GNAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)9.49297655
2negative regulation of catenin import into nucleus (GO:0035414)8.84181072
3production of molecular mediator involved in inflammatory response (GO:0002532)8.45886084
4specification of organ identity (GO:0010092)7.98017924
5regulation of catenin import into nucleus (GO:0035412)7.72763785
6positive regulation of catenin import into nucleus (GO:0035413)7.66461841
7response to hydroperoxide (GO:0033194)7.50193648
8dorsal/ventral axis specification (GO:0009950)7.13788596
9receptor catabolic process (GO:0032801)6.97836802
10inflammatory response to antigenic stimulus (GO:0002437)6.77919377
11response to methylmercury (GO:0051597)6.37037860
12granulocyte differentiation (GO:0030851)5.89272477
13photoreceptor cell differentiation (GO:0046530)5.87303284
14eye photoreceptor cell differentiation (GO:0001754)5.87303284
15positive regulation of epithelial to mesenchymal transition (GO:0010718)5.81634519
16cranial suture morphogenesis (GO:0060363)5.59449883
17protoporphyrinogen IX biosynthetic process (GO:0006782)5.56464421
18tooth mineralization (GO:0034505)5.51754694
19arachidonic acid secretion (GO:0050482)5.27110529
20icosanoid secretion (GO:0032309)5.27110529
21response to insecticide (GO:0017085)5.24010384
22response to fungus (GO:0009620)5.13792799
23positive regulation of dendritic spine morphogenesis (GO:0061003)4.98158743
24positive regulation of vesicle fusion (GO:0031340)4.90179182
25protoporphyrinogen IX metabolic process (GO:0046501)4.87564348
26hepatocyte apoptotic process (GO:0097284)4.84333356
27lipoxygenase pathway (GO:0019372)4.69276239
28innate immune response in mucosa (GO:0002227)4.61244269
29low-density lipoprotein particle clearance (GO:0034383)4.54552748
30regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.53997448
31viral transcription (GO:0019083)4.53020732
32bone trabecula formation (GO:0060346)4.50381254
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43254685
34icosanoid transport (GO:0071715)4.42541282
35fatty acid derivative transport (GO:1901571)4.42541282
36translational termination (GO:0006415)4.36019587
37positive regulation of male gonad development (GO:2000020)4.25421148
38response to lead ion (GO:0010288)4.23145336
39negative regulation of bone mineralization (GO:0030502)4.18577109
40regulation of male gonad development (GO:2000018)4.18273536
41ribosomal small subunit biogenesis (GO:0042274)4.17636707
42layer formation in cerebral cortex (GO:0021819)4.13939248
43maturation of SSU-rRNA (GO:0030490)4.11213966
44otic vesicle formation (GO:0030916)4.06325019
45nuclear pore organization (GO:0006999)4.05123555
46nuclear pore complex assembly (GO:0051292)4.03458830
47regulation of macrophage cytokine production (GO:0010935)3.99754938
48translational elongation (GO:0006414)3.99738376
49regulation of translational fidelity (GO:0006450)3.90964866
50negative regulation of interleukin-8 production (GO:0032717)3.89438219
51mucosal immune response (GO:0002385)3.88879632
52L-serine transport (GO:0015825)3.84951233
53negative regulation of biomineral tissue development (GO:0070168)3.84740850
54positive regulation of guanylate cyclase activity (GO:0031284)3.80594027
55dendritic spine organization (GO:0097061)3.75898598
56retinal cone cell development (GO:0046549)3.75806399
57positive regulation of hair cycle (GO:0042635)3.74694610
58positive regulation of hair follicle development (GO:0051798)3.74694610
59ribosomal small subunit assembly (GO:0000028)3.74404353
60cellular protein complex localization (GO:0034629)3.74316540
61regulation of rhodopsin mediated signaling pathway (GO:0022400)3.73331841
62negative regulation of epidermal cell differentiation (GO:0045605)3.70115985
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67263200
64cotranslational protein targeting to membrane (GO:0006613)3.66562920
65cellular response to antibiotic (GO:0071236)3.65045450
66regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.59977712
67positive regulation of stem cell differentiation (GO:2000738)3.58987961
68protein targeting to ER (GO:0045047)3.53805884
69icosanoid biosynthetic process (GO:0046456)3.53638471
70fatty acid derivative biosynthetic process (GO:1901570)3.53638471
71epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.51522322
72response to phenylpropanoid (GO:0080184)3.48658172
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47921709
74viral life cycle (GO:0019058)3.46718515
75negative regulation of T cell differentiation in thymus (GO:0033085)3.44992351
76leukotriene biosynthetic process (GO:0019370)3.44863320
77respiratory tube development (GO:0030323)3.44177031
78antibacterial humoral response (GO:0019731)3.43946354
79organ or tissue specific immune response (GO:0002251)3.42809121
80neutrophil activation involved in immune response (GO:0002283)3.42070428
81rhodopsin mediated signaling pathway (GO:0016056)3.41360125
82biotin metabolic process (GO:0006768)3.40587551
83pattern specification involved in kidney development (GO:0061004)3.39923370
84positive regulation of macrophage cytokine production (GO:0060907)3.39510233
85endocardial cushion morphogenesis (GO:0003203)3.38977179
86mesenchymal cell differentiation involved in renal system development (GO:2001012)3.38875781
87mesenchymal cell differentiation involved in kidney development (GO:0072161)3.38875781
88regulation of T cell cytokine production (GO:0002724)3.37153734
89cellular protein complex disassembly (GO:0043624)3.36885417
90collecting duct development (GO:0072044)3.35884441
91regulation of guanylate cyclase activity (GO:0031282)3.34253805
92regulation of Rap GTPase activity (GO:0032317)3.33883253
93regulation of cell proliferation involved in kidney development (GO:1901722)3.31632465
94protein localization to endoplasmic reticulum (GO:0070972)3.30036801
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28304046
96craniofacial suture morphogenesis (GO:0097094)3.26404417
97fatty acid transmembrane transport (GO:1902001)3.26027075
98serine transport (GO:0032329)3.25831870
99pore complex assembly (GO:0046931)3.25624598
100natural killer cell mediated immunity (GO:0002228)3.25335775
101natural killer cell mediated cytotoxicity (GO:0042267)3.25335775
102regulation of interleukin-8 secretion (GO:2000482)3.22904173
103ribosomal large subunit biogenesis (GO:0042273)3.21969808
104translational initiation (GO:0006413)3.21916321
105mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.20175646
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19548380
107Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.16837686
108positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.16290802
109cGMP-mediated signaling (GO:0019934)3.15348213
110regulation of mesenchymal cell apoptotic process (GO:2001053)3.10381099
111dendritic cell chemotaxis (GO:0002407)3.09720289
112negative regulation of metanephros development (GO:0072217)3.08988976
113hemidesmosome assembly (GO:0031581)3.08908796
114parturition (GO:0007567)3.07981595
115cell surface receptor signaling pathway involved in heart development (GO:0061311)3.05031310
