GNAQP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)6.34253531
2L-fucose metabolic process (GO:0042354)6.34253531
3L-fucose catabolic process (GO:0042355)6.34253531
4growth hormone receptor signaling pathway (GO:0060396)6.33868902
5neuronal action potential propagation (GO:0019227)5.84856545
6cellular response to growth hormone stimulus (GO:0071378)5.64219214
7regulation of synapse structural plasticity (GO:0051823)5.64016947
8cell fate commitment involved in formation of primary germ layer (GO:0060795)5.15913609
9positive regulation of T-helper 1 type immune response (GO:0002827)4.73970705
10negative regulation of mast cell activation (GO:0033004)4.58853058
11histone H2A acetylation (GO:0043968)4.39779480
12RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.37669381
13phosphatidylinositol acyl-chain remodeling (GO:0036149)4.27610744
14mast cell activation involved in immune response (GO:0002279)4.21727602
15mast cell degranulation (GO:0043303)4.21727602
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.10132221
17chaperone mediated protein folding requiring cofactor (GO:0051085)3.94857952
18dendritic spine morphogenesis (GO:0060997)3.89216124
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.86349392
20DNA deamination (GO:0045006)3.82983665
21immunoglobulin mediated immune response (GO:0016064)3.80404002
22response to pheromone (GO:0019236)3.70452479
23ubiquinone biosynthetic process (GO:0006744)3.63670690
24negative regulation of JAK-STAT cascade (GO:0046426)3.61521021
25prepulse inhibition (GO:0060134)3.58966969
26positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.55247578
27lysine metabolic process (GO:0006553)3.46680056
28lysine catabolic process (GO:0006554)3.46680056
29positive regulation of response to oxidative stress (GO:1902884)3.45166265
30positive regulation of cellular response to oxidative stress (GO:1900409)3.45166265
31regulation of oxidative stress-induced neuron death (GO:1903203)3.44556547
32negative regulation of telomere maintenance (GO:0032205)3.44459237
33L-methionine salvage (GO:0071267)3.42937163
34L-methionine biosynthetic process (GO:0071265)3.42937163
35amino acid salvage (GO:0043102)3.42937163
36hindbrain development (GO:0030902)3.40603045
37autophagic vacuole fusion (GO:0000046)3.25009692
38protein-cofactor linkage (GO:0018065)3.24281574
39ubiquinone metabolic process (GO:0006743)3.24191137
40negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.23393264
41regulation of T-helper 1 type immune response (GO:0002825)3.22595221
42phosphatidylserine acyl-chain remodeling (GO:0036150)3.20220412
43heme transport (GO:0015886)3.19152420
44lysosome localization (GO:0032418)3.13836654
45positive regulation of hormone biosynthetic process (GO:0046886)3.13383705
46protein neddylation (GO:0045116)3.06501820
47B cell mediated immunity (GO:0019724)3.01851619
48phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.98464378
49response to growth hormone (GO:0060416)2.97158480
50interleukin-6-mediated signaling pathway (GO:0070102)2.95218409
51organelle membrane fusion (GO:0090174)2.94772804
52UTP metabolic process (GO:0046051)2.94228305
53positive regulation of antigen processing and presentation (GO:0002579)2.93547747
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91874818
55regulation of T-helper 1 cell differentiation (GO:0045625)2.91777770
56auditory behavior (GO:0031223)2.90624436
57aspartate family amino acid catabolic process (GO:0009068)2.90110158
58neurotransmitter catabolic process (GO:0042135)2.88752290
59piRNA metabolic process (GO:0034587)2.88026107
60GTP biosynthetic process (GO:0006183)2.84410258
61fusion of sperm to egg plasma membrane (GO:0007342)2.84204022
62regulation of integrin activation (GO:0033623)2.83135195
63negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.79814087
64negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.78550757
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78490710
66phosphatidylcholine acyl-chain remodeling (GO:0036151)2.77845575
67quinone biosynthetic process (GO:1901663)2.73606033
68sleep (GO:0030431)2.70794503
69phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.67821972
