GMPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.54551628
2mitotic chromosome condensation (GO:0007076)4.38186782
3establishment of integrated proviral latency (GO:0075713)4.37363313
4protein localization to kinetochore (GO:0034501)4.29676684
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.23166897
6CENP-A containing nucleosome assembly (GO:0034080)4.20257571
7nuclear pore organization (GO:0006999)4.14726040
8chromatin remodeling at centromere (GO:0031055)4.13949989
9protein deneddylation (GO:0000338)4.03708119
10protein localization to chromosome, centromeric region (GO:0071459)4.03023800
11DNA topological change (GO:0006265)3.94383296
12kinetochore organization (GO:0051383)3.85204287
13nuclear pore complex assembly (GO:0051292)3.83218901
14microtubule depolymerization (GO:0007019)3.82046093
15nuclear envelope disassembly (GO:0051081)3.80938926
16membrane disassembly (GO:0030397)3.80938926
17ribosome assembly (GO:0042255)3.78001790
18DNA double-strand break processing (GO:0000729)3.75889926
19DNA replication-independent nucleosome assembly (GO:0006336)3.75398419
20DNA replication-independent nucleosome organization (GO:0034724)3.75398419
21IMP biosynthetic process (GO:0006188)3.70884987
22regulation of translational fidelity (GO:0006450)3.70238240
23viral mRNA export from host cell nucleus (GO:0046784)3.69187511
24histone exchange (GO:0043486)3.65872222
25DNA replication initiation (GO:0006270)3.63968632
26non-recombinational repair (GO:0000726)3.63291062
27double-strand break repair via nonhomologous end joining (GO:0006303)3.63291062
28mitotic metaphase plate congression (GO:0007080)3.61947794
29DNA strand elongation involved in DNA replication (GO:0006271)3.61184035
30DNA strand elongation (GO:0022616)3.61106966
31mitotic sister chromatid cohesion (GO:0007064)3.58598349
32telomere maintenance via semi-conservative replication (GO:0032201)3.54595364
33DNA replication checkpoint (GO:0000076)3.53526583
34mitotic recombination (GO:0006312)3.46341009
35positive regulation of chromosome segregation (GO:0051984)3.46281308
36regulation of chromosome segregation (GO:0051983)3.46136991
37meiotic chromosome segregation (GO:0045132)3.44830953
38metaphase plate congression (GO:0051310)3.44168413
39folic acid-containing compound biosynthetic process (GO:0009396)3.43582834
40telomere maintenance via recombination (GO:0000722)3.43342871
41formation of translation preinitiation complex (GO:0001731)3.42434193
42DNA duplex unwinding (GO:0032508)3.42422932
43kinetochore assembly (GO:0051382)3.42003021
44regulation of mitotic spindle organization (GO:0060236)3.41450184
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41276685
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.41276685
47DNA ligation (GO:0006266)3.39215824
48mitotic sister chromatid segregation (GO:0000070)3.38570382
49heterochromatin organization (GO:0070828)3.38524885
50histone H2A acetylation (GO:0043968)3.38020732
51DNA geometric change (GO:0032392)3.36405253
52regulation of spindle organization (GO:0090224)3.34303556
53regulation of centrosome cycle (GO:0046605)3.33604898
54* nucleobase biosynthetic process (GO:0046112)3.31275802
55sister chromatid segregation (GO:0000819)3.30766170
56replication fork processing (GO:0031297)3.26770926
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26079055
58DNA replication-dependent nucleosome assembly (GO:0006335)3.24517557
59DNA replication-dependent nucleosome organization (GO:0034723)3.24517557
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19578777
61* purine nucleobase biosynthetic process (GO:0009113)3.19451574
62DNA unwinding involved in DNA replication (GO:0006268)3.17504390
63establishment of viral latency (GO:0019043)3.14730701
64chromatin assembly or disassembly (GO:0006333)3.14145951
65intra-S DNA damage checkpoint (GO:0031573)3.13623151
66DNA conformation change (GO:0071103)3.13222577
67regulation of sister chromatid cohesion (GO:0007063)3.12615422
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11372632
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11372632
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.09045705
71chromosome condensation (GO:0030261)3.08435830
72pre-miRNA processing (GO:0031054)3.07541366
73establishment of chromosome localization (GO:0051303)3.06939756
74protein K6-linked ubiquitination (GO:0085020)3.03813614
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03457966
76regulation of centriole replication (GO:0046599)3.02496976
77intraciliary transport (GO:0042073)3.01235909
78pore complex assembly (GO:0046931)3.00929824
79IMP metabolic process (GO:0046040)3.00502752
80L-serine metabolic process (GO:0006563)2.99968963
81attachment of spindle microtubules to kinetochore (GO:0008608)2.99517820
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99277884
83tRNA aminoacylation for protein translation (GO:0006418)2.99116700
84protein localization to chromosome (GO:0034502)2.98455938
85telomere maintenance via telomere lengthening (GO:0010833)2.97872209
86regulation of centrosome duplication (GO:0010824)2.97090140
