GNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoskeletal anchoring at plasma membrane (GO:0007016)4.21762156
2layer formation in cerebral cortex (GO:0021819)4.03180440
3negative regulation of cell size (GO:0045792)3.86604817
4positive regulation of Cdc42 GTPase activity (GO:0043089)3.78215138
5positive regulation by symbiont of host defense response (GO:0052509)3.71761228
6modulation by symbiont of host defense response (GO:0052031)3.71761228
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71761228
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71761228
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.71761228
10modulation by symbiont of host immune response (GO:0052553)3.71761228
11regulation of early endosome to late endosome transport (GO:2000641)3.64374399
12positive regulation of histone deacetylation (GO:0031065)3.62722139
13response to peptidoglycan (GO:0032494)3.62319808
14stress fiber assembly (GO:0043149)3.53204626
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39578299
16synaptic vesicle maturation (GO:0016188)3.32787731
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32340081
18barbed-end actin filament capping (GO:0051016)3.30807687
19protein localization to endosome (GO:0036010)3.27830111
20negative regulation of fatty acid transport (GO:2000192)3.22104328
21antigen processing and presentation of endogenous antigen (GO:0019883)3.20359269
22locomotory exploration behavior (GO:0035641)3.18076558
23regulation of ARF GTPase activity (GO:0032312)3.17766030
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.17641885
25detection of other organism (GO:0098543)3.11847115
26detection of bacterium (GO:0016045)3.11021594
27modulation by symbiont of host cellular process (GO:0044068)3.09839068
28semaphorin-plexin signaling pathway (GO:0071526)3.08267459
29apoptotic process involved in morphogenesis (GO:0060561)3.06633338
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04885585
31mannose metabolic process (GO:0006013)3.04771061
32sodium ion export (GO:0071436)3.03897471
33maternal placenta development (GO:0001893)3.01878613
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01107774
35activation of protein kinase A activity (GO:0034199)3.00337237
36cortical actin cytoskeleton organization (GO:0030866)2.98255348
37modulation by virus of host process (GO:0019054)2.96666340
38clathrin coat assembly (GO:0048268)2.95557484
39regulation of extracellular matrix disassembly (GO:0010715)2.93871221
40apoptotic cell clearance (GO:0043277)2.93559914
41leukocyte aggregation (GO:0070486)2.90932684
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88441947
43regulation of synapse structural plasticity (GO:0051823)2.88101048
44regulation of defense response to virus by virus (GO:0050690)2.87850786
45adherens junction assembly (GO:0034333)2.87180762
46activation of Rac GTPase activity (GO:0032863)2.86710847
47glucose 6-phosphate metabolic process (GO:0051156)2.85765646
48peptidyl-lysine dimethylation (GO:0018027)2.85303891
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84829408
50macrophage activation involved in immune response (GO:0002281)2.84595166
51cerebellar Purkinje cell layer development (GO:0021680)2.83405867
52establishment of nucleus localization (GO:0040023)2.82714329
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78200767
54positive regulation of nuclease activity (GO:0032075)2.76738907
553-UTR-mediated mRNA stabilization (GO:0070935)2.75336015
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74053380
57NIK/NF-kappaB signaling (GO:0038061)2.74038649
58glial cell proliferation (GO:0014009)2.73373349
59positive regulation of axon extension (GO:0045773)2.71707131
60regulation of ARF protein signal transduction (GO:0032012)2.70837034
61positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69340671
62regulation of leukocyte degranulation (GO:0043300)2.69220207
63receptor catabolic process (GO:0032801)2.68862732
64adenosine receptor signaling pathway (GO:0001973)2.68304209
65glucose catabolic process (GO:0006007)2.67552288
66neutrophil activation involved in immune response (GO:0002283)2.67265524
67negative regulation of cell killing (GO:0031342)2.66857770
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66857770
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65497894
70detection of external biotic stimulus (GO:0098581)2.65459973
71COPI coating of Golgi vesicle (GO:0048205)2.65056655
72Golgi transport vesicle coating (GO:0048200)2.65056655
73morphogenesis of an endothelium (GO:0003159)2.64563141
74endothelial tube morphogenesis (GO:0061154)2.64563141
75positive regulation of receptor recycling (GO:0001921)2.64404469
76regulation of T-helper 2 cell differentiation (GO:0045628)2.64282957
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62862580
78response to muramyl dipeptide (GO:0032495)2.62570777
79intracellular estrogen receptor signaling pathway (GO:0030520)2.61851436
80response to nerve growth factor (GO:1990089)2.61217104
81cellular response to nerve growth factor stimulus (GO:1990090)2.61217104
82positive regulation of nitric-oxide synthase activity (GO:0051000)2.60369135
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58650114
84protein retention in ER lumen (GO:0006621)2.57980046
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55834585
86amyloid precursor protein catabolic process (GO:0042987)2.55397955
87basement membrane organization (GO:0071711)2.53776676
88negative regulation of viral release from host cell (GO:1902187)2.53581225
