GNA14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.24119367
2cilium movement (GO:0003341)7.79052015
3negative regulation of complement activation (GO:0045916)7.51739138
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.30315877
5negative regulation of protein activation cascade (GO:2000258)6.91782134
6motile cilium assembly (GO:0044458)6.71515459
7epithelial cilium movement (GO:0003351)6.65324575
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.60440331
9adenosine metabolic process (GO:0046085)6.17028585
10peripheral nervous system neuron development (GO:0048935)6.14086205
11regulation of DNA methylation (GO:0044030)6.03200383
12regulation of acrosome reaction (GO:0060046)5.66159013
13retinal cone cell development (GO:0046549)5.64526403
14detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.31537000
15detection of temperature stimulus involved in sensory perception (GO:0050961)5.31537000
16negative regulation of humoral immune response (GO:0002921)5.02636438
17axoneme assembly (GO:0035082)4.91921546
18multicellular organism reproduction (GO:0032504)4.88222151
19oocyte development (GO:0048599)4.80726147
20meiotic cell cycle (GO:0051321)4.66679249
21negative regulation of dendrite morphogenesis (GO:0050774)4.60287627
22negative regulation of reproductive process (GO:2000242)4.59533243
23detection of temperature stimulus (GO:0016048)4.55345880
24cysteine metabolic process (GO:0006534)4.49665284
25membrane budding (GO:0006900)4.37391298
26purine nucleotide salvage (GO:0032261)4.35720147
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.22322321
28L-phenylalanine metabolic process (GO:0006558)4.22322321
29regulation of histone H3-K9 methylation (GO:0051570)4.20426457
30female gamete generation (GO:0007292)4.16642298
31type B pancreatic cell proliferation (GO:0044342)4.16377415
32L-phenylalanine catabolic process (GO:0006559)4.12989619
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.12989619
34regulation of protein activation cascade (GO:2000257)4.11061177
35regulation of complement activation (GO:0030449)4.08211046
36thrombin receptor signaling pathway (GO:0070493)3.96519908
37neuronal action potential (GO:0019228)3.87025164
38vitamin transmembrane transport (GO:0035461)3.86186118
39regulation of steroid hormone secretion (GO:2000831)3.85277830
40left/right pattern formation (GO:0060972)3.77592825
41sulfur amino acid catabolic process (GO:0000098)3.76248250
42protein kinase C signaling (GO:0070528)3.74429689
43mitotic metaphase plate congression (GO:0007080)3.70762724
44bile acid biosynthetic process (GO:0006699)3.66890628
45left/right axis specification (GO:0070986)3.65250706
46hemidesmosome assembly (GO:0031581)3.61192800
47DNA methylation involved in gamete generation (GO:0043046)3.58847809
48hyperosmotic salinity response (GO:0042538)3.55014055
492-deoxyribonucleotide biosynthetic process (GO:0009265)3.54679470
50deoxyribose phosphate biosynthetic process (GO:0046385)3.54679470
51ethanol oxidation (GO:0006069)3.54326266
52lysine metabolic process (GO:0006553)3.51497642
53lysine catabolic process (GO:0006554)3.51497642
54positive regulation of male gonad development (GO:2000020)3.50303270
55aromatic amino acid family catabolic process (GO:0009074)3.48874681
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45107372
57negative regulation of homotypic cell-cell adhesion (GO:0034111)3.40361260
58positive regulation of histone H3-K4 methylation (GO:0051571)3.36885865
59pyrimidine-containing compound transmembrane transport (GO:0072531)3.36872993
60positive regulation of reproductive process (GO:2000243)3.33822831
61AMP metabolic process (GO:0046033)3.32015116
62coenzyme catabolic process (GO:0009109)3.25141137
63centriole assembly (GO:0098534)3.20618595
64reproduction (GO:0000003)3.19289042
65peroxisome fission (GO:0016559)3.16887554
66potassium ion export (GO:0071435)3.16741884
67labyrinthine layer development (GO:0060711)3.16294325
68intraciliary transport (GO:0042073)3.15605095
69apical protein localization (GO:0045176)3.15532320
70response to water (GO:0009415)3.14400259
71regulation of steroid hormone biosynthetic process (GO:0090030)3.13893121
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13432376
73amino-acid betaine metabolic process (GO:0006577)3.12977452
74positive regulation of megakaryocyte differentiation (GO:0045654)3.12282677
75DNA damage induced protein phosphorylation (GO:0006975)3.12034996
76desmosome organization (GO:0002934)3.10631602
77regulation of meiosis I (GO:0060631)3.10168297
78response to nitrosative stress (GO:0051409)3.09343545
79regulation of RIG-I signaling pathway (GO:0039535)3.06967836
80negative regulation of histone methylation (GO:0031061)3.06504393
81regulation of cholesterol biosynthetic process (GO:0045540)3.06223025
82primitive streak formation (GO:0090009)3.06194110
83ethanol metabolic process (GO:0006067)3.05392663
84nucleotide salvage (GO:0043173)3.04575875
85protein carboxylation (GO:0018214)3.02544966
86peptidyl-glutamic acid carboxylation (GO:0017187)3.02544966
87glyoxylate metabolic process (GO:0046487)3.02244084
88urea metabolic process (GO:0019627)3.01979464
89urea cycle (GO:0000050)3.01979464
90metanephric mesenchyme development (GO:0072075)3.01213352
91response to ATP (GO:0033198)2.99960761
92microtubule bundle formation (GO:0001578)2.99870300
93regulation of female gonad development (GO:2000194)2.99807543
94glomerular epithelial cell development (GO:0072310)2.99572873
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98368799
96negative regulation of coagulation (GO:0050819)2.98319905
97maturation of 5.8S rRNA (GO:0000460)2.97788541
98metaphase plate congression (GO:0051310)2.96541016
99drug transmembrane transport (GO:0006855)2.96521312
100response to pain (GO:0048265)2.96482598
101regulation of cilium movement (GO:0003352)2.95572500
102negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.95196967
103complement activation, classical pathway (GO:0006958)2.92395719
104behavioral response to pain (GO:0048266)2.92262706
105tryptophan catabolic process (GO:0006569)2.91674238
106indole-containing compound catabolic process (GO:0042436)2.91674238
107indolalkylamine catabolic process (GO:0046218)2.91674238
108serine family amino acid catabolic process (GO:0009071)2.90757657
109cytokine production involved in immune response (GO:0002367)2.90689289
110sperm capacitation (GO:0048240)2.90649970
111piRNA metabolic process (GO:0034587)2.89520826
