GNAZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)7.39622867
2postsynaptic membrane organization (GO:0001941)7.03335403
3presynaptic membrane organization (GO:0097090)6.38506881
4positive regulation of protein kinase C signaling (GO:0090037)6.11233652
5regulation of protein kinase A signaling (GO:0010738)5.45304306
6pyrimidine nucleobase catabolic process (GO:0006208)5.26150435
7neuronal action potential propagation (GO:0019227)5.10428271
8neuron cell-cell adhesion (GO:0007158)5.04605066
9melanin metabolic process (GO:0006582)5.01924009
10melanin biosynthetic process (GO:0042438)4.99686990
11protein localization to synapse (GO:0035418)4.98299014
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71324436
13neuronal ion channel clustering (GO:0045161)4.54363923
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49222788
15negative regulation of execution phase of apoptosis (GO:1900118)4.44652884
16short-term memory (GO:0007614)4.42339198
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.38061043
18nucleobase catabolic process (GO:0046113)4.35354580
19vocalization behavior (GO:0071625)4.19034019
20behavioral response to nicotine (GO:0035095)4.12228721
21axonal fasciculation (GO:0007413)4.08687045
22secondary metabolite biosynthetic process (GO:0044550)4.05584926
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00583446
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.98877701
25regulation of protein kinase C signaling (GO:0090036)3.97624801
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.88494290
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81232830
28regulation of glutamate receptor signaling pathway (GO:1900449)3.76132407
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.72941006
30substrate-independent telencephalic tangential migration (GO:0021826)3.69717521
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.69717521
32righting reflex (GO:0060013)3.59788980
33regulation of synaptic vesicle exocytosis (GO:2000300)3.58851073
34positive regulation of membrane potential (GO:0045838)3.54742598
35dendritic spine morphogenesis (GO:0060997)3.53534839
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.53035957
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51136063
38glycogen catabolic process (GO:0005980)3.48131044
39GMP metabolic process (GO:0046037)3.48049023
40glutamate receptor signaling pathway (GO:0007215)3.48045625
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47342695
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46972432
43establishment of mitochondrion localization (GO:0051654)3.43804727
44neurotransmitter-gated ion channel clustering (GO:0072578)3.43012950
45regulation of synapse structural plasticity (GO:0051823)3.42667183
46synaptic transmission, glutamatergic (GO:0035249)3.37330952
47cerebellar granule cell differentiation (GO:0021707)3.36649273
48cerebellar Purkinje cell differentiation (GO:0021702)3.36226258
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35278458
50synaptic vesicle maturation (GO:0016188)3.31953211
51long-term memory (GO:0007616)3.30309283
52synaptic vesicle exocytosis (GO:0016079)3.30183536
53positive regulation of dendritic spine development (GO:0060999)3.27556447
54positive regulation of synapse assembly (GO:0051965)3.24662039
55glucan catabolic process (GO:0009251)3.24593807
56cell migration in hindbrain (GO:0021535)3.19343474
57membrane assembly (GO:0071709)3.17323253
58UV protection (GO:0009650)3.16914756
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16199075
60neurofilament cytoskeleton organization (GO:0060052)3.14254603
61regulation of synaptic vesicle transport (GO:1902803)3.13967424
62adult walking behavior (GO:0007628)3.12332446
63facial nerve structural organization (GO:0021612)3.12178732
64DNA methylation involved in gamete generation (GO:0043046)3.11143540
65neuron-neuron synaptic transmission (GO:0007270)3.09636547
66regulation of neurotransmitter secretion (GO:0046928)3.06598162
67positive regulation of neurotransmitter secretion (GO:0001956)3.06466537
68mitochondrion transport along microtubule (GO:0047497)3.06144095
69establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06144095
70protein heterotetramerization (GO:0051290)3.04511277
71negative regulation of keratinocyte proliferation (GO:0010839)3.02495802
72synapse assembly (GO:0007416)3.01617248
73behavioral response to cocaine (GO:0048148)3.00415101
74regulation of postsynaptic membrane potential (GO:0060078)3.00182499
75regulation of respiratory system process (GO:0044065)2.99911173
76negative regulation of heart rate (GO:0010459)2.97436167
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96690733
78eyelid development in camera-type eye (GO:0061029)2.96475754
79cell differentiation in hindbrain (GO:0021533)2.95634821
80membrane depolarization during action potential (GO:0086010)2.95426545
81neuron recognition (GO:0008038)2.94977600
82regulation of neurotransmitter transport (GO:0051588)2.94962142
83protein neddylation (GO:0045116)2.94699110
84negative regulation of appetite (GO:0032099)2.94676826
85negative regulation of response to food (GO:0032096)2.94676826