89plasma membrane repair (GO:0001778)2.52967250
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52427004
91pentose-phosphate shunt (GO:0006098)2.51863788
92NADPH regeneration (GO:0006740)2.51699369
93pinocytosis (GO:0006907)2.49329900
94modulation by virus of host morphology or physiology (GO:0019048)2.49125241
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49066036
96positive regulation of protein dephosphorylation (GO:0035307)2.48701361
97protein heterotrimerization (GO:0070208)2.48269101
98activation of MAPKKK activity (GO:0000185)2.48175932
99negative regulation of catenin import into nucleus (GO:0035414)2.47594089
100cell-substrate junction assembly (GO:0007044)2.47320163
101signal complex assembly (GO:0007172)2.47043483
102dendritic spine morphogenesis (GO:0060997)2.46923505
103vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46466715
104cell-cell junction maintenance (GO:0045217)2.46429611
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.45515920
106ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.45233190
107positive regulation of glycogen biosynthetic process (GO:0045725)2.45033285
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44960946
109cortical cytoskeleton organization (GO:0030865)2.44877993
110protein targeting to plasma membrane (GO:0072661)2.44691564
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44127376
112actin filament bundle organization (GO:0061572)2.43973418
113actin filament bundle assembly (GO:0051017)2.43973418
114regulation of nuclease activity (GO:0032069)2.43967305
115positive regulation of lamellipodium organization (GO:1902745)2.43710266
116response to host (GO:0075136)2.43635028
117response to host defenses (GO:0052200)2.43635028
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43635028
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.42611349
120embryonic foregut morphogenesis (GO:0048617)2.42552043
121ectoderm development (GO:0007398)2.41724054
122regulation of interferon-beta biosynthetic process (GO:0045357)2.40047106
123positive regulation of gamma-delta T cell activation (GO:0046645)2.39679678
124regulation of mast cell degranulation (GO:0043304)2.39663204
125detection of molecule of bacterial origin (GO:0032490)2.38728215
126positive regulation of lamellipodium assembly (GO:0010592)2.38561308
127positive regulation of protein deacetylation (GO:0090312)2.38445958
128response to laminar fluid shear stress (GO:0034616)2.38168051
129positive thymic T cell selection (GO:0045059)2.35919288
130sexual reproduction (GO:0019953)2.35149567
131endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.35013900
132epithelial cell-cell adhesion (GO:0090136)2.34953432
133cell adhesion mediated by integrin (GO:0033627)2.33656006
134low-density lipoprotein particle clearance (GO:0034383)2.33538653
135cellular response to virus (GO:0098586)2.33399221
136endoplasmic reticulum unfolded protein response (GO:0030968)2.33326937
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33238252
138response to host immune response (GO:0052572)2.33238252
139positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32875164
140regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.32193398
141positive regulation of Rap GTPase activity (GO:0032854)2.31722821
142activation of JUN kinase activity (GO:0007257)2.31606710
143cell-substrate adherens junction assembly (GO:0007045)2.31595452
144focal adhesion assembly (GO:0048041)2.31595452
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.31326776
146negative regulation of microtubule polymerization (GO:0031115)2.30828148
147embryonic process involved in female pregnancy (GO:0060136)2.29715633
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29536179
149localization within membrane (GO:0051668)2.29028856
150regulation of regulated secretory pathway (GO:1903305)2.29023309
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28624928
152regulation of hippo signaling (GO:0035330)2.27910643
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27875986
154positive regulation of axonogenesis (GO:0050772)2.27802907
155regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.27647335
156detection of biotic stimulus (GO:0009595)2.26263884
157negative regulation of nucleotide catabolic process (GO:0030812)2.26071487
158negative regulation of erythrocyte differentiation (GO:0045647)2.25036488
159positive regulation of fibroblast migration (GO:0010763)2.24640075
160proline transport (GO:0015824)2.24560282
161germinal center formation (GO:0002467)2.24497907
162neuromuscular process controlling balance (GO:0050885)2.24074514
163regulation of lipid kinase activity (GO:0043550)2.23926426
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.23429196
165regulation of NFAT protein import into nucleus (GO:0051532)2.22755494
166regulation of fatty acid beta-oxidation (GO:0031998)2.22616333
167negative regulation of cardiac muscle tissue growth (GO:0055022)2.22574176
168negative regulation of heart growth (GO:0061117)2.22574176
169polarized epithelial cell differentiation (GO:0030859)2.21682446
170positive regulation of synapse maturation (GO:0090129)2.21014677
171regulation of p38MAPK cascade (GO:1900744)2.20964071
172cell communication by electrical coupling (GO:0010644)2.20778780
173endothelial cell chemotaxis (GO:0035767)2.19776409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13336632
2KDM2B_26808549_Chip-Seq_SUP-B15_Human2.87973516
3LXR_22292898_ChIP-Seq_THP-1_Human2.66782796
