GNB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)8.96324662
2positive regulation of synapse maturation (GO:0090129)8.18120468
3urinary tract smooth muscle contraction (GO:0014848)7.43184256
4response to pheromone (GO:0019236)7.38952050
5potassium ion homeostasis (GO:0055075)6.99148950
6negative regulation of cytosolic calcium ion concentration (GO:0051481)6.94720290
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.89062050
8retinal cone cell development (GO:0046549)6.69106467
9regulation of synapse maturation (GO:0090128)6.38422021
10photoreceptor cell maintenance (GO:0045494)6.15894884
11positive regulation of dendritic spine morphogenesis (GO:0061003)6.12496550
12neurotransmitter-gated ion channel clustering (GO:0072578)6.04862299
13rhodopsin mediated signaling pathway (GO:0016056)6.02088835
14sodium ion export (GO:0071436)5.96985889
15eye photoreceptor cell development (GO:0042462)5.87047570
16photoreceptor cell development (GO:0042461)5.86708674
17gamma-aminobutyric acid signaling pathway (GO:0007214)5.71482174
18protein localization to synapse (GO:0035418)5.54112491
19synaptic vesicle exocytosis (GO:0016079)5.31308111
20protein-chromophore linkage (GO:0018298)5.16973390
21layer formation in cerebral cortex (GO:0021819)4.98231223
22synaptic vesicle endocytosis (GO:0048488)4.85473547
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81628451
24regulation of rhodopsin mediated signaling pathway (GO:0022400)4.77585500
25potassium ion export (GO:0071435)4.60416138
26sensory perception of light stimulus (GO:0050953)4.59925155
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.57606820
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.56890915
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49922716
30visual perception (GO:0007601)4.48078293
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.38424471
32positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.29001453
33regulation of synaptic vesicle exocytosis (GO:2000300)4.27437443
34positive regulation of CREB transcription factor activity (GO:0032793)4.26304242
35detection of visible light (GO:0009584)4.11892123
36positive regulation of gastrulation (GO:2000543)4.11442498
37positive regulation of TOR signaling (GO:0032008)4.09951659
38detection of light stimulus (GO:0009583)4.07270338
39nonmotile primary cilium assembly (GO:0035058)4.01265291
40relaxation of smooth muscle (GO:0044557)3.96123502
41postsynaptic membrane organization (GO:0001941)3.95317855
42cell communication by electrical coupling (GO:0010644)3.87099093
43mating behavior (GO:0007617)3.81214166
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80757777
45righting reflex (GO:0060013)3.78232126
46retina development in camera-type eye (GO:0060041)3.76736964
47cellular sodium ion homeostasis (GO:0006883)3.73551668
48regulation of voltage-gated calcium channel activity (GO:1901385)3.72424719
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71941828
50GMP metabolic process (GO:0046037)3.71783077
51presynaptic membrane assembly (GO:0097105)3.70998904
52regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.67948740
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.67948740
54striatum development (GO:0021756)3.67495457
55synaptic vesicle maturation (GO:0016188)3.65701105
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.55814964
57iron coordination entity transport (GO:1901678)3.54713593
58calcium ion import (GO:0070509)3.54308564
59axon cargo transport (GO:0008088)3.49760702
60positive regulation of cell cycle checkpoint (GO:1901978)3.46112921
61innervation (GO:0060384)3.44664916
62membrane repolarization (GO:0086009)3.40189437
63regulation of synaptic vesicle transport (GO:1902803)3.39374917
64negative regulation of astrocyte differentiation (GO:0048712)3.38163519
65membrane hyperpolarization (GO:0060081)3.35767652
66detection of temperature stimulus involved in sensory perception (GO:0050961)3.33960362
67detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.33960362
68cellular response to light stimulus (GO:0071482)3.28303477
69behavioral response to ethanol (GO:0048149)3.27518661
70anterograde axon cargo transport (GO:0008089)3.26286815
71establishment of synaptic vesicle localization (GO:0097480)3.25055471
72synaptic vesicle transport (GO:0048489)3.25055471
73drinking behavior (GO:0042756)3.24094937
74glycolytic process (GO:0006096)3.23257391
75regulation of NFAT protein import into nucleus (GO:0051532)3.19675271
76presynaptic membrane organization (GO:0097090)3.16775623
77phototransduction (GO:0007602)3.16449386
78neuron fate determination (GO:0048664)3.15736392
79substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.15093992
80substrate-independent telencephalic tangential migration (GO:0021826)3.15093992
81behavioral response to nicotine (GO:0035095)3.14221969
82positive regulation of dendritic spine development (GO:0060999)3.12504149
83photoreceptor cell differentiation (GO:0046530)3.10804337
84eye photoreceptor cell differentiation (GO:0001754)3.10804337
85spinal cord association neuron differentiation (GO:0021527)3.09341639
86detection of abiotic stimulus (GO:0009582)3.08626117
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.08270694
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08270694
89response to acidic pH (GO:0010447)3.05806788
90pyrimidine dimer repair (GO:0006290)3.04053491
91detection of external stimulus (GO:0009581)3.03901921
92glutamate receptor signaling pathway (GO:0007215)3.03827541
93midbrain development (GO:0030901)3.01755756
94regulation of neurotransmitter secretion (GO:0046928)3.00271893