87amino acid activation (GO:0043038)2.95960611
88tRNA aminoacylation (GO:0043039)2.95960611
89telomere maintenance (GO:0000723)2.95807644
90regulation of sister chromatid segregation (GO:0033045)2.95394887
91regulation of mitotic sister chromatid separation (GO:0010965)2.95394887
92regulation of mitotic sister chromatid segregation (GO:0033047)2.95394887
93mismatch repair (GO:0006298)2.94582585
94nuclear envelope organization (GO:0006998)2.94243439
95telomere organization (GO:0032200)2.93614440
96deoxyribonucleotide biosynthetic process (GO:0009263)2.93386863
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.93365230
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93365230
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93365230
100negative regulation of sister chromatid segregation (GO:0033046)2.93365230
101negative regulation of mRNA processing (GO:0050686)2.91589023
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90309091
103transcription elongation from RNA polymerase I promoter (GO:0006362)2.88868981
1047-methylguanosine mRNA capping (GO:0006370)2.88594190
105ribosome biogenesis (GO:0042254)2.87679570
106DNA strand renaturation (GO:0000733)2.87263064
107spindle checkpoint (GO:0031577)2.86911137
108protein complex localization (GO:0031503)2.86402938
109negative regulation of chromosome segregation (GO:0051985)2.86116377
110positive regulation of mitochondrial fission (GO:0090141)2.84932782
111spindle assembly checkpoint (GO:0071173)2.84850817
1127-methylguanosine RNA capping (GO:0009452)2.83896924
113RNA capping (GO:0036260)2.83896924
114mitotic spindle assembly checkpoint (GO:0007094)2.83503579
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83483104
116DNA catabolic process, exonucleolytic (GO:0000738)2.82842653
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82742361
118postreplication repair (GO:0006301)2.82619932
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.80795594
120transcription-coupled nucleotide-excision repair (GO:0006283)2.79407512
121mitotic nuclear envelope disassembly (GO:0007077)2.78349839
122snRNA processing (GO:0016180)2.77211467
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77012892
124RNA-dependent DNA replication (GO:0006278)2.76351035
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75337696
126regulation of mitotic spindle checkpoint (GO:1903504)2.75337696
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75032555
128termination of RNA polymerase I transcription (GO:0006363)2.74226212
129maturation of 5.8S rRNA (GO:0000460)2.73146441
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72817503
131DNA damage response, detection of DNA damage (GO:0042769)2.72156832
132positive regulation of mitotic sister chromatid separation (GO:1901970)2.72128173
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72128173
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72128173
135chromosome segregation (GO:0007059)2.71605632
136histone arginine methylation (GO:0034969)2.71152974
137mitotic spindle checkpoint (GO:0071174)2.70424451
1382-deoxyribonucleotide biosynthetic process (GO:0009265)2.69587224
139deoxyribose phosphate biosynthetic process (GO:0046385)2.69587224
140ATP-dependent chromatin remodeling (GO:0043044)2.69441688
141G1/S transition of mitotic cell cycle (GO:0000082)2.68810946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.76707919
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.74218013
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72860036
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70783847
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11340361
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.84418114
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.83027369
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78943373
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60624095
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49916683
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48169250
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46656487
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45535762
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.43142267
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39176572
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37080121
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.33461747
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30158224
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.24695123
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16710226
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15749167
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13142433
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07679359
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03755191
25ELK1_19687146_ChIP-ChIP_HELA_Human2.02479891
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99413112
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.98964452
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.93596568