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.64812428
5* KDM2B_26808549_Chip-Seq_DND41_Human2.63829761
6MYC_22102868_ChIP-Seq_BL_Human2.61357371
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54359224
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.52154168
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.45809954
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.44570607
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27654163
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.27560640
13KDM2B_26808549_Chip-Seq_K562_Human2.24218880
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23271113
15* VDR_21846776_ChIP-Seq_THP-1_Human2.22427658
16* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06020287
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00630587
18RACK7_27058665_Chip-Seq_MCF-7_Human1.95865422
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95238572
20KDM2B_26808549_Chip-Seq_JURKAT_Human1.91300583
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90871125
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89411074
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89091264
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.81457531
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80963122
26CLOCK_20551151_ChIP-Seq_293T_Human1.77906480
27* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77352152
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76913901
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74875521
30ZNF263_19887448_ChIP-Seq_K562_Human1.72155616
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70178921
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64530652
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63002846
34* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59306275
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58326743
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57630983
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57508616
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52196481
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.48289929
40* RARB_27405468_Chip-Seq_BRAIN_Mouse1.48226685
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48154816
42* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47106586
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.45966242
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44640026
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43305915
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.43262756
47* CREB1_26743006_Chip-Seq_LNCaP_Human1.42230114
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41972573
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41791981
50* VDR_24763502_ChIP-Seq_THP-1_Human1.41206333
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41107550
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39940928
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39422471
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38967298
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37930911
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37153696
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36015761
58ATF3_27146783_Chip-Seq_COLON_Human1.35972693
59* MAF_26560356_Chip-Seq_TH1_Human1.35774083
60* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35608247
61* MAF_26560356_Chip-Seq_TH2_Human1.35239703
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35204162
63UTX_26944678_Chip-Seq_JUKART_Human1.34753402
64P68_20966046_ChIP-Seq_HELA_Human1.33675939
65SMC4_20622854_ChIP-Seq_HELA_Human1.30406182
66* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30111777
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30068694
68SPI1_23127762_ChIP-Seq_K562_Human1.30037267
69DROSHA_22980978_ChIP-Seq_HELA_Human1.28955740
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22966635
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.22402769
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22304916
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21905909
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20773759
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20600035
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20585273
77TP53_22127205_ChIP-Seq_IMR90_Human1.19186751
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18787354
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.18522376
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18272424
81GATA1_19941826_ChIP-Seq_K562_Human1.17091792
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14826774
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13130081
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11915304
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11500131
86* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11376740
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11327559
88* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10399027
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09914445
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09174685
91CTCF_27219007_Chip-Seq_Bcells_Human1.07699958
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07008332
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.06774253
94NCOR1_26117541_ChIP-Seq_K562_Human1.05132883
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04887348
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04722624