116leukotriene metabolic process (GO:0006691)3.04392854
117photoreceptor cell development (GO:0042461)3.04016136
118positive regulation of monocyte chemotaxis (GO:0090026)3.03997162
119antimicrobial humoral response (GO:0019730)3.01974942
120nephron tubule formation (GO:0072079)3.01537607
121maintenance of gastrointestinal epithelium (GO:0030277)3.01125347
122mRNA stabilization (GO:0048255)3.00806139
123RNA stabilization (GO:0043489)3.00806139
124eye photoreceptor cell development (GO:0042462)2.99483844
125regulation of establishment of planar polarity (GO:0090175)2.98406912
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94529233
127protein complex disassembly (GO:0043241)2.94030141
128microtubule severing (GO:0051013)2.93115294
129negative regulation of epidermis development (GO:0045683)2.91420244
130activation of MAPKKK activity (GO:0000185)2.90750974
131protein retention in ER lumen (GO:0006621)2.90278803
132wound healing, spreading of epidermal cells (GO:0035313)2.89730656
133myeloid dendritic cell differentiation (GO:0043011)2.89617674
134phagocytosis, recognition (GO:0006910)2.89236936
135macromolecular complex disassembly (GO:0032984)2.89224003
136response to lipoprotein particle (GO:0055094)2.89006070
137establishment of epithelial cell polarity (GO:0090162)2.88824377
138glomerular visceral epithelial cell development (GO:0072015)2.88681786
139skin morphogenesis (GO:0043589)2.88230691
140embryonic skeletal joint morphogenesis (GO:0060272)2.87104334
141regulation of myeloid cell apoptotic process (GO:0033032)2.85303514
142regulation of epithelial to mesenchymal transition (GO:0010717)2.85059435
143hepatocyte differentiation (GO:0070365)2.85024164
144negative regulation of cytokine production involved in immune response (GO:0002719)2.84957593
145arachidonic acid metabolic process (GO:0019369)2.84820455
146protein complex localization (GO:0031503)2.84451994
147positive regulation of extracellular matrix organization (GO:1903055)2.84167587
148termination of signal transduction (GO:0023021)2.83338563
149epithelial structure maintenance (GO:0010669)2.80729845
150detection of light stimulus involved in sensory perception (GO:0050962)2.79823429
151detection of light stimulus involved in visual perception (GO:0050908)2.79823429
152mast cell activation (GO:0045576)2.78320760
153male sex determination (GO:0030238)2.78274533
154formation of translation preinitiation complex (GO:0001731)2.77827447
155eosinophil chemotaxis (GO:0048245)2.77032128
156cellular component maintenance (GO:0043954)2.76961744
157ribonucleoprotein complex biogenesis (GO:0022613)2.75938663
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75878159
159mitochondrion transport along microtubule (GO:0047497)2.75878159
160inositol phosphate dephosphorylation (GO:0046855)2.75054907
161phosphorylated carbohydrate dephosphorylation (GO:0046838)2.75054907
162positive regulation of epidermis development (GO:0045684)2.74809637
163regulation of chromosome segregation (GO:0051983)2.74454413
164regulation of hair follicle development (GO:0051797)2.74012131
165cyclooxygenase pathway (GO:0019371)2.72169801
166regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.69879070
167positive regulation of T cell cytokine production (GO:0002726)2.69408302
168response to progesterone (GO:0032570)2.69137296
169mast cell activation involved in immune response (GO:0002279)2.65294753
170mast cell degranulation (GO:0043303)2.65294753
171myeloid dendritic cell activation (GO:0001773)2.64908671
172cellular response to vitamin D (GO:0071305)2.64650965
173cellular response to toxic substance (GO:0097237)2.61594198
174long-chain fatty acid transport (GO:0015909)2.60317372
175long term synaptic depression (GO:0060292)2.58747384
176phototransduction (GO:0007602)2.58328368
177immunoglobulin mediated immune response (GO:0016064)2.56523337
178antigen processing and presentation via MHC class Ib (GO:0002475)2.56415768
179termination of G-protein coupled receptor signaling pathway (GO:0038032)2.55670716
180regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.52697969
181heart valve formation (GO:0003188)2.50931523
182positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50902131
183regulation of cytokine production involved in immune response (GO:0002718)2.48730465
184phospholipid scrambling (GO:0017121)2.48723193
185leukocyte degranulation (GO:0043299)2.48000138
186positive regulation of fatty acid beta-oxidation (GO:0032000)2.47194967
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.46297273
188inositol phosphate catabolic process (GO:0071545)2.45703418
189* sensory perception of taste (GO:0050909)2.45401972
190phototransduction, visible light (GO:0007603)2.44059552
191positive regulation of bone remodeling (GO:0046852)2.43052497
192positive regulation of bone resorption (GO:0045780)2.43052497
193prostanoid biosynthetic process (GO:0046457)2.42962104
194prostaglandin biosynthetic process (GO:0001516)2.42962104
195positive regulation of type 2 immune response (GO:0002830)2.42512067
196Rap protein signal transduction (GO:0032486)2.41597939
197regulation of water loss via skin (GO:0033561)2.41595587
198* detection of light stimulus (GO:0009583)2.41141857
199secondary heart field specification (GO:0003139)12.2396695
200heart field specification (GO:0003128)12.2396695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.51279300
2E2F7_22180533_ChIP-Seq_HELA_Human7.78353418
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human6.33304911
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.07470610
5GATA1_22025678_ChIP-Seq_K562_Human4.59727369
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.25504671
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.75134567
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.46344617
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.00213933
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63705837
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62111805
12IRF1_19129219_ChIP-ChIP_H3396_Human2.59325886
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.56977211
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30694309
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30067390
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29860888
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.29748015
18AR_21909140_ChIP-Seq_LNCAP_Human2.20389063
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.16468384
20CNOT3_19339689_ChIP-ChIP_MESCs_Mouse2.08772372
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07925929
22AR_21572438_ChIP-Seq_LNCaP_Human2.06554894
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03589765
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.02017352
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01151849
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.00893523
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97802642
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.94764959
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91272888
