ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.75564676
2	translational termination (GO:0006415)	7.46021762
3	ribosomal small subunit assembly (GO:0000028)	7.06340357
4	ATP synthesis coupled proton transport (GO:0015986)	6.76043006
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.76043006
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.67691341
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.61058229
8	ribosomal small subunit biogenesis (GO:0042274)	6.56098808
9	cotranslational protein targeting to membrane (GO:0006613)	6.52698297
10	protein targeting to ER (GO:0045047)	6.47521002
11	maturation of SSU-rRNA (GO:0030490)	6.36595315
12	chaperone-mediated protein transport (GO:0072321)	6.20936802
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.17814335
14	translational elongation (GO:0006414)	6.12334227
15	protein localization to endoplasmic reticulum (GO:0070972)	6.10925354
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.01881502
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.95137445
18	cellular protein complex disassembly (GO:0043624)	5.72058208
19	viral life cycle (GO:0019058)	5.62213183
20	protein neddylation (GO:0045116)	5.55934255
21	respiratory electron transport chain (GO:0022904)	5.44001938
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.36415559
23	electron transport chain (GO:0022900)	5.36001843
24	protein complex biogenesis (GO:0070271)	5.31587323
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.19202051
26	NADH dehydrogenase complex assembly (GO:0010257)	5.19202051
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.19202051
28	translational initiation (GO:0006413)	4.91171621
29	mitochondrial respiratory chain complex assembly (GO:0033108)	4.86559193
30	protein complex disassembly (GO:0043241)	4.84845014
31	macromolecular complex disassembly (GO:0032984)	4.65564050
32	behavioral response to nicotine (GO:0035095)	4.64714794
33	protein targeting to membrane (GO:0006612)	4.42743978
34	translation (GO:0006412)	4.41901356
35	GTP biosynthetic process (GO:0006183)	4.39995369
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.98728380
37	ribosomal large subunit biogenesis (GO:0042273)	3.95647417
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.94555486
39	nonmotile primary cilium assembly (GO:0035058)	3.92978874
40	ATP biosynthetic process (GO:0006754)	3.85696699
41	hydrogen ion transmembrane transport (GO:1902600)	3.83940186
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.77284828
43	UTP biosynthetic process (GO:0006228)	3.75507950
44	mRNA catabolic process (GO:0006402)	3.58594097
45	cytochrome complex assembly (GO:0017004)	3.53881311
46	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.53323319
47	respiratory chain complex IV assembly (GO:0008535)	3.50878971
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.49879892
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.49879892
50	cellular component biogenesis (GO:0044085)	3.48162410
51	UTP metabolic process (GO:0046051)	3.46099973
52	proton transport (GO:0015992)	3.36920323
53	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.30577067
54	substrate-independent telencephalic tangential migration (GO:0021826)	3.30577067
55	hydrogen transport (GO:0006818)	3.29586393
56	RNA catabolic process (GO:0006401)	3.28834447
57	CTP metabolic process (GO:0046036)	3.25174846
58	CTP biosynthetic process (GO:0006241)	3.25174846
59	sequestering of actin monomers (GO:0042989)	3.21811375
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20106838
61	termination of RNA polymerase III transcription (GO:0006386)	3.18886299
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18886299
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.17979278
64	nucleoside triphosphate biosynthetic process (GO:0009142)	3.16561030
65	establishment of protein localization to membrane (GO:0090150)	3.15874035
66	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.14818394
67	spliceosomal complex assembly (GO:0000245)	3.12168398
68	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.08344321
69	regulation of cilium movement (GO:0003352)	3.07404787
70	oxidative phosphorylation (GO:0006119)	3.05494808
71	protein targeting (GO:0006605)	3.03242256
72	ribonucleoprotein complex biogenesis (GO:0022613)	3.01475356
73	guanosine-containing compound biosynthetic process (GO:1901070)	2.99869803
