GNA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)5.38107005
2intestinal cholesterol absorption (GO:0030299)4.99562311
3angiotensin maturation (GO:0002003)4.57356743
4postsynaptic membrane organization (GO:0001941)4.06060457
5regulation of guanylate cyclase activity (GO:0031282)3.92500779
6desmosome organization (GO:0002934)3.80706697
7vitamin A metabolic process (GO:0006776)3.70033168
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.64702203
9cell differentiation involved in metanephros development (GO:0072202)3.58677736
10positive regulation of pseudopodium assembly (GO:0031274)3.55867416
11GDP-mannose metabolic process (GO:0019673)3.51651775
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.51306746
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.42687325
14renal system process involved in regulation of blood volume (GO:0001977)3.42047884
15facial nerve structural organization (GO:0021612)3.34698670
16respiratory chain complex IV assembly (GO:0008535)3.34391525
17protein retention in ER lumen (GO:0006621)3.33936932
18bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33622470
19regulation of pseudopodium assembly (GO:0031272)3.33563633
20epithelial cell-cell adhesion (GO:0090136)3.26633285
21sodium ion export (GO:0071436)3.25705918
22peptide hormone processing (GO:0016486)3.21734865
23hemidesmosome assembly (GO:0031581)3.20545495
24glandular epithelial cell differentiation (GO:0002067)3.20395879
25renal filtration (GO:0097205)3.20027906
26fructose metabolic process (GO:0006000)3.15912637
27Golgi transport vesicle coating (GO:0048200)3.14815444
28COPI coating of Golgi vesicle (GO:0048205)3.14815444
29negative regulation of fatty acid transport (GO:2000192)3.11435816
30regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.10700001
31negative regulation of hormone metabolic process (GO:0032351)3.09584002
32negative regulation of hormone biosynthetic process (GO:0032353)3.09584002
33regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06240608
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99960216
35regulation of glucocorticoid metabolic process (GO:0031943)2.95405457
36regulation of bile acid biosynthetic process (GO:0070857)2.94181693
37actin filament depolymerization (GO:0030042)2.92571906
38hormone catabolic process (GO:0042447)2.91455248
39glomerular filtration (GO:0003094)2.90619987
40lipoprotein transport (GO:0042953)2.90559124
41glucose 6-phosphate metabolic process (GO:0051156)2.89632503
42positive regulation of guanylate cyclase activity (GO:0031284)2.84755958
43regulation of cholesterol homeostasis (GO:2000188)2.83803956
44proline biosynthetic process (GO:0006561)2.82999122
45epoxygenase P450 pathway (GO:0019373)2.81818093
46regulation of axon extension involved in axon guidance (GO:0048841)2.81155893
473-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80988697
48purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80988697
49regulation of early endosome to late endosome transport (GO:2000641)2.79538530
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.78792071
51barbed-end actin filament capping (GO:0051016)2.77535590
52positive regulation of fatty acid beta-oxidation (GO:0032000)2.77518558
53regulation of extracellular matrix disassembly (GO:0010715)2.75500986
54renal absorption (GO:0070293)2.73449182
55cell-substrate junction assembly (GO:0007044)2.72339083
56response to hepatocyte growth factor (GO:0035728)2.71924657
57cellular response to hepatocyte growth factor stimulus (GO:0035729)2.71924657
58diacylglycerol metabolic process (GO:0046339)2.71602917
59adherens junction assembly (GO:0034333)2.71530308
60neuronal action potential propagation (GO:0019227)2.70311370
61virion attachment to host cell (GO:0019062)2.70252739
62adhesion of symbiont to host cell (GO:0044650)2.70252739
63urea cycle (GO:0000050)2.70080131
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69695301
65receptor guanylyl cyclase signaling pathway (GO:0007168)2.68456786
66metanephric tubule development (GO:0072170)2.68250440
67metanephric nephron tubule development (GO:0072234)2.68250440
68regulation of male gonad development (GO:2000018)2.65480885
69receptor recycling (GO:0001881)2.65215628
70mesonephros development (GO:0001823)2.63697177
71mesenchymal cell differentiation involved in renal system development (GO:2001012)2.63585903
72mesenchymal cell differentiation involved in kidney development (GO:0072161)2.63585903
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62534095
74glutamine family amino acid biosynthetic process (GO:0009084)2.61989298
75skin morphogenesis (GO:0043589)2.60477566
76presynaptic membrane assembly (GO:0097105)2.59743836
77fat-soluble vitamin biosynthetic process (GO:0042362)2.58978138
78cell communication involved in cardiac conduction (GO:0086065)2.58018293
79endothelium development (GO:0003158)2.57931442
80pattern specification involved in kidney development (GO:0061004)2.57055275
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56247316
82negative regulation of myotube differentiation (GO:0010832)2.54936543
83renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.54575221
84cGMP-mediated signaling (GO:0019934)2.53923262
85nephron tubule formation (GO:0072079)2.53851407
86protein localization to endosome (GO:0036010)2.53528879
87negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53463576
88basement membrane organization (GO:0071711)2.53191547
89negative regulation of keratinocyte proliferation (GO:0010839)2.52407556
90digestive system process (GO:0022600)2.51352061
91cellular potassium ion homeostasis (GO:0030007)2.50729348
92cell-substrate adherens junction assembly (GO:0007045)2.50329820
93focal adhesion assembly (GO:0048041)2.50329820
94negative regulation of catenin import into nucleus (GO:0035414)2.50262076
95urea metabolic process (GO:0019627)2.49604356
