GNAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.24894726
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.21101000
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83594302
4locomotory exploration behavior (GO:0035641)4.43005734
5activation of protein kinase A activity (GO:0034199)4.30005442
6layer formation in cerebral cortex (GO:0021819)4.26996778
7regulation of synaptic vesicle exocytosis (GO:2000300)4.25807999
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.97928882
9cerebellar granule cell differentiation (GO:0021707)3.91258919
10glutamate secretion (GO:0014047)3.82972807
11synaptic vesicle exocytosis (GO:0016079)3.80952830
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.80499446
13cell communication by electrical coupling (GO:0010644)3.78359452
14proline transport (GO:0015824)3.74814483
15COPI coating of Golgi vesicle (GO:0048205)3.69803397
16Golgi transport vesicle coating (GO:0048200)3.69803397
17regulation of synaptic vesicle transport (GO:1902803)3.69733173
18sodium ion export (GO:0071436)3.69447307
19neuronal ion channel clustering (GO:0045161)3.59205229
20positive regulation of synapse maturation (GO:0090129)3.53576337
21neurotransmitter secretion (GO:0007269)3.52176629
22cell migration in hindbrain (GO:0021535)3.51284076
23cerebellar Purkinje cell layer development (GO:0021680)3.51022396
24glycine transport (GO:0015816)3.40226547
25suckling behavior (GO:0001967)3.37482349
26exploration behavior (GO:0035640)3.37193631
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30912016
28membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.21893552
29cellular potassium ion homeostasis (GO:0030007)3.14968101
30vocalization behavior (GO:0071625)3.13384666
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12657510
32innervation (GO:0060384)3.09854679
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09257076
34regulation of glutamate receptor signaling pathway (GO:1900449)3.05831250
35positive regulation of neurotransmitter transport (GO:0051590)2.99991421
36regulation of ARF protein signal transduction (GO:0032012)2.98521375
37cytoskeletal anchoring at plasma membrane (GO:0007016)2.95446594
38negative regulation of dendrite morphogenesis (GO:0050774)2.92444593
39plasma membrane repair (GO:0001778)2.91987524
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91431443
41membrane repolarization during action potential (GO:0086011)2.89538305
42vesicle transport along microtubule (GO:0047496)2.88769463
43neuromuscular process controlling posture (GO:0050884)2.88356975
44response to dietary excess (GO:0002021)2.86441293
45synaptic vesicle endocytosis (GO:0048488)2.85985661
46regulation of synapse structural plasticity (GO:0051823)2.85740965
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85689456
48* dopamine receptor signaling pathway (GO:0007212)2.85451219
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84308265
50mitochondrion transport along microtubule (GO:0047497)2.84308265
51chemosensory behavior (GO:0007635)2.83780711
52neuron cell-cell adhesion (GO:0007158)2.82885618
53postsynaptic membrane organization (GO:0001941)2.82732743
54positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82107551
55establishment of mitochondrion localization (GO:0051654)2.81814989
56regulation of neuronal synaptic plasticity (GO:0048168)2.80795209
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80105648
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79900362
59dendrite morphogenesis (GO:0048813)2.79499014
60dendritic spine organization (GO:0097061)2.78661257
61growth hormone secretion (GO:0030252)2.76862692
62dendritic spine morphogenesis (GO:0060997)2.76129022
63neuromuscular process controlling balance (GO:0050885)2.75873363
64regulation of synapse maturation (GO:0090128)2.73644277
65neuronal action potential propagation (GO:0019227)2.73311101
66membrane repolarization (GO:0086009)2.71797192
67establishment of nucleus localization (GO:0040023)2.69424533
68detection of calcium ion (GO:0005513)2.68984969
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68966431
70organelle transport along microtubule (GO:0072384)2.68860571
71positive regulation of vesicle fusion (GO:0031340)2.68773650
72positive regulation of potassium ion transmembrane transport (GO:1901381)2.68385776
73regulation of calcium ion-dependent exocytosis (GO:0017158)2.68281613
74neurotransmitter transport (GO:0006836)2.67826238
75negative regulation of microtubule polymerization (GO:0031115)2.67706464
76* adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67075608
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66928302
78cell-cell junction maintenance (GO:0045217)2.66741347
79auditory behavior (GO:0031223)2.65236222
80protein localization to synapse (GO:0035418)2.64657485