95positive regulation of membrane potential (GO:0045838)2.96524903
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96485223
97potassium ion import (GO:0010107)2.96192322
98phototransduction, visible light (GO:0007603)2.96167163
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.94997588
100glutamate secretion (GO:0014047)2.92914814
101pre-miRNA processing (GO:0031054)2.92815216
102long-term memory (GO:0007616)2.92108685
103regulation of vesicle fusion (GO:0031338)2.90121366
104regulation of neurotransmitter transport (GO:0051588)2.89017245
105response to histamine (GO:0034776)2.88497710
106regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88307348
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.86413692
108primitive streak formation (GO:0090009)2.82697350
109regulation of bile acid biosynthetic process (GO:0070857)2.79786813
110membrane depolarization during action potential (GO:0086010)2.78876932
111dendritic spine morphogenesis (GO:0060997)2.76814212
112cerebral cortex radially oriented cell migration (GO:0021799)2.71933027
113pyrimidine nucleobase catabolic process (GO:0006208)2.70191496
114axonal fasciculation (GO:0007413)2.68176663
115central nervous system projection neuron axonogenesis (GO:0021952)2.64550446
116auditory behavior (GO:0031223)2.62730619
117cranial nerve morphogenesis (GO:0021602)2.62580863
118convergent extension (GO:0060026)2.60470718
119negative regulation of glial cell differentiation (GO:0045686)2.60010860
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55990470
121neuron recognition (GO:0008038)2.55051761
122cell migration in hindbrain (GO:0021535)2.53397322
123vocalization behavior (GO:0071625)2.53226916
124regulation of synapse structural plasticity (GO:0051823)2.52409232
125neuroblast proliferation (GO:0007405)2.49160299
126positive regulation of synapse assembly (GO:0051965)2.48377604
127negative regulation of DNA recombination (GO:0045910)2.48352578
128mechanosensory behavior (GO:0007638)2.48139031
129microtubule depolymerization (GO:0007019)2.48104333
130neuron cell-cell adhesion (GO:0007158)2.46707747
131retinal ganglion cell axon guidance (GO:0031290)2.45971663
132neuronal action potential propagation (GO:0019227)2.41969966
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39295206
134vitamin A metabolic process (GO:0006776)2.37350397
135exploration behavior (GO:0035640)2.36940616
136cranial nerve development (GO:0021545)2.33515562
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31695920
138regulation of mitotic spindle checkpoint (GO:1903504)2.31695920
139establishment of nucleus localization (GO:0040023)2.30909999
140sensory perception of taste (GO:0050909)2.29884631
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.29726682
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.27631091
143negative regulation of hormone biosynthetic process (GO:0032353)2.27413783
144hindbrain development (GO:0030902)2.26744629
145paraxial mesoderm development (GO:0048339)2.25824044
146regulation of helicase activity (GO:0051095)2.22964775
147locomotory exploration behavior (GO:0035641)2.22105232
148spinal cord development (GO:0021510)2.18111296
149cartilage condensation (GO:0001502)2.18048740
150cell aggregation (GO:0098743)2.18048740
151pituitary gland development (GO:0021983)2.16398687
152regulation of mitotic spindle organization (GO:0060236)2.15785221
153neuromuscular synaptic transmission (GO:0007274)2.15723970
154cell differentiation in spinal cord (GO:0021515)2.11345849
155regulation of synapse assembly (GO:0051963)2.11262004
156establishment of mitochondrion localization (GO:0051654)2.11041737
157negative regulation of DNA repair (GO:0045738)2.09923361
158axon extension involved in axon guidance (GO:0048846)2.08807807
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.08807807
160regulation of respiratory system process (GO:0044065)2.07405844
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.05717328
162mitochondrion transport along microtubule (GO:0047497)2.05717328
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.05311044
164detection of light stimulus involved in visual perception (GO:0050908)11.4846928
165detection of light stimulus involved in sensory perception (GO:0050962)11.4846928
166retinal rod cell development (GO:0046548)10.0095366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20653835
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.80032696
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.84777750
4GBX2_23144817_ChIP-Seq_PC3_Human3.79574128
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.64660611
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.27985044
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25607181
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.12905651
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.00860955
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.82132546
11REST_21632747_ChIP-Seq_MESCs_Mouse2.68058835
12AR_21572438_ChIP-Seq_LNCaP_Human2.60437273
13DROSHA_22980978_ChIP-Seq_HELA_Human2.56090582
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.53546473
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48826378
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.42146267
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36316488
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34304527
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25990426
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25357510
21P53_22127205_ChIP-Seq_FIBROBLAST_Human2.23066466
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21868371
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14822615