74	cell proliferation in forebrain (GO:0021846)	2.96721281
75	epithelial cilium movement (GO:0003351)	2.93839459
76	intracellular protein transmembrane import (GO:0044743)	2.93132312
77	intraciliary transport (GO:0042073)	2.89100864
78	pattern specification involved in kidney development (GO:0061004)	2.85628265
79	protein targeting to mitochondrion (GO:0006626)	2.85175989
80	resolution of meiotic recombination intermediates (GO:0000712)	2.85159179
81	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.84979517
82	negative regulation of response to food (GO:0032096)	2.83811428
83	negative regulation of appetite (GO:0032099)	2.83811428
84	protein-cofactor linkage (GO:0018065)	2.83631933
85	establishment of protein localization to mitochondrion (GO:0072655)	2.83328950
86	synaptic transmission, cholinergic (GO:0007271)	2.82868020
87	aldehyde catabolic process (GO:0046185)	2.80289263
88	inner mitochondrial membrane organization (GO:0007007)	2.78406702
89	regulation of mitochondrial translation (GO:0070129)	2.77550394
90	establishment of protein localization to organelle (GO:0072594)	2.75147762
91	kinetochore assembly (GO:0051382)	2.73453323
92	left/right pattern formation (GO:0060972)	2.71244668
93	protein localization to mitochondrion (GO:0070585)	2.69988771
94	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.68519444
95	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.68075135
96	chromatin remodeling at centromere (GO:0031055)	2.67390527
97	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.66332133
98	hypothalamus development (GO:0021854)	2.63503365
99	spliceosomal snRNP assembly (GO:0000387)	2.63038091
100	nucleoside diphosphate phosphorylation (GO:0006165)	2.59363287

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.27651177
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.31308516
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.18033719
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.71745685
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.09263729
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01891914
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00435103
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.90451956
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.81710139
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.81167002
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.79545003
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.73366752
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33702615
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18133645
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08285723
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.02228044
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.98424097
18	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.94959043
19	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.90152869
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85917307
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.84489171
22	TTF2_22483619_ChIP-Seq_HELA_Human	1.79978702
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.78990605
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77187324
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.69899888
26	VDR_22108803_ChIP-Seq_LS180_Human	1.67462244
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.66614638
28	XRN2_22483619_ChIP-Seq_HELA_Human	1.65870169
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.62358695
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.61704305
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.61442497
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57606685
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56373157
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53712453
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50379581
36	E2F7_22180533_ChIP-Seq_HELA_Human	1.50127616
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.49411526
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.46063544
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43177225
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41895579
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41670244
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41239810
