GNA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.98713930
2central nervous system myelination (GO:0022010)5.98713930
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37339746
4L-phenylalanine catabolic process (GO:0006559)5.37339746
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.93808872
6L-phenylalanine metabolic process (GO:0006558)4.93808872
7fatty acid elongation (GO:0030497)4.64606569
8alpha-linolenic acid metabolic process (GO:0036109)4.44844320
9regulation of early endosome to late endosome transport (GO:2000641)4.13363490
10ensheathment of neurons (GO:0007272)4.04735701
11axon ensheathment (GO:0008366)4.04735701
12myelination (GO:0042552)4.00522916
13myelin maintenance (GO:0043217)3.96359336
14aromatic amino acid family catabolic process (GO:0009074)3.90281941
15barbed-end actin filament capping (GO:0051016)3.86829536
16creatine metabolic process (GO:0006600)3.81356420
17glyoxylate metabolic process (GO:0046487)3.79441745
18stress fiber assembly (GO:0043149)3.76492372
19response to methylmercury (GO:0051597)3.61285817
20very long-chain fatty acid metabolic process (GO:0000038)3.58848098
21bile acid biosynthetic process (GO:0006699)3.57343256
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.50104486
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.49795761
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44846318
25skin morphogenesis (GO:0043589)3.42484398
26Golgi transport vesicle coating (GO:0048200)3.33840349
27COPI coating of Golgi vesicle (GO:0048205)3.33840349
28negative regulation of erythrocyte differentiation (GO:0045647)3.33831583
29aspartate family amino acid catabolic process (GO:0009068)3.32487007
30epithelial cell-cell adhesion (GO:0090136)3.31869576
31adherens junction assembly (GO:0034333)3.30547613
32acetyl-CoA metabolic process (GO:0006084)3.29587516
33semaphorin-plexin signaling pathway (GO:0071526)3.27729495
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.24915667
35heme transport (GO:0015886)3.23239155
36fatty-acyl-CoA biosynthetic process (GO:0046949)3.22799898
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.22520853
38peptidyl-glutamic acid carboxylation (GO:0017187)3.22164940
39protein carboxylation (GO:0018214)3.22164940
40pinocytosis (GO:0006907)3.20383469
41protein retention in ER lumen (GO:0006621)3.20153963
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19748050
43apoptotic cell clearance (GO:0043277)3.19424529
44short-chain fatty acid metabolic process (GO:0046459)3.18522400
45plasma lipoprotein particle clearance (GO:0034381)3.17385073
46endodermal cell differentiation (GO:0035987)3.14942883
47long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.13850861
48regulation of triglyceride catabolic process (GO:0010896)3.09601299
49bile acid metabolic process (GO:0008206)3.08285958
50focal adhesion assembly (GO:0048041)3.07571666
51cell-substrate adherens junction assembly (GO:0007045)3.07571666
52cellular ketone body metabolic process (GO:0046950)3.06211914
53regulation of extracellular matrix disassembly (GO:0010715)3.05913732
54fatty acid beta-oxidation (GO:0006635)3.05578810
55acyl-CoA biosynthetic process (GO:0071616)3.05479924
56thioester biosynthetic process (GO:0035384)3.05479924
57negative regulation of fibrinolysis (GO:0051918)3.04018337
58coenzyme catabolic process (GO:0009109)3.03996770
59positive regulation of extracellular matrix organization (GO:1903055)3.01650412
60cell-substrate junction assembly (GO:0007044)3.00608562
61ethanol oxidation (GO:0006069)3.00028799
62cell adhesion mediated by integrin (GO:0033627)2.99469211
63lysine metabolic process (GO:0006553)2.97857006
64lysine catabolic process (GO:0006554)2.97857006
65regulation of lipoprotein metabolic process (GO:0050746)2.97540795
66kynurenine metabolic process (GO:0070189)2.96958798
67cysteine metabolic process (GO:0006534)2.96681640
68response to mercury ion (GO:0046689)2.94738582
69fatty-acyl-CoA metabolic process (GO:0035337)2.94433043
70cholesterol biosynthetic process (GO:0006695)2.93889983
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92987128
72cortical actin cytoskeleton organization (GO:0030866)2.92697605
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.91438816
74basement membrane organization (GO:0071711)2.90900414
75fatty acid catabolic process (GO:0009062)2.90414678
76regulation of cholesterol metabolic process (GO:0090181)2.89671248
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.88307877
78positive regulation of blood vessel endothelial cell migration (GO:0043536)2.88197719
79high-density lipoprotein particle remodeling (GO:0034375)2.86307018
80complement activation, alternative pathway (GO:0006957)2.86134349
81sulfur amino acid catabolic process (GO:0000098)2.85157904
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84396702
83negative regulation of protein localization to cell surface (GO:2000009)2.84307844
84glutamate metabolic process (GO:0006536)2.83786552
85positive regulation of fatty acid oxidation (GO:0046321)2.83516208
86protein localization to endosome (GO:0036010)2.82443995
87fatty acid oxidation (GO:0019395)2.81512203
88response to lipoprotein particle (GO:0055094)2.79724133
89tyrosine metabolic process (GO:0006570)2.79407744
90lipid oxidation (GO:0034440)2.77293531
91peptidyl-tyrosine autophosphorylation (GO:0038083)2.76852911
92acyl-CoA metabolic process (GO:0006637)2.76225876
93thioester metabolic process (GO:0035383)2.76225876
94regulation of cholesterol biosynthetic process (GO:0045540)2.76189558
95negative regulation of adherens junction organization (GO:1903392)2.74498167
96negative regulation of focal adhesion assembly (GO:0051895)2.74498167
97negative regulation of cell junction assembly (GO:1901889)2.74498167
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.74169631
99monocarboxylic acid catabolic process (GO:0072329)2.72778486
100reverse cholesterol transport (GO:0043691)2.72455762
101positive regulation of fatty acid beta-oxidation (GO:0032000)2.72272727
102cholesterol efflux (GO:0033344)2.71084295
103cell-cell junction maintenance (GO:0045217)2.71046313
104astrocyte development (GO:0014002)2.69943669
105regulation of fibrinolysis (GO:0051917)2.69904789
106dicarboxylic acid catabolic process (GO:0043649)2.68848271
107alpha-amino acid catabolic process (GO:1901606)2.67721665
108import into cell (GO:0098657)2.67482087
109adenosine receptor signaling pathway (GO:0001973)2.67305569
