GMPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)7.61984430
2oxygen transport (GO:0015671)7.07334775
3protoporphyrinogen IX biosynthetic process (GO:0006782)6.75703893
4porphyrin-containing compound biosynthetic process (GO:0006779)6.43037260
5gas transport (GO:0015669)6.26410251
6tetrapyrrole biosynthetic process (GO:0033014)5.84885855
7heme biosynthetic process (GO:0006783)5.57272066
8skeletal muscle contraction (GO:0003009)5.36165119
9tricarboxylic acid cycle (GO:0006099)5.30668302
10sarcomere organization (GO:0045214)5.20089576
11hemoglobin metabolic process (GO:0020027)5.19605364
12creatine metabolic process (GO:0006600)5.10336700
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.99362398
14muscle filament sliding (GO:0030049)4.91082902
15actin-myosin filament sliding (GO:0033275)4.91082902
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.83587678
17porphyrin-containing compound metabolic process (GO:0006778)4.75742288
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.69204353
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.67267854
20sarcoplasmic reticulum calcium ion transport (GO:0070296)4.67266902
21negative regulation of erythrocyte differentiation (GO:0045647)4.64015256
22cardiac myofibril assembly (GO:0055003)4.58183923
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.56641393
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.51881159
25actin filament-based movement (GO:0030048)4.50270963
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.48172120
27regulation of platelet aggregation (GO:0090330)4.46696141
28respiratory electron transport chain (GO:0022904)4.36265388
29cardiac muscle contraction (GO:0060048)4.35216127
30myofibril assembly (GO:0030239)4.35124800
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.34859267
32NADH metabolic process (GO:0006734)4.29809928
33oxidative phosphorylation (GO:0006119)4.29661346
34ATP synthesis coupled proton transport (GO:0015986)4.27246879
35energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27246879
36electron transport chain (GO:0022900)4.26883716
37heart contraction (GO:0060047)4.19007663
38heart process (GO:0003015)4.19007663
39heme metabolic process (GO:0042168)4.11366230
40regulation of acyl-CoA biosynthetic process (GO:0050812)4.01255888
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.00242967
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.98252433
43regulation of skeletal muscle contraction (GO:0014819)3.94072793
44neutrophil activation involved in immune response (GO:0002283)3.93155459
45actin-mediated cell contraction (GO:0070252)3.90420842
46myeloid cell development (GO:0061515)3.90363332
47regulation of oxidative phosphorylation (GO:0002082)3.85966087
48cell communication by electrical coupling (GO:0010644)3.85135946
49negative regulation of potassium ion transmembrane transport (GO:1901380)3.83819701
50protein maturation by protein folding (GO:0022417)3.80159019
51regulation of cofactor metabolic process (GO:0051193)3.75993760
52regulation of coenzyme metabolic process (GO:0051196)3.75993760
53response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.75627336
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.74879406
55cellular response to thyroid hormone stimulus (GO:0097067)3.73658473
56skeletal muscle adaptation (GO:0043501)3.70191884
57regulation of relaxation of muscle (GO:1901077)3.68602487
58detection of calcium ion (GO:0005513)3.65334179
59plasma membrane repair (GO:0001778)3.65278303
60regulation of actin filament-based movement (GO:1903115)3.63438414
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.62879094
62striated muscle contraction (GO:0006941)3.60314403
63calcium-mediated signaling using intracellular calcium source (GO:0035584)3.55135385
64succinate metabolic process (GO:0006105)3.54934558
65regulation of cell communication by electrical coupling (GO:0010649)3.54214983
66negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.52232525
67negative regulation of necroptotic process (GO:0060546)3.51585844
68regulation of the force of heart contraction (GO:0002026)3.50021358
69carnitine shuttle (GO:0006853)3.44009202
70negative regulation of calcium ion transmembrane transport (GO:1903170)3.42647591
71negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.42647591
72response to insecticide (GO:0017085)3.40451407
73negative regulation of muscle hypertrophy (GO:0014741)3.39960378
74regulation of response to osmotic stress (GO:0047484)3.33788326
75receptor recycling (GO:0001881)3.31884916
76skeletal muscle tissue regeneration (GO:0043403)3.30216194
77cardiac muscle tissue morphogenesis (GO:0055008)3.29914449
78positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.28316474
79melanin biosynthetic process (GO:0042438)3.28260046
80activation of protein kinase A activity (GO:0034199)3.28115806
81negative regulation of cardiac muscle hypertrophy (GO:0010614)3.27674947
82muscle contraction (GO:0006936)3.27448291
83ATP biosynthetic process (GO:0006754)3.27386059
84ubiquinone biosynthetic process (GO:0006744)3.24932050
85quinone biosynthetic process (GO:1901663)3.24932050
86regulation of striated muscle contraction (GO:0006942)3.24885919
87negative regulation of norepinephrine secretion (GO:0010700)3.24117474
88cell communication involved in cardiac conduction (GO:0086065)3.23068631
89oxaloacetate metabolic process (GO:0006107)3.22674469
90definitive hemopoiesis (GO:0060216)3.22357951
91response to inactivity (GO:0014854)3.22037005
92negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22013633
93erythrocyte maturation (GO:0043249)3.21727492
94positive regulation of granulocyte differentiation (GO:0030854)3.20220645