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40411060
44	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.36735324
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.32786756
46	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.29275479
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.27441443
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22612416
49	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.22021086
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21505405
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.18522706
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18349984
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15419634
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.15375701
55	EWS_26573619_Chip-Seq_HEK293_Human	1.14825288
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11444514
57	NCOR_22424771_ChIP-Seq_293T_Human	1.09613970
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.08457804
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08371659
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07630981
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06787858
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06509704
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06387593
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.04010565
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03305577
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02142302
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95783530
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95363104
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95226937
70	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94940421
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.94170889
72	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92239131
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.92202891
74	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90818100
75	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.90708634
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.89574128
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89140084
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.89068559
79	ERA_21632823_ChIP-Seq_H3396_Human	0.88986016
80	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.88480443
81	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.88068883
82	P300_19829295_ChIP-Seq_ESCs_Human	0.87336485
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.86423038
84	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.86123455
85	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.85797442
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84541007
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.84224461
88	FUS_26573619_Chip-Seq_HEK293_Human	0.83792011
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.82959823
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.82845838
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.82799381
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.82745126
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.81781753
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.81599999
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.81539281
96	IGF1R_20145208_ChIP-Seq_DFB_Human	0.81488350
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79416097
98	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.79229871
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.78454396
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78009533

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.15237613
2	MP0006292_abnormal_olfactory_placode	3.58497945
3	MP0003787_abnormal_imprinting	2.88897160
4	MP0003123_paternal_imprinting	2.87480081
5	MP0002837_dystrophic_cardiac_calcinosis	2.79621625
6	MP0001529_abnormal_vocalization	2.65117678
7	MP0008789_abnormal_olfactory_epithelium	2.62352557
8	MP0002163_abnormal_gland_morphology	2.59967867
9	MP0004885_abnormal_endolymph	2.29797305
10	MP0001485_abnormal_pinna_reflex	2.25087784
11	MP0002653_abnormal_ependyma_morphology	2.25084486
12	MP0003646_muscle_fatigue	2.18706491
13	MP0002822_catalepsy	2.15354604
14	MP0005394_taste/olfaction_phenotype	2.13358783
15	MP0005499_abnormal_olfactory_system	2.13358783
16	MP0003121_genomic_imprinting	2.08471128