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04388144
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04343005
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03419022
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02258392
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.01745520
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01401533
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00611185
104* BCOR_27268052_Chip-Seq_Bcells_Human1.00545628
105TP63_22573176_ChIP-Seq_HFKS_Human1.00328456
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99330819
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98692015
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98573262
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.98492270
110RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97778885
111EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97778885
112SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97686605
113* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97612715
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97436037
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97304010
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97234635
117* BCL6_27268052_Chip-Seq_Bcells_Human0.97053589
118CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97005687
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.95972706
120* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95584545
121PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95393195
122* TET1_21451524_ChIP-Seq_MESCs_Mouse0.95265130
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.95100305
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94218216
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93526917
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.93479527
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93025875
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92731391
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92655757
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92108808
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.91652804
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.91652804
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91456293
134* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91291708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.50794763
2MP0003303_peritoneal_inflammation4.46639945
3MP0010234_abnormal_vibrissa_follicle3.44115036
4MP0005451_abnormal_body_composition3.08949430
5MP0003300_gastrointestinal_ulcer3.08680552
6MP0004859_abnormal_synaptic_plasticity2.93610718
7MP0004858_abnormal_nervous_system2.92860050
8MP0005076_abnormal_cell_differentiation2.91246947
9MP0009278_abnormal_bone_marrow2.90525264
10MP0008260_abnormal_autophagy2.77952518
11MP0008961_abnormal_basal_metabolism2.51299634
12MP0003283_abnormal_digestive_organ2.39586297
13MP0003566_abnormal_cell_adhesion2.12721511
14MP0005167_abnormal_blood-brain_barrier2.12571533
15MP0008438_abnormal_cutaneous_collagen2.12516874
16MP0002909_abnormal_adrenal_gland2.07192387
17MP0001849_ear_inflammation1.97978508
18MP0005623_abnormal_meninges_morphology1.96476270
19MP0002877_abnormal_melanocyte_morpholog1.95869792
20MP0000537_abnormal_urethra_morphology1.84926385
21MP0010352_gastrointestinal_tract_polyps1.82382092
22MP0003329_amyloid_beta_deposits1.72973275
23MP0001958_emphysema1.72966224
24MP0002419_abnormal_innate_immunity1.69439960
25MP0009780_abnormal_chondrocyte_physiolo1.68181792
26MP0004130_abnormal_muscle_cell1.67210823
27MP0005025_abnormal_response_to1.62890129
28MP0004510_myositis1.60982307
29MP0003075_altered_response_to1.58715177
30MP0003724_increased_susceptibility_to1.57645173
31MP0002234_abnormal_pharynx_morphology1.55566357
32MP0005409_darkened_coat_color1.55060295
33MP0000733_abnormal_muscle_development1.52233564
34MP0003091_abnormal_cell_migration1.49599576
35MP0004185_abnormal_adipocyte_glucose1.46593697
36MP0001348_abnormal_lacrimal_gland1.45011006
37MP0000678_abnormal_parathyroid_gland1.41707266
38MP0004272_abnormal_basement_membrane1.39565414
39MP0006054_spinal_hemorrhage1.39503221
40MP0003172_abnormal_lysosome_physiology1.39470974
41MP0009333_abnormal_splenocyte_physiolog1.38698583
42MP0005000_abnormal_immune_tolerance1.38363192
43MP0002089_abnormal_postnatal_growth/wei1.32719075
44MP0005275_abnormal_skin_tensile1.30545413
45MP0001835_abnormal_antigen_presentation1.30419037
46MP0001790_abnormal_immune_system1.30061277
47MP0005387_immune_system_phenotype1.30061277
48MP0003115_abnormal_respiratory_system1.24853796
49MP0010155_abnormal_intestine_physiology1.24841456
50MP0004381_abnormal_hair_follicle1.24238967
51MP0005501_abnormal_skin_physiology1.23352806
52MP0000013_abnormal_adipose_tissue1.21730396
53MP0003191_abnormal_cellular_cholesterol1.20202281
54MP0006082_CNS_inflammation1.19566248
55MP0000604_amyloidosis1.19500246
56MP0003279_aneurysm1.17908718
57MP0004264_abnormal_extraembryonic_tissu1.17904834
58MP0002653_abnormal_ependyma_morphology1.17746823
59MP0003183_abnormal_peptide_metabolism1.15993057
60MP0003045_fibrosis1.14956537
61MP0002420_abnormal_adaptive_immunity1.14699094
62MP0001819_abnormal_immune_cell1.14661284
63MP0000534_abnormal_ureter_morphology1.13966906
64MP0009785_altered_susceptibility_to1.12689951
65MP0003828_pulmonary_edema1.11145358
66MP0003763_abnormal_thymus_physiology1.10993625
67MP0002723_abnormal_immune_serum1.10678411
68MP0002060_abnormal_skin_morphology1.10645393