86synaptic vesicle endocytosis (GO:0048488)2.92450352
87regulation of synaptic transmission, GABAergic (GO:0032228)2.92390872
88locomotory exploration behavior (GO:0035641)2.91043246
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.90942800
90metanephric nephron tubule development (GO:0072234)2.89373556
91metanephric tubule development (GO:0072170)2.89373556
92cranial nerve structural organization (GO:0021604)2.87847963
93regulation of respiratory gaseous exchange (GO:0043576)2.86537619
94cellular polysaccharide catabolic process (GO:0044247)2.86435204
95regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85939551
96regulation of synapse assembly (GO:0051963)2.82993262
97mechanosensory behavior (GO:0007638)2.82038628
98glutamate secretion (GO:0014047)2.82032629
99startle response (GO:0001964)2.81537579
100multicellular organismal signaling (GO:0035637)2.80389574
101cellular potassium ion homeostasis (GO:0030007)2.80191608
102regulation of neuronal synaptic plasticity (GO:0048168)2.79449878
103transmission of nerve impulse (GO:0019226)2.78498835
104central nervous system myelination (GO:0022010)2.78441681
105axon ensheathment in central nervous system (GO:0032291)2.78441681
106auditory behavior (GO:0031223)2.78097773
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77249245
108polysaccharide catabolic process (GO:0000272)2.77017668
109cranial nerve morphogenesis (GO:0021602)2.76389564
110membrane repolarization (GO:0086009)2.76312198
111regulation of membrane repolarization (GO:0060306)2.76212088
112positive regulation of synapse maturation (GO:0090129)2.76129700
113central nervous system neuron axonogenesis (GO:0021955)2.75682948
114dendrite morphogenesis (GO:0048813)2.74878748
115positive regulation of neurotransmitter transport (GO:0051590)2.74796228
116exploration behavior (GO:0035640)2.73702767
117response to auditory stimulus (GO:0010996)2.71627812
118positive regulation of calcium ion import (GO:0090280)2.70372862
119retinal ganglion cell axon guidance (GO:0031290)2.69154553
120regulation of catecholamine metabolic process (GO:0042069)2.68863380
121regulation of dopamine metabolic process (GO:0042053)2.68863380
122regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.68666601
123regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.68666601
124interkinetic nuclear migration (GO:0022027)2.68487896
125regulation of neurotransmitter uptake (GO:0051580)2.67855519
126positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67580142
127membrane depolarization (GO:0051899)2.67392196
128neuromuscular synaptic transmission (GO:0007274)2.65632140
129regulation of pigment cell differentiation (GO:0050932)2.65342270
130neurotransmitter transport (GO:0006836)2.64365600
131negative regulation of catecholamine secretion (GO:0033604)2.63836700
132spinal cord association neuron differentiation (GO:0021527)2.63713001
133negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.63612831
134central nervous system projection neuron axonogenesis (GO:0021952)2.63404208
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63401660
136gamma-aminobutyric acid transport (GO:0015812)2.62210875
137detection of calcium ion (GO:0005513)2.61099330
138membrane repolarization during action potential (GO:0086011)2.60761553
139positive regulation of meiosis (GO:0045836)2.60003241
140calcium ion import (GO:0070509)2.59630249
141behavioral defense response (GO:0002209)2.59403770
142behavioral fear response (GO:0001662)2.59403770
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.58831247
144glycerophospholipid catabolic process (GO:0046475)2.58812548
145synapse organization (GO:0050808)2.58466082
146axon extension (GO:0048675)2.58427956
147retina layer formation (GO:0010842)2.58338516
148metanephric nephron epithelium development (GO:0072243)2.56565290
149protein localization to cilium (GO:0061512)2.55428653
150neuromuscular process controlling posture (GO:0050884)2.54333355
151chemosensory behavior (GO:0007635)2.53766471
152regulation of vesicle fusion (GO:0031338)2.53627921
153phenol-containing compound biosynthetic process (GO:0046189)2.53107983
154neurotransmitter secretion (GO:0007269)2.52736032
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52028106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.90966121
2GBX2_23144817_ChIP-Seq_PC3_Human3.50285742
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.36363707
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95582813
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.94393520
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76913271
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70358527
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68648608
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60486019
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60486019
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.57811319
12TAF15_26573619_Chip-Seq_HEK293_Human2.53506226
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52667052
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48852825
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30029582