96phospholipid scrambling (GO:0017121)2.49158651
97vocalization behavior (GO:0071625)2.48545853
98cerebellar Purkinje cell layer development (GO:0021680)2.48442357
99cytochrome complex assembly (GO:0017004)2.48285599
100cellular response to nutrient (GO:0031670)2.48263663
101androgen biosynthetic process (GO:0006702)2.47638788
102semaphorin-plexin signaling pathway (GO:0071526)2.47027570
103metanephric epithelium development (GO:0072207)2.46689381
104vitamin transmembrane transport (GO:0035461)2.45576253
105nucleoside diphosphate catabolic process (GO:0009134)2.44791204
106actin filament capping (GO:0051693)2.44761400
107regulation of fatty acid beta-oxidation (GO:0031998)2.43877836
108digestion (GO:0007586)2.43808565
109keratan sulfate biosynthetic process (GO:0018146)2.43518069
110cell-cell junction maintenance (GO:0045217)2.43480052
111flavonoid metabolic process (GO:0009812)2.41528828
112regulation of hormone metabolic process (GO:0032350)2.41442093
113protein heterotrimerization (GO:0070208)2.41353661
114activation of Rac GTPase activity (GO:0032863)2.40607158
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40188404
116regulation of axon guidance (GO:1902667)2.39881840
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39624486
118synaptic vesicle docking involved in exocytosis (GO:0016081)2.39556891
119adhesion of symbiont to host (GO:0044406)2.39356929
120regulation of cGMP biosynthetic process (GO:0030826)2.37858561
121metanephric nephron epithelium development (GO:0072243)2.37775816
122proline metabolic process (GO:0006560)2.36938864
123endothelial cell chemotaxis (GO:0035767)2.36495477
124regulation of systemic arterial blood pressure by hormone (GO:0001990)2.36493516
125regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.36493516
126endocrine process (GO:0050886)2.36493516
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.36377649
128branching involved in mammary gland duct morphogenesis (GO:0060444)2.35436668
129negative regulation of actin filament depolymerization (GO:0030835)2.35353346
130cell communication by electrical coupling (GO:0010644)2.35349115
131transcytosis (GO:0045056)2.35191151
132mesenchymal to epithelial transition (GO:0060231)2.35132960
133cranial nerve structural organization (GO:0021604)2.34374325
134regulation of transforming growth factor beta1 production (GO:0032908)2.34120779
135regulation of glucose import in response to insulin stimulus (GO:2001273)2.29966147
136membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.29827360
137nucleoside diphosphate biosynthetic process (GO:0009133)2.29688479
138regulation of cellular respiration (GO:0043457)2.28585073
139sexual reproduction (GO:0019953)2.28263923
140dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.27603239
141dermatan sulfate biosynthetic process (GO:0030208)2.27560597
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27454253
143vascular endothelial growth factor signaling pathway (GO:0038084)2.26896627
144establishment or maintenance of bipolar cell polarity (GO:0061245)2.26459185
145establishment or maintenance of apical/basal cell polarity (GO:0035088)2.26459185
146ventricular cardiac muscle cell action potential (GO:0086005)2.26150362
147midgut development (GO:0007494)2.25913192
148sequestering of extracellular ligand from receptor (GO:0035581)2.24682732
149mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.24472529
150phosphate ion transmembrane transport (GO:0035435)2.24235776
151glomerulus development (GO:0032835)2.24154230
152positive regulation of hormone metabolic process (GO:0032352)2.24022306
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.23723694
154positive regulation of lipid catabolic process (GO:0050996)2.23549595
155drinking behavior (GO:0042756)2.23539666
156very-low-density lipoprotein particle assembly (GO:0034379)2.21901026
157sodium ion homeostasis (GO:0055078)2.20910906
158nitrogen cycle metabolic process (GO:0071941)2.20821842
159cellular response to nitric oxide (GO:0071732)2.20472477
160cranial nerve morphogenesis (GO:0021602)2.20005637
161positive regulation of cellular amine metabolic process (GO:0033240)2.18134033
162mannosylation (GO:0097502)2.17446763
163positive regulation of glycoprotein biosynthetic process (GO:0010560)2.16904806
164endocrine pancreas development (GO:0031018)2.14933630
165dermatan sulfate metabolic process (GO:0030205)2.13515719
166positive regulation of triglyceride metabolic process (GO:0090208)2.13409380
167keratinocyte proliferation (GO:0043616)2.13203412
168nephron epithelium development (GO:0072009)2.12972184
169sulfation (GO:0051923)2.12589186
170peptide catabolic process (GO:0043171)2.10810951
171regulation of systemic arterial blood pressure (GO:0003073)2.10217084
172positive regulation of metanephros development (GO:0072216)2.09931659
173NADH metabolic process (GO:0006734)2.09891671
174central nervous system neuron axonogenesis (GO:0021955)2.08557514
175protein N-linked glycosylation via asparagine (GO:0018279)2.08221741
176protein maturation by protein folding (GO:0022417)2.08055556
177regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.07592292
178positive regulation of glycoprotein metabolic process (GO:1903020)2.06889071
179short-term memory (GO:0007614)2.06772651
180COPII vesicle coating (GO:0048208)2.06366501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23575831
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.65876074
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.06130529
4CDX2_20551321_ChIP-Seq_CACO-2_Human2.85657820
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65814147
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46871721
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46389543
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46389543