69MP0002452_abnormal_antigen_presenting1.10560136
70MP0000490_abnormal_crypts_of1.07098937
71MP0005023_abnormal_wound_healing1.06775675
72MP0005058_abnormal_lysosome_morphology1.06112965
73MP0002148_abnormal_hypersensitivity_rea1.05263916
74MP0004811_abnormal_neuron_physiology1.05221708
75MP0000003_abnormal_adipose_tissue1.04542256
76MP0002249_abnormal_larynx_morphology1.03609454
77MP0001800_abnormal_humoral_immune1.02374733
78MP0005390_skeleton_phenotype1.00147114
79MP0003635_abnormal_synaptic_transmissio0.99935358
80MP0004947_skin_inflammation0.98838961
81MP0005375_adipose_tissue_phenotype0.98546831
82MP0001873_stomach_inflammation0.97049410
83MP0009840_abnormal_foam_cell0.96503815
84MP0002896_abnormal_bone_mineralization0.95467584
85MP0005397_hematopoietic_system_phenotyp0.95281439
86MP0001545_abnormal_hematopoietic_system0.95281439
87MP0004233_abnormal_muscle_weight0.93324646
88MP0000750_abnormal_muscle_regeneration0.92917755
89MP0010030_abnormal_orbit_morphology0.92315973
90MP0000751_myopathy0.92176724
91MP0005464_abnormal_platelet_physiology0.91818915
92MP0001845_abnormal_inflammatory_respons0.88808818
93MP0000858_altered_metastatic_potential0.88211249
94MP0000569_abnormal_digit_pigmentation0.86390076
95MP0002398_abnormal_bone_marrow0.86362443
96MP0002405_respiratory_system_inflammati0.86255464
97MP0000343_altered_response_to0.85824520
98MP0003436_decreased_susceptibility_to0.85738743
99MP0009931_abnormal_skin_appearance0.85605809
100MP0004087_abnormal_muscle_fiber0.84958817
101MP0000716_abnormal_immune_system0.84862199
102MP0008770_decreased_survivor_rate0.83064021
103MP0005166_decreased_susceptibility_to0.83001531
104MP0001216_abnormal_epidermal_layer0.81538347
105MP0003453_abnormal_keratinocyte_physiol0.81482916
106MP0004808_abnormal_hematopoietic_stem0.81432240
107MP0005310_abnormal_salivary_gland0.81291281
108MP0002132_abnormal_respiratory_system0.80219910
109MP0008874_decreased_physiological_sensi0.79059528
110MP0005257_abnormal_intraocular_pressure0.78930739
111MP0000465_gastrointestinal_hemorrhage0.78463502
112MP0005621_abnormal_cell_physiology0.77413854
113MP0002429_abnormal_blood_cell0.77366676
114MP0005666_abnormal_adipose_tissue0.76454807
115MP0008469_abnormal_protein_level0.76197030
116MP0000685_abnormal_immune_system0.75398464
117MP0002925_abnormal_cardiovascular_devel0.74828966
118MP0000681_abnormal_thyroid_gland0.74776137
119MP0000767_abnormal_smooth_muscle0.74682875
120MP0003123_paternal_imprinting0.74477628
121MP0001851_eye_inflammation0.74114373
122MP0002063_abnormal_learning/memory/cond0.73789837
123MP0002722_abnormal_immune_system0.73266682
124MP0003448_altered_tumor_morphology0.72819632
125MP0004885_abnormal_endolymph0.72721029
126MP0010368_abnormal_lymphatic_system0.72082365
127MP0003122_maternal_imprinting0.71775530
128MP0001533_abnormal_skeleton_physiology0.71347401
129MP0009053_abnormal_anal_canal0.71059093
130MP0010630_abnormal_cardiac_muscle0.69905846
131MP0003119_abnormal_digestive_system0.69475226
132MP0002796_impaired_skin_barrier0.69319552
133MP0005248_abnormal_Harderian_gland0.68936730
134MP0000778_abnormal_nervous_system0.67707027
135MP0004197_abnormal_fetal_growth/weight/0.64709719
136MP0003942_abnormal_urinary_system0.63188537
137MP0005187_abnormal_penis_morphology0.62579450
138MP0003866_abnormal_defecation0.61978530
139MP0002733_abnormal_thermal_nociception0.61535299
140MP0002998_abnormal_bone_remodeling0.61299070
141MP0000955_abnormal_spinal_cord0.59068223
142MP0000747_muscle_weakness0.59016220
143MP0001614_abnormal_blood_vessel0.58835614
144MP0002128_abnormal_blood_circulation0.58440538
145MP0003385_abnormal_body_wall0.58230824
146MP0001915_intracranial_hemorrhage0.57941132
147MP0003634_abnormal_glial_cell0.56803281
148MP0002282_abnormal_trachea_morphology0.56412073
149MP0000467_abnormal_esophagus_morphology0.55919839
150MP0000477_abnormal_intestine_morphology0.55543604
151MP0000759_abnormal_skeletal_muscle0.55273614

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.15072744
2Cerebral aneurysm (HP:0004944)3.62747052
3Eczematoid dermatitis (HP:0000976)3.57109087
4Insomnia (HP:0100785)3.10319775
5Protrusio acetabuli (HP:0003179)3.04400911
6Shallow orbits (HP:0000586)3.01185791
7Distal upper limb amyotrophy (HP:0007149)2.99052868
8Upper limb amyotrophy (HP:0009129)2.99052868
9Abnormality of macrophages (HP:0004311)2.93517411
10Vertebral compression fractures (HP:0002953)2.83133894
11Elfin facies (HP:0004428)2.76150301
12Distal lower limb muscle weakness (HP:0009053)2.75448729
13Hand muscle atrophy (HP:0009130)2.74267573
14Recurrent abscess formation (HP:0002722)2.69343423
15Cellulitis (HP:0100658)2.64982143
16Bladder diverticulum (HP:0000015)2.62934005
17Lymphangioma (HP:0100764)2.62640762
18Renal duplication (HP:0000075)2.57198844
19Enlarged penis (HP:0000040)2.53097302
20Broad face (HP:0000283)2.52641743
21Papilledema (HP:0001085)2.50814461
22Rectal prolapse (HP:0002035)2.48390220
23Recurrent bacterial skin infections (HP:0005406)2.48192500
24Overriding aorta (HP:0002623)2.47710564
25Hypercortisolism (HP:0001578)2.44933988
26Renovascular hypertension (HP:0100817)2.43519402
27Mitral valve prolapse (HP:0001634)2.43364187
28Supranuclear gaze palsy (HP:0000605)2.39225336
29Pointed chin (HP:0000307)2.38497265
30Obstructive sleep apnea (HP:0002870)2.37451706
31Distal lower limb amyotrophy (HP:0008944)2.37347175
32Abnormality of liposaccharide metabolism (HP:0010968)2.35521637
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.35521637