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29028546
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27403342
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27155234
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26630156
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25084330
21IGF1R_20145208_ChIP-Seq_DFB_Human2.21102094
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16084431
23REST_21632747_ChIP-Seq_MESCs_Mouse2.07809984
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.07486175
25AR_21572438_ChIP-Seq_LNCaP_Human1.97217146
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.96852551
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96804283
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89678681
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80131599
30VDR_22108803_ChIP-Seq_LS180_Human1.80076548
31* RNF2_27304074_Chip-Seq_NSC_Mouse1.77897823
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.77782221
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75181750
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73779659
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71001210
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69355391
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67885723
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66029283
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66024195
40P300_19829295_ChIP-Seq_ESCs_Human1.62820462
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57192563
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56347276
43SMAD4_21799915_ChIP-Seq_A2780_Human1.54997415
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.51371224
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51141409
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45067347
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.44778767
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44282465
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43926512
50DROSHA_22980978_ChIP-Seq_HELA_Human1.43365410
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.35009344
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35000529
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34673513
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.32654113
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.32624581
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32071483
57ER_23166858_ChIP-Seq_MCF-7_Human1.30402917
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30025534
59GATA1_22025678_ChIP-Seq_K562_Human1.29068860
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27986832
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27705837
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27705837
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26074264
64P53_22387025_ChIP-Seq_ESCs_Mouse1.25925961
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25608774
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.24679496
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22390731
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20702988
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20645053
70P300_18555785_Chip-Seq_ESCs_Mouse1.18300643
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17974413
72RUNX2_22187159_ChIP-Seq_PCA_Human1.17766043
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.17436636
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.16812471
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.16549507
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16042944
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15476369
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15470219
79AR_25329375_ChIP-Seq_VCAP_Human1.15451062
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.14969204
81FUS_26573619_Chip-Seq_HEK293_Human1.14761519
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.13295267
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13053183
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12925272
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12877192
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.12584513
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12023252
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.10988698
89STAT3_23295773_ChIP-Seq_U87_Human1.10459949
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.09945803
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.08935611
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08761246
93TCF4_23295773_ChIP-Seq_U87_Human1.07160677
94ZNF274_21170338_ChIP-Seq_K562_Hela1.06767291
95* EZH2_27294783_Chip-Seq_NPCs_Mouse1.05781181
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05287262
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.05214665
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05204294
99AR_19668381_ChIP-Seq_PC3_Human1.04646456
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04394506
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03582893
102KDM2B_26808549_Chip-Seq_REH_Human1.03255142
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01248063
