GNA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59363183
2modulation by symbiont of host defense response (GO:0052031)4.95924223
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95924223
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95924223
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.95924223
6modulation by symbiont of host immune response (GO:0052553)4.95924223
7positive regulation by symbiont of host defense response (GO:0052509)4.95924223
8positive regulation of gamma-delta T cell activation (GO:0046645)4.54695648
9regulation of interleukin-12 biosynthetic process (GO:0045075)4.13191988
10regulation of interferon-beta biosynthetic process (GO:0045357)4.02078459
11positive regulation of interferon-alpha production (GO:0032727)3.96627186
12cellular extravasation (GO:0045123)3.94917173
13regulation of interferon-alpha production (GO:0032647)3.89187129
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88382381
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88382381
16negative regulation of erythrocyte differentiation (GO:0045647)3.78162695
17antigen processing and presentation of endogenous antigen (GO:0019883)3.75779545
18tolerance induction (GO:0002507)3.73624953
19macrophage activation involved in immune response (GO:0002281)3.70248067
20response to muramyl dipeptide (GO:0032495)3.62411584
21detection of molecule of bacterial origin (GO:0032490)3.60764020
22detection of other organism (GO:0098543)3.57764289
23regulation of gamma-delta T cell differentiation (GO:0045586)3.52121917
24neutrophil activation involved in immune response (GO:0002283)3.51796137
25regulation of gamma-delta T cell activation (GO:0046643)3.48822428
26negative regulation of cell killing (GO:0031342)3.40000903
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40000903
28JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.34653378
29immunoglobulin mediated immune response (GO:0016064)3.32982838
30regulation of B cell receptor signaling pathway (GO:0050855)3.31753479
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.27714543
32germinal center formation (GO:0002467)3.23939221
33positive thymic T cell selection (GO:0045059)3.22296304
34production of molecular mediator involved in inflammatory response (GO:0002532)3.20703506
35positive regulation of interferon-beta production (GO:0032728)3.20631817
36detection of bacterium (GO:0016045)3.17854298
37response to peptidoglycan (GO:0032494)3.17574802
38detection of external biotic stimulus (GO:0098581)3.17148833
39response to type I interferon (GO:0034340)3.14949998
40myeloid dendritic cell differentiation (GO:0043011)3.10992458
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08714011
42response to host immune response (GO:0052572)3.08714011
43leukocyte aggregation (GO:0070486)3.08495533
44type I interferon signaling pathway (GO:0060337)3.07938475
45cellular response to type I interferon (GO:0071357)3.07938475
46interferon-gamma-mediated signaling pathway (GO:0060333)3.05646845
47positive regulation of natural killer cell differentiation (GO:0032825)3.05370839
48NIK/NF-kappaB signaling (GO:0038061)3.04199873
49granulocyte activation (GO:0036230)3.03083483
50T cell migration (GO:0072678)2.99465444
51lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99439774
52natural killer cell mediated immunity (GO:0002228)2.98492271
53natural killer cell mediated cytotoxicity (GO:0042267)2.98492271
54positive regulation of interleukin-12 production (GO:0032735)2.97901257
55neutrophil activation (GO:0042119)2.97334215
56myeloid dendritic cell activation (GO:0001773)2.96364924
57response to host (GO:0075136)2.95519076
58response to host defenses (GO:0052200)2.95519076
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95519076
60negative thymic T cell selection (GO:0045060)2.93046997
61detection of biotic stimulus (GO:0009595)2.91907920
62negative T cell selection (GO:0043383)2.91655536
63embryonic process involved in female pregnancy (GO:0060136)2.89927772
64negative regulation of B cell proliferation (GO:0030889)2.89758722
65interferon-gamma production (GO:0032609)2.88738534
66microglial cell activation (GO:0001774)2.87417194
67positive regulation of B cell differentiation (GO:0045579)2.87353105
68regulation of mast cell degranulation (GO:0043304)2.87109494
69myeloid cell activation involved in immune response (GO:0002275)2.85518304
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85106188
71positive regulation of mast cell activation (GO:0033005)2.83697307
72positive regulation of heat generation (GO:0031652)2.79084711