112kynurenine metabolic process (GO:0070189)2.89422316
113establishment of chromosome localization (GO:0051303)2.88693577
114high-density lipoprotein particle remodeling (GO:0034375)2.87175164
115fertilization (GO:0009566)2.86375745
116positive regulation of Cdc42 GTPase activity (GO:0043089)2.85423790
117cytoplasmic microtubule organization (GO:0031122)2.85014738
118nitrogen cycle metabolic process (GO:0071941)2.83183171
119single fertilization (GO:0007338)2.82898109
120negative regulation of hormone biosynthetic process (GO:0032353)2.82872141
121urinary tract smooth muscle contraction (GO:0014848)2.82310323
122negative regulation of meiosis (GO:0045835)2.82299255
123L-amino acid import (GO:0043092)2.81428622
124intestinal cholesterol absorption (GO:0030299)2.81367056
125tryptophan metabolic process (GO:0006568)2.81109038
126alpha-linolenic acid metabolic process (GO:0036109)2.80668139
127centriole replication (GO:0007099)2.80458288
128serine family amino acid metabolic process (GO:0009069)2.79516717
129urate metabolic process (GO:0046415)2.78900780
130ventricular system development (GO:0021591)2.78898389
131binding of sperm to zona pellucida (GO:0007339)2.78840922
132cilium organization (GO:0044782)2.78374164
133protein localization to kinetochore (GO:0034501)2.76621885
134microtubule severing (GO:0051013)2.75708536
135drug catabolic process (GO:0042737)2.71321086
136embryonic foregut morphogenesis (GO:0048617)2.71163075
137glycine metabolic process (GO:0006544)2.70471699
138negative regulation of hormone metabolic process (GO:0032351)2.70433828
139gene silencing by RNA (GO:0031047)2.70026321
140bile acid metabolic process (GO:0008206)2.69889004
141regulation of male gonad development (GO:2000018)2.69348386
142negative regulation of fibrinolysis (GO:0051918)2.68911305
143regulation of reproductive process (GO:2000241)2.68752596
144microtubule-based movement (GO:0007018)2.67851534
145myoblast migration (GO:0051451)2.67604161
146female gonad development (GO:0008585)2.66764323
147serine family amino acid biosynthetic process (GO:0009070)2.66397942
148mitochondrial calcium ion transport (GO:0006851)2.66303980
149establishment or maintenance of bipolar cell polarity (GO:0061245)2.65805340
150establishment or maintenance of apical/basal cell polarity (GO:0035088)2.65805340
151negative regulation of circadian rhythm (GO:0042754)2.65564878
152S-adenosylmethionine metabolic process (GO:0046500)2.64544921
153negative regulation of blood coagulation (GO:0030195)2.64020903
154negative regulation of hemostasis (GO:1900047)2.64020903
155glycine transport (GO:0015816)2.63993671
156cilium assembly (GO:0042384)2.63761421
157N-terminal protein amino acid acetylation (GO:0006474)2.63732829
158aromatic amino acid family metabolic process (GO:0009072)2.63239358
159positive regulation of heart growth (GO:0060421)2.62966175
160homocysteine metabolic process (GO:0050667)2.62899199
161positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.62853174
162regulation of cardioblast differentiation (GO:0051890)2.62721464
163protein complex localization (GO:0031503)2.62215759
164negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.60759667
165benzene-containing compound metabolic process (GO:0042537)2.60467277
166bile acid and bile salt transport (GO:0015721)2.60124463
167regulation of chromatin silencing (GO:0031935)2.59776739
168positive regulation of hormone biosynthetic process (GO:0046886)2.59177026
169regulation of cholesterol metabolic process (GO:0090181)2.58569068
170primary alcohol catabolic process (GO:0034310)2.57834683
171interkinetic nuclear migration (GO:0022027)2.57379986
172fibrinolysis (GO:0042730)2.55927299
173one-carbon metabolic process (GO:0006730)2.55853260
174imidazole-containing compound metabolic process (GO:0052803)2.55616782
175positive regulation of cardiac muscle cell proliferation (GO:0060045)2.54872367
176endoderm development (GO:0007492)2.54579511
177nucleoside salvage (GO:0043174)2.53602433
178regulation of meiosis (GO:0040020)2.52853465
179positive regulation of gastrulation (GO:2000543)2.52429731
180cardiac right ventricle morphogenesis (GO:0003215)2.52341642
181SMAD protein signal transduction (GO:0060395)2.51536917
182long-chain fatty acid biosynthetic process (GO:0042759)2.49541447
183positive regulation of cardiac muscle tissue growth (GO:0055023)2.49470110
184intra-S DNA damage checkpoint (GO:0031573)2.49108553
185regulation of corticosteroid hormone secretion (GO:2000846)2.48547754
186regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.48038243
187cell migration involved in gastrulation (GO:0042074)2.47313584
188gonadal mesoderm development (GO:0007506)2.46791372
189endothelium development (GO:0003158)2.46761947
190embryonic camera-type eye development (GO:0031076)2.46626998
191regulation of cell maturation (GO:1903429)2.45995761
192positive regulation of cell size (GO:0045793)2.44643471
193kidney mesenchyme development (GO:0072074)2.44532950
194mesenchymal to epithelial transition (GO:0060231)2.43872860
195axonemal dynein complex assembly (GO:0070286)10.0389034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.66049110
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.24822707
3ZNF263_19887448_ChIP-Seq_K562_Human4.13582252
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.11283086
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.52879434
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.51988805
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.50187033
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.39035339
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14796348
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.09418052
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85635574
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.71488617
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.67746011
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.62938515
15AR_21909140_ChIP-Seq_LNCAP_Human2.62078571
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51776762
17GATA1_22025678_ChIP-Seq_K562_Human2.49814365
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47496213
19* EP300_21415370_ChIP-Seq_HL-1_Mouse2.34674236
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31156735
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28999747
22VDR_22108803_ChIP-Seq_LS180_Human2.24181300
23* ESR2_21235772_ChIP-Seq_MCF-7_Human2.22672195
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.22659303