81cell communication involved in cardiac conduction (GO:0086065)2.63713664
82potassium ion import (GO:0010107)2.62241300
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.61349206
84regulation of synaptic plasticity (GO:0048167)2.60248223
85mating behavior (GO:0007617)2.60037542
86alanine transport (GO:0032328)2.60008732
87axonal fasciculation (GO:0007413)2.59982481
88apical protein localization (GO:0045176)2.59592882
89axon cargo transport (GO:0008088)2.59290977
90regulation of vesicle fusion (GO:0031338)2.58926004
91neuron recognition (GO:0008038)2.58810028
92embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57479512
93regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56516876
94potassium ion homeostasis (GO:0055075)2.56280887
95regulation of cardioblast proliferation (GO:0003264)2.55486638
96regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55486638
97positive regulation of glycogen biosynthetic process (GO:0045725)2.54420316
98protein targeting to plasma membrane (GO:0072661)2.52149258
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52074900
100axon extension (GO:0048675)2.51533325
101regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.50962545
102regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50695208
103response to pheromone (GO:0019236)2.50591499
104insulin secretion (GO:0030073)2.50554901
105clathrin coat assembly (GO:0048268)2.49194291
106regulation of neurotransmitter levels (GO:0001505)2.48763744
107central nervous system myelination (GO:0022010)2.46720174
108axon ensheathment in central nervous system (GO:0032291)2.46720174
109* cellular response to glucagon stimulus (GO:0071377)2.45711252
110cerebellar Purkinje cell differentiation (GO:0021702)2.45281169
111regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.44681084
112regulation of neurotransmitter secretion (GO:0046928)2.44423928
113positive regulation of nitric-oxide synthase activity (GO:0051000)2.44393837
114signal release (GO:0023061)2.43981244
115positive regulation of neurotransmitter secretion (GO:0001956)2.43784867
116protein retention in ER lumen (GO:0006621)2.42867769
117negative regulation of cell size (GO:0045792)2.42805942
118positive regulation of axon extension (GO:0045773)2.42699721
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.42546090
120cell differentiation in hindbrain (GO:0021533)2.42091539
121coronary vasculature morphogenesis (GO:0060977)2.42045530
122receptor recycling (GO:0001881)2.41678756
123gamma-aminobutyric acid transport (GO:0015812)2.41517879
124negative regulation of glycogen metabolic process (GO:0070874)2.41269088
125camera-type eye morphogenesis (GO:0048593)2.41187131
126negative regulation of catenin import into nucleus (GO:0035414)2.40862245
127vesicle coating (GO:0006901)2.39753962
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.39566195
129cell junction maintenance (GO:0034331)2.38557940
130positive regulation of dendritic spine development (GO:0060999)2.38108944
131positive regulation of dendrite development (GO:1900006)2.36328190
132regulation of clathrin-mediated endocytosis (GO:2000369)2.36094142
133synaptic transmission, glutamatergic (GO:0035249)2.35719497
134skeletal muscle organ development (GO:0060538)2.34733449
135synapse assembly (GO:0007416)2.34596768
136regulation of neurotransmitter transport (GO:0051588)2.34208252
137regulation of glycogen (starch) synthase activity (GO:2000465)2.33512176
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33177790
139cerebellum development (GO:0021549)2.33174232
140cellular sodium ion homeostasis (GO:0006883)2.33020324
141positive regulation of potassium ion transport (GO:0043268)2.32502709
142regulation of amyloid precursor protein catabolic process (GO:1902991)2.32166906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.06441694
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78434306
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62435781
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56008499
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56008499
6* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48801882
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46922942
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44965028
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42176251
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41652080
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39686063
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35483020
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.31898432
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25655141
15DROSHA_22980978_ChIP-Seq_HELA_Human2.23736484
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19810295
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.18244550
