858_abnormal_nervous_system1.11746121
65MP0005332_abnormal_amino_acid1.11119369
66MP0005025_abnormal_response_to1.10893999
67MP0001849_ear_inflammation1.10832030
68MP0001765_abnormal_ion_homeostasis1.10182033
69MP0009384_cardiac_valve_regurgitation1.10123386
70MP0005000_abnormal_immune_tolerance1.08245191
71MP0001958_emphysema1.08191974
72MP0002933_joint_inflammation1.07428127
73MP0008469_abnormal_protein_level1.06466687
74MP0001790_abnormal_immune_system1.06123527
75MP0005387_immune_system_phenotype1.06123527
76MP0003448_altered_tumor_morphology1.05469947
77MP0001661_extended_life_span1.05361941
78MP0005165_increased_susceptibility_to1.04458209
79MP0006036_abnormal_mitochondrial_physio1.04456348
80MP0009333_abnormal_splenocyte_physiolog1.03524280
81MP0003453_abnormal_keratinocyte_physiol1.03303852
82MP0002419_abnormal_innate_immunity1.02780497
83MP0002148_abnormal_hypersensitivity_rea1.01295177
84MP0003705_abnormal_hypodermis_morpholog1.01055969
85MP0004510_myositis0.98967599
86MP0002896_abnormal_bone_mineralization0.98668095
87MP0001542_abnormal_bone_strength0.96790873
88MP0005408_hypopigmentation0.96511663
89MP0000343_altered_response_to0.96337664
90MP0010155_abnormal_intestine_physiology0.95776655
91MP0003693_abnormal_embryo_hatching0.95442243
92MP0003724_increased_susceptibility_to0.94730000
93MP0005375_adipose_tissue_phenotype0.93304127
94MP0010329_abnormal_lipoprotein_level0.93262281
95MP0003953_abnormal_hormone_level0.91361677
96MP0005310_abnormal_salivary_gland0.91326724
97MP0001800_abnormal_humoral_immune0.90945582
98MP0001764_abnormal_homeostasis0.90607610
99MP0003795_abnormal_bone_structure0.90239209
100MP0000604_amyloidosis0.89399287
101MP0009278_abnormal_bone_marrow0.89196174
102MP0001243_abnormal_dermal_layer0.88244661
103MP0005360_urolithiasis0.87974475
104MP0002723_abnormal_immune_serum0.87953802
105MP0005275_abnormal_skin_tensile0.87535938
106MP0001664_abnormal_digestion0.86523661
107MP0009642_abnormal_blood_homeostasis0.86458874
108MP0003566_abnormal_cell_adhesion0.86031268
109MP0002089_abnormal_postnatal_growth/wei0.84807594
110MP0003763_abnormal_thymus_physiology0.84565569
111MP0004947_skin_inflammation0.84174100
112MP0004233_abnormal_muscle_weight0.84160250
113MP0001881_abnormal_mammary_gland0.83947216
114MP0005390_skeleton_phenotype0.83917744
115MP0005503_abnormal_tendon_morphology0.82685193
116MP0005076_abnormal_cell_differentiation0.82533131
117MP0000767_abnormal_smooth_muscle0.82008019
118MP0005257_abnormal_intraocular_pressure0.81861620
119MP0000598_abnormal_liver_morphology0.81604484
120MP0002254_reproductive_system_inflammat0.81581144
121MP0006082_CNS_inflammation0.80938606
122MP0003786_premature_aging0.79566290
123MP0002429_abnormal_blood_cell0.79382479
124MP0002138_abnormal_hepatobiliary_system0.78967170
125MP0010234_abnormal_vibrissa_follicle0.78360998
126MP0008875_abnormal_xenobiotic_pharmacok0.78270472
127MP0002405_respiratory_system_inflammati0.78211952
128MP0000858_altered_metastatic_potential0.78178253
129MP0005330_cardiomyopathy0.77653739
130MP0005023_abnormal_wound_healing0.77548705
131MP0002998_abnormal_bone_remodeling0.77464027
132MP0002452_abnormal_antigen_presenting0.76705308
133MP0005166_decreased_susceptibility_to0.76669763
134MP0001986_abnormal_taste_sensitivity0.76614842
135MP0003091_abnormal_cell_migration0.75857779
136MP0002420_abnormal_adaptive_immunity0.75813962
137MP0005164_abnormal_response_to0.75787244
138MP0003111_abnormal_nucleus_morphology0.75767579
139MP0001819_abnormal_immune_cell0.74768530
140MP0002398_abnormal_bone_marrow0.74602087
141MP0002269_muscular_atrophy0.74297503
142MP0003656_abnormal_erythrocyte_physiolo0.74162837
143MP0002166_altered_tumor_susceptibility0.73856980
144MP0000681_abnormal_thyroid_gland0.71971696
145MP0000358_abnormal_cell_content/0.71955859

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.08545063