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90220845
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88548461
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86424002
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80529995
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79700836
35ZNF263_19887448_ChIP-Seq_K562_Human1.78754994
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77183114
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.74790545
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.73527972
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70977174
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.70437725
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68447270
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67862245
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63701833
44SOX2_20726797_ChIP-Seq_SW620_Human1.63281911
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62267462
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61260716
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60897279
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57779107
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57445109
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57339897
51* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51583050
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50856890
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.49354435
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48020861
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46735422
56RUNX_20019798_ChIP-Seq_JUKART_Human1.46382574
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45666614
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45294568
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45294568
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45099611
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45064763
62* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44653835
63TP53_18474530_ChIP-ChIP_U2OS_Human1.44422929
64TP53_16413492_ChIP-PET_HCT116_Human1.43162082
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42771685
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42370259
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42032935
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41695505
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.40620343
70SCL_19346495_ChIP-Seq_HPC-7_Human1.39632817
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39501520
72DROSHA_22980978_ChIP-Seq_HELA_Human1.38194968
73XRN2_22483619_ChIP-Seq_HELA_Human1.36559250
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36356648
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35518974
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34251055
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34089632
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33047370
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.32008796
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31224503
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30979948
82DCP1A_22483619_ChIP-Seq_HELA_Human1.30837409
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30444728
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29158306
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29034274
86* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28140182
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27631130
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.27094492
89* GATA4_25053715_ChIP-Seq_YYC3_Human1.24952459
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24937369
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24305249
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23929641
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23314391
94TTF2_22483619_ChIP-Seq_HELA_Human1.22690544
95VDR_24787735_ChIP-Seq_THP-1_Human1.21094022
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20665225
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20519540
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.20517219
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19888218
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19519628
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19288147
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17626076
103MYC_18940864_ChIP-ChIP_HL60_Human1.16968375
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16283064
105IGF1R_20145208_ChIP-Seq_DFB_Human1.15349334
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14933145
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14927121
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.11566970
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11514110
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09447087
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07456866
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07206337
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06744031
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06689738
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.06638399
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06452376
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06452376
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06438755
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06313243
120LXR_22158963_ChIP-Seq_LIVER_Mouse1.06034337
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05922350
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05659090
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05061676
124RXR_22108803_ChIP-Seq_LS180_Human1.04633219
125STAT1_20625510_ChIP-Seq_HELA_Human1.03581909
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03239045
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02996257
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02298556
129TCF7_22412390_ChIP-Seq_EML_Mouse1.02072999
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99918919
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99124164
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98919268
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98704011
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98435964
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98064208
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.96011339
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95605549
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95468828
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95389440
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95079717
141* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94368641
142* CJUN_26792858_Chip-Seq_BT549_Human0.94291115
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92940529
144CLOCK_20551151_ChIP-Seq_293T_Human0.92671841
145SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91592045
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.90460844
147SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90087205
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.89482647