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.15268012
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14323701
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13388029
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09697757
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06970020
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.05633290
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03911940
25REST_21632747_ChIP-Seq_MESCs_Mouse1.98399601
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95456488
27* KDM2B_26808549_Chip-Seq_K562_Human1.95046144
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89866353
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89649091
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.88508330
31* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88360890
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81733802
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79077667
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.78300323
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71263955
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69926644
37* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69539571
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66674908
39ZNF274_21170338_ChIP-Seq_K562_Hela1.65028227
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63596314
41* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55772977
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.54523573
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53573163
44LXR_22292898_ChIP-Seq_THP-1_Human1.50781060
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46241070
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.46160645
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44357363
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42482500
49* KDM2B_26808549_Chip-Seq_DND41_Human1.42048539
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41921931
51ZNF263_19887448_ChIP-Seq_K562_Human1.40286795
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40230241
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36317126
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35920675
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34130158
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.32835207
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26301091
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25592155
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23586835
60GBX2_23144817_ChIP-Seq_PC3_Human1.22526599
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.20196165
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.19385412
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18853284
64TCF7_22412390_ChIP-Seq_EML_Mouse1.18691339
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18296245
66CLOCK_20551151_ChIP-Seq_293T_Human1.17472265
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.16299353
68P68_20966046_ChIP-Seq_HELA_Human1.14295964
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.13290894
70* TP53_20018659_ChIP-ChIP_R1E_Mouse1.13158007
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.12689242
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11116095
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10084136
74* AR_19668381_ChIP-Seq_PC3_Human1.10079403
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09733706
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09469126
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07492907
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.06801494
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06662548
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05526055
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05483663
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05420733
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04845453
84* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03992173
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03706943
86AR_21572438_ChIP-Seq_LNCaP_Human1.03697664
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03042357
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03028268
89* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01374226
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01035656
91CTCF_27219007_Chip-Seq_Bcells_Human1.01018419
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.00735038
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97297214
94SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97173927
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96023437
96NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94841476
97* ISL1_27105846_Chip-Seq_CPCs_Mouse0.93653298