17	MP0006072_abnormal_retinal_apoptosis	2.03826910
18	MP0005084_abnormal_gallbladder_morpholo	2.03190259
19	MP0002736_abnormal_nociception_after	1.92780694
20	MP0003122_maternal_imprinting	1.90174713
21	MP0001293_anophthalmia	1.88798783
22	MP0001968_abnormal_touch/_nociception	1.87165257
23	MP0003878_abnormal_ear_physiology	1.86313265
24	MP0005377_hearing/vestibular/ear_phenot	1.86313265
25	MP0003186_abnormal_redox_activity	1.79418822
26	MP0005379_endocrine/exocrine_gland_phen	1.72081183
27	MP0000631_abnormal_neuroendocrine_gland	1.68311119
28	MP0004142_abnormal_muscle_tone	1.63186676
29	MP0005646_abnormal_pituitary_gland	1.61519482
30	MP0004147_increased_porphyrin_level	1.60919647
31	MP0006276_abnormal_autonomic_nervous	1.58124297
32	MP0002938_white_spotting	1.55463459
33	MP0002638_abnormal_pupillary_reflex	1.54323517
34	MP0002160_abnormal_reproductive_system	1.54147686
35	MP0001905_abnormal_dopamine_level	1.50776636
36	MP0005551_abnormal_eye_electrophysiolog	1.48983850
37	MP0010030_abnormal_orbit_morphology	1.47985343
38	MP0001919_abnormal_reproductive_system	1.42843226
39	MP0005389_reproductive_system_phenotype	1.40737300
40	MP0000778_abnormal_nervous_system	1.27412175
41	MP0003136_yellow_coat_color	1.24649413
42	MP0002272_abnormal_nervous_system	1.24374685
43	MP0008877_abnormal_DNA_methylation	1.23495790
44	MP0001970_abnormal_pain_threshold	1.22624344
45	MP0000049_abnormal_middle_ear	1.21364823
46	MP0001984_abnormal_olfaction	1.19411766
47	MP0001440_abnormal_grooming_behavior	1.18897605
48	MP0001486_abnormal_startle_reflex	1.18874990
49	MP0005670_abnormal_white_adipose	1.16553233
50	MP0004145_abnormal_muscle_electrophysio	1.15652640
51	MP0003880_abnormal_central_pattern	1.14985762
52	MP0002733_abnormal_thermal_nociception	1.11697897
53	MP0009745_abnormal_behavioral_response	1.10140496
54	MP0005195_abnormal_posterior_eye	1.09611778
55	MP0002234_abnormal_pharynx_morphology	1.09449558
56	MP0002572_abnormal_emotion/affect_behav	1.08202467
57	MP0002557_abnormal_social/conspecific_i	1.06918623
58	MP0006036_abnormal_mitochondrial_physio	1.06532588
59	MP0000026_abnormal_inner_ear	1.05388426
60	MP0009053_abnormal_anal_canal	1.05160997
61	MP0002735_abnormal_chemical_nociception	1.05087765
62	MP0003806_abnormal_nucleotide_metabolis	1.03767286
63	MP0002233_abnormal_nose_morphology	1.03486890
64	MP0004133_heterotaxia	1.02963821
65	MP0001188_hyperpigmentation	0.99975265
66	MP0002928_abnormal_bile_duct	0.98392075
67	MP0008058_abnormal_DNA_repair	0.98318992
68	MP0001286_abnormal_eye_development	0.97771295
69	MP0003119_abnormal_digestive_system	0.97163845
70	MP0003011_delayed_dark_adaptation	0.97122518
71	MP0001963_abnormal_hearing_physiology	0.95374452
72	MP0001756_abnormal_urination	0.94090205
73	MP0002752_abnormal_somatic_nervous	0.93781167
74	MP0002095_abnormal_skin_pigmentation	0.92945937
75	MP0008775_abnormal_heart_ventricle	0.90454401
76	MP0000372_irregular_coat_pigmentation	0.90112226
77	MP0002067_abnormal_sensory_capabilities	0.85563916
78	MP0002734_abnormal_mechanical_nocicepti	0.84883920
79	MP0002210_abnormal_sex_determination	0.84569505
80	MP0002063_abnormal_learning/memory/cond	0.84340286
81	MP0005386_behavior/neurological_phenoty	0.83573294
82	MP0004924_abnormal_behavior	0.83573294
83	MP0002184_abnormal_innervation	0.83336314
84	MP0001986_abnormal_taste_sensitivity	0.82238260
85	MP0003635_abnormal_synaptic_transmissio	0.81935591
86	MP0000955_abnormal_spinal_cord	0.80646789
87	MP0008872_abnormal_physiological_respon	0.80239328
88	MP0004742_abnormal_vestibular_system	0.73556068
89	MP0005423_abnormal_somatic_nervous	0.72843241
90	MP0005253_abnormal_eye_physiology	0.71107870
91	MP0009046_muscle_twitch	0.69251869
92	MP0002882_abnormal_neuron_morphology	0.68684343
93	MP0000230_abnormal_systemic_arterial	0.68547495
94	MP0002277_abnormal_respiratory_mucosa	0.68454647
95	MP0003195_calcinosis	0.68348944
96	MP0005332_abnormal_amino_acid	0.68320594
97	MP0002064_seizures	0.67712799
98	MP0002282_abnormal_trachea_morphology	0.66924929
99	MP0010386_abnormal_urinary_bladder	0.66566701
100	MP0001929_abnormal_gametogenesis	0.65883848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.05763160
2	Acute encephalopathy (HP:0006846)	5.52152287
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.32793619
4	Mitochondrial inheritance (HP:0001427)	5.13817591
5	Progressive macrocephaly (HP:0004481)	5.03939178