149* TP63_23658742_ChIP-Seq_EP156T_Human0.88982673
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87729842
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87719228
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86921434
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.86561833
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86413843
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86247760
156RACK7_27058665_Chip-Seq_MCF-7_Human0.85978194
157ZNF274_21170338_ChIP-Seq_K562_Hela0.85305724
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85089820
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85072835
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84991080
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84887177
162TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83676505
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83661633
164SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83500429
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83441186
166LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83425282
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82893586
168GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82892140
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82156857
170ATF3_27146783_Chip-Seq_COLON_Human0.82091573
171UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81518020
172IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81023524
173CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80992544
174ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80461810
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80206750
176KDM2B_26808549_Chip-Seq_K562_Human0.79820949
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79291397
178RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79274392
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79030894
180CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78484922
181TCF4_18268006_ChIP-ChIP_LS174T_Human0.78426359
182SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78398068
183TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76462768
184TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75838733
185SOX2_18692474_ChIP-Seq_MESCs_Mouse0.75457883
186REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74908670
187EP300_21415370_ChIP-Seq_HL-1_Mouse0.74796896
188CHD1_26751641_Chip-Seq_LNCaP_Human0.74610086
189TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73705097
190KDM5A_27292631_Chip-Seq_BREAST_Human0.72556328
191KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72079481
192SOX2_16153702_ChIP-ChIP_HESCs_Human0.72066115
193ETS1_20019798_ChIP-Seq_JURKAT_Human0.71851995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002148_abnormal_hypersensitivity_rea5.77565281
2MP0008004_abnormal_stomach_pH5.41567299
3MP0002735_abnormal_chemical_nociception4.52227374
4MP0009379_abnormal_foot_pigmentation3.92053556
5MP0002254_reproductive_system_inflammat3.76497883
6MP0003436_decreased_susceptibility_to3.67921524
7MP0005257_abnormal_intraocular_pressure3.58652315
8MP0002098_abnormal_vibrissa_morphology3.21192390
9MP0003195_calcinosis3.08560527
10MP0000427_abnormal_hair_cycle2.87537463
11MP0000516_abnormal_urinary_system2.86440644
12MP0005367_renal/urinary_system_phenotyp2.86440644
13MP0003123_paternal_imprinting2.84883896
14MP0010352_gastrointestinal_tract_polyps2.65224574
15MP0005000_abnormal_immune_tolerance2.58407756
16MP0002009_preneoplasia2.57563780
17MP0003303_peritoneal_inflammation2.39863506
18MP0003693_abnormal_embryo_hatching2.38881672
19MP0001835_abnormal_antigen_presentation2.30811459
20MP0008057_abnormal_DNA_replication2.26351405
21MP0000490_abnormal_crypts_of2.26153618
22MP0010155_abnormal_intestine_physiology2.21275197
23MP0010678_abnormal_skin_adnexa2.19894715
24* MP0001986_abnormal_taste_sensitivity2.19841976
25MP0000538_abnormal_urinary_bladder2.05169440
26MP0002092_abnormal_eye_morphology1.99040769
27MP0005551_abnormal_eye_electrophysiolog1.96391382
28MP0002168_other_aberrant_phenotype1.94906068
29MP0001346_abnormal_lacrimal_gland1.89381750
30MP0002796_impaired_skin_barrier1.88677988
31MP0003638_abnormal_response/metabolism_1.86940994
32MP0002405_respiratory_system_inflammati1.85205061
33MP0002876_abnormal_thyroid_physiology1.83756778
34MP0006082_CNS_inflammation1.83193685
35MP0003300_gastrointestinal_ulcer1.81654971
36MP0005501_abnormal_skin_physiology1.80967511
37MP0005464_abnormal_platelet_physiology1.79403092
38MP0010234_abnormal_vibrissa_follicle1.78608004
39MP0005310_abnormal_salivary_gland1.77531440
40MP0004510_myositis1.76199932
41MP0000685_abnormal_immune_system1.75435592
42MP0000579_abnormal_nail_morphology1.74244396
43MP0010386_abnormal_urinary_bladder1.72571491
44MP0002734_abnormal_mechanical_nocicepti1.71801280
45MP0005253_abnormal_eye_physiology1.69912630
46MP0002419_abnormal_innate_immunity1.68358327
47MP0003075_altered_response_to1.66455897
48MP0003890_abnormal_embryonic-extraembry1.65695929
49MP0001533_abnormal_skeleton_physiology1.64043966
50MP0003705_abnormal_hypodermis_morpholog1.63307142
51MP0005025_abnormal_response_to1.60436429
52MP0004957_abnormal_blastocyst_morpholog1.59390067
53MP0001800_abnormal_humoral_immune1.58687863
54MP0001790_abnormal_immune_system1.58042745
55MP0005387_immune_system_phenotype1.58042745
56MP0000377_abnormal_hair_follicle1.55075875
57MP0005395_other_phenotype1.54675773
58MP0001845_abnormal_inflammatory_respons1.53373600
59MP0005671_abnormal_response_to1.52802773
60MP0004264_abnormal_extraembryonic_tissu1.47027094
61MP0002452_abnormal_antigen_presenting1.45081181
62MP0000383_abnormal_hair_follicle1.43952891
63MP0003385_abnormal_body_wall1.43868661
64MP0004134_abnormal_chest_morphology1.39448165
65MP0000537_abnormal_urethra_morphology1.38807998
66MP0002111_abnormal_tail_morphology1.36736374
67MP0001984_abnormal_olfaction1.36560119
68MP0005423_abnormal_somatic_nervous1.36521918
69MP0002822_catalepsy1.36430938
70MP0009764_decreased_sensitivity_to1.36239589
71MP0003724_increased_susceptibility_to1.35140829
72MP0002723_abnormal_immune_serum1.34252846
73MP0002060_abnormal_skin_morphology1.33357601
74MP0002733_abnormal_thermal_nociception1.32835129
75MP0005023_abnormal_wound_healing1.32651168
76MP0004130_abnormal_muscle_cell1.32529067
77MP0005645_abnormal_hypothalamus_physiol1.30188219
78MP0009785_altered_susceptibility_to1.29642714
79MP0002736_abnormal_nociception_after1.29328373
80MP0001849_ear_inflammation1.28786953
81MP0001819_abnormal_immune_cell1.26738473
82MP0005166_decreased_susceptibility_to1.25428543
83MP0002420_abnormal_adaptive_immunity1.23311189
84MP0001188_hyperpigmentation1.22512165
85MP0010094_abnormal_chromosome_stability1.21887657
86MP0003172_abnormal_lysosome_physiology1.20720148
87MP0001348_abnormal_lacrimal_gland1.20610532
88MP0008469_abnormal_protein_level1.16957521
89MP0005365_abnormal_bile_salt1.15721200
90MP0002295_abnormal_pulmonary_circulatio1.15028439
91MP0000762_abnormal_tongue_morphology1.14403802
92MP0003077_abnormal_cell_cycle1.13920791
93MP0003566_abnormal_cell_adhesion1.13205845