95regulation of calcium ion transmembrane transport (GO:1903169)3.18086274
96regulation of calcium ion transmembrane transporter activity (GO:1901019)3.18086274
97actomyosin structure organization (GO:0031032)3.17668319
98regulation of membrane repolarization (GO:0060306)3.17661994
993-UTR-mediated mRNA stabilization (GO:0070935)3.16104790
100platelet formation (GO:0030220)3.15987926
101cardiac muscle cell development (GO:0055013)3.15088235
102tetrapyrrole metabolic process (GO:0033013)3.14296852
103regulation of necroptotic process (GO:0060544)3.13614318
104erythrocyte development (GO:0048821)3.11300576
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.10887353
106skeletal muscle fiber development (GO:0048741)3.07185521
107tricarboxylic acid metabolic process (GO:0072350)3.05529958
108megakaryocyte development (GO:0035855)3.04342494
109response to muscle activity (GO:0014850)3.02007731
110muscle system process (GO:0003012)3.01826503
111adrenergic receptor signaling pathway (GO:0071875)3.01239169
112relaxation of cardiac muscle (GO:0055119)3.00597257
113pyrimidine ribonucleoside catabolic process (GO:0046133)3.00515175
114regulation of platelet activation (GO:0010543)3.00367359
115melanin metabolic process (GO:0006582)2.99871934
116COPI coating of Golgi vesicle (GO:0048205)2.97682019
117Golgi transport vesicle coating (GO:0048200)2.97682019
118muscle tissue morphogenesis (GO:0060415)2.93000674
119purine nucleotide salvage (GO:0032261)2.91899194
120granulocyte differentiation (GO:0030851)2.91890413
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91256403
122glycogen catabolic process (GO:0005980)2.91105617
123cytidine deamination (GO:0009972)2.90094661
124cytidine metabolic process (GO:0046087)2.90094661
125cytidine catabolic process (GO:0006216)2.90094661
126heart trabecula formation (GO:0060347)2.89777402
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.88291384
128myotube cell development (GO:0014904)2.86545325
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.84580038
130cardiac cell development (GO:0055006)2.83105333
131regulation of erythrocyte differentiation (GO:0045646)2.82180851
132regulation of sulfur metabolic process (GO:0042762)2.80816704
133regulation of integrin-mediated signaling pathway (GO:2001044)2.80208904
134ubiquinone metabolic process (GO:0006743)2.80145393
135cardiac muscle hypertrophy (GO:0003300)2.80122197
136CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79210741
137neuronal action potential propagation (GO:0019227)2.79076205
138glucan catabolic process (GO:0009251)2.78893305
139inner mitochondrial membrane organization (GO:0007007)2.78825943
140striated muscle atrophy (GO:0014891)2.76444839
141glycogen biosynthetic process (GO:0005978)2.75640411
142glucan biosynthetic process (GO:0009250)2.75640411
143negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.74769440
144response to thyroid hormone (GO:0097066)2.74335004
145positive regulation of gamma-delta T cell activation (GO:0046645)2.72176634
146positive regulation of myotube differentiation (GO:0010831)2.72154384
147negative regulation of muscle contraction (GO:0045932)2.71708233
148negative regulation of necrotic cell death (GO:0060547)2.71273024
149cellular polysaccharide catabolic process (GO:0044247)2.71175586
150regulation of receptor recycling (GO:0001919)2.68705623
151cellular response to epinephrine stimulus (GO:0071872)2.68310478
152striated muscle hypertrophy (GO:0014897)2.65934606
153negative regulation of protein localization to cell surface (GO:2000009)2.62380651
154striated muscle adaptation (GO:0014888)2.62338162
155cellular response to dexamethasone stimulus (GO:0071549)2.59356764
156negative regulation of focal adhesion assembly (GO:0051895)2.57895092
157negative regulation of cell junction assembly (GO:1901889)2.57895092
158negative regulation of adherens junction organization (GO:1903392)2.57895092
159response to methylmercury (GO:0051597)2.57275737
160thrombin receptor signaling pathway (GO:0070493)2.54388695
161pigment biosynthetic process (GO:0046148)2.53628618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.78307310
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.34461229
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84666511
4* GATA1_19941826_ChIP-Seq_K562_Human3.54005277
5* GATA1_19941827_ChIP-Seq_MEL_Mouse3.12813167
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.06808190
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96363568
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.86555838
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.85793037
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84105911
11* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.68218620
12ZNF263_19887448_ChIP-Seq_K562_Human2.47844110
13EZH2_22144423_ChIP-Seq_EOC_Human2.32751859
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29917679
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.29689217
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22925370
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16322383
18GATA1_22383799_ChIP-Seq_G1ME_Mouse2.12658700
19NCOR1_26117541_ChIP-Seq_K562_Human2.10084345
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07615620
21* GATA2_19941826_ChIP-Seq_K562_Human2.07459460
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95962201
23GATA4_21415370_ChIP-Seq_HL-1_Mouse1.94505443
24MAF_26560356_Chip-Seq_TH1_Human1.86106951
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.85380517
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83071095
27VDR_21846776_ChIP-Seq_THP-1_Human1.82303178
28TCF7_22412390_ChIP-Seq_EML_Mouse1.78746174
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77941383
