GNB1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.55944663
2DNA deamination (GO:0045006)5.52145979
3maturation of SSU-rRNA (GO:0030490)5.32188396
4DNA strand elongation involved in DNA replication (GO:0006271)5.05188917
5telomere maintenance via semi-conservative replication (GO:0032201)4.95966274
6regulation of mitochondrial translation (GO:0070129)4.95182123
7DNA strand elongation (GO:0022616)4.76959565
8viral transcription (GO:0019083)4.72482138
9translational termination (GO:0006415)4.62569876
10ribosomal small subunit biogenesis (GO:0042274)4.61208593
11DNA replication checkpoint (GO:0000076)4.49548791
12DNA replication initiation (GO:0006270)4.49111745
13ribosomal large subunit biogenesis (GO:0042273)4.42492886
14telomere maintenance via recombination (GO:0000722)4.40384279
15nucleobase biosynthetic process (GO:0046112)4.37339726
16formation of translation preinitiation complex (GO:0001731)4.29535383
17translational elongation (GO:0006414)4.20760289
18translational initiation (GO:0006413)4.19585729
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13974426
20purine nucleobase biosynthetic process (GO:0009113)4.13701669
21ribonucleoprotein complex biogenesis (GO:0022613)4.12513588
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05120031
23mitotic recombination (GO:0006312)4.04862345
24mitotic metaphase plate congression (GO:0007080)4.04122555
25transcription from mitochondrial promoter (GO:0006390)4.01472984
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.00676517
27mitochondrial RNA metabolic process (GO:0000959)4.00070293
28telomere maintenance via telomere lengthening (GO:0010833)3.94279738
29cotranslational protein targeting to membrane (GO:0006613)3.93926259
30proteasome assembly (GO:0043248)3.93800511
31protein targeting to ER (GO:0045047)3.92690288
32ribosome biogenesis (GO:0042254)3.92492779
33ATP synthesis coupled proton transport (GO:0015986)3.85344909
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85344909
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79235225
36spliceosomal snRNP assembly (GO:0000387)3.78675111
37mitochondrial respiratory chain complex assembly (GO:0033108)3.76907436
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72004001
39protein targeting to mitochondrion (GO:0006626)3.71458880
40rRNA processing (GO:0006364)3.71445247
41protein localization to endoplasmic reticulum (GO:0070972)3.70990714
42metallo-sulfur cluster assembly (GO:0031163)3.70811485
43iron-sulfur cluster assembly (GO:0016226)3.70811485
44tRNA methylation (GO:0030488)3.70751372
45ribosome assembly (GO:0042255)3.70330150
46CENP-A containing nucleosome assembly (GO:0034080)3.69409771
47pseudouridine synthesis (GO:0001522)3.68834969
48chaperone-mediated protein transport (GO:0072321)3.68433399
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.67667573
50chromatin remodeling at centromere (GO:0031055)3.67603736
51DNA unwinding involved in DNA replication (GO:0006268)3.67211776
52cellular protein complex disassembly (GO:0043624)3.66469515
53viral life cycle (GO:0019058)3.64682096
54protein complex biogenesis (GO:0070271)3.61623509
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61517688
56rRNA metabolic process (GO:0016072)3.58220073
57base-excision repair, AP site formation (GO:0006285)3.56856173
58NADH dehydrogenase complex assembly (GO:0010257)3.56517896
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56517896
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.56517896
61establishment of protein localization to mitochondrion (GO:0072655)3.55910210
62peptidyl-histidine modification (GO:0018202)3.55121441
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54699051
64rRNA modification (GO:0000154)3.53858647
65translation (GO:0006412)3.50360373
66metaphase plate congression (GO:0051310)3.49321209
67tRNA modification (GO:0006400)3.48687170
68IMP biosynthetic process (GO:0006188)3.46033709
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45585685
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43808189
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43426741
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43046061
73protein localization to kinetochore (GO:0034501)3.41504992
74transcription-coupled nucleotide-excision repair (GO:0006283)3.40333521
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39944456
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.39023156
77termination of RNA polymerase III transcription (GO:0006386)3.39023156
78DNA replication-dependent nucleosome assembly (GO:0006335)3.38032744
79DNA replication-dependent nucleosome organization (GO:0034723)3.38032744
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34696811
81DNA replication-independent nucleosome assembly (GO:0006336)3.33271969
82DNA replication-independent nucleosome organization (GO:0034724)3.33271969
83protein localization to mitochondrion (GO:0070585)3.32456953
84cellular component biogenesis (GO:0044085)3.31078058