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.12486194
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11651071
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10222109
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09267775
29* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.96057502
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92312617
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90204538
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.80734557
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77398302
34* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.73219186
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69694932
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.66294792
37* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65394768
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.64673612
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.64326289
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63961016
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63112807
42* AHR_22903824_ChIP-Seq_MCF-7_Human1.62688619
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59402539
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.59320070
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57217505
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53070373
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.51225524
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49894125
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49407928
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49126314
51ATF3_27146783_Chip-Seq_COLON_Human1.48587254
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.46127811
53* ESR1_21235772_ChIP-Seq_MCF-7_Human1.45998560
54GATA4_25053715_ChIP-Seq_YYC3_Human1.45351508
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44094318
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43119162
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41728613
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.40477843
59* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40177602
60DROSHA_22980978_ChIP-Seq_HELA_Human1.37487173
61GBX2_23144817_ChIP-Seq_PC3_Human1.37445424
62* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35650112
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35393880
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35257475
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35115497
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33895700
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33895700
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33605253
69GATA6_25053715_ChIP-Seq_YYC3_Human1.31760231
70RUNX2_22187159_ChIP-Seq_PCA_Human1.28771484
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28382571
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28019194
73* SOX2_20726797_ChIP-Seq_SW620_Human1.27458728
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26906570
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25965210
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.25030869
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.24177179
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23618204
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21752255
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21752255
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21752255
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21342057
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19732820
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18851110
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18691314
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18508129
87* TP63_23658742_ChIP-Seq_EP156T_Human1.18283881
88* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17648166
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17244048
90TCF4_23295773_ChIP-Seq_U87_Human1.16829999
91TCF4_22108803_ChIP-Seq_LS180_Human1.16379092
92AR_21572438_ChIP-Seq_LNCaP_Human1.13338249
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11969889
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11020822
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10696414
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10463694
97* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10398438
98P300_19829295_ChIP-Seq_ESCs_Human1.10219406
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08756353
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06689110
101* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05250843
102* STAT3_23295773_ChIP-Seq_U87_Human1.05100862
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05045820
104* EWS_26573619_Chip-Seq_HEK293_Human1.03936902
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03813818
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.02858727
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02260537
108* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02243945
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02222291
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01535292
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01000772
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00838993
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00701063
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.00190864
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99926710
116E2F7_22180533_ChIP-Seq_HELA_Human0.99691169
117TP53_18474530_ChIP-ChIP_U2OS_Human0.99674761
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98953996
119CLOCK_20551151_ChIP-Seq_293T_Human0.98827408
120* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97962117
121* AR_25329375_ChIP-Seq_VCAP_Human0.96481233
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96266405
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96214344
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95977644
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95255616
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95032533
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94676731
128GF1_26923725_Chip-Seq_HPCs_Mouse0.94117563
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94094108
130TBL1_22424771_ChIP-Seq_293T_Human0.93660231
131* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92716419
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.92622423
133CBP_21632823_ChIP-Seq_H3396_Human0.92545455
