GNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of rhodopsin mediated signaling pathway (GO:0022400)8.60502924
2* rhodopsin mediated signaling pathway (GO:0016056)8.22734614
3retinal cone cell development (GO:0046549)6.63510756
4photoreceptor cell development (GO:0042461)6.30612413
5eye photoreceptor cell development (GO:0042462)6.05297850
6photoreceptor cell maintenance (GO:0045494)5.76394749
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.16251257
8detection of light stimulus involved in sensory perception (GO:0050962)5.15857540
9detection of light stimulus involved in visual perception (GO:0050908)5.15857540
10GMP metabolic process (GO:0046037)5.07951811
11retinal rod cell development (GO:0046548)4.83101049
12negative regulation of dendrite morphogenesis (GO:0050774)4.77612334
13* phototransduction (GO:0007602)4.54790980
14neuron cell-cell adhesion (GO:0007158)4.45029131
15* detection of light stimulus (GO:0009583)4.43368483
16positive regulation of guanylate cyclase activity (GO:0031284)4.38989987
17* detection of visible light (GO:0009584)4.37255155
18* phototransduction, visible light (GO:0007603)4.36515144
19sodium ion export (GO:0071436)4.30589855
20protein localization to endosome (GO:0036010)4.18530828
21protein localization to synapse (GO:0035418)4.17826315
22cytoskeletal anchoring at plasma membrane (GO:0007016)4.15351943
23regulation of NFAT protein import into nucleus (GO:0051532)4.12966754
24regulation of synaptic vesicle exocytosis (GO:2000300)4.11211491
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07429885
26visual perception (GO:0007601)4.02199403
27sensory perception of light stimulus (GO:0050953)3.97762181
28cellular potassium ion homeostasis (GO:0030007)3.95177632
29nonmotile primary cilium assembly (GO:0035058)3.94984631
30regulation of guanylate cyclase activity (GO:0031282)3.93372425
31regulation of early endosome to late endosome transport (GO:2000641)3.91125074
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90109990
33glutamate secretion (GO:0014047)3.89359493
34inositol phosphate catabolic process (GO:0071545)3.87040765
35layer formation in cerebral cortex (GO:0021819)3.85628399
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73732081
37synaptic vesicle exocytosis (GO:0016079)3.68273325
38presynaptic membrane assembly (GO:0097105)3.65437898
39vocalization behavior (GO:0071625)3.65355603
40cerebellar granule cell differentiation (GO:0021707)3.65126867
41photoreceptor cell differentiation (GO:0046530)3.63127743
42eye photoreceptor cell differentiation (GO:0001754)3.63127743
43postsynaptic membrane organization (GO:0001941)3.61677650
44protein localization to cilium (GO:0061512)3.59289325
45neurotransmitter-gated ion channel clustering (GO:0072578)3.58700244
46regulation of synaptic vesicle transport (GO:1902803)3.57779737
47regulation of ARF protein signal transduction (GO:0032012)3.55354667
48negative regulation of dendrite development (GO:2000171)3.51135014
49pyrimidine nucleobase catabolic process (GO:0006208)3.49921516
50sensory perception of smell (GO:0007608)3.48934968
51synaptic vesicle maturation (GO:0016188)3.44696574
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40489415
53* detection of external stimulus (GO:0009581)3.31694942
54mating behavior (GO:0007617)3.29673738
55positive regulation of neurotransmitter transport (GO:0051590)3.29344615
56protein-chromophore linkage (GO:0018298)3.28901727
57locomotory exploration behavior (GO:0035641)3.28895621
58* detection of abiotic stimulus (GO:0009582)3.28269844
59axoneme assembly (GO:0035082)3.24662339
60phosphorelay signal transduction system (GO:0000160)3.20986240
61melanosome transport (GO:0032402)3.20480663
62regulation of neurotransmitter secretion (GO:0046928)3.18804830
63protein retention in ER lumen (GO:0006621)3.17657502
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16173534
65mitochondrion transport along microtubule (GO:0047497)3.16173534
66presynaptic membrane organization (GO:0097090)3.14898119
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.13293459
68establishment of melanosome localization (GO:0032401)3.12370608
69neuromuscular process controlling balance (GO:0050885)3.11849940
70establishment of mitochondrion localization (GO:0051654)3.10335514
71neurofilament cytoskeleton organization (GO:0060052)3.08677301
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08109952
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06797464
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05808807
75melanosome localization (GO:0032400)3.05150054
76regulation of neuronal synaptic plasticity (GO:0048168)3.04891096
77pigment granule transport (GO:0051904)3.04710301
78amino acid import (GO:0043090)3.04476935
79* cellular response to light stimulus (GO:0071482)3.03430406
80cell migration in hindbrain (GO:0021535)3.02487562
81regulation of glycogen (starch) synthase activity (GO:2000465)3.01781566
82regulation of voltage-gated calcium channel activity (GO:1901385)2.98752573
83negative regulation of erythrocyte differentiation (GO:0045647)2.98387022
84* retina development in camera-type eye (GO:0060041)2.97922522
85establishment of pigment granule localization (GO:0051905)2.97685720
86cell-cell junction maintenance (GO:0045217)2.97645009
87adherens junction assembly (GO:0034333)2.97268157
88stress fiber assembly (GO:0043149)2.95466178
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95071209
90phosphorylated carbohydrate dephosphorylation (GO:0046838)2.94826961
91inositol phosphate dephosphorylation (GO:0046855)2.94826961
92cell communication by electrical coupling (GO:0010644)2.94592132
93neurotransmitter secretion (GO:0007269)2.93803476
94positive regulation of synapse maturation (GO:0090129)2.93528222
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93011525
96neuronal action potential (GO:0019228)2.92570626
97pigment granule localization (GO:0051875)2.91989763
98behavioral response to cocaine (GO:0048148)2.90580569
99cortical actin cytoskeleton organization (GO:0030866)2.89209061
100L-amino acid import (GO:0043092)2.88713021
101sympathetic nervous system development (GO:0048485)2.88394296
102positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.87422441