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.14649332
25E2F7_22180533_ChIP-Seq_HELA_Human2.11941451
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06987378
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.01374161
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01235115
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.98735846
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96053688
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93639473
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93639473
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.93336476
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.92888097
35TAF15_26573619_Chip-Seq_HEK293_Human1.87057818
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.82704604
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.79765875
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78520451
39CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.71378855
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71051536
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69284366
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.68200864
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65840934
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65795225
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60643597
46SMAD4_21799915_ChIP-Seq_A2780_Human1.57695018
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52651371
48FUS_26573619_Chip-Seq_HEK293_Human1.51600235
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48803491
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48060436
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47014000
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43763172
53AR_25329375_ChIP-Seq_VCAP_Human1.42024959
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41923393
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.38064260
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37646355
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37010815
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.36872049
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34369177
60STAT3_23295773_ChIP-Seq_U87_Human1.33829484
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33615916
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33446902
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.32479203
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31713742
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.30900583
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30505763
67VDR_22108803_ChIP-Seq_LS180_Human1.29888639
68EWS_26573619_Chip-Seq_HEK293_Human1.28275933
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.27431349
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.25494786
71CTCF_27219007_Chip-Seq_Bcells_Human1.25279588
72TCF4_23295773_ChIP-Seq_U87_Human1.24064052
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23944716
74P300_19829295_ChIP-Seq_ESCs_Human1.22541040
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.22322002
76AR_19668381_ChIP-Seq_PC3_Human1.21534492
77SOX9_26525672_Chip-Seq_HEART_Mouse1.20845740
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20250050
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18752867
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13893329
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.13807136
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12757442
83* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.12560870
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.12389437
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11817594
86BCAT_22108803_ChIP-Seq_LS180_Human1.10612163
87XRN2_22483619_ChIP-Seq_HELA_Human1.10523466
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09242507
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09158717
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.07930544
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06640193
92CBP_20019798_ChIP-Seq_JUKART_Human1.06640193
93CBP_21632823_ChIP-Seq_H3396_Human1.06533097
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06028247
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05888309
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05749381
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05616702
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05357245
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04650756
100TBL1_22424771_ChIP-Seq_293T_Human1.04386969
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04245968
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.03963423
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03814889
104PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02724637
105* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01892734
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00983806
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00983806
108ETV1_20927104_ChIP-Seq_GIST48_Human1.00338263
109RNF2_27304074_Chip-Seq_NSC_Mouse1.00275879
110CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00218719
111IGF1R_20145208_ChIP-Seq_DFB_Human0.99421892
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99225953
113THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97289594
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97274598
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96988039
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.96865727
117TCF4_22108803_ChIP-Seq_LS180_Human0.96280980
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95928288