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92113071
135SRF_21415370_ChIP-Seq_HL-1_Mouse0.91844371
136CDX2_22108803_ChIP-Seq_LS180_Human0.91736709
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91127445
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91041192
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90718077
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90410622
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90410622
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90252287
143* FOXA1_25552417_ChIP-Seq_VCAP_Human0.89187605
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.88668211
145TP53_16413492_ChIP-PET_HCT116_Human0.87906160
146SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87406086
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87127470
148EGR1_19032775_ChIP-ChIP_M12_Human0.87024516
149* CBP_20019798_ChIP-Seq_JUKART_Human0.86399796
150* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86399796
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86105900
152* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85339352
153RXR_22108803_ChIP-Seq_LS180_Human0.84606843
154FUS_26573619_Chip-Seq_HEK293_Human0.84497804
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83787819
156BCAT_22108803_ChIP-Seq_LS180_Human0.83515890
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82452633
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82326152
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82202954
160* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81155812
161KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80606952
162ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79631253
163CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79479385
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79251408
165GATA1_26923725_Chip-Seq_HPCs_Mouse0.78585496
166CJUN_26792858_Chip-Seq_BT549_Human0.78466893
167ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77500099
168SMAD_19615063_ChIP-ChIP_OVARY_Human0.76983987
169STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76397949
170* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76376518
171TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76291410
172ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76234998
173MYC_18940864_ChIP-ChIP_HL60_Human0.76179002
174TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76087253
175CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76061023
176XRN2_22483619_ChIP-Seq_HELA_Human0.75641602
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75303183
178FOXM1_23109430_ChIP-Seq_U2OS_Human0.73863230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception5.48093899
2MP0002736_abnormal_nociception_after5.45795196
3MP0002735_abnormal_chemical_nociception4.81920540
4MP0003806_abnormal_nucleotide_metabolis4.72499851
5MP0010368_abnormal_lymphatic_system4.68426654
6MP0002139_abnormal_hepatobiliary_system4.47088583
7MP0001986_abnormal_taste_sensitivity4.45235420
8MP0003890_abnormal_embryonic-extraembry3.74992199
9MP0005360_urolithiasis3.37432366
10MP0005085_abnormal_gallbladder_physiolo3.25846522
11MP0008877_abnormal_DNA_methylation3.00492705
12MP0005365_abnormal_bile_salt2.95340865
13MP0008789_abnormal_olfactory_epithelium2.93225476
14MP0000566_synostosis2.83976020
15MP0002733_abnormal_thermal_nociception2.80152751
16MP0003656_abnormal_erythrocyte_physiolo2.77598187
17MP0003693_abnormal_embryo_hatching2.71149848
18MP0005083_abnormal_biliary_tract2.62516061
19MP0010234_abnormal_vibrissa_follicle2.49295032
20MP0005394_taste/olfaction_phenotype2.44965929
21MP0005499_abnormal_olfactory_system2.44965929
22MP0008875_abnormal_xenobiotic_pharmacok2.33158033
23MP0002734_abnormal_mechanical_nocicepti2.19926531
24MP0003941_abnormal_skin_development2.16470655
25MP0004858_abnormal_nervous_system2.07561659
26MP0004043_abnormal_pH_regulation2.07208827
27MP0005503_abnormal_tendon_morphology2.06490064
28MP0001879_abnormal_lymphatic_vessel2.04729591
29MP0006276_abnormal_autonomic_nervous1.94827973
30MP0009384_cardiac_valve_regurgitation1.94097406
31MP0001970_abnormal_pain_threshold1.92666787
32MP0001666_abnormal_nutrient_absorption1.85831098
33MP0005408_hypopigmentation1.77410876
34MP0004133_heterotaxia1.73375601
35MP0000427_abnormal_hair_cycle1.67942196
36MP0001984_abnormal_olfaction1.67833791
37MP0003195_calcinosis1.66669100
38MP0003186_abnormal_redox_activity1.66038324
39MP0004270_analgesia1.63150483
40MP0003718_maternal_effect1.61214353
41MP0006292_abnormal_olfactory_placode1.57487150
42MP0000579_abnormal_nail_morphology1.55811037
43MP0010329_abnormal_lipoprotein_level1.54961592
44MP0008995_early_reproductive_senescence1.54576086
45MP0008057_abnormal_DNA_replication1.52414079
46MP0000538_abnormal_urinary_bladder1.52373159
47MP0000383_abnormal_hair_follicle1.48969187
48MP0002127_abnormal_cardiovascular_syste1.45880613
49MP0001293_anophthalmia1.45527977
50MP0004957_abnormal_blastocyst_morpholog1.44576635
51MP0003119_abnormal_digestive_system1.43127652
52MP0006138_congestive_heart_failure1.43109184
53MP0003950_abnormal_plasma_membrane1.41619534
54MP0000537_abnormal_urethra_morphology1.40959742
55MP0002653_abnormal_ependyma_morphology1.40530170
56MP0002084_abnormal_developmental_patter1.39610221
57MP0010771_integument_phenotype1.39424808
58MP0003252_abnormal_bile_duct1.38296891
59MP0003868_abnormal_feces_composition1.37717673
60MP0009780_abnormal_chondrocyte_physiolo1.37135405
61MP0002138_abnormal_hepatobiliary_system1.36156949
62MP0002233_abnormal_nose_morphology1.34329030
63MP0009697_abnormal_copulation1.33931138
64MP0002160_abnormal_reproductive_system1.31588982
65MP0005451_abnormal_body_composition1.29606083
66MP0005646_abnormal_pituitary_gland1.29516562
67MP0002168_other_aberrant_phenotype1.28116032
68MP0000049_abnormal_middle_ear1.25401665
69MP0002254_reproductive_system_inflammat1.23319086
70MP0002102_abnormal_ear_morphology1.22913759
71MP0005332_abnormal_amino_acid1.21037608
72MP0001730_embryonic_growth_arrest1.20458587
73MP0000762_abnormal_tongue_morphology1.17041536
74MP0002796_impaired_skin_barrier1.15920800
75MP0003828_pulmonary_edema1.14881150
76MP0004272_abnormal_basement_membrane1.13162660
77MP0005380_embryogenesis_phenotype1.12865143
78MP0001672_abnormal_embryogenesis/_devel1.12865143
79MP0001270_distended_abdomen1.12589203
80MP0002161_abnormal_fertility/fecundity1.10841286
81MP0009379_abnormal_foot_pigmentation1.08580760
82MP0005647_abnormal_sex_gland1.07361236