110chondroitin sulfate biosynthetic process (GO:0030206)2.67208165
111ketone body metabolic process (GO:1902224)2.65302420
112regulation of glucose import in response to insulin stimulus (GO:2001273)2.64758475
113positive regulation of receptor recycling (GO:0001921)2.64297435
114regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64192750
115tryptophan catabolic process (GO:0006569)2.64098923
116indole-containing compound catabolic process (GO:0042436)2.64098923
117indolalkylamine catabolic process (GO:0046218)2.64098923
118regulation of protein activation cascade (GO:2000257)2.64044709
119myelination in peripheral nervous system (GO:0022011)2.63441949
120peripheral nervous system axon ensheathment (GO:0032292)2.63441949
121aromatic amino acid family metabolic process (GO:0009072)2.62811686
122cortical cytoskeleton organization (GO:0030865)2.62556851
123iron coordination entity transport (GO:1901678)2.62202356
124endocytic recycling (GO:0032456)2.62058440
125long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.61713636
126substrate-dependent cell migration (GO:0006929)2.60822578
127glycerophospholipid catabolic process (GO:0046475)2.60296160
128cofactor catabolic process (GO:0051187)2.60082302
129cholesterol homeostasis (GO:0042632)2.60061924
130embryo implantation (GO:0007566)2.59919152
131positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59892096
132cell volume homeostasis (GO:0006884)2.59530305
133sterol biosynthetic process (GO:0016126)2.58593158
134establishment of mitochondrion localization (GO:0051654)2.57807693
135cellular amino acid catabolic process (GO:0009063)2.57302922
136cellular modified amino acid catabolic process (GO:0042219)2.57223600
137modulation by symbiont of host cellular process (GO:0044068)2.56528023
138positive regulation of endothelial cell apoptotic process (GO:2000353)2.56450932
139sterol homeostasis (GO:0055092)2.56382871
140negative regulation of lipase activity (GO:0060192)2.56032302
141triglyceride homeostasis (GO:0070328)2.55807822
142acylglycerol homeostasis (GO:0055090)2.55807822
143regulation of extracellular matrix organization (GO:1903053)2.55333590
144response to laminar fluid shear stress (GO:0034616)2.54250816
145amyloid precursor protein metabolic process (GO:0042982)2.53952461
146amino-acid betaine metabolic process (GO:0006577)2.53498166
147regulation of sequestering of triglyceride (GO:0010889)2.53407723
148cholesterol metabolic process (GO:0008203)2.53166302
149plasma lipoprotein particle remodeling (GO:0034369)2.52958562
150protein-lipid complex remodeling (GO:0034368)2.52958562
151macromolecular complex remodeling (GO:0034367)2.52958562
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51496977
153low-density lipoprotein particle clearance (GO:0034383)2.50607193
154negative regulation of fatty acid transport (GO:2000192)2.49823715
155hyaluronan catabolic process (GO:0030214)2.48763320
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48689188
157mannose metabolic process (GO:0006013)2.47512201
158cellular response to thyroid hormone stimulus (GO:0097067)2.47075552
159G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46808195
160endothelial cell chemotaxis (GO:0035767)2.46219147
161actin filament bundle organization (GO:0061572)2.45770474
162actin filament bundle assembly (GO:0051017)2.45770474
163chondrocyte proliferation (GO:0035988)2.42115115
164activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41843382
165paraxial mesoderm development (GO:0048339)2.39882825
166regulation of NFAT protein import into nucleus (GO:0051532)2.38488916
167heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38099334
168protein heterotrimerization (GO:0070208)2.36616170
169decidualization (GO:0046697)2.36298392
170cellular protein complex localization (GO:0034629)2.34031720
171vascular endothelial growth factor signaling pathway (GO:0038084)2.33505414
172amino acid import (GO:0043090)2.32925156
173adhesion of symbiont to host (GO:0044406)2.32869939
174negative regulation of protein localization to plasma membrane (GO:1903077)2.31675854
175positive regulation of nuclease activity (GO:0032075)2.31575764
176negative regulation of anoikis (GO:2000811)2.29231576
177modulation by virus of host morphology or physiology (GO:0019048)2.28816786
178negative regulation of homotypic cell-cell adhesion (GO:0034111)2.27970934
179regulation of mammary gland epithelial cell proliferation (GO:0033599)2.27224421
180retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27083315
181glycosphingolipid catabolic process (GO:0046479)2.26383498
182Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.24431483
183membrane protein ectodomain proteolysis (GO:0006509)2.24358916
184branching involved in mammary gland duct morphogenesis (GO:0060444)2.23689265
185branching involved in salivary gland morphogenesis (GO:0060445)2.23635458
186venous blood vessel morphogenesis (GO:0048845)2.22944057
187glial cell migration (GO:0008347)2.22640135
188cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.21595732
189negative regulation of smooth muscle cell migration (GO:0014912)2.20682722
190virion attachment to host cell (GO:0019062)2.20578594
191adhesion of symbiont to host cell (GO:0044650)2.20578594
192collagen metabolic process (GO:0032963)2.19531048
193positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.19300876
194regulation of response to osmotic stress (GO:0047484)2.19265064
195positive regulation of osteoblast proliferation (GO:0033690)2.18413500
196blood vessel endothelial cell migration (GO:0043534)2.18209655
197retina vasculature morphogenesis in camera-type eye (GO:0061299)2.17467827
198cell migration involved in heart development (GO:0060973)2.17438666
199positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.17018264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60314459
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.99102759
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.53114161
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.48994970
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.48197960
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35231263
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.90553565
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.79931434
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.59641099
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40261065
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08709942