94MP0010771_integument_phenotype1.12837301
95MP0005058_abnormal_lysosome_morphology1.12063522
96MP0002163_abnormal_gland_morphology1.11109439
97MP0000534_abnormal_ureter_morphology1.10992205
98MP0009763_increased_sensitivity_to1.10848261
99MP0003315_abnormal_perineum_morphology1.09458176
100MP0001851_eye_inflammation1.07719364
101MP0000343_altered_response_to1.07376863
102MP0003937_abnormal_limbs/digits/tail_de1.07273584
103MP0000955_abnormal_spinal_cord1.06951638
104MP0001727_abnormal_embryo_implantation1.05861451
105MP0001216_abnormal_epidermal_layer1.05668267
106MP0003045_fibrosis1.05038460
107MP0006072_abnormal_retinal_apoptosis1.04992632
108MP0000013_abnormal_adipose_tissue1.02838766
109MP0004019_abnormal_vitamin_homeostasis1.02781229
110MP0003943_abnormal_hepatobiliary_system1.02360966
111MP0001666_abnormal_nutrient_absorption1.01889414
112MP0002928_abnormal_bile_duct1.00922337
113MP0009765_abnormal_xenobiotic_induced1.00749660
114MP0004782_abnormal_surfactant_physiolog1.00695810
115MP0005379_endocrine/exocrine_gland_phen1.00629574
116MP0002084_abnormal_developmental_patter1.00291498
117MP0005391_vision/eye_phenotype0.99266894
118MP0001853_heart_inflammation0.96811845
119MP0003011_delayed_dark_adaptation0.96045550
120MP0002697_abnormal_eye_size0.96022967
121MP0003718_maternal_effect0.95902783
122MP0004858_abnormal_nervous_system0.93653122
123MP0001968_abnormal_touch/_nociception0.92183320
124MP0003111_abnormal_nucleus_morphology0.91311608
125MP0003806_abnormal_nucleotide_metabolis0.91074628
126MP0010329_abnormal_lipoprotein_level0.89821842
127MP0001970_abnormal_pain_threshold0.88728652
128MP0003787_abnormal_imprinting0.88308624
129MP0002234_abnormal_pharynx_morphology0.86881235
130MP0003755_abnormal_palate_morphology0.86620158
131MP0003950_abnormal_plasma_membrane0.85826236
132MP0003119_abnormal_digestive_system0.85439231
133MP0002909_abnormal_adrenal_gland0.84819324
134MP0005197_abnormal_uvea_morphology0.84677018
135MP0002877_abnormal_melanocyte_morpholog0.84497095
136MP0008874_decreased_physiological_sensi0.83831164
137MP0002116_abnormal_craniofacial_bone0.83380013
138MP0003221_abnormal_cardiomyocyte_apopto0.80429106
139MP0001765_abnormal_ion_homeostasis0.79670133
140MP0008058_abnormal_DNA_repair0.79269041
141MP0003448_altered_tumor_morphology0.78468976
142MP0002166_altered_tumor_susceptibility0.77934668
143MP0004036_abnormal_muscle_relaxation0.77419672
144MP0002233_abnormal_nose_morphology0.76679762
145MP0002006_tumorigenesis0.76366592
146MP0009643_abnormal_urine_homeostasis0.75619553
147MP0006035_abnormal_mitochondrial_morpho0.75492140
148MP0005409_darkened_coat_color0.75157205
149MP0005084_abnormal_gallbladder_morpholo0.73801609
150MP0001672_abnormal_embryogenesis/_devel0.73704432
151MP0005380_embryogenesis_phenotype0.73704432
152MP0002896_abnormal_bone_mineralization0.73339284
153MP0004742_abnormal_vestibular_system0.72723700
154MP0008932_abnormal_embryonic_tissue0.72004434
155MP0000767_abnormal_smooth_muscle0.71873126
156MP0005390_skeleton_phenotype0.71697867
157MP0009780_abnormal_chondrocyte_physiolo0.71409590
158MP0005164_abnormal_response_to0.71102007
159MP0000470_abnormal_stomach_morphology0.71069815
160MP0002184_abnormal_innervation0.71057508
161MP0001293_anophthalmia0.69772248
162MP0004185_abnormal_adipocyte_glucose0.68698999
163MP0003329_amyloid_beta_deposits0.68193671
164MP0000477_abnormal_intestine_morphology0.67386808
165MP0004947_skin_inflammation0.67325068
166MP0003453_abnormal_keratinocyte_physiol0.66926901
167MP0003091_abnormal_cell_migration0.66660670
168MP0001529_abnormal_vocalization0.66539152
169MP0000627_abnormal_mammary_gland0.66472372
170MP0002138_abnormal_hepatobiliary_system0.66042856
171MP0004484_altered_response_of0.65994314
172MP0005195_abnormal_posterior_eye0.65500628
173MP0003880_abnormal_central_pattern0.65344322
174MP0002837_dystrophic_cardiac_calcinosis0.65280237
175MP0002090_abnormal_vision0.65142088
176MP0000432_abnormal_head_morphology0.63213337
177MP0006138_congestive_heart_failure0.62618345
178MP0003984_embryonic_growth_retardation0.62250437
179MP0005360_urolithiasis0.61337622
180MP0002085_abnormal_embryonic_tissue0.61195229
181MP0000358_abnormal_cell_content/0.60591877
182MP0000747_muscle_weakness0.60407268
183MP0000566_synostosis0.60080703
184MP0004270_analgesia0.60079780
185MP0001697_abnormal_embryo_size0.59775917
186MP0003861_abnormal_nervous_system0.59391653
187MP0002088_abnormal_embryonic_growth/wei0.59134288
188MP0002160_abnormal_reproductive_system0.58525110
189MP0002752_abnormal_somatic_nervous0.57624383
190MP0005193_abnormal_anterior_eye0.57231956
191MP0009053_abnormal_anal_canal0.56353172
192MP0008775_abnormal_heart_ventricle0.56019141
193MP0000681_abnormal_thyroid_gland0.55110408
194MP0002882_abnormal_neuron_morphology0.54937708

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.30215074
2Insomnia (HP:0100785)8.50671572
3Right ventricular cardiomyopathy (HP:0011663)5.98069470
4Pili torti (HP:0003777)5.89046346
5Diaphragmatic weakness (HP:0009113)5.28696961
6Sex reversal (HP:0012245)5.21755938
7Abnormal sex determination (HP:0012244)5.21755938
8Oligodontia (HP:0000677)5.20414629
9Decreased central vision (HP:0007663)5.14471853
10Recurrent gram-negative bacterial infections (HP:0005420)4.84702079
11Aplasia cutis congenita (HP:0001057)4.74168542
12Sparse scalp hair (HP:0002209)4.58526767
13Elfin facies (HP:0004428)4.56408317
14Overriding aorta (HP:0002623)4.41713507
15Pigmentary retinal degeneration (HP:0001146)4.35093681
16Leiomyosarcoma (HP:0100243)4.31027163
17Uterine leiomyosarcoma (HP:0002891)4.31027163
18Microglossia (HP:0000171)4.29668841
19Anhidrosis (HP:0000970)4.17030030
20Hyperacusis (HP:0010780)4.10881810
21Premature loss of primary teeth (HP:0006323)4.01683172
22True hermaphroditism (HP:0010459)4.00707842
23Abnormality of the gastric mucosa (HP:0004295)3.97052645
24Renovascular hypertension (HP:0100817)3.81930341
25Hereditary nonpolyposis colorectal carcinoma (HP:0006716)3.79894530
26Transitional cell carcinoma of the bladder (HP:0006740)3.74437732
27Abnormality of the parietal bone (HP:0002696)3.74434303
28Dysmetric saccades (HP:0000641)3.71292031
29Interstitial pulmonary disease (HP:0006530)3.70090835
30Renal duplication (HP:0000075)3.69694743
31Premature skin wrinkling (HP:0100678)3.67875535
32Ankyloglossia (HP:0010296)3.60997079
33Bladder carcinoma (HP:0002862)3.59926858
34Bladder neoplasm (HP:0009725)3.59926858
35Confusion (HP:0001289)3.54051237
36Sparse eyelashes (HP:0000653)3.53497734
37Adrenal hypoplasia (HP:0000835)3.40022745
38Malignant gastrointestinal tract tumors (HP:0006749)3.35766243
39Gastrointestinal carcinoma (HP:0002672)3.35766243
40Esophageal varix (HP:0002040)3.28874315
41Recurrent abscess formation (HP:0002722)3.21597127
42Eczematoid dermatitis (HP:0000976)3.20988814
43Attenuation of retinal blood vessels (HP:0007843)3.20001351
44Neonatal short-limb short stature (HP:0008921)3.14582931
45Flat cornea (HP:0007720)3.14231280
46Neoplasm of the colon (HP:0100273)3.13580855
47Abnormal hair laboratory examination (HP:0003328)3.13044634
