GNAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* visual perception (GO:0007601)8.55144010
2* sensory perception of light stimulus (GO:0050953)8.45824293
3regulation of DNA methylation (GO:0044030)8.11567712
4* detection of light stimulus involved in sensory perception (GO:0050962)8.11459731
5* detection of light stimulus involved in visual perception (GO:0050908)8.11459731
6DNA methylation involved in gamete generation (GO:0043046)7.97937746
7regulation of female gonad development (GO:2000194)7.97649819
8synapsis (GO:0007129)7.65901145
9GMP metabolic process (GO:0046037)7.65550559
10positive regulation of cGMP biosynthetic process (GO:0030828)7.50070740
11regulation of cGMP metabolic process (GO:0030823)7.38625659
12retinal rod cell development (GO:0046548)7.36825483
13regulation of meiosis I (GO:0060631)7.28918157
14meiotic cell cycle (GO:0051321)7.25770047
15cellular response to light stimulus (GO:0071482)7.14129442
16* detection of external stimulus (GO:0009581)7.08118831
17regulation of cGMP biosynthetic process (GO:0030826)7.04678431
18* detection of abiotic stimulus (GO:0009582)6.93168690
19positive regulation of cGMP metabolic process (GO:0030825)6.63008575
20regulation of acrosome reaction (GO:0060046)6.30605616
21male meiosis I (GO:0007141)6.17247537
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.89412138
23multicellular organism reproduction (GO:0032504)5.89075163
24chromosome organization involved in meiosis (GO:0070192)5.82159543
25retina development in camera-type eye (GO:0060041)5.75497813
26protein localization to kinetochore (GO:0034501)5.71706194
27regulation of histone H3-K9 methylation (GO:0051570)5.66770058
28photoreceptor cell differentiation (GO:0046530)5.59295155
29eye photoreceptor cell differentiation (GO:0001754)5.59295155
30female gamete generation (GO:0007292)5.59209448
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.45921174
32male meiosis (GO:0007140)5.43783886
33positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)5.38227214
34protein localization to chromosome (GO:0034502)5.37291070
35positive regulation of histone H3-K4 methylation (GO:0051571)5.32769116
36positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)5.31682831
37synaptonemal complex assembly (GO:0007130)5.21389936
38gene silencing by RNA (GO:0031047)5.16611214
39meiosis I (GO:0007127)5.13057141
40protein localization to chromosome, centromeric region (GO:0071459)4.99612404
41negative regulation of histone methylation (GO:0031061)4.98959508
42positive regulation of ERBB signaling pathway (GO:1901186)4.98697288
43regulation of double-strand break repair via homologous recombination (GO:0010569)4.85189384
44meiotic nuclear division (GO:0007126)4.73323656
45relaxation of smooth muscle (GO:0044557)4.70898544
46synaptonemal complex organization (GO:0070193)4.65766020
47adaptation of signaling pathway (GO:0023058)4.63313600
48oocyte development (GO:0048599)4.63190600
49cellular response to radiation (GO:0071478)4.59967605
50negative regulation of reproductive process (GO:2000242)4.56795528
51mitotic chromosome condensation (GO:0007076)4.53064970
52regulation of steroid hormone secretion (GO:2000831)4.44522159
53nonmotile primary cilium assembly (GO:0035058)4.44488463
54regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.42326505
55receptor guanylyl cyclase signaling pathway (GO:0007168)4.26228996
56mitotic metaphase plate congression (GO:0007080)4.22600428
57attachment of spindle microtubules to kinetochore (GO:0008608)4.21478458
58negative regulation of organelle assembly (GO:1902116)4.16695382
59glycine transport (GO:0015816)4.16367968
60regulation of cell maturation (GO:1903429)4.15503387
61meiotic cell cycle process (GO:1903046)4.14056863
62estrogen biosynthetic process (GO:0006703)4.13887755
63chemosensory behavior (GO:0007635)4.10316633
64short-term memory (GO:0007614)4.08864756
65positive regulation of mitotic sister chromatid separation (GO:1901970)4.07861494
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.07861494
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.07861494
68DNA alkylation (GO:0006305)4.06261870
69DNA methylation (GO:0006306)4.06261870
70* sensory perception (GO:0007600)4.01391847
71protein kinase C signaling (GO:0070528)3.90776312
72behavioral response to ethanol (GO:0048149)3.90453475
73regulation of penile erection (GO:0060405)3.89539672
74centriole replication (GO:0007099)3.88758356
75* response to light stimulus (GO:0009416)3.88365780
76DNA synthesis involved in DNA repair (GO:0000731)3.87728404
77phosphorelay signal transduction system (GO:0000160)3.85540572
78binding of sperm to zona pellucida (GO:0007339)3.83122443
79regulation of meiosis (GO:0040020)3.82440528
80reproduction (GO:0000003)3.80416982
81positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.78876672
82fertilization (GO:0009566)3.78502862
83positive regulation of histone methylation (GO:0031062)3.77606118
84regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.74348097
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.74348097
86regulation of voltage-gated calcium channel activity (GO:1901385)3.69686201
87response to histamine (GO:0034776)3.67929744
88positive regulation of gastrulation (GO:2000543)3.67839213
89establishment of chromosome localization (GO:0051303)3.65960486
90retinoid metabolic process (GO:0001523)3.62701982
91regulation of meiotic cell cycle (GO:0051445)3.55629037
92positive regulation of chromosome segregation (GO:0051984)3.51830822
93CDP-diacylglycerol biosynthetic process (GO:0016024)3.51679760
94positive regulation of meiosis (GO:0045836)3.51353124
95primitive streak formation (GO:0090009)3.50903973
96citrulline biosynthetic process (GO:0019240)3.50191041
97CENP-A containing nucleosome assembly (GO:0034080)3.47962989
98diterpenoid metabolic process (GO:0016101)3.39466182
99chromatin remodeling at centromere (GO:0031055)3.39248854
100metaphase plate congression (GO:0051310)3.38626310
101cell morphogenesis involved in neuron differentiation (GO:0048667)3.36085230
102positive regulation of sodium ion transmembrane transport (GO:1902307)3.33587873
103negative regulation of transcription regulatory region DNA binding (GO:2000678)3.32664548
104positive regulation of cyclase activity (GO:0031281)3.28432629
105positive regulation of humoral immune response (GO:0002922)3.26632076
106regulation of clathrin-mediated endocytosis (GO:2000369)3.24322980