6	Increased hepatocellular lipid droplets (HP:0006565)	4.70326526
7	Lipid accumulation in hepatocytes (HP:0006561)	4.50132115
8	Reticulocytopenia (HP:0001896)	4.47768027
9	Increased CSF lactate (HP:0002490)	4.40679965
10	Hepatocellular necrosis (HP:0001404)	4.28686298
11	Renal Fanconi syndrome (HP:0001994)	4.24340077
12	Abnormality of cells of the erythroid lineage (HP:0012130)	4.19126481
13	Macrocytic anemia (HP:0001972)	3.84557621
14	Cerebral edema (HP:0002181)	3.81544209
15	Hepatic necrosis (HP:0002605)	3.77851262
16	Medial flaring of the eyebrow (HP:0010747)	3.70047986
17	Abnormal number of erythroid precursors (HP:0012131)	3.52084654
18	Increased intramyocellular lipid droplets (HP:0012240)	3.22854566
19	Gait imbalance (HP:0002141)	3.21052535
20	Abnormality of renal resorption (HP:0011038)	3.18840248
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.16751428
22	Abnormality of midbrain morphology (HP:0002418)	3.15890065
23	Molar tooth sign on MRI (HP:0002419)	3.15890065
24	Congenital primary aphakia (HP:0007707)	3.11169262
25	Exertional dyspnea (HP:0002875)	3.09750263
26	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.08007493
27	3-Methylglutaconic aciduria (HP:0003535)	3.06168285
28	Nephrogenic diabetes insipidus (HP:0009806)	2.95971612
29	True hermaphroditism (HP:0010459)	2.93862866
30	Optic disc pallor (HP:0000543)	2.93447015
31	Pancreatic cysts (HP:0001737)	2.90559047
32	Septo-optic dysplasia (HP:0100842)	2.89216469
33	Respiratory difficulties (HP:0002880)	2.84704310
34	Increased muscle lipid content (HP:0009058)	2.80703988
35	Pancreatic fibrosis (HP:0100732)	2.80212023
36	Hyperglycinemia (HP:0002154)	2.77466056
37	Colon cancer (HP:0003003)	2.75440760
38	Sclerocornea (HP:0000647)	2.74767250
39	Congenital, generalized hypertrichosis (HP:0004540)	2.73706082
40	Pallor (HP:0000980)	2.73225722
41	Leukodystrophy (HP:0002415)	2.71748272
42	Lactic acidosis (HP:0003128)	2.67663274
43	Increased serum lactate (HP:0002151)	2.64536207
44	Respiratory failure (HP:0002878)	2.61177736
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54672073
46	Exercise intolerance (HP:0003546)	2.52722784
47	Poor coordination (HP:0002370)	2.44943130
48	Myokymia (HP:0002411)	2.41637795
49	Absent thumb (HP:0009777)	2.38845520
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.36824835
51	Vaginal atresia (HP:0000148)	2.32243889
52	Hyperphosphaturia (HP:0003109)	2.30403032
53	Abnormality of urine glucose concentration (HP:0011016)	2.27976886
54	Glycosuria (HP:0003076)	2.27976886
55	Genital tract atresia (HP:0001827)	2.22532390
56	Lethargy (HP:0001254)	2.12755598
57	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10673480
58	Rib fusion (HP:0000902)	2.10626004
59	Anencephaly (HP:0002323)	2.09505059
60	Absent septum pellucidum (HP:0001331)	2.09244103
61	X-linked dominant inheritance (HP:0001423)	2.08372677
62	Abnormal ciliary motility (HP:0012262)	2.07022710
63	Nephronophthisis (HP:0000090)	2.05868979
64	Maternal diabetes (HP:0009800)	2.05472960
65	Abnormal respiratory motile cilium physiology (HP:0012261)	2.02311261
66	Anophthalmia (HP:0000528)	2.02207250
67	Type 2 muscle fiber atrophy (HP:0003554)	2.01027990
68	Cystic liver disease (HP:0006706)	1.93557088
69	Abnormality of the labia minora (HP:0012880)	1.93071756
70	Absent/shortened dynein arms (HP:0200106)	1.88294521
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88294521
72	Delayed CNS myelination (HP:0002188)	1.87593134
73	Male pseudohermaphroditism (HP:0000037)	1.87407659
74	Neoplasm of the adrenal cortex (HP:0100641)	1.84947963
75	Left ventricular hypertrophy (HP:0001712)	1.83384399
76	Type II lissencephaly (HP:0007260)	1.83309692
77	Adrenal hypoplasia (HP:0000835)	1.79897651
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78974296
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78974296
80	Hepatoblastoma (HP:0002884)	1.78957162
81	Congenital stationary night blindness (HP:0007642)	1.77021382
82	Abnormal urine phosphate concentration (HP:0012599)	1.76267536
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76081643
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.76081643
85	Depressed nasal ridge (HP:0000457)	1.73874138
86	Poor suck (HP:0002033)	1.71665797
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69645782
88	Muscle fiber atrophy (HP:0100295)	1.69566589