85tRNA processing (GO:0008033)3.30969783
86protein complex disassembly (GO:0043241)3.28825893
87GDP-mannose metabolic process (GO:0019673)3.26276099
88ncRNA 3-end processing (GO:0043628)3.25638086
89peptidyl-arginine omega-N-methylation (GO:0035247)3.21340616
90rRNA methylation (GO:0031167)3.20371764
91respiratory electron transport chain (GO:0022904)3.19770250
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18258383
937-methylguanosine mRNA capping (GO:0006370)3.17932273
94protein insertion into membrane (GO:0051205)3.17183718
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16237461
96negative regulation of ligase activity (GO:0051352)3.16237461
97protein localization to chromosome, centromeric region (GO:0071459)3.16138112
98macromolecular complex disassembly (GO:0032984)3.16003507
99ncRNA processing (GO:0034470)3.14529889
100electron transport chain (GO:0022900)3.14463631
101histone exchange (GO:0043486)3.13680309
102IMP metabolic process (GO:0046040)3.13297432
103nuclear-transcribed mRNA catabolic process (GO:0000956)3.11952635
104protein deneddylation (GO:0000338)3.11619148
105mitotic nuclear envelope disassembly (GO:0007077)3.09715961
106RNA capping (GO:0036260)3.09303307
1077-methylguanosine RNA capping (GO:0009452)3.09303307
108transcription from RNA polymerase I promoter (GO:0006360)3.07670249
109base-excision repair (GO:0006284)3.07595736
110kinetochore assembly (GO:0051382)3.07442420
111spliceosomal complex assembly (GO:0000245)3.07344064
112tRNA metabolic process (GO:0006399)3.07314531
113kinetochore organization (GO:0051383)3.05493808
114cell cycle G1/S phase transition (GO:0044843)3.04515076
115G1/S transition of mitotic cell cycle (GO:0000082)3.04515076
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02995880
117regulation of double-strand break repair via homologous recombination (GO:0010569)3.01646645
118pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01615262
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01098373
120establishment of chromosome localization (GO:0051303)3.00784667
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97445911
122mRNA catabolic process (GO:0006402)2.97248805
123viral mRNA export from host cell nucleus (GO:0046784)2.97167803
124regulation of spindle organization (GO:0090224)2.96983103
125maturation of 5.8S rRNA (GO:0000460)2.96618537
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94676538
127UTP biosynthetic process (GO:0006228)2.94655523
128folic acid-containing compound biosynthetic process (GO:0009396)2.94603440
129mitotic sister chromatid segregation (GO:0000070)2.94594049
130folic acid metabolic process (GO:0046655)2.94068329
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93712777
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93712777
133guanosine-containing compound biosynthetic process (GO:1901070)2.93591449
134replication fork processing (GO:0031297)2.93525251
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93468047
136ncRNA metabolic process (GO:0034660)2.93304348
137protein K6-linked ubiquitination (GO:0085020)2.92330838
138histone arginine methylation (GO:0034969)2.92175186
139RNA catabolic process (GO:0006401)2.91956318
140termination of RNA polymerase I transcription (GO:0006363)2.91000563
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90865086
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90865086
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90662561
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90662561
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90662561
146establishment of integrated proviral latency (GO:0075713)2.89359525
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88845391
148positive regulation of ligase activity (GO:0051351)2.86930169
149regulation of cellular amino acid metabolic process (GO:0006521)2.86242974
150pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81981405
151negative regulation of B cell apoptotic process (GO:0002903)2.81692416
152inner mitochondrial membrane organization (GO:0007007)2.81518182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.58431919
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.40791993
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86666322
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51430629
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27798103
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.20932076
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.19614859
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.19016636
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.17766617
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08600722
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08559925
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04588262
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91527132
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87370841