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.41483162
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37354693
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31290709
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30189592
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.27380859
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24361405
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20483807
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.20171534
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19236362
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17329195
19ZNF263_19887448_ChIP-Seq_K562_Human2.15516288
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13997277
21CLOCK_20551151_ChIP-Seq_293T_Human2.11151533
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09290615
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04569857
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99528089
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98157646
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92817992
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92338257
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92332584
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91862739
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.90938565
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80103151
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.72752086
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.68994179
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66498739
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64291096
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63904190
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61987015
38SOX2_20726797_ChIP-Seq_SW620_Human1.58935830
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57403526
40GBX2_23144817_ChIP-Seq_PC3_Human1.56744114
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53653404
42CTCF_27219007_Chip-Seq_Bcells_Human1.52779757
43* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48481377
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48229104
45* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47159633
46DROSHA_22980978_ChIP-Seq_HELA_Human1.46894893
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.46095892
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42149998
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40920614
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.38580197
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37784567
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36416146
53CREB1_26743006_Chip-Seq_LNCaP_Human1.35250953
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34731595
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31852642
56TP53_22127205_ChIP-Seq_IMR90_Human1.31675227
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.30664623
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27026941
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24195962
60SMC4_20622854_ChIP-Seq_HELA_Human1.23806952
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.23763641
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23685013
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.22915867
64* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22152348
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20338554
66P68_20966046_ChIP-Seq_HELA_Human1.18355764
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16912651
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.16855743
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.15905304
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.15905304
71TP63_22573176_ChIP-Seq_HFKS_Human1.15790586
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.15524809
73GATA6_25053715_ChIP-Seq_YYC3_Human1.15409274
74ATF3_27146783_Chip-Seq_COLON_Human1.13161369
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12893965
76* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12236224
77KLF5_25053715_ChIP-Seq_YYC3_Human1.11595869
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11561036
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11475388
80* LXR_22292898_ChIP-Seq_THP-1_Human1.11088782
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11069495
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09954137
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09743303
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07669369
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07397494
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07325628
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05643275
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05368280
89KDM2B_26808549_Chip-Seq_DND41_Human1.05106745
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04950617
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04743329
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04716247
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04631632
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.04482113
95RACK7_27058665_Chip-Seq_MCF-7_Human1.04220979
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.03901486
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.02714975
98* REST_21632747_ChIP-Seq_MESCs_Mouse1.02619288
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.01903057
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01051243
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00480804
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99676230
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98391406
104TCF7_22412390_ChIP-Seq_EML_Mouse0.97809722
105* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97455122
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97313669