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86547343
104barbed-end actin filament capping (GO:0051016)2.85830553
105startle response (GO:0001964)2.84115453
106regulation of glutamate receptor signaling pathway (GO:1900449)2.83982790
107neuron recognition (GO:0008038)2.83203881
108protein polyglutamylation (GO:0018095)2.81920079
109semaphorin-plexin signaling pathway (GO:0071526)2.80477910
110regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.79640408
111positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.79640408
112spinal cord development (GO:0021510)2.79325294
113positive regulation of neurotransmitter secretion (GO:0001956)2.78549501
114regulation of cGMP metabolic process (GO:0030823)2.77892686
115membrane hyperpolarization (GO:0060081)2.77344356
116intraciliary transport (GO:0042073)2.76791794
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76429191
118negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76373468
119regulation of synapse maturation (GO:0090128)2.76224266
120cell-substrate adherens junction assembly (GO:0007045)2.74779090
121focal adhesion assembly (GO:0048041)2.74779090
122positive regulation of membrane potential (GO:0045838)2.74574002
123retina layer formation (GO:0010842)2.74309057
124axonal fasciculation (GO:0007413)2.73542815
125hippocampus development (GO:0021766)2.71923572
126regulation of female receptivity (GO:0045924)2.71261420
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71006693
128regulation of neurotransmitter transport (GO:0051588)2.70543002
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69693700
130synaptic vesicle endocytosis (GO:0048488)2.69253445
131ER overload response (GO:0006983)2.69050948
132skin morphogenesis (GO:0043589)2.68552543
133neuronal ion channel clustering (GO:0045161)2.67894406
134detection of calcium ion (GO:0005513)2.67587777
135response to parathyroid hormone (GO:0071107)2.66790487
136activation of Rac GTPase activity (GO:0032863)2.66071580
137Golgi transport vesicle coating (GO:0048200)2.65744450
138COPI coating of Golgi vesicle (GO:0048205)2.65744450
139negative regulation of microtubule polymerization (GO:0031115)2.65239901
140negative regulation of catenin import into nucleus (GO:0035414)2.65059296
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64966308
142activation of protein kinase A activity (GO:0034199)2.64104397
143axon extension (GO:0048675)2.62268479
144signal complex assembly (GO:0007172)2.58000411
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57887879
146protein targeting to plasma membrane (GO:0072661)2.57270777
147cortical cytoskeleton organization (GO:0030865)2.55656996
148regulation of glucose import in response to insulin stimulus (GO:2001273)2.54062457
149regulation of synaptic plasticity (GO:0048167)2.51411690
150cell-substrate junction assembly (GO:0007044)2.51008057
151glucocorticoid receptor signaling pathway (GO:0042921)2.50524144
152neuron projection extension (GO:1990138)2.50290759
153exploration behavior (GO:0035640)2.50062701
154cerebellar Purkinje cell layer development (GO:0021680)2.46215013
155clathrin coat assembly (GO:0048268)2.44873339
156camera-type eye morphogenesis (GO:0048593)2.44560410
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.40551471
158potassium ion homeostasis (GO:0055075)2.40496823
159* G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.36582512
160ionotropic glutamate receptor signaling pathway (GO:0035235)2.36342676
161positive regulation of protein dephosphorylation (GO:0035307)2.35747693
162positive regulation of axon extension (GO:0045773)2.35378964
163* dopamine receptor signaling pathway (GO:0007212)2.32007040
164actin filament bundle organization (GO:0061572)2.31235853
165actin filament bundle assembly (GO:0051017)2.31235853
166positive regulation of receptor recycling (GO:0001921)2.30395940
167regulation of ARF GTPase activity (GO:0032312)2.26783732
168activation of MAPKKK activity (GO:0000185)2.23992332
169positive regulation of Rap GTPase activity (GO:0032854)2.23178086
170negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23085901
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23060172
172regulation of mammary gland epithelial cell proliferation (GO:0033599)2.22644300
173negative regulation of fatty acid transport (GO:2000192)2.21767707
174peptidyl-threonine modification (GO:0018210)2.21397977
175maternal placenta development (GO:0001893)2.21232605
176vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.20841447
177developmental cell growth (GO:0048588)2.18718052
178peptidyl-threonine phosphorylation (GO:0018107)2.18593906
179regulation of protein dephosphorylation (GO:0035304)2.15774340
180positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14083549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86289893
2GBX2_23144817_ChIP-Seq_PC3_Human4.08345312
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.10155982
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08151380
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.93881829
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.84203750
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.64662273
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63448367
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53744418
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.51792231
11* KDM2B_26808549_Chip-Seq_K562_Human2.50952073
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.41677248
13* LXR_22292898_ChIP-Seq_THP-1_Human2.39680898
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27988186
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25507233
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20597670
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20597670
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.17146115
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16231241
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.15677134
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.14670224
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14658992
23TAF15_26573619_Chip-Seq_HEK293_Human2.13949565
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.13828436