2Hyperinsulinemic hypoglycemia (HP:0000825)4.67666978
3Hypoglycemic seizures (HP:0002173)4.64047632
4Symptomatic seizures (HP:0011145)4.41306216
5Premature rupture of membranes (HP:0001788)4.28834769
6Vacuolated lymphocytes (HP:0001922)3.97225590
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.79354158
8Ketoacidosis (HP:0001993)3.78455334
9Generalized aminoaciduria (HP:0002909)3.76427808
10Dysostosis multiplex (HP:0000943)3.74568318
11Late onset (HP:0003584)3.64579917
12Protrusio acetabuli (HP:0003179)3.64170081
13Urinary glycosaminoglycan excretion (HP:0003541)3.59868612
14Mucopolysacchariduria (HP:0008155)3.59868612
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.47302423
16Abnormal protein N-linked glycosylation (HP:0012347)3.47302423
17Abnormal protein glycosylation (HP:0012346)3.47302423
18Abnormal glycosylation (HP:0012345)3.47302423
19Abnormality of the pancreatic islet cells (HP:0006476)3.40223585
20Abnormality of endocrine pancreas physiology (HP:0012093)3.40223585
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.35744193
22Abnormality of polysaccharide metabolism (HP:0011012)3.35744193
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.35744193
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32351265
25Systemic lupus erythematosus (HP:0002725)3.31833056
26Insulin-resistant diabetes mellitus (HP:0000831)3.28459841
27Abnormality of the intrinsic pathway (HP:0010989)3.27434796
28Ketosis (HP:0001946)3.25831388
29Abnormal gallbladder physiology (HP:0012438)3.25555264
30Cholecystitis (HP:0001082)3.25555264
31Type I transferrin isoform profile (HP:0003642)3.09798406
32Hyperglycemia (HP:0003074)3.06690477
33Large for gestational age (HP:0001520)3.06264080
34Deep venous thrombosis (HP:0002625)3.04345576
35Insulin resistance (HP:0000855)2.72528563
36Achilles tendon contracture (HP:0001771)2.71045441
37Abnormality of the Achilles tendon (HP:0005109)2.69722234
38Abnormality of glycolipid metabolism (HP:0010969)2.68862366
39Abnormality of liposaccharide metabolism (HP:0010968)2.68862366
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.68862366
41Abdominal distention (HP:0003270)2.68766242
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.61512725
43Pancreatic islet-cell hyperplasia (HP:0004510)2.60272753
44Increased cerebral lipofuscin (HP:0011813)2.59099648
45J-shaped sella turcica (HP:0002680)2.56523913
46Abnormality of macrophages (HP:0004311)2.55986672
47Abnormality of calcium-phosphate metabolism (HP:0100530)2.50975019
48Prolonged neonatal jaundice (HP:0006579)2.50757925
49Purpura (HP:0000979)2.49252292
50Protuberant abdomen (HP:0001538)2.48039308
51Biconcave vertebral bodies (HP:0004586)2.47046760
52Beaking of vertebral bodies (HP:0004568)2.45082094
53Dicarboxylic aciduria (HP:0003215)2.43429494
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43429494
55Increased serum ferritin (HP:0003281)2.41308941
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39705371
57Cervical subluxation (HP:0003308)2.38158679
58Aplastic anemia (HP:0001915)2.37188855
59Thrombocytosis (HP:0001894)2.34678126
60Hyperparathyroidism (HP:0000843)2.34449571
61Gout (HP:0001997)2.32618041
62Nonimmune hydrops fetalis (HP:0001790)2.32587158
63Abnormality of complement system (HP:0005339)2.30743728
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29419161
65Progressive muscle weakness (HP:0003323)2.26729379
66Joint stiffness (HP:0001387)2.26503541
67Fragile skin (HP:0001030)2.26427917
68Abnormality of the common coagulation pathway (HP:0010990)2.23471812
69Blue sclerae (HP:0000592)2.20547800
70Hemorrhage of the eye (HP:0011885)2.20419603
71Upper limb amyotrophy (HP:0009129)2.19413016
72Distal upper limb amyotrophy (HP:0007149)2.19413016
73Vertebral compression fractures (HP:0002953)2.18378346
74Reduced antithrombin III activity (HP:0001976)2.15544366