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01078637
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00912344
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00300059
107CTCF_27219007_Chip-Seq_Bcells_Human1.00081115
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.97881865
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97367819
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97030926
111KLF4_18555785_Chip-Seq_ESCs_Mouse0.95861949
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.95756445
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95069068
114CTCF_18555785_Chip-Seq_ESCs_Mouse0.94743372
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93836056
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93210950
117ZFX_18555785_Chip-Seq_ESCs_Mouse0.92765033
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92645797
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.92594218
120BCAT_22108803_ChIP-Seq_LS180_Human0.92411992
121PU1_27457419_Chip-Seq_LIVER_Mouse0.92403223
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92303823
123HTT_18923047_ChIP-ChIP_STHdh_Human0.91012387
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89669833
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88766156
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88644359
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.87728645
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84644128
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82482397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.97482368
2MP0001188_hyperpigmentation5.67084123
3MP0005409_darkened_coat_color5.56786961
4MP0003880_abnormal_central_pattern4.00626797
5MP0004381_abnormal_hair_follicle3.64272334
6MP0003122_maternal_imprinting3.50142724
7MP0009379_abnormal_foot_pigmentation3.23076672
8MP0001968_abnormal_touch/_nociception3.18039411
9MP0005174_abnormal_tail_pigmentation3.00853754
10MP0004859_abnormal_synaptic_plasticity2.97822636
11MP0000015_abnormal_ear_pigmentation2.97282521
12MP0003123_paternal_imprinting2.90426766
13MP0006292_abnormal_olfactory_placode2.74782554
14MP0003121_genomic_imprinting2.45208142
15MP0003635_abnormal_synaptic_transmissio2.38291062
16MP0004270_analgesia2.29949524
17MP0005423_abnormal_somatic_nervous2.15322246
18MP0001486_abnormal_startle_reflex2.00779952
19MP0002734_abnormal_mechanical_nocicepti1.99283269
20MP0009046_muscle_twitch1.99199422
21MP0006276_abnormal_autonomic_nervous1.98953761
22* MP0009745_abnormal_behavioral_response1.95283138
23MP0008877_abnormal_DNA_methylation1.91121776
24MP0002638_abnormal_pupillary_reflex1.84726052
25MP0002064_seizures1.83754704
26MP0002272_abnormal_nervous_system1.78896140
27MP0002067_abnormal_sensory_capabilities1.71396067
28MP0002063_abnormal_learning/memory/cond1.68829476
29MP0002572_abnormal_emotion/affect_behav1.65137022
30MP0002735_abnormal_chemical_nociception1.59981493
31MP0001986_abnormal_taste_sensitivity1.59967021
32MP0004142_abnormal_muscle_tone1.55996523
33MP0002653_abnormal_ependyma_morphology1.53630504
34* MP0001970_abnormal_pain_threshold1.53305816
35MP0002733_abnormal_thermal_nociception1.43398991
36MP0002095_abnormal_skin_pigmentation1.43016951
37MP0005645_abnormal_hypothalamus_physiol1.42411488
38MP0004742_abnormal_vestibular_system1.40822908
39MP0002557_abnormal_social/conspecific_i1.40410747
40MP0000778_abnormal_nervous_system1.40151583
41MP0002736_abnormal_nociception_after1.34665134
42MP0002102_abnormal_ear_morphology1.32252759
43MP0002876_abnormal_thyroid_physiology1.28842461
44MP0002177_abnormal_outer_ear1.28777708
45MP0002184_abnormal_innervation1.27700952
46MP0000631_abnormal_neuroendocrine_gland1.25114231
47MP0005551_abnormal_eye_electrophysiolog1.25012721
48MP0002163_abnormal_gland_morphology1.21752639
49MP0001501_abnormal_sleep_pattern1.21466145
50MP0005646_abnormal_pituitary_gland1.19715035
51MP0001440_abnormal_grooming_behavior1.19374163
52MP0004133_heterotaxia1.18073284
53MP0001905_abnormal_dopamine_level1.17827905
54MP0003879_abnormal_hair_cell1.15924677
55MP0008569_lethality_at_weaning1.11125645
56MP0002882_abnormal_neuron_morphology1.00445856
57MP0008872_abnormal_physiological_respon0.98578365
58MP0004130_abnormal_muscle_cell0.98495246
59MP0002751_abnormal_autonomic_nervous0.98332810
60MP0001502_abnormal_circadian_rhythm0.97319398
61MP0000579_abnormal_nail_morphology0.96261785
62MP0006072_abnormal_retinal_apoptosis0.93733886
63MP0003890_abnormal_embryonic-extraembry0.92850568
64MP0010386_abnormal_urinary_bladder0.92512183
65MP0003283_abnormal_digestive_organ0.92325373
66MP0002277_abnormal_respiratory_mucosa0.92106898
67MP0003938_abnormal_ear_development0.91883656
68MP0005499_abnormal_olfactory_system0.89336413
69MP0005394_taste/olfaction_phenotype0.89336413
70MP0005379_endocrine/exocrine_gland_phen0.88897267
71MP0003315_abnormal_perineum_morphology0.86891702
72MP0004811_abnormal_neuron_physiology0.86853719
73MP0003631_nervous_system_phenotype0.86372766
74MP0002229_neurodegeneration0.85801649
75MP0005084_abnormal_gallbladder_morpholo0.85601118
76MP0002752_abnormal_somatic_nervous0.85100891
77MP0002909_abnormal_adrenal_gland0.84929485