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13715816
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12064665
27* KDM2B_26808549_Chip-Seq_DND41_Human2.09857646
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08853760
29REST_21632747_ChIP-Seq_MESCs_Mouse2.06267412
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04722021
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04158519
32TCF7_22412390_ChIP-Seq_EML_Mouse1.97568248
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95888485
34* MYC_22102868_ChIP-Seq_BL_Human1.95537774
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94626953
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94290919
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93634950
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.93154913
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91807210
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91689737
41CLOCK_20551151_ChIP-Seq_293T_Human1.90544861
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89941309
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.89655367
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88429714
45P300_19829295_ChIP-Seq_ESCs_Human1.86094903
46SMAD4_21799915_ChIP-Seq_A2780_Human1.84888672
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84453968
48* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83883968
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83746189
50RNF2_27304074_Chip-Seq_NSC_Mouse1.82333642
51* REST_18959480_ChIP-ChIP_MESCs_Mouse1.82076552
52* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81590173
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80572744
54VDR_21846776_ChIP-Seq_THP-1_Human1.80045520
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.79458133
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.77089919
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.77072711
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.76967363
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76851813
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76229828
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74154091
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73445272
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72150694
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71707545
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71396516
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.70061383
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66626957
68AHR_22903824_ChIP-Seq_MCF-7_Human1.65999096
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.65167742
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63792108
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63337865
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63106359
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61690301
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.60857667
75DROSHA_22980978_ChIP-Seq_HELA_Human1.60498170
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.59171875
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57717570
78VDR_22108803_ChIP-Seq_LS180_Human1.56342836
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56221066
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55958547
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.55447551
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.53210524
83* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52675292
84* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51101561
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50953405
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50429996
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47879534
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47552122
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46101648
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42588924
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41616814
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.39973922
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.39655015
94STAT3_23295773_ChIP-Seq_U87_Human1.38379948
95AR_21572438_ChIP-Seq_LNCaP_Human1.37356367
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36247861
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36097141
98* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35813766
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34029642
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32097128
101IGF1R_20145208_ChIP-Seq_DFB_Human1.31222283
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30116184
103* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29771894
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29472917
105* CREB1_26743006_Chip-Seq_LNCaP_Human1.28858199
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26825129
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25543833
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25248844
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.24779295
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23912336
111RUNX2_22187159_ChIP-Seq_PCA_Human1.23226388
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22552904
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22286528
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20791350
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.20038450
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19836365
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19836365
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19377306
119TCF4_23295773_ChIP-Seq_U87_Human1.18585960
120* AR_19668381_ChIP-Seq_PC3_Human1.18538189
121TET1_21490601_ChIP-Seq_MESCs_Mouse1.18385081
122AR_25329375_ChIP-Seq_VCAP_Human1.18139815
123* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18115427
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18099282
125* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17342569
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16766052
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.16569230
128SMC4_20622854_ChIP-Seq_HELA_Human1.16142408
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16133779
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15272817