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.95488587
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95421139
121E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95308266
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94676276
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.94557975
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93502216
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93225282
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93157711
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91854524
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90366460
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90319926
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89874457
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89417878
132ER_23166858_ChIP-Seq_MCF-7_Human0.89153456
133POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.88549903
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.88140780
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87774112
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87533185
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87251114
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86673450
139* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86273775
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85973003
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.83369589
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82988312
143NFYB_21822215_ChIP-Seq_K562_Human0.82757779
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82110610
145KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81376416
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80139109
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79031038
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77815919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.67823830
2MP0006072_abnormal_retinal_apoptosis5.20627156
3MP0001984_abnormal_olfaction4.99666275
4MP0002090_abnormal_vision4.43250256
5MP0005253_abnormal_eye_physiology4.13286270
6MP0003011_delayed_dark_adaptation3.62653621
7MP0010386_abnormal_urinary_bladder3.41625019
8MP0006292_abnormal_olfactory_placode3.28418107
9MP0005195_abnormal_posterior_eye2.98653856
10MP0003950_abnormal_plasma_membrane2.97371608
11MP0002638_abnormal_pupillary_reflex2.82539808
12MP0001502_abnormal_circadian_rhythm2.66866796
13MP0001986_abnormal_taste_sensitivity2.63790591
14MP0004233_abnormal_muscle_weight2.59813234
15MP0000566_synostosis2.35309753
16MP0005499_abnormal_olfactory_system2.25785467
17MP0005394_taste/olfaction_phenotype2.25785467
18MP0008789_abnormal_olfactory_epithelium2.22099391
19MP0002229_neurodegeneration2.13012231
20MP0003880_abnormal_central_pattern2.08273571
21MP0000778_abnormal_nervous_system2.01785609
22MP0009046_muscle_twitch1.97614670
23MP0010030_abnormal_orbit_morphology1.95203365
24MP0005391_vision/eye_phenotype1.94281009
25MP0001324_abnormal_eye_pigmentation1.88424172
26MP0004036_abnormal_muscle_relaxation1.80379367
27MP0002752_abnormal_somatic_nervous1.72861542
28MP0000049_abnormal_middle_ear1.69521212
29MP0005248_abnormal_Harderian_gland1.63641354
30MP0002734_abnormal_mechanical_nocicepti1.61267080
31MP0002272_abnormal_nervous_system1.58214383
32MP0002234_abnormal_pharynx_morphology1.57123433
33MP0002067_abnormal_sensory_capabilities1.56197324
34MP0005187_abnormal_penis_morphology1.54901942
35MP0003567_abnormal_fetal_cardiomyocyte1.52516526
36MP0003122_maternal_imprinting1.51914841
37MP0001529_abnormal_vocalization1.50815554
38MP0001346_abnormal_lacrimal_gland1.50740893
39MP0005423_abnormal_somatic_nervous1.50648500
40MP0002184_abnormal_innervation1.50156005
41MP0003879_abnormal_hair_cell1.49851665
42MP0003635_abnormal_synaptic_transmissio1.49319391
43MP0003868_abnormal_feces_composition1.46251930
44MP0004215_abnormal_myocardial_fiber1.45297109
45MP0001486_abnormal_startle_reflex1.43277565
46MP0002233_abnormal_nose_morphology1.39166077
47MP0002882_abnormal_neuron_morphology1.38979642
48MP0000537_abnormal_urethra_morphology1.37208447
49MP0004782_abnormal_surfactant_physiolog1.36557716
50MP0002938_white_spotting1.30948875
51MP0001968_abnormal_touch/_nociception1.30383070
52MP0002064_seizures1.29170744
53MP0002909_abnormal_adrenal_gland1.27456714
54MP0005670_abnormal_white_adipose1.26858199
55MP0001299_abnormal_eye_distance/1.25632029
56MP0004084_abnormal_cardiac_muscle1.23447015
57MP0002063_abnormal_learning/memory/cond1.21947015
58MP0004742_abnormal_vestibular_system1.20932397
59MP0005171_absent_coat_pigmentation1.20491709
60MP0005503_abnormal_tendon_morphology1.16493861
61MP0002653_abnormal_ependyma_morphology1.16036264
62MP0008569_lethality_at_weaning1.16019379
63MP0002822_catalepsy1.15043989
64MP0003890_abnormal_embryonic-extraembry1.14806825
65MP0001188_hyperpigmentation1.14182195
66MP0002735_abnormal_chemical_nociception1.13978599
67MP0003861_abnormal_nervous_system1.13210028
68MP0003935_abnormal_craniofacial_develop1.12303221
69MP0001293_anophthalmia1.11672505
70MP0002332_abnormal_exercise_endurance1.10980877
71MP0003938_abnormal_ear_development1.10340314
72MP0009745_abnormal_behavioral_response1.08299554
73MP0002102_abnormal_ear_morphology1.07869822
74MP0003755_abnormal_palate_morphology1.07703271
75MP0002249_abnormal_larynx_morphology1.07651692
76MP0003119_abnormal_digestive_system1.07202771
77MP0003937_abnormal_limbs/digits/tail_de1.06708781
78MP0002736_abnormal_nociception_after1.06339902
79MP0002277_abnormal_respiratory_mucosa1.06125436
80MP0001286_abnormal_eye_development1.05756604
81MP0004859_abnormal_synaptic_plasticity1.05529508