48Chronic sinusitis (HP:0011109)3.12623848
4911 pairs of ribs (HP:0000878)3.08282983
50Abnormality of liposaccharide metabolism (HP:0010968)3.06894015
51Abnormality of glycosphingolipid metabolism (HP:0004343)3.06894015
52Abnormality of glycolipid metabolism (HP:0010969)3.06894015
53Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06790839
54Amniotic constriction ring (HP:0009775)3.06669431
55Abnormality of placental membranes (HP:0011409)3.06669431
56Hypotrichosis (HP:0001006)3.03260162
57Long clavicles (HP:0000890)2.97963896
58Macular degeneration (HP:0000608)2.97741216
59Abnormal rod and cone electroretinograms (HP:0008323)2.96073527
60Megalocornea (HP:0000485)2.93047078
61Abnormality of the diencephalon (HP:0010662)2.87830860
62Progressive neurologic deterioration (HP:0002344)2.86567690
63Widely patent fontanelles and sutures (HP:0004492)2.85282694
64Thick nail (HP:0001805)2.83499794
65Intestinal polyposis (HP:0200008)2.83208684
66Hypokinesia (HP:0002375)2.83177420
67Recurrent bacterial skin infections (HP:0005406)2.81920211
68Vertebral compression fractures (HP:0002953)2.80971976
69Poikiloderma (HP:0001029)2.80714886
70Reticulocytopenia (HP:0001896)2.79902316
71Gait imbalance (HP:0002141)2.78772044
72Increased IgM level (HP:0003496)2.78327101
73Congenital primary aphakia (HP:0007707)2.77523619
74Ketoacidosis (HP:0001993)2.74349235
75Abnormality of oral frenula (HP:0000190)2.72179454
76Short clavicles (HP:0000894)2.71733147
77Intestinal polyp (HP:0005266)2.64511829
78Micronodular cirrhosis (HP:0001413)2.60294004
79Bronchomalacia (HP:0002780)2.57463991
80Renal cell carcinoma (HP:0005584)2.56613441
81Vascular calcification (HP:0004934)2.55395272
82Atrophic scars (HP:0001075)2.53632269
83Pustule (HP:0200039)2.51716264
84Thin skin (HP:0000963)2.51489964
85Bony spicule pigmentary retinopathy (HP:0007737)2.50083375
86Increased nuchal translucency (HP:0010880)2.48459467
87Distal lower limb muscle weakness (HP:0009053)2.47579698
88Gingivitis (HP:0000230)2.47108157
89Dyschromatopsia (HP:0007641)2.46976058
90Palmoplantar hyperkeratosis (HP:0000972)2.44322734
91Mediastinal lymphadenopathy (HP:0100721)2.41789093
92Osteolytic defects of the hand bones (HP:0009699)2.41207483
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.41207483
94Palmar hyperkeratosis (HP:0010765)2.40998604
95Ulnar claw (HP:0001178)2.40481738
96Uterine neoplasm (HP:0010784)2.38993435
97Supranuclear gaze palsy (HP:0000605)2.38313686
98Microdontia (HP:0000691)2.38108594
99High anterior hairline (HP:0009890)2.36218251
100Mitral stenosis (HP:0001718)2.36135799
101Prolonged QT interval (HP:0001657)2.35780063
102Dysostosis multiplex (HP:0000943)2.35667127
103Cardiovascular calcification (HP:0011915)2.34565345
104Cone-rod dystrophy (HP:0000548)2.33822629
105Axonal loss (HP:0003447)2.33410470
106Aplasia/Hypoplasia of the clavicles (HP:0006710)2.33258198
107Nephrogenic diabetes insipidus (HP:0009806)2.31231639
108Abnormality of cells of the erythroid lineage (HP:0012130)2.29746759
109Milia (HP:0001056)2.28330897
110Redundant skin (HP:0001582)2.26931136
111Ventricular arrhythmia (HP:0004308)2.26716928
112Delusions (HP:0000746)2.25832765
113Medial flaring of the eyebrow (HP:0010747)2.25607477
114Respiratory distress (HP:0002098)2.20674624
115Abnormality of hair growth rate (HP:0011363)2.20339137
116Slow-growing hair (HP:0002217)2.20339137
117Abnormality of macrophages (HP:0004311)2.19870548
118Retinal atrophy (HP:0001105)2.19290895
119Generalized hyperpigmentation (HP:0007440)2.19038222
120Thickened calvaria (HP:0002684)2.17635507
121Pulmonary infiltrates (HP:0002113)2.17571847
122Onycholysis (HP:0001806)2.16021278
123Hyponatremia (HP:0002902)2.13414900
124Syncope (HP:0001279)2.12035074
125Malignant hyperthermia (HP:0002047)2.11507247
126Abnormality of renal resorption (HP:0011038)2.10768231
127Plantar hyperkeratosis (HP:0007556)2.10248725
128Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08252388
129Bowel diverticulosis (HP:0005222)2.07166443
130Glucose intolerance (HP:0000833)2.07160223
131Hypercalciuria (HP:0002150)2.05376638
132Periodontitis (HP:0000704)2.04181513
133Retinitis pigmentosa (HP:0000510)2.03091778
134Microvesicular hepatic steatosis (HP:0001414)2.03005768
135Vaginal atresia (HP:0000148)2.01795022
136Abdominal distention (HP:0003270)2.01210446
137Limb hypertonia (HP:0002509)2.00741934
138Termporal pattern (HP:0011008)2.00281829
139Insidious onset (HP:0003587)2.00281829
140Wide cranial sutures (HP:0010537)1.97314212
141Ridged nail (HP:0001807)1.96933739
142Short nail (HP:0001799)1.94935060
143Poor coordination (HP:0002370)1.94904818
144Sudden cardiac death (HP:0001645)1.94211900
145Genital tract atresia (HP:0001827)1.92820556
146Lip pit (HP:0100267)1.92345123
147Elevated erythrocyte sedimentation rate (HP:0003565)1.92269036
148Pointed chin (HP:0000307)1.88763134
149Tibial bowing (HP:0002982)1.88148335
150Abnormality of male internal genitalia (HP:0000022)1.88092968
151Progressive external ophthalmoplegia (HP:0000590)1.87810293
152Photophobia (HP:0000613)1.87730127
153Mucopolysacchariduria (HP:0008155)1.86897818
154Urinary glycosaminoglycan excretion (HP:0003541)1.86897818
155Hand muscle atrophy (HP:0009130)1.85404873
156Ragged-red muscle fibers (HP:0003200)1.85289891
157Segmental peripheral demyelination/remyelination (HP:0003481)1.85211546
158Missing ribs (HP:0000921)1.85208659
159Delayed CNS myelination (HP:0002188)1.85009015
160Abnormality of proline metabolism (HP:0010907)1.82480578
161Hydroxyprolinuria (HP:0003080)1.82480578
162Congenital, generalized hypertrichosis (HP:0004540)1.81711425
163Purpura (HP:0000979)1.81431073
164Tachypnea (HP:0002789)1.80497349
165Abnormality of the right ventricle (HP:0001707)1.80382219
166Recurrent skin infections (HP:0001581)1.79871067
167Systemic lupus erythematosus (HP:0002725)1.78732159
168Abnormality of the sella turcica (HP:0002679)1.78234476
169Type II diabetes mellitus (HP:0005978)1.76817226
170Hypoplastic toenails (HP:0001800)1.76502120
171Abnormality of the neuromuscular junction (HP:0003398)1.75719423
172Fatigable weakness (HP:0003473)1.75719423
173Focal motor seizures (HP:0011153)1.74709963
174Myokymia (HP:0002411)1.73776501
175Increased mean platelet volume (HP:0011877)1.73584832
176Focal segmental glomerulosclerosis (HP:0000097)1.73511358
177Abnormality of the carotid arteries (HP:0005344)1.73123564
178Metaphyseal dysplasia (HP:0100255)1.73042525
179Abnormal glucose tolerance (HP:0001952)1.72565458
180Abnormality of primary teeth (HP:0006481)1.72359563
181Abnormality of the preputium (HP:0100587)1.71899945
182Autoimmune thrombocytopenia (HP:0001973)1.71793203
183Hypergammaglobulinemia (HP:0010702)1.69516572
184Recurrent bronchitis (HP:0002837)1.69136786
185Aplasia/Hypoplasia of the lens (HP:0008063)1.68846061
186Tetany (HP:0001281)1.68721784
187Hypoplasia of dental enamel (HP:0006297)1.68526483
188Abnormality of polysaccharide metabolism (HP:0011012)1.68494053
189Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68494053
190Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68494053
191Abnormalities of placenta or umbilical cord (HP:0001194)1.68293821