131TET1_21451524_ChIP-Seq_MESCs_Mouse1.12704825
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11997036
133ER_23166858_ChIP-Seq_MCF-7_Human1.11682037
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10663920
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10613200
136ZNF263_19887448_ChIP-Seq_K562_Human1.09647578
137* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09432512
138RING1B_27294783_Chip-Seq_NPCs_Mouse1.08953033
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08865373
140JUN_21703547_ChIP-Seq_K562_Human1.08243794
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07968619
142* SOX9_26525672_Chip-Seq_HEART_Mouse1.07831105
143* CTCF_27219007_Chip-Seq_Bcells_Human1.06895758
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06448557
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05734056
146VDR_24763502_ChIP-Seq_THP-1_Human1.05141489
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04623618
148SMAD3_21741376_ChIP-Seq_ESCs_Human1.03340072
149TP53_22127205_ChIP-Seq_IMR90_Human1.02902936
150* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02085451
151TP53_20018659_ChIP-ChIP_R1E_Mouse1.01397102
152CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01326210
153* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01306755
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01160114
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.00841718
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00349172
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00060994
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98981894
159NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97903947
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97713904
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96370556
162KDM2B_26808549_Chip-Seq_REH_Human0.96049307
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95914226
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95585865
165SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95267601
166E2F1_18555785_Chip-Seq_ESCs_Mouse0.94996775
167RING1B_27294783_Chip-Seq_ESCs_Mouse0.92498878
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92041357
169TP53_18474530_ChIP-ChIP_U2OS_Human0.91742234
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91118694
171CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91040103
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90809431
173P53_22387025_ChIP-Seq_ESCs_Mouse0.89542255
174BCAT_22108803_ChIP-Seq_LS180_Human0.89321780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.11410580
2MP0003705_abnormal_hypodermis_morpholog4.77519306
3MP0001984_abnormal_olfaction3.70064153
4MP0003011_delayed_dark_adaptation3.60976782
5MP0005253_abnormal_eye_physiology3.35492643
6MP0008789_abnormal_olfactory_epithelium3.14563431
7MP0005409_darkened_coat_color3.12204398
8MP0004270_analgesia3.11031778
9MP0005394_taste/olfaction_phenotype3.06993697
10MP0005499_abnormal_olfactory_system3.06993697
11MP0003329_amyloid_beta_deposits2.97649787
12MP0006072_abnormal_retinal_apoptosis2.96966534
13MP0003880_abnormal_central_pattern2.73557139
14MP0008438_abnormal_cutaneous_collagen2.61323448
15MP0004859_abnormal_synaptic_plasticity2.57653380
16MP0002734_abnormal_mechanical_nocicepti2.57518361
17MP0002877_abnormal_melanocyte_morpholog2.53172943
18MP0001986_abnormal_taste_sensitivity2.52737812
19MP0002735_abnormal_chemical_nociception2.52375665
20MP0005423_abnormal_somatic_nervous2.36259963
21MP0006276_abnormal_autonomic_nervous2.35209240
22MP0003123_paternal_imprinting2.26124917
23MP0003635_abnormal_synaptic_transmissio2.24934359
24MP0005645_abnormal_hypothalamus_physiol2.24064993
25MP0003566_abnormal_cell_adhesion2.23635495
26MP0005623_abnormal_meninges_morphology2.22216386
27MP0001968_abnormal_touch/_nociception2.18772077
28MP0005257_abnormal_intraocular_pressure2.13544120
29MP0005646_abnormal_pituitary_gland2.13189077
30MP0005195_abnormal_posterior_eye2.12364808
31MP0001849_ear_inflammation2.07733740
32MP0001324_abnormal_eye_pigmentation2.07707875
33MP0003091_abnormal_cell_migration2.06970858
34MP0004858_abnormal_nervous_system2.03784349
35MP0001188_hyperpigmentation2.02941550
36MP0002063_abnormal_learning/memory/cond2.02531048
37MP0001348_abnormal_lacrimal_gland1.97311729
38MP0002638_abnormal_pupillary_reflex1.96981332
39MP0002229_neurodegeneration1.96404864
40MP0000778_abnormal_nervous_system1.96341037
41MP0009046_muscle_twitch1.94250547
42MP0002184_abnormal_innervation1.92741860
43MP0002272_abnormal_nervous_system1.92143819
44MP0002653_abnormal_ependyma_morphology1.90544441
45MP0005076_abnormal_cell_differentiation1.86385157
46MP0003787_abnormal_imprinting1.85587930
47MP0009745_abnormal_behavioral_response1.84589384
48MP0002064_seizures1.83673049
49MP0003300_gastrointestinal_ulcer1.80714252
50MP0002752_abnormal_somatic_nervous1.80648219
51MP0002736_abnormal_nociception_after1.77687722
52MP0002572_abnormal_emotion/affect_behav1.74467338
53* MP0002882_abnormal_neuron_morphology1.73744540
54MP0001486_abnormal_startle_reflex1.72321845
55MP0004885_abnormal_endolymph1.63713742
56MP0002067_abnormal_sensory_capabilities1.61906171
57MP0010234_abnormal_vibrissa_follicle1.61682046
58MP0003303_peritoneal_inflammation1.60719273
59MP0001958_emphysema1.59132849
60MP0005058_abnormal_lysosome_morphology1.57289890
61MP0000537_abnormal_urethra_morphology1.55049258
62MP0005391_vision/eye_phenotype1.54405802
63MP0000372_irregular_coat_pigmentation1.51474612
64MP0003690_abnormal_glial_cell1.51163607
65MP0000604_amyloidosis1.51022759
66MP0002089_abnormal_postnatal_growth/wei1.48630348
67MP0005171_absent_coat_pigmentation1.45870432
68MP0002557_abnormal_social/conspecific_i1.43637376
69MP0001970_abnormal_pain_threshold1.42127234
70MP0004185_abnormal_adipocyte_glucose1.36057002
71MP0000015_abnormal_ear_pigmentation1.33937602
72MP0003172_abnormal_lysosome_physiology1.33579714
73MP0002751_abnormal_autonomic_nervous1.33504670
74MP0000920_abnormal_myelination1.31991876
75MP0004811_abnormal_neuron_physiology1.30555860
76MP0002160_abnormal_reproductive_system1.29686978
77MP0001963_abnormal_hearing_physiology1.28980456
78MP0003279_aneurysm1.28398902
79MP0006292_abnormal_olfactory_placode1.24932448