34Abnormality of glycolipid metabolism (HP:0010969)2.35521637
35Bowel diverticulosis (HP:0005222)2.35502770
36Apathy (HP:0000741)2.31805765
37Achilles tendon contracture (HP:0001771)2.31559826
38J-shaped sella turcica (HP:0002680)2.31419807
39Increased IgE level (HP:0003212)2.28589454
40Genu recurvatum (HP:0002816)2.27541352
41Macroorchidism (HP:0000053)2.26465208
42Dilatation of the ascending aorta (HP:0005111)2.23371473
43Peritonitis (HP:0002586)2.22889036
44Diminished motivation (HP:0000745)2.22042452
45Hallux valgus (HP:0001822)2.21117352
46Ankle contracture (HP:0006466)2.21099054
47Deviation of the hallux (HP:0010051)2.19760358
48Premature rupture of membranes (HP:0001788)2.19225178
49Hyperparathyroidism (HP:0000843)2.16786063
50Aneurysm (HP:0002617)2.16637047
51Axonal loss (HP:0003447)2.16569567
52Hemorrhage of the eye (HP:0011885)2.16255308
53Flat acetabular roof (HP:0003180)2.15211863
54Broad metatarsal (HP:0001783)2.14703241
55Abnormality of the lower motor neuron (HP:0002366)2.14149178
56Ankyloglossia (HP:0010296)2.14018164
57Thin bony cortex (HP:0002753)2.13131132
58Long palpebral fissure (HP:0000637)2.13068598
59Obstructive lung disease (HP:0006536)2.11291789
60Chronic obstructive pulmonary disease (HP:0006510)2.11291789
61Striae distensae (HP:0001065)2.10588678
62Abnormality of the Achilles tendon (HP:0005109)2.10187702
63Myositis (HP:0100614)2.07295575
64Abnormality of the nasal mucosa (HP:0000433)2.06829296
65Aortic aneurysm (HP:0004942)2.06661330
66Long toe (HP:0010511)2.05682722
67Loss of speech (HP:0002371)2.05566525
68Subacute progressive viral hepatitis (HP:0006572)2.04900005
69Gingivitis (HP:0000230)2.04674592
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.04382689
71Flat cornea (HP:0007720)2.01631515
72Buphthalmos (HP:0000557)2.00747474
73Segmental peripheral demyelination/remyelination (HP:0003481)1.99098664
74Abnormality of oral frenula (HP:0000190)1.98540820
75Abnormal gallbladder physiology (HP:0012438)1.95961316
76Cholecystitis (HP:0001082)1.95961316
77Increased density of long bones (HP:0006392)1.95941115
78Recurrent gram-negative bacterial infections (HP:0005420)1.94434198
79Abnormality of the distal phalanges of the toes (HP:0010182)1.94426106
80Interstitial pulmonary disease (HP:0006530)1.94361570
81Cerebral inclusion bodies (HP:0100314)1.94359155
82Blue sclerae (HP:0000592)1.94291755
83Stridor (HP:0010307)1.94199194
84Neoplasm of the heart (HP:0100544)1.94167171
85Aortic dissection (HP:0002647)1.93492895
86Increased neuronal autofluorescent lipopigment (HP:0002074)1.93297688
87Bronchomalacia (HP:0002780)1.92294471
88Orchitis (HP:0100796)1.91050462
89Hypoventilation (HP:0002791)1.90541624
90Myokymia (HP:0002411)1.90501445
91Polygenic inheritance (HP:0010982)1.90459653
92Abnormality of polysaccharide metabolism (HP:0011012)1.90411915
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90411915
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90411915
95Rapidly progressive (HP:0003678)1.89884292
96Increased variability in muscle fiber diameter (HP:0003557)1.89224345
97Ulnar bowing (HP:0003031)1.88586917
98Mitral regurgitation (HP:0001653)1.87616774
99Atrophic scars (HP:0001075)1.84164329
100Polycythemia (HP:0001901)1.80294743
101Annular pancreas (HP:0001734)1.79871166
102Increased cerebral lipofuscin (HP:0011813)1.79563487
103Metaphyseal cupping (HP:0003021)1.79228703
104Turricephaly (HP:0000262)1.79176622
105Mediastinal lymphadenopathy (HP:0100721)1.78909828
106Amyloidosis (HP:0011034)1.78852809
107Growth hormone excess (HP:0000845)1.78223797
108Visceral angiomatosis (HP:0100761)1.77393906
109Pathologic fracture (HP:0002756)1.77118147
110Hypertensive crisis (HP:0100735)1.76863521
111Emphysema (HP:0002097)1.76461120
112Gastrointestinal infarctions (HP:0005244)1.76047805
113Nasal polyposis (HP:0100582)1.75586777
114Germ cell neoplasia (HP:0100728)1.75251414
115Hematochezia (HP:0002573)1.75190052
116Abnormality of the thoracic spine (HP:0100711)1.74563421
117Fibroma (HP:0010614)1.74136469
118Asymmetry of the thorax (HP:0001555)1.73993997
119Mildly elevated creatine phosphokinase (HP:0008180)1.73159217
120Amyotrophic lateral sclerosis (HP:0007354)1.72382675
121Easy fatigability (HP:0003388)1.71836240
122Neuronal loss in central nervous system (HP:0002529)1.70942426
123Urticaria (HP:0001025)1.70619333
124Difficulty climbing stairs (HP:0003551)1.70217002
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69574926
126Biconcave vertebral bodies (HP:0004586)1.69573294
127Bone pain (HP:0002653)1.68940184
128Congenital glaucoma (HP:0001087)1.68902680
129Large eyes (HP:0001090)1.68625220
130Fragile skin (HP:0001030)1.68412107
131Precocious puberty (HP:0000826)1.68118782
132Dysostosis multiplex (HP:0000943)1.67777320
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67696890
134Megalencephaly (HP:0001355)1.67572854
135Hypertriglyceridemia (HP:0002155)1.67470440
136Purpura (HP:0000979)1.67335666
137Hemangiomatosis (HP:0007461)1.67140768
138Back pain (HP:0003418)1.66596446
139Difficulty running (HP:0009046)1.66476820
140Urinary glycosaminoglycan excretion (HP:0003541)1.66471138
141Mucopolysacchariduria (HP:0008155)1.66471138
142Spinal rigidity (HP:0003306)1.66426031
143Gastrointestinal inflammation (HP:0004386)1.66395075
144Bulbar palsy (HP:0001283)1.66340726
145Myopathic facies (HP:0002058)1.66206298
146Ankle clonus (HP:0011448)1.66095385
147Short 4th metacarpal (HP:0010044)1.65975773
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65975773