89	Supernumerary spleens (HP:0009799)	1.68911406
90	Rectal fistula (HP:0100590)	1.68641932
91	Rectovaginal fistula (HP:0000143)	1.68641932
92	Asplenia (HP:0001746)	1.66911972
93	Postaxial foot polydactyly (HP:0001830)	1.66395797
94	Triphalangeal thumb (HP:0001199)	1.65728524
95	Abnormality of DNA repair (HP:0003254)	1.65419472
96	Hypoplasia of the radius (HP:0002984)	1.64145012
97	Optic nerve hypoplasia (HP:0000609)	1.62764188
98	Abnormality of the septum pellucidum (HP:0007375)	1.62592880
99	Abnormality of the anterior horn cell (HP:0006802)	1.62158635
100	Degeneration of anterior horn cells (HP:0002398)	1.62158635

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.64090644
2	VRK2	3.67982732
3	MAP3K12	2.69366070
4	DYRK2	2.54592243
5	CDC7	2.36587819
6	PLK4	2.29331451
7	WNK3	2.27788121
8	MAP4K2	2.26564814
9	WNK4	2.17591860
10	ZAK	2.01871161
11	NEK1	2.01119885
12	TLK1	2.00766781
13	TAF1	2.00728274
14	BCKDK	1.89437885
15	CASK	1.87732524
16	ADRBK2	1.85168145
17	VRK1	1.83233261
18	LIMK1	1.71139619
19	EPHB2	1.65753985
20	NUAK1	1.64137467
21	NME1	1.52560676
22	PIK3CA	1.51601016
23	CDK19	1.50121852
24	FRK	1.49333709
25	GRK1	1.45431478
26	TIE1	1.41396480
27	NME2	1.27793661
28	MARK1	1.26280929
29	MAP3K4	1.19414649
30	MAPK15	1.15620253
31	TSSK6	1.09605085
32	MAP2K7	1.06720948
33	PLK3	1.05819103
34	MAPK13	1.04971847
35	INSRR	1.03567528
36	DAPK3	1.02481916
37	PINK1	0.97895553
38	ABL2	0.97210815
39	NEK2	0.96841447
40	BRAF	0.95745161
41	STK39	0.95403163
42	CHEK2	0.92842558
43	PRKCG	0.91892799
44	TNIK	0.90538937
45	BMPR1B	0.88631226
46	PRKD3	0.81312785
47	MKNK2	0.80736335
48	OXSR1	0.78865759
49	CAMKK2	0.75752513
50	LRRK2	0.75106716
51	NTRK2	0.74343739
52	CSNK1G3	0.73836721
53	CSNK1G2	0.73371322
54	TEC	0.73273273
55	MYLK	0.71318979
56	ADRBK1	0.70687791
57	PLK1	0.70039375
58	MINK1	0.68883440
59	CSNK2A2	0.68115443
60	TYRO3	0.67257647
61	CAMK1	0.66011158
62	EPHA4	0.64983174
63	STK11	0.64050991
64	ILK	0.61688108
65	CSNK1G1	0.59671243
66	AURKB	0.59568829
67	MUSK	0.59304853
68	CSNK2A1	0.56969557
69	PASK	0.55243260
70	STK3	0.54087786
71	TAOK3	0.51455458
72	RPS6KA5	0.50991812
73	AURKA	0.50712796
74	PRKACA	0.49797523
75	PLK2	0.48582188
76	PHKG2	0.48557088
77	PHKG1	0.48557088
78	CSNK1E	0.47382883
79	MAP3K11	0.45912743
80	PIM2	0.43924363
81	MAP2K4	0.42363040
82	ATR	0.42229440
83	MAPKAPK5	0.42019010
84	IRAK2	0.41903226
85	CAMK2D	0.40945882
86	CDK8	0.40793987
87	TESK1	0.40379357
88	CAMK1D	0.38566449
89	CSNK1A1	0.37095312
90	CSNK1A1L	0.36288188
91	PRKCQ	0.34628732
92	DAPK1	0.33448342
93	CDK14	0.33215723
94	WEE1	0.33095277
95	BMPR2	0.33089539
96	CAMKK1	0.32965111
97	ERBB3	0.32701932
98	MKNK1	0.30389874
99	CAMK2A	0.29748131
100	PAK1	0.29470181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.59608520
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.28582937
3	Parkinsons disease_Homo sapiens_hsa05012	4.50494810
4	Huntingtons disease_Homo sapiens_hsa05016	3.18212739
5	Protein export_Homo sapiens_hsa03060	3.14718059
6	Alzheimers disease_Homo sapiens_hsa05010	3.06816264
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.85663014
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.83506071
9	RNA polymerase_Homo sapiens_hsa03020	2.72044726
10	Proteasome_Homo sapiens_hsa03050	2.53857792
11	Mismatch repair_Homo sapiens_hsa03430	2.38106549
12	DNA replication_Homo sapiens_hsa03030	2.24473931
13	Homologous recombination_Homo sapiens_hsa03440	2.04970771
14	Sulfur relay system_Homo sapiens_hsa04122	1.92044550
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55853774
16	Phototransduction_Homo sapiens_hsa04744	1.49643752
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45836504
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.36872625
19	RNA degradation_Homo sapiens_hsa03018	1.36324957
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35083634
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30765203
22	Basal transcription factors_Homo sapiens_hsa03022	1.30732885
23	Spliceosome_Homo sapiens_hsa03040	1.23551337
24	Base excision repair_Homo sapiens_hsa03410	1.15566172
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13396506
26	Purine metabolism_Homo sapiens_hsa00230	1.08661266
27	One carbon pool by folate_Homo sapiens_hsa00670	1.04307702
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02687892
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98538011