78MP0004924_abnormal_behavior0.84311754
79MP0005386_behavior/neurological_phenoty0.84311754
80MP0000955_abnormal_spinal_cord0.84151796
81MP0002066_abnormal_motor_capabilities/c0.83781753
82MP0000026_abnormal_inner_ear0.83233369
83MP0002069_abnormal_eating/drinking_beha0.82653073
84MP0002837_dystrophic_cardiac_calcinosis0.82298412
85MP0002693_abnormal_pancreas_physiology0.81700903
86MP0008004_abnormal_stomach_pH0.81396654
87MP0003329_amyloid_beta_deposits0.81285885
88MP0001963_abnormal_hearing_physiology0.79933998
89MP0001984_abnormal_olfaction0.79533916
90MP0003724_increased_susceptibility_to0.79181765
91* MP0003861_abnormal_nervous_system0.78988584
92* MP0005464_abnormal_platelet_physiology0.78273903
93MP0000230_abnormal_systemic_arterial0.77422538
94MP0001529_abnormal_vocalization0.77015053
95MP0000569_abnormal_digit_pigmentation0.76687490
96MP0000566_synostosis0.76319491
97MP0005187_abnormal_penis_morphology0.76252165
98MP0005448_abnormal_energy_balance0.76195275
99MP0000681_abnormal_thyroid_gland0.75454497
100MP0005535_abnormal_body_temperature0.74633096
101MP0001664_abnormal_digestion0.73667437
102MP0005195_abnormal_posterior_eye0.72749748
103MP0003942_abnormal_urinary_system0.69826532
104MP0004085_abnormal_heartbeat0.69131296
105MP0001346_abnormal_lacrimal_gland0.68479695
106MP0005253_abnormal_eye_physiology0.68445008
107MP0001944_abnormal_pancreas_morphology0.68181649
108MP0009780_abnormal_chondrocyte_physiolo0.68097040
109MP0003119_abnormal_digestive_system0.67535278
110MP0001299_abnormal_eye_distance/0.67376453
111MP0005377_hearing/vestibular/ear_phenot0.65180569
112MP0008260_abnormal_autophagy0.64673382
113MP0005595_abnormal_vascular_smooth0.64207909
114MP0000920_abnormal_myelination0.63571182
115MP0003787_abnormal_imprinting0.62376536
116MP0004885_abnormal_endolymph0.62343634
117MP0001340_abnormal_eyelid_morphology0.61848515
118MP0003633_abnormal_nervous_system0.60612618
119* MP0002152_abnormal_brain_morphology0.59998402
120MP0000049_abnormal_middle_ear0.59347783
121MP0004145_abnormal_muscle_electrophysio0.58999414
122MP0003011_delayed_dark_adaptation0.57925615
123MP0002160_abnormal_reproductive_system0.57134280
124MP0001177_atelectasis0.57102501
125MP0000613_abnormal_salivary_gland0.56744401
126MP0004484_altered_response_of0.54773521
127MP0003868_abnormal_feces_composition0.52746263
128MP0005171_absent_coat_pigmentation0.52652414
129MP0001485_abnormal_pinna_reflex0.52454072
130MP0002822_catalepsy0.52395376

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)6.17781082
2Sex reversal (HP:0012245)6.17781082
3Abnormality of the axillary hair (HP:0100134)5.70969504
4Abnormality of secondary sexual hair (HP:0009888)5.70969504
5Focal motor seizures (HP:0011153)5.20039098
6Obstructive sleep apnea (HP:0002870)4.71162946
7Bile duct proliferation (HP:0001408)4.01228031
8Abnormal biliary tract physiology (HP:0012439)4.01228031
9Myokymia (HP:0002411)3.58178318
10Febrile seizures (HP:0002373)3.52894661
11Split foot (HP:0001839)3.48950575
12Hypothermia (HP:0002045)3.41346891
13Hepatoblastoma (HP:0002884)3.29939768
14Sleep apnea (HP:0010535)3.29165314
15Absent speech (HP:0001344)3.26171606
16Fetal akinesia sequence (HP:0001989)3.24404348
17Attenuation of retinal blood vessels (HP:0007843)3.23006061
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.07948422
19Focal seizures (HP:0007359)3.04513573
20Optic nerve hypoplasia (HP:0000609)3.03609465
21Broad-based gait (HP:0002136)3.02507481
22Optic disc pallor (HP:0000543)2.95610082
23Gaze-evoked nystagmus (HP:0000640)2.94588375
24Testicular neoplasm (HP:0010788)2.94059559
25Progressive cerebellar ataxia (HP:0002073)2.91434095
26Thyroid-stimulating hormone excess (HP:0002925)2.86130200
27Abnormality of the corticospinal tract (HP:0002492)2.85560506
28Prolonged bleeding time (HP:0003010)2.83271933
29Iris hypopigmentation (HP:0007730)2.78655906
30Menorrhagia (HP:0000132)2.75328918
31Epileptic encephalopathy (HP:0200134)2.72577513
32Impaired vibration sensation in the lower limbs (HP:0002166)2.71721055
33Abnormality of the labia minora (HP:0012880)2.70141721
34Alacrima (HP:0000522)2.69921111
35Ocular albinism (HP:0001107)2.67857340
36Gait imbalance (HP:0002141)2.67244901
37Gonadal dysgenesis (HP:0000133)2.65986322
38Torticollis (HP:0000473)2.65340376
39Epileptiform EEG discharges (HP:0011182)2.65027242
40Spastic tetraplegia (HP:0002510)2.62524889
41Esotropia (HP:0000565)2.60047682
42Atonic seizures (HP:0010819)2.59361526
43Visual hallucinations (HP:0002367)2.58175351
44Limb dystonia (HP:0002451)2.57579789
45Abnormal pancreas size (HP:0012094)2.56199540
46Focal dystonia (HP:0004373)2.56110647
47EEG with generalized epileptiform discharges (HP:0011198)2.53358526
48Growth hormone deficiency (HP:0000824)2.52663436
49Nonprogressive disorder (HP:0003680)2.51586873
50Urinary bladder sphincter dysfunction (HP:0002839)2.51227762
51Hypsarrhythmia (HP:0002521)2.49734170
52Agitation (HP:0000713)2.45316290
53Nephronophthisis (HP:0000090)2.45002847
54Medial flaring of the eyebrow (HP:0010747)2.44994843
55Pachygyria (HP:0001302)2.42356201
56Abnormality of calcium-phosphate metabolism (HP:0100530)2.42018881