70S-adenosylmethionine metabolic process (GO:0046500)2.67761938
71alanine transport (GO:0032328)2.65692336
72auditory receptor cell stereocilium organization (GO:0060088)2.64030876
73regulation of antigen processing and presentation (GO:0002577)2.63118192
74fatty acid transmembrane transport (GO:1902001)2.62625976
75platelet dense granule organization (GO:0060155)2.62128823
76nonribosomal peptide biosynthetic process (GO:0019184)2.61437272
77maturation of 5.8S rRNA (GO:0000460)2.61188613
78somite development (GO:0061053)2.59987760
79glutathione biosynthetic process (GO:0006750)2.59879816
80cullin deneddylation (GO:0010388)2.58942039
81glomerular visceral epithelial cell development (GO:0072015)2.57722612
82response to interferon-beta (GO:0035456)2.57641270
83midbrain development (GO:0030901)2.56310987
84neuromuscular process controlling posture (GO:0050884)2.56245255
85negative regulation by host of viral transcription (GO:0043922)2.55221517
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54936355
87ATP synthesis coupled proton transport (GO:0015986)2.54936355
88mast cell activation (GO:0045576)2.53978762
89regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53792018
90fucosylation (GO:0036065)2.53512718
91negative regulation of reactive oxygen species metabolic process (GO:2000378)2.53401628
92methionine biosynthetic process (GO:0009086)2.52247152
93positive thymic T cell selection (GO:0045059)2.51455766
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50511610
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.50511610
96regulation of translation, ncRNA-mediated (GO:0045974)2.50511610
97regulation of meiosis I (GO:0060631)2.49774325
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49183759
99cell migration in hindbrain (GO:0021535)2.49045274
100negative regulation of B cell apoptotic process (GO:0002903)2.48903630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.16500660
2ZNF274_21170338_ChIP-Seq_K562_Hela3.09221532
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87369438
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.75617209
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59078642
6GBX2_23144817_ChIP-Seq_PC3_Human2.58121218
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.33411992
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32469268
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32190048
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17131781
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15212384
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14859382
13ER_23166858_ChIP-Seq_MCF-7_Human2.06841291
14EWS_26573619_Chip-Seq_HEK293_Human2.05852004
15YY1_21170310_ChIP-Seq_MESCs_Mouse2.01919857
16MYC_18940864_ChIP-ChIP_HL60_Human1.98195017
17RNF2_27304074_Chip-Seq_NSC_Mouse1.91253315
18FUS_26573619_Chip-Seq_HEK293_Human1.88188640
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.85362254
20CBP_20019798_ChIP-Seq_JUKART_Human1.85362254
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.84949380
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82999173
23IRF1_19129219_ChIP-ChIP_H3396_Human1.81169500
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80582069
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78186536
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75655360
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74533749
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73630735
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69762441
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.65817687
31P300_19829295_ChIP-Seq_ESCs_Human1.62872401
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58812546
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58122035
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53632675
35EZH2_22144423_ChIP-Seq_EOC_Human1.48853405
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47669463
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44768213
38AR_20517297_ChIP-Seq_VCAP_Human1.43419225
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43189480
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42466550
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42466550