75Abnormal pancreas size (HP:0012094)2.14899904
76Xanthomatosis (HP:0000991)2.14791473
77Hypertensive crisis (HP:0100735)2.14421983
78Hepatic necrosis (HP:0002605)2.14094592
79Rough bone trabeculation (HP:0100670)2.13928703
80Progressive neurologic deterioration (HP:0002344)2.13511471
81Myoglobinuria (HP:0002913)2.12499037
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12047461
83Loss of speech (HP:0002371)2.11544080
84Broad face (HP:0000283)2.08687049
85Complement deficiency (HP:0004431)2.08447084
86Myocardial infarction (HP:0001658)2.07248085
87Spondylolisthesis (HP:0003302)2.05963573
88Exocrine pancreatic insufficiency (HP:0001738)2.05163522
89Stridor (HP:0010307)2.04365065
90Retinal atrophy (HP:0001105)2.03140246
91Glomerulonephritis (HP:0000099)2.02777379
92Growth hormone excess (HP:0000845)2.01665631
93Petechiae (HP:0000967)2.00490164
94Elbow flexion contracture (HP:0002987)2.00343219
95Conjugated hyperbilirubinemia (HP:0002908)1.99956438
96Abnormality of T cell physiology (HP:0011840)1.99937364
97Distal lower limb muscle weakness (HP:0009053)1.98529269
98Abnormality of fatty-acid metabolism (HP:0004359)1.97006407
99Axonal loss (HP:0003447)1.95021416
100Opisthotonus (HP:0002179)1.94233901
101Dilatation of the ascending aorta (HP:0005111)1.93223327
102Cortical visual impairment (HP:0100704)1.93019640
103Agitation (HP:0000713)1.92337944
104Hepatosplenomegaly (HP:0001433)1.91553927
105IgM deficiency (HP:0002850)1.91510119
106Malnutrition (HP:0004395)1.89540033
107Ankle contracture (HP:0006466)1.89532681
108Interstitial pulmonary disease (HP:0006530)1.88557390
109Pancreatitis (HP:0001733)1.87590222
110Obstructive lung disease (HP:0006536)1.87489809
111Chronic obstructive pulmonary disease (HP:0006510)1.87489809
112Ragged-red muscle fibers (HP:0003200)1.87446653
113Mitral stenosis (HP:0001718)1.85997437
114Orchitis (HP:0100796)1.85849791
115Abnormality of carpal bone ossification (HP:0006257)1.85849044
116Abnormality of purine metabolism (HP:0004352)1.85838619
117Emphysema (HP:0002097)1.85276834
118Atrophic scars (HP:0001075)1.83963012
119Poor head control (HP:0002421)1.83425268
120Bladder diverticulum (HP:0000015)1.83181828
121Abnormality of the acetabulum (HP:0003170)1.82724353
122Cardiovascular calcification (HP:0011915)1.82217694
123Thin bony cortex (HP:0002753)1.82005765
124Reticulocytosis (HP:0001923)1.81974809
125Entropion (HP:0000621)1.80458354
126Abnormality of dentin (HP:0010299)1.78848715
127Myositis (HP:0100614)1.78547718
128Hand muscle atrophy (HP:0009130)1.78512706
129Hypokinesia (HP:0002375)1.78193778
130Flat acetabular roof (HP:0003180)1.78112051
131Methylmalonic aciduria (HP:0012120)1.76414707
132Increased connective tissue (HP:0009025)1.76373823
133Thoracolumbar scoliosis (HP:0002944)1.76001633
134Cholelithiasis (HP:0001081)1.75184722
135Hypokalemia (HP:0002900)1.74745702
136Amyloidosis (HP:0011034)1.73747688
137Elevated alkaline phosphatase (HP:0003155)1.73432294
138Abnormality of alkaline phosphatase activity (HP:0004379)1.72546490
139Generalized amyotrophy (HP:0003700)1.72287396
140Abnormal trabecular bone morphology (HP:0100671)1.72283931
141Abnormality of the costochondral junction (HP:0000919)1.71812653
142Vascular calcification (HP:0004934)1.71584147
143Peritonitis (HP:0002586)1.71398157
144Hypertriglyceridemia (HP:0002155)1.71109865
145Abnormality of subcutaneous fat tissue (HP:0001001)1.71010372
146Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70911360
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70911360
148Trismus (HP:0000211)1.70904855
149Prominent metopic ridge (HP:0005487)1.69586819
150Asymmetric septal hypertrophy (HP:0001670)1.69014401
151Decreased subcutaneous fat (HP:0001002)1.68858559
152Fat malabsorption (HP:0002630)1.68762410
153Abnormal enzyme/coenzyme activity (HP:0012379)1.68104308
154Palpitations (HP:0001962)1.67858767