83MP0005623_abnormal_meninges_morphology1.05902174
84MP0005397_hematopoietic_system_phenotyp1.03854448
85MP0001545_abnormal_hematopoietic_system1.03854448
86MP0005508_abnormal_skeleton_morphology1.00510409
87MP0005389_reproductive_system_phenotype0.99430258
88MP0002277_abnormal_respiratory_mucosa0.98373115
89MP0001145_abnormal_male_reproductive0.97630505
90MP0002108_abnormal_muscle_morphology0.97241065
91MP0002085_abnormal_embryonic_tissue0.97199358
92MP0000609_abnormal_liver_physiology0.96709048
93MP0003937_abnormal_limbs/digits/tail_de0.96575995
94MP0005410_abnormal_fertilization0.96495966
95MP0005220_abnormal_exocrine_pancreas0.96495138
96MP0000631_abnormal_neuroendocrine_gland0.94268714
97MP0000639_abnormal_adrenal_gland0.93918807
98MP0000678_abnormal_parathyroid_gland0.90382268
99MP0003699_abnormal_female_reproductive0.89653392
100MP0004264_abnormal_extraembryonic_tissu0.88617162
101MP0003943_abnormal_hepatobiliary_system0.88033672
102MP0002132_abnormal_respiratory_system0.87739783
103MP0003935_abnormal_craniofacial_develop0.87653254
104MP0002060_abnormal_skin_morphology0.87459408
105MP0009643_abnormal_urine_homeostasis0.86862011
106MP0001119_abnormal_female_reproductive0.86408805
107MP0003879_abnormal_hair_cell0.85739058
108MP0003183_abnormal_peptide_metabolism0.85698445
109MP0002751_abnormal_autonomic_nervous0.85519011
110MP0003453_abnormal_keratinocyte_physiol0.85490758
111MP0004782_abnormal_surfactant_physiolog0.84771610
112MP0010352_gastrointestinal_tract_polyps0.84060609
113MP0002249_abnormal_larynx_morphology0.83668540
114MP0001764_abnormal_homeostasis0.83325779
115MP0008260_abnormal_autophagy0.83048427
116MP0005395_other_phenotype0.82776702
117MP0001756_abnormal_urination0.82365880
118MP0010094_abnormal_chromosome_stability0.81988888
119MP0000767_abnormal_smooth_muscle0.81016628
120MP0005319_abnormal_enzyme/_coenzyme0.80156758
121MP0003724_increased_susceptibility_to0.79795112
122MP0001915_intracranial_hemorrhage0.79709101
123MP0008932_abnormal_embryonic_tissue0.79707605
124MP0008872_abnormal_physiological_respon0.79521403
125MP0000534_abnormal_ureter_morphology0.78003524
126MP0003566_abnormal_cell_adhesion0.77705691
127MP0003698_abnormal_male_reproductive0.76718641
128MP0005636_abnormal_mineral_homeostasis0.76405356
129MP0009840_abnormal_foam_cell0.75979141
130MP0001188_hyperpigmentation0.75696691
131MP0002118_abnormal_lipid_homeostasis0.73586076
132MP0002234_abnormal_pharynx_morphology0.71882647
133MP0000516_abnormal_urinary_system0.71682900
134MP0005367_renal/urinary_system_phenotyp0.71682900
135MP0004019_abnormal_vitamin_homeostasis0.71408514
136MP0002295_abnormal_pulmonary_circulatio0.70978696
137MP0005275_abnormal_skin_tensile0.70519530
138MP0002925_abnormal_cardiovascular_devel0.69019541
139MP0002128_abnormal_blood_circulation0.68380080
140MP0000653_abnormal_sex_gland0.68273021
141MP0005388_respiratory_system_phenotype0.68102425
142MP0002133_abnormal_respiratory_system0.68102425
143MP0000428_abnormal_craniofacial_morphol0.67609687
144MP0003567_abnormal_fetal_cardiomyocyte0.67527046
145MP0005165_increased_susceptibility_to0.66724200
146MP0003984_embryonic_growth_retardation0.66547695
147MP0004085_abnormal_heartbeat0.66531977
148MP0003315_abnormal_perineum_morphology0.66394847
149MP0006036_abnormal_mitochondrial_physio0.65875956
150MP0002088_abnormal_embryonic_growth/wei0.64612337
151MP0003077_abnormal_cell_cycle0.63991485
152MP0003136_yellow_coat_color0.63816362
153MP0000598_abnormal_liver_morphology0.63572461
154MP0001346_abnormal_lacrimal_gland0.62494765
155MP0006054_spinal_hemorrhage0.61911572
156MP0005501_abnormal_skin_physiology0.60681491
157MP0003942_abnormal_urinary_system0.59604944
158MP0009703_decreased_birth_body0.59452916
159MP0001929_abnormal_gametogenesis0.59262038
160MP0010030_abnormal_orbit_morphology0.58666807
161MP0000462_abnormal_digestive_system0.58332855
162MP0004084_abnormal_cardiac_muscle0.57772855
163MP0000372_irregular_coat_pigmentation0.56620798
164MP0005464_abnormal_platelet_physiology0.55917988
165MP0000613_abnormal_salivary_gland0.54410128
166MP0003111_abnormal_nucleus_morphology0.53514432
167MP0000490_abnormal_crypts_of0.53319431
168MP0001849_ear_inflammation0.53047614
169MP0005584_abnormal_enzyme/coenzyme_acti0.52244736
170MP0005187_abnormal_penis_morphology0.49899874
171MP0002210_abnormal_sex_determination0.49830727
172MP0001216_abnormal_epidermal_layer0.49663045
173MP0002282_abnormal_trachea_morphology0.47553227
174MP0010678_abnormal_skin_adnexa0.46340868
175MP0005266_abnormal_metabolism0.45408952
176MP0004147_increased_porphyrin_level0.44563987
177MP0002136_abnormal_kidney_physiology0.44282117

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.99222217
2Absent/shortened dynein arms (HP:0200106)8.13187691
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.13187691
4Abnormal respiratory motile cilium physiology (HP:0012261)8.07402163
5Abnormal ciliary motility (HP:0012262)8.01488652
6Abnormal respiratory motile cilium morphology (HP:0005938)7.91882846
7Abnormal respiratory epithelium morphology (HP:0012253)7.91882846
8Rhinitis (HP:0012384)7.71114340
9Chronic bronchitis (HP:0004469)6.60115462
10Dysautonomia (HP:0002459)5.41326786
11Bronchiectasis (HP:0002110)5.29727859
12Intrahepatic cholestasis (HP:0001406)5.09331363
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.97438432
14Infertility (HP:0000789)4.79518126
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.70472522
16Deep venous thrombosis (HP:0002625)4.62883120
17Abnormality of pain sensation (HP:0010832)3.97229752
18Impaired pain sensation (HP:0007328)3.97229752
19Nasal polyposis (HP:0100582)3.81466738
20Abnormality of methionine metabolism (HP:0010901)3.65898531
21Abnormality of the nasal mucosa (HP:0000433)3.61032860
22Ulnar claw (HP:0001178)3.44340869
23Hyperactive renin-angiotensin system (HP:0000841)3.40131799
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35511033
25Male infertility (HP:0003251)3.31338773
26Abdominal situs inversus (HP:0003363)3.28722833
27Abnormality of abdominal situs (HP:0011620)3.28722833
28Malnutrition (HP:0004395)3.28714102
29Bronchitis (HP:0012387)3.27531512
30Xanthomatosis (HP:0000991)3.12586931
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.11301749
32Hypobetalipoproteinemia (HP:0003563)3.09941741
33Hyperbilirubinemia (HP:0002904)3.08914642
34Gout (HP:0001997)3.07584505
35Abnormality of pyrimidine metabolism (HP:0004353)3.01090910
36Fat malabsorption (HP:0002630)2.98231238