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87043026
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80186872
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70857458
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70105881
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61396542
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46737711
21XRN2_22483619_ChIP-Seq_HELA_Human2.40294696
22VDR_23849224_ChIP-Seq_CD4+_Human2.38611385
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28902029
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26107409
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25148409
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.14324887
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11470936
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09608464
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05092587
30FOXP3_21729870_ChIP-Seq_TREG_Human2.04927563
31* GABP_19822575_ChIP-Seq_HepG2_Human2.00003031
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96353883
33TTF2_22483619_ChIP-Seq_HELA_Human1.93405625
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89914849
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.81811348
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79955430
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79561637
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78142571
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77675479
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72334743
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.70369616
42AR_21909140_ChIP-Seq_LNCAP_Human1.69504095
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69144364
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67609770
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67483747
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.66425769
47* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59268279
48ELK1_19687146_ChIP-ChIP_HELA_Human1.53573663
49CIITA_25753668_ChIP-Seq_RAJI_Human1.52679627
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52320113
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51365196
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49884935
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49549055
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49070042
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47370307
56KDM5A_27292631_Chip-Seq_BREAST_Human1.39018333
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37926814
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37278149
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36545510
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35766216
61MYC_22102868_ChIP-Seq_BL_Human1.30070013
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29540061
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.27778569
64FOXP1_21924763_ChIP-Seq_HESCs_Human1.24157675
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23917425
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23052880
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21814352
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21470453
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19432008
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17646803
71P68_20966046_ChIP-Seq_HELA_Human1.14846194
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14011057
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11403102
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09492327
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09304588
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08944325
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.07702586
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.07328864
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07103554
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06942078
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05285423
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04660232
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02623071
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.00033304
85BCL6_27268052_Chip-Seq_Bcells_Human0.97998479
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97949467
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97837728
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97199467
89MYC_18940864_ChIP-ChIP_HL60_Human0.96791651
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96702800
91* PHF8_20622854_ChIP-Seq_HELA_Human0.96698014
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96382286
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96301459
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.96265997
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96011172
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95279864
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94865661
98TFEB_21752829_ChIP-Seq_HELA_Human0.94394926