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92151377
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90959592
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87462379
32VDR_23849224_ChIP-Seq_CD4+_Human1.82777028
33EWS_26573619_Chip-Seq_HEK293_Human1.79341616
34FUS_26573619_Chip-Seq_HEK293_Human1.78478284
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76017439
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73317353
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71734829
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71049179
39* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66828190
40* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66149406
41FOXP3_21729870_ChIP-Seq_TREG_Human1.62441666
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61048680
43TAF15_26573619_Chip-Seq_HEK293_Human1.60719244
44GBX2_23144817_ChIP-Seq_PC3_Human1.60373505
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60243745
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53198920
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.52314736
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48953749
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48259013
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.44883725
51GABP_19822575_ChIP-Seq_HepG2_Human1.41316093
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.40854526
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40755177
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38002699
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36450888
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36401459
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35270204
58AR_21909140_ChIP-Seq_LNCAP_Human1.34284492
59DCP1A_22483619_ChIP-Seq_HELA_Human1.33311501
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.32292317
61VDR_22108803_ChIP-Seq_LS180_Human1.29662324
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29331328
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28331063
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25868224
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25618623
66TTF2_22483619_ChIP-Seq_HELA_Human1.25600436
67IRF1_19129219_ChIP-ChIP_H3396_Human1.24828433
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23932621
69MYC_18940864_ChIP-ChIP_HL60_Human1.21685397
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21477042
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20427905
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19156198
73XRN2_22483619_ChIP-Seq_HELA_Human1.18691990
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14609853
75RNF2_27304074_Chip-Seq_NSC_Mouse1.12929443
76SOX9_26525672_Chip-Seq_HEART_Mouse1.10059725
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08411323
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05897564
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05481686
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04744836
81P300_19829295_ChIP-Seq_ESCs_Human1.03338162
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02889329
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02591303
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.02475621
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02343882
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.00178890
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98253150
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97345880
89IGF1R_20145208_ChIP-Seq_DFB_Human0.96600767
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95631579
91CHD1_26751641_Chip-Seq_LNCaP_Human0.95431726
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95234849
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95228993
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94111528
95CIITA_25753668_ChIP-Seq_RAJI_Human0.93140653
96* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92801822
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92072885
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91447080
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.90315158
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89462325
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87642698
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85946961
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85052717
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84676684
105TFEB_21752829_ChIP-Seq_HELA_Human0.82416509
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81932442
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80698237
108* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80571798
109* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80507443
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79646924
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.79500122
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.78041185
113* KDM5A_27292631_Chip-Seq_BREAST_Human0.77325096
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.76871007