37Hyperammonemia (HP:0001987)2.97523985
38Thyroid carcinoma (HP:0002890)2.90462754
39Neonatal onset (HP:0003623)2.90449541
40Milia (HP:0001056)2.87882855
41Lip pit (HP:0100267)2.83208342
42Supernumerary spleens (HP:0009799)2.81878978
43Hypomagnesemia (HP:0002917)2.77882517
44Abnormal autonomic nervous system physiology (HP:0012332)2.76681505
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.73300487
46Osteomalacia (HP:0002749)2.72446513
47Abnormality of magnesium homeostasis (HP:0004921)2.71569188
48Hand muscle atrophy (HP:0009130)2.70542141
49Tubulointerstitial nephritis (HP:0001970)2.70366503
50Hyperglycinemia (HP:0002154)2.69431218
51Diaphragmatic weakness (HP:0009113)2.66104757
52Autoamputation (HP:0001218)2.65192579
53Hyperglycinuria (HP:0003108)2.64885168
54Papillary thyroid carcinoma (HP:0002895)2.62903812
55Abnormality of fatty-acid metabolism (HP:0004359)2.62781078
56Hypothermia (HP:0002045)2.61760443
57True hermaphroditism (HP:0010459)2.61674203
58Aplastic anemia (HP:0001915)2.59344594
59Occipital encephalocele (HP:0002085)2.59282725
60Steatorrhea (HP:0002570)2.56517378
61Prolonged partial thromboplastin time (HP:0003645)2.52855577
62Muscle fibrillation (HP:0010546)2.45751287
63Tongue fasciculations (HP:0001308)2.44667669
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.44263696
65Stridor (HP:0010307)2.42476766
66Chronic sinusitis (HP:0011109)2.41228223
67Median cleft lip (HP:0000161)2.37556834
68Recurrent sinusitis (HP:0011108)2.35877204
69Nail dystrophy (HP:0008404)2.35285336
70Abnormal gallbladder physiology (HP:0012438)2.34412609
71Cholecystitis (HP:0001082)2.34412609
72Termporal pattern (HP:0011008)2.32240439
73Insidious onset (HP:0003587)2.32240439
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30374715
75Complement deficiency (HP:0004431)2.29677612
76Fragile nails (HP:0001808)2.29264830
77Hypolipoproteinemia (HP:0010981)2.29210189
78Abnormality of serine family amino acid metabolism (HP:0010894)2.29092043
79Abnormality of glycine metabolism (HP:0010895)2.29092043
80Recurrent otitis media (HP:0000403)2.28858110
81Secondary amenorrhea (HP:0000869)2.27064105
82Abnormality of nucleobase metabolism (HP:0010932)2.27031212
83Decreased circulating renin level (HP:0003351)2.25880999
84Cortical dysplasia (HP:0002539)2.25139528
85Carpal bone hypoplasia (HP:0001498)2.24742214
86Chronic hepatic failure (HP:0100626)2.23597174
87Onycholysis (HP:0001806)2.22739622
88Potter facies (HP:0002009)2.22191773
89Facial shape deformation (HP:0011334)2.22191773
90Conjugated hyperbilirubinemia (HP:0002908)2.20319491
91Premature ovarian failure (HP:0008209)2.19975454
92Nausea (HP:0002018)2.19401712
93Abnormality of the intrinsic pathway (HP:0010989)2.18459587
94Brushfield spots (HP:0001088)2.18186028
95Impulsivity (HP:0100710)2.17780627
96Spinal muscular atrophy (HP:0007269)2.16919841
97Segmental peripheral demyelination/remyelination (HP:0003481)2.16642015
98Male pseudohermaphroditism (HP:0000037)2.16151958
99Abnormal hemoglobin (HP:0011902)2.15705483
100Abnormal ventriculo-arterial connection (HP:0011563)2.15658337
101Transposition of the great arteries (HP:0001669)2.15658337
102Abnormal connection of the cardiac segments (HP:0011545)2.15658337
103Spontaneous abortion (HP:0005268)2.14879643
104Hyperlipoproteinemia (HP:0010980)2.13539045
105Bell-shaped thorax (HP:0001591)2.11617628
106Abnormality of the common coagulation pathway (HP:0010990)2.09487481
107Alopecia of scalp (HP:0002293)2.09330029
108Abnormality of lateral ventricle (HP:0030047)2.08466584
109Short nail (HP:0001799)2.08443072
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.06279989
111Plantar hyperkeratosis (HP:0007556)2.05012061
112Overlapping toe (HP:0001845)2.03729270
113Gonadotropin excess (HP:0000837)2.02345747
114Ketosis (HP:0001946)2.00411383
115Abnormality of midbrain morphology (HP:0002418)1.99664239
116Molar tooth sign on MRI (HP:0002419)1.99664239
117Aplasia of the musculature (HP:0100854)1.99141766
118Upper limb amyotrophy (HP:0009129)1.98867754
119Distal upper limb amyotrophy (HP:0007149)1.98867754
120Hypoalphalipoproteinemia (HP:0003233)1.97819792
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97500532
122Atelectasis (HP:0100750)1.97120946
123Hepatocellular carcinoma (HP:0001402)1.95957847
124Oral leukoplakia (HP:0002745)1.91949675
125Acanthocytosis (HP:0001927)1.90901253
126Abnormality of purine metabolism (HP:0004352)1.90001363
127Abnormality of the vocal cords (HP:0008777)1.88468715
128Abnormality of serum amino acid levels (HP:0003112)1.87476564
129Azoospermia (HP:0000027)1.86701289
130Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86326624
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86322993
132Pancreatic fibrosis (HP:0100732)1.85395891
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82710260
134Dicarboxylic aciduria (HP:0003215)1.82710260
135Generalized aminoaciduria (HP:0002909)1.82486705
136Vascular calcification (HP:0004934)1.82166664
137Abnormality of complement system (HP:0005339)1.81565959
138Anencephaly (HP:0002323)1.81418605
139Cone-rod dystrophy (HP:0000548)1.81147578
140Embryonal renal neoplasm (HP:0011794)1.80785624
141Maternal diabetes (HP:0009800)1.80670169
142Abnormality of transition element cation homeostasis (HP:0011030)1.79804678
143Facial hemangioma (HP:0000329)1.78092953
144Anterior segment dysgenesis (HP:0007700)1.77316858
145Abnormal umbilical cord blood vessels (HP:0011403)1.76193661
146Single umbilical artery (HP:0001195)1.76193661
147Abnormality of the fetal cardiovascular system (HP:0010948)1.76193661
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76147435
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76147435
150Delayed CNS myelination (HP:0002188)1.75448131
151Gonadal dysgenesis (HP:0000133)1.75266823
152Abnormal biliary tract physiology (HP:0012439)1.74895603
153Bile duct proliferation (HP:0001408)1.74895603
154Lethargy (HP:0001254)1.74482605
155Pancreatitis (HP:0001733)1.73930823
156Capillary hemangiomas (HP:0005306)1.73514941
157Hyperaldosteronism (HP:0000859)1.73505569
158Testicular neoplasm (HP:0010788)1.72792911
159Curly hair (HP:0002212)1.72513958
160Increased purine levels (HP:0004368)1.72118215
161Hyperuricemia (HP:0002149)1.72118215
162Skin pits (HP:0100276)1.70906447
163Septo-optic dysplasia (HP:0100842)1.67489039
164Bifid tongue (HP:0010297)1.65988483
165Spinal cord compression (HP:0002176)1.65064080
166Postaxial foot polydactyly (HP:0001830)1.64290825
167Preauricular pit (HP:0004467)1.62562784