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02436058
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99153670
14MYC_22102868_ChIP-Seq_BL_Human1.96336200
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.93039303
16TCF7_22412390_ChIP-Seq_EML_Mouse1.92620252
17ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90031304
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87375827
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.85720692
20CLOCK_20551151_ChIP-Seq_293T_Human1.83140839
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82939700
22VDR_21846776_ChIP-Seq_THP-1_Human1.82294328
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60379819
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58703737
25* EP300_21415370_ChIP-Seq_HL-1_Mouse1.57362764
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55292816
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51657564
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50131703
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44359140
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43714560
31TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42984033
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42411440
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42150656
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.39411815
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39261034
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39161835
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37613402
38GATA1_19941826_ChIP-Seq_K562_Human1.36332475
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36203380
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35983101
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35069407
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33188583
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32871839
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32871839
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32871839
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32789455
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.31985603
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.31985603
49VDR_24763502_ChIP-Seq_THP-1_Human1.31898467
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.31173966
51* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29590246
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29566539
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29446762
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28916708
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28595863
56DROSHA_22980978_ChIP-Seq_HELA_Human1.27699014
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26947208
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.26868821
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26241352
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26176953
61ATF3_27146783_Chip-Seq_COLON_Human1.25227001
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23855885
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23799791
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23720144
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22528723
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20911475
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20911475
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.20324652
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20138199
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19593617
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18925824
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18807061
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18367247
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18263655
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18014638
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17332787
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17174206
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15750557
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15750557
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.15617909
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14651516
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14001231
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13086788
84KDM2B_26808549_Chip-Seq_K562_Human1.12533119
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12516638
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12409707
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11557080
88TP53_22127205_ChIP-Seq_IMR90_Human1.10204854
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09955438
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09457267
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09322476
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08333625
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08310516
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08197304
95* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07947866
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07417131
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07187700
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05156873
99ZNF263_19887448_ChIP-Seq_K562_Human1.05137643
100* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04085891
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03170356
102AR_21572438_ChIP-Seq_LNCaP_Human1.03166519
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.01697524
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.01464838
105LXR_22292898_ChIP-Seq_THP-1_Human1.00560294
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00547324
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00492910
108* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00392107
109* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99725635
110* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98941127
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.98611860
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98553321
113EZH2_27294783_Chip-Seq_ESCs_Mouse0.98461263
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98197426
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97273864
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.97272664
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.96153136
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95484816