107positive regulation of meiotic cell cycle (GO:0051446)3.24247510
108regulation of spindle organization (GO:0090224)3.21631708
109CDP-diacylglycerol metabolic process (GO:0046341)3.19297661
110retina layer formation (GO:0010842)3.18955249
111positive regulation of neurotransmitter transport (GO:0051590)3.18491380
112sperm-egg recognition (GO:0035036)3.18269081
113DNA methylation or demethylation (GO:0044728)3.14397653
114reciprocal DNA recombination (GO:0035825)3.12921027
115reciprocal meiotic recombination (GO:0007131)3.12921027
116terpenoid metabolic process (GO:0006721)3.12702080
117* neuron development (GO:0048666)3.12551042
118membrane hyperpolarization (GO:0060081)3.12021505
119oogenesis (GO:0048477)3.08931175
120negative regulation of DNA-dependent DNA replication (GO:2000104)3.07262058
121sister chromatid cohesion (GO:0007062)3.06959661
122regulation of steroid hormone biosynthetic process (GO:0090030)3.05914977
123gene silencing (GO:0016458)3.04072558
124base-excision repair, AP site formation (GO:0006285)3.03046837
125DNA modification (GO:0006304)3.01876792
126single fertilization (GO:0007338)3.01296614
127positive regulation of lyase activity (GO:0051349)3.01096806
128positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00338679
129regulation of spindle checkpoint (GO:0090231)3.00090905
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98975646
131righting reflex (GO:0060013)2.98645921
132DNA replication checkpoint (GO:0000076)2.98022798
133histone exchange (GO:0043486)2.97413142
134microtubule severing (GO:0051013)2.97162995
135regulation of double-strand break repair (GO:2000779)2.96730624
136histone H3-K9 demethylation (GO:0033169)2.95041350
137prenylation (GO:0097354)2.92983164
138protein prenylation (GO:0018342)2.92983164
139phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.87629782
140DNA replication-dependent nucleosome assembly (GO:0006335)2.86918970
141DNA replication-dependent nucleosome organization (GO:0034723)2.86918970
142behavioral response to cocaine (GO:0048148)2.86650843
143regulation of histone methylation (GO:0031060)2.84004348
144somite rostral/caudal axis specification (GO:0032525)2.82921152
145regulation of histone H3-K4 methylation (GO:0051569)2.82376891
146fatty acid elongation (GO:0030497)2.81045030
147startle response (GO:0001964)2.80775295
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79502019
149positive regulation of reproductive process (GO:2000243)2.78001970
150negative regulation of histone modification (GO:0031057)2.77017196
151regulation of mitotic spindle checkpoint (GO:1903504)2.76560773
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76560773
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76456906
154negative regulation of hormone biosynthetic process (GO:0032353)2.76141577
155oocyte maturation (GO:0001556)2.75788316
156synaptic transmission, dopaminergic (GO:0001963)2.74478212
157neuron fate determination (GO:0048664)2.69869518
158regulation of catecholamine metabolic process (GO:0042069)2.65825949
159regulation of dopamine metabolic process (GO:0042053)2.65825949
160germ cell development (GO:0007281)2.65281830
161arachidonic acid secretion (GO:0050482)2.65247740
162icosanoid secretion (GO:0032309)2.65247740
163histone H2A acetylation (GO:0043968)2.64900157
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64030442
165* response to radiation (GO:0009314)2.63640069
166lipid translocation (GO:0034204)2.58228090
167phospholipid translocation (GO:0045332)2.58228090
168dopamine receptor signaling pathway (GO:0007212)2.57403416
169regulation of neurotransmitter uptake (GO:0051580)2.55859271
170regulation of ARF protein signal transduction (GO:0032012)2.55693791
171regulation of cyclase activity (GO:0031279)2.52905700
172negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.51755876
173negative regulation of calcium ion transmembrane transport (GO:1903170)2.51755876
174isoprenoid metabolic process (GO:0006720)2.51110513
175negative regulation of cation channel activity (GO:2001258)2.47538538
176import into cell (GO:0098657)2.45566869
177auditory receptor cell stereocilium organization (GO:0060088)2.45422548
178peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43700602
179synaptic vesicle maturation (GO:0016188)2.43322307
180retina homeostasis (GO:0001895)2.38044911
181cellular response to abiotic stimulus (GO:0071214)2.35025877
182mitochondrion transport along microtubule (GO:0047497)2.34917523
183establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34917523
184regulation of lyase activity (GO:0051339)2.34876116
185regulation of rhodopsin mediated signaling pathway (GO:0022400)17.9346541
186rhodopsin mediated signaling pathway (GO:0016056)17.2652927
187* retinal cone cell development (GO:0046549)16.6315519
188protein-chromophore linkage (GO:0018298)14.5632016
189positive regulation of guanylate cyclase activity (GO:0031284)12.9822248
190regulation of guanylate cyclase activity (GO:0031282)11.7411218
191phototransduction, visible light (GO:0007603)11.3500527
192* photoreceptor cell development (GO:0042461)11.0677302
193* eye photoreceptor cell development (GO:0042462)10.9177674
194* phototransduction (GO:0007602)10.8725432
195* detection of visible light (GO:0009584)10.4014167
196photoreceptor cell maintenance (GO:0045494)10.2993588
197* detection of light stimulus (GO:0009583)10.1587067
198piRNA metabolic process (GO:0034587)10.0349687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.27162444
2VDR_22108803_ChIP-Seq_LS180_Human5.00134766
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.52681979
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48096030
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37981040
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.46016279
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.29886848
8GBX2_23144817_ChIP-Seq_PC3_Human2.97850205
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.82785435
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78644616
11E2F7_22180533_ChIP-Seq_HELA_Human2.73808915
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.55148184
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54750381
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49290072
15DROSHA_22980978_ChIP-Seq_HELA_Human2.22722158
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18817116