192Cheilitis (HP:0100825)1.66994643
193Bundle branch block (HP:0011710)1.66922045
194Hypercalcemia (HP:0003072)1.66652273
195Growth hormone excess (HP:0000845)1.65063141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K6.01375821
2ERBB35.30271322
3MAPKAPK54.62821658
4ZAK3.78232188
5PIK3CG3.35900859
6KSR23.30642456
7PBK3.00064054
8MKNK12.96617315
9LATS22.95721882
10STK392.79725856
11TLK12.76118444
12TRPM72.71278753
13RAF12.69876083
14NME12.64679490
15MAPK152.64245994
16STK38L2.47160217
17SCYL22.46520122
18PHKG22.41235863
19PHKG12.41235863
20INSRR2.27082384
21EPHA22.23833615
22BMPR1B2.23794508
23RPS6KB22.21649348
24DMPK2.18668321
25SIK12.16870365
26BRAF2.10191948
27TBK12.08041706
28MAP3K102.01551766
29LATS11.99163721
30TEC1.98718425
31KSR11.90658975
32BMPR21.73064401
33ARAF1.68525301
34BLK1.67045222
35CDK31.66675503
36ERN11.59840667
37TTK1.58996951
38MAP3K141.57005381
39RPS6KA51.55490463
40EIF2AK11.54492686
41EIF2AK31.53795869
42MAP3K131.52892324
43BTK1.49153992
44MELK1.47091936
45IRAK21.45240034
46TYK21.42391448
47WNK31.42017917
48TAOK31.37027893
49MUSK1.35861876
50RIPK41.34710721
51MINK11.32933396
52EPHA41.31054150
53ITK1.28308812
54SRPK11.27190936
55CASK1.25047279
56PRKCI1.20607839
57OXSR11.20095613
58NEK21.16917684
59MAP3K121.16892392
60CCNB11.16137234
61MAP2K11.14972402
62PRPF4B1.14822690
63IKBKB1.13434480
64IKBKE1.12819818
65IRAK11.11847773
66PAK61.11573050
67CDC71.10337755
68SMG11.07453329
69AKT31.06929668
70MAP3K21.00675697
71TRIB30.97395729
72MAP3K90.96366366
73TSSK60.96242159
74MAPKAPK20.96101761
75NEK10.94532128
76EIF2AK20.91490573
77CSNK1G30.91465894
78STK30.91114865
79PAK30.88740906
80PASK0.88411785
81CDK190.88059289
82STK240.85371150
83NEK60.81999349
84CSNK1A1L0.80033940
85PLK10.79449285
86CHUK0.79019447
87TGFBR10.78921554
88DYRK30.78311943
89CHEK20.77413169
90RPS6KB10.76867010
91ABL20.76337837
92WEE10.74942606
93MATK0.72871551
94CSNK1G10.72732062
95KIT0.72452296
96EPHB10.71978773
97PTK20.71584691
98LMTK20.71519550
99CSNK1G20.71033445
100HCK0.70792513
101NTRK30.69010220
102PRKCQ0.68741431
103SYK0.68497332
104MAPK70.66144845
105CSNK1E0.66024456
106CSF1R0.65795134
107CAMK2A0.65357610
108PRKG20.62539769
109BUB10.62210024
110PKN20.61791424
111JAK20.60982847
112AURKB0.57423886
113TGFBR20.55823190
114CDK80.54529812
115STK160.54380631
116PRKAA10.53580641
117PRKCD0.53094944
118AURKA0.52450383
119NUAK10.52218195
120TYRO30.51019249
121IRAK30.50166567
122DAPK30.48896322
123RPS6KA20.47070338
124NEK90.45642604
125PKN10.45216638
126LRRK20.43931081
127BCR0.42936398
128TAF10.42377440
129CSK0.40837284
130PTK60.40236147
131VRK10.39021306
132MAP2K20.38887402
133IGF1R0.38203782
134WNK40.38054155
135IRAK40.37249782
136MST1R0.36749813
137PRKACG0.36729939
138MAP3K10.36317267
139ATR0.36219200
140CSNK2A20.36165290
141RPS6KA40.36041427
142CAMK2G0.35480675
143PRKCZ0.35105824
144EGFR0.34918309
145MAP4K10.34265287
146MAPK40.34049514
147RPS6KA10.33485407
148PLK30.33430769
149STK380.31911031
150MST40.31595712
151PRKCH0.30477275
152CDK150.30104417
153MAPKAPK30.30023427
154PIM20.29008319
155TTN0.28836012
156CAMK1D0.28745126
157MET0.28328566
158CDK180.28239931
159ABL10.28067783
160CDK20.27359109
161MAP3K80.27016222
162CDK11A0.26443220
163MOS0.24672502
164GRK10.24244925
165CAMK10.24180029
166PRKCA0.23939728
167PRKCE0.23690369
168NME20.23385500
169JAK10.22698321
170PRKACA0.21368640
171LYN0.20170301
172ADRBK20.19790386
173RPS6KA60.19023476
174SRC0.18383846
175ERBB20.18140666
176CDC42BPA0.18000979

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.96311630
2Systemic lupus erythematosus_Homo sapiens_hsa053225.35586143
3Alcoholism_Homo sapiens_hsa050344.44929043
4Ribosome_Homo sapiens_hsa030104.15244705
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.44670885
6Vitamin B6 metabolism_Homo sapiens_hsa007503.36559179
7Basal cell carcinoma_Homo sapiens_hsa052172.90023905
8TGF-beta signaling pathway_Homo sapiens_hsa043502.62324929
9Endometrial cancer_Homo sapiens_hsa052132.60201659
10Leishmaniasis_Homo sapiens_hsa051402.44959888
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29778399
12Choline metabolism in cancer_Homo sapiens_hsa052312.19680858
13DNA replication_Homo sapiens_hsa030302.16750673
14Malaria_Homo sapiens_hsa051442.09557678
15Colorectal cancer_Homo sapiens_hsa052102.05593817
16Hippo signaling pathway_Homo sapiens_hsa043902.05545093
17Arachidonic acid metabolism_Homo sapiens_hsa005902.03515827
18Wnt signaling pathway_Homo sapiens_hsa043102.01649273
19Toxoplasmosis_Homo sapiens_hsa051451.88514779
20Pyruvate metabolism_Homo sapiens_hsa006201.73865837
21Mismatch repair_Homo sapiens_hsa034301.71944912
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62782104
23Asthma_Homo sapiens_hsa053101.59554495
24Viral carcinogenesis_Homo sapiens_hsa052031.58869880
25Cell cycle_Homo sapiens_hsa041101.58504953
26Rheumatoid arthritis_Homo sapiens_hsa053231.58281309
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57890958
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54831328
29Osteoclast differentiation_Homo sapiens_hsa043801.53216682
30Non-homologous end-joining_Homo sapiens_hsa034501.50689706
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48849418
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47120995
33Dorso-ventral axis formation_Homo sapiens_hsa043201.42042487
34B cell receptor signaling pathway_Homo sapiens_hsa046621.41012491
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40468691
36Nucleotide excision repair_Homo sapiens_hsa034201.37014026
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.36865060
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.35872402
39Amoebiasis_Homo sapiens_hsa051461.34873170
40Tuberculosis_Homo sapiens_hsa051521.33291732
41Serotonergic synapse_Homo sapiens_hsa047261.32323778
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32279048
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30867972
44African trypanosomiasis_Homo sapiens_hsa051431.30672321
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28026487
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26906298
47Linoleic acid metabolism_Homo sapiens_hsa005911.25942257
48N-Glycan biosynthesis_Homo sapiens_hsa005101.21877465
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21048148
50VEGF signaling pathway_Homo sapiens_hsa043701.20136748
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19121738
52Arginine biosynthesis_Homo sapiens_hsa002201.17877401
53Allograft rejection_Homo sapiens_hsa053301.16998027
54Legionellosis_Homo sapiens_hsa051341.16960857
55RNA polymerase_Homo sapiens_hsa030201.16226367
56RNA transport_Homo sapiens_hsa030131.14164404
57Lysosome_Homo sapiens_hsa041421.14051061
58Ovarian steroidogenesis_Homo sapiens_hsa049131.14013514
59Staphylococcus aureus infection_Homo sapiens_hsa051501.12576067
60TNF signaling pathway_Homo sapiens_hsa046681.12110796
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10968055
62Carbon metabolism_Homo sapiens_hsa012001.08782319
63Type II diabetes mellitus_Homo sapiens_hsa049301.08694238
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07388292