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93499266
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92865362
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91727585
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91630850
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91194474
103RACK7_27058665_Chip-Seq_MCF-7_Human0.90850310
104* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90739318
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.90683256
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89538897
107TP53_23651856_ChIP-Seq_MEFs_Mouse0.88840811
108GATA1_19941826_ChIP-Seq_K562_Human0.88769498
109WT1_19549856_ChIP-ChIP_CCG9911_Human0.88598721
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88501594
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88362721
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88039593
113* SMC4_20622854_ChIP-Seq_HELA_Human0.87730083
114* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87491181
115* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86706387
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.86396413
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86373272
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.85282519
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83411238
120SMAD4_21799915_ChIP-Seq_A2780_Human0.82498569
121KLF4_19829295_ChIP-Seq_ESCs_Human0.82150683
122* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81105527
123* ELK3_25401928_ChIP-Seq_HUVEC_Human0.80451148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.36674977
2MP0002909_abnormal_adrenal_gland3.23416096
3* MP0003122_maternal_imprinting2.89542954
4MP0005645_abnormal_hypothalamus_physiol2.86215596
5MP0003635_abnormal_synaptic_transmissio2.85449313
6MP0004270_analgesia2.77066556
7MP0000013_abnormal_adipose_tissue2.76787058
8MP0003283_abnormal_digestive_organ2.72887852
9MP0009780_abnormal_chondrocyte_physiolo2.71346407
10MP0004858_abnormal_nervous_system2.62201374
11* MP0003123_paternal_imprinting2.34746438
12MP0002822_catalepsy2.24409357
13MP0005409_darkened_coat_color2.18800303
14MP0000751_myopathy2.04636942
15MP0002837_dystrophic_cardiac_calcinosis1.98529019
16MP0003880_abnormal_central_pattern1.97856982
17MP0004233_abnormal_muscle_weight1.96822892
18* MP0002063_abnormal_learning/memory/cond1.95252332
19MP0005623_abnormal_meninges_morphology1.94049005
20MP0008961_abnormal_basal_metabolism1.91079752
21MP0002064_seizures1.86290703
22MP0002734_abnormal_mechanical_nocicepti1.83802970
23MP0005646_abnormal_pituitary_gland1.82492743
24* MP0009745_abnormal_behavioral_response1.81861686
25* MP0003787_abnormal_imprinting1.80265251
26MP0009046_muscle_twitch1.75908095
27MP0002638_abnormal_pupillary_reflex1.73725005
28MP0003329_amyloid_beta_deposits1.71625716
29MP0002733_abnormal_thermal_nociception1.71366553
30MP0001968_abnormal_touch/_nociception1.70800757
31MP0005423_abnormal_somatic_nervous1.60599854
32MP0002184_abnormal_innervation1.60505462
33MP0004811_abnormal_neuron_physiology1.54384960
34* MP0002572_abnormal_emotion/affect_behav1.53497974
35MP0000955_abnormal_spinal_cord1.50681463
36MP0010386_abnormal_urinary_bladder1.49002155
37MP0006276_abnormal_autonomic_nervous1.48706836
38MP0001970_abnormal_pain_threshold1.42415340
39MP0002272_abnormal_nervous_system1.41009223
40MP0004145_abnormal_muscle_electrophysio1.40056407
41MP0001440_abnormal_grooming_behavior1.39523994
42MP0001501_abnormal_sleep_pattern1.39187084
43MP0000462_abnormal_digestive_system1.38626868
44MP0005379_endocrine/exocrine_gland_phen1.38108532
45MP0001299_abnormal_eye_distance/1.37385872
46MP0002877_abnormal_melanocyte_morpholog1.33083034
47MP0002735_abnormal_chemical_nociception1.30745086
48MP0008569_lethality_at_weaning1.30015513
49MP0003705_abnormal_hypodermis_morpholog1.25704647
50MP0002234_abnormal_pharynx_morphology1.25663345
51MP0003634_abnormal_glial_cell1.22929099
52MP0000778_abnormal_nervous_system1.21696539
53MP0001348_abnormal_lacrimal_gland1.20847132
54MP0002557_abnormal_social/conspecific_i1.20697378
55MP0000534_abnormal_ureter_morphology1.19697352
56MP0004043_abnormal_pH_regulation1.18921718
57MP0004084_abnormal_cardiac_muscle1.18903736
58MP0002163_abnormal_gland_morphology1.17251280
59MP0003172_abnormal_lysosome_physiology1.17227118
60MP0010234_abnormal_vibrissa_follicle1.16960299
61MP0004272_abnormal_basement_membrane1.14427970
62* MP0000003_abnormal_adipose_tissue1.14412612
63MP0000747_muscle_weakness1.14238390
64MP0001188_hyperpigmentation1.14203478
65MP0001502_abnormal_circadian_rhythm1.12782218
66MP0002249_abnormal_larynx_morphology1.12169675
67MP0005187_abnormal_penis_morphology1.11673704
68MP0005167_abnormal_blood-brain_barrier1.11361906
69MP0004885_abnormal_endolymph1.10015220
70MP0002896_abnormal_bone_mineralization1.07440514