82MP0002152_abnormal_brain_morphology1.03492719
83MP0000751_myopathy1.01891393
84MP0009250_abnormal_appendicular_skeleto1.00412641
85MP0003136_yellow_coat_color1.00401321
86MP0008775_abnormal_heart_ventricle0.99002171
87MP0003283_abnormal_digestive_organ0.93365264
88MP0005595_abnormal_vascular_smooth0.92869204
89MP0002572_abnormal_emotion/affect_behav0.91160274
90MP0003942_abnormal_urinary_system0.90256703
91MP0000631_abnormal_neuroendocrine_gland0.88552141
92MP0003121_genomic_imprinting0.88458386
93MP0000428_abnormal_craniofacial_morphol0.87841312
94MP0010368_abnormal_lymphatic_system0.86437071
95MP0004145_abnormal_muscle_electrophysio0.86400874
96MP0004885_abnormal_endolymph0.85082587
97MP0002932_abnormal_joint_morphology0.84386325
98MP0002116_abnormal_craniofacial_bone0.82898186
99MP0003385_abnormal_body_wall0.82599860
100MP0002081_perinatal_lethality0.82179191
101MP0005620_abnormal_muscle_contractility0.76669671
102MP0008872_abnormal_physiological_respon0.76474495
103MP0004924_abnormal_behavior0.76197706
104MP0005386_behavior/neurological_phenoty0.76197706
105MP0004142_abnormal_muscle_tone0.76071729
106MP0000026_abnormal_inner_ear0.75888141
107MP0002089_abnormal_postnatal_growth/wei0.74480459
108MP0000955_abnormal_spinal_cord0.71823672
109MP0005220_abnormal_exocrine_pancreas0.71787163
110MP0001501_abnormal_sleep_pattern0.71659867
111MP0003634_abnormal_glial_cell0.71469715
112MP0008438_abnormal_cutaneous_collagen0.70844524
113MP0004811_abnormal_neuron_physiology0.69955128
114MP0004197_abnormal_fetal_growth/weight/0.69212048
115MP0002127_abnormal_cardiovascular_syste0.68376635
116MP0003115_abnormal_respiratory_system0.68204441
117MP0002092_abnormal_eye_morphology0.67813596
118MP0002085_abnormal_embryonic_tissue0.66871921
119MP0003111_abnormal_nucleus_morphology0.66673884
120MP0004085_abnormal_heartbeat0.66417266
121MP0005197_abnormal_uvea_morphology0.65416775
122MP0003183_abnormal_peptide_metabolism0.64965922
123MP0000569_abnormal_digit_pigmentation0.63270380
124MP0005623_abnormal_meninges_morphology0.63251764
125MP0004270_analgesia0.63085886
126MP0001963_abnormal_hearing_physiology0.62307187
127MP0008004_abnormal_stomach_pH0.60396014
128MP0002751_abnormal_autonomic_nervous0.59633683
129MP0006276_abnormal_autonomic_nervous0.57968597
130MP0002697_abnormal_eye_size0.56966896
131MP0001270_distended_abdomen0.56765241
132MP0002066_abnormal_motor_capabilities/c0.56764428
133MP0000534_abnormal_ureter_morphology0.55666306
134MP0002557_abnormal_social/conspecific_i0.53936231
135MP0009697_abnormal_copulation0.53347781
136MP0001970_abnormal_pain_threshold0.52653450
137MP0003787_abnormal_imprinting0.51541376
138MP0004043_abnormal_pH_regulation0.51531057
139MP0003633_abnormal_nervous_system0.49025843
140MP0001485_abnormal_pinna_reflex0.48519581
141MP0003137_abnormal_impulse_conducting0.46046816
142MP0006035_abnormal_mitochondrial_morpho0.45588599

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.81201954
2Abnormality of macular pigmentation (HP:0008002)7.95952479
3Severe visual impairment (HP:0001141)7.54737118
4Abnormal rod and cone electroretinograms (HP:0008323)7.39797465
5Decreased central vision (HP:0007663)6.52481355
6Scotoma (HP:0000575)6.19519790
7Bony spicule pigmentary retinopathy (HP:0007737)6.08933649
8Increased corneal curvature (HP:0100692)5.92695797
9Keratoconus (HP:0000563)5.92695797
10Absent rod-and cone-mediated responses on ERG (HP:0007688)5.41854561
11Dyschromatopsia (HP:0007641)5.30130979
12Intestinal atresia (HP:0011100)4.89771693
13Annular pancreas (HP:0001734)4.84205678
14Pendular nystagmus (HP:0012043)4.67486338
15Abolished electroretinogram (ERG) (HP:0000550)4.47863868
16Attenuation of retinal blood vessels (HP:0007843)4.06112252
17Pigmentary retinal degeneration (HP:0001146)4.04668528
18Septo-optic dysplasia (HP:0100842)3.99450822
19Abnormal gallbladder physiology (HP:0012438)3.95859583
20Cholecystitis (HP:0001082)3.95859583
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.94339645
22Esophageal atresia (HP:0002032)3.93826612
23Epileptic encephalopathy (HP:0200134)3.89146651
24Absence seizures (HP:0002121)3.75232171
25Chorioretinal atrophy (HP:0000533)3.67579115
26Polar cataract (HP:0010696)3.63488392
27Supernumerary spleens (HP:0009799)3.54167276
28Photophobia (HP:0000613)3.51461592
29Type II diabetes mellitus (HP:0005978)3.31261825
30Constricted visual fields (HP:0001133)3.24786915
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.19034243
32Hypoplasia of the fovea (HP:0007750)3.19034243
33Cone-rod dystrophy (HP:0000548)3.18316293
34Febrile seizures (HP:0002373)3.05170142
35Progressive cerebellar ataxia (HP:0002073)3.02714427
36Retinitis pigmentosa (HP:0000510)3.00730141
37Cerebellar dysplasia (HP:0007033)2.95048323
38Ependymoma (HP:0002888)2.92555113
39Dialeptic seizures (HP:0011146)2.90289578
40Depressed nasal tip (HP:0000437)2.90136306
41Macular degeneration (HP:0000608)2.78380731
42Abnormality of abdominal situs (HP:0011620)2.71220985
43Abdominal situs inversus (HP:0003363)2.71220985
44Abnormality of the fovea (HP:0000493)2.67624978
45Posterior subcapsular cataract (HP:0007787)2.66165170
46Abnormality of alanine metabolism (HP:0010916)2.62488880
47Hyperalaninemia (HP:0003348)2.62488880
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62488880
49Albinism (HP:0001022)2.54222544
50Aplasia/Hypoplasia of the macula (HP:0008059)2.54010155
51Gait imbalance (HP:0002141)2.53490291
52Dysdiadochokinesis (HP:0002075)2.53020324
53Choroideremia (HP:0001139)2.52253047
54Gastrointestinal atresia (HP:0002589)2.49689037
55Congenital sensorineural hearing impairment (HP:0008527)2.48405138