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95418777
120NCOR1_26117541_ChIP-Seq_K562_Human0.95270087
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95115487
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94968839
123* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94707561
124SMC4_20622854_ChIP-Seq_HELA_Human0.94016699
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93380317
126* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92264591
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91964509
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91964509
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91959099
130AHR_22903824_ChIP-Seq_MCF-7_Human0.91119460
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89851254
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89607671
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89521317
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89453045
135RACK7_27058665_Chip-Seq_MCF-7_Human0.88764874
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87887858
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.86921987
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85805234
139* KDM2B_26808549_Chip-Seq_DND41_Human0.85297345
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85287758
141* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84327185
142CTCF_27219007_Chip-Seq_Bcells_Human0.84050072
143JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83718146
144* GATA2_19941826_ChIP-Seq_K562_Human0.82129609
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.81920392
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81175127
147RARB_27405468_Chip-Seq_BRAIN_Mouse0.80394996
148* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80249396
149CJUN_26792858_Chip-Seq_BT549_Human0.78732518
150EGR1_19032775_ChIP-ChIP_M12_Human0.77769586
151* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77125059
152* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77013121
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.76432001
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75569592
155ELK3_25401928_ChIP-Seq_HUVEC_Human0.75200383
156RNF2_27304074_Chip-Seq_ESCs_Mouse0.75081026
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.74884266
158STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74762466
159SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74640229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75276780
2MP0005360_urolithiasis4.12314527
3MP0000920_abnormal_myelination3.57349185
4MP0009840_abnormal_foam_cell3.50635836
5MP0005085_abnormal_gallbladder_physiolo3.39959203
6MP0003566_abnormal_cell_adhesion3.24578324
7MP0003690_abnormal_glial_cell3.21609502
8MP0003806_abnormal_nucleotide_metabolis3.17974561
9MP0005365_abnormal_bile_salt3.02501293
10MP0005257_abnormal_intraocular_pressure2.92156149
11MP0008438_abnormal_cutaneous_collagen2.87653432
12MP0008875_abnormal_xenobiotic_pharmacok2.77126798
13MP0002877_abnormal_melanocyte_morpholog2.53784690
14MP0003300_gastrointestinal_ulcer2.49651744
15MP0003091_abnormal_cell_migration2.49520305
16MP0003252_abnormal_bile_duct2.39590671
17MP0003950_abnormal_plasma_membrane2.37966693
18MP0003195_calcinosis2.36286351
19MP0003329_amyloid_beta_deposits2.27842964
20MP0005076_abnormal_cell_differentiation2.21522754
21MP0002254_reproductive_system_inflammat2.18441868
22MP0003191_abnormal_cellular_cholesterol2.16150242
23MP0001849_ear_inflammation2.12968788
24MP0010329_abnormal_lipoprotein_level2.03581048
25MP0005332_abnormal_amino_acid2.02462427
26MP0003303_peritoneal_inflammation2.01619881
27MP0005409_darkened_coat_color2.00544074
28MP0010352_gastrointestinal_tract_polyps1.97924156
29MP0009278_abnormal_bone_marrow1.96840868
30MP0005023_abnormal_wound_healing1.96837295
31MP0003453_abnormal_keratinocyte_physiol1.95423782
32MP0004510_myositis1.91715833
33MP0000604_amyloidosis1.90698496
34MP0002118_abnormal_lipid_homeostasis1.85469847
35MP0005058_abnormal_lysosome_morphology1.82504141
36MP0005083_abnormal_biliary_tract1.79705466
37MP0002998_abnormal_bone_remodeling1.73990626
38MP0005451_abnormal_body_composition1.72248886
39MP0002837_dystrophic_cardiac_calcinosis1.70850165
40MP0004130_abnormal_muscle_cell1.69488282
41MP0003634_abnormal_glial_cell1.63807767
42MP0004036_abnormal_muscle_relaxation1.59413286
43MP0000751_myopathy1.58816046
44MP0000747_muscle_weakness1.55630591
45MP0004885_abnormal_endolymph1.55535787
46MP0005330_cardiomyopathy1.50963990
47MP0005670_abnormal_white_adipose1.49128691
48MP0005666_abnormal_adipose_tissue1.48442251
49MP0010368_abnormal_lymphatic_system1.48130197
50MP0004233_abnormal_muscle_weight1.46891829
51MP0001915_intracranial_hemorrhage1.46158486
52MP0004185_abnormal_adipocyte_glucose1.45642971
53MP0002896_abnormal_bone_mineralization1.45370229
54MP0004272_abnormal_basement_membrane1.43457577
55MP0004084_abnormal_cardiac_muscle1.42736275
56MP0003448_altered_tumor_morphology1.40462888
57MP0002089_abnormal_postnatal_growth/wei1.37789257
58MP0008260_abnormal_autophagy1.36518716
59MP0005623_abnormal_meninges_morphology1.36104471
60MP0000858_altered_metastatic_potential1.35335011
61MP0005584_abnormal_enzyme/coenzyme_acti1.31867426
62MP0005508_abnormal_skeleton_morphology1.28740380
63MP0005167_abnormal_blood-brain_barrier1.28340775
64MP0002060_abnormal_skin_morphology1.26462041
65MP0006138_congestive_heart_failure1.23661809
66MP0002295_abnormal_pulmonary_circulatio1.23079984
67MP0005375_adipose_tissue_phenotype1.22394242
68MP0000609_abnormal_liver_physiology1.21586019
69MP0001958_emphysema1.20740522
70MP0001666_abnormal_nutrient_absorption1.19652474
71MP0004087_abnormal_muscle_fiber1.19325348
72MP0003705_abnormal_hypodermis_morpholog1.18050629
73MP0003656_abnormal_erythrocyte_physiolo1.15861654
74MP0003436_decreased_susceptibility_to1.12724665
75MP0003632_abnormal_nervous_system1.12670000
76MP0003075_altered_response_to1.11072620
77MP0001533_abnormal_skeleton_physiology1.09983864
78MP0003941_abnormal_skin_development1.09569386
79* MP0005464_abnormal_platelet_physiology1.09397005
80MP0004808_abnormal_hematopoietic_stem1.08350728
81MP0006054_spinal_hemorrhage1.06420648
82MP0003828_pulmonary_edema1.06363982
83MP0000749_muscle_degeneration1.04795568
84MP0005390_skeleton_phenotype1.03686896
85MP0003633_abnormal_nervous_system1.03668796
86MP0008004_abnormal_stomach_pH0.99957652
87MP0004947_skin_inflammation0.99633703