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76855294
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76853795
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76219973
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75948167
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75944556
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75386942
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73012053
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72870821
123ZNF263_19887448_ChIP-Seq_K562_Human0.69649686
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.68857834
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67136022
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.63771741
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.63118692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.90878093
2MP0010094_abnormal_chromosome_stability3.84085893
3MP0003787_abnormal_imprinting3.74652475
4MP0003123_paternal_imprinting3.51305606
5MP0003121_genomic_imprinting3.40987697
6MP0008058_abnormal_DNA_repair3.21394384
7MP0008057_abnormal_DNA_replication2.99278442
8MP0003122_maternal_imprinting2.86811963
9MP0004957_abnormal_blastocyst_morpholog2.65939878
10MP0003693_abnormal_embryo_hatching2.62251853
11MP0003111_abnormal_nucleus_morphology2.56145697
12MP0001188_hyperpigmentation2.47237818
13MP0003077_abnormal_cell_cycle2.44921761
14MP0008007_abnormal_cellular_replicative2.37825602
15MP0009697_abnormal_copulation2.32518624
16MP0006292_abnormal_olfactory_placode2.21373615
17MP0004147_increased_porphyrin_level2.18764996
18MP0010352_gastrointestinal_tract_polyps1.92972903
19MP0002160_abnormal_reproductive_system1.83888240
20MP0008932_abnormal_embryonic_tissue1.83654001
21MP0003786_premature_aging1.79453193
22MP0003890_abnormal_embryonic-extraembry1.78519612
23MP0010307_abnormal_tumor_latency1.67797737
24MP0002009_preneoplasia1.64417013
25MP0005646_abnormal_pituitary_gland1.63357706
26MP0008789_abnormal_olfactory_epithelium1.55998559
27MP0001529_abnormal_vocalization1.51452329
28MP0005394_taste/olfaction_phenotype1.51242709
29MP0005499_abnormal_olfactory_system1.51242709
30MP0000537_abnormal_urethra_morphology1.47259491
31MP0002210_abnormal_sex_determination1.46395615
32MP0000566_synostosis1.42372303
33MP0002751_abnormal_autonomic_nervous1.38934053
34MP0000516_abnormal_urinary_system1.34667540
35MP0005367_renal/urinary_system_phenotyp1.34667540
36MP0003941_abnormal_skin_development1.32603485
37MP0003880_abnormal_central_pattern1.28924744
38MP0005389_reproductive_system_phenotype1.28292146
39MP0001929_abnormal_gametogenesis1.25513573
40MP0002396_abnormal_hematopoietic_system1.24522752
41MP0002697_abnormal_eye_size1.24184551
42MP0000015_abnormal_ear_pigmentation1.23840347
43MP0000350_abnormal_cell_proliferation1.23494726
44MP0003315_abnormal_perineum_morphology1.22265382
45MP0002086_abnormal_extraembryonic_tissu1.22140538
46MP0003119_abnormal_digestive_system1.21201439
47MP0010030_abnormal_orbit_morphology1.19482007
48MP0009053_abnormal_anal_canal1.18321486
49MP0005171_absent_coat_pigmentation1.17502655
50MP0002938_white_spotting1.16292740
51MP0003385_abnormal_body_wall1.15051130
52MP0002877_abnormal_melanocyte_morpholog1.13115641
53MP0003698_abnormal_male_reproductive1.13004217
54MP0003942_abnormal_urinary_system1.12959355
55MP0001346_abnormal_lacrimal_gland1.12406892
56MP0000358_abnormal_cell_content/1.11532024
57MP0002653_abnormal_ependyma_morphology1.11333801
58MP0001672_abnormal_embryogenesis/_devel1.07612827
59MP0005380_embryogenesis_phenotype1.07612827
60MP0002736_abnormal_nociception_after1.07328342
61MP0002111_abnormal_tail_morphology1.05920490
62MP0002163_abnormal_gland_morphology1.05856906
63MP0001145_abnormal_male_reproductive1.05495732
64MP0000372_irregular_coat_pigmentation1.04458887
65MP0001984_abnormal_olfaction1.04405254
66MP0003943_abnormal_hepatobiliary_system1.03510113
67MP0001730_embryonic_growth_arrest1.01099288
68MP0010234_abnormal_vibrissa_follicle1.00652394
69MP0001661_extended_life_span1.00621223
70MP0000653_abnormal_sex_gland1.00486731
71MP0000579_abnormal_nail_morphology1.00102342
72MP0000647_abnormal_sebaceous_gland0.99681752
73MP0001119_abnormal_female_reproductive0.99524478
74MP0000428_abnormal_craniofacial_morphol0.99397658
75MP0000631_abnormal_neuroendocrine_gland0.99016643
76MP0001697_abnormal_embryo_size0.98747718
77MP0004197_abnormal_fetal_growth/weight/0.96891202
78MP0003984_embryonic_growth_retardation0.96869054
79MP0001919_abnormal_reproductive_system0.96738586
80MP0001177_atelectasis0.96055113
81MP0001986_abnormal_taste_sensitivity0.95505579
82MP0000049_abnormal_middle_ear0.94489656
83MP0002638_abnormal_pupillary_reflex0.93880543
84MP0002088_abnormal_embryonic_growth/wei0.93334886
85MP0006072_abnormal_retinal_apoptosis0.91422320
86MP0005076_abnormal_cell_differentiation0.91408208
87MP0003755_abnormal_palate_morphology0.91140287
88MP0009250_abnormal_appendicular_skeleto0.90529995
89MP0002876_abnormal_thyroid_physiology0.90242223
90MP0002092_abnormal_eye_morphology0.89715468
91MP0005187_abnormal_penis_morphology0.89520572