73cytokine secretion (GO:0050663)2.78089590
74regulation of T-helper 2 cell differentiation (GO:0045628)2.77589083
75regulation of leukocyte degranulation (GO:0043300)2.77139958
76positive regulation of cellular amide metabolic process (GO:0034250)2.76347009
77negative regulation of interleukin-12 production (GO:0032695)2.75258456
78natural killer cell differentiation (GO:0001779)2.73087742
79regulation of interleukin-12 production (GO:0032655)2.72803259
80negative regulation of T-helper cell differentiation (GO:0045623)2.71831980
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71831980
82positive regulation of interleukin-2 production (GO:0032743)2.70104481
83I-kappaB phosphorylation (GO:0007252)2.69522717
84leukocyte cell-cell adhesion (GO:0007159)2.68684999
85thymic T cell selection (GO:0045061)2.68666861
86positive regulation of chemokine biosynthetic process (GO:0045080)2.68666377
87positive regulation of T cell cytokine production (GO:0002726)2.68585710
88negative regulation of T cell mediated immunity (GO:0002710)2.66824915
89hepatocyte apoptotic process (GO:0097284)2.66538583
90histone H3-K36 demethylation (GO:0070544)2.66439187
91macrophage activation (GO:0042116)2.66156458
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65312361
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64738957
94regulation of alpha-beta T cell proliferation (GO:0046640)2.64233837
95regulation of mast cell activation involved in immune response (GO:0033006)2.64230037
96response to laminar fluid shear stress (GO:0034616)2.63387542
97regulation of B cell differentiation (GO:0045577)2.62290405
98B cell receptor signaling pathway (GO:0050853)2.61876499
99regulation of fever generation (GO:0031620)2.61291573
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61101225
101regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60445387
102regulation of T-helper 1 cell differentiation (GO:0045625)2.60397119
103positive regulation of antigen processing and presentation (GO:0002579)2.58518595
104defense response to protozoan (GO:0042832)2.58367289
105T cell selection (GO:0045058)2.58250738
106regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58032910
107B cell mediated immunity (GO:0019724)2.57845167
108positive regulation of cytokine biosynthetic process (GO:0042108)2.56931001
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.55843364
110regulation of chronic inflammatory response (GO:0002676)2.55592523
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55473541
112regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55202985
113regulation of mast cell activation (GO:0033003)2.54397831
114T-helper 1 type immune response (GO:0042088)2.54356492
115B cell homeostasis (GO:0001782)2.53320019
116respiratory burst (GO:0045730)2.53234771
117response to interleukin-15 (GO:0070672)2.52857223
118cellular response to interferon-gamma (GO:0071346)2.51434473
119regulation of tolerance induction (GO:0002643)2.51262627
120cellular response to thyroid hormone stimulus (GO:0097067)2.51115924
121positive regulation of leukocyte degranulation (GO:0043302)2.50616448
122positive regulation of isotype switching (GO:0045830)2.50491609
123negative regulation of lymphocyte mediated immunity (GO:0002707)2.50044819
124positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.49947790
125dendritic cell differentiation (GO:0097028)2.48954121
126regulation of T cell tolerance induction (GO:0002664)2.48913887
127natural killer cell activation (GO:0030101)2.48649941
128response to protozoan (GO:0001562)2.48390560
129myeloid leukocyte activation (GO:0002274)2.48236628
130negative regulation of interleukin-17 production (GO:0032700)2.48130813
131antigen processing and presentation via MHC class Ib (GO:0002475)2.47594494
132cellular response to zinc ion (GO:0071294)2.47332889
133monocyte chemotaxis (GO:0002548)2.47266370
134Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46900188
135regulation of interferon-beta production (GO:0032648)2.46873604
136positive T cell selection (GO:0043368)2.46578236
137G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.43613531
138dendritic cell chemotaxis (GO:0002407)2.42980598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.39090636
2* IRF8_22096565_ChIP-ChIP_GC-B_Human4.98029111
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.43045731
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.24089795
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.14247902
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.90232487