30GATA2_22383799_ChIP-Seq_G1ME_Mouse1.77870865
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.77390428
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77222959
33SCL_19346495_ChIP-Seq_HPC-7_Human1.75180537
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.73358654
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72458637
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72278380
37ZNF274_21170338_ChIP-Seq_K562_Hela1.72025706
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68745703
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.68475862
40VDR_24763502_ChIP-Seq_THP-1_Human1.64422358
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62164028
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61669572
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.60389345
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59886395
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59070089
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.57470414
47* TBX20_22080862_ChIP-Seq_HEART_Mouse1.57470414
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.54029442
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53875380
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.52317587
51KDM2B_26808549_Chip-Seq_DND41_Human1.50083067
52UTX_26944678_Chip-Seq_JUKART_Human1.48606189
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.48160982
54* EP300_21415370_ChIP-Seq_HL-1_Mouse1.48146410
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47236629
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46581477
57MYC_22102868_ChIP-Seq_BL_Human1.46308434
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.44479547
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42794731
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41708081
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40913458
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.37208442
63* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36973014
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35742631
65SPI1_23547873_ChIP-Seq_NB4_Human1.34721678
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34143240
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33172561
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32988983
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31573902
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31096751
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30956189
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30124532
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29292321
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28729173
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27058669
76RUNX_20019798_ChIP-Seq_JUKART_Human1.23974415
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23619590
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23311242
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22152138
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21943469
81* SPI1_20517297_ChIP-Seq_HL60_Human1.21822603
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.21224408
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.18761027
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18009813
85MYB_26560356_Chip-Seq_TH2_Human1.17896772
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15938270
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15893891
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15338645
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15078835
90MAF_26560356_Chip-Seq_TH2_Human1.14678346
91CTCF_27219007_Chip-Seq_Bcells_Human1.13511862
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13388525
93TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11993393
94STAT1_20625510_ChIP-Seq_HELA_Human1.10972446
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10844694
96REST_21632747_ChIP-Seq_MESCs_Mouse1.10443934
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10321494
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10223600
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09951416
100CIITA_25753668_ChIP-Seq_RAJI_Human1.09671402
101* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09647350
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09255648
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07304158
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06296234
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.05162851
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05012880
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.04682187
108PU_27001747_Chip-Seq_BMDM_Mouse1.03688177
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03644982
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03620803
111ERG_20517297_ChIP-Seq_VCAP_Human1.03617599
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02303964
113* BCL6_27268052_Chip-Seq_Bcells_Human1.01519909
114* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01432351
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01419055
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01042673
117* P68_20966046_ChIP-Seq_HELA_Human1.00850442
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99568034
119* YY1_22570637_ChIP-Seq_MALME-3M_Human0.99037767
120MYB_26560356_Chip-Seq_TH1_Human0.98332064
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98304957
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.98292178
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97841238
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97563355
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97350043
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96318994