155Skin nodule (HP:0200036)1.67143855
156Abnormal delivery (HP:0001787)1.66898281
157Abnormality of iron homeostasis (HP:0011031)1.65882170
158Irregular vertebral endplates (HP:0003301)1.65644536
159Abnormality of the anterior horn cell (HP:0006802)1.65505535
160Degeneration of anterior horn cells (HP:0002398)1.65505535
161Severe short stature (HP:0003510)1.65468006
162Joint hemorrhage (HP:0005261)1.65245389
163Myopathic facies (HP:0002058)1.65238137
164Abnormal tarsal ossification (HP:0008369)1.65182559
165Glucose intolerance (HP:0000833)1.65025221
166Cerebral aneurysm (HP:0004944)1.64752929
167Nuclear cataract (HP:0100018)1.63894692
168Wormian bones (HP:0002645)1.62517573
169Premature skin wrinkling (HP:0100678)1.61941906
170Aortic dissection (HP:0002647)1.61389964
171Polygenic inheritance (HP:0010982)1.60205181
172Short nail (HP:0001799)1.60183718
173Recurrent abscess formation (HP:0002722)1.59749360
174Spinal rigidity (HP:0003306)1.57017037
175Upper motor neuron abnormality (HP:0002127)1.56840111
176Distal lower limb amyotrophy (HP:0008944)1.55750587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.22856178
2BCKDK4.34376201
3FLT33.63950865
4INSRR3.35669870
5PASK2.96436527
6TRIB32.81130596
7TAOK32.68907410
8NME22.57936121
9MAPK152.53530240
10SMG12.52080947
11SCYL22.40923707
12IRAK32.38179614
13PIK3CG2.23246149
14TESK12.05197116
15MAP3K112.00743169
16ICK1.93432950
17PKN21.86141923
18EIF2AK31.83384839
19MAP2K21.70440492
20ZAP701.63807726
21MAPKAPK31.62684593
22JAK31.57815129
23TAOK21.56276079
24CAMKK21.49051360
25HIPK21.42468037
26MAP4K11.42102134
27PRPF4B1.40638766
28IRAK41.40450983
29PIM21.40298233
30TBK11.38322846
31DDR21.31584505
32STK161.31138103
33TYK21.24438999
34KIT1.24366247
35RIPK41.21688577
36PTK61.20405671
37TESK21.19301829
38MAP3K11.16409923
39SIK11.16185112
40MET1.14791046
41FRK1.12182386
42BTK1.10189285
43VRK21.09086629
44MAPK111.06803272
45ABL21.06269912
46MAP2K31.05064723
47EIF2AK11.03814245
48BUB11.03178872
49MAP3K21.02351882
50NME11.01651240
51MAP3K80.98752357
52WNK40.98207019
53FGFR40.97865687
54MAP3K120.95858927
55EEF2K0.95530965
56ARAF0.94487624
57NEK90.91069346
58CLK10.89630304
59MYLK0.87293064
60PTK20.86391885
61RPS6KB20.85315882
62DAPK10.77950611
63BMX0.77723098
64JAK10.77520513
65PRKD20.77396368
66PDGFRA0.77380415
67EPHB10.76583665
68IRAK10.76569920
69LRRK20.76521855
70PBK0.75116234
71DYRK1B0.73634942
72PRKD30.73608074
73BRAF0.71994151
74LMTK20.70659129
75MAP3K30.70462278
76KDR0.69538996
77EPHA20.68336379
78GRK60.68173458
79IKBKE0.66503881
80BRSK20.66144733
81EPHA30.66056191
82NTRK10.65559375
83TTN0.62980892
84RIPK10.62845167
85RPS6KA40.62447849
86CDK70.61377531
87PAK10.60475095
88PRKCI0.59654071
89PDPK10.59436303
90MAP3K130.59263182
91JAK20.58825670
92TEC0.58480023
93MATK0.54890130
94SYK0.54102956
95PAK40.52793175
96BRSK10.52541289
97MST1R0.51659043
98SIK30.50559368
99BLK0.49199802
100CSK0.49189830
101STK100.48106574
102PAK20.47962908
103AURKA0.46980239
104NLK0.45822532
105CSF1R0.44551364
106LYN0.43103144
107PRKCH0.42610504
108MAP2K10.42493210
109IKBKB0.42427295
110CDK40.40679513
111UHMK10.39609711
112PRKG20.39235522
113STK40.39207071
114TNK20.38668322
115ITK0.38527536
116LCK0.37962153
117MOS0.36942431
118CDC42BPA0.36919757
119PIK3CA0.35439134
120DAPK30.35068977
121LIMK10.34974263
122CHUK0.33767994
123MST40.33625197
124TGFBR10.32976941
125CDK80.31759250
126MAP3K60.31289285
127TGFBR20.31125132
128MAPKAPK20.31022125
129RPS6KA20.30477107
130TAOK10.30178456
131ILK0.29818439
132MAP3K140.29488970
133MTOR0.28497253
134PRKCD0.28437075
135ERBB30.27407630
136PDGFRB0.27240579
137MAP2K60.25605200
138KSR20.25425194
139PAK30.24544799

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.57778085
2Protein export_Homo sapiens_hsa030606.30289763
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.63406756
4Sulfur metabolism_Homo sapiens_hsa009203.36846277