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.94286601
100SPI1_23547873_ChIP-Seq_NB4_Human0.94211486
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92173410
102LXR_22292898_ChIP-Seq_THP-1_Human0.92111464
103MAF_26560356_Chip-Seq_TH2_Human0.92084047
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91117786
105BCOR_27268052_Chip-Seq_Bcells_Human0.89056544
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87923200
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87489775
108VDR_21846776_ChIP-Seq_THP-1_Human0.85129451
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84891506
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84471174
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83659078
112ZNF263_19887448_ChIP-Seq_K562_Human0.82732279
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82420398
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81096379
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77881605
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76537809
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75813216
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.74521144
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74217428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.18247808
2MP0004957_abnormal_blastocyst_morpholog4.97892319
3MP0010094_abnormal_chromosome_stability4.80575316
4MP0003111_abnormal_nucleus_morphology4.55585896
5MP0003077_abnormal_cell_cycle4.19675029
6MP0008057_abnormal_DNA_replication3.80658927
7MP0008058_abnormal_DNA_repair3.77020350
8MP0008932_abnormal_embryonic_tissue2.93853694
9MP0008007_abnormal_cellular_replicative2.73090427
10MP0003123_paternal_imprinting2.62196723
11MP0002396_abnormal_hematopoietic_system2.62098821
12MP0005451_abnormal_body_composition2.57810986
13MP0001730_embryonic_growth_arrest2.21836409
14MP0000490_abnormal_crypts_of2.18796428
15MP0003718_maternal_effect2.18709881
16MP0003786_premature_aging2.16618878
17MP0008877_abnormal_DNA_methylation2.06856727
18MP0009697_abnormal_copulation2.04656960
19MP0000350_abnormal_cell_proliferation2.00082227
20MP0009379_abnormal_foot_pigmentation1.96162015
21MP0009333_abnormal_splenocyte_physiolog1.80941653
22MP0001545_abnormal_hematopoietic_system1.69028977
23MP0005397_hematopoietic_system_phenotyp1.69028977
24MP0004808_abnormal_hematopoietic_stem1.61853811
25MP0003763_abnormal_thymus_physiology1.61691438
26MP0000678_abnormal_parathyroid_gland1.58569023
27MP0010352_gastrointestinal_tract_polyps1.58427413
28MP0002210_abnormal_sex_determination1.57295395
29MP0000313_abnormal_cell_death1.56720701
30MP0001697_abnormal_embryo_size1.55804062
31MP0002080_prenatal_lethality1.54195995
32MP0002019_abnormal_tumor_incidence1.52488370
33MP0001929_abnormal_gametogenesis1.52466508
34MP0005380_embryogenesis_phenotype1.49757499
35MP0001672_abnormal_embryogenesis/_devel1.49757499
36MP0003806_abnormal_nucleotide_metabolis1.48749157
37MP0008995_early_reproductive_senescence1.48320862
38MP0006292_abnormal_olfactory_placode1.45153193
39MP0002132_abnormal_respiratory_system1.44703725
40MP0008875_abnormal_xenobiotic_pharmacok1.39018873
41MP0001145_abnormal_male_reproductive1.38766373
42MP0002736_abnormal_nociception_after1.35870809
43MP0000372_irregular_coat_pigmentation1.32579258
44MP0001727_abnormal_embryo_implantation1.32233246
45MP0006036_abnormal_mitochondrial_physio1.32105526
46MP0000358_abnormal_cell_content/1.31090490
47MP0003984_embryonic_growth_retardation1.29247368
48MP0002085_abnormal_embryonic_tissue1.29003482
49MP0005083_abnormal_biliary_tract1.27712815
50MP0000703_abnormal_thymus_morphology1.25957517
51MP0002088_abnormal_embryonic_growth/wei1.24530607
52MP0000049_abnormal_middle_ear1.23979185
53MP0006035_abnormal_mitochondrial_morpho1.23437370
54MP0002398_abnormal_bone_marrow1.22671629
55MP0010307_abnormal_tumor_latency1.21817918
56MP0000653_abnormal_sex_gland1.21749766
57MP0002722_abnormal_immune_system1.19659101
58MP0003186_abnormal_redox_activity1.19043682
59MP0004233_abnormal_muscle_weight1.18957143
60MP0002160_abnormal_reproductive_system1.18357237
61MP0000689_abnormal_spleen_morphology1.15191483
62MP0005501_abnormal_skin_physiology1.09964812
63MP0002249_abnormal_larynx_morphology1.07815299
64MP0002084_abnormal_developmental_patter1.07324351
65MP0001905_abnormal_dopamine_level1.07015132
66MP0002086_abnormal_extraembryonic_tissu1.06631900
67MP0005075_abnormal_melanosome_morpholog1.05829149
68MP0001293_anophthalmia1.04895440
69MP0001968_abnormal_touch/_nociception1.02125151
70MP0002102_abnormal_ear_morphology1.02075007
71MP0003315_abnormal_perineum_morphology1.00802281
72MP0002429_abnormal_blood_cell0.99450018
73MP0005389_reproductive_system_phenotype0.96706018
74MP0001661_extended_life_span0.96019350
75MP0009840_abnormal_foam_cell0.95753920
76MP0002277_abnormal_respiratory_mucosa0.93208537
77MP0005410_abnormal_fertilization0.92071039
78MP0008789_abnormal_olfactory_epithelium0.91810777
79MP0009278_abnormal_bone_marrow0.90613154