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.41505382
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40710117
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34936620
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34241217
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33288707
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32471033
48TP53_22573176_ChIP-Seq_HFKS_Human1.31718820
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28655545
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28357142
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.28137823
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25676773
53AR_25329375_ChIP-Seq_VCAP_Human1.25541456
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25527739
55ELK1_19687146_ChIP-ChIP_HELA_Human1.25451849
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.23504139
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22833783
58TAF2_19829295_ChIP-Seq_ESCs_Human1.21915730
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20869851
60BCAT_22108803_ChIP-Seq_LS180_Human1.20599924
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20019969
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.17736448
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.16722500
64IGF1R_20145208_ChIP-Seq_DFB_Human1.14584416
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.14523831
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13007915
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12321519
68SOX2_19829295_ChIP-Seq_ESCs_Human1.12321519
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.11655761
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11655761
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10889689
72VDR_23849224_ChIP-Seq_CD4+_Human1.10840183
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09448111
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08456454
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08154736
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.06923962
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05768632
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04468426
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.04262909
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04137619
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04077523
82REST_21632747_ChIP-Seq_MESCs_Mouse1.03435667
83MYC_19829295_ChIP-Seq_ESCs_Human1.02419646
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02121312
85CIITA_25753668_ChIP-Seq_RAJI_Human1.01850565
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00582088
87AR_21572438_ChIP-Seq_LNCaP_Human0.99867028
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98944372
89HOXB7_26014856_ChIP-Seq_BT474_Human0.98030635
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97975113
91TAF15_26573619_Chip-Seq_HEK293_Human0.97410486
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96626605
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.96594827
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.95454460
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93943339
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92697832
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.91816881
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91484611
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90506129
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.89304395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system7.95248547
2MP0003136_yellow_coat_color4.62904490
3MP0002653_abnormal_ependyma_morphology3.59935359
4MP0005645_abnormal_hypothalamus_physiol3.35731972
5MP0004885_abnormal_endolymph3.04128754
6MP0000613_abnormal_salivary_gland2.61759503
7MP0005646_abnormal_pituitary_gland2.54186107
8MP0003724_increased_susceptibility_to2.51480413
9MP0003646_muscle_fatigue2.38859352
10MP0005410_abnormal_fertilization2.15535134
11MP0002938_white_spotting2.07481881
12MP0008872_abnormal_physiological_respon2.06884344
13MP0009780_abnormal_chondrocyte_physiolo2.06316011
14MP0005167_abnormal_blood-brain_barrier1.95662509
15MP0000569_abnormal_digit_pigmentation1.81689590