5N-Glycan biosynthesis_Homo sapiens_hsa005102.94214902
6Other glycan degradation_Homo sapiens_hsa005112.66699566
7Folate biosynthesis_Homo sapiens_hsa007902.40069781
8* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.09096689
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06435855
10Lysosome_Homo sapiens_hsa041422.01686003
11Vibrio cholerae infection_Homo sapiens_hsa051101.96851544
12Selenocompound metabolism_Homo sapiens_hsa004501.87563376
13Fat digestion and absorption_Homo sapiens_hsa049751.83895123
14Galactose metabolism_Homo sapiens_hsa000521.77108303
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.73297916
16Complement and coagulation cascades_Homo sapiens_hsa046101.69581606
17Pancreatic secretion_Homo sapiens_hsa049721.65101000
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61537895
19Glutathione metabolism_Homo sapiens_hsa004801.39623985
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37927340
21Legionellosis_Homo sapiens_hsa051341.29277804
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27237325
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25619741
24Sulfur relay system_Homo sapiens_hsa041221.24831232
25Protein digestion and absorption_Homo sapiens_hsa049741.23248625
26Arginine biosynthesis_Homo sapiens_hsa002201.22088109
27DNA replication_Homo sapiens_hsa030301.20458162
28Fatty acid degradation_Homo sapiens_hsa000711.15355433
29Shigellosis_Homo sapiens_hsa051311.11064472
30Insulin secretion_Homo sapiens_hsa049111.09768037
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.09652619
32Primary immunodeficiency_Homo sapiens_hsa053401.06095265
33Antigen processing and presentation_Homo sapiens_hsa046121.05643791
34Starch and sucrose metabolism_Homo sapiens_hsa005001.01875546
35Ribosome_Homo sapiens_hsa030100.98819415
36Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98731077
37ABC transporters_Homo sapiens_hsa020100.91997686
38Base excision repair_Homo sapiens_hsa034100.89840170
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89727810
40Tryptophan metabolism_Homo sapiens_hsa003800.89421198
41Salmonella infection_Homo sapiens_hsa051320.88736389
42Type I diabetes mellitus_Homo sapiens_hsa049400.87193813
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.81879181
44Peroxisome_Homo sapiens_hsa041460.81055450
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80343077
46Allograft rejection_Homo sapiens_hsa053300.77895662
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77747517
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75892644
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.74692796
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74018361
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71070122
52Regulation of autophagy_Homo sapiens_hsa041400.71036220
53Malaria_Homo sapiens_hsa051440.70922049
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70842416
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70444865
56Type II diabetes mellitus_Homo sapiens_hsa049300.70312229
57Insulin resistance_Homo sapiens_hsa049310.70287819
58Oxidative phosphorylation_Homo sapiens_hsa001900.70232967
59Osteoclast differentiation_Homo sapiens_hsa043800.69963875
60Pentose phosphate pathway_Homo sapiens_hsa000300.68527313
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67778589
62Graft-versus-host disease_Homo sapiens_hsa053320.67075845
63Chronic myeloid leukemia_Homo sapiens_hsa052200.66376132
64Autoimmune thyroid disease_Homo sapiens_hsa053200.65599815
65Prion diseases_Homo sapiens_hsa050200.64825987
66Leishmaniasis_Homo sapiens_hsa051400.63959711
67TNF signaling pathway_Homo sapiens_hsa046680.63380228
68PPAR signaling pathway_Homo sapiens_hsa033200.62922057
69Carbon metabolism_Homo sapiens_hsa012000.62474988
70Renin-angiotensin system_Homo sapiens_hsa046140.62022988