88MP0005319_abnormal_enzyme/_coenzyme0.99442963
89MP0005621_abnormal_cell_physiology0.99096754
90* MP0005595_abnormal_vascular_smooth0.97101801
91MP0000003_abnormal_adipose_tissue0.96936310
92MP0009780_abnormal_chondrocyte_physiolo0.96572171
93MP0003631_nervous_system_phenotype0.96453710
94MP0002972_abnormal_cardiac_muscle0.96318245
95MP0009672_abnormal_birth_weight0.95390949
96MP0003137_abnormal_impulse_conducting0.91691491
97MP0010630_abnormal_cardiac_muscle0.90565204
98MP0009053_abnormal_anal_canal0.90460028
99MP0001853_heart_inflammation0.90193988
100MP0001614_abnormal_blood_vessel0.89341740
101MP0004085_abnormal_heartbeat0.88082458
102MP0001542_abnormal_bone_strength0.87721696
103MP0002229_neurodegeneration0.87397988
104MP0003279_aneurysm0.87101112
105MP0000428_abnormal_craniofacial_morphol0.86991504
106MP0004270_analgesia0.86406534
107MP0009643_abnormal_urine_homeostasis0.85006797
108MP0001348_abnormal_lacrimal_gland0.84327773
109MP0010234_abnormal_vibrissa_follicle0.84251805
110MP0000537_abnormal_urethra_morphology0.82183339
111MP0002796_impaired_skin_barrier0.81980581
112MP0003221_abnormal_cardiomyocyte_apopto0.81463008
113MP0002971_abnormal_brown_adipose0.81368034
114MP0001544_abnormal_cardiovascular_syste0.81364045
115MP0005385_cardiovascular_system_phenoty0.81364045
116MP0010307_abnormal_tumor_latency0.80409333
117MP0004043_abnormal_pH_regulation0.80108221
118MP0004134_abnormal_chest_morphology0.79392125
119MP0001545_abnormal_hematopoietic_system0.79121203
120MP0005397_hematopoietic_system_phenotyp0.79121203
121MP0010030_abnormal_orbit_morphology0.78651384
122MP0001661_extended_life_span0.78454180
123MP0002090_abnormal_vision0.77139521
124MP0000534_abnormal_ureter_morphology0.76364095
125MP0000462_abnormal_digestive_system0.76347424
126MP0010678_abnormal_skin_adnexa0.75912025
127* MP0001730_embryonic_growth_arrest0.75771038
128MP0002925_abnormal_cardiovascular_devel0.75496990
129MP0005501_abnormal_skin_physiology0.75157907
130MP0005647_abnormal_sex_gland0.75115140
131MP0003795_abnormal_bone_structure0.74916891
132MP0005275_abnormal_skin_tensile0.74636580
133MP0001243_abnormal_dermal_layer0.73886798
134MP0003172_abnormal_lysosome_physiology0.72928857
135MP0003115_abnormal_respiratory_system0.72783924
136MP0004858_abnormal_nervous_system0.72193463
137MP0008775_abnormal_heart_ventricle0.71266404
138MP0006082_CNS_inflammation0.70743249
139MP0003942_abnormal_urinary_system0.70370656
140MP0009384_cardiac_valve_regurgitation0.70270387
141MP0002113_abnormal_skeleton_development0.69668501
142MP0001177_atelectasis0.69521915
143MP0005197_abnormal_uvea_morphology0.68941877
144MP0002269_muscular_atrophy0.68913283
145MP0004859_abnormal_synaptic_plasticity0.68754744
146MP0004019_abnormal_vitamin_homeostasis0.67450015
147MP0005165_increased_susceptibility_to0.67433390
148MP0000639_abnormal_adrenal_gland0.67367425
149MP0005408_hypopigmentation0.67263482
150MP0002128_abnormal_blood_circulation0.65978140
151MP0004142_abnormal_muscle_tone0.63981792
152* MP0005620_abnormal_muscle_contractility0.63910325
153MP0008874_decreased_physiological_sensi0.62961963
154MP0000733_abnormal_muscle_development0.61965559
155MP0001486_abnormal_startle_reflex0.61676448
156MP0003646_muscle_fatigue0.61239842
157MP0002108_abnormal_muscle_morphology0.60616917
158MP0005503_abnormal_tendon_morphology0.59279983
159MP0005388_respiratory_system_phenotype0.58961244
160MP0002133_abnormal_respiratory_system0.58961244
161* MP0000230_abnormal_systemic_arterial0.58753274
162MP0000343_altered_response_to0.58131135
163MP0002064_seizures0.56850007
164MP0000767_abnormal_smooth_muscle0.56684098

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.81014825
2Deep venous thrombosis (HP:0002625)4.59470217
3Protrusio acetabuli (HP:0003179)4.47176891
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.35103790
5Intrahepatic cholestasis (HP:0001406)4.35085364
6Xanthomatosis (HP:0000991)4.19604488
7Cerebral inclusion bodies (HP:0100314)3.80765771
8Complement deficiency (HP:0004431)3.79427537
9Hyperlipoproteinemia (HP:0010980)3.77581697
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.66971597
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.66971597
12Axonal loss (HP:0003447)3.58204429
13Vertebral compression fractures (HP:0002953)3.10554038
14Ankle contracture (HP:0006466)3.09655130
15Hyperacusis (HP:0010780)3.08015828
16Muscle fiber splitting (HP:0003555)2.99383855
17Abnormality of the corticospinal tract (HP:0002492)2.98369137
18Abnormality of liposaccharide metabolism (HP:0010968)2.95345512
19Abnormality of glycosphingolipid metabolism (HP:0004343)2.95345512
20Abnormality of glycolipid metabolism (HP:0010969)2.95345512
21Abnormality of glycine metabolism (HP:0010895)2.94073139
22Abnormality of serine family amino acid metabolism (HP:0010894)2.94073139
23Hyperammonemia (HP:0001987)2.93597520
24Supranuclear gaze palsy (HP:0000605)2.92238295
25Hyporeflexia of lower limbs (HP:0002600)2.90702036
26Onion bulb formation (HP:0003383)2.90610387
27Vascular tortuosity (HP:0004948)2.85365638
28Ketosis (HP:0001946)2.83726970
29Insidious onset (HP:0003587)2.83003583
30Termporal pattern (HP:0011008)2.83003583
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.81327350
32Arterial tortuosity (HP:0005116)2.79099196
33Epidermoid cyst (HP:0200040)2.76398708
34Systemic lupus erythematosus (HP:0002725)2.75965747
35Genu recurvatum (HP:0002816)2.62731567
36Cerebral hemorrhage (HP:0001342)2.60837690
37Cerebral aneurysm (HP:0004944)2.60609934
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.57837605
39Abnormality of complement system (HP:0005339)2.56859909
40Spinal rigidity (HP:0003306)2.53874200
41Abnormality of fatty-acid metabolism (HP:0004359)2.53270260
42Fragile skin (HP:0001030)2.53260892
43Obstructive sleep apnea (HP:0002870)2.51275607
44Bladder diverticulum (HP:0000015)2.50026480
45Peripheral hypomyelination (HP:0007182)2.49245611
46Nuclear cataract (HP:0100018)2.47969105
47Dysostosis multiplex (HP:0000943)2.47298279
48Intention tremor (HP:0002080)2.45486008
49Prolonged partial thromboplastin time (HP:0003645)2.44880201
50Broad metatarsal (HP:0001783)2.42406817
51Ulnar bowing (HP:0003031)2.42194350
52Hypoalphalipoproteinemia (HP:0003233)2.39672418
53Cervical subluxation (HP:0003308)2.39053126
54Hyperglycinuria (HP:0003108)2.38981560
55Atrophic scars (HP:0001075)2.37576595
56Peripheral demyelination (HP:0011096)2.37555545
57Wormian bones (HP:0002645)2.37153356