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97224383
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96616976
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96464841
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95924187
111TP53_18474530_ChIP-ChIP_U2OS_Human0.95639823
112REST_18959480_ChIP-ChIP_MESCs_Mouse0.94889749
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94754846
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.94032699
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93338438
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.93168700
117* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91059981
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90341398
119ZNF274_21170338_ChIP-Seq_K562_Hela0.90326269
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89821373
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.89580420
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88852198
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88835616
124BCAT_22108803_ChIP-Seq_LS180_Human0.88727108
125* GATA4_25053715_ChIP-Seq_YYC3_Human0.86507579
126KDM2B_26808549_Chip-Seq_K562_Human0.84312629
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.83983337
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83934148
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83408866
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83116962
131SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82741603
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82521875
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.82188599
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82113616
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80481752
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.79575288
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.79104868
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79015043
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.78847810
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78579224
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77625204
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.75572097
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.74402789
144* TP53_23651856_ChIP-Seq_MEFs_Mouse0.73827293
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73574113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.16600242
2MP0005360_urolithiasis3.36056481
3MP0002822_catalepsy3.26827837
4MP0003941_abnormal_skin_development2.95357039
5MP0001666_abnormal_nutrient_absorption2.89475296
6MP0004043_abnormal_pH_regulation2.50357013
7MP0002139_abnormal_hepatobiliary_system2.48656763
8MP0000566_synostosis2.37868815
9MP0004270_analgesia2.37463343
10MP0004147_increased_porphyrin_level2.32925288
11MP0003283_abnormal_digestive_organ2.32214605
12MP0005257_abnormal_intraocular_pressure2.29228283
13MP0005084_abnormal_gallbladder_morpholo2.25693788
14MP0010352_gastrointestinal_tract_polyps2.14888434
15MP0000462_abnormal_digestive_system2.04995563
16* MP0009379_abnormal_foot_pigmentation2.01608720
17MP0003385_abnormal_body_wall1.92848190
18MP0001958_emphysema1.91833014
19MP0004272_abnormal_basement_membrane1.90493066
20MP0009780_abnormal_chondrocyte_physiolo1.90132550
21MP0001664_abnormal_digestion1.89648022
22MP0003566_abnormal_cell_adhesion1.86841408
23MP0003879_abnormal_hair_cell1.81117316
24MP0009384_cardiac_valve_regurgitation1.77655321
25MP0005670_abnormal_white_adipose1.76593487
26MP0000751_myopathy1.76112708
27MP0001849_ear_inflammation1.74291326
28MP0004859_abnormal_synaptic_plasticity1.73704856
29* MP0000049_abnormal_middle_ear1.71738029
30MP0005623_abnormal_meninges_morphology1.67657572
31MP0002909_abnormal_adrenal_gland1.65475228
32MP0002089_abnormal_postnatal_growth/wei1.62083995
33MP0002796_impaired_skin_barrier1.61894639
34MP0003279_aneurysm1.60860238
35* MP0000678_abnormal_parathyroid_gland1.58182411
36MP0003329_amyloid_beta_deposits1.57311996
37MP0005085_abnormal_gallbladder_physiolo1.52415787
38MP0005451_abnormal_body_composition1.51698243
39MP0000613_abnormal_salivary_gland1.48357200
40MP0003252_abnormal_bile_duct1.42938613
41MP0004264_abnormal_extraembryonic_tissu1.39531914
42MP0004858_abnormal_nervous_system1.39509535
43MP0003091_abnormal_cell_migration1.38401533
44MP0004019_abnormal_vitamin_homeostasis1.36657840
45MP0000003_abnormal_adipose_tissue1.36036271
46MP0005023_abnormal_wound_healing1.35092215
47MP0008438_abnormal_cutaneous_collagen1.34530947
48MP0002751_abnormal_autonomic_nervous1.33690462
49* MP0001188_hyperpigmentation1.32594962
50MP0000538_abnormal_urinary_bladder1.32024703
51MP0000537_abnormal_urethra_morphology1.28052788
52MP0002837_dystrophic_cardiac_calcinosis1.26961593
53MP0000534_abnormal_ureter_morphology1.23952692
54MP0000013_abnormal_adipose_tissue1.23112129
55MP0002877_abnormal_melanocyte_morpholog1.22836252
56MP0009250_abnormal_appendicular_skeleto1.22679151
57MP0000467_abnormal_esophagus_morphology1.22354309
58MP0001944_abnormal_pancreas_morphology1.21836838
59MP0008875_abnormal_xenobiotic_pharmacok1.21676961
60MP0005501_abnormal_skin_physiology1.20218183
61MP0004782_abnormal_surfactant_physiolog1.19971430
62MP0003646_muscle_fatigue1.19257196
63MP0000762_abnormal_tongue_morphology1.18941418
64MP0003950_abnormal_plasma_membrane1.16697387
65MP0010329_abnormal_lipoprotein_level1.16217794
66MP0003868_abnormal_feces_composition1.15456645
67MP0002060_abnormal_skin_morphology1.11980975
68MP0003880_abnormal_central_pattern1.11963222
69MP0000477_abnormal_intestine_morphology1.11575896
70MP0003635_abnormal_synaptic_transmissio1.10689065
71MP0003942_abnormal_urinary_system1.10286913
72MP0003119_abnormal_digestive_system1.10182950
73MP0002735_abnormal_chemical_nociception1.08683470
74MP0005503_abnormal_tendon_morphology1.08547697
75MP0005375_adipose_tissue_phenotype1.06601084