80MP0004381_abnormal_hair_follicle0.89923102
81MP0003698_abnormal_male_reproductive0.89748330
82MP0003567_abnormal_fetal_cardiomyocyte0.89173361
83MP0005670_abnormal_white_adipose0.89106047
84MP0002970_abnormal_white_adipose0.88048593
85MP0001119_abnormal_female_reproductive0.87270028
86MP0003938_abnormal_ear_development0.86292642
87MP0000716_abnormal_immune_system0.85347024
88MP0004197_abnormal_fetal_growth/weight/0.84921516
89MP0002234_abnormal_pharynx_morphology0.84231359
90MP0002938_white_spotting0.81764947
91MP0004147_increased_porphyrin_level0.81423850
92MP0005499_abnormal_olfactory_system0.79756458
93MP0005394_taste/olfaction_phenotype0.79756458
94MP0001764_abnormal_homeostasis0.79047646
95MP0002163_abnormal_gland_morphology0.78872546
96MP0003646_muscle_fatigue0.78354366
97MP0002653_abnormal_ependyma_morphology0.76910467
98MP0002095_abnormal_skin_pigmentation0.75599267
99MP0005384_cellular_phenotype0.74819388
100MP0000858_altered_metastatic_potential0.74182396
101MP0008260_abnormal_autophagy0.73107002
102MP0008872_abnormal_physiological_respon0.71635199
103MP0003221_abnormal_cardiomyocyte_apopto0.71334793
104MP0001986_abnormal_taste_sensitivity0.70935606
105MP0005645_abnormal_hypothalamus_physiol0.70711466
106MP0000477_abnormal_intestine_morphology0.70318277
107MP0002161_abnormal_fertility/fecundity0.70152994
108MP0005671_abnormal_response_to0.69081292
109MP0000685_abnormal_immune_system0.68255953
110MP0010030_abnormal_orbit_morphology0.67676083
111MP0003656_abnormal_erythrocyte_physiolo0.67485944
112MP0001853_heart_inflammation0.65672961
113MP0005174_abnormal_tail_pigmentation0.64987826
114MP0001919_abnormal_reproductive_system0.64318695
115MP0005332_abnormal_amino_acid0.63698849
116MP0002405_respiratory_system_inflammati0.63351491
117MP0006276_abnormal_autonomic_nervous0.62113589
118MP0000750_abnormal_muscle_regeneration0.61871474
119MP0005621_abnormal_cell_physiology0.61652629
120MP0000015_abnormal_ear_pigmentation0.61606289
121MP0009931_abnormal_skin_appearance0.59999835
122MP0001800_abnormal_humoral_immune0.58528394
123MP0002420_abnormal_adaptive_immunity0.58428907
124MP0001873_stomach_inflammation0.57804137
125MP0003866_abnormal_defecation0.57244636
126MP0001819_abnormal_immune_cell0.57142301
127MP0005310_abnormal_salivary_gland0.56576520
128MP0005395_other_phenotype0.55891844
129MP0002098_abnormal_vibrissa_morphology0.55687815
130MP0003121_genomic_imprinting0.55669652
131MP0008770_decreased_survivor_rate0.55015028
132MP0005266_abnormal_metabolism0.54742980
133MP0003699_abnormal_female_reproductive0.53757201
134MP0010155_abnormal_intestine_physiology0.52753822
135MP0000465_gastrointestinal_hemorrhage0.52368701
136MP0001529_abnormal_vocalization0.52152955
137MP0001835_abnormal_antigen_presentation0.51127308
138MP0002111_abnormal_tail_morphology0.48436021

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.89983330
2Abnormal number of erythroid precursors (HP:0012131)5.71172299
3Birth length less than 3rd percentile (HP:0003561)5.70333869
4Reticulocytopenia (HP:0001896)5.23446468
5Oral leukoplakia (HP:0002745)4.51859127
6Abnormal mitochondria in muscle tissue (HP:0008316)4.43868503
7Acute necrotizing encephalopathy (HP:0006965)4.30755397
8Breast hypoplasia (HP:0003187)4.20195535
9Aplastic anemia (HP:0001915)3.92967171
10Acute encephalopathy (HP:0006846)3.91157917
11Rough bone trabeculation (HP:0100670)3.64086983
12Macrocytic anemia (HP:0001972)3.62142955
13Carpal bone hypoplasia (HP:0001498)3.58839091
14Cerebral hypomyelination (HP:0006808)3.55378352
15Pallor (HP:0000980)3.52462706
16Colon cancer (HP:0003003)3.48647465
17Increased intramyocellular lipid droplets (HP:0012240)3.42985025
18Abnormality of the anterior horn cell (HP:0006802)3.41911365
19Degeneration of anterior horn cells (HP:0002398)3.41911365
20Progressive macrocephaly (HP:0004481)3.24490643
21Lactic acidosis (HP:0003128)3.17550360
22Patellar aplasia (HP:0006443)3.15996745
23Increased muscle lipid content (HP:0009058)3.15802287
24Cerebral edema (HP:0002181)3.05799482
25Selective tooth agenesis (HP:0001592)3.01834714
26Aplasia/Hypoplasia of the patella (HP:0006498)3.01657011
27Abnormality of the preputium (HP:0100587)3.00325082
28Microretrognathia (HP:0000308)2.95389783
29Absent thumb (HP:0009777)2.95213025
3011 pairs of ribs (HP:0000878)2.89269568
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89150713
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89150713
33Renal Fanconi syndrome (HP:0001994)2.88005205
34Testicular atrophy (HP:0000029)2.85527676
35Trismus (HP:0000211)2.79962179
36Multiple enchondromatosis (HP:0005701)2.79412913
37Thrombocytosis (HP:0001894)2.75779932
38Chromsome breakage (HP:0040012)2.74677716
39Premature graying of hair (HP:0002216)2.74415258
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73847563
41Abnormal protein N-linked glycosylation (HP:0012347)2.73847563
42Abnormal protein glycosylation (HP:0012346)2.73847563