58Abnormal gallbladder physiology (HP:0012438)2.35860855
59Cholecystitis (HP:0001082)2.35860855
60Insomnia (HP:0100785)2.31808511
61Blue sclerae (HP:0000592)2.31734454
62Aortic dissection (HP:0002647)2.30628031
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28485887
64Mitral regurgitation (HP:0001653)2.26254383
65Amyloidosis (HP:0011034)2.26086637
66Skin nodule (HP:0200036)2.23512315
67Hypobetalipoproteinemia (HP:0003563)2.22519409
68Upper limb amyotrophy (HP:0009129)2.22176128
69Distal upper limb amyotrophy (HP:0007149)2.22176128
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22125303
71Hyperglycinemia (HP:0002154)2.21973421
72Difficulty running (HP:0009046)2.21568574
73Ketoacidosis (HP:0001993)2.21060582
74Spondylolisthesis (HP:0003302)2.20735078
75Premature rupture of membranes (HP:0001788)2.18766339
76Aortic aneurysm (HP:0004942)2.18395315
77Turricephaly (HP:0000262)2.17728756
78Dilatation of the ascending aorta (HP:0005111)2.16750669
79Hypoglycemic coma (HP:0001325)2.16167962
80Abnormality of methionine metabolism (HP:0010901)2.13616185
81Hypolipoproteinemia (HP:0010981)2.13181295
82Abnormal gallbladder morphology (HP:0012437)2.11010613
83Asymmetry of the thorax (HP:0001555)2.10950239
84Delayed CNS myelination (HP:0002188)2.08746558
85Fat malabsorption (HP:0002630)2.07528071
86Hypercholesterolemia (HP:0003124)2.07335406
87Foot dorsiflexor weakness (HP:0009027)2.06860410
88Sudden death (HP:0001699)2.05769708
89Spastic gait (HP:0002064)2.05561183
90Sensory axonal neuropathy (HP:0003390)2.04754809
91Broad face (HP:0000283)2.04712320
92Glomerulonephritis (HP:0000099)2.04445303
93Osteolytic defects of the hand bones (HP:0009699)2.01755553
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.01755553
95Stridor (HP:0010307)2.01421934
96Distal lower limb amyotrophy (HP:0008944)2.01117995
97Disproportionate tall stature (HP:0001519)2.00857114
98Hyperextensible skin (HP:0000974)2.00584307
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.00554922
100Cholelithiasis (HP:0001081)2.00332256
101Mitral valve prolapse (HP:0001634)1.99886422
102Abnormality of the Achilles tendon (HP:0005109)1.99338277
103Increased connective tissue (HP:0009025)1.98893915
104Bowel diverticulosis (HP:0005222)1.98294219
105Spastic tetraparesis (HP:0001285)1.97731948
106Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97702239
107Mucopolysacchariduria (HP:0008155)1.97501804
108Urinary glycosaminoglycan excretion (HP:0003541)1.97501804
109Hammertoe (HP:0001765)1.97355529
110Aneurysm (HP:0002617)1.97306423
111Vascular calcification (HP:0004934)1.97074627
112Myocardial infarction (HP:0001658)1.95076905
113Abnormal auditory evoked potentials (HP:0006958)1.95024514
114Arnold-Chiari malformation (HP:0002308)1.94990517
115Abnormality of polysaccharide metabolism (HP:0011012)1.94605838
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94605838
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94605838
118Abnormality of the common coagulation pathway (HP:0010990)1.94349080
119Protuberant abdomen (HP:0001538)1.93905849
120Pheochromocytoma (HP:0002666)1.93260679
121Segmental peripheral demyelination/remyelination (HP:0003481)1.93030897
122Renal duplication (HP:0000075)1.91924265
123Exercise-induced muscle cramps (HP:0003710)1.91079189
124Abnormality of skeletal muscle fiber size (HP:0012084)1.90818513
125Cardiovascular calcification (HP:0011915)1.89291146
126Syringomyelia (HP:0003396)1.89120700
127Spinal cord lesions (HP:0100561)1.89120700
128Abnormality of dentin (HP:0010299)1.88472197
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88465909
130Abnormality of the foot musculature (HP:0001436)1.87277175
131Joint hemorrhage (HP:0005261)1.86758737
132Exercise-induced myalgia (HP:0003738)1.86256193
133Thin bony cortex (HP:0002753)1.86168224
134Joint laxity (HP:0001388)1.85607453
135Apathy (HP:0000741)1.84339593
136Hyperparathyroidism (HP:0000843)1.84113290
137Slender build (HP:0001533)1.84018288
138Loss of speech (HP:0002371)1.82168809
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.81630469
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81555619
141Dicarboxylic aciduria (HP:0003215)1.81555619
142Short nail (HP:0001799)1.81507387
143Distal lower limb muscle weakness (HP:0009053)1.81164594
144Dysmetria (HP:0001310)1.80272708
145Flat acetabular roof (HP:0003180)1.79759380
146Ankle clonus (HP:0011448)1.79646388
147Paraparesis (HP:0002385)1.78970620
148Neonatal short-limb short stature (HP:0008921)1.78594196
149Myoglobinuria (HP:0002913)1.78503322
150Diminished motivation (HP:0000745)1.77918995
151Biconcave vertebral bodies (HP:0004586)1.77665413
152Lower limb amyotrophy (HP:0007210)1.77466030
153Overriding aorta (HP:0002623)1.76127508
154Steatorrhea (HP:0002570)1.74846244
155Congenital glaucoma (HP:0001087)1.74839971
156Neuronal loss in central nervous system (HP:0002529)1.74513421
157Generalized amyotrophy (HP:0003700)1.73364200
158Long palpebral fissure (HP:0000637)1.72022701
159Back pain (HP:0003418)1.70257956
160Abnormal ossification of hand bones (HP:0005921)1.69762724
161Soft skin (HP:0000977)1.69369414
162Coronal craniosynostosis (HP:0004440)1.67710110
163Achilles tendon contracture (HP:0001771)1.67615249
164Natal tooth (HP:0000695)1.67595089
165EMG: myopathic abnormalities (HP:0003458)1.66788296
166Buphthalmos (HP:0000557)1.66064038
167Ankyloglossia (HP:0010296)1.64783944
168Shallow orbits (HP:0000586)1.64583490
169Mitral stenosis (HP:0001718)1.64442253
170Increased variability in muscle fiber diameter (HP:0003557)1.64301960
171Polygenic inheritance (HP:0010982)1.64122835
172Spastic paraparesis (HP:0002313)1.63872423
173Ventricular tachycardia (HP:0004756)1.63817616
174Increased cerebral lipofuscin (HP:0011813)1.63689672
175Abnormality of the thoracic spine (HP:0100711)1.63131007
176Rapidly progressive (HP:0003678)1.62268995
177Hand muscle atrophy (HP:0009130)1.62229845
178Advanced eruption of teeth (HP:0006288)1.61840657
179Abnormality of oral frenula (HP:0000190)1.60647346
180Bone pain (HP:0002653)1.60439743
181Elfin facies (HP:0004428)1.58793461
182Cupped ribs (HP:0000887)1.58689416
183Abnormality of the acetabulum (HP:0003170)1.57997317
184Hypoventilation (HP:0002791)1.56653972
185Abnormality of carpal bone ossification (HP:0006257)1.56421880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.22937333
2EPHB13.60222586
3IRAK33.43587958
4OXSR12.61705551
5TRIB32.53232021
6SMG12.30151182
7BCKDK2.30037419
8PKN12.24216360
9MET2.23921576