76MP0005666_abnormal_adipose_tissue1.06417292
77MP0010386_abnormal_urinary_bladder1.03530550
78MP0003453_abnormal_keratinocyte_physiol1.03285028
79MP0001270_distended_abdomen1.02596022
80MP0000631_abnormal_neuroendocrine_gland1.02058905
81MP0010368_abnormal_lymphatic_system1.00460939
82MP0000749_muscle_degeneration1.00437277
83MP0005076_abnormal_cell_differentiation1.00158644
84MP0010030_abnormal_orbit_morphology0.99888627
85MP0005381_digestive/alimentary_phenotyp0.99056550
86MP0000733_abnormal_muscle_development0.98373294
87MP0005167_abnormal_blood-brain_barrier0.97623981
88MP0006138_congestive_heart_failure0.96804837
89MP0000579_abnormal_nail_morphology0.96782795
90MP0005508_abnormal_skeleton_morphology0.96375175
91* MP0000230_abnormal_systemic_arterial0.94832760
92MP0002295_abnormal_pulmonary_circulatio0.94633488
93MP0003183_abnormal_peptide_metabolism0.92900464
94MP0001663_abnormal_digestive_system0.90424599
95MP0002557_abnormal_social/conspecific_i0.90211606
96MP0003866_abnormal_defecation0.89733057
97MP0000747_muscle_weakness0.89671682
98MP0005165_increased_susceptibility_to0.88936916
99MP0002733_abnormal_thermal_nociception0.87341812
100MP0000767_abnormal_smooth_muscle0.86706452
101* MP0009643_abnormal_urine_homeostasis0.84394486
102MP0001177_atelectasis0.83740820
103MP0002971_abnormal_brown_adipose0.83631911
104MP0005448_abnormal_energy_balance0.83404118
105MP0000372_irregular_coat_pigmentation0.83040712
106MP0005058_abnormal_lysosome_morphology0.82872346
107MP0005365_abnormal_bile_salt0.82191137
108MP0010155_abnormal_intestine_physiology0.81718609
109MP0009697_abnormal_copulation0.81676605
110MP0005330_cardiomyopathy0.81490902
111MP0003136_yellow_coat_color0.81039514
112MP0001756_abnormal_urination0.80684896
113MP0003191_abnormal_cellular_cholesterol0.80251641
114* MP0002249_abnormal_larynx_morphology0.79835297
115* MP0001765_abnormal_ion_homeostasis0.79687444
116MP0001348_abnormal_lacrimal_gland0.78791016
117* MP0002177_abnormal_outer_ear0.78719172
118* MP0000681_abnormal_thyroid_gland0.78363078
119MP0003878_abnormal_ear_physiology0.78303502
120MP0005377_hearing/vestibular/ear_phenot0.78303502
121* MP0002734_abnormal_mechanical_nocicepti0.78258392
122MP0001968_abnormal_touch/_nociception0.78055344
123MP0006054_spinal_hemorrhage0.77437641
124MP0002160_abnormal_reproductive_system0.75070422
125MP0006276_abnormal_autonomic_nervous0.74810899
126MP0008569_lethality_at_weaning0.73298684
127* MP0002896_abnormal_bone_mineralization0.72851701
128MP0005332_abnormal_amino_acid0.72808163
129MP0000759_abnormal_skeletal_muscle0.72630160
130MP0000163_abnormal_cartilage_morphology0.71916914
131MP0003122_maternal_imprinting0.71654220
132MP0004185_abnormal_adipocyte_glucose0.71402554
133MP0004087_abnormal_muscle_fiber0.71301114
134MP0000490_abnormal_crypts_of0.70942143
135MP0004085_abnormal_heartbeat0.70495433
136MP0002098_abnormal_vibrissa_morphology0.68784911
137MP0003828_pulmonary_edema0.68520498
138MP0006292_abnormal_olfactory_placode0.68193270
139MP0005275_abnormal_skin_tensile0.67704092
140MP0003959_abnormal_lean_body0.67248817
141MP0001919_abnormal_reproductive_system0.67037863
142MP0010234_abnormal_vibrissa_follicle0.66701873
143MP0009840_abnormal_foam_cell0.66619311
144MP0002184_abnormal_innervation0.66340119
145MP0002108_abnormal_muscle_morphology0.64192255
146MP0001216_abnormal_epidermal_layer0.63912043
147MP0001879_abnormal_lymphatic_vessel0.62978677
148MP0003045_fibrosis0.62874033
149MP0001299_abnormal_eye_distance/0.62085905
150MP0010771_integument_phenotype0.60850814
151MP0002932_abnormal_joint_morphology0.56854602

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.16485308
2Reduced antithrombin III activity (HP:0001976)4.81957687
3Ileus (HP:0002595)4.65545788
4Abnormal protein glycosylation (HP:0012346)3.94207917
5Abnormal glycosylation (HP:0012345)3.94207917
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.94207917
7Abnormal protein N-linked glycosylation (HP:0012347)3.94207917
8Right ventricular cardiomyopathy (HP:0011663)3.62912651
9Aplasia/hypoplasia of the uterus (HP:0008684)3.50858471
10Late onset (HP:0003584)3.35385676
11Thin bony cortex (HP:0002753)3.12676111
12Obstructive sleep apnea (HP:0002870)3.07642502
13Type 1 muscle fiber predominance (HP:0003803)2.95074560
14Spinal rigidity (HP:0003306)2.92924681
15Shallow orbits (HP:0000586)2.92311291
16Hepatic necrosis (HP:0002605)2.89963149
17Malnutrition (HP:0004395)2.86305651
18Cerebral aneurysm (HP:0004944)2.83464468
19Bradycardia (HP:0001662)2.80488047
20Hyperactive renin-angiotensin system (HP:0000841)2.75869083
21Vascular tortuosity (HP:0004948)2.75504220
22Upper limb amyotrophy (HP:0009129)2.72723736
23Distal upper limb amyotrophy (HP:0007149)2.72723736
24Popliteal pterygium (HP:0009756)2.72459552
25Increased connective tissue (HP:0009025)2.71488474
26Distal lower limb amyotrophy (HP:0008944)2.71166545
27Flat acetabular roof (HP:0003180)2.70440770
28Abnormal sex determination (HP:0012244)2.69757825
29Sex reversal (HP:0012245)2.69757825
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67761606
31Aortic dissection (HP:0002647)2.66785814
32Aortic aneurysm (HP:0004942)2.65046176
33Neonatal short-limb short stature (HP:0008921)2.64700286
34Arterial tortuosity (HP:0005116)2.63083442
35Split foot (HP:0001839)2.62622236
36Glycosuria (HP:0003076)2.58449404
37Abnormality of urine glucose concentration (HP:0011016)2.58449404
38Hypoplasia of the uterus (HP:0000013)2.55578039
39Broad metatarsal (HP:0001783)2.54879319
40Distal lower limb muscle weakness (HP:0009053)2.54521625
41Hypothermia (HP:0002045)2.54459096
42Congenital sensorineural hearing impairment (HP:0008527)2.54190994
43Hepatocellular necrosis (HP:0001404)2.52646915
44Bladder diverticulum (HP:0000015)2.52581307
45Hypoglycemic coma (HP:0001325)2.52432958
46Ankle contracture (HP:0006466)2.50805243