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95676648
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95546955
129* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95439896
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94899792
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94386243
132LXR_22292898_ChIP-Seq_THP-1_Human0.94316875
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93894576
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93794558
135IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93734282
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.92975544
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92387291
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91985441
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90962699
140* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89897818
141* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89329716
142CTCF_21964334_Chip-Seq_Bcells_Human0.89148566
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89062275
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88434272
145SPI1_23127762_ChIP-Seq_K562_Human0.87739127
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87269334
147* BCOR_27268052_Chip-Seq_Bcells_Human0.87179184
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86722873
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86712906
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.85211613
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84565174
152TFEB_21752829_ChIP-Seq_HELA_Human0.82682007
153MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81358242
154HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80290489
155ATF3_27146783_Chip-Seq_COLON_Human0.80246508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.69423968
2MP0004147_increased_porphyrin_level4.59713664
3MP0003646_muscle_fatigue4.23261756
4MP0000749_muscle_degeneration4.04613190
5MP0003656_abnormal_erythrocyte_physiolo3.84513228
6MP0005451_abnormal_body_composition3.72626590
7MP0000751_myopathy3.65733722
8MP0004084_abnormal_cardiac_muscle3.64705105
9MP0004036_abnormal_muscle_relaxation3.49510152
10MP0005464_abnormal_platelet_physiology3.41711892
11MP0004215_abnormal_myocardial_fiber3.39493703
12MP0004145_abnormal_muscle_electrophysio3.07771923
13MP0000372_irregular_coat_pigmentation2.98571818
14MP0005171_absent_coat_pigmentation2.95601216
15MP0005330_cardiomyopathy2.65967157
16MP0006036_abnormal_mitochondrial_physio2.65414108
17MP0004043_abnormal_pH_regulation2.42371447
18MP0005620_abnormal_muscle_contractility2.40705182
19MP0002972_abnormal_cardiac_muscle2.31654533
20MP0008775_abnormal_heart_ventricle2.22094538
21MP0002106_abnormal_muscle_physiology2.11950874
22MP0002332_abnormal_exercise_endurance2.09338631
23MP0004087_abnormal_muscle_fiber2.09278255
24MP0000747_muscle_weakness2.09077729
25MP0003303_peritoneal_inflammation2.06040298
26MP0004859_abnormal_synaptic_plasticity2.04145340
27MP0001545_abnormal_hematopoietic_system1.98374436
28MP0005397_hematopoietic_system_phenotyp1.98374436
29MP0004484_altered_response_of1.97509308
30MP0002269_muscular_atrophy1.96706882
31MP0002877_abnormal_melanocyte_morpholog1.94080730
32MP0002909_abnormal_adrenal_gland1.93734836
33MP0000015_abnormal_ear_pigmentation1.91637143
34MP0008260_abnormal_autophagy1.87879370
35MP0004510_myositis1.87525037
36MP0000759_abnormal_skeletal_muscle1.84286364
37MP0000013_abnormal_adipose_tissue1.81936355
38MP0004130_abnormal_muscle_cell1.80326891
39MP0004085_abnormal_heartbeat1.76793548
40MP0003137_abnormal_impulse_conducting1.68014668
41MP0005369_muscle_phenotype1.66821904
42MP0000750_abnormal_muscle_regeneration1.62463847
43MP0003221_abnormal_cardiomyocyte_apopto1.59274964
44MP0001544_abnormal_cardiovascular_syste1.57012077
45MP0005385_cardiovascular_system_phenoty1.57012077
46MP0003724_increased_susceptibility_to1.54429028
47MP0008004_abnormal_stomach_pH1.45685400
48MP0009780_abnormal_chondrocyte_physiolo1.45579297
49MP0005075_abnormal_melanosome_morpholog1.41815550
50MP0002132_abnormal_respiratory_system1.39645839
51MP0004270_analgesia1.37287160
52MP0005636_abnormal_mineral_homeostasis1.35947853
53MP0010630_abnormal_cardiac_muscle1.35781186
54MP0006138_congestive_heart_failure1.33192868
55MP0000465_gastrointestinal_hemorrhage1.32935257
56MP0004233_abnormal_muscle_weight1.32293037
57MP0005058_abnormal_lysosome_morphology1.30893867
58MP0004381_abnormal_hair_follicle1.28583924
59MP0000343_altered_response_to1.28397557
60MP0003122_maternal_imprinting1.26731221
61MP0005535_abnormal_body_temperature1.26439262
62MP0003283_abnormal_digestive_organ1.22265198
63MP0005310_abnormal_salivary_gland1.21970223
64MP0003136_yellow_coat_color1.17022403
65MP0002693_abnormal_pancreas_physiology1.14493258
66MP0003880_abnormal_central_pattern1.13159071
67MP0003635_abnormal_synaptic_transmissio1.12872654
68MP0002735_abnormal_chemical_nociception1.12274108
69MP0009278_abnormal_bone_marrow1.11676554
70MP0002078_abnormal_glucose_homeostasis1.10747179
71MP0006035_abnormal_mitochondrial_morpho1.10739210
72MP0000230_abnormal_systemic_arterial1.08850981
73MP0003806_abnormal_nucleotide_metabolis1.08336854
74MP0005083_abnormal_biliary_tract1.06295359
75MP0002095_abnormal_skin_pigmentation1.06055263
76MP0003436_decreased_susceptibility_to1.03180258
77MP0002736_abnormal_nociception_after1.03167372
78MP0002234_abnormal_pharynx_morphology1.02695741
79MP0002822_catalepsy1.02300140
80MP0001765_abnormal_ion_homeostasis1.01452058
81MP0001529_abnormal_vocalization1.01038632
82MP0003879_abnormal_hair_cell0.99366401
83MP0009745_abnormal_behavioral_response0.99063583
84MP0001968_abnormal_touch/_nociception0.97640684
85MP0005174_abnormal_tail_pigmentation0.96971633