149Reticulocytosis (HP:0001923)1.65830569
150Lower limb amyotrophy (HP:0007210)1.65051829
151Abnormality of skeletal muscle fiber size (HP:0012084)1.65037428
152Hamartoma of the eye (HP:0010568)1.63748653
153Disproportionate tall stature (HP:0001519)1.63456431
154Cervical subluxation (HP:0003308)1.62741244
155Fibrous tissue neoplasm (HP:0012316)1.62510842
156Increased connective tissue (HP:0009025)1.62207093
157Arnold-Chiari malformation (HP:0002308)1.61192210
158Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.60244108
159Frequent falls (HP:0002359)1.59613393
160Deep palmar crease (HP:0006191)1.59246564
161Scapular winging (HP:0003691)1.59098720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.67331782
2PKN24.07245298
3SMG13.11009597
4PRPF4B2.99328821
5EEF2K2.82923782
6ERN12.80300563
7IRAK32.53427128
8MAP3K102.51064498
9RIPK12.37761483
10MAP3K92.22260302
11KSR22.09389720
12PTK62.06352717
13EPHA22.04516891
14RIPK41.92116093
15PDGFRA1.87537383
16ICK1.76921323
17LRRK21.74171069
18NME21.71022894
19TYRO31.70195325
20MARK11.66467268
21TAOK11.63803937
22SCYL21.63276786
23PRKD31.62733984
24TAOK21.62520765
25IRAK41.62520341
26CAMKK11.61580562
27TTN1.61387514
28MAP3K31.52380174
29SIK21.46312689
30PAK41.39447393
31PAK61.38893021
32EPHB21.37183737
33ALK1.36289867
34RET1.36234603
35DAPK21.36134854
36BMX1.35784363
37TESK11.28293401
38EPHB11.25294671
39PTK21.24164504
40ARAF1.23354339
41DDR21.21170967
42SIK11.16761079
43KSR11.12915675
44TYK21.11943108
45NTRK11.10651766
46MAP3K131.10054527
47TNK21.09485076
48MAP3K21.07178085
49CDK121.06252810
50ILK1.04157926
51LATS20.99835647
52MINK10.97298181
53SIK30.97043478
54IRAK20.95878811
55DMPK0.94671003
56RPS6KA20.93756617
57PRKCH0.91537130
58MAP4K10.89639888
59LIMK10.88285239
60CAMK1G0.83783682
61PAK20.83184265
62CAMK1D0.82923750
63LMTK20.78785319
64FGFR40.78233369
65GRK60.75985255
66MAPKAPK30.75138220
67DAPK30.72757922
68TESK20.71551489
69MARK20.71221074
70RPS6KC10.71147738
71RPS6KL10.71147738
72RPS6KB20.70950020
73STK100.70865438
74MAP3K60.69817899
75MAP3K140.69724916
76PDGFRB0.67857103
77TGFBR20.67759971
78MST1R0.65554105
79JAK30.65417155
80PIM20.65397463
81DYRK1B0.64905021
82MAP3K10.64419342
83BRAF0.63644125
84TBK10.63489439
85UHMK10.62915659
86MTOR0.62103639
87MAP3K70.61093405
88FES0.60216557
89STK110.60033902
90MAP2K20.59494979
91CDK50.58723885
92NTRK20.57272620
93MAP3K110.56693704
94PDPK10.55788153
95HCK0.54903317
96MAP2K10.54783698
97STK380.54514139
98FER0.54196675
99PRKD20.53729465
100PRKD10.53436545
101CDC42BPA0.52346725
102BTK0.51877725
103FYN0.51066978
104PAK30.51045121
105CSF1R0.50480795
106MOS0.50267008
107CDK150.49991306
108MAP3K80.49979714
109NEK10.49772370
110CDK140.49562516
111RPS6KA60.48633479
112CSK0.47592825
113MAPKAPK20.47571060
114HIPK20.47375780
115JAK20.47244604
116FGR0.46237622
117CDK180.45899247
118ZAP700.45178085
119PDK10.44744532
120BLK0.44660326
121FGFR10.44583073
122CDK11A0.44428194
123ERBB20.44302416
124MATK0.44252665
125PTK2B0.43741486
126MAP2K30.43673786
127RPS6KA10.42923225
128SRC0.42767558
129PRKCZ0.42592731
130PRKG20.42427346
131MAPK120.42209259
132PHKG20.41521724
133PHKG10.41521724
134MAPK110.39509196
135IKBKE0.35122721
136KDR0.33166352
137CDK70.32850858
138PRKCI0.31494376
139JAK10.30255395

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59895587
2Other glycan degradation_Homo sapiens_hsa005112.36872823
3Chronic myeloid leukemia_Homo sapiens_hsa052201.88625303
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83663163
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.73282530
6VEGF signaling pathway_Homo sapiens_hsa043701.71835771
7Glioma_Homo sapiens_hsa052141.66111459
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59722154
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53548477
10Neurotrophin signaling pathway_Homo sapiens_hsa047221.50010668
11Non-small cell lung cancer_Homo sapiens_hsa052231.48564977
12Endometrial cancer_Homo sapiens_hsa052131.46595096
13Bladder cancer_Homo sapiens_hsa052191.44843035
14mTOR signaling pathway_Homo sapiens_hsa041501.39279160
15Pentose phosphate pathway_Homo sapiens_hsa000301.37938365
16Estrogen signaling pathway_Homo sapiens_hsa049151.36063209
17Renal cell carcinoma_Homo sapiens_hsa052111.31450956
18Focal adhesion_Homo sapiens_hsa045101.31210550
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31113829
20Proteoglycans in cancer_Homo sapiens_hsa052051.27674336
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27455787
22Pancreatic cancer_Homo sapiens_hsa052121.26188792
23Hepatitis C_Homo sapiens_hsa051601.25436215
24Fructose and mannose metabolism_Homo sapiens_hsa000511.24507606
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24243064
26B cell receptor signaling pathway_Homo sapiens_hsa046621.21602409
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21197410
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20968786
29Gap junction_Homo sapiens_hsa045401.20262785
30Notch signaling pathway_Homo sapiens_hsa043301.17138203
31Colorectal cancer_Homo sapiens_hsa052101.16957620
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.16699056
33Platelet activation_Homo sapiens_hsa046111.13734256
34Vibrio cholerae infection_Homo sapiens_hsa051101.11741723
35Endocytosis_Homo sapiens_hsa041441.11162736
36Nitrogen metabolism_Homo sapiens_hsa009101.10852319
37Gastric acid secretion_Homo sapiens_hsa049711.10537070
38TNF signaling pathway_Homo sapiens_hsa046681.09779551
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.09562900
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09342240