65Platelet activation_Homo sapiens_hsa046111.06057374
66Influenza A_Homo sapiens_hsa051641.03331600
67Long-term depression_Homo sapiens_hsa047301.02922275
68Phagosome_Homo sapiens_hsa041451.01645127
69Pentose phosphate pathway_Homo sapiens_hsa000301.01312169
70Selenocompound metabolism_Homo sapiens_hsa004501.00709573
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00627583
72Steroid biosynthesis_Homo sapiens_hsa001000.98916038
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98741774
74Chemokine signaling pathway_Homo sapiens_hsa040620.98628511
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96950001
76Parkinsons disease_Homo sapiens_hsa050120.95701145
77Propanoate metabolism_Homo sapiens_hsa006400.94552056
78Pertussis_Homo sapiens_hsa051330.94083664
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93226984
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.92756580
81Graft-versus-host disease_Homo sapiens_hsa053320.92453811
82Apoptosis_Homo sapiens_hsa042100.91752142
83Renal cell carcinoma_Homo sapiens_hsa052110.90313022
84Glycerolipid metabolism_Homo sapiens_hsa005610.89533379
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.89188115
86Ether lipid metabolism_Homo sapiens_hsa005650.87641424
87Basal transcription factors_Homo sapiens_hsa030220.86891343
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86447380
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86026265
90Type I diabetes mellitus_Homo sapiens_hsa049400.85814181
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.85520033
92Fat digestion and absorption_Homo sapiens_hsa049750.84600836
93Other glycan degradation_Homo sapiens_hsa005110.82114434
94Notch signaling pathway_Homo sapiens_hsa043300.81491070
95Salmonella infection_Homo sapiens_hsa051320.81488644
96Vibrio cholerae infection_Homo sapiens_hsa051100.81299845
97Axon guidance_Homo sapiens_hsa043600.80355227
98Pancreatic cancer_Homo sapiens_hsa052120.80089099
99Oxidative phosphorylation_Homo sapiens_hsa001900.78366906
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78285068
101Viral myocarditis_Homo sapiens_hsa054160.76571598
102GnRH signaling pathway_Homo sapiens_hsa049120.76206802
103Antigen processing and presentation_Homo sapiens_hsa046120.75610857
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.74789701
105Insulin resistance_Homo sapiens_hsa049310.73862666
106Thyroid cancer_Homo sapiens_hsa052160.69079121
107Hepatitis C_Homo sapiens_hsa051600.68837367
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68729945
109Biosynthesis of amino acids_Homo sapiens_hsa012300.68515860
110Base excision repair_Homo sapiens_hsa034100.68193803
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66644212
112Hepatitis B_Homo sapiens_hsa051610.66545674
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66447801
114Measles_Homo sapiens_hsa051620.66237539
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.65785190
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.65463043
117AMPK signaling pathway_Homo sapiens_hsa041520.65454861
118Proteasome_Homo sapiens_hsa030500.65421837
119Pyrimidine metabolism_Homo sapiens_hsa002400.65272615
120Arginine and proline metabolism_Homo sapiens_hsa003300.65014808
121Huntingtons disease_Homo sapiens_hsa050160.65013699
122Lysine degradation_Homo sapiens_hsa003100.60966013
123Folate biosynthesis_Homo sapiens_hsa007900.60259584
124* Taste transduction_Homo sapiens_hsa047420.60256694
125Chronic myeloid leukemia_Homo sapiens_hsa052200.59596181
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59339767
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59312652
128ECM-receptor interaction_Homo sapiens_hsa045120.59190166
129Acute myeloid leukemia_Homo sapiens_hsa052210.58622572
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58583498
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57987815
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57872722
133Oocyte meiosis_Homo sapiens_hsa041140.56904055
134p53 signaling pathway_Homo sapiens_hsa041150.55002946
135Bladder cancer_Homo sapiens_hsa052190.54607562
136Proteoglycans in cancer_Homo sapiens_hsa052050.53432096
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53285985
138mTOR signaling pathway_Homo sapiens_hsa041500.51086274
139Inositol phosphate metabolism_Homo sapiens_hsa005620.48989341
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48864674
141Purine metabolism_Homo sapiens_hsa002300.48680194
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.47664947
143Estrogen signaling pathway_Homo sapiens_hsa049150.46325645
144Pancreatic secretion_Homo sapiens_hsa049720.44825785
145Complement and coagulation cascades_Homo sapiens_hsa046100.44694515
146Prion diseases_Homo sapiens_hsa050200.44655248
147Tryptophan metabolism_Homo sapiens_hsa003800.44432899
148Hedgehog signaling pathway_Homo sapiens_hsa043400.44340392
149Sulfur metabolism_Homo sapiens_hsa009200.43592882
150MAPK signaling pathway_Homo sapiens_hsa040100.42768051
151One carbon pool by folate_Homo sapiens_hsa006700.42484494
152Synaptic vesicle cycle_Homo sapiens_hsa047210.41738050
153Prolactin signaling pathway_Homo sapiens_hsa049170.41722144
154Collecting duct acid secretion_Homo sapiens_hsa049660.41401088
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41219115
156Sphingolipid metabolism_Homo sapiens_hsa006000.41203137
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.41088864
158Olfactory transduction_Homo sapiens_hsa047400.41086787
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40745219
160Non-small cell lung cancer_Homo sapiens_hsa052230.40173260
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.39447855
162Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39434298
163Cholinergic synapse_Homo sapiens_hsa047250.38684051
164Fatty acid degradation_Homo sapiens_hsa000710.38141382
165T cell receptor signaling pathway_Homo sapiens_hsa046600.38001831
166Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37881752
167Metabolic pathways_Homo sapiens_hsa011000.37266071
168Alzheimers disease_Homo sapiens_hsa050100.36859771
169Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33447095
170ErbB signaling pathway_Homo sapiens_hsa040120.33085319
171Maturity onset diabetes of the young_Homo sapiens_hsa049500.32348729
172Insulin signaling pathway_Homo sapiens_hsa049100.29841028
173Homologous recombination_Homo sapiens_hsa034400.29536053
174Sulfur relay system_Homo sapiens_hsa041220.27613873
175Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24866809
176Fatty acid biosynthesis_Homo sapiens_hsa000610.24007298
177MicroRNAs in cancer_Homo sapiens_hsa052060.20687283
178Pathways in cancer_Homo sapiens_hsa052000.18482455
179Fanconi anemia pathway_Homo sapiens_hsa034600.17890264
180Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17618715
181Shigellosis_Homo sapiens_hsa051310.17336511
182Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14818828
183Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14349492
184Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13438960

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