10FGFR22.16651683
11TAOK22.14607394
12MAPKAPK52.05547243
13WNK41.96603191
14ICK1.92297584
15LMTK21.86548638
16NME21.84509661
17NTRK11.75504913
18CDK121.74194078
19PAK41.67907437
20TESK11.65496876
21TTN1.65293775
22DMPK1.64100439
23PHKG21.60966948
24PHKG11.60966948
25PKN21.60466036
26WNK11.58028557
27ARAF1.57711112
28KSR21.51198691
29EEF2K1.45937423
30PAK61.43590689
31PRKD31.43227754
32SIK11.41616071
33MAP2K31.39302991
34PRKD11.36227473
35SGK2231.35288681
36SGK4941.35288681
37TIE11.33317581
38CDC42BPA1.33129474
39PTK61.25407737
40LIMK11.23805882
41ROCK21.23527146
42MOS1.22512378
43CSNK1A1L1.21592920
44CAMK1G1.20732379
45TYRO31.18389705
46CSNK1G31.18016632
47EPHA21.16813055
48PAK31.14711765
49MAP3K91.12945797
50CSNK1G11.08833406
51TGFBR21.08657889
52MAP3K101.07937036
53MAP3K31.03882840
54NEK91.03742139
55UHMK11.03415387
56BCR1.03312939
57CAMK2D1.03235796
58TRPM71.00949780
59RIPK11.00629352
60RPS6KA20.98505622
61FGR0.98034845
62MAP3K130.97914252
63PRKD20.96684106
64MAP3K70.95330836
65BMX0.94123016
66CAMK1D0.93726979
67CSNK1G20.91810575
68EPHB20.90565379
69PDPK10.90457087
70CLK10.89024901
71PDGFRA0.89019443
72PRPF4B0.87671415
73MAP3K60.87395902
74ERBB40.87023372
75PRKCH0.86399701
76TAOK10.84372116
77DDR20.84142676
78MAPK150.83588511
79MAP3K110.82689114
80LATS10.81798316
81FGFR40.81415050
82PINK10.81236843
83CAMK2B0.78929599
84PTK2B0.78737036
85CAMK2G0.78088067
86GSK3A0.77986545
87RET0.77471522
88MAP3K140.77435998
89MAP3K80.76554440
90STK380.75165760
91ERN10.72303205
92PRKG20.71714023
93MAP3K20.70440934
94ZAP700.69613621
95EPHA40.69502091
96PAK20.68684853
97SCYL20.67306430
98MAPK120.65829454
99BRAF0.65614278
100PRKAA20.62987206
101ROCK10.61639673
102RPS6KC10.61113578
103RPS6KL10.61113578
104PRKCQ0.60839718
105MAP2K20.60689388
106ILK0.60560552
107HIPK20.58700512
108TESK20.57622867
109MARK20.57609873
110PBK0.57520953
111PDK20.56762844
112PDGFRB0.52512854
113SGK30.52359183
114CAMK2A0.51515038
115PTK20.51256791
116PDK10.50858586
117CSF1R0.50719593
118TBK10.50120634
119PRKACB0.49766757
120IRAK20.49527600
121CDK60.48101557
122CDK50.47971662
123MATK0.47821654
124DAPK30.47507822
125LATS20.46040570
126MAPK70.45624302
127OBSCN0.45071658
128STK110.44955311
129CDK90.44349689
130CDK140.43950336
131PRKCZ0.43743014
132MTOR0.43521158
133FYN0.43114198
134DAPK20.42157935
135MAP3K10.41131839
136MELK0.38266126
137CDK150.38262180
138ALK0.38088089
139ABL20.37665379
140MYLK0.36536024
141PIM20.34014107
142CDK11A0.33674492
143RPS6KA60.31024180
144CDK40.30204326
145MAPK100.28637501
146FGFR30.28265465

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.06093469
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.18820654
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.00462347
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.88521000
5Fatty acid elongation_Homo sapiens_hsa000622.84410788
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55177323
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53920634
8Other glycan degradation_Homo sapiens_hsa005112.47439282
9Steroid biosynthesis_Homo sapiens_hsa001002.44885813
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44227103
11Butanoate metabolism_Homo sapiens_hsa006502.39067152
12Fatty acid degradation_Homo sapiens_hsa000712.36737322
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32472564
14Propanoate metabolism_Homo sapiens_hsa006402.28794653
15Fatty acid metabolism_Homo sapiens_hsa012122.23723506
16Arginine biosynthesis_Homo sapiens_hsa002202.19701814
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09173599
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04364302
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91458382
20PPAR signaling pathway_Homo sapiens_hsa033201.87822832
21Chronic myeloid leukemia_Homo sapiens_hsa052201.87251288
22Complement and coagulation cascades_Homo sapiens_hsa046101.86400924
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82803421
24Bladder cancer_Homo sapiens_hsa052191.82781951
25Tryptophan metabolism_Homo sapiens_hsa003801.79553340
26Histidine metabolism_Homo sapiens_hsa003401.74772961
27Peroxisome_Homo sapiens_hsa041461.54005564
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53374049
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51821570
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.48853124
31Sulfur metabolism_Homo sapiens_hsa009201.47541914
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46136822
33Vitamin B6 metabolism_Homo sapiens_hsa007501.45934490
34Proteoglycans in cancer_Homo sapiens_hsa052051.45033252
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44854813
36Bile secretion_Homo sapiens_hsa049761.42897787
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42422860
38Notch signaling pathway_Homo sapiens_hsa043301.41686059
39Pancreatic cancer_Homo sapiens_hsa052121.39583382
40Acute myeloid leukemia_Homo sapiens_hsa052211.37554780
41beta-Alanine metabolism_Homo sapiens_hsa004101.36440081
42Staphylococcus aureus infection_Homo sapiens_hsa051501.36438544
43Endometrial cancer_Homo sapiens_hsa052131.35481358
44VEGF signaling pathway_Homo sapiens_hsa043701.35104737
45Adherens junction_Homo sapiens_hsa045201.33156203
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.30799524
47Arginine and proline metabolism_Homo sapiens_hsa003301.23917401
48Pyruvate metabolism_Homo sapiens_hsa006201.22954638
49Non-small cell lung cancer_Homo sapiens_hsa052231.18271424
50Shigellosis_Homo sapiens_hsa051311.17650994
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.16826456
52Osteoclast differentiation_Homo sapiens_hsa043801.16009940
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14798972
54Glioma_Homo sapiens_hsa052141.13985340
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12922498
56Chemical carcinogenesis_Homo sapiens_hsa052041.12795142
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12413862
58* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12246207
59Small cell lung cancer_Homo sapiens_hsa052221.12197612
60Salmonella infection_Homo sapiens_hsa051321.11916793
61MicroRNAs in cancer_Homo sapiens_hsa052061.11753390
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09708603
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.08072319
64Vibrio cholerae infection_Homo sapiens_hsa051101.06294842
65TNF signaling pathway_Homo sapiens_hsa046681.06245213
66Malaria_Homo sapiens_hsa051441.05645786
67ErbB signaling pathway_Homo sapiens_hsa040121.05351375
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04779911