16MP0001835_abnormal_antigen_presentation1.76195502
17MP0002277_abnormal_respiratory_mucosa1.69793520
18MP0003638_abnormal_response/metabolism_1.69634499
19MP0005171_absent_coat_pigmentation1.66115487
20MP0002733_abnormal_thermal_nociception1.66100618
21MP0002254_reproductive_system_inflammat1.65515033
22MP0001968_abnormal_touch/_nociception1.63334552
23MP0005084_abnormal_gallbladder_morpholo1.62547970
24MP0002166_altered_tumor_susceptibility1.49953190
25MP0002837_dystrophic_cardiac_calcinosis1.49732887
26MP0001243_abnormal_dermal_layer1.49072829
27MP0009278_abnormal_bone_marrow1.48588040
28MP0006072_abnormal_retinal_apoptosis1.43491089
29MP0002751_abnormal_autonomic_nervous1.42740090
30MP0006138_congestive_heart_failure1.41878506
31MP0003718_maternal_effect1.36863628
32MP0005503_abnormal_tendon_morphology1.36308686
33MP0001485_abnormal_pinna_reflex1.35305292
34MP0006276_abnormal_autonomic_nervous1.33590057
35MP0004142_abnormal_muscle_tone1.32459041
36MP0006292_abnormal_olfactory_placode1.31994189
37MP0001440_abnormal_grooming_behavior1.28794311
38MP0008775_abnormal_heart_ventricle1.28068667
39MP0004133_heterotaxia1.26520433
40MP0002102_abnormal_ear_morphology1.23457242
41MP0000631_abnormal_neuroendocrine_gland1.22530968
42MP0002638_abnormal_pupillary_reflex1.17059226
43MP0002272_abnormal_nervous_system1.16230388
44MP0009046_muscle_twitch1.16024450
45MP0002006_tumorigenesis1.15784177
46MP0000013_abnormal_adipose_tissue1.13552901
47MP0002909_abnormal_adrenal_gland1.13517289
48MP0001970_abnormal_pain_threshold1.06421963
49MP0003283_abnormal_digestive_organ1.06140551
50MP0004742_abnormal_vestibular_system1.04462689
51MP0002067_abnormal_sensory_capabilities1.02348624
52MP0000647_abnormal_sebaceous_gland1.01212038
53MP0000372_irregular_coat_pigmentation1.00058237
54MP0005551_abnormal_eye_electrophysiolog0.99986280
55MP0000465_gastrointestinal_hemorrhage0.98151339
56MP0004084_abnormal_cardiac_muscle0.96194210
57MP0001663_abnormal_digestive_system0.93932857
58MP0002876_abnormal_thyroid_physiology0.92968462
59MP0005253_abnormal_eye_physiology0.91815855
60MP0001905_abnormal_dopamine_level0.89378679
61MP0001984_abnormal_olfaction0.86947779
62MP0003011_delayed_dark_adaptation0.86422185
63MP0002064_seizures0.83808673
64MP0002148_abnormal_hypersensitivity_rea0.83345354
65MP0004043_abnormal_pH_regulation0.81599231
66MP0009745_abnormal_behavioral_response0.79063276
67MP0005220_abnormal_exocrine_pancreas0.78970980
68MP0002735_abnormal_chemical_nociception0.78684118
69MP0002734_abnormal_mechanical_nocicepti0.77944183
70MP0005671_abnormal_response_to0.77172947
71MP0005187_abnormal_penis_morphology0.76879652
72MP0004134_abnormal_chest_morphology0.76147579
73MP0002557_abnormal_social/conspecific_i0.75146768
74MP0000230_abnormal_systemic_arterial0.73406154
75MP0002572_abnormal_emotion/affect_behav0.73388288
76MP0005595_abnormal_vascular_smooth0.71103422
77MP0005390_skeleton_phenotype0.70572290
78MP0003635_abnormal_synaptic_transmissio0.69621569
79MP0001529_abnormal_vocalization0.68718896
80MP0009697_abnormal_copulation0.68272222
81MP0003122_maternal_imprinting0.66471375
82MP0005508_abnormal_skeleton_morphology0.65577070
83MP0005174_abnormal_tail_pigmentation0.64866166
84MP0001486_abnormal_startle_reflex0.64582876
85MP0008873_increased_physiological_sensi0.64457385
86MP0002127_abnormal_cardiovascular_syste0.63501509
87MP0002282_abnormal_trachea_morphology0.60535339
88MP0010368_abnormal_lymphatic_system0.60292527
89MP0002108_abnormal_muscle_morphology0.59505913
90MP0004036_abnormal_muscle_relaxation0.59498057
91MP0004924_abnormal_behavior0.59496638
92MP0005386_behavior/neurological_phenoty0.59496638
93MP0001929_abnormal_gametogenesis0.59357472
94MP0005381_digestive/alimentary_phenotyp0.59198145
95MP0002736_abnormal_nociception_after0.58906433
96MP0010329_abnormal_lipoprotein_level0.57824538
97MP0003045_fibrosis0.57170416
98MP0001533_abnormal_skeleton_physiology0.56744533
99MP0003195_calcinosis0.56695833
100MP0004145_abnormal_muscle_electrophysio0.55524792

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.53672084
2Molar tooth sign on MRI (HP:0002419)4.50792811
3Abnormality of midbrain morphology (HP:0002418)4.50792811