92MP0002233_abnormal_nose_morphology0.89097776
93MP0001299_abnormal_eye_distance/0.87422187
94MP0006035_abnormal_mitochondrial_morpho0.87296470
95MP0005409_darkened_coat_color0.85750165
96MP0006276_abnormal_autonomic_nervous0.85272195
97MP0002085_abnormal_embryonic_tissue0.84143854
98MP0003937_abnormal_limbs/digits/tail_de0.82963504
99MP0001968_abnormal_touch/_nociception0.81827316
100MP0005410_abnormal_fertilization0.81610309
101MP0004782_abnormal_surfactant_physiolog0.81391134
102MP0004233_abnormal_muscle_weight0.80309649
103MP0001286_abnormal_eye_development0.79858779
104MP0001293_anophthalmia0.78590527
105MP0003115_abnormal_respiratory_system0.77173361
106MP0003935_abnormal_craniofacial_develop0.77163595
107MP0002019_abnormal_tumor_incidence0.76151687
108MP0002177_abnormal_outer_ear0.76125580
109MP0002080_prenatal_lethality0.75838441
110MP0000778_abnormal_nervous_system0.75021637
111MP0002102_abnormal_ear_morphology0.74327739
112MP0005384_cellular_phenotype0.74236391
113MP0009672_abnormal_birth_weight0.73295607
114MP0002084_abnormal_developmental_patter0.72747502
115MP0000432_abnormal_head_morphology0.72657655
116MP0003861_abnormal_nervous_system0.72507876
117MP0000534_abnormal_ureter_morphology0.72484670
118MP0009046_muscle_twitch0.71971085
119MP0000678_abnormal_parathyroid_gland0.71953812
120MP0005501_abnormal_skin_physiology0.71709792
121MP0003567_abnormal_fetal_cardiomyocyte0.71316882
122MP0003718_maternal_effect0.70890741
123MP0002161_abnormal_fertility/fecundity0.70833465
124MP0004808_abnormal_hematopoietic_stem0.69958793
125MP0000313_abnormal_cell_death0.69655034
126MP0002063_abnormal_learning/memory/cond0.69483334
127MP0009703_decreased_birth_body0.68252718
128MP0000490_abnormal_crypts_of0.66963826
129MP0003221_abnormal_cardiomyocyte_apopto0.66797459
130MP0005408_hypopigmentation0.64853380
131MP0008995_early_reproductive_senescence0.63241791
132MP0004185_abnormal_adipocyte_glucose0.61188014
133MP0005391_vision/eye_phenotype0.61045258
134MP0005621_abnormal_cell_physiology0.60530169
135MP0002081_perinatal_lethality0.60397545
136MP0005248_abnormal_Harderian_gland0.60194873
137MP0010678_abnormal_skin_adnexa0.59248652
138MP0002254_reproductive_system_inflammat0.58305342

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.53893535
2Increased nuchal translucency (HP:0010880)3.32586789
3Abnormal lung lobation (HP:0002101)3.14054831
4Chromsome breakage (HP:0040012)3.09749803
5Abnormality of the labia minora (HP:0012880)3.09519058
6Embryonal renal neoplasm (HP:0011794)3.09027211
7Abnormal hair whorl (HP:0010721)3.06542536
8Nephroblastoma (Wilms tumor) (HP:0002667)3.04178328
9Cortical dysplasia (HP:0002539)2.96087155
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94216006
11Abnormality of the anterior horn cell (HP:0006802)2.72773633
12Degeneration of anterior horn cells (HP:0002398)2.72773633
13Abnormality of the carotid arteries (HP:0005344)2.61055023
14Medial flaring of the eyebrow (HP:0010747)2.57602185
15Congenital primary aphakia (HP:0007707)2.55948111
16Nephrogenic diabetes insipidus (HP:0009806)2.55846463
17Gait imbalance (HP:0002141)2.52964671
18Supernumerary spleens (HP:0009799)2.52461735
19Agnosia (HP:0010524)2.51128298
20Meckel diverticulum (HP:0002245)2.50781098
21Glioma (HP:0009733)2.48401535
22Medulloblastoma (HP:0002885)2.47658738
23Absent radius (HP:0003974)2.46361142
24True hermaphroditism (HP:0010459)2.44230162
25Colon cancer (HP:0003003)2.43681395
26Abnormality of chromosome stability (HP:0003220)2.43283301
27Poor coordination (HP:0002370)2.42557167
28Patellar aplasia (HP:0006443)2.41930652
29Hyperventilation (HP:0002883)2.36982199
30Abnormality of the ileum (HP:0001549)2.36775843
31Reticulocytopenia (HP:0001896)2.36714255
32Protruding tongue (HP:0010808)2.36702999
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.35788041
34Aplasia involving forearm bones (HP:0009822)2.31054947
35Absent forearm bone (HP:0003953)2.31054947
36Febrile seizures (HP:0002373)2.30342886
37Pancreatic fibrosis (HP:0100732)2.29928245
38Papillary thyroid carcinoma (HP:0002895)2.28439820
39Multiple enchondromatosis (HP:0005701)2.25763360
40Abnormality of the preputium (HP:0100587)2.24527988
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.24108988
42Astrocytoma (HP:0009592)2.23308759
43Abnormality of the astrocytes (HP:0100707)2.23308759
44Aplasia/Hypoplasia of the patella (HP:0006498)2.21562939
45Facial cleft (HP:0002006)2.19694229
46Triphalangeal thumb (HP:0001199)2.17246679
47Genital tract atresia (HP:0001827)2.16935124
48Absent eyebrow (HP:0002223)2.15476387
49Ectopic kidney (HP:0000086)2.14582230
50Microvesicular hepatic steatosis (HP:0001414)2.13263323
51Vaginal atresia (HP:0000148)2.12022510
52Type I transferrin isoform profile (HP:0003642)2.09675119
53Duodenal stenosis (HP:0100867)2.08705268
54Small intestinal stenosis (HP:0012848)2.08705268
55Abnormality of methionine metabolism (HP:0010901)2.07281555
56Neoplasm of the colon (HP:0100273)2.06413139
57Cafe-au-lait spot (HP:0000957)2.05945733
58Hepatoblastoma (HP:0002884)2.04938627