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09081289
42GnRH signaling pathway_Homo sapiens_hsa049121.08430663
43Amoebiasis_Homo sapiens_hsa051461.06914395
44Hepatitis B_Homo sapiens_hsa051611.05417753
45Galactose metabolism_Homo sapiens_hsa000521.05347595
46Malaria_Homo sapiens_hsa051441.04668995
47Influenza A_Homo sapiens_hsa051641.04265977
48Apoptosis_Homo sapiens_hsa042101.03913462
49Axon guidance_Homo sapiens_hsa043601.03717895
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.02732082
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01953460
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99657134
53Type II diabetes mellitus_Homo sapiens_hsa049300.98806626
54Dorso-ventral axis formation_Homo sapiens_hsa043200.98707385
55Osteoclast differentiation_Homo sapiens_hsa043800.98704602
56Acute myeloid leukemia_Homo sapiens_hsa052210.98359173
57Shigellosis_Homo sapiens_hsa051310.97605683
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96641172
59Insulin signaling pathway_Homo sapiens_hsa049100.96413476
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96090496
61Long-term potentiation_Homo sapiens_hsa047200.94872720
62Prolactin signaling pathway_Homo sapiens_hsa049170.93450568
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.92635921
64Oxytocin signaling pathway_Homo sapiens_hsa049210.92203909
65Rap1 signaling pathway_Homo sapiens_hsa040150.91906547
66Staphylococcus aureus infection_Homo sapiens_hsa051500.91395740
67ErbB signaling pathway_Homo sapiens_hsa040120.91385676
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90876193
69Toxoplasmosis_Homo sapiens_hsa051450.90795505
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90703894
71Insulin resistance_Homo sapiens_hsa049310.90566739
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89489241
73Phagosome_Homo sapiens_hsa041450.89376129
74Viral myocarditis_Homo sapiens_hsa054160.89296143
75Small cell lung cancer_Homo sapiens_hsa052220.88958683
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.88885360
77Synaptic vesicle cycle_Homo sapiens_hsa047210.88720697
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88052279
79T cell receptor signaling pathway_Homo sapiens_hsa046600.87714569
80Olfactory transduction_Homo sapiens_hsa047400.87683540
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86625088
82Cocaine addiction_Homo sapiens_hsa050300.86323737
83Leishmaniasis_Homo sapiens_hsa051400.86250621
84Adherens junction_Homo sapiens_hsa045200.85843484
85Salmonella infection_Homo sapiens_hsa051320.84156992
86Renin secretion_Homo sapiens_hsa049240.83358353
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83238521
88Thyroid cancer_Homo sapiens_hsa052160.82628151
89Hippo signaling pathway_Homo sapiens_hsa043900.82571366
90Melanogenesis_Homo sapiens_hsa049160.82524212
91Measles_Homo sapiens_hsa051620.81932361
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.81269662
93* Cholinergic synapse_Homo sapiens_hsa047250.79521179
94Salivary secretion_Homo sapiens_hsa049700.78991219
95* Dopaminergic synapse_Homo sapiens_hsa047280.77752947
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77254145
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.76101377
98* Chemokine signaling pathway_Homo sapiens_hsa040620.75920556
99ECM-receptor interaction_Homo sapiens_hsa045120.75806333
100AMPK signaling pathway_Homo sapiens_hsa041520.75571055
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74675229
102Prostate cancer_Homo sapiens_hsa052150.74464732
103MicroRNAs in cancer_Homo sapiens_hsa052060.73939530
104Dilated cardiomyopathy_Homo sapiens_hsa054140.73932397
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73650999
106Lysosome_Homo sapiens_hsa041420.73646161
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73584900
108Pertussis_Homo sapiens_hsa051330.73117394
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71505390
110HIF-1 signaling pathway_Homo sapiens_hsa040660.71101515
111Choline metabolism in cancer_Homo sapiens_hsa052310.71075272
112Tight junction_Homo sapiens_hsa045300.70722902
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70633317
114Viral carcinogenesis_Homo sapiens_hsa052030.69936404
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69855265
116Herpes simplex infection_Homo sapiens_hsa051680.69687993
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.68395240
118HTLV-I infection_Homo sapiens_hsa051660.67989612
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67910371
120Prion diseases_Homo sapiens_hsa050200.66483345
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66259999
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66141863
123Bile secretion_Homo sapiens_hsa049760.65094898
124Legionellosis_Homo sapiens_hsa051340.64406587
125Inositol phosphate metabolism_Homo sapiens_hsa005620.63971662
126Thyroid hormone synthesis_Homo sapiens_hsa049180.62890988
127MAPK signaling pathway_Homo sapiens_hsa040100.62835857
128Tuberculosis_Homo sapiens_hsa051520.62373936
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61718807
130Sulfur relay system_Homo sapiens_hsa041220.61472427
131* Circadian entrainment_Homo sapiens_hsa047130.60073222
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51962215
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51064937
134Epstein-Barr virus infection_Homo sapiens_hsa051690.49862848
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47043227

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