43Abnormal glycosylation (HP:0012345)2.73847563
44Truncus arteriosus (HP:0001660)2.73838626
45Exercise intolerance (HP:0003546)2.73321895
46Premature ovarian failure (HP:0008209)2.70401238
47Secondary amenorrhea (HP:0000869)2.66877613
48Pancytopenia (HP:0001876)2.63730724
49Impulsivity (HP:0100710)2.63019896
50Abnormality of chromosome stability (HP:0003220)2.60940599
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59295717
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55925293
53Meckel diverticulum (HP:0002245)2.55073498
54Myelodysplasia (HP:0002863)2.54516534
55Abnormal trabecular bone morphology (HP:0100671)2.54309501
56Progressive microcephaly (HP:0000253)2.53074329
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52790151
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52109801
59Increased serum lactate (HP:0002151)2.50170304
60Cellular immunodeficiency (HP:0005374)2.47571880
61Absent radius (HP:0003974)2.47487942
62Poikiloderma (HP:0001029)2.44538944
63Bone marrow hypocellularity (HP:0005528)2.42830231
64Lipid accumulation in hepatocytes (HP:0006561)2.40969724
65Abnormality of the ileum (HP:0001549)2.40287283
66Progressive muscle weakness (HP:0003323)2.39679846
67IgM deficiency (HP:0002850)2.39427793
68Cholecystitis (HP:0001082)2.38401410
69Abnormal gallbladder physiology (HP:0012438)2.38401410
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.35991140
71Increased hepatocellular lipid droplets (HP:0006565)2.35982822
72Respiratory difficulties (HP:0002880)2.34651409
73Exertional dyspnea (HP:0002875)2.33306570
743-Methylglutaconic aciduria (HP:0003535)2.32047637
75Type I transferrin isoform profile (HP:0003642)2.31824392
76Ragged-red muscle fibers (HP:0003200)2.31048168
77Aplasia involving forearm bones (HP:0009822)2.27563187
78Absent forearm bone (HP:0003953)2.27563187
79Sloping forehead (HP:0000340)2.25838637
80Hyperthyroidism (HP:0000836)2.25658471
81Abnormal spermatogenesis (HP:0008669)2.25437733
82Respiratory failure (HP:0002878)2.24620472
83Horseshoe kidney (HP:0000085)2.23026227
84Hypertensive crisis (HP:0100735)2.21921791
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21772312
86Hypoplasia of the radius (HP:0002984)2.20758035
87Cleft eyelid (HP:0000625)2.20493840
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.20286588
89Neoplasm of the pancreas (HP:0002894)2.17638858
90Seborrheic dermatitis (HP:0001051)2.17178453
91Microvesicular hepatic steatosis (HP:0001414)2.13716496
92Triphalangeal thumb (HP:0001199)2.12562906
93Emotional lability (HP:0000712)2.09989705
94Hepatocellular necrosis (HP:0001404)2.08990270
95CNS hypomyelination (HP:0003429)2.07739246
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07483285
97Abnormality of alanine metabolism (HP:0010916)2.07483285
98Hyperalaninemia (HP:0003348)2.07483285
99Increased CSF lactate (HP:0002490)2.07423007
100Opisthotonus (HP:0002179)2.07337391
101Muscle fiber atrophy (HP:0100295)2.06782538
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05438079
103Supernumerary spleens (HP:0009799)2.05218888
104Abnormal number of incisors (HP:0011064)2.05008045
105Ureteral duplication (HP:0000073)2.03953569
106Hypoplasia of the uterus (HP:0000013)2.01220863
107Type 2 muscle fiber atrophy (HP:0003554)1.97874584
108Medulloblastoma (HP:0002885)1.97106747
109Duplicated collecting system (HP:0000081)1.97009242
110Optic disc pallor (HP:0000543)1.96942354
111Redundant skin (HP:0001582)1.96517370
112Tracheoesophageal fistula (HP:0002575)1.95672913
113Aplasia/hypoplasia of the uterus (HP:0008684)1.95649973
114Duodenal stenosis (HP:0100867)1.95641660
115Small intestinal stenosis (HP:0012848)1.95641660
116Abnormality of glycolysis (HP:0004366)1.95447575
117Abnormality of reticulocytes (HP:0004312)1.94811053
118Lymphoma (HP:0002665)1.93232633
119Abnormality of the renal collecting system (HP:0004742)1.92662373
120Squamous cell carcinoma (HP:0002860)1.91398937
121Mitochondrial inheritance (HP:0001427)1.90670008
122Concave nail (HP:0001598)1.90271911
123Hepatic necrosis (HP:0002605)1.89253010
124Sparse eyelashes (HP:0000653)1.89124181
125Abnormal lung lobation (HP:0002101)1.87930940
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.86901318
127Slender long bone (HP:0003100)1.83962268
128Atresia of the external auditory canal (HP:0000413)1.82502282
129Poor head control (HP:0002421)1.82451659
130Methylmalonic aciduria (HP:0012120)1.82413026
131Pulmonary fibrosis (HP:0002206)1.82313371
132Entropion (HP:0000621)1.81755336
133Retinal dysplasia (HP:0007973)1.81573774
134Tongue fasciculations (HP:0001308)1.81553719
135Lethargy (HP:0001254)1.80943618
136Unsteady gait (HP:0002317)1.77329743
137Optic nerve coloboma (HP:0000588)1.76861999
138Reduced antithrombin III activity (HP:0001976)1.76755188
139Death in infancy (HP:0001522)1.76740883
140Rhabdomyosarcoma (HP:0002859)1.76594592
141Abnormality of DNA repair (HP:0003254)1.76382203
142Personality changes (HP:0000751)1.76345213
143CNS demyelination (HP:0007305)1.74797960