69Thyroid cancer_Homo sapiens_hsa052161.04472151
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03983929
71Estrogen signaling pathway_Homo sapiens_hsa049151.02565443
72Caffeine metabolism_Homo sapiens_hsa002320.97845795
73ABC transporters_Homo sapiens_hsa020100.97061980
74B cell receptor signaling pathway_Homo sapiens_hsa046620.96683646
75Carbon metabolism_Homo sapiens_hsa012000.96401414
76Prostate cancer_Homo sapiens_hsa052150.96263393
77Ether lipid metabolism_Homo sapiens_hsa005650.95877213
78Toxoplasmosis_Homo sapiens_hsa051450.94268442
79* Sphingolipid signaling pathway_Homo sapiens_hsa040710.92436087
80mTOR signaling pathway_Homo sapiens_hsa041500.91985426
81Prolactin signaling pathway_Homo sapiens_hsa049170.90500478
82GnRH signaling pathway_Homo sapiens_hsa049120.89496373
83Tyrosine metabolism_Homo sapiens_hsa003500.89122948
84Rap1 signaling pathway_Homo sapiens_hsa040150.88314609
85Insulin signaling pathway_Homo sapiens_hsa049100.88181654
86Fatty acid biosynthesis_Homo sapiens_hsa000610.88022147
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87930629
88Gap junction_Homo sapiens_hsa045400.87808252
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85914221
90Hepatitis C_Homo sapiens_hsa051600.85841951
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85789479
92Pertussis_Homo sapiens_hsa051330.84955506
93Phenylalanine metabolism_Homo sapiens_hsa003600.83580564
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83373736
95Retinol metabolism_Homo sapiens_hsa008300.83330124
96Hepatitis B_Homo sapiens_hsa051610.82248823
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81068855
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80626594
99Colorectal cancer_Homo sapiens_hsa052100.80300006
100Galactose metabolism_Homo sapiens_hsa000520.79695170
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78441067
102Pentose phosphate pathway_Homo sapiens_hsa000300.78218336
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77977797
104Biosynthesis of amino acids_Homo sapiens_hsa012300.76964943
105Fat digestion and absorption_Homo sapiens_hsa049750.76615398
106Glycerolipid metabolism_Homo sapiens_hsa005610.76589870
107Prion diseases_Homo sapiens_hsa050200.76348896
108Starch and sucrose metabolism_Homo sapiens_hsa005000.75095307
109Lysine degradation_Homo sapiens_hsa003100.74950954
110Melanoma_Homo sapiens_hsa052180.74443592
111HIF-1 signaling pathway_Homo sapiens_hsa040660.71705437
112Platelet activation_Homo sapiens_hsa046110.71402234
113* Pathways in cancer_Homo sapiens_hsa052000.70846626
114Leishmaniasis_Homo sapiens_hsa051400.69255543
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68904052
116Choline metabolism in cancer_Homo sapiens_hsa052310.68065059
117Hippo signaling pathway_Homo sapiens_hsa043900.67821203
118Long-term potentiation_Homo sapiens_hsa047200.66790175
119Phagosome_Homo sapiens_hsa041450.66304893
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66286075
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65552759
122Tuberculosis_Homo sapiens_hsa051520.64639419
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64062498
124Apoptosis_Homo sapiens_hsa042100.63700148
125Lysosome_Homo sapiens_hsa041420.63492380
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63214494
127Chemokine signaling pathway_Homo sapiens_hsa040620.62761496
128Influenza A_Homo sapiens_hsa051640.61727521
129Melanogenesis_Homo sapiens_hsa049160.61093625
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60806443
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.57998273
132* MAPK signaling pathway_Homo sapiens_hsa040100.57995848
133ECM-receptor interaction_Homo sapiens_hsa045120.55707757
134Ovarian steroidogenesis_Homo sapiens_hsa049130.54973909
135Vitamin digestion and absorption_Homo sapiens_hsa049770.54816908
136Linoleic acid metabolism_Homo sapiens_hsa005910.54783563
137HTLV-I infection_Homo sapiens_hsa051660.54750468
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53614721
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53484436
140Folate biosynthesis_Homo sapiens_hsa007900.53455275
141Glutathione metabolism_Homo sapiens_hsa004800.53214142
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52085076
143Dilated cardiomyopathy_Homo sapiens_hsa054140.51934767
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.51375964
145Renal cell carcinoma_Homo sapiens_hsa052110.51091458
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50030913
147Selenocompound metabolism_Homo sapiens_hsa004500.42844546
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.41694851
149Axon guidance_Homo sapiens_hsa043600.40512049
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38305032
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38033092
152Dorso-ventral axis formation_Homo sapiens_hsa043200.37919259
153Insulin resistance_Homo sapiens_hsa049310.37208743
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.34633223
155Focal adhesion_Homo sapiens_hsa045100.33762401
156Tight junction_Homo sapiens_hsa045300.32844446
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31313621
158Amoebiasis_Homo sapiens_hsa051460.30820789
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30188141
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.29951665
161Endocytosis_Homo sapiens_hsa041440.27899659
162* Phospholipase D signaling pathway_Homo sapiens_hsa040720.26965659
163Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25671357
164Metabolic pathways_Homo sapiens_hsa011000.25399684
165AMPK signaling pathway_Homo sapiens_hsa041520.24585233
166Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24035697
167Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23326138
168Cardiac muscle contraction_Homo sapiens_hsa042600.22993671
169Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20074052
170Sphingolipid metabolism_Homo sapiens_hsa006000.14026852
171Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13777842
172Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13552313
173Cocaine addiction_Homo sapiens_hsa050300.11960165
174Protein digestion and absorption_Homo sapiens_hsa049740.11830737
175Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10154123
176GABAergic synapse_Homo sapiens_hsa047270.09786541
177Ras signaling pathway_Homo sapiens_hsa040140.09317290
178Sulfur relay system_Homo sapiens_hsa041220.09055157

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