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09855421
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09855421
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09855421
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09744211
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.08493778
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.06451479
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02591909
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.00275370
25EZH2_22144423_ChIP-Seq_EOC_Human11.8480057
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98345258
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94805295
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.82908335
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82207992
30BCAT_22108803_ChIP-Seq_LS180_Human1.80272918
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.79181761
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77442356
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76660480
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74500735
35AR_21572438_ChIP-Seq_LNCaP_Human1.72204556
36REST_21632747_ChIP-Seq_MESCs_Mouse1.71558558
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71452639
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69719983
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68056089
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66585490
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63210543
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62414741
43KDM2B_26808549_Chip-Seq_K562_Human1.61416984
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60735950
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59469799
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59083401
47AR_19668381_ChIP-Seq_PC3_Human1.55450295
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54236685
49CBP_20019798_ChIP-Seq_JUKART_Human1.54236685
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54042278
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52692094
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52544412
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.51964727
54TP53_22573176_ChIP-Seq_HFKS_Human1.50590825
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50495197
56IRF1_19129219_ChIP-ChIP_H3396_Human1.50048228
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48132587
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45308252
59IGF1R_20145208_ChIP-Seq_DFB_Human1.44837713
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.44437491
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.43828786
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.43531798
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42528773
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.39269119
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.39139686
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38722994
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38341400
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.37093996
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36752307
70HTT_18923047_ChIP-ChIP_STHdh_Human1.35790050
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35372881
72ZNF274_21170338_ChIP-Seq_K562_Hela1.33932000
73EWS_26573619_Chip-Seq_HEK293_Human1.32322180
74TBL1_22424771_ChIP-Seq_293T_Human1.31164471
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.30472928
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30281665
77SMAD4_21799915_ChIP-Seq_A2780_Human1.28373638
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27922764
79CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27905673
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.27607122
81RNF2_27304074_Chip-Seq_NSC_Mouse1.27314592
82CREB1_26743006_Chip-Seq_LNCaP_Human1.26361055
83CBP_21632823_ChIP-Seq_H3396_Human1.26350980
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25523870
85STAT3_23295773_ChIP-Seq_U87_Human1.23053258
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22750511
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22635971
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.22559295
89AR_25329375_ChIP-Seq_VCAP_Human1.21782089
90MYC_18940864_ChIP-ChIP_HL60_Human1.20705265
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19890464
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.19831563
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.19600257
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18418849
95FOXP3_21729870_ChIP-Seq_TREG_Human1.17550574
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16461904
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15157055
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14049964
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14030685
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.12396934
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10558551
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09804268
103WDR5_24793694_ChIP-Seq_LNCAP_Human1.09456437
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08391288
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08389592
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08331016
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07608931
108VDR_23849224_ChIP-Seq_CD4+_Human1.06378845
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05627763
110RUNX2_22187159_ChIP-Seq_PCA_Human1.04130683
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03964944
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.03338405
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02769084
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.02769084
115SMC4_20622854_ChIP-Seq_HELA_Human1.01234762
116DPY_21335234_ChIP-Seq_ESCs_Mouse1.00899790
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98371104
118AR_20517297_ChIP-Seq_VCAP_Human0.98000585
119OCT1_27270436_Chip-Seq_PROSTATE_Human0.97431569
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97086333
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97022177
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96950009
123NANOG_20526341_ChIP-Seq_ESCs_Human0.96431677
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96261046
125* FOXH1_21741376_ChIP-Seq_EPCs_Human0.96036609
126GF1_26923725_Chip-Seq_HPCs_Mouse0.95966428
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95937880