144Leukodystrophy (HP:0002415)1.74514552
145Abnormality of cochlea (HP:0000375)1.74442089
146Pendular nystagmus (HP:0012043)1.74416894
147Sclerocornea (HP:0000647)1.74382260
148Hypergonadotropic hypogonadism (HP:0000815)1.73478558
149Hypoplasia of the pons (HP:0012110)1.73055875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.29034026
2WEE14.37076681
3VRK23.98700879
4NME23.68716054
5EIF2AK13.34270725
6NEK22.79985776
7CDC72.78165738
8STK162.56706760
9DYRK32.35766283
10TTK2.32271085
11EIF2AK32.28711498
12TSSK62.23552522
13BRSK22.21786590
14VRK12.16215902
15SRPK12.08922999
16PLK42.06268584
17PLK11.99884568
18TLK11.88269109
19PASK1.87068718
20TESK21.73918593
21ACVR1B1.71913152
22PIM21.71036048
23BRSK11.63452780
24AURKB1.51997607
25ARAF1.49898946
26MAP2K71.48491145
27ATR1.48229269
28BRAF1.38533999
29CCNB11.38258846
30CDK71.35979734
31RPS6KA41.32793124
32SMG11.32596021
33MKNK11.30339146
34SCYL21.29727992
35AURKA1.23573350
36NEK11.23363899
37CHEK21.23199776
38RPS6KB21.22691622
39MAP3K81.19599931
40CDK81.17808024
41CDK41.14614417
42TRIB31.13710998
43MKNK21.13483246
44IRAK21.13480290
45PLK31.12744872
46MAP4K21.11376893
47STK101.05909264
48BCKDK1.03364266
49INSRR1.03264318
50MAP4K11.01956035
51PDK31.01711623
52PDK41.01711623
53CSNK1A1L1.01632464
54PAK41.00684928
55EEF2K1.00410751
56PIM10.88888797
57MST40.88653135
58ERN10.88004468
59CHEK10.85592265
60CLK10.84605775
61PRKD30.84572661
62IRAK10.81974870
63MAPK130.81448659
64MAP3K110.80568392
65NME10.79601220
66EIF2AK20.76439771
67DYRK20.74309446
68PAK10.73653147
69EPHA20.72533568
70IRAK30.72437508
71ZAK0.71678917
72TAOK20.71429389
73NUAK10.71017093
74MAPKAPK30.70921783
75CSNK2A10.70735157
76TESK10.69058623
77CSNK2A20.68167273
78ICK0.67972320
79CSNK1G10.64049389
80LRRK20.62983046
81TGFBR10.62955654
82CDK20.62859014
83PDK20.62265909
84ATM0.60644218
85LIMK10.59189855
86CSNK1G20.58877638
87GRK60.57921444
88KDR0.56988400
89PRKCI0.55847229
90CDK120.54407781
91STK40.54111753
92DAPK10.53580410
93MUSK0.52956069
94RAF10.52220356
95NLK0.49197583
96MOS0.47662435
97ZAP700.46979223
98TYK20.46144287
99MAP2K30.45990032
100CDK190.43662533
101RPS6KA50.43384390
102TEC0.43355895
103ABL20.43126169
104BLK0.41292234
105BTK0.36693364
106MAPKAPK50.36320497
107CDK10.35830134
108DAPK30.35409910
109PBK0.35289545
110TXK0.34892626
111IRAK40.33944408
112MELK0.32433640
113ALK0.32361028
114SIK10.32055785
115BMX0.31478121
116CSNK1G30.30145311
117ILK0.29642840
118TAF10.28127782
119AKT20.27683151
120PKN10.25975120
121PNCK0.25842993
122CDK11A0.25552866
123MAP3K10.25090545
124IKBKB0.24657876
125KIT0.23889202
126LATS20.23428322
127FLT30.21344111
128MAPK110.21306435
129MAP2K20.19801510
130CSNK1E0.17913568

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.19249122
2Ribosome_Homo sapiens_hsa030104.48659745
3Mismatch repair_Homo sapiens_hsa034304.13060612
4Proteasome_Homo sapiens_hsa030503.77854395
5RNA polymerase_Homo sapiens_hsa030203.70709422
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55347662
7Homologous recombination_Homo sapiens_hsa034403.22908939
8Base excision repair_Homo sapiens_hsa034103.20793402
9Spliceosome_Homo sapiens_hsa030403.02455182
10Nucleotide excision repair_Homo sapiens_hsa034202.98695300
11Pyrimidine metabolism_Homo sapiens_hsa002402.91936891
12RNA transport_Homo sapiens_hsa030132.87458720
13Cell cycle_Homo sapiens_hsa041102.36080331
14One carbon pool by folate_Homo sapiens_hsa006702.13040872
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03699273
16Fanconi anemia pathway_Homo sapiens_hsa034602.01139275
17Basal transcription factors_Homo sapiens_hsa030221.95524280
18RNA degradation_Homo sapiens_hsa030181.88537725
19Non-homologous end-joining_Homo sapiens_hsa034501.83880942
20Purine metabolism_Homo sapiens_hsa002301.64954758
21Vitamin B6 metabolism_Homo sapiens_hsa007501.47861800
22p53 signaling pathway_Homo sapiens_hsa041151.43604238
23Protein export_Homo sapiens_hsa030601.42250279
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32771282
25Folate biosynthesis_Homo sapiens_hsa007901.26184156
26mRNA surveillance pathway_Homo sapiens_hsa030151.21108819
27Huntingtons disease_Homo sapiens_hsa050161.12033544
28Epstein-Barr virus infection_Homo sapiens_hsa051691.10334522
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09323278
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08758737
31Sulfur relay system_Homo sapiens_hsa041221.06139088
32Pentose phosphate pathway_Homo sapiens_hsa000301.04772015
33Parkinsons disease_Homo sapiens_hsa050121.04108233
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.99666448
35Sulfur metabolism_Homo sapiens_hsa009200.96263440
36Oxidative phosphorylation_Homo sapiens_hsa001900.93046964
37Oocyte meiosis_Homo sapiens_hsa041140.79322322
38Antigen processing and presentation_Homo sapiens_hsa046120.78639894
39Systemic lupus erythematosus_Homo sapiens_hsa053220.78416658
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.76666876
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74644849