71MP0000566_synostosis1.05591457
72MP0001270_distended_abdomen1.05549940
73* MP0002067_abnormal_sensory_capabilities1.05404960
74MP0002751_abnormal_autonomic_nervous1.05316313
75MP0003045_fibrosis1.04940745
76MP0002736_abnormal_nociception_after1.04456197
77MP0003633_abnormal_nervous_system1.03933773
78* MP0001944_abnormal_pancreas_morphology1.03895263
79MP0002882_abnormal_neuron_morphology1.03412433
80MP0004085_abnormal_heartbeat1.00569743
81MP0004924_abnormal_behavior1.00202350
82MP0005386_behavior/neurological_phenoty1.00202350
83* MP0002066_abnormal_motor_capabilities/c0.97869410
84MP0003861_abnormal_nervous_system0.94353732
85MP0006138_congestive_heart_failure0.94176322
86MP0000537_abnormal_urethra_morphology0.93572482
87MP0004036_abnormal_muscle_relaxation0.93244961
88MP0001486_abnormal_startle_reflex0.92499507
89MP0003879_abnormal_hair_cell0.89971571
90MP0000631_abnormal_neuroendocrine_gland0.89253374
91MP0008438_abnormal_cutaneous_collagen0.88930443
92MP0003183_abnormal_peptide_metabolism0.88659185
93* MP0002152_abnormal_brain_morphology0.88328153
94MP0002089_abnormal_postnatal_growth/wei0.87880200
95MP0001905_abnormal_dopamine_level0.87307653
96* MP0002078_abnormal_glucose_homeostasis0.86946655
97MP0002653_abnormal_ependyma_morphology0.86896743
98MP0000759_abnormal_skeletal_muscle0.85620175
99MP0002229_neurodegeneration0.84500914
100MP0004215_abnormal_myocardial_fiber0.82393447
101MP0004510_myositis0.82196181
102MP0002693_abnormal_pancreas_physiology0.81180859
103* MP0003942_abnormal_urinary_system0.81108017
104MP0005076_abnormal_cell_differentiation0.81035585
105* MP0002069_abnormal_eating/drinking_beha0.80901215
106MP0001984_abnormal_olfaction0.80790526
107MP0000639_abnormal_adrenal_gland0.80436657
108MP0000678_abnormal_parathyroid_gland0.79829346
109MP0002269_muscular_atrophy0.78998807
110MP0004087_abnormal_muscle_fiber0.78658560
111MP0000920_abnormal_myelination0.77443108
112MP0005503_abnormal_tendon_morphology0.76235857
113* MP0003953_abnormal_hormone_level0.76066752
114MP0003385_abnormal_body_wall0.75746938
115MP0003631_nervous_system_phenotype0.74388632
116MP0002972_abnormal_cardiac_muscle0.73397933
117* MP0004130_abnormal_muscle_cell0.73169537
118MP0002106_abnormal_muscle_physiology0.72684674
119* MP0003121_genomic_imprinting0.72490989
120MP0006054_spinal_hemorrhage0.72282154
121* MP0003959_abnormal_lean_body0.72098133
122MP0002752_abnormal_somatic_nervous0.70319563
123MP0003690_abnormal_glial_cell0.69423013
124* MP0001943_abnormal_respiration0.68908699
125MP0005257_abnormal_intraocular_pressure0.68823632
126MP0000579_abnormal_nail_morphology0.67002293
127MP0002876_abnormal_thyroid_physiology0.66176989
128* MP0010769_abnormal_survival0.65990541
129MP0003632_abnormal_nervous_system0.65981770
130* MP0010770_preweaning_lethality0.65380254
131* MP0002082_postnatal_lethality0.65380254
132* MP0001731_abnormal_postnatal_growth0.64595888
133* MP0002081_perinatal_lethality0.64133804
134MP0005058_abnormal_lysosome_morphology0.63542486
135MP0005535_abnormal_body_temperature0.62925220
136MP0005220_abnormal_exocrine_pancreas0.62512031
137MP0003938_abnormal_ear_development0.61141659
138* MP0010768_mortality/aging0.60639415

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)3.85288576
2Hypoventilation (HP:0002791)3.60816596
3Pheochromocytoma (HP:0002666)3.55940890
4Obstructive sleep apnea (HP:0002870)3.39523505
5Myokymia (HP:0002411)3.28803819
6Supranuclear gaze palsy (HP:0000605)3.19681508
7Papilledema (HP:0001085)3.10896050
8Hypoglycemic seizures (HP:0002173)3.01616622
9Neuroendocrine neoplasm (HP:0100634)2.99179102
10* Hypercortisolism (HP:0001578)2.99087197
11Insomnia (HP:0100785)2.98523152
12Focal seizures (HP:0007359)2.95833671
13Cerebral aneurysm (HP:0004944)2.92682000
14Hyperacusis (HP:0010780)2.90027171
15Akinesia (HP:0002304)2.89907418
16* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89420292
17Focal motor seizures (HP:0011153)2.80959465
18Ankle clonus (HP:0011448)2.70140298
19Action tremor (HP:0002345)2.67306689
20Asymmetry of the thorax (HP:0001555)2.66562178
21Renal duplication (HP:0000075)2.57280357
22Failure to thrive in infancy (HP:0001531)2.49320421
23Neoplasm of the heart (HP:0100544)2.48249382
24Fetal akinesia sequence (HP:0001989)2.47438881
25Ventricular fibrillation (HP:0001663)2.44834897
26* Depression (HP:0000716)2.43185919
27Sleep apnea (HP:0010535)2.40269585
28Neoplasm of the peripheral nervous system (HP:0100007)2.35311940
29Germ cell neoplasia (HP:0100728)2.34145845
30Deep palmar crease (HP:0006191)2.31785115
31Bowel diverticulosis (HP:0005222)2.31243348
32Cerebral inclusion bodies (HP:0100314)2.29388383
33Elfin facies (HP:0004428)2.27211341
34Buphthalmos (HP:0000557)2.26576581
35Abnormal pancreas size (HP:0012094)2.25791315