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94663920
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.94205674
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93959275
131GF1B_26923725_Chip-Seq_HPCs_Mouse0.93954927
132FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93455424
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.93418622
134P300_19829295_ChIP-Seq_ESCs_Human0.93261501
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93257691
136RNF2_27304074_Chip-Seq_ESCs_Mouse0.92193893
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.91775021
138TCF4_23295773_ChIP-Seq_U87_Human0.91555762
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90778842
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90503262
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90467865
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90344490
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89999732
144GATA1_22025678_ChIP-Seq_K562_Human0.89999635
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89908166
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89364761
147CTCF_27219007_Chip-Seq_Bcells_Human0.89134837
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88301527
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87887115
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87730220
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86850306
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.86404820
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.86275980
154ER_23166858_ChIP-Seq_MCF-7_Human0.86254044
155SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85958024
156FOXA2_19822575_ChIP-Seq_HepG2_Human0.85200360
157EGR1_19032775_ChIP-ChIP_M12_Human0.85183068
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84719129
159TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84383423
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84293882
161EZH2_27304074_Chip-Seq_ESCs_Mouse0.84271739
162SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84070410
163EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83778708
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82120713
165JUN_21703547_ChIP-Seq_K562_Human0.80915172
166* NCOR_22424771_ChIP-Seq_293T_Human0.80144253
167CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78048293
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77949388
169ETS1_20019798_ChIP-Seq_JURKAT_Human0.77736945
170FUS_26573619_Chip-Seq_HEK293_Human0.77547226
171FLI1_27457419_Chip-Seq_LIVER_Mouse0.75235001
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73838181
173SMAD3_21741376_ChIP-Seq_EPCs_Human0.73723033
174* SALL4_22934838_ChIP-ChIP_CD34+_Human0.73341163
175SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72858550
176THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72834496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis7.14689688
2MP0005253_abnormal_eye_physiology7.02284290
3MP0003718_maternal_effect6.98909775
4MP0008877_abnormal_DNA_methylation5.70115571
5MP0002090_abnormal_vision3.82397284
6* MP0005195_abnormal_posterior_eye3.68129550
7MP0005391_vision/eye_phenotype3.37876172
8MP0002139_abnormal_hepatobiliary_system3.35801973
9MP0003950_abnormal_plasma_membrane3.31929052
10MP0001324_abnormal_eye_pigmentation3.17067787
11MP0003693_abnormal_embryo_hatching2.85970165
12MP0002229_neurodegeneration2.77596337
13MP0005395_other_phenotype2.73211197
14MP0008058_abnormal_DNA_repair2.56649556
15MP0001929_abnormal_gametogenesis2.47996922
16MP0002210_abnormal_sex_determination2.43919160
17MP0005423_abnormal_somatic_nervous2.40253816
18MP0003699_abnormal_female_reproductive2.10638165
19MP0001764_abnormal_homeostasis2.05900912
20MP0003011_delayed_dark_adaptation10.3708184
21* MP0005551_abnormal_eye_electrophysiolog10.1298062
22MP0002160_abnormal_reproductive_system1.99824100
23MP0002638_abnormal_pupillary_reflex1.94989312
24MP0003121_genomic_imprinting1.93377240
25MP0000653_abnormal_sex_gland1.91652877
26* MP0002752_abnormal_somatic_nervous1.78643046
27MP0001986_abnormal_taste_sensitivity1.76379366
28MP0010094_abnormal_chromosome_stability1.73876527
29MP0002138_abnormal_hepatobiliary_system1.73500892
30MP0010030_abnormal_orbit_morphology1.72038485
31MP0005410_abnormal_fertilization1.69963629
32MP0002234_abnormal_pharynx_morphology1.64686152
33MP0001145_abnormal_male_reproductive1.64615726
34MP0002161_abnormal_fertility/fecundity1.62540771
35MP0005503_abnormal_tendon_morphology1.60537154
36MP0001188_hyperpigmentation1.59938396
37MP0003111_abnormal_nucleus_morphology1.59890967
38MP0002653_abnormal_ependyma_morphology1.58747141
39MP0004019_abnormal_vitamin_homeostasis1.56981847
40MP0003698_abnormal_male_reproductive1.54895868
41MP0008057_abnormal_DNA_replication1.54198580
42MP0005389_reproductive_system_phenotype1.52491934
43MP0003879_abnormal_hair_cell1.52438425
44MP0006276_abnormal_autonomic_nervous1.50326609
45MP0000427_abnormal_hair_cycle1.47191109
46MP0003077_abnormal_cell_cycle1.45908448
47MP0001119_abnormal_female_reproductive1.45284379
48MP0004233_abnormal_muscle_weight1.40842807
49MP0005360_urolithiasis1.31302751
50* MP0002882_abnormal_neuron_morphology1.30799466
51MP0001501_abnormal_sleep_pattern1.25312014
52MP0008004_abnormal_stomach_pH1.21313024
53MP0008932_abnormal_embryonic_tissue1.13311205
54MP0001293_anophthalmia1.11018990
55MP0003136_yellow_coat_color1.03670229
56MP0002233_abnormal_nose_morphology1.03419160
57MP0002735_abnormal_chemical_nociception0.99615854
58MP0000383_abnormal_hair_follicle0.96501788
59MP0000566_synostosis0.96083855
60MP0010678_abnormal_skin_adnexa0.95845008
61MP0004270_analgesia0.94994805
62MP0003786_premature_aging0.94820226
63MP0005645_abnormal_hypothalamus_physiol0.94335750
64MP0008995_early_reproductive_senescence0.93845632
65MP0001502_abnormal_circadian_rhythm0.92644631
66MP0000465_gastrointestinal_hemorrhage0.91860496
67MP0001486_abnormal_startle_reflex0.91509188
68MP0001730_embryonic_growth_arrest0.90642993
69MP0010307_abnormal_tumor_latency0.90330942
70MP0000049_abnormal_middle_ear0.88711785
71MP0001984_abnormal_olfaction0.85172572
72MP0003183_abnormal_peptide_metabolism0.84956525
73MP0009840_abnormal_foam_cell0.83596423
74MP0002102_abnormal_ear_morphology0.82516972
75MP0003119_abnormal_digestive_system0.81734086
76MP0004142_abnormal_muscle_tone0.81432917
77MP0010386_abnormal_urinary_bladder0.76351821
78MP0004885_abnormal_endolymph0.74919236