47Abdominal distention (HP:0003270)2.48965856
48Unilateral renal agenesis (HP:0000122)2.47518093
49Mildly elevated creatine phosphokinase (HP:0008180)2.45096300
50Hyperglycinuria (HP:0003108)2.43133883
51Cervical subluxation (HP:0003308)2.42359645
52Wormian bones (HP:0002645)2.42357959
53Polygenic inheritance (HP:0010982)2.40872509
54Cortical visual impairment (HP:0100704)2.39123043
55Cutaneous finger syndactyly (HP:0010554)2.36519376
56Hyperacusis (HP:0010780)2.35941189
57Stridor (HP:0010307)2.34403524
58Myokymia (HP:0002411)2.30143786
59Ulnar bowing (HP:0003031)2.28909624
60Achilles tendon contracture (HP:0001771)2.28727676
61Vertebral compression fractures (HP:0002953)2.26902678
62Mesangial abnormality (HP:0001966)2.26670768
63Spinal cord compression (HP:0002176)2.22417657
64Decreased circulating renin level (HP:0003351)2.22340884
65Myopathic facies (HP:0002058)2.20277646
66Increased variability in muscle fiber diameter (HP:0003557)2.18607879
67Abnormality of the vitamin B12 metabolism (HP:0004341)2.18549833
68Hyperphosphaturia (HP:0003109)2.17923480
69Generalized aminoaciduria (HP:0002909)2.17546894
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16966634
71Lower limb amyotrophy (HP:0007210)2.16121227
72Abnormality of vitamin B metabolism (HP:0004340)2.15899678
73* Hyperparathyroidism (HP:0000843)2.13336185
74Hemorrhage of the eye (HP:0011885)2.12900565
75Abnormality of carpal bone ossification (HP:0006257)2.09657194
76Prolonged QT interval (HP:0001657)2.09507441
77Aneurysm (HP:0002617)2.09205021
78Protrusio acetabuli (HP:0003179)2.08954368
79Abnormality of the Achilles tendon (HP:0005109)2.08840593
80Broad face (HP:0000283)2.08333493
81Syncope (HP:0001279)2.06983589
82Hyperaldosteronism (HP:0000859)2.06622067
83Genu recurvatum (HP:0002816)2.06376183
84Palpitations (HP:0001962)2.05660962
85Hypoventilation (HP:0002791)2.05580412
86Short nail (HP:0001799)2.02952836
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02522422
88Bronchomalacia (HP:0002780)2.02210903
89Hyperextensible skin (HP:0000974)2.02198185
90Symptomatic seizures (HP:0011145)2.02164201
91Blue sclerae (HP:0000592)2.01812231
92Knee flexion contracture (HP:0006380)2.00951296
93Abnormality of calcium-phosphate metabolism (HP:0100530)1.99993601
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.99523234
95Osteolytic defects of the hand bones (HP:0009699)1.97918249
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.97918249
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96489916
98Mitral regurgitation (HP:0001653)1.95619276
99Abnormal ossification of hand bones (HP:0005921)1.95362549
100Metabolic alkalosis (HP:0200114)1.94688547
101Cutaneous syndactyly (HP:0012725)1.94584039
102Abnormality of the aortic arch (HP:0012303)1.94204792
103Agitation (HP:0000713)1.94087717
104Annular pancreas (HP:0001734)1.93570888
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.93333792
106Abnormality of skeletal muscle fiber size (HP:0012084)1.93037568
107Ketoacidosis (HP:0001993)1.92437389
108Gastrointestinal dysmotility (HP:0002579)1.92394488
109Hand muscle atrophy (HP:0009130)1.90963090
110Disproportionate tall stature (HP:0001519)1.90826348
111Abnormality of proline metabolism (HP:0010907)1.90764772
112Hydroxyprolinuria (HP:0003080)1.90764772
113Focal segmental glomerulosclerosis (HP:0000097)1.90403314
114Confusion (HP:0001289)1.90234458
115Pterygium (HP:0001059)1.90198462
116Fat malabsorption (HP:0002630)1.89449102
117Sleep apnea (HP:0010535)1.89273875
118Bundle branch block (HP:0011710)1.87198970
119Abnormal urine phosphate concentration (HP:0012599)1.87023634
120Abnormality of vitamin metabolism (HP:0100508)1.85404540
121Abnormality of chloride homeostasis (HP:0011422)1.85243465
122Soft skin (HP:0000977)1.85072288
123Proximal tubulopathy (HP:0000114)1.83495368
124Round ear (HP:0100830)1.83167119
125Nonprogressive disorder (HP:0003680)1.82944459
126Abnormality of renin-angiotensin system (HP:0000847)1.82675993
127True hermaphroditism (HP:0010459)1.82551963
128Abnormality of the distal phalanges of the toes (HP:0010182)1.81470401
129Growth hormone excess (HP:0000845)1.81186577
130Thyroid-stimulating hormone excess (HP:0002925)1.80536770
131Difficulty climbing stairs (HP:0003551)1.80526962
132Renal Fanconi syndrome (HP:0001994)1.79724116
133Wide cranial sutures (HP:0010537)1.79287070
134Hypobetalipoproteinemia (HP:0003563)1.79052476
135Tibial bowing (HP:0002982)1.78317273
136Coxa vara (HP:0002812)1.77589611
137Xanthomatosis (HP:0000991)1.77343681
138Congenital glaucoma (HP:0001087)1.76755507
139Hypokalemia (HP:0002900)1.76327188
140Adrenal overactivity (HP:0002717)1.75341741
141Mitral valve prolapse (HP:0001634)1.74767205
142Insulin resistance (HP:0000855)1.74120209
143Atrophic scars (HP:0001075)1.73650758
144Abnormality of dentin (HP:0010299)1.73281461
145Hyperinsulinemic hypoglycemia (HP:0000825)1.73266352
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72882238
147Dicarboxylic aciduria (HP:0003215)1.72882238
148Hypoglycemic seizures (HP:0002173)1.72548706
149Goiter (HP:0000853)1.72425515
150Hoarse voice (HP:0001609)1.72150591
151Fragile skin (HP:0001030)1.71876009
152Cardiovascular calcification (HP:0011915)1.71558441
153Exercise-induced myalgia (HP:0003738)1.70842221
154Neonatal death (HP:0003811)1.70321395
155Acanthosis nigricans (HP:0000956)1.70123904
156Dilatation of the ascending aorta (HP:0005111)1.69550778
157Ventricular fibrillation (HP:0001663)1.67551337
158Follicular hyperkeratosis (HP:0007502)1.67038562
159Turricephaly (HP:0000262)1.65104207
160Conjugated hyperbilirubinemia (HP:0002908)1.65059977
161Abnormality of complement system (HP:0005339)1.64086042
162Germ cell neoplasia (HP:0100728)1.63517920
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63168670
164Systemic lupus erythematosus (HP:0002725)1.63163557