57Scanning speech (HP:0002168)2.41956662
58Action tremor (HP:0002345)2.41001975
59Septo-optic dysplasia (HP:0100842)2.40125130
60Pancreatic fibrosis (HP:0100732)2.39136988
61Diplopia (HP:0000651)2.39051123
62Abnormality of binocular vision (HP:0011514)2.39051123
63Absent septum pellucidum (HP:0001331)2.38726554
64Abnormal rod and cone electroretinograms (HP:0008323)2.37298289
65Supranuclear gaze palsy (HP:0000605)2.36973099
66Poor suck (HP:0002033)2.36834772
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36323836
68Bradycardia (HP:0001662)2.34113230
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.32999463
70Absent/shortened dynein arms (HP:0200106)2.32999463
71Abnormality of the septum pellucidum (HP:0007375)2.27305726
72Increased mean platelet volume (HP:0011877)2.27219224
73Generalized tonic-clonic seizures (HP:0002069)2.26889224
74Abnormal ciliary motility (HP:0012262)2.26108944
75Failure to thrive in infancy (HP:0001531)2.24927956
76Dialeptic seizures (HP:0011146)2.24286646
77Decreased lacrimation (HP:0000633)2.22872644
78Short tibia (HP:0005736)2.22107198
79Neoplasm of the adrenal cortex (HP:0100641)2.21730515
80Craniofacial dystonia (HP:0012179)2.21427383
81Absence seizures (HP:0002121)2.20336510
82Type I transferrin isoform profile (HP:0003642)2.19884834
83Decreased central vision (HP:0007663)2.15397614
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.15104486
85Spastic gait (HP:0002064)2.14863153
86Agammaglobulinemia (HP:0004432)2.14280388
87Lissencephaly (HP:0001339)2.13287429
88Abnormality of magnesium homeostasis (HP:0004921)2.11817681
89Germ cell neoplasia (HP:0100728)2.11228166
90Purpura (HP:0000979)2.10245575
91Male pseudohermaphroditism (HP:0000037)2.10121365
92Morphological abnormality of the pyramidal tract (HP:0002062)2.09586890
93Mutism (HP:0002300)2.08447629
94Severe visual impairment (HP:0001141)2.07962825
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07262675
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.06982590
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06982590
98Ankle clonus (HP:0011448)2.06551123
99Status epilepticus (HP:0002133)2.04070904
100Oligodactyly (hands) (HP:0001180)2.03864747
101Molar tooth sign on MRI (HP:0002419)2.03814824
102Abnormality of midbrain morphology (HP:0002418)2.03814824
103Concave nail (HP:0001598)2.03114155
104Adrenal hypoplasia (HP:0000835)2.02657027
105Retinal dysplasia (HP:0007973)2.01940089
106Dysmetria (HP:0001310)1.99863510
107Congenital malformation of the right heart (HP:0011723)1.99027842
108Double outlet right ventricle (HP:0001719)1.99027842
109Congenital primary aphakia (HP:0007707)1.98362037
110Progressive inability to walk (HP:0002505)1.97450013
111Specific learning disability (HP:0001328)1.96753216
112Increased hepatocellular lipid droplets (HP:0006565)1.96119494
113Hypogonadotrophic hypogonadism (HP:0000044)1.95363844
114Petechiae (HP:0000967)1.95201737
115Anxiety (HP:0000739)1.94947324
116Abnormality of the renal medulla (HP:0100957)1.94896039
117Vaginal atresia (HP:0000148)1.94772922
118Abnormal platelet volume (HP:0011876)1.94565764
119Restlessness (HP:0000711)1.93993545
120Drooling (HP:0002307)1.93833343
121Excessive salivation (HP:0003781)1.93833343
122Abnormal respiratory epithelium morphology (HP:0012253)1.92747683
123Abnormal respiratory motile cilium morphology (HP:0005938)1.92747683
124Pancreatic cysts (HP:0001737)1.92610655
125Genital tract atresia (HP:0001827)1.92315124
126Decreased circulating renin level (HP:0003351)1.91501472
127Dysdiadochokinesis (HP:0002075)1.90622861
128Abnormal respiratory motile cilium physiology (HP:0012261)1.90565504
129Akinesia (HP:0002304)1.90203205
130Nephrogenic diabetes insipidus (HP:0009806)1.87584637
131Hemiparesis (HP:0001269)1.87554844
132Enlarged penis (HP:0000040)1.86071343
133Genetic anticipation (HP:0003743)1.86001963
134Intention tremor (HP:0002080)1.84415060
135Anosmia (HP:0000458)1.84016798
136Abnormal eating behavior (HP:0100738)1.83795639
137Urinary urgency (HP:0000012)1.83159724
138Prolonged QT interval (HP:0001657)1.81145615
139Ventricular fibrillation (HP:0001663)1.80338706
140Aplasia/hypoplasia of the uterus (HP:0008684)1.80327553
141Generalized hypotonia (HP:0001290)1.79409531
142Papilledema (HP:0001085)1.79254052
143Labial hypoplasia (HP:0000066)1.78981020
144Cutaneous finger syndactyly (HP:0010554)1.78707245
145Renal Fanconi syndrome (HP:0001994)1.77826971
146Hypoplasia of the corpus callosum (HP:0002079)1.76755412
147Laryngomalacia (HP:0001601)1.76235422
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75802231
149Hypomagnesemia (HP:0002917)1.75673057
150Abnormality of dental color (HP:0011073)1.74697951
151Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74033146
152Cortical visual impairment (HP:0100704)1.72631358
153Poor eye contact (HP:0000817)1.72069144
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71694649
155Inability to walk (HP:0002540)1.71467677
156Abnormal hair whorl (HP:0010721)1.71218586
157Hyperthyroidism (HP:0000836)1.70801368
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70290971
159Hypoplasia of the brainstem (HP:0002365)1.70290971