36Amblyopia (HP:0000646)2.25704791
37J-shaped sella turcica (HP:0002680)2.24031028
38Atonic seizures (HP:0010819)2.21520691
39Generalized tonic-clonic seizures (HP:0002069)2.20933923
40Long toe (HP:0010511)2.19984661
41Bladder diverticulum (HP:0000015)2.18258957
42Truncus arteriosus (HP:0001660)2.16917404
43Spastic gait (HP:0002064)2.16824455
44Hypoglycemic coma (HP:0001325)2.14441986
45Shallow orbits (HP:0000586)2.14302876
46Broad metatarsal (HP:0001783)2.12296643
47Protrusio acetabuli (HP:0003179)2.12258476
48Absence seizures (HP:0002121)2.09430860
49Febrile seizures (HP:0002373)2.08219683
50Abnormality of the corticospinal tract (HP:0002492)2.07994114
51Hand muscle atrophy (HP:0009130)2.07717294
52Pointed chin (HP:0000307)2.07016474
53Upper limb amyotrophy (HP:0009129)2.06638102
54Distal upper limb amyotrophy (HP:0007149)2.06638102
55Megalencephaly (HP:0001355)2.06592305
56Epileptic encephalopathy (HP:0200134)2.05310747
57Focal dystonia (HP:0004373)2.04997651
58Double outlet right ventricle (HP:0001719)2.04862987
59Congenital malformation of the right heart (HP:0011723)2.04862987
60* Agitation (HP:0000713)2.04808205
61Overriding aorta (HP:0002623)2.03116416
62Congenital glaucoma (HP:0001087)2.02217728
63Diplopia (HP:0000651)2.01999372
64Abnormality of binocular vision (HP:0011514)2.01999372
65Hypercalciuria (HP:0002150)2.01561832
66Intention tremor (HP:0002080)2.01534016
67Insidious onset (HP:0003587)2.00454439
68Termporal pattern (HP:0011008)2.00454439
69Increased variability in muscle fiber diameter (HP:0003557)1.99808907
70Polyphagia (HP:0002591)1.99544477
71Postural tremor (HP:0002174)1.98962604
72Annular pancreas (HP:0001734)1.98144656
73Poor eye contact (HP:0000817)1.97363248
74Rapidly progressive (HP:0003678)1.96331750
75Ankyloglossia (HP:0010296)1.96176050
76Impaired social interactions (HP:0000735)1.95329286
77Abnormal social behavior (HP:0012433)1.95329286
78Insulin-resistant diabetes mellitus (HP:0000831)1.94304962
79Bundle branch block (HP:0011710)1.93008885
80Craniofacial dystonia (HP:0012179)1.92861082
81Genetic anticipation (HP:0003743)1.92845104
82Neurofibrillary tangles (HP:0002185)1.92586966
83Hyperglycemia (HP:0003074)1.91571028
84Hepatoblastoma (HP:0002884)1.90417659
85Renovascular hypertension (HP:0100817)1.90404495
86Torticollis (HP:0000473)1.88402501
87Postural instability (HP:0002172)1.88293787
88Turricephaly (HP:0000262)1.88102131
89Hypsarrhythmia (HP:0002521)1.88021783
90Abnormality of the lower motor neuron (HP:0002366)1.87826787
91* Abnormality of calcium-phosphate metabolism (HP:0100530)1.86932539
92Urinary urgency (HP:0000012)1.86613522
93EEG with generalized epileptiform discharges (HP:0011198)1.86039972
94Progressive cerebellar ataxia (HP:0002073)1.85053757
95Hemiplegia (HP:0002301)1.84662539
96Nuclear cataract (HP:0100018)1.84341510
97Abnormal eating behavior (HP:0100738)1.84104281
98Ketoacidosis (HP:0001993)1.83531132
99* Hyperthyroidism (HP:0000836)1.83517473
100* Anxiety (HP:0000739)1.83344114
101Dysmetria (HP:0001310)1.83158396
102Truncal ataxia (HP:0002078)1.82498110
103Late onset (HP:0003584)1.82474353
104Spinal canal stenosis (HP:0003416)1.80732985
105Adducted thumb (HP:0001181)1.80703242
106Bronchomalacia (HP:0002780)1.78817250
107Diminished movement (HP:0002374)1.78729899
108Hyperinsulinemic hypoglycemia (HP:0000825)1.77020019
109Epileptiform EEG discharges (HP:0011182)1.77011895
110Patellar dislocation (HP:0002999)1.76535147
111Neuronal loss in central nervous system (HP:0002529)1.76316184
112Impaired vibration sensation in the lower limbs (HP:0002166)1.76183763
113Long palpebral fissure (HP:0000637)1.75463901
114Exotropia (HP:0000577)1.75031982
115Mildly elevated creatine phosphokinase (HP:0008180)1.74810855
116Abnormality of the aortic arch (HP:0012303)1.74232339
117Hypercalcemia (HP:0003072)1.73647850
118Limb dystonia (HP:0002451)1.73574376
119Vertebral arch anomaly (HP:0008438)1.73108960
120Overgrowth (HP:0001548)1.72922275
121Hemiparesis (HP:0001269)1.72725126
122Heterochromia iridis (HP:0001100)1.72555228
123Sudden death (HP:0001699)1.72202232
124Apathy (HP:0000741)1.71984507
125Lower limb asymmetry (HP:0100559)1.71173891
126Myotonia (HP:0002486)1.70438235
127Heterotopia (HP:0002282)1.70378118
128Increased circulating renin level (HP:0000848)1.69430527
129Deviation of the hallux (HP:0010051)1.69381262
130Shoulder girdle muscle weakness (HP:0003547)1.69310132
131Mutism (HP:0002300)1.68274002
132Urinary bladder sphincter dysfunction (HP:0002839)1.67964893
133* Precocious puberty (HP:0000826)1.67836378
134Symptomatic seizures (HP:0011145)1.67741220
135Flat cornea (HP:0007720)1.67476714
136Lymphangioma (HP:0100764)1.67443789
137Exercise-induced myalgia (HP:0003738)1.66922622
138* Hyperparathyroidism (HP:0000843)1.66488797
139* Adrenal overactivity (HP:0002717)1.66463316