165Widely patent fontanelles and sutures (HP:0004492)1.63027363
166Elbow flexion contracture (HP:0002987)1.62056936
167Joint laxity (HP:0001388)1.61616860
168Hypercortisolism (HP:0001578)1.60319958
169Skin nodule (HP:0200036)1.60214916
170Abnormality of the nasal mucosa (HP:0000433)1.60047201
171Visual hallucinations (HP:0002367)1.59165137
172Abnormality of the acetabulum (HP:0003170)1.59072121
173Rectal prolapse (HP:0002035)1.58839374
174Abnormality of glycine metabolism (HP:0010895)1.58746128
175Abnormality of serine family amino acid metabolism (HP:0010894)1.58746128
176Asymmetric growth (HP:0100555)1.58219594
177Neurofibrillary tangles (HP:0002185)1.57892512
178Premature rupture of membranes (HP:0001788)1.57827356
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.56107811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.98232487
2EIF2AK33.17936676
3CASK3.10287566
4LMTK22.92998772
5NLK2.57033439
6FRK2.36279173
7EPHB22.29609296
8TTN2.23972283
9SIK12.17224708
10PRKG22.16520810
11ICK2.12377412
12MYLK2.09923580
13MAP2K22.08191471
14MUSK2.07266863
15EEF2K2.06516468
16BCKDK2.05637629
17SMG12.04073508
18NTRK31.97963336
19CAMKK21.92250382
20FER1.89737659
21MST1R1.86724307
22MAP3K21.85417191
23MAP2K71.74603989
24WNK41.65679218
25NME11.60236060
26AKT31.58681300
27MARK11.54292956
28MET1.45577516
29CAMKK11.43239984
30FGFR41.37076569
31EPHA41.35138904
32MKNK21.33766743
33RIPK11.29060887
34EPHB11.29032165
35NTRK11.28409377
36PAK41.26719921
37MAP3K101.25393407
38INSRR1.23359650
39PKN21.20121330
40DDR21.16725777
41CAMK11.11110538
42MAPK151.11091343
43KSR21.08413826
44TRIB31.03546213
45PHKG11.03328146
46PHKG21.03328146
47PIK3CA1.02924341
48MAP3K11.01875642
49ARAF1.01064320
50PAK31.00880084
51IRAK30.97148583
52TIE10.94068553
53EPHA20.93363922
54ACVR1B0.93354270
55MAPKAPK30.92115498
56PDPK10.91350497
57TAOK10.90750301
58PRKCI0.89410199
59ROCK10.88725141
60MTOR0.88550619
61PAK60.87559762
62PRKD30.86731309
63PTK2B0.86480203
64EIF2AK20.85544549
65TESK10.84151138
66STK380.83241818
67MAP2K10.81301620
68ABL20.78409599
69LATS20.77858259
70PINK10.76946308
71CAMK2D0.76530609
72PIM20.75810591
73DMPK0.75537284
74LIMK10.73017761
75MINK10.72709654
76DAPK20.71005416
77CDC42BPA0.70413873
78CDK120.70285698
79ERN10.70089453
80PTK20.69778863
81CAMK2B0.69449237
82MAP3K60.68650103
83PDGFRA0.67176839
84MAP3K70.66608302
85ROCK20.63092572
86ERBB20.63090749
87MAP3K90.62573823
88TESK20.62447008
89STK160.61418388
90PRPF4B0.60740308
91CAMK40.60368201
92FES0.60346499
93MAP2K60.59509145
94LATS10.58990586
95BRAF0.58980398
96ZAK0.57940338
97CDK190.57370433
98UHMK10.57349206
99CAMK2A0.57038552
100MAP3K110.56625661
101PDGFRB0.56095367
102MAPK110.55623740
103NEK60.54212937
104CDK50.53647361
105RET0.53271282
106TYRO30.51745487
107MST40.51080662
108PRKD20.50933857
109DYRK1B0.50603921
110PTK60.50245980
111CAMK2G0.48550323
112GRK10.47865532
113PAK20.47454037
114DAPK30.47191185
115MAP3K80.47154035
116BMX0.45656201
117MARK20.43107703
118MAP3K30.43006847
119PRKCG0.42144350
120TGFBR20.41670545
121SRPK10.41493624
122AKT20.41449162
123MAPK130.40962216
124DYRK20.40222136
125LRRK20.38950399
126PRKCE0.38081939
127SCYL20.37544575
128RPS6KA20.37359523
129SRC0.36421528
130SGK4940.35682963
131SGK2230.35682963
132MOS0.35417007
133STK390.35229856
134CDK11A0.34617330
135ERBB40.34536582
136RPS6KL10.34200906
137RPS6KC10.34200906
138CDK150.33582548
139KDR0.33423012
140MAP3K120.33396553
141PRKAA20.33250815
142TLK10.31763890
143ILK0.31430806
144TAOK20.28571075

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.68455861
2Fat digestion and absorption_Homo sapiens_hsa049753.45125093
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.11870488
4Sulfur metabolism_Homo sapiens_hsa009202.82963267
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54796884
6Renin-angiotensin system_Homo sapiens_hsa046142.52167118
7Arginine biosynthesis_Homo sapiens_hsa002202.30600679
8Vitamin digestion and absorption_Homo sapiens_hsa049772.22913429
9Galactose metabolism_Homo sapiens_hsa000522.11969191
10Mineral absorption_Homo sapiens_hsa049782.07863349
11N-Glycan biosynthesis_Homo sapiens_hsa005101.99185101
12Protein export_Homo sapiens_hsa030601.98107750
13Protein digestion and absorption_Homo sapiens_hsa049741.92905211
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92699193
15Thyroid cancer_Homo sapiens_hsa052161.77330358
16Folate biosynthesis_Homo sapiens_hsa007901.75575769
17Starch and sucrose metabolism_Homo sapiens_hsa005001.74494120
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54811707
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38627265
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37371360
21Fructose and mannose metabolism_Homo sapiens_hsa000511.37097118
22Bile secretion_Homo sapiens_hsa049761.36204236
23* Insulin secretion_Homo sapiens_hsa049111.35080696
24Phenylalanine metabolism_Homo sapiens_hsa003601.34422393
25ECM-receptor interaction_Homo sapiens_hsa045121.29902689
26Sphingolipid metabolism_Homo sapiens_hsa006001.23937023
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16840923
28Glutathione metabolism_Homo sapiens_hsa004801.15634920
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15600454
30Focal adhesion_Homo sapiens_hsa045101.12363498
31Thyroid hormone synthesis_Homo sapiens_hsa049181.11852692
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11801710
33Cocaine addiction_Homo sapiens_hsa050301.09346891
34Amphetamine addiction_Homo sapiens_hsa050311.07847325
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06054189
36Histidine metabolism_Homo sapiens_hsa003400.99208137
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98662169
38Pancreatic secretion_Homo sapiens_hsa049720.98451894
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.96573835
40Prion diseases_Homo sapiens_hsa050200.96057613
41Arginine and proline metabolism_Homo sapiens_hsa003300.94990235