59Abnormal mitochondria in muscle tissue (HP:0008316)2.03776365
60Choanal atresia (HP:0000453)2.02929665
61Pancreatic cysts (HP:0001737)2.01901291
62Selective tooth agenesis (HP:0001592)2.01771297
63Acute necrotizing encephalopathy (HP:0006965)2.01463705
64Impulsivity (HP:0100710)1.98696580
65Embryonal neoplasm (HP:0002898)1.97613506
66Nephronophthisis (HP:0000090)1.97362428
67Preaxial hand polydactyly (HP:0001177)1.97241452
68Deep philtrum (HP:0002002)1.96919528
6911 pairs of ribs (HP:0000878)1.95805303
70Horseshoe kidney (HP:0000085)1.94038870
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93512106
72High anterior hairline (HP:0009890)1.93440797
73Overlapping toe (HP:0001845)1.93412163
74Increased CSF lactate (HP:0002490)1.93374523
75Postaxial foot polydactyly (HP:0001830)1.93328900
76Volvulus (HP:0002580)1.90404326
77Neuroblastoma (HP:0003006)1.89913058
78Primitive neuroectodermal tumor (HP:0030065)1.89913058
79Neuroblastic tumors (HP:0004376)1.89913058
80Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89913058
81Optic nerve coloboma (HP:0000588)1.89188070
82Hypoplastic left heart (HP:0004383)1.89071486
83Thyroid carcinoma (HP:0002890)1.87047237
84Neoplasm of the adrenal gland (HP:0100631)1.86121717
85Homocystinuria (HP:0002156)1.83990708
86Abnormality of homocysteine metabolism (HP:0010919)1.83990708
87Proximal placement of thumb (HP:0009623)1.83928573
88Epileptic encephalopathy (HP:0200134)1.83822729
89Breast carcinoma (HP:0003002)1.83593705
90Pancreatic islet-cell hyperplasia (HP:0004510)1.83183111
91Myelodysplasia (HP:0002863)1.82981751
92Diastasis recti (HP:0001540)1.82918278
93Broad foot (HP:0001769)1.82841061
94Sloping forehead (HP:0000340)1.80766649
95Abnormality of glycolysis (HP:0004366)1.80666349
96Increased serum pyruvate (HP:0003542)1.80666349
97Rhabdomyosarcoma (HP:0002859)1.80510238
98Bifid tongue (HP:0010297)1.78171778
99Clubbing of toes (HP:0100760)1.77176111
100Abnormality of cochlea (HP:0000375)1.77006277
101Abnormality of the duodenum (HP:0002246)1.75733459
102Overriding aorta (HP:0002623)1.75404024
103Microglossia (HP:0000171)1.75139981
104Renal hypoplasia (HP:0000089)1.74708807
105Progressive macrocephaly (HP:0004481)1.74110322
106Long foot (HP:0001833)1.73933290
107Ependymoma (HP:0002888)1.73867910
108Partial agenesis of the corpus callosum (HP:0001338)1.72988541
109Deviation of the thumb (HP:0009603)1.71827878
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.71507160
111Postnatal microcephaly (HP:0005484)1.71077930
112Abnormal gallbladder physiology (HP:0012438)1.70765092
113Cholecystitis (HP:0001082)1.70765092
114Arteriovenous malformation (HP:0100026)1.70352084
115Hypoplasia of the pons (HP:0012110)1.70203143
116Freckling (HP:0001480)1.69820023
117Absent eyelashes (HP:0000561)1.68939984
118Mitochondrial inheritance (HP:0001427)1.68238142
119Neoplasm of the adrenal cortex (HP:0100641)1.68090710
120Asymmetry of the thorax (HP:0001555)1.67447770
121Spastic diplegia (HP:0001264)1.66294374
122Short thumb (HP:0009778)1.66262725
123Breast hypoplasia (HP:0003187)1.66207093
124Shawl scrotum (HP:0000049)1.65649305
125Abnormality of midbrain morphology (HP:0002418)1.65500989
126Molar tooth sign on MRI (HP:0002419)1.65500989
127Increased serum lactate (HP:0002151)1.65082776
128Bone marrow hypocellularity (HP:0005528)1.64178649
129Short 4th metacarpal (HP:0010044)1.63639546
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63639546
131Short tibia (HP:0005736)1.63494761
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63205783
133Abnormality of alanine metabolism (HP:0010916)1.63205783
134Hyperalaninemia (HP:0003348)1.63205783
135Intestinal atresia (HP:0011100)1.62517204
136Alveolar cell carcinoma (HP:0006519)1.62356283
137Duplication of thumb phalanx (HP:0009942)1.62279421
138Facial hemangioma (HP:0000329)1.61084259
139Shoulder girdle muscle weakness (HP:0003547)1.60719270
140Absent/shortened dynein arms (HP:0200106)1.60384621
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.60384621
142Atresia of the external auditory canal (HP:0000413)1.58990151
143Neoplasm of the small intestine (HP:0100833)1.57049663
144Neoplasm of striated muscle (HP:0009728)1.56743847
145Abnormal number of incisors (HP:0011064)1.56547860
146Obsessive-compulsive behavior (HP:0000722)1.54776920
147Duplicated collecting system (HP:0000081)1.54260780
148Increased hepatocellular lipid droplets (HP:0006565)1.52107959
149Ovarian neoplasm (HP:0100615)1.50697972
150Hypoplastic pelvis (HP:0008839)1.50404115
151Abnormality of chromosome segregation (HP:0002916)1.49043544
152Urethral obstruction (HP:0000796)1.48322917
153Absent thumb (HP:0009777)1.47343243
154Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.46883763
155Irregular epiphyses (HP:0010582)1.45063325
156* Acute myeloid leukemia (HP:0004808)1.43790819
157Nervous tissue neoplasm (HP:0030060)1.43487107
158Neuroectodermal neoplasm (HP:0030061)1.43487107
159Neuroepithelial neoplasm (HP:0030063)1.43487107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.18921488
2AKT33.37243770
3CDC73.04746740