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.81680121
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.40236723
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33443394
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26929058
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23032604
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15726265
13* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12163820
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85672072
15E2F7_22180533_ChIP-Seq_HELA_Human2.84729283
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.67614476
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67082122
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64051427
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54715958
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49712947
21RUNX_20019798_ChIP-Seq_JUKART_Human2.44009777
22MYB_26560356_Chip-Seq_TH2_Human2.31966793
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29109766
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.28315468
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18890991
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09655714
27* MYC_22102868_ChIP-Seq_BL_Human2.06648070
28* MAF_26560356_Chip-Seq_TH1_Human2.06206237
29MYB_26560356_Chip-Seq_TH1_Human1.95065275
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90902545
31SCL_19346495_ChIP-Seq_HPC-7_Human1.86402343
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80155704
33GATA1_22025678_ChIP-Seq_K562_Human1.79927902
34VDR_21846776_ChIP-Seq_THP-1_Human1.79425092
35TCF7_22412390_ChIP-Seq_EML_Mouse1.75760119
36VDR_24763502_ChIP-Seq_THP-1_Human1.73997683
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.71754715
38SPI1_23547873_ChIP-Seq_NB4_Human1.71049783
39* PU_27001747_Chip-Seq_BMDM_Mouse1.63798351
40SPI1_23127762_ChIP-Seq_K562_Human1.60926682
41UTX_26944678_Chip-Seq_JUKART_Human1.59772680
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51498703
43GATA3_27048872_Chip-Seq_THYMUS_Human1.48535623
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.43874767
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43847930
46* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41620814
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.41612819
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40866559
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38919523
50VDR_24787735_ChIP-Seq_THP-1_Human1.38112819
51* FOXO3_23340844_ChIP-Seq_DLD1_Human1.37498676
52KDM2B_26808549_Chip-Seq_DND41_Human1.33101173
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31908075
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27872019
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27344800
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22981544
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.18877140
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15623677
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15158731
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14312407
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14312407
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14312407
63MAF_26560356_Chip-Seq_TH2_Human1.13782667
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11474933
65* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11128180
66* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10776920
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10464965
68* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09899482
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09256088
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.07998168
71CLOCK_20551151_ChIP-Seq_293T_Human1.07752925
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07465461
73* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07421276
74GATA3_26560356_Chip-Seq_TH2_Human1.06493609
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.06281291
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05246826
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05106060
78* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05090408
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01241722
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01156863
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01156863
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98713254
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95175038
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93739479
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93687240
86* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92800073
87ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92446247
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91592645
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90816760
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.89533249
91* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86428232
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85807266
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.85487735
94NCOR1_26117541_ChIP-Seq_K562_Human0.84606867
95GATA1_19941826_ChIP-Seq_K562_Human0.84194351
96GATA2_19941826_ChIP-Seq_K562_Human0.84184919
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84115375
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.83856269
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83643539
100* TFEB_21752829_ChIP-Seq_HELA_Human0.83547529
101* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83483497
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82658022
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79265674
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79083551
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78445724
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78232506
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76765414
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76471281
109UBF1/2_26484160_Chip-Seq_HMECs_Human0.75890522
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74554667
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74211273
112GATA6_25053715_ChIP-Seq_YYC3_Human0.73368519
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72317750
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71974275
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71897515
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.71892143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.63352080
2MP0001835_abnormal_antigen_presentation3.62138202
3MP0003436_decreased_susceptibility_to3.07979805
4MP0003300_gastrointestinal_ulcer2.98136890
5MP0001790_abnormal_immune_system2.85015014
6MP0005387_immune_system_phenotype2.85015014
7MP0000685_abnormal_immune_system2.82161643
8MP0005000_abnormal_immune_tolerance2.77602277
9MP0009785_altered_susceptibility_to2.71482225
10MP0001800_abnormal_humoral_immune2.67424348
11MP0005671_abnormal_response_to2.66832311
12MP0002452_abnormal_antigen_presenting2.53518415
13MP0006082_CNS_inflammation2.45306132
14MP0002419_abnormal_innate_immunity2.42329865
15MP0002148_abnormal_hypersensitivity_rea2.41369121
16MP0002723_abnormal_immune_serum2.38949371
17MP0005025_abnormal_response_to2.32307328
18MP0004510_myositis2.30890052
19MP0001819_abnormal_immune_cell2.20098292
20MP0002420_abnormal_adaptive_immunity2.18864761
21MP0003724_increased_susceptibility_to2.18747962
22MP0008057_abnormal_DNA_replication2.18164722
23MP0004947_skin_inflammation2.06699512
24MP0002166_altered_tumor_susceptibility1.99462935
25MP0002405_respiratory_system_inflammati1.97125884
26MP0009278_abnormal_bone_marrow1.95570879
27MP0010352_gastrointestinal_tract_polyps1.94291504
28MP0010155_abnormal_intestine_physiology1.93979259
29MP0005076_abnormal_cell_differentiation1.92109635
30MP0005058_abnormal_lysosome_morphology1.92051376
31MP0002006_tumorigenesis1.87017665
32MP0003763_abnormal_thymus_physiology1.86696904
33MP0001853_heart_inflammation1.84810261
34MP0005451_abnormal_body_composition1.84632845
35MP0002398_abnormal_bone_marrow1.82468346
36MP0003448_altered_tumor_morphology1.78982153
37MP0000716_abnormal_immune_system1.73923451
38MP0000569_abnormal_digit_pigmentation1.72604042
39MP0001533_abnormal_skeleton_physiology1.72246846
40MP0001845_abnormal_inflammatory_respons1.67126385
41* MP0005464_abnormal_platelet_physiology1.59231595
42MP0009333_abnormal_splenocyte_physiolog1.53839280
43MP0010307_abnormal_tumor_latency1.50707213
44MP0001545_abnormal_hematopoietic_system1.50328466
45MP0005397_hematopoietic_system_phenotyp1.50328466
46MP0000689_abnormal_spleen_morphology1.48411288
47MP0008004_abnormal_stomach_pH1.46809110
48MP0002722_abnormal_immune_system1.46382348
49MP0000858_altered_metastatic_potential1.45737198
50MP0001873_stomach_inflammation1.45229150
51MP0008260_abnormal_autophagy1.45204011
52MP0004808_abnormal_hematopoietic_stem1.44889535
53MP0003656_abnormal_erythrocyte_physiolo1.42100709
54MP0003566_abnormal_cell_adhesion1.41792045
55MP0002429_abnormal_blood_cell1.41585291
56MP0003172_abnormal_lysosome_physiology1.39874599
57MP0002998_abnormal_bone_remodeling1.34573709
58MP0005310_abnormal_salivary_gland1.34513080
59MP0002254_reproductive_system_inflammat1.31083629
60MP0005167_abnormal_blood-brain_barrier1.27182324
61MP0000703_abnormal_thymus_morphology1.26731623
62MP0000465_gastrointestinal_hemorrhage1.25237377
63MP0002396_abnormal_hematopoietic_system1.23876494
64MP0008469_abnormal_protein_level1.20455499
65MP0003453_abnormal_keratinocyte_physiol1.19861777
66MP0002933_joint_inflammation1.19736410
67MP0003091_abnormal_cell_migration1.16524201
68MP0004381_abnormal_hair_follicle1.16410896
69MP0003705_abnormal_hypodermis_morpholog1.15204182
70MP0003866_abnormal_defecation1.14159082
71MP0000343_altered_response_to1.12341776
72MP0001851_eye_inflammation1.12293499
73MP0003191_abnormal_cellular_cholesterol1.11827402
74MP0009764_decreased_sensitivity_to1.10322188
75MP0004264_abnormal_extraembryonic_tissu1.08052722
76MP0000490_abnormal_crypts_of1.07042676
77MP0003075_altered_response_to1.04726647
78MP0009840_abnormal_foam_cell1.04714190
79MP0004883_abnormal_blood_vessel1.03140075
80MP0005023_abnormal_wound_healing1.02478440
81MP0003828_pulmonary_edema1.01637386
82MP0003221_abnormal_cardiomyocyte_apopto0.99605150
83MP0005166_decreased_susceptibility_to0.96747920
84MP0000604_amyloidosis0.95832128
85MP0000015_abnormal_ear_pigmentation0.92320882
86MP0003045_fibrosis0.91801280
87MP0002277_abnormal_respiratory_mucosa0.90317325
88MP0003690_abnormal_glial_cell0.87435428
89MP0002138_abnormal_hepatobiliary_system0.86992620
90MP0002877_abnormal_melanocyte_morpholog0.85438103
91MP0000249_abnormal_blood_vessel0.84896429
92MP0005390_skeleton_phenotype0.83757567
93MP0000733_abnormal_muscle_development0.83227608
94MP0005075_abnormal_melanosome_morpholog0.80983466
95MP0003183_abnormal_peptide_metabolism0.80557304
96MP0005164_abnormal_response_to0.80192721
97MP0005409_darkened_coat_color0.78803739
98MP0005621_abnormal_cell_physiology0.78046077
99MP0001881_abnormal_mammary_gland0.77144118
100MP0005174_abnormal_tail_pigmentation0.73724982
101MP0009763_increased_sensitivity_to0.72057449
102MP0003795_abnormal_bone_structure0.71819147
103MP0001915_intracranial_hemorrhage0.71309106
104MP0006054_spinal_hemorrhage0.69620214
105MP0000371_diluted_coat_color0.68598710
106MP0002019_abnormal_tumor_incidence0.67520644
107MP0000767_abnormal_smooth_muscle0.67158992
108MP0005666_abnormal_adipose_tissue0.67121285
109MP0002136_abnormal_kidney_physiology0.66738459
110MP0000627_abnormal_mammary_gland0.63729872
111MP0010234_abnormal_vibrissa_follicle0.62513005
112MP0002009_preneoplasia0.61558145
113MP0001216_abnormal_epidermal_layer0.61521856
114MP0004185_abnormal_adipocyte_glucose0.60841184
115MP0000609_abnormal_liver_physiology0.58522863

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.32027079
2Recurrent abscess formation (HP:0002722)4.77444559
3Recurrent bacterial skin infections (HP:0005406)4.44282812
4Myositis (HP:0100614)4.16386099
5Orchitis (HP:0100796)4.05344385
6Optic neuritis (HP:0100653)4.02992938
7Retrobulbar optic neuritis (HP:0100654)4.02992938
8Recurrent fungal infections (HP:0002841)3.82422536
9Autoimmune thrombocytopenia (HP:0001973)3.71013899
10Recurrent viral infections (HP:0004429)3.69018731
11Mediastinal lymphadenopathy (HP:0100721)3.66807118
12Stomatitis (HP:0010280)3.60158820
13Elevated erythrocyte sedimentation rate (HP:0003565)3.56333742
14Abnormality of macrophages (HP:0004311)3.55829306
15Recurrent gram-negative bacterial infections (HP:0005420)3.47351129
16Increased cerebral lipofuscin (HP:0011813)3.41071219
17Vasculitis (HP:0002633)3.13006643
18Hematochezia (HP:0002573)3.09001336
19T lymphocytopenia (HP:0005403)3.03374416
20Abnormality of T cell number (HP:0011839)3.03170120
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.02898786
22Cellulitis (HP:0100658)3.00465243
23Chronic otitis media (HP:0000389)2.99646033
24Recurrent skin infections (HP:0001581)2.95244278
25Interstitial pulmonary disease (HP:0006530)2.90924535
26Arterial thrombosis (HP:0004420)2.89751953
27Prolonged bleeding time (HP:0003010)2.85305626
28Pulmonary infiltrates (HP:0002113)2.83805658
29Gingivitis (HP:0000230)2.79525749
30Myocardial infarction (HP:0001658)2.76012519
31Persistence of primary teeth (HP:0006335)2.71988421
32Chronic obstructive pulmonary disease (HP:0006510)2.71374092
33Obstructive lung disease (HP:0006536)2.71374092
34Recurrent bronchitis (HP:0002837)2.69180525
35Recurrent cutaneous fungal infections (HP:0011370)2.63975640
36Chronic mucocutaneous candidiasis (HP:0002728)2.63975640