79MP0000678_abnormal_parathyroid_gland0.72747546
80MP0005197_abnormal_uvea_morphology0.72565235
81MP0008875_abnormal_xenobiotic_pharmacok0.71082104
82MP0005647_abnormal_sex_gland0.70459345
83MP0002751_abnormal_autonomic_nervous0.68853996
84MP0002332_abnormal_exercise_endurance0.68346959
85MP0000350_abnormal_cell_proliferation0.66312568
86MP0001919_abnormal_reproductive_system0.66274582
87MP0001664_abnormal_digestion0.64755161
88MP0003634_abnormal_glial_cell0.64234511
89MP0005174_abnormal_tail_pigmentation0.58938288
90MP0002734_abnormal_mechanical_nocicepti0.58515742
91MP0002127_abnormal_cardiovascular_syste0.57953255
92MP0000015_abnormal_ear_pigmentation0.57477560
93MP0009780_abnormal_chondrocyte_physiolo0.57134754
94MP0002909_abnormal_adrenal_gland0.56730441
95MP0006292_abnormal_olfactory_placode0.56324860
96MP0005187_abnormal_penis_morphology0.55437200
97MP0000762_abnormal_tongue_morphology0.55426618
98MP0002272_abnormal_nervous_system0.54899821
99MP0000372_irregular_coat_pigmentation0.54884994
100MP0002095_abnormal_skin_pigmentation0.54868604
101MP0005365_abnormal_bile_salt0.54546910
102MP0002822_catalepsy0.51249511
103MP0005386_behavior/neurological_phenoty0.50750568
104MP0004924_abnormal_behavior0.50750568
105MP0000358_abnormal_cell_content/0.49533672
106MP0005085_abnormal_gallbladder_physiolo0.49328272
107MP0001968_abnormal_touch/_nociception0.49264122
108MP0010234_abnormal_vibrissa_follicle0.49200550
109MP0002572_abnormal_emotion/affect_behav0.49134774
110MP0003635_abnormal_synaptic_transmissio0.49133196
111MP0002064_seizures0.48220829
112MP0004859_abnormal_synaptic_plasticity0.47527526
113MP0005376_homeostasis/metabolism_phenot0.46185611
114MP0003045_fibrosis0.45779786
115MP0001963_abnormal_hearing_physiology0.45277117
116MP0001286_abnormal_eye_development0.43786012
117MP0005499_abnormal_olfactory_system0.43011210
118MP0005394_taste/olfaction_phenotype0.43011210
119MP0004043_abnormal_pH_regulation0.42641566
120MP0002877_abnormal_melanocyte_morpholog0.42587662
121MP0002063_abnormal_learning/memory/cond0.41836290
122MP0003252_abnormal_bile_duct0.41809891
123MP0005076_abnormal_cell_differentiation0.39858823
124MP0000631_abnormal_neuroendocrine_gland0.38704901
125MP0003890_abnormal_embryonic-extraembry0.38329997
126MP0004742_abnormal_vestibular_system0.36386138
127MP0001944_abnormal_pancreas_morphology0.33958046
128MP0002067_abnormal_sensory_capabilities0.33341502
129MP0005620_abnormal_muscle_contractility0.31818200
130MP0009745_abnormal_behavioral_response0.31664300
131MP0004085_abnormal_heartbeat0.29942860
132MP0004215_abnormal_myocardial_fiber0.29503535
133MP0010368_abnormal_lymphatic_system0.29141519
134MP0003075_altered_response_to0.29052907
135MP0003283_abnormal_digestive_organ0.28688561
136MP0001905_abnormal_dopamine_level0.27823159
137MP0008789_abnormal_olfactory_epithelium0.26513247
138MP0003880_abnormal_central_pattern0.25378348
139MP0004145_abnormal_muscle_electrophysio0.24535571
140MP0005330_cardiomyopathy0.23618906
141MP0001915_intracranial_hemorrhage0.22475017
142MP0001879_abnormal_lymphatic_vessel0.21642289
143MP0005220_abnormal_exocrine_pancreas0.21359647
144MP0002928_abnormal_bile_duct0.21333008
145MP0008569_lethality_at_weaning0.20967512
146MP0009046_muscle_twitch0.20291579
147MP0002078_abnormal_glucose_homeostasis0.20061240
148MP0002066_abnormal_motor_capabilities/c0.19968420
149MP0003638_abnormal_response/metabolism_0.19519776
150MP0001661_extended_life_span0.19296659
151MP0002693_abnormal_pancreas_physiology0.19269786
152MP0005646_abnormal_pituitary_gland0.19106720
153MP0003705_abnormal_hypodermis_morpholog0.18206916
154MP0001299_abnormal_eye_distance/0.17833796
155MP0000749_muscle_degeneration0.17746286
156MP0008872_abnormal_physiological_respon0.17573238
157MP0005535_abnormal_body_temperature0.17212052
158MP0003172_abnormal_lysosome_physiology0.16955183
159MP0002972_abnormal_cardiac_muscle0.16942495
160MP0002152_abnormal_brain_morphology0.16606007
161MP0002971_abnormal_brown_adipose0.16489913
162MP0010329_abnormal_lipoprotein_level0.15727551
163MP0005334_abnormal_fat_pad0.15237273
164MP0003868_abnormal_feces_composition0.14742175
165MP0003953_abnormal_hormone_level0.13202208
166MP0003943_abnormal_hepatobiliary_system0.12482008

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.91292068
2Abnormality of macular pigmentation (HP:0008002)9.50393417
3Abnormal rod and cone electroretinograms (HP:0008323)8.97399353
4Pigmentary retinal degeneration (HP:0001146)8.71054796
5Central scotoma (HP:0000603)7.89893531
6Pendular nystagmus (HP:0012043)7.23446906
7Decreased central vision (HP:0007663)7.06006039
8Scotoma (HP:0000575)6.97113893
9Attenuation of retinal blood vessels (HP:0007843)6.87475303
10Vitreoretinal degeneration (HP:0000655)6.73184760
11Abolished electroretinogram (ERG) (HP:0000550)6.50886629
12Chorioretinal atrophy (HP:0000533)6.01279709
13Supernumerary spleens (HP:0009799)5.91233211
14* Photophobia (HP:0000613)5.71002848
15Macular degeneration (HP:0000608)5.47034581
16Severe visual impairment (HP:0001141)5.41424170
17Posterior subcapsular cataract (HP:0007787)5.17055039
18Type II diabetes mellitus (HP:0005978)5.00367195
19Choroideremia (HP:0001139)4.73939569
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.71328254
21Abnormal gallbladder physiology (HP:0012438)4.63384396
22Cholecystitis (HP:0001082)4.63384396
23Abnormality of the labia minora (HP:0012880)4.23935800
24Facial hemangioma (HP:0000329)4.12883384
25Constricted visual fields (HP:0001133)4.06578144
26Septo-optic dysplasia (HP:0100842)4.01148126
27Anterior segment dysgenesis (HP:0007700)3.89313074
28Abdominal situs inversus (HP:0003363)3.86993453
29Abnormality of abdominal situs (HP:0011620)3.86993453
30Cone-rod dystrophy (HP:0000548)3.84022576
31Impulsivity (HP:0100710)3.82683170
32Retinitis pigmentosa (HP:0000510)3.79346564
33Keratoconus (HP:0000563)3.63379353
34Increased corneal curvature (HP:0100692)3.63379353
35Azoospermia (HP:0000027)3.59390291
36Osteomalacia (HP:0002749)3.49912250
37Chromsome breakage (HP:0040012)3.32506364
38Ulnar claw (HP:0001178)3.28926788
39Congenital sensorineural hearing impairment (HP:0008527)3.24019782
40Aplasia of the musculature (HP:0100854)3.22371648
41Retinal atrophy (HP:0001105)3.14446228
42Subcapsular cataract (HP:0000523)3.13015944
43Decreased electroretinogram (ERG) amplitude (HP:0000654)3.07162007
44Median cleft lip (HP:0000161)3.04112087
45Lip pit (HP:0100267)3.01648794