4TSSK62.85100507
5BUB12.79069402
6SRPK12.70301875
7CCNB12.58680018
8PBK2.55553631
9EIF2AK12.36080934
10VRK22.28208538
11PLK32.23342871
12MKNK12.20394469
13MKNK22.09723108
14ACVR1B2.09471334
15PRPF4B2.09061204
16ZAK1.97911744
17PLK41.97847429
18MAP2K71.94385319
19PDK31.92766446
20PDK41.92766446
21PLK21.80061460
22VRK11.79249943
23ERBB31.77522978
24TAF11.76858847
25BRSK21.73838470
26SIK31.64898455
27SGK21.62077340
28WEE11.59662511
29SCYL21.58164754
30TRIM281.52870318
31CDK81.51982130
32MAP3K121.51525549
33EIF2AK31.47699609
34PASK1.46873999
35LATS11.45176471
36MAP3K101.43467027
37SMG11.37213711
38NEK11.34468455
39BRAF1.32270645
40BRSK11.31572291
41EEF2K1.29648463
42YES11.29639602
43PLK11.28580687
44STK161.27745911
45ATR1.21862473
46STK38L1.20993352
47RPS6KB21.20355749
48BCR1.20303897
49PNCK1.16875823
50CDK121.15888652
51CHEK21.09880226
52TTK1.08617324
53DAPK11.05594317
54TAOK21.02091221
55BMPR1B1.01286911
56MAPK130.98855318
57ALK0.96206911
58PDK20.95492409
59NEK90.95097773
60RPS6KA40.94334509
61SGK30.90260101
62EIF2AK20.90036044
63NUAK10.89985992
64EPHA40.86188054
65TNIK0.85799793
66STK240.85629619
67AURKB0.85515721
68SGK4940.84198572
69SGK2230.84198572
70TGFBR10.84142580
71RPS6KB10.83979284
72MAP3K40.83916383
73NEK60.83243398
74BMPR20.83150138
75CHEK10.82434439
76MAP3K80.81931939
77WNK30.80122913
78BRD40.79450097
79TXK0.79280639
80ATM0.79238191
81CSNK1G10.77799589
82FRK0.76556005
83NEK20.71904925
84MYLK0.70430107
85CDK60.70036814
86STK40.69518285
87DYRK30.66923411
88AURKA0.66904403
89CSNK1G30.64436219
90NME10.63983599
91CDK40.62750569
92LATS20.61897146
93CSNK1A1L0.61230445
94ADRBK20.58985197
95* CDK10.58498529
96CSNK2A10.57261347
97CSNK1E0.56995917
98PAK40.56965886
99MINK10.56566526
100NTRK30.55936750
101CDK70.54462840
102* CDK20.52034596
103CLK10.49818589
104DYRK20.49574551
105MELK0.49162604
106CSNK2A20.48113468
107MARK10.47111361
108KSR10.44129504
109OBSCN0.43819165
110RAF10.42351466
111CDK180.42265457
112CDK30.41797252
113PRKCG0.41757459
114MET0.40812363
115MST40.40310855
116NME20.40283199
117RPS6KC10.40015114
118RPS6KL10.40015114
119TESK10.39786026
120CSNK1G20.39561294
121CDK150.37274975
122CDK11A0.36725914
123TLK10.36156399
124RPS6KA20.35701450
125CDK140.35127240
126ERBB40.34651237
127PAK20.34438789
128RPS6KA60.34339307
129MAPKAPK50.34053892
130CAMK1G0.32998155
131PINK10.32912263
132TNK20.31660035
133ADRBK10.31066906
134FGFR10.30581879
135STK100.30119168
136CDK190.29354669
137PIK3CA0.29096435
138MAPK140.28657936
139MAP2K40.27873875
140RPS6KA50.27395026
141STK30.27139052
142PRKDC0.24721791

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15888186
2Mismatch repair_Homo sapiens_hsa034304.06335388
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38131773
4Proteasome_Homo sapiens_hsa030503.37524325
5RNA polymerase_Homo sapiens_hsa030203.11085922
6Base excision repair_Homo sapiens_hsa034103.02352089
7Nucleotide excision repair_Homo sapiens_hsa034202.92126574
8Non-homologous end-joining_Homo sapiens_hsa034502.85727641
9Homologous recombination_Homo sapiens_hsa034402.83040035
10RNA transport_Homo sapiens_hsa030132.80877258
11Spliceosome_Homo sapiens_hsa030402.79077805
12Cell cycle_Homo sapiens_hsa041102.73776812
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58341884
14Fanconi anemia pathway_Homo sapiens_hsa034602.45807132
15Basal transcription factors_Homo sapiens_hsa030222.35351510
16RNA degradation_Homo sapiens_hsa030182.29491067
17Pyrimidine metabolism_Homo sapiens_hsa002402.19739234
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18989700
19One carbon pool by folate_Homo sapiens_hsa006702.17737725
20mRNA surveillance pathway_Homo sapiens_hsa030151.99476406
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57805622
22Protein export_Homo sapiens_hsa030601.56882084
23* Purine metabolism_Homo sapiens_hsa002301.54951314
24Nicotine addiction_Homo sapiens_hsa050331.43938966
25Oocyte meiosis_Homo sapiens_hsa041141.33758737
26Steroid biosynthesis_Homo sapiens_hsa001001.29800535
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23229993
28Huntingtons disease_Homo sapiens_hsa050161.23092011
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20646459
30Propanoate metabolism_Homo sapiens_hsa006401.19879551
31Collecting duct acid secretion_Homo sapiens_hsa049661.19477371
32Oxidative phosphorylation_Homo sapiens_hsa001901.14615931
33Parkinsons disease_Homo sapiens_hsa050121.12845771
34Synaptic vesicle cycle_Homo sapiens_hsa047211.00592659
35Lysine degradation_Homo sapiens_hsa003100.99168826
36Epstein-Barr virus infection_Homo sapiens_hsa051690.98376323
37Fatty acid elongation_Homo sapiens_hsa000620.92873171
38Vibrio cholerae infection_Homo sapiens_hsa051100.90298013
39Systemic lupus erythematosus_Homo sapiens_hsa053220.85887566
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82642882
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.81223803
42p53 signaling pathway_Homo sapiens_hsa041150.80274741
43Pentose phosphate pathway_Homo sapiens_hsa000300.79565720
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77851211