37Vacuolated lymphocytes (HP:0001922)2.62682382
38Abnormality of the fingertips (HP:0001211)2.61913851
39Abnormal platelet volume (HP:0011876)2.57960587
40Epistaxis (HP:0000421)2.56395433
41Osteomyelitis (HP:0002754)2.52296856
42Pustule (HP:0200039)2.52226792
43Meningitis (HP:0001287)2.50107922
44Nasal polyposis (HP:0100582)2.49458660
45Periodontitis (HP:0000704)2.48613797
46Chest pain (HP:0100749)2.48141406
47Keratoconjunctivitis sicca (HP:0001097)2.44802388
48Disinhibition (HP:0000734)2.44754400
49Papillary thyroid carcinoma (HP:0002895)2.44306120
50Abnormality of T cells (HP:0002843)2.43696731
51Leukocytosis (HP:0001974)2.43343277
52Spontaneous hematomas (HP:0007420)2.42287337
53Thyroiditis (HP:0100646)2.39020311
54Basal ganglia calcification (HP:0002135)2.37696124
55Hemoptysis (HP:0002105)2.37475706
56Inflammation of the large intestine (HP:0002037)2.37239182
57Encephalitis (HP:0002383)2.37024613
58Colitis (HP:0002583)2.35548981
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32909247
60IgA deficiency (HP:0002720)2.32138379
61Osteolytic defects of the hand bones (HP:0009699)2.31425594
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.31425594
63Abnormality of the nasal mucosa (HP:0000433)2.31252482
64Tetraparesis (HP:0002273)2.30648827
65Thick nail (HP:0001805)2.30538509
66Increased mean platelet volume (HP:0011877)2.29967884
67IgM deficiency (HP:0002850)2.29116828
68Increased density of long bones (HP:0006392)2.26515391
69Gastrointestinal inflammation (HP:0004386)2.25841832
70Spinal cord lesions (HP:0100561)2.25544466
71Syringomyelia (HP:0003396)2.25544466
72Keratoconjunctivitis (HP:0001096)2.21513692
73Subacute progressive viral hepatitis (HP:0006572)2.21342046
74Increased IgE level (HP:0003212)2.17719160
75Eosinophilia (HP:0001880)2.17286199
76Prostate neoplasm (HP:0100787)2.16749427
77Loss of speech (HP:0002371)2.16245572
78Fatigue (HP:0012378)2.14952598
79Urticaria (HP:0001025)2.14767827
80Combined immunodeficiency (HP:0005387)2.14374877
81Severe combined immunodeficiency (HP:0004430)2.12387015
82Chronic diarrhea (HP:0002028)2.08872046
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08155759
84Amaurosis fugax (HP:0100576)2.06431044
85Lymphopenia (HP:0001888)2.06225050
86Premature loss of primary teeth (HP:0006323)2.04880990
87Systemic lupus erythematosus (HP:0002725)2.04422090
88Slow saccadic eye movements (HP:0000514)2.03235790
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.02514950
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.01392135
91Abnormality of T cell physiology (HP:0011840)2.00973513
92Gastrointestinal stroma tumor (HP:0100723)2.00403325
93Abnormality of eosinophils (HP:0001879)1.98627668
94Amyloidosis (HP:0011034)1.98577532
95Gastrointestinal infarctions (HP:0005244)1.98555987
96Emphysema (HP:0002097)1.98101848
97Autoimmune hemolytic anemia (HP:0001890)1.96941161
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96188346
99Recurrent pneumonia (HP:0006532)1.96087569
100Spondylolisthesis (HP:0003302)1.94325038
101Esophageal varix (HP:0002040)1.93898515
102Transitional cell carcinoma of the bladder (HP:0006740)1.92394532
103Gingival bleeding (HP:0000225)1.91592402
104Anorexia (HP:0002039)1.90826217
105Gangrene (HP:0100758)1.90205486
106Panhypogammaglobulinemia (HP:0003139)1.87980161
107Dysostosis multiplex (HP:0000943)1.87001791
108Abnormality of glycolipid metabolism (HP:0010969)1.86528426
109Abnormality of liposaccharide metabolism (HP:0010968)1.86528426
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.86528426
111Sepsis (HP:0100806)1.85528423
112Arthralgia (HP:0002829)1.85173450
113Petechiae (HP:0000967)1.85027448
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84542599
115Bladder carcinoma (HP:0002862)1.84489822
116Bladder neoplasm (HP:0009725)1.84489822
117Pulmonary embolism (HP:0002204)1.84450922
118Agammaglobulinemia (HP:0004432)1.84312593
119Skin ulcer (HP:0200042)1.84217124
120Granulocytopenia (HP:0001913)1.84059705
121Axonal loss (HP:0003447)1.83998773
122Absent frontal sinuses (HP:0002688)1.83825231
123Viral hepatitis (HP:0006562)1.83725930
124Conjunctival telangiectasia (HP:0000524)1.83369746
125Hypergammaglobulinemia (HP:0010702)1.83341693
126Purpura (HP:0000979)1.83314704
127Abnormality of B cell number (HP:0010975)1.82059271
128B lymphocytopenia (HP:0010976)1.82059271
129Glomerulopathy (HP:0100820)1.77923886
130Verrucae (HP:0200043)1.74890050
131Papilloma (HP:0012740)1.74890050
132Abnormality of the common coagulation pathway (HP:0010990)1.74421366
133Deep philtrum (HP:0002002)1.73269131
134Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72159011
135Leiomyosarcoma (HP:0100243)1.70115914
136Uterine leiomyosarcoma (HP:0002891)1.70115914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.93689522
2MAP4K13.37459176
3MAP3K143.24856031
4TXK3.06258915
5TYK22.87623978
6TBK12.82024901
7JAK32.81961241
8IRAK32.37040360
9JAK12.29088446
10IKBKE2.27286725
11BMPR22.17009034
12STK102.09572785
13TRIB32.08856873
14CDK121.99514191
15FGFR31.91606075
16IKBKB1.88731574
17EPHB11.88439653
18TAOK31.79179214
19FGFR41.76964424
20KIT1.74828846
21BRD41.74205045
22ITK1.72791471
23ZAP701.70539008
24IRAK41.69700184
25CHUK1.62856229
26TGFBR21.56389648
27BLK1.51739667
28PIM11.49535992
29MAP3K101.48424928
30RPS6KA41.47764385
31EPHA31.45611538
32ERN11.45441377
33RIPK41.44207210
34KSR21.42116337
35HCK1.40335953
36CSK1.35082792
37YES11.31716849
38EIF2AK31.31625673
39CDK61.29859907
40MST41.29775942
41MAP3K11.29127965
42TEC1.28326389
43EEF2K1.25498682
44MAP3K21.24441101
45BTK1.22682593
46LRRK21.22550185
47MARK31.21560067
48LCK1.19961511
49PBK1.18985845
50PTK61.14280103
51PIM21.13593216
52BMX1.12552142
53PKN21.11895871
54SYK1.11833973
55GRK61.11830123
56NEK91.11085343
57JAK21.10764568
58IRAK21.06378985
59CSF1R1.05783780
60PIK3CG1.05042121
61TAOK21.04656077
62ACVR1B0.97704907
63MAP2K30.97131776
64NLK0.96851731
65RIPK10.96613648
66STK40.94561147
67STK30.93653284
68CAMK1D0.91946801
69SIK10.91924025
70MAP3K30.84650672
71NEK60.82017251
72PDGFRB0.80311215
73LYN0.79721103
74DMPK0.78533989
75SGK20.77278052
76KSR10.75795369
77MATK0.74036268
78CDK40.73522306
79EGFR0.72753284
80MAP3K130.71452898
81MAPK70.70720324
82CDK90.70171764
83ALK0.68730311
84SCYL20.68034692
85RET0.62831747
86SMG10.61667193
87SGK30.61245738
88MOS0.60069899
89PRKCQ0.59745620
90SIK20.58610875
91IRAK10.58462022
92PDPK10.57971827
93TRPM70.57320237
94MAP3K80.57148676
95RAF10.56405370
96STK240.56262072
97ABL10.55354094
98MAP3K50.55331417
99TTN0.55121181
100MAP3K60.54023685
101PDGFRA0.51691822
102CAMK1G0.51434163
103GSK3A0.48901862
104FLT30.47833365
105MELK0.47346827
106MAPK120.46220130
107NME20.46181729
108CDC42BPA0.43896100
109TAOK10.42390365
110MAPKAPK20.41751484
111RPS6KA50.41731647
112CLK10.40825997
113MARK20.40441447
114DYRK1B0.39784765
115HIPK20.39593811
116RPS6KL10.37697087
117RPS6KC10.37697087
118MTOR0.37620758
119INSR0.37531383
120PRKCH0.37387699
121IGF1R0.37075638
122NUAK10.36830397
123FGR0.36319657
124PDK10.36108947
125FES0.35542727
126TGFBR10.34053087
127MST1R0.34047532
128SIK30.32195232

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.76161746
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.71177957
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54287138
4Osteoclast differentiation_Homo sapiens_hsa043802.48640521
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31934458
6Measles_Homo sapiens_hsa051622.24223316
7Primary immunodeficiency_Homo sapiens_hsa053402.11749834
8B cell receptor signaling pathway_Homo sapiens_hsa046622.04450752
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.00794516
10Allograft rejection_Homo sapiens_hsa053301.99599888
11Staphylococcus aureus infection_Homo sapiens_hsa051501.89496667
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88474935
13Legionellosis_Homo sapiens_hsa051341.86745622
14Graft-versus-host disease_Homo sapiens_hsa053321.85956828
15TNF signaling pathway_Homo sapiens_hsa046681.82884346
16Toxoplasmosis_Homo sapiens_hsa051451.82402866
17Antigen processing and presentation_Homo sapiens_hsa046121.80856362
18Malaria_Homo sapiens_hsa051441.74841307
19T cell receptor signaling pathway_Homo sapiens_hsa046601.73338268
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71260049
21Influenza A_Homo sapiens_hsa051641.67289375
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.67282121
23Tuberculosis_Homo sapiens_hsa051521.64789099
24Hematopoietic cell lineage_Homo sapiens_hsa046401.59348002
25Pertussis_Homo sapiens_hsa051331.54267349
26Herpes simplex infection_Homo sapiens_hsa051681.53210986
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46226778
28Chronic myeloid leukemia_Homo sapiens_hsa052201.43619432
29Apoptosis_Homo sapiens_hsa042101.43537755
30Asthma_Homo sapiens_hsa053101.43350295
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40255634
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37737555
33Viral myocarditis_Homo sapiens_hsa054161.37277093
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36134113
35Chemokine signaling pathway_Homo sapiens_hsa040621.32572898
36Hepatitis B_Homo sapiens_hsa051611.32407358