42Biosynthesis of amino acids_Homo sapiens_hsa012300.73561172
43Fatty acid elongation_Homo sapiens_hsa000620.73472685
44Herpes simplex infection_Homo sapiens_hsa051680.70143644
45Cardiac muscle contraction_Homo sapiens_hsa042600.68997219
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63791171
47Viral carcinogenesis_Homo sapiens_hsa052030.60979080
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60296484
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60067939
50Thyroid cancer_Homo sapiens_hsa052160.59622793
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56669756
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56312159
53Primary immunodeficiency_Homo sapiens_hsa053400.53667567
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.52307875
55Carbon metabolism_Homo sapiens_hsa012000.49539480
56N-Glycan biosynthesis_Homo sapiens_hsa005100.48623739
57Glutathione metabolism_Homo sapiens_hsa004800.47770978
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47730789
59HTLV-I infection_Homo sapiens_hsa051660.47137222
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43785048
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43189073
62Legionellosis_Homo sapiens_hsa051340.42913865
63Selenocompound metabolism_Homo sapiens_hsa004500.42766315
64Alzheimers disease_Homo sapiens_hsa050100.42652149
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42328736
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42159598
67Metabolic pathways_Homo sapiens_hsa011000.42069693
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41646676
69Fructose and mannose metabolism_Homo sapiens_hsa000510.41242874
70Steroid biosynthesis_Homo sapiens_hsa001000.41065423
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40717234
72Regulation of autophagy_Homo sapiens_hsa041400.36299370
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36136866
74Peroxisome_Homo sapiens_hsa041460.35919551
75Apoptosis_Homo sapiens_hsa042100.33042497
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.32858539
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32269272
78Vibrio cholerae infection_Homo sapiens_hsa051100.31661970
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30899977
80Collecting duct acid secretion_Homo sapiens_hsa049660.30214565
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.29717375
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28357337
83Galactose metabolism_Homo sapiens_hsa000520.28262970
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27757374
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26179133
86Measles_Homo sapiens_hsa051620.24697105
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24425314
88Small cell lung cancer_Homo sapiens_hsa052220.23332915
89Hepatitis B_Homo sapiens_hsa051610.23191059
90Lysine degradation_Homo sapiens_hsa003100.22472447
91Other glycan degradation_Homo sapiens_hsa005110.20522052
92Arachidonic acid metabolism_Homo sapiens_hsa005900.20082487
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20007096
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19421816
95Propanoate metabolism_Homo sapiens_hsa006400.19039443
96Colorectal cancer_Homo sapiens_hsa052100.18940719
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18461683
98Alcoholism_Homo sapiens_hsa050340.17382318
99Shigellosis_Homo sapiens_hsa051310.16467972
100Butanoate metabolism_Homo sapiens_hsa006500.16425604
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15770742
102Linoleic acid metabolism_Homo sapiens_hsa005910.15023812
103Bladder cancer_Homo sapiens_hsa052190.13178644
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13085471
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10869100
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.10149728
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08943109
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.08773443
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08671685
110Acute myeloid leukemia_Homo sapiens_hsa052210.07954321
111MicroRNAs in cancer_Homo sapiens_hsa052060.07832764
112Pyruvate metabolism_Homo sapiens_hsa006200.07384342
113Influenza A_Homo sapiens_hsa051640.06270594
114HIF-1 signaling pathway_Homo sapiens_hsa040660.06260861
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.06239369
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05466142
117Renin-angiotensin system_Homo sapiens_hsa046140.04555156
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.04046867
119Hematopoietic cell lineage_Homo sapiens_hsa046400.03011460
120Fatty acid metabolism_Homo sapiens_hsa012120.02699278
121Vitamin digestion and absorption_Homo sapiens_hsa049770.01952914
122Notch signaling pathway_Homo sapiens_hsa043300.00993702
123Phototransduction_Homo sapiens_hsa047440.00581883
124Arginine and proline metabolism_Homo sapiens_hsa003300.00435979
125Pathways in cancer_Homo sapiens_hsa05200-0.0086105

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