168Periauricular skin pits (HP:0100277)1.62562784
169Hypoplastic left heart (HP:0004383)1.61924836
170Nephronophthisis (HP:0000090)1.61511613
171Renal salt wasting (HP:0000127)1.61446667
172Abnormality of the dental root (HP:0006486)1.60545808
173Taurodontia (HP:0000679)1.60545808
174Abnormality of permanent molar morphology (HP:0011071)1.60545808
175Anomalous pulmonary venous return (HP:0010772)1.59938802
176Dry hair (HP:0011359)1.59828321
177Bifid scrotum (HP:0000048)1.59795045
178Hyperkalemia (HP:0002153)1.59469034
179Hypoplasia of the fovea (HP:0007750)1.59118095
180Aplasia/Hypoplasia of the fovea (HP:0008060)1.59118095
181Flat acetabular roof (HP:0003180)1.54891584
182Abnormal lung lobation (HP:0002101)1.54187912
183Cystic liver disease (HP:0006706)1.53737942
184Preaxial hand polydactyly (HP:0001177)1.52191249
185Nephroblastoma (Wilms tumor) (HP:0002667)1.51681311
186Abnormality of molar (HP:0011077)1.50737180
187Abnormality of molar morphology (HP:0011070)1.50737180
188Myelomeningocele (HP:0002475)1.48726427
189Congenital hepatic fibrosis (HP:0002612)1.48539355
190Abnormality of the dental pulp (HP:0006479)1.45627200
191Hypophosphatemic rickets (HP:0004912)1.44642254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.48666490
2KSR24.07393428
3MAPK153.59200942
4LATS23.21674443
5MAPKAPK32.96424382
6EEF2K2.73676184
7EPHA22.51992908
8NTRK12.49717047
9PNCK2.41779764
10MATK2.41014159
11MAP3K22.40831484
12ARAF2.38878222
13NEK62.37185681
14MAP3K92.27068840
15KDR2.21349085
16EPHA32.07437538
17BRAF2.06832038
18ERBB42.00448817
19MAP3K61.98241561
20BCKDK1.93219619
21MST1R1.92450363
22STK38L1.86784514
23CAMK1G1.83120335
24RAF11.81971651
25RET1.81654760
26PIM21.75432814
27BRSK21.72547258
28MAP2K21.72279367
29SCYL21.72098143
30MELK1.65664091
31MAP2K11.62177316
32FER1.59828975
33FRK1.57479967
34TNIK1.55561433
35LATS11.52326491
36GRK51.51233046
37TAOK31.48795533
38MARK31.42810498
39NEK91.41804159
40RIPK41.39861269
41LIMK11.39161318
42CAMK1D1.37705998
43RPS6KB21.35971694
44TRIM281.35632447
45MOS1.28500112
46MYLK1.22759582
47LMTK21.20547800
48PRKCI1.20159014
49DMPK1.17951305
50NEK11.14326748
51DYRK21.13304023
52MAP3K121.13055382
53FGFR41.12474780
54CDK81.11889913
55MAP3K11.11110060
56AKT31.10075835
57MUSK1.08297721
58TTK1.07890908
59CDK91.03783158
60TIE10.99807634
61PLK40.97919595
62EIF2AK30.97807481
63TGFBR10.94728607
64TRPM70.91407802
65DAPK20.90140079
66AURKA0.88210572
67TRIB30.87710213
68ACVR1B0.86198467
69PKN20.85172258
70BMPR1B0.85059825
71PINK10.83720338
72MAP3K80.83263005
73TSSK60.82555681
74STK100.82172052
75CSNK1G10.80868097
76PTK2B0.80863229
77MET0.79525061
78MAPKAPK50.78500791
79LRRK20.77762663
80STK390.72615833
81STK30.71222859
82RPS6KA20.70157505
83PRKD30.69858423
84ERBB20.69837939
85NLK0.68048479
86MINK10.66997146
87CDK70.66571761
88JAK20.65997249
89MAP2K40.64341290
90PLK30.63675153
91BRSK10.63340449
92MAP3K130.62445646
93CDK120.61251430
94FLT30.61246328
95KSR10.61174147
96CDC70.60888900
97JAK30.59947616
98CDK60.58808689
99GRK10.57289368
100MAPK110.57212473
101PLK10.57084439
102PIM10.56737051
103SGK20.54601531
104PTK20.54065365
105EIF2AK10.53495543
106VRK10.52969646
107ABL20.51390354
108MAP3K30.51350742
109SGK4940.51156699
110SGK2230.51156699
111ROCK20.50912679
112ERN10.49789463
113PRKG20.49320412
114SMG10.48091527
115ROCK10.47681968
116NME10.47097942
117YES10.45520855
118WEE10.45224368
119ATM0.45052667
120TAOK10.44151079
121PAK60.43762316
122EPHA40.43742097
123SIK30.43714852
124PRKAA20.43540228
125FGFR30.42840606
126STK240.41476981
127AURKB0.40698034
128MAP3K110.40594747
129ERBB30.40553351
130CSNK1G30.40487783
131MKNK20.40392249
132TESK10.39331555
133PBK0.38553151
134MTOR0.38445579
135IGF1R0.38325026
136PAK40.37912585
137MARK20.36965399
138OXSR10.35124235
139PAK10.34906949
140BCR0.34538551
141FGFR20.34161602
142CSNK1D0.32478559
143EGFR0.31876682
144CDK50.31522954
145RIPK10.31474775
146CSNK1G20.31414980
147CAMK10.30778337
148STK380.30272044
149PRKG10.30043669
150PRKCZ0.29931992
151TGFBR20.29639052
152NUAK10.29309066
153CHEK10.29125943
154AKT20.27125713
155WNK10.26837448

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78711548
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.72497584
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88286933
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55539748
5Complement and coagulation cascades_Homo sapiens_hsa046102.42951628
6Thyroid cancer_Homo sapiens_hsa052162.27864784
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27101284
8Fatty acid degradation_Homo sapiens_hsa000712.18187837
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14901443
10Folate biosynthesis_Homo sapiens_hsa007902.07126748
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05494396
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98308952
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98008401
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92928733
15Chemical carcinogenesis_Homo sapiens_hsa052041.92094761
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83848749
17Tryptophan metabolism_Homo sapiens_hsa003801.81918625
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.78958133
19Renin-angiotensin system_Homo sapiens_hsa046141.77778531
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76030416
21Histidine metabolism_Homo sapiens_hsa003401.74801174
22Peroxisome_Homo sapiens_hsa041461.72149628
23Adherens junction_Homo sapiens_hsa045201.69904012
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67397478
25Tight junction_Homo sapiens_hsa045301.67348256
26Caffeine metabolism_Homo sapiens_hsa002321.57584239
27Dorso-ventral axis formation_Homo sapiens_hsa043201.56278161
28Arginine biosynthesis_Homo sapiens_hsa002201.54559929
29Circadian rhythm_Homo sapiens_hsa047101.53618268
30Glycerolipid metabolism_Homo sapiens_hsa005611.52702721
31Propanoate metabolism_Homo sapiens_hsa006401.52656674
32Pyruvate metabolism_Homo sapiens_hsa006201.52236440
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.51146763
34Bile secretion_Homo sapiens_hsa049761.45883065
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.39818165
36beta-Alanine metabolism_Homo sapiens_hsa004101.39586387
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.28764405
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28521758
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25610738
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25040007
41Steroid biosynthesis_Homo sapiens_hsa001001.24243713