46Absent septum pellucidum (HP:0001331)2.95814458
47Abnormal spermatogenesis (HP:0008669)2.95206120
48Papillary thyroid carcinoma (HP:0002895)2.94595288
49Infertility (HP:0000789)2.85278576
50Oligodactyly (HP:0012165)2.84859050
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80161527
52Optic disc pallor (HP:0000543)2.77808643
53Optic nerve hypoplasia (HP:0000609)2.73112953
54Hypophosphatemic rickets (HP:0004912)2.72643688
55Gonadotropin excess (HP:0000837)2.71167666
56Progressive visual loss (HP:0000529)2.69054510
57Volvulus (HP:0002580)2.63035166
58Male infertility (HP:0003251)2.59600277
59Short tibia (HP:0005736)2.57232113
60Maternal diabetes (HP:0009800)2.53697954
61Lower limb hyperreflexia (HP:0002395)2.53287112
62Abnormality of the septum pellucidum (HP:0007375)2.51837732
63Shoulder girdle muscle weakness (HP:0003547)2.49156618
64Capillary hemangiomas (HP:0005306)2.45338385
65Peripheral hypomyelination (HP:0007182)2.37657478
66Apathy (HP:0000741)2.36194261
67Myokymia (HP:0002411)2.35479909
68Diminished motivation (HP:0000745)2.33372574
69Generalized aminoaciduria (HP:0002909)2.31536846
70Birth length less than 3rd percentile (HP:0003561)2.26085909
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.25117500
72Metaphyseal dysplasia (HP:0100255)2.24365972
73Abnormal biliary tract physiology (HP:0012439)2.19836074
74Bile duct proliferation (HP:0001408)2.19836074
75Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19417903
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16861328
77Wrist flexion contracture (HP:0001239)2.15368702
78Wide nasal bridge (HP:0000431)2.14837130
79Horizontal nystagmus (HP:0000666)2.14595714
80Abnormality of chromosome stability (HP:0003220)2.13912004
81Fair hair (HP:0002286)2.12788599
82Abnormality of the vocal cords (HP:0008777)2.11974967
83Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05103957
84Peritonitis (HP:0002586)2.04149619
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.02181481
86Premature ovarian failure (HP:0008209)2.00031610
87Dyschromatopsia (HP:0007641)16.7354711
88Congenital stationary night blindness (HP:0007642)12.7839783
89Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3771416
90Truncal obesity (HP:0001956)1.97546931
91Anomalous pulmonary venous return (HP:0010772)1.96286540
92Gait imbalance (HP:0002141)1.94257997
93Aplasia/Hypoplasia of the macula (HP:0008059)1.92379211
94Proximal tubulopathy (HP:0000114)1.92113186
95Congenital primary aphakia (HP:0007707)1.91841930
96Elevated erythrocyte sedimentation rate (HP:0003565)1.90732381
97Abnormal lung lobation (HP:0002101)1.90305440
98Pili torti (HP:0003777)1.89657404
99Severe Myopia (HP:0011003)1.88790107
100Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88457505
101Abnormality of the labia (HP:0000058)1.88031176
102Amyotrophic lateral sclerosis (HP:0007354)1.87993544
103Absent thumb (HP:0009777)1.86200180
104Small intestinal stenosis (HP:0012848)1.85229241
105Duodenal stenosis (HP:0100867)1.85229241
106Type II lissencephaly (HP:0007260)1.80229055
107Atrophy/Degeneration involving motor neurons (HP:0007373)1.80053252
108Small hand (HP:0200055)1.78399909
109Hypokinesia (HP:0002375)1.75411086
110Amblyopia (HP:0000646)1.75008182
111Aplasia/Hypoplasia affecting the retina (HP:0008061)1.74303698
112Prolonged neonatal jaundice (HP:0006579)1.72975209
113Hyperglycinemia (HP:0002154)1.69794372
114Abnormal ciliary motility (HP:0012262)1.69285362
115Abnormality of the renal cortex (HP:0011035)1.68570056
116Polar cataract (HP:0010696)1.66823397
117Abnormal hair whorl (HP:0010721)1.66563940
118Nephrogenic diabetes insipidus (HP:0009806)1.66372297
119Medial flaring of the eyebrow (HP:0010747)1.61624428
120Poor coordination (HP:0002370)1.49536701
121Dysdiadochokinesis (HP:0002075)1.41484319
122Optic atrophy (HP:0000648)1.40726938
123Vaginal atresia (HP:0000148)1.29639253
124Retinal detachment (HP:0000541)1.25029314
125Genital tract atresia (HP:0001827)1.23582996
126Interstitial pulmonary disease (HP:0006530)1.17454211
127Epileptic encephalopathy (HP:0200134)1.16369500
128Truncal ataxia (HP:0002078)1.07014638
129Genetic anticipation (HP:0003743)1.06372887
130True hermaphroditism (HP:0010459)1.05935741
131Pancreatic fibrosis (HP:0100732)1.05370682
132Aplasia/Hypoplasia of the lens (HP:0008063)1.02991699
133Macroorchidism (HP:0000053)1.02671995
134Progressive cerebellar ataxia (HP:0002073)1.00339237
135Febrile seizures (HP:0002373)0.94402202
136Cystic liver disease (HP:0006706)0.87545231
137Left ventricular hypertrophy (HP:0001712)0.86269520
138Hyperventilation (HP:0002883)0.85154343
139Astigmatism (HP:0000483)0.84902505
140Pancreatic cysts (HP:0001737)0.84898076
141Prolonged QT interval (HP:0001657)0.84846764
142Chorioretinal coloboma (HP:0000567)0.84408223
143Anal stenosis (HP:0002025)0.83880076
144Broad foot (HP:0001769)0.80035636
145Visual hallucinations (HP:0002367)0.76064235
146Abnormality of midbrain morphology (HP:0002418)0.76015181
147Molar tooth sign on MRI (HP:0002419)0.76015181
148Hypermetropia (HP:0000540)0.74924757
149Oligodactyly (hands) (HP:0001180)0.74747765
150Broad-based gait (HP:0002136)0.74020460
151Dysmetric saccades (HP:0000641)0.73926337
152Aplasia/Hypoplasia of the tongue (HP:0010295)0.72408354
153Specific learning disability (HP:0001328)0.70263943
154Asthma (HP:0002099)0.69870704
155Furrowed tongue (HP:0000221)0.68633504
156Sclerocornea (HP:0000647)0.66462253
157Cerebellar dysplasia (HP:0007033)0.66200529
158Decreased testicular size (HP:0008734)0.63950224
159Abnormal EKG (HP:0003115)0.63051279
160Lymphopenia (HP:0001888)0.63050939
161Abnormality of the fingertips (HP:0001211)0.62612805
162Aqueductal stenosis (HP:0002410)0.62479952
163Corneal dystrophy (HP:0001131)0.61989290
164Gaze-evoked nystagmus (HP:0000640)0.61495769
165Absent speech (HP:0001344)0.60744400
166Chronic hepatic failure (HP:0100626)0.60482570
167Scanning speech (HP:0002168)0.60359962
168Abnormality of the fovea (HP:0000493)0.60228012
169Generalized myoclonic seizures (HP:0002123)0.59939931
170Abnormality of the parathyroid morphology (HP:0011766)0.59668758
171Hypoventilation (HP:0002791)0.59588175
172Syncope (HP:0001279)0.56282880
173Hypoplasia of the fovea (HP:0007750)0.56044753
174Aplasia/Hypoplasia of the fovea (HP:0008060)0.56044753
175Abnormality of cells of the lymphoid lineage (HP:0012140)0.55890549
176Dental crowding (HP:0000678)0.55337611
177Recurrent sinusitis (HP:0011108)0.55291320