80MP0000534_abnormal_ureter_morphology1.24325838
81MP0001502_abnormal_circadian_rhythm1.20565864
82MP0002733_abnormal_thermal_nociception1.20137745
83MP0003453_abnormal_keratinocyte_physiol1.19640381
84MP0004272_abnormal_basement_membrane1.18578269
85MP0008260_abnormal_autophagy1.18096055
86MP0004742_abnormal_vestibular_system1.17314222
87MP0003879_abnormal_hair_cell1.13090257
88MP0002090_abnormal_vision1.11028159
89MP0002876_abnormal_thyroid_physiology1.10346148
90MP0009053_abnormal_anal_canal1.08996612
91MP0004510_myositis1.08524881
92MP0010386_abnormal_urinary_bladder1.08027894
93MP0000631_abnormal_neuroendocrine_gland1.07758773
94MP0003122_maternal_imprinting1.07478553
95MP0004924_abnormal_behavior1.06955156
96MP0005386_behavior/neurological_phenoty1.06955156
97MP0002896_abnormal_bone_mineralization1.06336286
98MP0000026_abnormal_inner_ear1.05143147
99MP0009780_abnormal_chondrocyte_physiolo1.05073372
100MP0008569_lethality_at_weaning1.04612427
101MP0003075_altered_response_to1.03892097
102MP0003950_abnormal_plasma_membrane1.02702640
103MP0000678_abnormal_parathyroid_gland1.02154502
104MP0002822_catalepsy1.02009461
105MP0000955_abnormal_spinal_cord1.01602746
106MP0009672_abnormal_birth_weight1.00732969
107MP0009278_abnormal_bone_marrow1.00214090
108MP0000566_synostosis0.99805002
109MP0010352_gastrointestinal_tract_polyps0.97824950
110MP0001485_abnormal_pinna_reflex0.97526594
111MP0005666_abnormal_adipose_tissue0.95199575
112MP0003878_abnormal_ear_physiology0.93919554
113MP0005377_hearing/vestibular/ear_phenot0.93919554
114MP0001905_abnormal_dopamine_level0.93603575
115MP0005023_abnormal_wound_healing0.93236902
116MP0004134_abnormal_chest_morphology0.92333175
117* MP0002152_abnormal_brain_morphology0.91560545
118MP0005451_abnormal_body_composition0.90780729
119MP0000733_abnormal_muscle_development0.89777933
120MP0002066_abnormal_motor_capabilities/c0.87763548
121MP0009379_abnormal_foot_pigmentation0.87432265
122MP0002249_abnormal_larynx_morphology0.87129825
123MP0008874_decreased_physiological_sensi0.87128797
124MP0003283_abnormal_digestive_organ0.85689766
125MP0000579_abnormal_nail_morphology0.85523608
126MP0001915_intracranial_hemorrhage0.84197704
127MP0003634_abnormal_glial_cell0.81236856
128MP0010368_abnormal_lymphatic_system0.80184796
129MP0001764_abnormal_homeostasis0.79702255
130MP0001501_abnormal_sleep_pattern0.79333722
131MP0005375_adipose_tissue_phenotype0.78778925
132MP0000767_abnormal_smooth_muscle0.78343897
133MP0005621_abnormal_cell_physiology0.77863888
134MP0000858_altered_metastatic_potential0.77782195
135MP0003115_abnormal_respiratory_system0.77249802
136MP0004142_abnormal_muscle_tone0.76938539
137MP0002233_abnormal_nose_morphology0.76330723
138MP0009840_abnormal_foam_cell0.75702601
139MP0003191_abnormal_cellular_cholesterol0.75691713
140MP0001299_abnormal_eye_distance/0.75175565
141MP0002998_abnormal_bone_remodeling0.74991815
142MP0005275_abnormal_skin_tensile0.74987095
143MP0004947_skin_inflammation0.74251285
144MP0003385_abnormal_body_wall0.73988266
145MP0002060_abnormal_skin_morphology0.73092799
146MP0004085_abnormal_heartbeat0.71533709
147MP0004233_abnormal_muscle_weight0.70728078
148* MP0003861_abnormal_nervous_system0.69959936
149MP0001177_atelectasis0.69468532
150MP0001440_abnormal_grooming_behavior0.67788565
151MP0002796_impaired_skin_barrier0.67417848
152MP0003632_abnormal_nervous_system0.66485273
153MP0001542_abnormal_bone_strength0.65896862
154MP0000003_abnormal_adipose_tissue0.65845682
155MP0000569_abnormal_digit_pigmentation0.65813756
156MP0005389_reproductive_system_phenotype0.65231927
157MP0003942_abnormal_urinary_system0.62436567
158MP0004782_abnormal_surfactant_physiolog0.62108576
159MP0003121_genomic_imprinting0.59639157
160MP0005187_abnormal_penis_morphology0.58158133
161MP0002127_abnormal_cardiovascular_syste0.58154632
162MP0003631_nervous_system_phenotype0.56826349
163MP0003183_abnormal_peptide_metabolism0.56313668
164MP0002102_abnormal_ear_morphology0.55828431
165MP0005197_abnormal_uvea_morphology0.53814605
166MP0003633_abnormal_nervous_system0.52738094
167MP0002938_white_spotting0.51442085

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.54090432
2Bony spicule pigmentary retinopathy (HP:0007737)7.29250639
3Abnormal rod and cone electroretinograms (HP:0008323)6.94418977
4Absent rod-and cone-mediated responses on ERG (HP:0007688)6.80589477
5Chorioretinal atrophy (HP:0000533)5.74896546
6Central scotoma (HP:0000603)5.56738838
7Pigmentary retinal degeneration (HP:0001146)5.55808068
8Abnormality of macular pigmentation (HP:0008002)5.38694953
9Dyschromatopsia (HP:0007641)5.24050481
10Pendular nystagmus (HP:0012043)5.18717567
11Attenuation of retinal blood vessels (HP:0007843)5.01843450
12Scotoma (HP:0000575)4.70782599
13Decreased central vision (HP:0007663)4.58555583
14Gait imbalance (HP:0002141)4.37742066
15Abolished electroretinogram (ERG) (HP:0000550)4.29773158
16Febrile seizures (HP:0002373)4.20085205
17Congenital primary aphakia (HP:0007707)4.15763313
18Nephrogenic diabetes insipidus (HP:0009806)3.92676931
19Medial flaring of the eyebrow (HP:0010747)3.89544726
20Neurofibrillary tangles (HP:0002185)3.77591037
21Type II diabetes mellitus (HP:0005978)3.76475967
22Photophobia (HP:0000613)3.68621095
23Obstructive sleep apnea (HP:0002870)3.62373661
24Choroideremia (HP:0001139)3.58565887
25Severe visual impairment (HP:0001141)3.58314618
26Protrusio acetabuli (HP:0003179)3.55302932
27Atonic seizures (HP:0010819)3.49656219
28Cerebral inclusion bodies (HP:0100314)3.46415674
29Hyperacusis (HP:0010780)3.42709348
30Retinitis pigmentosa (HP:0000510)3.40137930
31Poor coordination (HP:0002370)3.36364716
32Increased corneal curvature (HP:0100692)3.34679845
33Keratoconus (HP:0000563)3.34679845
34Supranuclear gaze palsy (HP:0000605)3.32806557
35Hypothermia (HP:0002045)3.28643558
36Epileptic encephalopathy (HP:0200134)3.27212336
37Pancreatic fibrosis (HP:0100732)3.24754196
38Genital tract atresia (HP:0001827)3.22936956
39Premature rupture of membranes (HP:0001788)3.17543841
40Macular degeneration (HP:0000608)3.16484012
41Focal motor seizures (HP:0011153)3.14228497
42Vaginal atresia (HP:0000148)3.12584732
43Constricted visual fields (HP:0001133)3.06788846