86MP0000003_abnormal_adipose_tissue0.96738683
87MP0002734_abnormal_mechanical_nocicepti0.94994401
88MP0010386_abnormal_urinary_bladder0.94419415
89MP0002419_abnormal_innate_immunity0.92981912
90MP0003172_abnormal_lysosome_physiology0.92621156
91MP0005266_abnormal_metabolism0.91981667
92MP0002398_abnormal_bone_marrow0.91748680
93MP0003828_pulmonary_edema0.90879412
94MP0003191_abnormal_cellular_cholesterol0.90373972
95MP0008961_abnormal_basal_metabolism0.90154569
96MP0005025_abnormal_response_to0.89918670
97MP0003186_abnormal_redox_activity0.89828073
98MP0005408_hypopigmentation0.89019854
99MP0001835_abnormal_antigen_presentation0.88343002
100MP0009840_abnormal_foam_cell0.85103339
101MP0006276_abnormal_autonomic_nervous0.83783619
102MP0002272_abnormal_nervous_system0.83357901
103MP0005167_abnormal_blood-brain_barrier0.82909607
104MP0002971_abnormal_brown_adipose0.81744325
105MP0004808_abnormal_hematopoietic_stem0.81216530
106MP0002064_seizures0.79175481
107MP0008569_lethality_at_weaning0.78990793
108MP0002733_abnormal_thermal_nociception0.78837438
109MP0002063_abnormal_learning/memory/cond0.78727752
110MP0000689_abnormal_spleen_morphology0.78637487
111MP0001661_extended_life_span0.77817638
112MP0001440_abnormal_grooming_behavior0.77512747
113MP0001970_abnormal_pain_threshold0.77281571
114MP0000266_abnormal_heart_morphology0.76842243
115MP0005670_abnormal_white_adipose0.76623160
116MP0000371_diluted_coat_color0.75810624
117MP0003045_fibrosis0.75660882
118MP0005386_behavior/neurological_phenoty0.75323005
119MP0004924_abnormal_behavior0.75323005
120MP0002148_abnormal_hypersensitivity_rea0.74376710
121MP0005165_increased_susceptibility_to0.73842010
122MP0002067_abnormal_sensory_capabilities0.73742686
123MP0002722_abnormal_immune_system0.73243397
124MP0004185_abnormal_adipocyte_glucose0.72978419
125MP0001944_abnormal_pancreas_morphology0.72724843
126MP0009785_altered_susceptibility_to0.72586123
127MP0005000_abnormal_immune_tolerance0.72203952
128MP0000685_abnormal_immune_system0.72185542
129MP0002127_abnormal_cardiovascular_syste0.71880116
130MP0003195_calcinosis0.71575015
131MP0005646_abnormal_pituitary_gland0.69343505
132MP0008872_abnormal_physiological_respon0.68456959
133MP0000678_abnormal_parathyroid_gland0.67617970
134MP0005375_adipose_tissue_phenotype0.66866266
135MP0009764_decreased_sensitivity_to0.66810014
136MP0002429_abnormal_blood_cell0.65963240
137MP0000733_abnormal_muscle_development0.65908229
138MP0009333_abnormal_splenocyte_physiolog0.65328384
139MP0002420_abnormal_adaptive_immunity0.65191075
140MP0003300_gastrointestinal_ulcer0.64268026
141MP0001790_abnormal_immune_system0.63858866
142MP0005387_immune_system_phenotype0.63858866
143MP0001819_abnormal_immune_cell0.63630295
144MP0009643_abnormal_urine_homeostasis0.63621602
145MP0001905_abnormal_dopamine_level0.62982986
146MP0005666_abnormal_adipose_tissue0.61630365
147MP0002572_abnormal_emotion/affect_behav0.61323835
148MP0008995_early_reproductive_senescence0.59524263
149MP0002723_abnormal_immune_serum0.59114982
150MP0003953_abnormal_hormone_level0.58488268
151MP0009763_increased_sensitivity_to0.58085757
152MP0009046_muscle_twitch0.57279259
153MP0004811_abnormal_neuron_physiology0.56635118
154MP0005595_abnormal_vascular_smooth0.54181273
155MP0005379_endocrine/exocrine_gland_phen0.53700846
156MP0005452_abnormal_adipose_tissue0.51321438
157MP0010368_abnormal_lymphatic_system0.49661393

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.84359051
2Myoglobinuria (HP:0002913)5.00957688
3Sudden death (HP:0001699)4.90378253
4Exercise-induced muscle cramps (HP:0003710)4.86641700
5Exercise-induced myalgia (HP:0003738)4.81544293
6Calf muscle hypertrophy (HP:0008981)4.77097867
7Prolonged bleeding time (HP:0003010)4.72568854
8Muscle hypertrophy of the lower extremities (HP:0008968)4.58335120
9Poikilocytosis (HP:0004447)4.28305706
10Hypochromic microcytic anemia (HP:0004840)3.99043414
11Reticulocytosis (HP:0001923)3.90151803
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.86980163
13Abnormal mitochondria in muscle tissue (HP:0008316)3.80731741
14Acute necrotizing encephalopathy (HP:0006965)3.77638185
15Abnormality of skeletal muscle fiber size (HP:0012084)3.69113137
16Abnormality of the calf musculature (HP:0001430)3.56852340
17Atrial fibrillation (HP:0005110)3.41882850
18Hepatic necrosis (HP:0002605)3.40032158
19Distal lower limb muscle weakness (HP:0009053)3.39119722
20Abnormality of the left ventricular outflow tract (HP:0011103)3.36923911
21Subaortic stenosis (HP:0001682)3.36923911
22Palpitations (HP:0001962)3.34522314
23Cholelithiasis (HP:0001081)3.34149454
24Ventricular tachycardia (HP:0004756)3.32432995
25Asymmetric septal hypertrophy (HP:0001670)3.24526278
26Neck muscle weakness (HP:0000467)3.22013974
27Primary atrial arrhythmia (HP:0001692)3.19912255
28Acute encephalopathy (HP:0006846)3.19376682
29Purpura (HP:0000979)3.16941489
30Mitochondrial inheritance (HP:0001427)3.16292788
31Bundle branch block (HP:0011710)3.15513415
32Rhabdomyolysis (HP:0003201)3.13851326
33Supraventricular tachycardia (HP:0004755)3.13737862
34Muscle fiber splitting (HP:0003555)3.13412379
35Round ear (HP:0100830)3.11603975
36Diaphragmatic weakness (HP:0009113)3.11445230
37EMG: myopathic abnormalities (HP:0003458)3.10990539
38Abnormal gallbladder morphology (HP:0012437)3.10602927
39Hepatocellular necrosis (HP:0001404)3.07955062
40Ragged-red muscle fibers (HP:0003200)3.07405844
41Supraventricular arrhythmia (HP:0005115)3.05847216
42Abnormal platelet volume (HP:0011876)3.04723329
43Ulnar deviation of the wrist (HP:0003049)3.02838684
44Increased mean platelet volume (HP:0011877)3.02703016
45Myotonia (HP:0002486)3.00527881
46Progressive macrocephaly (HP:0004481)2.99877994