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94683435
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92836489
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92641202
45Oxidative phosphorylation_Homo sapiens_hsa001900.91471465
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91118828
47Parkinsons disease_Homo sapiens_hsa050120.90583872
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89763493
49Circadian entrainment_Homo sapiens_hsa047130.89057370
50Melanogenesis_Homo sapiens_hsa049160.88508888
51* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88313046
52Vibrio cholerae infection_Homo sapiens_hsa051100.88079725
53Tight junction_Homo sapiens_hsa045300.87748346
54Tryptophan metabolism_Homo sapiens_hsa003800.87687935
55Glycerolipid metabolism_Homo sapiens_hsa005610.87687111
56Other glycan degradation_Homo sapiens_hsa005110.87491707
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87275602
58Fatty acid degradation_Homo sapiens_hsa000710.86240659
59Arachidonic acid metabolism_Homo sapiens_hsa005900.86225985
60Sulfur relay system_Homo sapiens_hsa041220.85121268
61Dilated cardiomyopathy_Homo sapiens_hsa054140.83408597
62Caffeine metabolism_Homo sapiens_hsa002320.83407315
63Adherens junction_Homo sapiens_hsa045200.81063252
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80856185
65Gastric acid secretion_Homo sapiens_hsa049710.80024923
66Pentose phosphate pathway_Homo sapiens_hsa000300.79427942
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78854866
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78165679
69AMPK signaling pathway_Homo sapiens_hsa041520.77363700
70Synaptic vesicle cycle_Homo sapiens_hsa047210.77313253
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76778749
72Alzheimers disease_Homo sapiens_hsa050100.74371358
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74324991
74Cardiac muscle contraction_Homo sapiens_hsa042600.72233100
75Salivary secretion_Homo sapiens_hsa049700.70349931
76Fatty acid elongation_Homo sapiens_hsa000620.70266019
77Glucagon signaling pathway_Homo sapiens_hsa049220.70147498
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.69952206
79PPAR signaling pathway_Homo sapiens_hsa033200.69816550
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.69640580
81Biosynthesis of amino acids_Homo sapiens_hsa012300.69636442
82Estrogen signaling pathway_Homo sapiens_hsa049150.68408441
83Basal cell carcinoma_Homo sapiens_hsa052170.68371476
84Bladder cancer_Homo sapiens_hsa052190.67473030
85Dopaminergic synapse_Homo sapiens_hsa047280.66960949
86Butanoate metabolism_Homo sapiens_hsa006500.66810704
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.66697228
88Notch signaling pathway_Homo sapiens_hsa043300.66042006
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64998965
90Proteoglycans in cancer_Homo sapiens_hsa052050.63689138
91Vitamin B6 metabolism_Homo sapiens_hsa007500.63631432
92* Cholinergic synapse_Homo sapiens_hsa047250.63468820
93Insulin resistance_Homo sapiens_hsa049310.63386915
94Tyrosine metabolism_Homo sapiens_hsa003500.62991108
95* GnRH signaling pathway_Homo sapiens_hsa049120.62768806
96Insulin signaling pathway_Homo sapiens_hsa049100.62507884
97Serotonergic synapse_Homo sapiens_hsa047260.61513328
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61002536
99ABC transporters_Homo sapiens_hsa020100.58928114
100Glutamatergic synapse_Homo sapiens_hsa047240.58480398
101Wnt signaling pathway_Homo sapiens_hsa043100.57995375
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57355799
103* Amoebiasis_Homo sapiens_hsa051460.57292511
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.56825661
105Long-term potentiation_Homo sapiens_hsa047200.56503701
106Axon guidance_Homo sapiens_hsa043600.55365226
107beta-Alanine metabolism_Homo sapiens_hsa004100.55252504
108Renin secretion_Homo sapiens_hsa049240.54960726
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.54172872
110Taste transduction_Homo sapiens_hsa047420.52458682
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.51684544
112* Gap junction_Homo sapiens_hsa045400.51677315
113Fatty acid biosynthesis_Homo sapiens_hsa000610.51630792
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51370176
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51287217
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51084824
117VEGF signaling pathway_Homo sapiens_hsa043700.51083072
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50828236
119Hippo signaling pathway_Homo sapiens_hsa043900.48752119
120Type II diabetes mellitus_Homo sapiens_hsa049300.48387826
121Chemical carcinogenesis_Homo sapiens_hsa052040.47593936
122Metabolic pathways_Homo sapiens_hsa011000.47178869
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46703199
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45370210
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45201744
126Huntingtons disease_Homo sapiens_hsa050160.44845960
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.44268681
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44258825
129Chronic myeloid leukemia_Homo sapiens_hsa052200.43836463
130Glioma_Homo sapiens_hsa052140.43462268
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42631340
132Fatty acid metabolism_Homo sapiens_hsa012120.41194828
133Carbon metabolism_Homo sapiens_hsa012000.40894718
134Linoleic acid metabolism_Homo sapiens_hsa005910.40467069
135* Long-term depression_Homo sapiens_hsa047300.39843771
136Retinol metabolism_Homo sapiens_hsa008300.38571646
137GABAergic synapse_Homo sapiens_hsa047270.38475565
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38283057
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37754454
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37643531

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