4Retinal dysplasia (HP:0007973)3.82248264
5Congenital, generalized hypertrichosis (HP:0004540)3.63032799
6Hemiparesis (HP:0001269)3.62583061
7Bifid tongue (HP:0010297)3.47159286
8Abnormal number of erythroid precursors (HP:0012131)3.44730556
9Abnormality of the prostate (HP:0008775)3.42088828
10Attenuation of retinal blood vessels (HP:0007843)3.41386469
11Hypomagnesemia (HP:0002917)3.35014679
12Mesangial abnormality (HP:0001966)3.21168728
13Abolished electroretinogram (ERG) (HP:0000550)3.17028129
14Hypoproteinemia (HP:0003075)3.13789975
15Fair hair (HP:0002286)3.13596619
16True hermaphroditism (HP:0010459)3.09657726
17Abnormality of secondary sexual hair (HP:0009888)3.07611411
18Abnormality of the axillary hair (HP:0100134)3.07611411
19Bilateral microphthalmos (HP:0007633)3.01900497
20Ulnar claw (HP:0001178)2.98141138
21Congenital stationary night blindness (HP:0007642)2.94439903
22Hypochromic microcytic anemia (HP:0004840)2.93125492
23Midline defect of the nose (HP:0004122)2.92201755
24Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.84315390
25Broad-based gait (HP:0002136)2.77327164
26J-shaped sella turcica (HP:0002680)2.75669694
27Failure to thrive in infancy (HP:0001531)2.73059292
28Tongue fasciculations (HP:0001308)2.72138294
29Abnormality of cells of the erythroid lineage (HP:0012130)2.63699327
30Pancreatic fibrosis (HP:0100732)2.57719619
31Lipid accumulation in hepatocytes (HP:0006561)2.57233617
32Bilateral sensorineural hearing impairment (HP:0008619)2.57108776
33Abnormality of the diencephalon (HP:0010662)2.54617718
34Progressive inability to walk (HP:0002505)2.47685110
35Panhypogammaglobulinemia (HP:0003139)2.45595867
36Abnormality of magnesium homeostasis (HP:0004921)2.44849075
37Type 2 muscle fiber atrophy (HP:0003554)2.37589954
38Dry hair (HP:0011359)2.35648623
39Deformed sella turcica (HP:0002681)2.34136211
40Stomach cancer (HP:0012126)2.32074753
41Gaze-evoked nystagmus (HP:0000640)2.30949940
42Febrile seizures (HP:0002373)2.30337121
43Type II lissencephaly (HP:0007260)2.29466142
44Sclerocornea (HP:0000647)2.28822355
45Cerebellar dysplasia (HP:0007033)2.24812214
46Large for gestational age (HP:0001520)2.24436753
47Ridged nail (HP:0001807)2.24362405
48Inability to walk (HP:0002540)2.23142562
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22471971
50Abnormal protein N-linked glycosylation (HP:0012347)2.22471971
51Abnormal protein glycosylation (HP:0012346)2.22471971
52Abnormal glycosylation (HP:0012345)2.22471971
53Supernumerary bones of the axial skeleton (HP:0009144)2.22184638
54Pancreatic cysts (HP:0001737)2.20827551
55Muscle fibrillation (HP:0010546)2.17908269
56Pachygyria (HP:0001302)2.16932263
57Cystic liver disease (HP:0006706)2.13661277
58Increased hepatocellular lipid droplets (HP:0006565)2.12723211
59Abnormality of male internal genitalia (HP:0000022)2.11470820
60Severe muscular hypotonia (HP:0006829)2.10851063
61Abnormal rod and cone electroretinograms (HP:0008323)2.07429663
62Abnormality of the vocal cords (HP:0008777)2.07308498
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05348412
64Generalized hypopigmentation of hair (HP:0011358)2.02050094
65Focal motor seizures (HP:0011153)2.01476894
66Polyuria (HP:0000103)2.01451775
67Spastic tetraparesis (HP:0001285)1.99767888
68Abnormality of the pons (HP:0007361)1.96502872
69Hyperglycinuria (HP:0003108)1.94968267
70Aplasia/Hypoplasia of the sternum (HP:0006714)1.94602666
71Muscle fiber atrophy (HP:0100295)1.93586572
72Nephronophthisis (HP:0000090)1.91909278
73Abnormality of the renal medulla (HP:0100957)1.89696539
74Neonatal respiratory distress (HP:0002643)1.89497562
75Gastrointestinal atresia (HP:0002589)1.86819650
76Hypothermia (HP:0002045)1.86571336
77Abnormality of the sella turcica (HP:0002679)1.85941507
78Aplasia/Hypoplasia of the fibula (HP:0006492)1.85075849
79Acute necrotizing encephalopathy (HP:0006965)1.85015361
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81204648
81Facial diplegia (HP:0001349)1.80852693
82Generalized aminoaciduria (HP:0002909)1.80847965
83Fibular aplasia (HP:0002990)1.79517791
84Hypokalemic alkalosis (HP:0001949)1.78571266