47Epistaxis (HP:0000421)2.97555325
48Acanthocytosis (HP:0001927)2.95951440
49Pheochromocytoma (HP:0002666)2.95141695
50Microcytic anemia (HP:0001935)2.93996855
51Menorrhagia (HP:0000132)2.91699778
52Prolonged QT interval (HP:0001657)2.91429210
53Progressive muscle weakness (HP:0003323)2.90298042
54Areflexia of lower limbs (HP:0002522)2.89501731
55Ketoacidosis (HP:0001993)2.89217593
56Lipoatrophy (HP:0100578)2.84055780
57Increased CSF lactate (HP:0002490)2.79953390
58Syncope (HP:0001279)2.78321916
59Hypoglycemic coma (HP:0001325)2.75219176
60Neuroendocrine neoplasm (HP:0100634)2.74630167
61Dilated cardiomyopathy (HP:0001644)2.74601091
62Paralysis (HP:0003470)2.72017475
63EMG: neuropathic changes (HP:0003445)2.65140907
64Generalized aminoaciduria (HP:0002909)2.61163250
65Muscle fiber inclusion bodies (HP:0100299)2.60171769
66Frequent falls (HP:0002359)2.57579285
67Hyporeflexia of lower limbs (HP:0002600)2.57080391
68Exercise intolerance (HP:0003546)2.52492367
69Heart block (HP:0012722)2.51772127
70Hyperinsulinemic hypoglycemia (HP:0000825)2.51750589
71Increased muscle lipid content (HP:0009058)2.50267582
72Polycythemia (HP:0001901)2.49435791
73Lactic acidosis (HP:0003128)2.46336756
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46039464
75Abnormal atrioventricular conduction (HP:0005150)2.43730848
76Increased intramyocellular lipid droplets (HP:0012240)2.42394240
77Abnormal EKG (HP:0003115)2.42309055
78Muscle stiffness (HP:0003552)2.41383671
79Abnormal hemoglobin (HP:0011902)2.41337455
80Atrioventricular block (HP:0001678)2.40595781
81Hyperbilirubinemia (HP:0002904)2.35637391
82Left ventricular hypertrophy (HP:0001712)2.34786135
83Ventricular arrhythmia (HP:0004308)2.34465183
84Gingival bleeding (HP:0000225)2.33880984
85Hypochromic anemia (HP:0001931)2.32746098
86Testicular atrophy (HP:0000029)2.30749954
87Bulbar palsy (HP:0001283)2.30408966
88Decreased circulating renin level (HP:0003351)2.29736949
89Ventricular fibrillation (HP:0001663)2.29433603
90Distal lower limb amyotrophy (HP:0008944)2.28655566
91Abnormal platelet function (HP:0011869)2.28362553
92Impaired platelet aggregation (HP:0003540)2.28362553
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26137578
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26137578
95Calcaneovalgus deformity (HP:0001848)2.25870969
96Visual hallucinations (HP:0002367)2.21965431
97Anxiety (HP:0000739)2.19456261
98Type 1 muscle fiber predominance (HP:0003803)2.18357216
99Large for gestational age (HP:0001520)2.17920791
100Abnormality of iron homeostasis (HP:0011031)2.16908685
101Malignant hyperthermia (HP:0002047)2.16582128
102Generalized muscle weakness (HP:0003324)2.15619470
103Spontaneous hematomas (HP:0007420)2.11153790
104Difficulty running (HP:0009046)2.10924631
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10619980
106Respiratory failure (HP:0002878)2.08991327
107Difficulty climbing stairs (HP:0003551)2.08596639
108Cholecystitis (HP:0001082)2.07809935
109Abnormal gallbladder physiology (HP:0012438)2.07809935
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06094927
111Abnormality of alanine metabolism (HP:0010916)2.06094927
112Hyperalaninemia (HP:0003348)2.06094927
113Weak cry (HP:0001612)2.05675400
114Nemaline bodies (HP:0003798)2.05256233
115Cerebral edema (HP:0002181)2.04772574
116Poor eye contact (HP:0000817)2.03043288
117Absent phalangeal crease (HP:0006109)2.02205550
118Increased serum ferritin (HP:0003281)2.02087934
119Rimmed vacuoles (HP:0003805)2.01820011
120Febrile seizures (HP:0002373)2.01128330
121Abnormality of reticulocytes (HP:0004312)2.00910792
122Increased connective tissue (HP:0009025)2.00291699
123Gout (HP:0001997)1.99821993
124Petechiae (HP:0000967)1.98694941
125Late onset (HP:0003584)1.96934203
126Tinnitus (HP:0000360)1.96073012
127Hyperthyroidism (HP:0000836)1.95681976
128Albinism (HP:0001022)1.95646349
129Hyperkalemia (HP:0002153)1.95502192
130Scapular winging (HP:0003691)1.94775801
131Deformed tarsal bones (HP:0008119)1.92212962
132Abnormality of the gallbladder (HP:0005264)1.92210887
133Generalized tonic-clonic seizures (HP:0002069)1.91294569
134Distal arthrogryposis (HP:0005684)1.91093203
135Abnormality of the foot musculature (HP:0001436)1.90860666
136Abnormal pupillary function (HP:0007686)1.90483133
137Increased variability in muscle fiber diameter (HP:0003557)1.89974431
138Myopathic facies (HP:0002058)1.89905265
139Foot dorsiflexor weakness (HP:0009027)1.89528665
140Slender build (HP:0001533)1.89457848
141Ileus (HP:0002595)1.87368097
142Toxemia of pregnancy (HP:0100603)1.84109307
143Abnormality of transition element cation homeostasis (HP:0011030)1.82033475
144Hypertensive crisis (HP:0100735)1.81495800
145Fatigue (HP:0012378)1.79940116
146Stomatitis (HP:0010280)1.79373553
147Ocular albinism (HP:0001107)1.74522727
148Gowers sign (HP:0003391)1.72828694
149Nausea (HP:0002018)1.71603131
150Spinal rigidity (HP:0003306)1.70326321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.11237050
2TTN2.94312225
3MYLK2.84967156
4EIF2AK12.80759196
5PHKG12.71542796
6PHKG22.71542796
7MUSK2.69087908
8NEK12.47786122
9TAOK22.44342632
10NME12.41638677
11WNK42.38008706
12MAP3K122.23768604
13PDK32.19580942
14PDK42.19580942
15BCKDK2.15521060
16PINK12.00195150
17TRIB31.98278453
18NTRK31.96108498
19BMX1.92883105
20INSRR1.91415265
21PRKD31.83373241
22LMTK21.82450051
23PRPF4B1.78505891
24STK241.73215153
25TIE11.61628339
26PKN21.60235298
27FLT31.54404913
28MAPKAPK31.46613468
29MARK31.44845603
30GRK61.42661119
31ZAP701.38376472
32ARAF1.34924820
33GRK51.33524245
34BRSK11.33395430
35BLK1.32965438
36TRPM71.30102250
37MAP3K111.29362163
38CAMKK21.28791957
39TAOK11.24596720
40SYK1.23567910
41CDC42BPA1.23168735