140Hallux valgus (HP:0001822)1.65285997
141Lower limb amyotrophy (HP:0007210)1.65186427
142Limb-girdle muscle atrophy (HP:0003797)1.65112873
143Poor suck (HP:0002033)1.64609602
144Tetraplegia (HP:0002445)1.64562843
145Thin bony cortex (HP:0002753)1.63751374
146Abnormality of pain sensation (HP:0010832)1.62911937
147Impaired pain sensation (HP:0007328)1.62911937
148* Macroorchidism (HP:0000053)1.62848358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.62352933
2MAP3K93.38916106
3NTRK33.33272202
4NTRK12.79220828
5PRKD32.49426591
6MARK12.37426918
7KSR22.33660922
8PAK62.32055111
9PKN22.31815568
10MINK12.21959568
11MAP3K42.15743476
12PDGFRA2.05732715
13SCYL21.89397887
14CASK1.88504470
15UHMK11.81393055
16CAMKK11.79960611
17LATS21.77860757
18RET1.71641007
19RIPK11.64836660
20MAP3K21.60967297
21DAPK21.53465719
22MAP2K41.51292742
23PAK31.50572423
24PHKG11.47257378
25PHKG21.47257378
26NTRK21.42845180
27LMTK21.38828685
28WNK31.36755920
29FGFR21.35789796
30FGFR41.35306840
31PTK21.33952014
32PRKCH1.24539508
33DDR21.23567477
34ALK1.22918268
35KSR11.22554279
36FER1.19258113
37CDK121.14393572
38TYRO31.14056979
39SMG11.13226960
40CDK51.12833972
41PTK61.12810112
42MAP3K121.12495082
43MAPK151.07961760
44MAP3K11.06095962
45WNK41.04108542
46TAOK11.02403033
47STK381.02099141
48PRPF4B1.01695475
49CAMK1G1.00706308
50MAP2K70.99953065
51ERN10.96383136
52EPHA20.95700750
53HIPK20.92019876
54EEF2K0.91099831
55LIMK10.90145246
56SGK20.89509555
57CDC42BPA0.87890631
58CAMKK20.87734734
59DMPK0.87610856
60NEK10.87393613
61SIK10.86923651
62CDK140.84079085
63CSNK1G20.82669660
64MAP2K20.82307801
65BRAF0.82199579
66SIK20.76450697
67CDK150.75817285
68TTN0.75054474
69FGFR30.73294874
70WNK10.72826740
71CDK180.72663634
72EPHA40.72312968
73GRK50.71039184
74CAMK10.70897248
75PLK20.70814242
76PRKD20.69664709
77PDGFRB0.69280351
78PRKCG0.68971068
79CAMK2B0.68911425
80CAMK2D0.68875477
81MAP3K100.68864039
82MAP2K10.68810391
83CDK11A0.65261005
84RPS6KA20.64749147
85DYRK1A0.63213378
86NEK60.62882190
87EPHB10.61856370
88PDPK10.61137026
89MAPK120.59639602
90ICK0.58232490
91MARK20.58161814
92DYRK1B0.57780729
93CAMK2G0.57019418
94PAK20.56795739
95BMX0.56232932
96PRKCZ0.56015856
97DYRK20.55383550
98ROCK20.54880049
99STK110.54804315
100ILK0.54451256
101MAPK100.54186971
102DAPK10.53818356
103PRKD10.53032410
104ROCK10.51453156
105CDK190.51093768
106TESK10.50958703
107PRKAA10.50920298
108EPHB20.50572748
109SGK10.50403589
110RPS6KB20.50013498
111FGFR10.49049783
112LRRK20.48904343
113IRAK20.48821188
114MAP3K70.47770665
115CAMK2A0.47761751
116PIK3CA0.46886406
117MTOR0.46868222
118MAPK130.46849916
119BRSK10.45936219
120CSNK1E0.45451469
121ARAF0.44439069
122PNCK0.43669209
123PTK2B0.43482605
124PASK0.42329006
125PDK10.41894443
126CSNK1G30.41000054
127CAMK1D0.40790500
128SGK30.39963880
129SGK2230.39944358
130SGK4940.39944358
131RPS6KA30.38428320

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.64710515
2* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44186283
3* Insulin secretion_Homo sapiens_hsa049112.16247810
4* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10528022
5GABAergic synapse_Homo sapiens_hsa047272.00250291
6* Circadian entrainment_Homo sapiens_hsa047131.92637977
7Long-term potentiation_Homo sapiens_hsa047201.87587432
8* Dopaminergic synapse_Homo sapiens_hsa047281.75781297
9* Amphetamine addiction_Homo sapiens_hsa050311.69344094
10Nicotine addiction_Homo sapiens_hsa050331.67612676
11* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66029674
12* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65753852
13Type II diabetes mellitus_Homo sapiens_hsa049301.64952233
14Cholinergic synapse_Homo sapiens_hsa047251.60570970
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59312273
16Olfactory transduction_Homo sapiens_hsa047401.58329666
17* Gastric acid secretion_Homo sapiens_hsa049711.54369681
18* Cocaine addiction_Homo sapiens_hsa050301.48425822
19* Salivary secretion_Homo sapiens_hsa049701.43651880
20* Morphine addiction_Homo sapiens_hsa050321.41369988
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40937906
22* Estrogen signaling pathway_Homo sapiens_hsa049151.40904534
23* Glutamatergic synapse_Homo sapiens_hsa047241.40293529
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36014979
25Glioma_Homo sapiens_hsa052141.33641127
26* Renin secretion_Homo sapiens_hsa049241.32352712
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30486846
28* Oxytocin signaling pathway_Homo sapiens_hsa049211.26916469
29* GnRH signaling pathway_Homo sapiens_hsa049121.23645381
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23232616
31* Gap junction_Homo sapiens_hsa045401.23158690
32* Vibrio cholerae infection_Homo sapiens_hsa051101.15431261
33* Long-term depression_Homo sapiens_hsa047301.13721641