853-Methylglutaconic aciduria (HP:0003535)1.75593207
86Hypochromic anemia (HP:0001931)1.75560141
87Optic nerve hypoplasia (HP:0000609)1.75298875
88Anencephaly (HP:0002323)1.73046135
89Abnormal finger flexion creases (HP:0006143)1.72868993
90Abnormality of the renal cortex (HP:0011035)1.72834944
91Megalocornea (HP:0000485)1.71241072
92Absent phalangeal crease (HP:0006109)1.70999627
93Mitochondrial inheritance (HP:0001427)1.70955297
94Hepatic necrosis (HP:0002605)1.69586634
95Rectal fistula (HP:0100590)1.69372854
96Rectovaginal fistula (HP:0000143)1.69372854
97Metabolic alkalosis (HP:0200114)1.69369225
98Hepatocellular necrosis (HP:0001404)1.68505305
99Short tibia (HP:0005736)1.68161161
100Neoplasm of the adrenal cortex (HP:0100641)1.66701777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B6.89179918
2CDK84.25615658
3CAMK1D4.20606836
4CAMK1G3.79973840
5TLK13.38702453
6PNCK3.17695839
7KIT3.14391023
8ZAK3.10040813
9CAMKK22.80847348
10TGFBR12.61879730
11TSSK62.10273146
12WNK31.95460289
13MAPKAPK51.90238355
14PLK21.87696171
15MKNK11.85085992
16GRK11.72790695
17PHKG11.71620705
18PHKG21.71620705
19CDK191.59533926
20TAOK31.57334058
21BCKDK1.56812449
22FRK1.39465185
23CAMKK11.36234865
24VRK11.30376985
25MET1.27436877
26VRK21.23836746
27MAP4K11.23641475
28ADRBK21.06244698
29FLT31.03116945
30CAMK11.02008491
31MAPK151.00348407
32GRK60.99079301
33SYK0.94162623
34FER0.93764019
35NUAK10.88792472
36CDK90.87846236
37OXSR10.84413180
38RIPK40.84103352
39MAPK130.82903088
40CSF1R0.82672490
41INSRR0.81943225
42CDK30.81045765
43KDR0.78116615
44CAMK40.77177930
45SCYL20.73711788
46EPHB20.69936883
47TYRO30.69752978
48RPS6KA50.67146329
49PLK30.67058067
50MAP4K20.63794179
51DAPK20.56509722
52PTK2B0.52470931
53MAPKAPK30.50850357
54MAP2K20.47372665
55TNK20.47180917
56OBSCN0.46428680
57PRKCE0.43813761
58CSNK1G10.43693220
59WNK40.43199173
60GRK70.41954329
61NTRK10.40813979
62FES0.39048039
63PRKCI0.37948141
64STK30.37310796
65MKNK20.36931532
66STK160.35637273
67IKBKB0.34728195
68CSNK1G30.34476694
69LYN0.33909562
70PIK3CA0.33475886
71TEC0.33183609
72RPS6KA40.32585563
73CSNK1G20.31252176
74MATK0.30697111
75CASK0.29830727
76CDK70.29664923
77ATR0.28598690
78BRD40.27434145
79IKBKE0.26385781
80TRPM70.25908351
81EGFR0.25695108
82TIE10.25317615
83SRPK10.25300777
84ABL10.24254581
85ADRBK10.24172223
86STK240.24115736
87PINK10.22800151
88ATM0.22385531
89WNK10.20848102
90PRKCQ0.20365652
91CDC70.20227770
92EPHB10.19068609
93NEK60.18726000
94CAMK2A0.18139338
95CAMK2D0.17424959
96ERBB30.17226194
97TBK10.16423797
98ITK0.15668821
99IGF1R0.14777107
100PRKCA0.14470237

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.34237740
2Allograft rejection_Homo sapiens_hsa053304.02741997
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.80619912
4Autoimmune thyroid disease_Homo sapiens_hsa053203.67168916
5Graft-versus-host disease_Homo sapiens_hsa053323.64671551
6Type I diabetes mellitus_Homo sapiens_hsa049403.48746034
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.83946804
8Antigen processing and presentation_Homo sapiens_hsa046122.80113368
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58348829
10Linoleic acid metabolism_Homo sapiens_hsa005912.57251991
11Systemic lupus erythematosus_Homo sapiens_hsa053222.19184631
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17368860
13Staphylococcus aureus infection_Homo sapiens_hsa051502.00184909
14Oxidative phosphorylation_Homo sapiens_hsa001901.98271657
15Selenocompound metabolism_Homo sapiens_hsa004501.93304062
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.91792225
17Parkinsons disease_Homo sapiens_hsa050121.79107514
18Rheumatoid arthritis_Homo sapiens_hsa053231.77178011
19Viral myocarditis_Homo sapiens_hsa054161.75703888
20Ether lipid metabolism_Homo sapiens_hsa005651.75416765
21Leishmaniasis_Homo sapiens_hsa051401.62323173
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54829308
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39434529
24Phototransduction_Homo sapiens_hsa047441.32111107
25Nitrogen metabolism_Homo sapiens_hsa009101.25466433
26Arachidonic acid metabolism_Homo sapiens_hsa005901.25317083
27Cardiac muscle contraction_Homo sapiens_hsa042601.22287348
28Proteasome_Homo sapiens_hsa030501.22223752