42TNK21.21688355
43GRK71.16713256
44PDK21.14167736
45DMPK1.12129113
46MAP3K41.12068828
47TEC1.10912520
48MAP3K11.07349485
49BTK1.07268933
50BRAF1.05018352
51PASK1.02129174
52TBK11.02089724
53MAP2K31.00994416
54KDR1.00853460
55RPS6KA20.99762602
56MAP2K70.98354301
57TYK20.93410055
58MAP4K10.91042936
59PTK2B0.89406987
60MAPK150.89139699
61JAK30.88879702
62NTRK10.88559048
63MAP2K40.88275569
64ERN10.88212053
65HIPK20.88080245
66DAPK10.87637333
67HCK0.86889542
68KSR20.86681161
69UHMK10.85585496
70MINK10.85130536
71CLK10.81369426
72CCNB10.78415492
73WNK30.75961481
74SGK20.74931646
75FGR0.74779209
76ILK0.74228105
77PIM10.74154643
78FES0.72881922
79RAF10.72129430
80DYRK1B0.72020463
81JAK20.71988882
82RIPK40.71984740
83MAPK120.69984942
84RPS6KL10.69883258
85RPS6KC10.69883258
86CSK0.68561154
87PIK3CA0.68271356
88STK160.67338323
89SGK30.66226470
90PRKAA10.66095014
91MATK0.65671411
92MAP3K70.65669083
93DAPK30.64988670
94ZAK0.63656453
95CDK50.62651316
96MAP2K10.62490734
97MAP3K20.61425490
98ROCK10.61321861
99PRKAA20.60702742
100IKBKE0.60469752
101IRAK40.59282745
102CAMK2D0.58574875
103MAP3K60.57848539
104EPHB10.57742489
105RPS6KA60.57570269
106CAMK2A0.57259625
107BRSK20.57236241
108IKBKB0.56850756
109EPHA40.56366512
110MAP2K60.56338320
111PRKD20.55911704
112PDPK10.55413270
113ICK0.55384514
114PRKCH0.54777818
115MAPK110.54355855
116NEK90.54163524
117DAPK20.53852463
118IRAK30.52747423
119SGK2230.52623337
120SGK4940.52623337
121CDK190.51461003
122PRKACA0.50985339
123CAMKK10.50779689
124PRKACG0.49693610
125MARK20.49522786
126MAP3K130.49360772
127MAP3K50.49243510
128MAPKAPK50.49175036
129PAK30.48887583
130AKT20.48697416
131LYN0.47813731
132CAMK10.45599793
133MAP3K30.45377944
134MAPK40.45182139
135CDK80.45154057
136TAOK30.44513422
137STK40.43753629
138SGK10.43327521
139PDK10.43028028
140PIK3CG0.41951118
141PRKD10.40505400
142SCYL20.39260206
143MAPK70.35949287
144PAK10.34670246
145BMPR20.34486548
146MOS0.33670085
147PKN10.31488550
148ITK0.31100687
149CAMK40.29933479
150DYRK30.29223874
151KSR10.27579682

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.19240174
2Oxidative phosphorylation_Homo sapiens_hsa001903.84848911
3Parkinsons disease_Homo sapiens_hsa050123.79302395
4Cardiac muscle contraction_Homo sapiens_hsa042603.52476611
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.93217474
6Platelet activation_Homo sapiens_hsa046112.82385790
7Alzheimers disease_Homo sapiens_hsa050102.74105187
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44254464
9Huntingtons disease_Homo sapiens_hsa050162.39379330
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.38193782
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.34884407
12Malaria_Homo sapiens_hsa051442.23769864
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.22738635
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09615595
15Dilated cardiomyopathy_Homo sapiens_hsa054142.09526813
16Collecting duct acid secretion_Homo sapiens_hsa049662.08353036
17Pentose phosphate pathway_Homo sapiens_hsa000301.95808547
18Insulin secretion_Homo sapiens_hsa049111.87905225
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80480246
20Synaptic vesicle cycle_Homo sapiens_hsa047211.74948506
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69946792
22Osteoclast differentiation_Homo sapiens_hsa043801.68389400
23Acute myeloid leukemia_Homo sapiens_hsa052211.61270101
24B cell receptor signaling pathway_Homo sapiens_hsa046621.53168405
25Propanoate metabolism_Homo sapiens_hsa006401.50436176
26Carbon metabolism_Homo sapiens_hsa012001.45535282
27Hematopoietic cell lineage_Homo sapiens_hsa046401.43450011
28Non-small cell lung cancer_Homo sapiens_hsa052231.42611092
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41637661
30Pyruvate metabolism_Homo sapiens_hsa006201.38756144
31Glucagon signaling pathway_Homo sapiens_hsa049221.34377792
32Pancreatic cancer_Homo sapiens_hsa052121.29951412
33Long-term potentiation_Homo sapiens_hsa047201.27348331
34Circadian entrainment_Homo sapiens_hsa047131.26239461
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26149431
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25050988
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24031027
38Protein export_Homo sapiens_hsa030601.23551064
39Insulin signaling pathway_Homo sapiens_hsa049101.21668568
40Vibrio cholerae infection_Homo sapiens_hsa051101.20592870
41Amphetamine addiction_Homo sapiens_hsa050311.17540204
42Circadian rhythm_Homo sapiens_hsa047101.16042324
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.15969119
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14750644
45Leishmaniasis_Homo sapiens_hsa051401.13384996
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12587936
47Gastric acid secretion_Homo sapiens_hsa049711.11665277
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10319454
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09925286
50Chronic myeloid leukemia_Homo sapiens_hsa052201.08601179
51Olfactory transduction_Homo sapiens_hsa047401.08212655
52Calcium signaling pathway_Homo sapiens_hsa040201.07697367
53Sulfur metabolism_Homo sapiens_hsa009201.06104799
54Type II diabetes mellitus_Homo sapiens_hsa049301.04152488
55Galactose metabolism_Homo sapiens_hsa000521.04114719
56Fructose and mannose metabolism_Homo sapiens_hsa000511.01979098
57Oxytocin signaling pathway_Homo sapiens_hsa049211.01151923
58Salivary secretion_Homo sapiens_hsa049701.00783315
59Tuberculosis_Homo sapiens_hsa051521.00026299
60Taste transduction_Homo sapiens_hsa047420.99987165
61VEGF signaling pathway_Homo sapiens_hsa043700.99697941
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99572496
63Arginine and proline metabolism_Homo sapiens_hsa003300.99147604