44Insomnia (HP:0100785)3.04995688
45Cone-rod dystrophy (HP:0000548)3.02502611
46True hermaphroditism (HP:0010459)2.98635112
47Vitreoretinal degeneration (HP:0000655)2.82473861
48Hyperventilation (HP:0002883)2.81804022
49Shallow orbits (HP:0000586)2.79004994
50Abnormal hair whorl (HP:0010721)2.77480188
51Aplasia/Hypoplasia of the lens (HP:0008063)2.64261750
52Focal seizures (HP:0007359)2.59691837
53Arterial tortuosity (HP:0005116)2.57763791
54Cerebral aneurysm (HP:0004944)2.56918049
55Vascular tortuosity (HP:0004948)2.51862407
56Specific learning disability (HP:0001328)2.38037279
57Hyperparathyroidism (HP:0000843)2.34993318
58Upper limb amyotrophy (HP:0009129)2.33455586
59Distal upper limb amyotrophy (HP:0007149)2.33455586
60Genu recurvatum (HP:0002816)2.29413942
61Disproportionate tall stature (HP:0001519)2.27389530
62Annular pancreas (HP:0001734)2.26204379
63Progressive cerebellar ataxia (HP:0002073)2.25976234
64Turricephaly (HP:0000262)2.25108036
65Bladder diverticulum (HP:0000015)2.23347138
66Lower limb amyotrophy (HP:0007210)2.22506227
67Optic disc pallor (HP:0000543)2.22261634
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22250795
69Long palpebral fissure (HP:0000637)2.21986598
70Posterior subcapsular cataract (HP:0007787)2.21413955
71Mitral regurgitation (HP:0001653)2.21293422
72Atrophic scars (HP:0001075)2.20910345
73Ankyloglossia (HP:0010296)2.20214658
74Broad face (HP:0000283)2.19996517
75Pointed chin (HP:0000307)2.18132781
76Myokymia (HP:0002411)2.17177130
77Neuronal loss in central nervous system (HP:0002529)2.14024850
78Achilles tendon contracture (HP:0001771)2.13105083
79Apathy (HP:0000741)2.12535871
80Fragile skin (HP:0001030)2.10217755
81Absence seizures (HP:0002121)2.10053006
82Hypercortisolism (HP:0001578)2.07955365
83Ulnar bowing (HP:0003031)2.05663768
84Abnormality of binocular vision (HP:0011514)2.04665613
85Diplopia (HP:0000651)2.04665613
86Pheochromocytoma (HP:0002666)2.03957604
87Hand muscle atrophy (HP:0009130)2.01129967
88Fetal akinesia sequence (HP:0001989)1.99900703
89Cystic liver disease (HP:0006706)1.99351809
90Limb dystonia (HP:0002451)1.98967067
91Diminished motivation (HP:0000745)1.98529834
92Elfin facies (HP:0004428)1.97873743
93Action tremor (HP:0002345)1.97697725
94Thin bony cortex (HP:0002753)1.97167950
95Arnold-Chiari malformation (HP:0002308)1.96942287
96Mitral valve prolapse (HP:0001634)1.95938875
97Pancreatic cysts (HP:0001737)1.95630790
98Failure to thrive in infancy (HP:0001531)1.95244248
99Renal duplication (HP:0000075)1.95006708
100Neonatal short-limb short stature (HP:0008921)1.94683716
101Vertebral arch anomaly (HP:0008438)1.94010158
102Insidious onset (HP:0003587)1.93789099
103Termporal pattern (HP:0011008)1.93789099
104Vertebral compression fractures (HP:0002953)1.93244294
105Broad metatarsal (HP:0001783)1.92913982
106Hammertoe (HP:0001765)1.92889828
107Postaxial hand polydactyly (HP:0001162)1.92641477
108Molar tooth sign on MRI (HP:0002419)1.92372543
109Abnormality of midbrain morphology (HP:0002418)1.92372543
110Overriding aorta (HP:0002623)1.92232218
111Broad foot (HP:0001769)1.91531920
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.91433751
113Distal lower limb amyotrophy (HP:0008944)1.90424094
114Deep palmar crease (HP:0006191)1.90126527
115Neuroendocrine neoplasm (HP:0100634)1.89900920
116Depression (HP:0000716)1.89808213
117Truncal ataxia (HP:0002078)1.89779594
118Hyperextensible skin (HP:0000974)1.87174898
119Torticollis (HP:0000473)1.86721872
120Abnormality of the Achilles tendon (HP:0005109)1.86606480
121Wormian bones (HP:0002645)1.86077929
122Dialeptic seizures (HP:0011146)1.85152303
123Congenital sensorineural hearing impairment (HP:0008527)1.83432628
124Flat acetabular roof (HP:0003180)1.83366754
125Broad-based gait (HP:0002136)1.83275064
126Hypoventilation (HP:0002791)1.83132271
127Overgrowth (HP:0001548)1.81652229
128Protruding tongue (HP:0010808)1.80878088
129Bowel diverticulosis (HP:0005222)1.80438673
130Thyroid carcinoma (HP:0002890)1.79898694
131Dilatation of the ascending aorta (HP:0005111)1.79466372
132Wide nasal bridge (HP:0000431)1.78951703
133Bronchomalacia (HP:0002780)1.78371938
134Abnormality of oral frenula (HP:0000190)1.78171670
135Increased variability in muscle fiber diameter (HP:0003557)1.77667416
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.76267839
137Hypercalcemia (HP:0003072)1.75728263
138Peripheral hypomyelination (HP:0007182)1.74785794
139Patellar dislocation (HP:0002999)1.74068256
140Papillary thyroid carcinoma (HP:0002895)1.73550262
141Generalized tonic-clonic seizures (HP:0002069)1.73449734
142Absent eyebrow (HP:0002223)1.73346972
143Segmental peripheral demyelination/remyelination (HP:0003481)1.73215236
144Asymmetry of the thorax (HP:0001555)1.73177872
145Bradycardia (HP:0001662)1.73098723
146Decreased motor nerve conduction velocity (HP:0003431)1.72868179
147Absent speech (HP:0001344)1.71179080
148Curly hair (HP:0002212)1.70065825
149Progressive visual loss (HP:0000529)1.70008824
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69334731
151Spastic gait (HP:0002064)1.69117357
152Asthma (HP:0002099)1.68472361
153Astigmatism (HP:0000483)1.68301190
154Spinal rigidity (HP:0003306)1.67846188
155Ankle contracture (HP:0006466)1.67807332
156Dysmetric saccades (HP:0000641)1.66772822
157Spinal cord compression (HP:0002176)1.66635031
158Visual hallucinations (HP:0002367)1.65576150
159Preaxial hand polydactyly (HP:0001177)1.64696271
160Amblyopia (HP:0000646)1.64691142
161Growth hormone excess (HP:0000845)1.64609651
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.64579880
163Hypoplasia of the fovea (HP:0007750)1.64579880
164Precocious puberty (HP:0000826)1.64466858
165Renovascular hypertension (HP:0100817)1.64171195
166Macroorchidism (HP:0000053)1.63979287
167Blue sclerae (HP:0000592)1.63718623
168Gaze-evoked nystagmus (HP:0000640)1.63626677
169Aneurysm (HP:0002617)1.63534448
170Aortic dissection (HP:0002647)1.63460502
171Sclerocornea (HP:0000647)1.62743288
172Abnormality of the fovea (HP:0000493)1.62652442
173Lower limb asymmetry (HP:0100559)1.62246797
174Left ventricular hypertrophy (HP:0001712)1.60584003
175Postaxial foot polydactyly (HP:0001830)1.58618026
176Onion bulb formation (HP:0003383)1.58050888