29Huntingtons disease_Homo sapiens_hsa050161.21992856
30Ovarian steroidogenesis_Homo sapiens_hsa049131.19534512
31Sulfur metabolism_Homo sapiens_hsa009201.15040493
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12836319
33RNA degradation_Homo sapiens_hsa030181.05600009
34Pyruvate metabolism_Homo sapiens_hsa006201.05240495
35RNA polymerase_Homo sapiens_hsa030201.02596172
36Alzheimers disease_Homo sapiens_hsa050101.00903928
37Fanconi anemia pathway_Homo sapiens_hsa034600.91884420
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90051844
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89195729
40Tryptophan metabolism_Homo sapiens_hsa003800.88263799
41Insulin secretion_Homo sapiens_hsa049110.77682171
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71019193
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70315780
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70270235
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.66880619
46PPAR signaling pathway_Homo sapiens_hsa033200.62554602
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61112041
48Collecting duct acid secretion_Homo sapiens_hsa049660.59364504
49Hematopoietic cell lineage_Homo sapiens_hsa046400.58496434
50Butanoate metabolism_Homo sapiens_hsa006500.57304961
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57113512
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.54843942
53Alcoholism_Homo sapiens_hsa050340.53545270
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53124183
55Tuberculosis_Homo sapiens_hsa051520.53110446
56ABC transporters_Homo sapiens_hsa020100.51642163
57Toxoplasmosis_Homo sapiens_hsa051450.51480081
58Basal transcription factors_Homo sapiens_hsa030220.49622015
59Long-term depression_Homo sapiens_hsa047300.48322347
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48071405
61Oxytocin signaling pathway_Homo sapiens_hsa049210.39517018
62Serotonergic synapse_Homo sapiens_hsa047260.39159469
63Purine metabolism_Homo sapiens_hsa002300.38977086
64Olfactory transduction_Homo sapiens_hsa047400.38253414
65Taste transduction_Homo sapiens_hsa047420.38210320
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.33746840
67Propanoate metabolism_Homo sapiens_hsa006400.33489768
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.33248686
69Salivary secretion_Homo sapiens_hsa049700.32873118
70Phagosome_Homo sapiens_hsa041450.32804915
71Circadian entrainment_Homo sapiens_hsa047130.32703016
72Herpes simplex infection_Homo sapiens_hsa051680.31677601
73Fatty acid degradation_Homo sapiens_hsa000710.31545448
74Ribosome_Homo sapiens_hsa030100.31247780
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30063392
76Nucleotide excision repair_Homo sapiens_hsa034200.28559445
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28241131
78Vitamin digestion and absorption_Homo sapiens_hsa049770.27047143
79Glutathione metabolism_Homo sapiens_hsa004800.26661094
80Retinol metabolism_Homo sapiens_hsa008300.26195859
81Gastric acid secretion_Homo sapiens_hsa049710.25687976
82Type II diabetes mellitus_Homo sapiens_hsa049300.25426518
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25279459
84Spliceosome_Homo sapiens_hsa030400.25237370
85Glutamatergic synapse_Homo sapiens_hsa047240.24971321
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23430805
87Peroxisome_Homo sapiens_hsa041460.22400621
88Fat digestion and absorption_Homo sapiens_hsa049750.21934932
89Legionellosis_Homo sapiens_hsa051340.21503120
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20709504
91Sulfur relay system_Homo sapiens_hsa041220.20496136
92Protein export_Homo sapiens_hsa030600.20438360
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20010566
94Glycerolipid metabolism_Homo sapiens_hsa005610.19980165
95Calcium signaling pathway_Homo sapiens_hsa040200.19930247
96Metabolic pathways_Homo sapiens_hsa011000.19721532
97One carbon pool by folate_Homo sapiens_hsa006700.18639474
98Regulation of autophagy_Homo sapiens_hsa041400.17618031
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16721250
100Primary immunodeficiency_Homo sapiens_hsa053400.15412020

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