178Anencephaly (HP:0002323)0.55026283
179Urinary bladder sphincter dysfunction (HP:0002839)0.54500169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.68966319
2MAP3K94.51333942
3ARAF4.13004859
4MAP3K134.03120967
5MAP4K23.45212349
6BMPR1B2.63068541
7CDK192.58179693
8PINK12.52125811
9ADRBK12.33706810
10BRAF2.25639994
11NEK62.21171367
12CDC72.20434081
13AURKA2.16277512
14INSRR2.15914538
15GRK111.5315888
16CAMK1G1.95690767
17HIPK21.95363670
18TRIM281.90911816
19STK241.84373187
20CDK121.80428474
21MYLK1.78866763
22MET1.77663067
23PRKCI1.73975105
24MAPK71.72730804
25MAP3K121.70781214
26MAPK121.66890758
27MST41.60723193
28CAMK1D1.60394001
29OXSR11.56158745
30NTRK21.55519446
31MOS1.55164926
32BRD41.55029802
33PRKD31.54759634
34EPHB21.51337694
35ZAK1.49106488
36CSNK1G11.46072540
37SIK21.41910131
38KSR11.40135855
39RPS6KA41.39475003
40PLK11.38910110
41MAP3K41.38874095
42TAOK31.36600758
43CDK81.33758115
44STK381.31742386
45CSNK1G31.30648962
46RAF11.30322805
47LATS11.29835088
48PNCK1.28427279
49BUB11.27715095
50TLK11.21905392
51CSNK1D1.16767880
52TNIK1.09468463
53WNK31.08241006
54AKT31.05114645
55MAP3K51.04138765
56PRKCH1.03953589
57SRPK11.01184266
58TTK0.96072383
59CDK70.95921482
60SGK20.93292927
61FRK0.92400183
62TNK20.91611270
63STK38L0.90747462
64CSNK1A1L0.90693184
65MARK10.89750366
66ATR0.89185180
67SGK2230.87862749
68SGK4940.87862749
69ERBB20.87630546
70WNK10.84841209
71KSR20.84431367
72SGK30.84400282
73PKN10.83927009
74IRAK20.83607571
75FES0.82528545
76STK30.82170924
77PHKG20.79763149
78PHKG10.79763149
79ATM0.79731147
80PAK60.78175712
81NUAK10.77904003
82PIM10.77072958
83BRSK10.75085552
84AURKB0.74979480
85MARK30.73041238
86ICK0.72355485
87VRK10.71903226
88CAMKK10.71821390
89CAMK2D0.71501887
90PRKCB0.70479543
91MAPK130.68909428
92PRKCZ0.68774395
93DMPK0.67272371
94EIF2AK30.65437932
95CHEK10.65050966
96PAK10.63869031
97CDK20.63837493
98PRKG10.63817702
99PRKACG0.61124177
100MELK0.59156362
101RPS6KA30.59120544
102BCKDK0.58936006
103ERN10.58467544
104SIK10.57265015
105NTRK30.56912457
106EPHA40.56634119
107CDK50.56307181
108PRKAA10.55734563
109PRKAA20.55508911
110STK390.55042499
111MAPK150.54264065
112BCR0.53655608
113MAP3K20.53445638
114MAP3K100.53172700
115ADRBK20.51716138
116PRKACB0.50064701
117PLK20.49418316
118WNK40.45725077
119PRKDC0.45031111
120MAP2K40.44862544
121MAP3K70.44579019
122GSK3B0.43333588
123CDK150.43179939
124MAP2K70.42403937
125CDK90.42347368
126DYRK1A0.41912644
127CAMK10.41863360
128CDK180.41599170
129CDK11A0.41592148
130CDK140.41159615
131CAMK40.41063776
132CHUK0.40783740
133DYRK1B0.40540868
134TSSK60.40021054
135MAPK90.39365264
136MAPK100.39140604
137MAPK140.38738394
138TGFBR10.38552437
139ALK0.38515310
140AKT20.38109926
141PRKD20.37892974
142MINK10.37133815
143IRAK10.36482039
144SGK10.35237231
145PLK30.33859306
146MAP3K80.33452124
147CLK10.33252807
148YES10.32903524
149CHEK20.32504095
150CSNK1G20.32379741
151TIE10.32344538
152PRKACA0.32318486
153RET0.32075067
154GRK50.32046619
155RPS6KB10.31839894
156NEK20.31009923
157MAPK30.30762843
158SCYL20.30619841
159CSNK2A20.30575173
160CDC42BPA0.30124336
161CSNK2A10.29960617
162FGFR30.29451141
163CDK10.27799503
164EGFR0.27603588
165STK110.26978120
166PTK20.26434313
167RPS6KA20.25092078
168PAK20.24988086
169PRKD10.24355295
170MTOR0.23180844
171PRKCA0.23013397
172CAMK2A0.22833929
173JAK10.22732163
174CSNK1E0.22546291
175CDK30.22121120
176RPS6KA50.21927786

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.50650931
2Base excision repair_Homo sapiens_hsa034103.73108039
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.63493609
4Cell cycle_Homo sapiens_hsa041103.40818081
5RNA degradation_Homo sapiens_hsa030183.17421661
6Mismatch repair_Homo sapiens_hsa034303.06320821
7Oocyte meiosis_Homo sapiens_hsa041142.92896528
8Homologous recombination_Homo sapiens_hsa034402.87393069
9Fanconi anemia pathway_Homo sapiens_hsa034602.39524855
10Ovarian steroidogenesis_Homo sapiens_hsa049132.30394790
11Caffeine metabolism_Homo sapiens_hsa002322.20106312
12DNA replication_Homo sapiens_hsa030302.16957984
13Nucleotide excision repair_Homo sapiens_hsa034202.02890100
14RNA transport_Homo sapiens_hsa030132.00678916
15* Phototransduction_Homo sapiens_hsa0474415.8847182
16Folate biosynthesis_Homo sapiens_hsa007901.86015592
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76237075
18RNA polymerase_Homo sapiens_hsa030201.72844345
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66170206
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.62191651
21Collecting duct acid secretion_Homo sapiens_hsa049661.62047423
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47492954
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40830320
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37445650
25Olfactory transduction_Homo sapiens_hsa047401.30805666
26Synaptic vesicle cycle_Homo sapiens_hsa047211.24743997
27Regulation of autophagy_Homo sapiens_hsa041401.16369145
28Taste transduction_Homo sapiens_hsa047421.14870841
29Oxidative phosphorylation_Homo sapiens_hsa001901.14594573
30Huntingtons disease_Homo sapiens_hsa050161.14171276
31p53 signaling pathway_Homo sapiens_hsa041151.13609213
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12232087
33Non-homologous end-joining_Homo sapiens_hsa034501.10378507
34Dorso-ventral axis formation_Homo sapiens_hsa043201.07235468
35GABAergic synapse_Homo sapiens_hsa047271.00896893
36Parkinsons disease_Homo sapiens_hsa050120.94213060
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90084833
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87366325
39mRNA surveillance pathway_Homo sapiens_hsa030150.84312749
40Cholinergic synapse_Homo sapiens_hsa047250.81595333
41Selenocompound metabolism_Homo sapiens_hsa004500.81413002
42Spliceosome_Homo sapiens_hsa030400.80517895
43Dopaminergic synapse_Homo sapiens_hsa047280.77768190
44Circadian rhythm_Homo sapiens_hsa047100.77494291
45Proteasome_Homo sapiens_hsa030500.76854398
46Steroid biosynthesis_Homo sapiens_hsa001000.76666225
47Propanoate metabolism_Homo sapiens_hsa006400.74877108
48Pyrimidine metabolism_Homo sapiens_hsa002400.73049398
49Purine metabolism_Homo sapiens_hsa002300.72100040
50Glutamatergic synapse_Homo sapiens_hsa047240.70442612
51Serotonergic synapse_Homo sapiens_hsa047260.68481215
52ABC transporters_Homo sapiens_hsa020100.67962146
53Morphine addiction_Homo sapiens_hsa050320.67958279
54Circadian entrainment_Homo sapiens_hsa047130.67040880