177Abnormality of the lower motor neuron (HP:0002366)1.57989912
178Ankle clonus (HP:0011448)1.57716398
179Aplasia involving bones of the extremities (HP:0009825)1.57413785
180Aplasia involving bones of the upper limbs (HP:0009823)1.57413785
181Aplasia of the phalanges of the hand (HP:0009802)1.57413785
182Distal sensory impairment (HP:0002936)1.57324115
183Urinary bladder sphincter dysfunction (HP:0002839)1.56886529
184Relative macrocephaly (HP:0004482)1.55783287
185Mild short stature (HP:0003502)1.55672779
186Papilledema (HP:0001085)1.54899764
187Rapidly progressive (HP:0003678)1.54427521
188Blue irides (HP:0000635)1.54019870
189Decreased testicular size (HP:0008734)1.53132580
190Submucous cleft hard palate (HP:0000176)1.53020169
191Aqueductal stenosis (HP:0002410)1.48028305
192Impaired pain sensation (HP:0007328)1.47888501
193Abnormality of pain sensation (HP:0010832)1.47888501
194Dental crowding (HP:0000678)1.47078989
195Abnormality of hair growth rate (HP:0011363)1.46873111
196Slow-growing hair (HP:0002217)1.46873111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.66968190
2PRPF4B4.68247785
3TRIB33.75824932
4AKT33.66548033
5MARK13.11129235
6SGK22.81224753
7MAP2K72.75414203
8SIK32.69224384
9MAPK132.64730692
10ERBB32.58528096
11NTRK12.58393115
12LATS22.56096986
13GRK12.55905911
14ICK2.54369208
15SGK2232.30358424
16SGK4942.30358424
17DAPK22.17409534
18PLK22.11670493
19MINK12.10324623
20SMG12.09875898
21PDGFRA2.01238655
22MAP3K41.95788164
23MAP3K121.93715435
24CDK121.91753324
25SGK31.89690799
26KSR21.87984724
27SIK11.86821154
28TYRO31.74340018
29ARAF1.65749056
30ERN11.64722483
31BMPR21.59555361
32BRAF1.56704605
33MAP3K101.53927135
34YES11.53336933
35NTRK31.49955230
36MAP3K131.49668125
37CCNB11.48811990
38MAPKAPK31.46515057
39RPS6KA21.44178097
40FGFR41.43200559
41DAPK11.39579418
42MARK21.35852642
43RIPK41.30439793
44PTK21.27089503
45NTRK21.24188120
46IRAK31.23465964
47EEF2K1.20214090
48BCR1.19277679
49BMPR1B1.16537505
50STK241.16080267
51MOS1.13611329
52EPHB11.13272625
53PKN21.09243990
54TESK11.04767258
55EPHB21.03614493
56PRKCH0.99137308
57PLK30.97334530
58DYRK20.95754419
59MAP2K40.94303923
60GRK50.94228779
61ALK0.92159628
62MTOR0.92072217
63TSSK60.90060572
64CAMK1G0.89490098
65PRKCG0.88974776
66DDR20.88915046
67PDPK10.86075670
68RET0.85040501
69MAP3K10.84727668
70CDK11A0.84638971
71UHMK10.84316123
72PINK10.83324229
73TTN0.82548470
74CAMKK20.82442644
75PTK60.82010559
76CDK50.81520401
77CDC42BPA0.80700864
78EPHA40.80474749
79RPS6KB10.80110366
80CAMK1D0.78986029
81STK380.78831104
82STK38L0.77266736
83TAOK10.70241362
84ADRBK10.70173632
85PRKCE0.70135511
86PDGFRB0.70068258
87TAOK20.69289957
88PRKD20.68805093
89PAK20.68467056
90ROCK20.68198443
91DMPK0.66281525
92MAP3K110.66107538
93LMTK20.63614873
94PRKD30.60118507
95CAMKK10.59422183
96PDK10.59319110
97RIPK10.59187079
98PAK40.58542331
99KSR10.58426009
100LIMK10.58393037
101WNK10.57697577
102PBK0.56326330
103LRRK20.56013242
104TNIK0.55547663
105PIM20.55449233
106CSNK1G20.54856806
107TRPM70.54123601
108SIK20.53555822
109MAP3K60.53120938
110MAP3K20.53042469
111EPHA20.52523954
112PRKCZ0.52137422
113CAMK2A0.51386315
114MKNK20.51380173
115DYRK1A0.51118475
116SCYL20.51024638
117FGFR30.50082856
118CAMK40.49312597
119MAPK100.49302851
120CDK180.48865170
121FRK0.45391763
122MAPK120.44940781
123MAP3K80.44885053
124CDK30.44711009
125BMX0.44685548
126MAP2K10.44257072
127CSNK1A1L0.44143206
128DYRK1B0.44099886
129IRAK20.43906583
130RAF10.43206235
131MAP3K140.42430960
132FYN0.41946233
133FER0.41683979
134MAPK80.41556968
135MAP2K30.41050145
136RPS6KC10.39726170
137RPS6KL10.39726170
138CSNK1G30.39506402
139SGK10.39472095
140MAPK70.39327051
141PRKG20.38994736
142FES0.38833407
143CAMK2B0.38500615
144RPS6KA60.37982845
145ADRBK20.36731934
146CDK190.36676739
147JAK10.35608936
148CDK60.35589313
149MAP3K90.35494323
150PAK60.35336491
151CDK140.34967995
152ROCK10.34078709
153MAPKAPK50.33514639
154TNK20.33412814
155PHKG20.33222817
156PHKG10.33222817
157PRKCB0.33092707
158OXSR10.32261073
159CDK150.32252358
160SRPK10.27417748
161HIPK20.27199418
162MAPK90.26041916
163ZAK0.25819806
164GSK3B0.25582321
165CAMK2D0.24575787

Predicted pathways (KEGG)

RankGene SetZ-score
1* Phototransduction_Homo sapiens_hsa047449.87822665
2Synaptic vesicle cycle_Homo sapiens_hsa047213.81176876
3* Olfactory transduction_Homo sapiens_hsa047403.18096321
4Collecting duct acid secretion_Homo sapiens_hsa049662.10969543
5Nicotine addiction_Homo sapiens_hsa050332.08944106
6* GABAergic synapse_Homo sapiens_hsa047271.95110233
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94817930
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92335570
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91088901
10* Dopaminergic synapse_Homo sapiens_hsa047281.88196865
11* Morphine addiction_Homo sapiens_hsa050321.86554731
12* Circadian entrainment_Homo sapiens_hsa047131.86264105
13Taste transduction_Homo sapiens_hsa047421.76240505
14* Serotonergic synapse_Homo sapiens_hsa047261.72406744
15Chronic myeloid leukemia_Homo sapiens_hsa052201.72359262
16Prion diseases_Homo sapiens_hsa050201.70453560
17* Cholinergic synapse_Homo sapiens_hsa047251.62176153
18VEGF signaling pathway_Homo sapiens_hsa043701.62046506
19* Glutamatergic synapse_Homo sapiens_hsa047241.59287768
20Renal cell carcinoma_Homo sapiens_hsa052111.57160203
21Insulin secretion_Homo sapiens_hsa049111.57058758
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46821245
23Vibrio cholerae infection_Homo sapiens_hsa051101.42557580
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42109909
25Long-term potentiation_Homo sapiens_hsa047201.35274568
26Phospholipase D signaling pathway_Homo sapiens_hsa040721.32703504
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30522736
28Notch signaling pathway_Homo sapiens_hsa043301.29541188
29Amphetamine addiction_Homo sapiens_hsa050311.28430075
30Pancreatic cancer_Homo sapiens_hsa052121.26845523
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26104131
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23010881
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22887333
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.21929219
35Acute myeloid leukemia_Homo sapiens_hsa052211.21783361