64Fatty acid degradation_Homo sapiens_hsa000710.96284912
65Viral myocarditis_Homo sapiens_hsa054160.95139745
66Nitrogen metabolism_Homo sapiens_hsa009100.94709474
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91383858
68Dopaminergic synapse_Homo sapiens_hsa047280.91146808
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.88358010
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87989960
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87949722
72Measles_Homo sapiens_hsa051620.87687412
73Insulin resistance_Homo sapiens_hsa049310.87497718
74Renin secretion_Homo sapiens_hsa049240.87417989
75Morphine addiction_Homo sapiens_hsa050320.86718177
76Fatty acid elongation_Homo sapiens_hsa000620.86389029
77Chemokine signaling pathway_Homo sapiens_hsa040620.86281169
78GABAergic synapse_Homo sapiens_hsa047270.85635155
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82207016
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78790023
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77278159
82Cocaine addiction_Homo sapiens_hsa050300.77021228
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.76185402
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.74665110
85Tyrosine metabolism_Homo sapiens_hsa003500.74484339
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.73058251
87T cell receptor signaling pathway_Homo sapiens_hsa046600.71933247
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71745602
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71665172
90Renal cell carcinoma_Homo sapiens_hsa052110.71519364
91Gap junction_Homo sapiens_hsa045400.70087457
92mTOR signaling pathway_Homo sapiens_hsa041500.69897726
93Serotonergic synapse_Homo sapiens_hsa047260.67161911
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67128265
95Influenza A_Homo sapiens_hsa051640.66609125
96Butanoate metabolism_Homo sapiens_hsa006500.65578931
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65174066
98cAMP signaling pathway_Homo sapiens_hsa040240.64612815
99Cholinergic synapse_Homo sapiens_hsa047250.64242767
100Regulation of autophagy_Homo sapiens_hsa041400.64048228
101Toxoplasmosis_Homo sapiens_hsa051450.63552228
102Apoptosis_Homo sapiens_hsa042100.62676597
103African trypanosomiasis_Homo sapiens_hsa051430.61335456
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.60707598
105Other glycan degradation_Homo sapiens_hsa005110.60568509
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59181247
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.58987362
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58573736
109Inositol phosphate metabolism_Homo sapiens_hsa005620.58383877
110Nicotine addiction_Homo sapiens_hsa050330.58359861
111Endometrial cancer_Homo sapiens_hsa052130.58354157
112Amoebiasis_Homo sapiens_hsa051460.56968476
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56543352
114Hepatitis C_Homo sapiens_hsa051600.55043219
115GnRH signaling pathway_Homo sapiens_hsa049120.53850530
116AMPK signaling pathway_Homo sapiens_hsa041520.53825194
117Endocytosis_Homo sapiens_hsa041440.53606765
118Pancreatic secretion_Homo sapiens_hsa049720.53421922
119Herpes simplex infection_Homo sapiens_hsa051680.53162914
120Fatty acid metabolism_Homo sapiens_hsa012120.52956618
121Starch and sucrose metabolism_Homo sapiens_hsa005000.52910011
122Focal adhesion_Homo sapiens_hsa045100.52176959
123ABC transporters_Homo sapiens_hsa020100.51372978
124Staphylococcus aureus infection_Homo sapiens_hsa051500.50840267
125Bladder cancer_Homo sapiens_hsa052190.50542796
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49118468
127Hepatitis B_Homo sapiens_hsa051610.48850284
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47990824
129Glutamatergic synapse_Homo sapiens_hsa047240.46537876
130Glutathione metabolism_Homo sapiens_hsa004800.46233028
131TNF signaling pathway_Homo sapiens_hsa046680.45974682
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45933866
133Legionellosis_Homo sapiens_hsa051340.45536765
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45178480
135Biosynthesis of amino acids_Homo sapiens_hsa012300.44450554
136Small cell lung cancer_Homo sapiens_hsa052220.44237835
137Phagosome_Homo sapiens_hsa041450.43642569
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43384298
139Shigellosis_Homo sapiens_hsa051310.43339398
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42541961
141Prolactin signaling pathway_Homo sapiens_hsa049170.42334169
142Thyroid hormone synthesis_Homo sapiens_hsa049180.41450951
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39102808
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35783038
145Oocyte meiosis_Homo sapiens_hsa041140.34735128
146Estrogen signaling pathway_Homo sapiens_hsa049150.34408156
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34176933
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.33763455
149Alcoholism_Homo sapiens_hsa050340.31479603
150HIF-1 signaling pathway_Homo sapiens_hsa040660.30945826
151Metabolic pathways_Homo sapiens_hsa011000.30577938
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29762698
153Vitamin B6 metabolism_Homo sapiens_hsa007500.29694659
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27580984
155Long-term depression_Homo sapiens_hsa047300.25933154
156FoxO signaling pathway_Homo sapiens_hsa040680.24708744
157Glioma_Homo sapiens_hsa052140.22103881
158Thyroid cancer_Homo sapiens_hsa052160.21751230
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21175075
160Lysosome_Homo sapiens_hsa041420.20356577
161Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19948571
162Melanogenesis_Homo sapiens_hsa049160.18634416

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