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60496617
72Phenylalanine metabolism_Homo sapiens_hsa003600.60269881
73Propanoate metabolism_Homo sapiens_hsa006400.58942566
74Proteasome_Homo sapiens_hsa030500.57924305
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56364613
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56190094
77Epstein-Barr virus infection_Homo sapiens_hsa051690.56182819
78Measles_Homo sapiens_hsa051620.56085300
79Histidine metabolism_Homo sapiens_hsa003400.56054656
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55854694
81Arginine and proline metabolism_Homo sapiens_hsa003300.55624220
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55011209
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54501720
84Phagosome_Homo sapiens_hsa041450.54271285
85Biosynthesis of amino acids_Homo sapiens_hsa012300.54141544
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53565713
87Hepatitis C_Homo sapiens_hsa051600.53544892
88Herpes simplex infection_Homo sapiens_hsa051680.52181206
89Vitamin digestion and absorption_Homo sapiens_hsa049770.51995664
90Linoleic acid metabolism_Homo sapiens_hsa005910.50932046
91Pertussis_Homo sapiens_hsa051330.50706622
92Amoebiasis_Homo sapiens_hsa051460.49362418
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49117391
94Toxoplasmosis_Homo sapiens_hsa051450.48955059
95VEGF signaling pathway_Homo sapiens_hsa043700.48361094
96* Metabolic pathways_Homo sapiens_hsa011000.47161379
97Hematopoietic cell lineage_Homo sapiens_hsa046400.45494650
98* Fructose and mannose metabolism_Homo sapiens_hsa000510.44927790
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43728372
100Pyruvate metabolism_Homo sapiens_hsa006200.43414188
101Viral carcinogenesis_Homo sapiens_hsa052030.43376900
102Hepatitis B_Homo sapiens_hsa051610.42865933
103Pyrimidine metabolism_Homo sapiens_hsa002400.42179351
104Viral myocarditis_Homo sapiens_hsa054160.41630900
105Sphingolipid metabolism_Homo sapiens_hsa006000.41037522
106Fatty acid metabolism_Homo sapiens_hsa012120.40738029
107Non-small cell lung cancer_Homo sapiens_hsa052230.39798494
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38514449
109Asthma_Homo sapiens_hsa053100.38347257
110Mineral absorption_Homo sapiens_hsa049780.38188667
111Thyroid hormone synthesis_Homo sapiens_hsa049180.38080814
112Bladder cancer_Homo sapiens_hsa052190.37951767
113Parkinsons disease_Homo sapiens_hsa050120.37376737
114Endocytosis_Homo sapiens_hsa041440.36966161
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35146442
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.34641257
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34139378
118Collecting duct acid secretion_Homo sapiens_hsa049660.32564490
119Caffeine metabolism_Homo sapiens_hsa002320.32243085
120Alzheimers disease_Homo sapiens_hsa050100.31427678
121Glycerolipid metabolism_Homo sapiens_hsa005610.29423233
122Arachidonic acid metabolism_Homo sapiens_hsa005900.29049564
123Tuberculosis_Homo sapiens_hsa051520.27663209
124Prolactin signaling pathway_Homo sapiens_hsa049170.27419673
125One carbon pool by folate_Homo sapiens_hsa006700.27177951
126Tyrosine metabolism_Homo sapiens_hsa003500.26735975
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26362177
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.26355608
129Rheumatoid arthritis_Homo sapiens_hsa053230.25966691
130Influenza A_Homo sapiens_hsa051640.25904247
131Apoptosis_Homo sapiens_hsa042100.25459297
132Fatty acid elongation_Homo sapiens_hsa000620.24233882
133Staphylococcus aureus infection_Homo sapiens_hsa051500.24226503
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22688227
135Butanoate metabolism_Homo sapiens_hsa006500.18298983
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.18008731
137Acute myeloid leukemia_Homo sapiens_hsa052210.17938142

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