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96612751
31	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94391265
32	Sulfur metabolism_Homo sapiens_hsa00920	0.94349582
33	Nicotine addiction_Homo sapiens_hsa05033	0.93474555
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93364675
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.91600048
36	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88033494
37	Propanoate metabolism_Homo sapiens_hsa00640	0.87233920
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83352828
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82751528
40	Folate biosynthesis_Homo sapiens_hsa00790	0.82377614
41	Basal cell carcinoma_Homo sapiens_hsa05217	0.80644376
42	Metabolic pathways_Homo sapiens_hsa01100	0.78656490
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75481399
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75463929
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70672002
46	Butanoate metabolism_Homo sapiens_hsa00650	0.70666572
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70624879
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67293851
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.67044687
50	Peroxisome_Homo sapiens_hsa04146	0.66600604
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.66324624
52	RNA transport_Homo sapiens_hsa03013	0.64453926
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64186270
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62751404
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.61990682
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61717102
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61379081
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.61276668
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60908781
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58420239
61	Olfactory transduction_Homo sapiens_hsa04740	0.57132768
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56304255
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54046001
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52661968
65	Asthma_Homo sapiens_hsa05310	0.52314622
66	Glutathione metabolism_Homo sapiens_hsa00480	0.52154340
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51241112
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.50275231
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50177886
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48458859
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46502510
72	Fatty acid degradation_Homo sapiens_hsa00071	0.44339631
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.42673903
74	Morphine addiction_Homo sapiens_hsa05032	0.41218290
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36404283
76	Retinol metabolism_Homo sapiens_hsa00830	0.36319755
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33890166
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.30680437
79	Serotonergic synapse_Homo sapiens_hsa04726	0.26179757
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25248324
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.24598281
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23398279
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.22571135
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21354344
85	GABAergic synapse_Homo sapiens_hsa04727	0.20894152
86	Fatty acid elongation_Homo sapiens_hsa00062	0.20481134
87	Mineral absorption_Homo sapiens_hsa04978	0.19823703
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.17712514
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.17474239
90	Cocaine addiction_Homo sapiens_hsa05030	0.15994183
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.14892160
92	Salivary secretion_Homo sapiens_hsa04970	0.12609793
93	Circadian entrainment_Homo sapiens_hsa04713	0.12047885
94	Taste transduction_Homo sapiens_hsa04742	0.11497624
95	p53 signaling pathway_Homo sapiens_hsa04115	0.10891965
96	Insulin secretion_Homo sapiens_hsa04911	0.10514468
97	Cell cycle_Homo sapiens_hsa04110	0.09721910
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.09216943
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.09027413
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.08097196

GMPSP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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