42Fatty acid metabolism_Homo sapiens_hsa012121.20325673
43Retinol metabolism_Homo sapiens_hsa008301.20222959
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16145603
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15947898
46Mismatch repair_Homo sapiens_hsa034301.15905245
47Cell cycle_Homo sapiens_hsa041101.14354414
48ECM-receptor interaction_Homo sapiens_hsa045121.10506695
49Glutathione metabolism_Homo sapiens_hsa004801.08054737
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07916621
51Fat digestion and absorption_Homo sapiens_hsa049751.07749750
52Tyrosine metabolism_Homo sapiens_hsa003501.05509037
53Phenylalanine metabolism_Homo sapiens_hsa003601.05119309
54Sphingolipid metabolism_Homo sapiens_hsa006001.01907334
55Butanoate metabolism_Homo sapiens_hsa006501.00537014
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00354466
57Nucleotide excision repair_Homo sapiens_hsa034200.99731548
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98448002
59Vitamin B6 metabolism_Homo sapiens_hsa007500.97590710
60Selenocompound metabolism_Homo sapiens_hsa004500.96567356
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95223544
62PPAR signaling pathway_Homo sapiens_hsa033200.94321774
63Biosynthesis of amino acids_Homo sapiens_hsa012300.93372352
64Base excision repair_Homo sapiens_hsa034100.92266209
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.90956049
66Pancreatic secretion_Homo sapiens_hsa049720.90577345
67Hippo signaling pathway_Homo sapiens_hsa043900.90086205
68Sulfur relay system_Homo sapiens_hsa041220.89972341
69Bladder cancer_Homo sapiens_hsa052190.87915014
70Linoleic acid metabolism_Homo sapiens_hsa005910.87597793
71One carbon pool by folate_Homo sapiens_hsa006700.87295817
72Wnt signaling pathway_Homo sapiens_hsa043100.87230816
73Gap junction_Homo sapiens_hsa045400.84113611
74Protein digestion and absorption_Homo sapiens_hsa049740.83866255
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83718327
76Starch and sucrose metabolism_Homo sapiens_hsa005000.82290362
77Inositol phosphate metabolism_Homo sapiens_hsa005620.78180216
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76788703
79Endometrial cancer_Homo sapiens_hsa052130.76716082
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76553688
81Nitrogen metabolism_Homo sapiens_hsa009100.76085960
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75763491
83Sulfur metabolism_Homo sapiens_hsa009200.72409382
84Rap1 signaling pathway_Homo sapiens_hsa040150.70068697
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69698202
86Notch signaling pathway_Homo sapiens_hsa043300.69249200
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68991350
88Olfactory transduction_Homo sapiens_hsa047400.67980280
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67685733
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.67017542
91Vitamin digestion and absorption_Homo sapiens_hsa049770.66699968
92Arginine and proline metabolism_Homo sapiens_hsa003300.66329902
93Focal adhesion_Homo sapiens_hsa045100.66177287
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66058939
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65887720
96Pyrimidine metabolism_Homo sapiens_hsa002400.65835088
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64970281
98Carbon metabolism_Homo sapiens_hsa012000.64596033
99Prolactin signaling pathway_Homo sapiens_hsa049170.61741691
100Huntingtons disease_Homo sapiens_hsa050160.61503325
101Hedgehog signaling pathway_Homo sapiens_hsa043400.60434936
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.59740444
103RNA polymerase_Homo sapiens_hsa030200.59624053
104TGF-beta signaling pathway_Homo sapiens_hsa043500.58839426
105mRNA surveillance pathway_Homo sapiens_hsa030150.58807709
106RNA degradation_Homo sapiens_hsa030180.58613721
107Melanoma_Homo sapiens_hsa052180.56653957
108Melanogenesis_Homo sapiens_hsa049160.56372054
109Prostate cancer_Homo sapiens_hsa052150.56193988
110cAMP signaling pathway_Homo sapiens_hsa040240.56100935
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55885188
112Serotonergic synapse_Homo sapiens_hsa047260.55611176
113Axon guidance_Homo sapiens_hsa043600.54001905
114Fatty acid elongation_Homo sapiens_hsa000620.53706924
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53289410
116Taste transduction_Homo sapiens_hsa047420.52952647
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52856711
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52180054
119p53 signaling pathway_Homo sapiens_hsa041150.52012137
120Ovarian steroidogenesis_Homo sapiens_hsa049130.51894260
121Oocyte meiosis_Homo sapiens_hsa041140.50394559
122Proteoglycans in cancer_Homo sapiens_hsa052050.49593249
123Basal cell carcinoma_Homo sapiens_hsa052170.49518442
124Choline metabolism in cancer_Homo sapiens_hsa052310.49124296
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48819554
126Pentose phosphate pathway_Homo sapiens_hsa000300.48234987
127ABC transporters_Homo sapiens_hsa020100.47597859
128Proteasome_Homo sapiens_hsa030500.46028908
129Metabolic pathways_Homo sapiens_hsa011000.45437105
130Long-term depression_Homo sapiens_hsa047300.44185088
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43340997
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42400681
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.42294100
134Basal transcription factors_Homo sapiens_hsa030220.41893187
135Phototransduction_Homo sapiens_hsa047440.41510212
136Arachidonic acid metabolism_Homo sapiens_hsa005900.41470716
137Nicotine addiction_Homo sapiens_hsa050330.41322238
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41243298
139Ribosome_Homo sapiens_hsa030100.41072683
140mTOR signaling pathway_Homo sapiens_hsa041500.39768843
141Mineral absorption_Homo sapiens_hsa049780.39487254
142Regulation of autophagy_Homo sapiens_hsa041400.38647321
143Ras signaling pathway_Homo sapiens_hsa040140.38472764
144Dilated cardiomyopathy_Homo sapiens_hsa054140.38177722
145Non-homologous end-joining_Homo sapiens_hsa034500.37597250
146Pancreatic cancer_Homo sapiens_hsa052120.37287886
147Fanconi anemia pathway_Homo sapiens_hsa034600.36658287
148RNA transport_Homo sapiens_hsa030130.33590244
149DNA replication_Homo sapiens_hsa030300.31958245
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31927251
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.31393957
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30836469

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