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66486736
56Arginine and proline metabolism_Homo sapiens_hsa003300.66236686
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65788300
58Retinol metabolism_Homo sapiens_hsa008300.65141586
59Insulin secretion_Homo sapiens_hsa049110.64890933
60Protein export_Homo sapiens_hsa030600.63326303
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60880223
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59190648
63Fatty acid elongation_Homo sapiens_hsa000620.56129603
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53811199
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.53605498
66TGF-beta signaling pathway_Homo sapiens_hsa043500.51055436
67Phagosome_Homo sapiens_hsa041450.49279452
68Herpes simplex infection_Homo sapiens_hsa051680.48423762
69Ether lipid metabolism_Homo sapiens_hsa005650.47477602
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47161351
71Linoleic acid metabolism_Homo sapiens_hsa005910.46854004
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45280415
73Nitrogen metabolism_Homo sapiens_hsa009100.41967186
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41487074
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39810908
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.39517764
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39331597
78Cocaine addiction_Homo sapiens_hsa050300.36912806
79Glycerolipid metabolism_Homo sapiens_hsa005610.35846349
80Gastric acid secretion_Homo sapiens_hsa049710.35577854
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35330133
82cAMP signaling pathway_Homo sapiens_hsa040240.34548398
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34270335
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34231709
85Oxytocin signaling pathway_Homo sapiens_hsa049210.34158782
86Renin secretion_Homo sapiens_hsa049240.32299826
87Long-term potentiation_Homo sapiens_hsa047200.31217187
88Arginine biosynthesis_Homo sapiens_hsa002200.30540683
89Salivary secretion_Homo sapiens_hsa049700.29179936
90Glucagon signaling pathway_Homo sapiens_hsa049220.29089573
91Dilated cardiomyopathy_Homo sapiens_hsa054140.28936689
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28480617
93Lysine degradation_Homo sapiens_hsa003100.27567206
94Metabolic pathways_Homo sapiens_hsa011000.27491335
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25825486
96Nicotine addiction_Homo sapiens_hsa050330.25182053
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25165845
98Amphetamine addiction_Homo sapiens_hsa050310.25049207
99Calcium signaling pathway_Homo sapiens_hsa040200.24927263
100Type II diabetes mellitus_Homo sapiens_hsa049300.23922588
101Alzheimers disease_Homo sapiens_hsa050100.22280974
102Cardiac muscle contraction_Homo sapiens_hsa042600.22084919
103mTOR signaling pathway_Homo sapiens_hsa041500.20966382
104Vitamin digestion and absorption_Homo sapiens_hsa049770.20537693
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.19719253
106Pancreatic secretion_Homo sapiens_hsa049720.18751781
107Bile secretion_Homo sapiens_hsa049760.18442753
108Pyruvate metabolism_Homo sapiens_hsa006200.17307133
109Alcoholism_Homo sapiens_hsa050340.17071825
110Insulin resistance_Homo sapiens_hsa049310.16851573
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16147451
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.16103865
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15973461
114Fructose and mannose metabolism_Homo sapiens_hsa000510.15679235
115Long-term depression_Homo sapiens_hsa047300.15420643
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15077991
117Fatty acid metabolism_Homo sapiens_hsa012120.14850466
118Thyroid hormone synthesis_Homo sapiens_hsa049180.14445764
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13142114
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12723376
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12214068
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11816414
123Galactose metabolism_Homo sapiens_hsa000520.11018968
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10741476
125AMPK signaling pathway_Homo sapiens_hsa041520.10635467
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10044946
127Rheumatoid arthritis_Homo sapiens_hsa053230.09385264
128Sulfur relay system_Homo sapiens_hsa041220.09376168
129Inositol phosphate metabolism_Homo sapiens_hsa005620.09046002
130Chemokine signaling pathway_Homo sapiens_hsa040620.08954359
131N-Glycan biosynthesis_Homo sapiens_hsa005100.08894636
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08657679
133Glioma_Homo sapiens_hsa052140.08541595
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.08265217
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08015430
136HIF-1 signaling pathway_Homo sapiens_hsa040660.07786921
137Sphingolipid metabolism_Homo sapiens_hsa006000.07592555
138Ras signaling pathway_Homo sapiens_hsa040140.07409987
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07327212
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07145171
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.07114681
142Vibrio cholerae infection_Homo sapiens_hsa051100.06607031
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06186191
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05752374
145GnRH signaling pathway_Homo sapiens_hsa049120.05595015
146Biosynthesis of amino acids_Homo sapiens_hsa012300.05253586
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05008939
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.04816681
149MAPK signaling pathway_Homo sapiens_hsa040100.04545930
150Starch and sucrose metabolism_Homo sapiens_hsa005000.04460250
151Peroxisome_Homo sapiens_hsa041460.03821871
152Endocytosis_Homo sapiens_hsa041440.03753358
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03618856
154Tight junction_Homo sapiens_hsa045300.03605632
155Thyroid cancer_Homo sapiens_hsa052160.03232869
156Wnt signaling pathway_Homo sapiens_hsa043100.03226791
157Protein digestion and absorption_Homo sapiens_hsa049740.02233233
158Insulin signaling pathway_Homo sapiens_hsa049100.01705112
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.01503835
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00595878
161Gap junction_Homo sapiens_hsa045400.00371573
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.00085963

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