160Cystic liver disease (HP:0006706)1.70288352
161Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69387902
162Amblyopia (HP:0000646)1.68753105
163Joint hemorrhage (HP:0005261)1.68042296
164Median cleft lip (HP:0000161)1.65896418
165True hermaphroditism (HP:0010459)1.65773643
166Depression (HP:0000716)1.65197024
167Hyperventilation (HP:0002883)1.65064481
168Polyphagia (HP:0002591)1.64647096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.41662255
2MKNK23.53481383
3PHKG13.45036087
4PHKG23.45036087
5TNIK3.33360459
6NTRK32.40232304
7FRK2.16452758
8MUSK2.05240279
9MARK12.04863978
10TLK12.03500912
11PAK31.90231232
12MAP2K71.88210998
13FES1.80766603
14MKNK11.55607591
15MAP3K11.54410811
16INSRR1.53982366
17SGK4941.52502254
18UHMK11.46600953
19EPHA41.41898679
20PRKD31.41613873
21CDK191.41071665
22CAMK1G1.34229427
23MAPK131.32686775
24PRPF4B1.32006520
25SGK21.30081611
26MAP3K121.28629081
27TYRO31.26536010
28MINK11.15058586
29DAPK21.13950271
30PRKD21.10587341
31STK160.99689397
32PRKCH0.98258594
33EPHB20.98222348
34FGFR20.97818777
35RIPK40.97481396
36CAMKK20.97410258
37CLK10.95821754
38DYRK1A0.95425193
39GRK50.95416454
40NTRK20.92314775
41PKN10.91455058
42SGK30.90994520
43STK380.89679935
44GRK70.89039864
45CDK50.85235292
46CAMK10.85003110
47MAP3K110.84756915
48CAMK2B0.84087381
49MAP3K40.83782720
50SRPK10.82548683
51CAMK2A0.81998722
52CAMK1D0.81323340
53MAPK150.80901418
54IRAK20.79961064
55MAP2K40.78703301
56MAP3K90.78304251
57NLK0.77900002
58BLK0.76981996
59PRKCZ0.75865077
60BMPR20.75642493
61ADRBK20.74335100
62HIPK20.73982234
63MAP4K20.72939078
64STK110.71808559
65DYRK1B0.69507877
66PIK3CG0.68193394
67NTRK10.67266934
68SGK10.67085734
69CDK140.66790807
70DYRK20.66625745
71FER0.64845227
72CSNK1G10.64069733
73TAOK30.63493498
74YES10.63392306
75PNCK0.63359938
76BMX0.62584012
77PINK10.62316772
78BCR0.61609160
79OXSR10.61133790
80NME10.59379488
81IRAK10.58723617
82CSNK1E0.57616929
83CDK30.56732577
84ERBB20.56374510
85MAP3K130.55958467
86PRKG10.55894029
87CSNK1G20.55871315
88CDK150.54438133
89PRKCG0.53699118
90WNK30.52804448
91CDK180.52724338
92EIF2AK20.51946694
93CAMKK10.51596120
94TNK20.50499733
95GRK10.48691270
96CAMK2D0.48564598
97CAMK2G0.48292096
98ARAF0.47779034
99PAK60.47321185
100FGR0.47198822
101NEK60.46817585
102PRKCE0.46421209
103CDK11A0.45940406
104STK390.45329302
105PRKAA20.44186027
106BMPR1B0.44009552
107CSNK1G30.43968622
108MAPKAPK50.43881545
109RPS6KA30.43180779
110DYRK30.42779475
111KSR10.40780012
112SIK20.40741878
113MAP3K20.40594462
114CSNK1A10.39909955
115LIMK10.39609579
116* PRKCA0.39406360
117MARK20.39405661
118PRKCI0.39086138
119PLK20.38723559
120STK30.38605777
121PTK2B0.37664994
122MAPK100.36327435
123RPS6KA20.36122850
124PRKACG0.35420031
125CSNK1D0.34389669
126WNK40.34351097
127PRKACA0.34180605
128MAPK120.34172105
129PRKCQ0.33825549
130FYN0.33572571
131EIF2AK30.32743118
132ILK0.32717082
133DAPK30.32036639
134IRAK40.31174507
135ADRBK10.30695038
136IRAK30.30050269
137CSNK1A1L0.30028335
138BRAF0.28553183
139DAPK10.28293605
140SGK2230.27741535

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.54209642
2Phototransduction_Homo sapiens_hsa047443.34117033
3Protein export_Homo sapiens_hsa030602.46515945
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39970361
5Glutamatergic synapse_Homo sapiens_hsa047242.34930963
6Morphine addiction_Homo sapiens_hsa050322.32887792
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.30919994
8GABAergic synapse_Homo sapiens_hsa047272.26762127
9Taste transduction_Homo sapiens_hsa047422.15315884
10Circadian entrainment_Homo sapiens_hsa047132.12984294
11Olfactory transduction_Homo sapiens_hsa047402.12028465
12Synaptic vesicle cycle_Homo sapiens_hsa047212.10272360
13Serotonergic synapse_Homo sapiens_hsa047262.03294789
14Insulin secretion_Homo sapiens_hsa049111.98529982
15Amphetamine addiction_Homo sapiens_hsa050311.91069815
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90896574
17Long-term potentiation_Homo sapiens_hsa047201.79540336
18Salivary secretion_Homo sapiens_hsa049701.75481105
19Dopaminergic synapse_Homo sapiens_hsa047281.69820255
20Cholinergic synapse_Homo sapiens_hsa047251.69345716
21Calcium signaling pathway_Homo sapiens_hsa040201.66687517
22Cocaine addiction_Homo sapiens_hsa050301.66268421
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66045188
24Oxidative phosphorylation_Homo sapiens_hsa001901.63777613
25Melanogenesis_Homo sapiens_hsa049161.55634410
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52854088
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52070347
28* Long-term depression_Homo sapiens_hsa047301.50447982
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50378050
30Renin secretion_Homo sapiens_hsa049241.43244379
31GnRH signaling pathway_Homo sapiens_hsa049121.39038077
32Axon guidance_Homo sapiens_hsa043601.34168695
33Ribosome_Homo sapiens_hsa030101.27992187
34Alzheimers disease_Homo sapiens_hsa050101.26832626
35Gastric acid secretion_Homo sapiens_hsa049711.18019326
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16682841
37Vibrio cholerae infection_Homo sapiens_hsa051101.13844942
38Parkinsons disease_Homo sapiens_hsa050121.11635323
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11325160
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11037009
41Cardiac muscle contraction_Homo sapiens_hsa042601.07793749
42Oxytocin signaling pathway_Homo sapiens_hsa049211.07446984
43Gap junction_Homo sapiens_hsa045401.06792216
44cAMP signaling pathway_Homo sapiens_hsa040241.06024765
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05077483
46Collecting duct acid secretion_Homo sapiens_hsa049661.02974994
47Sphingolipid metabolism_Homo sapiens_hsa006000.97307992
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97005369
49Nitrogen metabolism_Homo sapiens_hsa009100.95937287
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95518441
51Ether lipid metabolism_Homo sapiens_hsa005650.94967059
52Butanoate metabolism_Homo sapiens_hsa006500.94598549
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94404250
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93567270
55Platelet activation_Homo sapiens_hsa046110.92396882
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91206655
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89264071
58Circadian rhythm_Homo sapiens_hsa047100.88445923
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87395522
60Steroid biosynthesis_Homo sapiens_hsa001000.86864143
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86477978
62Huntingtons disease_Homo sapiens_hsa050160.85788638
63Dorso-ventral axis formation_Homo sapiens_hsa043200.85778852
64Linoleic acid metabolism_Homo sapiens_hsa005910.82472431
65ErbB signaling pathway_Homo sapiens_hsa040120.82006252
66Fanconi anemia pathway_Homo sapiens_hsa034600.80172453
67Rap1 signaling pathway_Homo sapiens_hsa040150.76382652
68Glucagon signaling pathway_Homo sapiens_hsa049220.76020594
69Pancreatic secretion_Homo sapiens_hsa049720.75975526
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.75959758
71Wnt signaling pathway_Homo sapiens_hsa043100.75239408
72Alcoholism_Homo sapiens_hsa050340.74097839
73Type I diabetes mellitus_Homo sapiens_hsa049400.73633012
74Ras signaling pathway_Homo sapiens_hsa040140.71651008
75Vitamin B6 metabolism_Homo sapiens_hsa007500.71554823
76Hedgehog signaling pathway_Homo sapiens_hsa043400.68343226
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67587076
78Type II diabetes mellitus_Homo sapiens_hsa049300.66777230
79Bile secretion_Homo sapiens_hsa049760.65496702
80Other glycan degradation_Homo sapiens_hsa005110.64137132
81MAPK signaling pathway_Homo sapiens_hsa040100.63721799
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62961534
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61568178
84Dilated cardiomyopathy_Homo sapiens_hsa054140.61127937
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60901393
86Estrogen signaling pathway_Homo sapiens_hsa049150.58554427
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58005330
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56596621
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.54905472
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54249596
91Ovarian steroidogenesis_Homo sapiens_hsa049130.52929490
92Choline metabolism in cancer_Homo sapiens_hsa052310.51612216
93Hippo signaling pathway_Homo sapiens_hsa043900.50887538
94beta-Alanine metabolism_Homo sapiens_hsa004100.50296425
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49826140
96Glycerolipid metabolism_Homo sapiens_hsa005610.49271434
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47453898
98Basal cell carcinoma_Homo sapiens_hsa052170.44661975
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43392003
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.42341030
101Thyroid hormone synthesis_Homo sapiens_hsa049180.41885002
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41386842
103Oocyte meiosis_Homo sapiens_hsa041140.41071290
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.39356333
105Arachidonic acid metabolism_Homo sapiens_hsa005900.39302309
106Endocytosis_Homo sapiens_hsa041440.39169544
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38130181
108Regulation of autophagy_Homo sapiens_hsa041400.37200266
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36098181
110Insulin signaling pathway_Homo sapiens_hsa049100.36073283
111Glioma_Homo sapiens_hsa052140.35132999
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34980950
113Rheumatoid arthritis_Homo sapiens_hsa053230.34202276
114African trypanosomiasis_Homo sapiens_hsa051430.33362494
115VEGF signaling pathway_Homo sapiens_hsa043700.32336809
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32195733
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.30133050
118Prion diseases_Homo sapiens_hsa050200.29498898
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29154005
120Fatty acid elongation_Homo sapiens_hsa000620.27887271
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27078195
122Renal cell carcinoma_Homo sapiens_hsa052110.26465953
123Chemokine signaling pathway_Homo sapiens_hsa040620.23771966
124Graft-versus-host disease_Homo sapiens_hsa053320.22976917
125Melanoma_Homo sapiens_hsa052180.21326562

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