36Endometrial cancer_Homo sapiens_hsa052131.20618865
37Focal adhesion_Homo sapiens_hsa045101.16669253
38B cell receptor signaling pathway_Homo sapiens_hsa046621.15598715
39Adherens junction_Homo sapiens_hsa045201.12077007
40Axon guidance_Homo sapiens_hsa043601.10021302
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09047432
42Bladder cancer_Homo sapiens_hsa052191.08366323
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05866083
44Amoebiasis_Homo sapiens_hsa051461.05861943
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05304407
46Proteoglycans in cancer_Homo sapiens_hsa052051.02801088
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02727734
48Choline metabolism in cancer_Homo sapiens_hsa052310.97531876
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96003336
50mTOR signaling pathway_Homo sapiens_hsa041500.95625392
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93248189
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92505552
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92401231
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.92172197
55ErbB signaling pathway_Homo sapiens_hsa040120.91190737
56Renin secretion_Homo sapiens_hsa049240.87239106
57Salivary secretion_Homo sapiens_hsa049700.86884899
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86350900
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86137885
60Oxytocin signaling pathway_Homo sapiens_hsa049210.85717881
61MicroRNAs in cancer_Homo sapiens_hsa052060.84203448
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.83810746
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83798252
64Gastric acid secretion_Homo sapiens_hsa049710.83239398
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83040426
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82042581
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80593965
68ECM-receptor interaction_Homo sapiens_hsa045120.79588045
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79020824
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78996462
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78629977
72Colorectal cancer_Homo sapiens_hsa052100.78152539
73cAMP signaling pathway_Homo sapiens_hsa040240.77536626
74Long-term depression_Homo sapiens_hsa047300.75587408
75Cocaine addiction_Homo sapiens_hsa050300.75231889
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75013219
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74786093
78Melanoma_Homo sapiens_hsa052180.74382213
79Phagosome_Homo sapiens_hsa041450.71835540
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.71567702
81AMPK signaling pathway_Homo sapiens_hsa041520.71018327
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69488306
83Melanogenesis_Homo sapiens_hsa049160.69388675
84Shigellosis_Homo sapiens_hsa051310.68871382
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68392895
86Calcium signaling pathway_Homo sapiens_hsa040200.68249651
87Osteoclast differentiation_Homo sapiens_hsa043800.68176572
88Glioma_Homo sapiens_hsa052140.67939365
89HIF-1 signaling pathway_Homo sapiens_hsa040660.67072581
90* Ras signaling pathway_Homo sapiens_hsa040140.65162724
91GnRH signaling pathway_Homo sapiens_hsa049120.64888614
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64856116
93Hepatitis B_Homo sapiens_hsa051610.64211346
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63274317
95Small cell lung cancer_Homo sapiens_hsa052220.61883033
96Gap junction_Homo sapiens_hsa045400.60494010
97Other glycan degradation_Homo sapiens_hsa005110.59797577
98Tight junction_Homo sapiens_hsa045300.57808881
99MAPK signaling pathway_Homo sapiens_hsa040100.56834396
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56299533
101Rheumatoid arthritis_Homo sapiens_hsa053230.55793213
102Circadian rhythm_Homo sapiens_hsa047100.54357837
103* Alcoholism_Homo sapiens_hsa050340.52216261
104Wnt signaling pathway_Homo sapiens_hsa043100.52096154
105Regulation of autophagy_Homo sapiens_hsa041400.50844640
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50298215
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48612786
108Oocyte meiosis_Homo sapiens_hsa041140.48373779
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.47029873
110Inositol phosphate metabolism_Homo sapiens_hsa005620.43773658
111Type II diabetes mellitus_Homo sapiens_hsa049300.43405163
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42737192
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42654295
114Hepatitis C_Homo sapiens_hsa051600.41261799
115* Chemokine signaling pathway_Homo sapiens_hsa040620.36154557
116Hedgehog signaling pathway_Homo sapiens_hsa043400.34763936
117Estrogen signaling pathway_Homo sapiens_hsa049150.34662852
118Insulin signaling pathway_Homo sapiens_hsa049100.34129191
119Hippo signaling pathway_Homo sapiens_hsa043900.33839446
120Prolactin signaling pathway_Homo sapiens_hsa049170.32384814
121Thyroid cancer_Homo sapiens_hsa052160.32290533
122Endocytosis_Homo sapiens_hsa041440.31358017
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30952727
124Rap1 signaling pathway_Homo sapiens_hsa040150.28954652
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28554338
126Prostate cancer_Homo sapiens_hsa052150.27874505
127Glucagon signaling pathway_Homo sapiens_hsa049220.27243375
128mRNA surveillance pathway_Homo sapiens_hsa030150.26991197
129Dilated cardiomyopathy_Homo sapiens_hsa054140.24834869
130Thyroid hormone synthesis_Homo sapiens_hsa049180.23541748
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23455605
132FoxO signaling pathway_Homo sapiens_hsa040680.23296159
133Basal cell carcinoma_Homo sapiens_hsa052170.21228423
134Ovarian steroidogenesis_Homo sapiens_hsa049130.20714828
135Non-small cell lung cancer_Homo sapiens_hsa052230.18318785
136Purine metabolism_Homo sapiens_hsa002300.17928645
137* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17274335
138Type I diabetes mellitus_Homo sapiens_hsa049400.16923579
139Alzheimers disease_Homo sapiens_hsa050100.15274197
140Salmonella infection_Homo sapiens_hsa051320.13687116
141N-Glycan biosynthesis_Homo sapiens_hsa005100.13351557
142Huntingtons disease_Homo sapiens_hsa050160.12888005

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