56Turricephaly (HP:0000262)2.48298428
57Astrocytoma (HP:0009592)2.46337700
58Abnormality of the astrocytes (HP:0100707)2.46337700
59Generalized tonic-clonic seizures (HP:0002069)2.44006992
60EEG with generalized epileptiform discharges (HP:0011198)2.43881497
61Congenital primary aphakia (HP:0007707)2.43500687
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.40419814
63Epileptiform EEG discharges (HP:0011182)2.33501403
64Abnormality of the 2nd finger (HP:0004100)2.28471557
65Medulloblastoma (HP:0002885)2.26897489
66Neoplasm of the oral cavity (HP:0100649)2.26679674
67Nephrogenic diabetes insipidus (HP:0009806)2.21918075
68Prolonged QT interval (HP:0001657)2.20665753
69Abnormal pupillary function (HP:0007686)2.18320223
70Vitreoretinal degeneration (HP:0000655)2.17213276
71Partial agenesis of the corpus callosum (HP:0001338)2.13314060
72Mutism (HP:0002300)2.13307526
73Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.12730173
74Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11617775
75Coronal craniosynostosis (HP:0004440)2.11193709
76Medial flaring of the eyebrow (HP:0010747)2.08694179
77Absent septum pellucidum (HP:0001331)2.01837641
78Congenital stationary night blindness (HP:0007642)15.0857631
79Exercise-induced myalgia (HP:0003738)1.99106005
80Optic disc pallor (HP:0000543)1.98726400
81Rhabdomyosarcoma (HP:0002859)1.98028439
82Focal seizures (HP:0007359)1.97965749
83Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96365518
84Retinal dysplasia (HP:0007973)1.89020504
85Optic nerve hypoplasia (HP:0000609)1.89017990
86Broad metatarsal (HP:0001783)1.87111081
87Depression (HP:0000716)1.86693642
88Astigmatism (HP:0000483)1.86193761
89Focal motor seizures (HP:0011153)1.82260094
90Abnormality of the septum pellucidum (HP:0007375)1.81285490
91Poor coordination (HP:0002370)1.79513579
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.79474611
93Rib fusion (HP:0000902)1.79386479
94Maternal diabetes (HP:0009800)1.78524590
95Agnosia (HP:0010524)1.77307050
96Neoplasm of striated muscle (HP:0009728)1.76518426
97Aplasia/Hypoplasia of the patella (HP:0006498)1.75140516
98Dysmetric saccades (HP:0000641)1.72978585
99Glioma (HP:0009733)1.72760601
100Heterotopia (HP:0002282)1.72358025
101Abnormality of the labia minora (HP:0012880)1.70711124
102Abnormality of the vocal cords (HP:0008777)1.70076026
103Abnormality of the phalanges of the 5th finger (HP:0004213)1.70004045
104Subcapsular cataract (HP:0000523)1.69975508
105Severe Myopia (HP:0011003)1.69474180
106Gaze-evoked nystagmus (HP:0000640)1.67910770
107Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67744249
108Aplasia/Hypoplasia of the lens (HP:0008063)1.66460186
109Type II lissencephaly (HP:0007260)1.65008972
110Ventricular fibrillation (HP:0001663)1.64575695
111Myokymia (HP:0002411)1.63586004
112Asplenia (HP:0001746)1.62625964
113Patellar aplasia (HP:0006443)1.61536223
114Hand muscle atrophy (HP:0009130)1.61519397
115True hermaphroditism (HP:0010459)1.61131395
116Hemiparesis (HP:0001269)1.60895433
1172-3 toe syndactyly (HP:0004691)1.60519299
118Vaginal atresia (HP:0000148)1.60448948
119Wide nasal bridge (HP:0000431)1.60358958
120Buphthalmos (HP:0000557)1.59500206
121Syncope (HP:0001279)1.58646062
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58410726
123Abnormality of the lower motor neuron (HP:0002366)1.58190720
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.57909837
125Chin dimple (HP:0010751)1.57519129
126Growth hormone deficiency (HP:0000824)1.57169285
127Genital tract atresia (HP:0001827)1.55476536
128Unsteady gait (HP:0002317)1.54968807
129Abnormal EKG (HP:0003115)1.53606003
130Midline defect of the nose (HP:0004122)1.53536450
131Broad distal phalanx of finger (HP:0009836)1.53271476
132Abnormality of dentin (HP:0010299)1.53209703
133Atonic seizures (HP:0010819)1.52889709
134Generalized hypopigmentation (HP:0007513)1.52590553
135Truncal ataxia (HP:0002078)1.51648397
136Atrial fibrillation (HP:0005110)1.51617690
137Supranuclear gaze palsy (HP:0000605)1.50669059
138Obsessive-compulsive behavior (HP:0000722)1.48573546
139Ulnar bowing (HP:0003031)1.48523384
140Bowel diverticulosis (HP:0005222)1.46562118
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.46461672
142Pancreatic fibrosis (HP:0100732)1.46066655
143Bilateral microphthalmos (HP:0007633)1.45873509
144Neoplasm of the heart (HP:0100544)1.45814189
145Abnormality of the 4th metacarpal (HP:0010012)1.44854499
146Alacrima (HP:0000522)1.43474914
147Left ventricular hypertrophy (HP:0001712)1.43148387
148Lissencephaly (HP:0001339)1.42227067
149Horizontal nystagmus (HP:0000666)1.42056382
150Cutaneous finger syndactyly (HP:0010554)1.41611038
151Widely spaced teeth (HP:0000687)1.41456584
152Anophthalmia (HP:0000528)1.40781054
153Short 4th metacarpal (HP:0010044)1.40516963
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.40516963
155Aqueductal stenosis (HP:0002410)1.40441181
156Broad-based gait (HP:0002136)1.38496313
157Cortical dysplasia (HP:0002539)1.38006469
158Amblyopia (HP:0000646)1.37991333
159Primary atrial arrhythmia (HP:0001692)1.36521057
160High anterior hairline (HP:0009890)1.35698303
161Ectopic kidney (HP:0000086)1.34667121
162Specific learning disability (HP:0001328)1.34414102
163Hepatoblastoma (HP:0002884)1.34089795
164Facial asymmetry (HP:0000324)1.34013729
165Decreased lacrimation (HP:0000633)1.33776486
166Abnormality of the antihelix (HP:0009738)1.33770586
167Oligodactyly (hands) (HP:0001180)1.32016940
168Narrow nasal bridge (HP:0000446)1.30772558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK9.24907891
2NEK14.10917030
3CASK3.36950291
4STK38L3.26175486