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75495364
46Thyroid cancer_Homo sapiens_hsa052160.72068837
47Alcoholism_Homo sapiens_hsa050340.72062696
48Pyruvate metabolism_Homo sapiens_hsa006200.71945252
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69187643
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68225647
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66300281
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.64901426
53Selenocompound metabolism_Homo sapiens_hsa004500.64849624
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63883056
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61628077
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61456290
57Olfactory transduction_Homo sapiens_hsa047400.60538228
58Adherens junction_Homo sapiens_hsa045200.60455944
59Biosynthesis of amino acids_Homo sapiens_hsa012300.58577837
60Type I diabetes mellitus_Homo sapiens_hsa049400.57037554
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57001800
62Viral carcinogenesis_Homo sapiens_hsa052030.56631328
63HTLV-I infection_Homo sapiens_hsa051660.55504610
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54831220
65Fatty acid metabolism_Homo sapiens_hsa012120.54369075
66N-Glycan biosynthesis_Homo sapiens_hsa005100.52191595
67Alzheimers disease_Homo sapiens_hsa050100.51015531
68Carbon metabolism_Homo sapiens_hsa012000.50297613
69Amphetamine addiction_Homo sapiens_hsa050310.50253645
70Melanoma_Homo sapiens_hsa052180.50157934
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50119444
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47696097
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47405152
74Taste transduction_Homo sapiens_hsa047420.46890656
75Morphine addiction_Homo sapiens_hsa050320.46840710
76Long-term potentiation_Homo sapiens_hsa047200.46528546
77Vitamin B6 metabolism_Homo sapiens_hsa007500.45548275
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45365156
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44545508
80Folate biosynthesis_Homo sapiens_hsa007900.44181310
81Hippo signaling pathway_Homo sapiens_hsa043900.43929290
82Colorectal cancer_Homo sapiens_hsa052100.43688713
83TGF-beta signaling pathway_Homo sapiens_hsa043500.42599456
84Glutathione metabolism_Homo sapiens_hsa004800.40874915
85Ribosome_Homo sapiens_hsa030100.40848901
86Endometrial cancer_Homo sapiens_hsa052130.40630528
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40405178
88Hedgehog signaling pathway_Homo sapiens_hsa043400.40362477
89Basal cell carcinoma_Homo sapiens_hsa052170.39712391
90Legionellosis_Homo sapiens_hsa051340.39066657
91Wnt signaling pathway_Homo sapiens_hsa043100.36415202
92Small cell lung cancer_Homo sapiens_hsa052220.35919650
93Fructose and mannose metabolism_Homo sapiens_hsa000510.35855690
94Dopaminergic synapse_Homo sapiens_hsa047280.35711862
95Herpes simplex infection_Homo sapiens_hsa051680.35102113
96MicroRNAs in cancer_Homo sapiens_hsa052060.33457738
97Chronic myeloid leukemia_Homo sapiens_hsa052200.32568665
98Phototransduction_Homo sapiens_hsa047440.32521872
99Sulfur relay system_Homo sapiens_hsa041220.31152998
100Bladder cancer_Homo sapiens_hsa052190.30904330
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30054397
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29502219
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28354108
104GABAergic synapse_Homo sapiens_hsa047270.26822294
105Serotonergic synapse_Homo sapiens_hsa047260.26731012
106Butanoate metabolism_Homo sapiens_hsa006500.26344576
107* Metabolic pathways_Homo sapiens_hsa011000.25098268
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24497391
109Arginine and proline metabolism_Homo sapiens_hsa003300.24059659
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.23516183
111Tight junction_Homo sapiens_hsa045300.23447516
112Circadian entrainment_Homo sapiens_hsa047130.22567751
113Phagosome_Homo sapiens_hsa041450.22506271
114Pancreatic cancer_Homo sapiens_hsa052120.22019362
115Antigen processing and presentation_Homo sapiens_hsa046120.20720298
116Arginine biosynthesis_Homo sapiens_hsa002200.19800293
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18972909
118Nitrogen metabolism_Homo sapiens_hsa009100.18724789
119Prostate cancer_Homo sapiens_hsa052150.18062355
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17615976
121Glucagon signaling pathway_Homo sapiens_hsa049220.17554169
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16385048
123HIF-1 signaling pathway_Homo sapiens_hsa040660.12489226
124Arachidonic acid metabolism_Homo sapiens_hsa005900.10294715
125Pathways in cancer_Homo sapiens_hsa052000.09850611
126Glioma_Homo sapiens_hsa052140.09497959
127Hepatitis B_Homo sapiens_hsa051610.09347850
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08876993
129Galactose metabolism_Homo sapiens_hsa000520.08866839
130Non-small cell lung cancer_Homo sapiens_hsa052230.08608545
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07294634
132Fatty acid biosynthesis_Homo sapiens_hsa000610.07119557

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