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29676833
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29351587
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27314422
40Lysosome_Homo sapiens_hsa041421.24027342
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.22887274
42Acute myeloid leukemia_Homo sapiens_hsa052211.22693575
43Shigellosis_Homo sapiens_hsa051311.21731648
44Pancreatic cancer_Homo sapiens_hsa052121.17298922
45Salmonella infection_Homo sapiens_hsa051321.17167404
46Rheumatoid arthritis_Homo sapiens_hsa053231.13242445
47Hepatitis C_Homo sapiens_hsa051601.13094075
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07897958
49Autoimmune thyroid disease_Homo sapiens_hsa053201.07640643
50Small cell lung cancer_Homo sapiens_hsa052221.04957967
51Prolactin signaling pathway_Homo sapiens_hsa049171.03450273
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.00432062
53Type I diabetes mellitus_Homo sapiens_hsa049400.98255436
54African trypanosomiasis_Homo sapiens_hsa051430.96118367
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.94508586
56Thyroid cancer_Homo sapiens_hsa052160.94367103
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93242237
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91454089
59Viral carcinogenesis_Homo sapiens_hsa052030.91414871
60ErbB signaling pathway_Homo sapiens_hsa040120.87927238
61MicroRNAs in cancer_Homo sapiens_hsa052060.85765929
62HTLV-I infection_Homo sapiens_hsa051660.84810576
63Inositol phosphate metabolism_Homo sapiens_hsa005620.81286334
64Bladder cancer_Homo sapiens_hsa052190.80628706
65Dorso-ventral axis formation_Homo sapiens_hsa043200.80029404
66Epstein-Barr virus infection_Homo sapiens_hsa051690.79683317
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.78539878
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77756824
69Amoebiasis_Homo sapiens_hsa051460.76088547
70Proteoglycans in cancer_Homo sapiens_hsa052050.75626967
71Choline metabolism in cancer_Homo sapiens_hsa052310.75128894
72Nitrogen metabolism_Homo sapiens_hsa009100.73922781
73* Platelet activation_Homo sapiens_hsa046110.73582724
74Renal cell carcinoma_Homo sapiens_hsa052110.72977195
75Phagosome_Homo sapiens_hsa041450.71625163
76Other glycan degradation_Homo sapiens_hsa005110.71234115
77HIF-1 signaling pathway_Homo sapiens_hsa040660.70845611
78* Phospholipase D signaling pathway_Homo sapiens_hsa040720.70112064
79Insulin resistance_Homo sapiens_hsa049310.68849664
80Prostate cancer_Homo sapiens_hsa052150.66944591
81Adherens junction_Homo sapiens_hsa045200.66064752
82GnRH signaling pathway_Homo sapiens_hsa049120.64739761
83mTOR signaling pathway_Homo sapiens_hsa041500.64303309
84Caffeine metabolism_Homo sapiens_hsa002320.63708039
85Notch signaling pathway_Homo sapiens_hsa043300.61868828
86FoxO signaling pathway_Homo sapiens_hsa040680.61354016
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60207978
88Insulin signaling pathway_Homo sapiens_hsa049100.59095740
89Non-small cell lung cancer_Homo sapiens_hsa052230.59057073
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58793215
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58626600
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58488112
93Colorectal cancer_Homo sapiens_hsa052100.58070965
94VEGF signaling pathway_Homo sapiens_hsa043700.57907553
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55733799
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53800209
97Endocytosis_Homo sapiens_hsa041440.52389947
98Estrogen signaling pathway_Homo sapiens_hsa049150.52346221
99Focal adhesion_Homo sapiens_hsa045100.51931488
100* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51679925
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50535798
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.48012017
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46637429
104p53 signaling pathway_Homo sapiens_hsa041150.45904142
105* Sphingolipid signaling pathway_Homo sapiens_hsa040710.45573360
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45410205
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44648065
108Endometrial cancer_Homo sapiens_hsa052130.43876537
109MAPK signaling pathway_Homo sapiens_hsa040100.39814776
110Glioma_Homo sapiens_hsa052140.38743827
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38584748
112Renin-angiotensin system_Homo sapiens_hsa046140.38491253
113Mineral absorption_Homo sapiens_hsa049780.38324188
114Type II diabetes mellitus_Homo sapiens_hsa049300.37691897

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