5NME13.10604456
6RIPK12.73014615
7PAK62.72435966
8FGFR22.67403179
9PRPF4B2.65488826
10PINK12.49722334
11MAP3K132.45798833
12STK382.34218554
13MAP4K22.19282169
14PNCK2.16338993
15TAOK22.14093672
16EPHB21.97840016
17EPHA31.92509457
18PHKG11.91469599
19PHKG21.91469599
20MAP3K101.86810166
21MINK11.83025117
22SRPK11.83022694
23MAP3K41.81040171
24NTRK31.73476000
25BUB11.71738582
26DYRK1A1.66613364
27UHMK11.65345421
28CDK31.64168803
29MARK11.61315324
30DYRK31.61064836
31FES1.60197677
32DYRK21.52437920
33INSRR1.52061940
34TLK11.51002902
35MAP3K71.50723499
36GRK11.44174028
37MAP2K71.40744255
38LMTK21.40603178
39WEE11.39938196
40NTRK11.37123069
41CDC71.36855432
42CAMK1D1.35826456
43CAMK2D1.29056205
44PDGFRA1.24900758
45PRKAA11.23604667
46EPHA41.22417904
47PASK1.20336821
48CCNB11.18876756
49ICK1.18108820
50SGK21.16656611
51DYRK1B1.16324945
52FER1.14236973
53WNK41.12679776
54MAPK151.11885640
55STK41.06280579
56KSR11.05932807
57PRKD21.03981025
58TRIB31.02660086
59CAMK1G1.02283212
60MKNK20.97546979
61WNK10.96172020
62IRAK20.92943459
63CLK10.92809957
64VRK10.90722634
65MTOR0.88997590
66MAP3K60.88286091
67PRKD30.87153522
68CDK120.86593600
69PKN20.85323813
70MKNK10.81978968
71PRKG20.81758416
72CAMK10.80681427
73AKT30.79490674
74PAK40.79133500
75BCR0.75688823
76CDK140.75666156
77ERBB20.72317162
78VRK20.71817616
79FGFR10.71396333
80IRAK10.71066527
81TNK20.70066671
82LATS20.68207676
83CHEK10.68116343
84CDK20.65920305
85PLK30.64157578
86MAP3K90.63676071
87PKN10.62616769
88SGK4940.61662596
89SGK2230.61662596
90BRSK10.60780453
91CSNK1D0.59538270
92PRKCE0.59053578
93ATR0.57446494
94MARK20.56943130
95PRKDC0.55953654
96BRD40.55421515
97RPS6KA40.55278167
98DMPK0.54727750
99RPS6KA20.54126226
100STK30.53337079
101CDK10.51419068
102MAPK70.51373268
103SGK30.51219690
104ATM0.49858646
105PLK40.49433498
106CDK150.49389589
107STK390.48901237
108PRKG10.48533926
109PAK30.47900331
110CAMK2A0.47539772
111ERBB30.47153016
112DAPK20.47070488
113NEK20.46168652
114PRKCZ0.45672290
115PLK10.45577245
116KSR20.45120966
117TTK0.44738852
118AURKB0.44663331
119PRKAA20.44630175
120CDK180.44321524
121AKT20.44321218
122MAP2K40.44162769
123PRKCA0.43666276
124STK110.43488844
125MAPK100.42260180
126CDK50.42219440
127CDK11A0.40130869
128PRKCB0.38234314
129CAMK40.37778417
130MAPK130.37628057
131GRK50.37462539
132PRKACA0.37280142
133TNIK0.36463288
134ROCK20.34891047
135RPS6KA30.34011179
136PRKCG0.33814618
137SIK20.33515604
138GSK3B0.32856973
139CAMKK10.32663320
140PRKCH0.30552727
141MAPK90.28943283
142MAPK120.28932655
143CHEK20.28719843
144RPS6KB20.27667451
145WNK30.26619412
146HIPK20.26184424
147RPS6KA50.24449083
148PRKACG0.23017369
149MAPK80.22821898
150ADRBK10.22209136
151MAPK140.21128951
152CAMKK20.20293462
153PRKACB0.19851821
154NTRK20.19643331
155CDC42BPA0.17832160
156FLT30.17685577
157MAPK10.16823004
158CSNK1E0.16591842

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.72927832
2Synaptic vesicle cycle_Homo sapiens_hsa047214.55990027
3Nicotine addiction_Homo sapiens_hsa050334.32248419
4* GABAergic synapse_Homo sapiens_hsa047273.70361121
5* Morphine addiction_Homo sapiens_hsa050323.16837918
6Circadian rhythm_Homo sapiens_hsa047102.89234128
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87915244
8Olfactory transduction_Homo sapiens_hsa047402.75890277
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.37496580
10Insulin secretion_Homo sapiens_hsa049112.24275007
11Renin secretion_Homo sapiens_hsa049242.14665045
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99735256
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.97665097
14Collecting duct acid secretion_Homo sapiens_hsa049661.92947512
15Fructose and mannose metabolism_Homo sapiens_hsa000511.88431005
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86383154
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80622791
18* Circadian entrainment_Homo sapiens_hsa047131.78318608
19Salivary secretion_Homo sapiens_hsa049701.76680672
20Basal cell carcinoma_Homo sapiens_hsa052171.74649478
21Cardiac muscle contraction_Homo sapiens_hsa042601.68602586
22Mismatch repair_Homo sapiens_hsa034301.66544027
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61447494
24Biosynthesis of amino acids_Homo sapiens_hsa012301.61205014
25Hedgehog signaling pathway_Homo sapiens_hsa043401.59036162
26Ribosome_Homo sapiens_hsa030101.45781369
27Dilated cardiomyopathy_Homo sapiens_hsa054141.44196610
28Oxytocin signaling pathway_Homo sapiens_hsa049211.40047514
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36570289
30* Glutamatergic synapse_Homo sapiens_hsa047241.36412197
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32658715
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31250959
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.30090784
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28865056
35* Cholinergic synapse_Homo sapiens_hsa047251.28304935
36mRNA surveillance pathway_Homo sapiens_hsa030151.25279631
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24699739
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21304185
39Fanconi anemia pathway_Homo sapiens_hsa034601.17196029
40Basal transcription factors_Homo sapiens_hsa030221.15695377
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14048775
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12441989
43Type II diabetes mellitus_Homo sapiens_hsa049301.11263387
44Calcium signaling pathway_Homo sapiens_hsa040201.08050792
45Melanogenesis_Homo sapiens_hsa049161.05550292
46Oocyte meiosis_Homo sapiens_hsa041141.05437973
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05377605
48RNA transport_Homo sapiens_hsa030131.04717621