34Taste transduction_Homo sapiens_hsa047421.13396224
35* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13058014
36Notch signaling pathway_Homo sapiens_hsa043301.11579552
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.10514229
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10487114
39Nitrogen metabolism_Homo sapiens_hsa009101.10014734
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.09033273
41Vitamin B6 metabolism_Homo sapiens_hsa007501.08845710
42* Dilated cardiomyopathy_Homo sapiens_hsa054141.07246853
43* Melanogenesis_Homo sapiens_hsa049161.04568302
44* cAMP signaling pathway_Homo sapiens_hsa040241.04389614
45Insulin signaling pathway_Homo sapiens_hsa049101.03702685
46Dorso-ventral axis formation_Homo sapiens_hsa043201.01903333
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00972571
48mTOR signaling pathway_Homo sapiens_hsa041500.97974561
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97355730
50Axon guidance_Homo sapiens_hsa043600.97003334
51Inositol phosphate metabolism_Homo sapiens_hsa005620.95711997
52* Thyroid hormone synthesis_Homo sapiens_hsa049180.94614363
53Cardiac muscle contraction_Homo sapiens_hsa042600.94144173
54* Serotonergic synapse_Homo sapiens_hsa047260.93859731
55* Glucagon signaling pathway_Homo sapiens_hsa049220.91338188
56ErbB signaling pathway_Homo sapiens_hsa040120.90613001
57* Pancreatic secretion_Homo sapiens_hsa049720.89747088
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89386292
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88881227
60Endometrial cancer_Homo sapiens_hsa052130.88256061
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87611185
62Renal cell carcinoma_Homo sapiens_hsa052110.86036770
63* Phospholipase D signaling pathway_Homo sapiens_hsa040720.85983077
64* Calcium signaling pathway_Homo sapiens_hsa040200.84789134
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.84725829
66Collecting duct acid secretion_Homo sapiens_hsa049660.83244035
67* Vascular smooth muscle contraction_Homo sapiens_hsa042700.83243996
68VEGF signaling pathway_Homo sapiens_hsa043700.81855797
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80826868
70* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79361829
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79345266
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79202649
73Prion diseases_Homo sapiens_hsa050200.78227611
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78174041
75Oocyte meiosis_Homo sapiens_hsa041140.78160530
76Focal adhesion_Homo sapiens_hsa045100.78155552
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77641404
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73923263
79Endocytosis_Homo sapiens_hsa041440.72990757
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71745141
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71346633
82Type I diabetes mellitus_Homo sapiens_hsa049400.71038297
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70152705
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70008974
85Non-small cell lung cancer_Homo sapiens_hsa052230.69437160
86Choline metabolism in cancer_Homo sapiens_hsa052310.69252324
87Chronic myeloid leukemia_Homo sapiens_hsa052200.66641260
88AMPK signaling pathway_Homo sapiens_hsa041520.66540549
89Insulin resistance_Homo sapiens_hsa049310.65829110
90Prolactin signaling pathway_Homo sapiens_hsa049170.64952341
91Proteoglycans in cancer_Homo sapiens_hsa052050.64475266
92Protein digestion and absorption_Homo sapiens_hsa049740.63100809
93Bladder cancer_Homo sapiens_hsa052190.61666889
94MAPK signaling pathway_Homo sapiens_hsa040100.61428286
95Colorectal cancer_Homo sapiens_hsa052100.61007498
96Thyroid cancer_Homo sapiens_hsa052160.60950730
97Adherens junction_Homo sapiens_hsa045200.60395143
98Hedgehog signaling pathway_Homo sapiens_hsa043400.59648569
99Wnt signaling pathway_Homo sapiens_hsa043100.59170654
100Circadian rhythm_Homo sapiens_hsa047100.58734510
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58149229
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57763375
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57334768
104* Rap1 signaling pathway_Homo sapiens_hsa040150.53662758
105Hippo signaling pathway_Homo sapiens_hsa043900.52271171
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.50390883
107* Bile secretion_Homo sapiens_hsa049760.49678018
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.49475635
109N-Glycan biosynthesis_Homo sapiens_hsa005100.49349708
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.48913108
111Ras signaling pathway_Homo sapiens_hsa040140.47633069
112Tight junction_Homo sapiens_hsa045300.47413219
113Melanoma_Homo sapiens_hsa052180.46173370
114Pancreatic cancer_Homo sapiens_hsa052120.45831556

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