49Hippo signaling pathway_Homo sapiens_hsa043901.04432946
50RNA polymerase_Homo sapiens_hsa030201.03816806
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.01569054
52Wnt signaling pathway_Homo sapiens_hsa043101.01456583
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99744585
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98178208
55* Serotonergic synapse_Homo sapiens_hsa047260.97476854
56Notch signaling pathway_Homo sapiens_hsa043300.96398758
57* Dopaminergic synapse_Homo sapiens_hsa047280.94335927
58Cell cycle_Homo sapiens_hsa041100.94080598
59Mineral absorption_Homo sapiens_hsa049780.94075328
60Non-homologous end-joining_Homo sapiens_hsa034500.93571114
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90766446
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87753518
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85341566
64Spliceosome_Homo sapiens_hsa030400.85269718
65* Taste transduction_Homo sapiens_hsa047420.84967429
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84763639
67RNA degradation_Homo sapiens_hsa030180.84155708
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.84149758
69Nucleotide excision repair_Homo sapiens_hsa034200.80953262
70Base excision repair_Homo sapiens_hsa034100.80593001
71Vibrio cholerae infection_Homo sapiens_hsa051100.79701674
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79661130
73Pancreatic secretion_Homo sapiens_hsa049720.76011890
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75648118
75Selenocompound metabolism_Homo sapiens_hsa004500.75249241
76ABC transporters_Homo sapiens_hsa020100.74825021
77Melanoma_Homo sapiens_hsa052180.74136553
78Gap junction_Homo sapiens_hsa045400.71922353
79Carbon metabolism_Homo sapiens_hsa012000.70937655
80Pentose phosphate pathway_Homo sapiens_hsa000300.69326852
81ErbB signaling pathway_Homo sapiens_hsa040120.68772340
82mTOR signaling pathway_Homo sapiens_hsa041500.68081108
83cAMP signaling pathway_Homo sapiens_hsa040240.67288908
84DNA replication_Homo sapiens_hsa030300.65920720
85TGF-beta signaling pathway_Homo sapiens_hsa043500.65903466
86Butanoate metabolism_Homo sapiens_hsa006500.65509370
87Huntingtons disease_Homo sapiens_hsa050160.64995998
88Bile secretion_Homo sapiens_hsa049760.63810016
89One carbon pool by folate_Homo sapiens_hsa006700.62591875
90Inositol phosphate metabolism_Homo sapiens_hsa005620.62322778
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62050479
92Gastric acid secretion_Homo sapiens_hsa049710.58841742
93Homologous recombination_Homo sapiens_hsa034400.58277338
94Parkinsons disease_Homo sapiens_hsa050120.57885897
95Pyruvate metabolism_Homo sapiens_hsa006200.57540276
96Glucagon signaling pathway_Homo sapiens_hsa049220.56651075
97Protein digestion and absorption_Homo sapiens_hsa049740.55836428
98HIF-1 signaling pathway_Homo sapiens_hsa040660.55607224
99Galactose metabolism_Homo sapiens_hsa000520.55147080
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52857231
101Oxidative phosphorylation_Homo sapiens_hsa001900.51959021
102Fatty acid biosynthesis_Homo sapiens_hsa000610.51814757
103Glioma_Homo sapiens_hsa052140.50127413
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.49417008
105GnRH signaling pathway_Homo sapiens_hsa049120.49225872
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48605948
107MicroRNAs in cancer_Homo sapiens_hsa052060.46572763
108Thyroid cancer_Homo sapiens_hsa052160.46533750
109Purine metabolism_Homo sapiens_hsa002300.43599799
110Rheumatoid arthritis_Homo sapiens_hsa053230.43474247
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43287782
112Glycerolipid metabolism_Homo sapiens_hsa005610.42003696
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40486074
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38966287
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38931650
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.35903609
117Sphingolipid metabolism_Homo sapiens_hsa006000.33083224
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32565239
119Retinol metabolism_Homo sapiens_hsa008300.32313863
120MAPK signaling pathway_Homo sapiens_hsa040100.31559708
121Cocaine addiction_Homo sapiens_hsa050300.30212347
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29415584
123AMPK signaling pathway_Homo sapiens_hsa041520.28239651
124Choline metabolism in cancer_Homo sapiens_hsa052310.27743180
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24605164
126Amphetamine addiction_Homo sapiens_hsa050310.23950726
127Colorectal cancer_Homo sapiens_hsa052100.23868154
128* Alcoholism_Homo sapiens_hsa050340.23452237
129Thyroid hormone synthesis_Homo sapiens_hsa049180.22835522
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22294285
131Lysosome_Homo sapiens_hsa041420.21772413
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19555616
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19430551
134Renal cell carcinoma_Homo sapiens_hsa052110.19414592
135Ovarian steroidogenesis_Homo sapiens_hsa049130.18460904
136Endocytosis_Homo sapiens_hsa041440.17976651
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17910361
138Long-term depression_Homo sapiens_hsa047300.17530057
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17453595
140ECM-receptor interaction_Homo sapiens_hsa045120.14157790
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12408618
142Axon guidance_Homo sapiens_hsa043600.11688343
143Linoleic acid metabolism_Homo sapiens_hsa005910.11614842
144Lysine degradation_Homo sapiens_hsa003100.10030132
145Regulation of autophagy_Homo sapiens_hsa041400.08475878

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »