GNB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84495300
2synaptic vesicle exocytosis (GO:0016079)5.58196448
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48997720
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.41741779
5synaptic vesicle maturation (GO:0016188)5.33135619
6protein localization to synapse (GO:0035418)5.30392230
7regulation of synaptic vesicle exocytosis (GO:2000300)5.13994934
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08408829
9neurotransmitter-gated ion channel clustering (GO:0072578)4.80696155
10behavioral response to nicotine (GO:0035095)4.80432317
11vocalization behavior (GO:0071625)4.77425713
12glutamate secretion (GO:0014047)4.70824453
13locomotory exploration behavior (GO:0035641)4.61740797
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56411534
15regulation of synaptic vesicle transport (GO:1902803)4.47023219
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.46084698
17* rhodopsin mediated signaling pathway (GO:0016056)4.42979896
18* regulation of rhodopsin mediated signaling pathway (GO:0022400)4.41453141
19regulation of glutamate receptor signaling pathway (GO:1900449)4.28396487
20striatum development (GO:0021756)4.27588876
21regulation of synapse structural plasticity (GO:0051823)4.24494011
22neurotransmitter secretion (GO:0007269)4.23402969
23cellular potassium ion homeostasis (GO:0030007)4.16760636
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16345144
25positive regulation of synapse maturation (GO:0090129)4.12740495
26pyrimidine nucleobase catabolic process (GO:0006208)4.05280766
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04132054
28neuron-neuron synaptic transmission (GO:0007270)4.04010331
29detection of light stimulus involved in sensory perception (GO:0050962)3.92575488
30detection of light stimulus involved in visual perception (GO:0050908)3.92575488
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91515267
32retinal rod cell development (GO:0046548)3.82415274
33negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81231619
34exploration behavior (GO:0035640)3.80181724
35retinal cone cell development (GO:0046549)3.80064369
36positive regulation of neurotransmitter transport (GO:0051590)3.79272375
37long-term synaptic potentiation (GO:0060291)3.79170271
38synaptic transmission, glutamatergic (GO:0035249)3.78466993
39serotonin metabolic process (GO:0042428)3.77957403
40regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.77834436
41regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.77834436
42postsynaptic membrane organization (GO:0001941)3.76153138
43positive regulation of membrane potential (GO:0045838)3.75882392
44behavioral response to cocaine (GO:0048148)3.74265888
45synaptic transmission, dopaminergic (GO:0001963)3.71835189
46prepulse inhibition (GO:0060134)3.68574924
47regulation of neuronal synaptic plasticity (GO:0048168)3.68305530
48positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.68014251
49synaptic vesicle endocytosis (GO:0048488)3.66805343
50response to histamine (GO:0034776)3.66190736
51neuronal action potential propagation (GO:0019227)3.63802211
52sodium ion export (GO:0071436)3.63514679
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61839672
54transmission of nerve impulse (GO:0019226)3.60432198
55neuron cell-cell adhesion (GO:0007158)3.59965328
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.59414886
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58753964
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.58134829
59regulation of neurotransmitter secretion (GO:0046928)3.57915183
60primary amino compound metabolic process (GO:1901160)3.56108375
61glutamate receptor signaling pathway (GO:0007215)3.55631886
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.55209282
63membrane hyperpolarization (GO:0060081)3.53151781
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.51761120
65photoreceptor cell development (GO:0042461)3.48964542
66long-term memory (GO:0007616)3.47904021
67regulation of postsynaptic membrane potential (GO:0060078)3.46395562
68neurotransmitter transport (GO:0006836)3.46344613
69regulation of neurotransmitter transport (GO:0051588)3.43763977
70nucleobase catabolic process (GO:0046113)3.42753398
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42329704
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41704273
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.40793260
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40386496
75neurofilament cytoskeleton organization (GO:0060052)3.38075903
76dendritic spine morphogenesis (GO:0060997)3.37036466
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35972019
78cerebellar Purkinje cell differentiation (GO:0021702)3.29370688
79eye photoreceptor cell development (GO:0042462)3.28875426
80neuronal action potential (GO:0019228)3.28601399
81positive regulation of neurotransmitter secretion (GO:0001956)3.27743639
82innervation (GO:0060384)3.27408381
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26951621
84dopamine receptor signaling pathway (GO:0007212)3.26792033
85regulation of neurotransmitter uptake (GO:0051580)3.24583790
86layer formation in cerebral cortex (GO:0021819)3.24096757
87behavioral defense response (GO:0002209)3.23074078
88behavioral fear response (GO:0001662)3.23074078
89regulation of synaptic plasticity (GO:0048167)3.21895193
90positive regulation of synaptic transmission (GO:0050806)3.18972786
91regulation of synapse maturation (GO:0090128)3.17955361
92protein neddylation (GO:0045116)3.15551933
93activation of protein kinase A activity (GO:0034199)3.14974228
94membrane depolarization during action potential (GO:0086010)3.13928321
95response to auditory stimulus (GO:0010996)3.13269385
96auditory behavior (GO:0031223)3.12401066
97regulation of vesicle fusion (GO:0031338)3.12256443
98cell communication by electrical coupling (GO:0010644)3.09206868
99regulation of neurotransmitter levels (GO:0001505)3.06014982
100startle response (GO:0001964)3.05973778
101long term synaptic depression (GO:0060292)3.05609891
102photoreceptor cell maintenance (GO:0045494)3.05093225
103potassium ion homeostasis (GO:0055075)3.04847712
104gamma-aminobutyric acid transport (GO:0015812)3.04281567
105regulation of dendritic spine morphogenesis (GO:0061001)3.02680028
106L-fucose catabolic process (GO:0042355)3.02268707
107fucose catabolic process (GO:0019317)3.02268707
108L-fucose metabolic process (GO:0042354)3.02268707
109* regulation of voltage-gated calcium channel activity (GO:1901385)3.01773298
110behavioral response to ethanol (GO:0048149)3.00273415
111regulation of synaptic transmission, dopaminergic (GO:0032225)2.98832831
112membrane depolarization (GO:0051899)2.97738015
113synaptic transmission (GO:0007268)2.97208909
114negative regulation of appetite (GO:0032099)2.97069095
115negative regulation of response to food (GO:0032096)2.97069095
116presynaptic membrane assembly (GO:0097105)2.95997863
117negative regulation of heart rate (GO:0010459)2.95917965
118response to pheromone (GO:0019236)2.95909712
119fear response (GO:0042596)2.95753330
120neuromuscular process controlling balance (GO:0050885)2.94155816
121response to amphetamine (GO:0001975)2.91956285
122presynaptic membrane organization (GO:0097090)2.89541957
123dopamine transport (GO:0015872)2.85227490
124detection of calcium ion (GO:0005513)2.81744615
125synapse assembly (GO:0007416)2.77909220
126neuromuscular synaptic transmission (GO:0007274)2.76002858
127dopamine biosynthetic process (GO:0042416)2.71544041
128cellular ketone body metabolic process (GO:0046950)2.71072172
129regulation of calcium ion-dependent exocytosis (GO:0017158)2.64811731
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64146911
131cyclic nucleotide catabolic process (GO:0009214)2.63668775
132urinary tract smooth muscle contraction (GO:0014848)2.63199981
133glycerophospholipid catabolic process (GO:0046475)2.61063031
134indole-containing compound metabolic process (GO:0042430)2.60247980
135cellular potassium ion transport (GO:0071804)2.59147848
136potassium ion transmembrane transport (GO:0071805)2.59147848
137action potential (GO:0001508)2.57593477
138protein polyglutamylation (GO:0018095)2.56087011
139glycosphingolipid biosynthetic process (GO:0006688)2.55706193
140adult behavior (GO:0030534)2.54889192
141proline transport (GO:0015824)2.54556835
142central nervous system myelination (GO:0022010)2.54112941
143axon ensheathment in central nervous system (GO:0032291)2.54112941
144cAMP catabolic process (GO:0006198)2.51565941
145positive regulation of amino acid transport (GO:0051957)2.51513971
146negative regulation of telomere maintenance (GO:0032205)2.51136966
147sequestering of actin monomers (GO:0042989)2.51076669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18885099
2GBX2_23144817_ChIP-Seq_PC3_Human4.00194561
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12004969
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10377064
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.97248297
6REST_21632747_ChIP-Seq_MESCs_Mouse2.83227234
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82317812
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67339658
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64990902
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64990902
11DROSHA_22980978_ChIP-Seq_HELA_Human2.64345897
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55842969
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50883443
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50747755
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.47666244
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46653924
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.45147472
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32368925
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.30582047
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27471166
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25269606
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20459925
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.18352982
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16622090
25VDR_22108803_ChIP-Seq_LS180_Human2.14566268
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.14243123
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13062988
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84958958
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83413817
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81711148
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81560082
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81521608
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80597244
34AR_21572438_ChIP-Seq_LNCaP_Human1.78055916
35SMAD4_21799915_ChIP-Seq_A2780_Human1.74469494
36TAF15_26573619_Chip-Seq_HEK293_Human1.69548284
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59378493
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54310786
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52857794
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49542913
41FUS_26573619_Chip-Seq_HEK293_Human1.46524403
42EWS_26573619_Chip-Seq_HEK293_Human1.40869904
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.36910007
44P300_19829295_ChIP-Seq_ESCs_Human1.36416520
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35959270
46P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35446880
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.34819742
48BCAT_22108803_ChIP-Seq_LS180_Human1.34746809
49AR_19668381_ChIP-Seq_PC3_Human1.34110810
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.33598354
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32181740
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31555562
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30183572
54STAT3_23295773_ChIP-Seq_U87_Human1.29212399
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29189364
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.28830528
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28372286
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28093800
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.26335394
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25966061
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25360773
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25360773
63AR_25329375_ChIP-Seq_VCAP_Human1.24946844
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24158570
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24053034
66* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23451275
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22419831
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22096277
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.21409635
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21368926
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19876285
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19002169
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17678994
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.15582987
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14494223
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12802417
77TP53_22573176_ChIP-Seq_HFKS_Human1.12131273
78* TCF4_23295773_ChIP-Seq_U87_Human1.12065727
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11700387
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11270942
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11020536
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.09935133
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09569784
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08242831
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.08056295
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06359846
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06317097
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06080407
89RNF2_27304074_Chip-Seq_NSC_Mouse1.05932620
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05775942
91IRF1_19129219_ChIP-ChIP_H3396_Human1.05594591
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.02870934
93IGF1R_20145208_ChIP-Seq_DFB_Human1.02448285
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02137247
95NANOG_19829295_ChIP-Seq_ESCs_Human1.01439051
96SOX2_19829295_ChIP-Seq_ESCs_Human1.01439051
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.00825210
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00431828
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.00316351
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00255164
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99929687
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99595631
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.99251831
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.99085897
105HTT_18923047_ChIP-ChIP_STHdh_Human0.98399954
106TCF4_22108803_ChIP-Seq_LS180_Human0.97928683
107ZNF274_21170338_ChIP-Seq_K562_Hela0.97854325
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97839600
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97264670
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96790544
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96390828
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.95240833
113GATA3_21878914_ChIP-Seq_MCF-7_Human0.94467558
114* KDM2B_26808549_Chip-Seq_K562_Human0.94258000
115JUN_21703547_ChIP-Seq_K562_Human0.94183872
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93812635
117RUNX2_22187159_ChIP-Seq_PCA_Human0.93143976
118AHR_22903824_ChIP-Seq_MCF-7_Human0.92790077
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92453370
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92005298
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89983477
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89899040
123FLI1_21867929_ChIP-Seq_TH2_Mouse0.88031220
124CBP_20019798_ChIP-Seq_JUKART_Human0.86403202
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86403202
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85937154
127ER_23166858_ChIP-Seq_MCF-7_Human0.85778823
128* CTCF_27219007_Chip-Seq_Bcells_Human0.85502128
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84901697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27525645
2MP0005551_abnormal_eye_electrophysiolog4.02309803
3MP0003880_abnormal_central_pattern4.01901626
4MP0002822_catalepsy3.84386259
5MP0003635_abnormal_synaptic_transmissio3.66112351
6MP0004270_analgesia3.12274542
7MP0009745_abnormal_behavioral_response3.10372835
8MP0002063_abnormal_learning/memory/cond3.01930829
9* MP0002064_seizures2.85978586
10MP0001968_abnormal_touch/_nociception2.79080342
11* MP0009046_muscle_twitch2.73150329
12MP0003011_delayed_dark_adaptation2.56477676
13MP0006072_abnormal_retinal_apoptosis2.55167338
14MP0005423_abnormal_somatic_nervous2.54305514
15MP0002572_abnormal_emotion/affect_behav2.52958318
16MP0001486_abnormal_startle_reflex2.50665743
17MP0002272_abnormal_nervous_system2.50043240
18MP0005253_abnormal_eye_physiology2.44945409
19MP0002734_abnormal_mechanical_nocicepti2.40670453
20MP0001984_abnormal_olfaction2.21585353
21MP0002736_abnormal_nociception_after2.16301775
22MP0002090_abnormal_vision2.02889672
23MP0009780_abnormal_chondrocyte_physiolo1.91349804
24MP0008877_abnormal_DNA_methylation1.91343408
25MP0000569_abnormal_digit_pigmentation1.90432628
26MP0001501_abnormal_sleep_pattern1.85519170
27* MP0002067_abnormal_sensory_capabilities1.84047188
28MP0008569_lethality_at_weaning1.81916696
29MP0002909_abnormal_adrenal_gland1.81623850
30MP0005646_abnormal_pituitary_gland1.78125456
31MP0002735_abnormal_chemical_nociception1.76526220
32MP0003136_yellow_coat_color1.73131419
33MP0001529_abnormal_vocalization1.70253453
34MP0001502_abnormal_circadian_rhythm1.66377952
35MP0001970_abnormal_pain_threshold1.65764598
36MP0005386_behavior/neurological_phenoty1.62793133
37MP0004924_abnormal_behavior1.62793133
38MP0002184_abnormal_innervation1.61288596
39MP0002229_neurodegeneration1.60114681
40MP0003879_abnormal_hair_cell1.57607957
41* MP0002882_abnormal_neuron_morphology1.56094450
42MP0004811_abnormal_neuron_physiology1.54225930
43MP0002557_abnormal_social/conspecific_i1.51892635
44MP0004233_abnormal_muscle_weight1.51550456
45MP0002733_abnormal_thermal_nociception1.51230071
46MP0001440_abnormal_grooming_behavior1.50866933
47MP0002638_abnormal_pupillary_reflex1.50857794
48MP0001485_abnormal_pinna_reflex1.48796654
49MP0005195_abnormal_posterior_eye1.45133978
50MP0002102_abnormal_ear_morphology1.43449286
51MP0000751_myopathy1.34309699
52MP0000013_abnormal_adipose_tissue1.31905876
53MP0004885_abnormal_endolymph1.27596046
54MP0005394_taste/olfaction_phenotype1.27294485
55MP0005499_abnormal_olfactory_system1.27294485
56MP0005084_abnormal_gallbladder_morpholo1.27091877
57MP0000955_abnormal_spinal_cord1.26719961
58MP0003787_abnormal_imprinting1.26397494
59MP0008875_abnormal_xenobiotic_pharmacok1.24958157
60* MP0002066_abnormal_motor_capabilities/c1.23961999
61MP0002752_abnormal_somatic_nervous1.20453673
62MP0004858_abnormal_nervous_system1.19609175
63MP0000778_abnormal_nervous_system1.19540372
64MP0002653_abnormal_ependyma_morphology1.19453246
65MP0003329_amyloid_beta_deposits1.19203337
66MP0004215_abnormal_myocardial_fiber1.17830924
67MP0010386_abnormal_urinary_bladder1.17765807
68MP0003122_maternal_imprinting1.16895745
69MP0001188_hyperpigmentation1.15437000
70MP0003633_abnormal_nervous_system1.14533771
71MP0004142_abnormal_muscle_tone1.12928589
72MP0006276_abnormal_autonomic_nervous1.10344015
73MP0003195_calcinosis1.08474481
74MP0004133_heterotaxia1.06763401
75MP0001324_abnormal_eye_pigmentation1.05067893
76MP0005174_abnormal_tail_pigmentation1.04014780
77MP0004085_abnormal_heartbeat1.02978114
78MP0001986_abnormal_taste_sensitivity1.02964854
79MP0001905_abnormal_dopamine_level0.99926644
80MP0005377_hearing/vestibular/ear_phenot0.99359175
81MP0003878_abnormal_ear_physiology0.99359175
82MP0008872_abnormal_physiological_respon0.99240816
83MP0002837_dystrophic_cardiac_calcinosis0.94974896
84MP0000230_abnormal_systemic_arterial0.94891442
85MP0003121_genomic_imprinting0.93417012
86MP0004145_abnormal_muscle_electrophysio0.91677578
87MP0003634_abnormal_glial_cell0.91465942
88* MP0002152_abnormal_brain_morphology0.90707745
89MP0003631_nervous_system_phenotype0.90386015
90MP0002069_abnormal_eating/drinking_beha0.89283983
91MP0002160_abnormal_reproductive_system0.88505289
92MP0000026_abnormal_inner_ear0.87056561
93MP0004147_increased_porphyrin_level0.86499460
94MP0004036_abnormal_muscle_relaxation0.86354873
95MP0005410_abnormal_fertilization0.85984083
96MP0004043_abnormal_pH_regulation0.85392209
97MP0004130_abnormal_muscle_cell0.84055806
98MP0000631_abnormal_neuroendocrine_gland0.83461106
99MP0005391_vision/eye_phenotype0.83042918
100MP0001177_atelectasis0.82637313
101MP0005464_abnormal_platelet_physiology0.82022596
102MP0003950_abnormal_plasma_membrane0.81403799
103MP0003137_abnormal_impulse_conducting0.80186129
104MP0005645_abnormal_hypothalamus_physiol0.80039315
105MP0003183_abnormal_peptide_metabolism0.79043852
106MP0002928_abnormal_bile_duct0.75536823
107MP0001963_abnormal_hearing_physiology0.74862686
108MP0005187_abnormal_penis_morphology0.74757605
109MP0008961_abnormal_basal_metabolism0.72402872
110MP0003698_abnormal_male_reproductive0.69181505
111MP0003638_abnormal_response/metabolism_0.69050717
112MP0008874_decreased_physiological_sensi0.67404411
113MP0005535_abnormal_body_temperature0.66596261
114MP0004084_abnormal_cardiac_muscle0.66162066
115MP0003283_abnormal_digestive_organ0.66084459
116MP0001765_abnormal_ion_homeostasis0.65385944
117MP0005389_reproductive_system_phenotype0.64450255
118MP0003646_muscle_fatigue0.64415017
119MP0005620_abnormal_muscle_contractility0.64317404
120MP0006292_abnormal_olfactory_placode0.64238274
121MP0008789_abnormal_olfactory_epithelium0.63376892
122MP0004742_abnormal_vestibular_system0.63216077
123MP0002876_abnormal_thyroid_physiology0.61935562
124MP0002332_abnormal_exercise_endurance0.61535170
125MP0001664_abnormal_digestion0.52782332
126MP0003632_abnormal_nervous_system0.51751110

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.50849869
2Focal motor seizures (HP:0011153)6.06287815
3Myokymia (HP:0002411)5.79439725
4Central scotoma (HP:0000603)5.73176927
5Bony spicule pigmentary retinopathy (HP:0007737)5.29551339
6Abnormal rod and cone electroretinograms (HP:0008323)5.02407220
7Epileptic encephalopathy (HP:0200134)4.72533004
8Abnormality of macular pigmentation (HP:0008002)4.57636307
9Scotoma (HP:0000575)4.49328583
10Focal seizures (HP:0007359)4.36510116
11Visual hallucinations (HP:0002367)4.26607565
12Febrile seizures (HP:0002373)4.21693926
13Absent rod-and cone-mediated responses on ERG (HP:0007688)4.03801786
14Limb dystonia (HP:0002451)3.87875865
15Atonic seizures (HP:0010819)3.85744867
16Progressive cerebellar ataxia (HP:0002073)3.72753870
17Absence seizures (HP:0002121)3.56174931
18Decreased central vision (HP:0007663)3.46572162
19Chorioretinal atrophy (HP:0000533)3.39473923
20Attenuation of retinal blood vessels (HP:0007843)3.36804832
21Molar tooth sign on MRI (HP:0002419)3.35897482
22Abnormality of midbrain morphology (HP:0002418)3.35897482
23Dysdiadochokinesis (HP:0002075)3.28782052
24Action tremor (HP:0002345)3.27759367
25Pigmentary retinal degeneration (HP:0001146)3.27370367
26Pancreatic cysts (HP:0001737)3.18674575
27Dialeptic seizures (HP:0011146)3.17106189
28Inability to walk (HP:0002540)3.15297059
29Polyphagia (HP:0002591)3.14691760
30Generalized tonic-clonic seizures (HP:0002069)3.12680283
31Dyschromatopsia (HP:0007641)3.07049426
32Abnormality of binocular vision (HP:0011514)3.06242306
33Diplopia (HP:0000651)3.06242306
34Pendular nystagmus (HP:0012043)3.03465836
35Depression (HP:0000716)3.00848882
36Pancreatic fibrosis (HP:0100732)2.99684404
37Severe visual impairment (HP:0001141)2.98317885
38Gaze-evoked nystagmus (HP:0000640)2.94049858
39Gait imbalance (HP:0002141)2.88091006
40True hermaphroditism (HP:0010459)2.87275048
41Ankle clonus (HP:0011448)2.86236213
42Abolished electroretinogram (ERG) (HP:0000550)2.86075853
43Type II diabetes mellitus (HP:0005978)2.77176710
44Truncal ataxia (HP:0002078)2.73951593
45Nephronophthisis (HP:0000090)2.73615847
46Anxiety (HP:0000739)2.72651162
47Morphological abnormality of the pyramidal tract (HP:0002062)2.71458953
48Congenital primary aphakia (HP:0007707)2.71219765
49Increased corneal curvature (HP:0100692)2.68196581
50Keratoconus (HP:0000563)2.68196581
51Broad-based gait (HP:0002136)2.65519266
52Impaired vibration sensation in the lower limbs (HP:0002166)2.65017529
53Hyperventilation (HP:0002883)2.64078491
54Dysmetric saccades (HP:0000641)2.63474699
55Abnormality of the corticospinal tract (HP:0002492)2.63406959
56Pheochromocytoma (HP:0002666)2.61524832
57Choroideremia (HP:0001139)2.59100242
58Photophobia (HP:0000613)2.57347575
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55623644
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.55623644
61Type II lissencephaly (HP:0007260)2.55516752
62Lissencephaly (HP:0001339)2.52451589
63Poor eye contact (HP:0000817)2.51786803
64Abnormality of alanine metabolism (HP:0010916)2.51607175
65Hyperalaninemia (HP:0003348)2.51607175
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51607175
67Urinary bladder sphincter dysfunction (HP:0002839)2.50000090
68Thyroid-stimulating hormone excess (HP:0002925)2.46044942
69Nephrogenic diabetes insipidus (HP:0009806)2.45301898
70Torticollis (HP:0000473)2.42650547
71Abnormal eating behavior (HP:0100738)2.39288390
72Medial flaring of the eyebrow (HP:0010747)2.38989772
73Absent speech (HP:0001344)2.37315672
74Impaired social interactions (HP:0000735)2.36758507
75Abnormal social behavior (HP:0012433)2.36758507
76Retinitis pigmentosa (HP:0000510)2.36022850
77Abnormality of the lower motor neuron (HP:0002366)2.33449769
78Dysmetria (HP:0001310)2.32307719
79Postural instability (HP:0002172)2.30916894
80Scanning speech (HP:0002168)2.29274650
81Epileptiform EEG discharges (HP:0011182)2.29143066
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28926071
83Progressive inability to walk (HP:0002505)2.28288377
84Neuroendocrine neoplasm (HP:0100634)2.27743218
85Supranuclear gaze palsy (HP:0000605)2.24282584
86Resting tremor (HP:0002322)2.24083226
87Protruding tongue (HP:0010808)2.23808803
88Impaired smooth pursuit (HP:0007772)2.23118865
89Abnormality of the renal medulla (HP:0100957)2.19697358
90Agitation (HP:0000713)2.19695557
91Dyskinesia (HP:0100660)2.19532770
92EEG with generalized epileptiform discharges (HP:0011198)2.18578890
93Prolonged QT interval (HP:0001657)2.18558396
94Optic nerve hypoplasia (HP:0000609)2.18416940
95Focal dystonia (HP:0004373)2.16829915
96Hypothermia (HP:0002045)2.15250297
97Abnormality of the renal cortex (HP:0011035)2.12100077
98Macular degeneration (HP:0000608)2.10277791
99Polydipsia (HP:0001959)2.09922542
100Abnormal drinking behavior (HP:0030082)2.09922542
101Annular pancreas (HP:0001734)2.08478849
102Mutism (HP:0002300)2.07895147
103Bradykinesia (HP:0002067)2.07845261
104Genetic anticipation (HP:0003743)2.07658900
105Cystic liver disease (HP:0006706)2.07326910
106Prolonged bleeding time (HP:0003010)2.05065132
107Amblyopia (HP:0000646)2.04177447
108Craniofacial dystonia (HP:0012179)2.03864829
109Ventricular fibrillation (HP:0001663)2.03437158
110Menorrhagia (HP:0000132)2.03187790
111Abnormality of ocular smooth pursuit (HP:0000617)2.00748653
112Poor coordination (HP:0002370)2.00537875
113Abnormal EKG (HP:0003115)1.99747681
114Fair hair (HP:0002286)1.99700937
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98843788
116Decreased circulating renin level (HP:0003351)1.96312102
117Drooling (HP:0002307)1.96310207
118Excessive salivation (HP:0003781)1.96310207
119Pachygyria (HP:0001302)1.96156162
120Urinary urgency (HP:0000012)1.96033893
121Specific learning disability (HP:0001328)1.95563208
122Renal cortical cysts (HP:0000803)1.95449005
123Exercise-induced myalgia (HP:0003738)1.94634024
124Spastic tetraplegia (HP:0002510)1.94354297
125Hyperlipoproteinemia (HP:0010980)1.93966921
126Vaginal atresia (HP:0000148)1.93856816
127Cholecystitis (HP:0001082)1.93427560
128Abnormal gallbladder physiology (HP:0012438)1.93427560
129Spastic gait (HP:0002064)1.93039650
130Hypsarrhythmia (HP:0002521)1.92838345
131Hemiparesis (HP:0001269)1.92532064
132Genital tract atresia (HP:0001827)1.92297289
133Constricted visual fields (HP:0001133)1.92093235
1343-Methylglutaconic aciduria (HP:0003535)1.90228938
135Congenital, generalized hypertrichosis (HP:0004540)1.89877024
136Status epilepticus (HP:0002133)1.89124289
137Clumsiness (HP:0002312)1.88282334
138Hemiplegia (HP:0002301)1.87886639
139Impaired vibratory sensation (HP:0002495)1.86594211
140Hypoventilation (HP:0002791)1.86016850
141Abnormal ciliary motility (HP:0012262)1.82958865
142Incomplete penetrance (HP:0003829)1.82504936
143Abnormal respiratory epithelium morphology (HP:0012253)1.81213150
144Abnormal respiratory motile cilium morphology (HP:0005938)1.81213150
145Chronic hepatic failure (HP:0100626)1.80369341
146Absent/shortened dynein arms (HP:0200106)1.79751399
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.79751399
148Widely spaced teeth (HP:0000687)1.79278484
149Lower limb muscle weakness (HP:0007340)1.78636230
150Sleep apnea (HP:0010535)1.78323172
151Generalized hypopigmentation of hair (HP:0011358)1.77557392
152Posterior subcapsular cataract (HP:0007787)1.77078514
153Stereotypic behavior (HP:0000733)1.75150512
154Optic disc pallor (HP:0000543)1.73280995
155Retinal dysplasia (HP:0007973)1.71299077
156Intention tremor (HP:0002080)1.70474796
157Abnormality of the labia minora (HP:0012880)1.70148019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.57203590
2NTRK33.80258470
3FRK3.46466209
4MAP3K93.03699965
5MAP3K43.00785594
6CASK2.78206050
7MINK12.57528659
8DAPK22.52982783
9ADRBK22.51097367
10MAP2K72.42227777
11TAOK32.37721011
12PAK62.27490447
13PRPF4B2.24035616
14BMPR1B2.23433409
15NEK12.07379985
16MARK12.04080632
17PRKD32.02704955
18KSR21.98460865
19WNK31.98195146
20CAMKK11.92608171
21PNCK1.91712970
22MAP3K121.87156921
23DAPK11.72397740
24DYRK21.71327074
25KSR11.63201254
26ZAK1.63139958
27WNK41.58479527
28NTRK21.57732097
29CAMKK21.56485079
30PLK21.55582272
31MAP2K41.55438160
32ARAF1.55001500
33MAP4K21.51149950
34SGK4941.47509653
35SGK2231.47509653
36CDK51.46426521
37STK381.42573609
38TLK11.39623408
39SGK21.37472133
40CDK191.36738511
41GRK51.34675036
42NTRK11.29782454
43PINK11.27881820
44RIPK41.26327731
45GRK11.26321515
46PRKCG1.24351810
47FES1.22103361
48SIK31.19137513
49AKT31.18472395
50ACVR1B1.12796224
51CSNK1G21.10635157
52MAP3K131.09227111
53PHKG21.06868538
54PHKG11.06868538
55SGK31.04354391
56CDK181.04055223
57TRIM281.02021258
58MAPK131.00881445
59PRKCH1.00231821
60TNIK0.99492481
61LMTK20.98853535
62CDK150.97714283
63CDK140.96420973
64CSNK1G30.95559426
65CAMK2A0.94826324
66PKN10.93375482
67SIK20.92636378
68DYRK1A0.90296399
69CCNB10.88112228
70CSNK1G10.87736864
71TXK0.85129405
72MAPKAPK30.84943359
73CAMK10.84300580
74CDK11A0.82927878
75MAP3K20.81925112
76EPHA30.80959517
77NME10.80526298
78TNK20.79936521
79NUAK10.77416766
80PBK0.74900798
81LIMK10.74790412
82RAF10.72687928
83PTK2B0.71617350
84MAPKAPK50.71415094
85UHMK10.68742254
86SGK10.67659809
87BRAF0.67445665
88CAMK2D0.67353469
89MYLK0.66358450
90FER0.66186485
91BCR0.65962604
92PRKCE0.65800138
93RET0.65518606
94OXSR10.64785482
95CSNK1A1L0.64557028
96CAMK2B0.62263396
97TAOK10.61420914
98NEK60.61303604
99BMPR20.60130396
100PIK3CA0.59404031
101MAP2K10.59232446
102RIPK10.57103617
103PAK30.56592023
104TYRO30.56320152
105STK110.55822838
106RPS6KA30.55391880
107CDC42BPA0.55186352
108PRKCZ0.54148857
109MAP3K10.52845441
110SYK0.52623565
111RPS6KA50.52104489
112PDK10.50854553
113CAMK40.50152077
114CSNK1D0.49116568
115PDK30.49015362
116PDK40.49015362
117ADRBK10.48911561
118BRSK10.48553206
119DAPK30.48336568
120MARK20.46797422
121PRKCQ0.46588685
122PDPK10.46553166
123STK390.45808476
124FGFR20.45629155
125PRKCB0.44901693
126CAMK2G0.44858794
127WNK10.44690921
128INSRR0.44239372
129MAPK120.43457620
130MAPK100.42981840
131PRKCA0.42547881
132TSSK60.42048561
133PRKG10.41898323
134TGFBR10.41748039
135RPS6KA20.41315560
136TAOK20.39206529
137MAP3K70.39073575
138VRK10.38996530
139CSNK1A10.38894963
140PRKACA0.38699837
141CAMK1G0.37589662
142PRKCI0.37587580
143TEC0.35293255
144BMX0.34277348

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.14988239
2Synaptic vesicle cycle_Homo sapiens_hsa047213.90494818
3Nicotine addiction_Homo sapiens_hsa050333.51542044
4Olfactory transduction_Homo sapiens_hsa047403.12650809
5* GABAergic synapse_Homo sapiens_hsa047272.81728914
6* Morphine addiction_Homo sapiens_hsa050322.64685610
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59759133
8* Circadian entrainment_Homo sapiens_hsa047132.55219372
9* Glutamatergic synapse_Homo sapiens_hsa047242.15154504
10Nitrogen metabolism_Homo sapiens_hsa009102.13305848
11Long-term potentiation_Homo sapiens_hsa047202.09946370
12Butanoate metabolism_Homo sapiens_hsa006502.07365309
13Amphetamine addiction_Homo sapiens_hsa050312.06713897
14* Dopaminergic synapse_Homo sapiens_hsa047282.04472262
15Insulin secretion_Homo sapiens_hsa049112.00532476
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94333246
17Collecting duct acid secretion_Homo sapiens_hsa049661.90709767
18Salivary secretion_Homo sapiens_hsa049701.90153014
19* Cholinergic synapse_Homo sapiens_hsa047251.84433605
20Renin secretion_Homo sapiens_hsa049241.66509898
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62579421
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60950892
23Taste transduction_Homo sapiens_hsa047421.60071741
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58252927
25Cocaine addiction_Homo sapiens_hsa050301.56431739
26Gastric acid secretion_Homo sapiens_hsa049711.49104252
27Linoleic acid metabolism_Homo sapiens_hsa005911.48816723
28* Serotonergic synapse_Homo sapiens_hsa047261.46369428
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46338632
30Calcium signaling pathway_Homo sapiens_hsa040201.44528273
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40983723
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35334040
33Long-term depression_Homo sapiens_hsa047301.33333883
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30996720
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28095068
36Vibrio cholerae infection_Homo sapiens_hsa051101.26210512
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25919728
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21940653
39Cardiac muscle contraction_Homo sapiens_hsa042601.20520373
40Gap junction_Homo sapiens_hsa045401.19838390
41cAMP signaling pathway_Homo sapiens_hsa040241.17634783
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17262309
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12919267
44GnRH signaling pathway_Homo sapiens_hsa049121.09682453
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08503024
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07404068
47Type II diabetes mellitus_Homo sapiens_hsa049301.06546099
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05069542
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02542062
50Ether lipid metabolism_Homo sapiens_hsa005650.98898336
51Circadian rhythm_Homo sapiens_hsa047100.98848934
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97385283
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97034573
54Dilated cardiomyopathy_Homo sapiens_hsa054140.96029035
55Selenocompound metabolism_Homo sapiens_hsa004500.93209087
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.88560642
57beta-Alanine metabolism_Homo sapiens_hsa004100.82057619
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81111079
59Glioma_Homo sapiens_hsa052140.80225366
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80118281
61Estrogen signaling pathway_Homo sapiens_hsa049150.78315738
62Platelet activation_Homo sapiens_hsa046110.76616488
63Arachidonic acid metabolism_Homo sapiens_hsa005900.73462293
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73223298
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71509901
66ErbB signaling pathway_Homo sapiens_hsa040120.71493679
67Melanogenesis_Homo sapiens_hsa049160.71032249
68Tryptophan metabolism_Homo sapiens_hsa003800.70129539
69Regulation of autophagy_Homo sapiens_hsa041400.68123122
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.68086465
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.67910554
72Oocyte meiosis_Homo sapiens_hsa041140.67787812
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65109204
74Pancreatic secretion_Homo sapiens_hsa049720.64816881
75Huntingtons disease_Homo sapiens_hsa050160.63308506
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62634137
77Axon guidance_Homo sapiens_hsa043600.62624984
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62583086
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62119072
80ABC transporters_Homo sapiens_hsa020100.60699404
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60380465
82Glucagon signaling pathway_Homo sapiens_hsa049220.60301688
83Thyroid hormone synthesis_Homo sapiens_hsa049180.59945841
84Chemical carcinogenesis_Homo sapiens_hsa052040.59945629
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.58834115
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58155148
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57852236
88mTOR signaling pathway_Homo sapiens_hsa041500.56822121
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56596372
90Inositol phosphate metabolism_Homo sapiens_hsa005620.55901439
91Fructose and mannose metabolism_Homo sapiens_hsa000510.55141226
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53584500
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53560451
94MAPK signaling pathway_Homo sapiens_hsa040100.53385467
95* Alcoholism_Homo sapiens_hsa050340.51260852
96Glycerolipid metabolism_Homo sapiens_hsa005610.46670581
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.45770697
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45323278
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44904585
100Basal transcription factors_Homo sapiens_hsa030220.43690187
101Choline metabolism in cancer_Homo sapiens_hsa052310.43562180
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43081681
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42596655
104Dorso-ventral axis formation_Homo sapiens_hsa043200.42303574
105Peroxisome_Homo sapiens_hsa041460.41851380
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41104672
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39381728
108Endometrial cancer_Homo sapiens_hsa052130.39142538
109Type I diabetes mellitus_Homo sapiens_hsa049400.38879335
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38257299
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38027221
112Endocytosis_Homo sapiens_hsa041440.37943648
113Rap1 signaling pathway_Homo sapiens_hsa040150.37645524
114Alzheimers disease_Homo sapiens_hsa050100.37529042
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37488673
116Insulin signaling pathway_Homo sapiens_hsa049100.37221722
117Fatty acid elongation_Homo sapiens_hsa000620.36564205
118* Ras signaling pathway_Homo sapiens_hsa040140.36514183
119Retinol metabolism_Homo sapiens_hsa008300.36085358
120Histidine metabolism_Homo sapiens_hsa003400.35792494
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35738784
122Oxidative phosphorylation_Homo sapiens_hsa001900.34773959
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.34700117
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32445304
125Parkinsons disease_Homo sapiens_hsa050120.31995062
126Non-small cell lung cancer_Homo sapiens_hsa052230.31923885
127Rheumatoid arthritis_Homo sapiens_hsa053230.31712929
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31191510
129Hedgehog signaling pathway_Homo sapiens_hsa043400.30746560
130RNA polymerase_Homo sapiens_hsa030200.30284093
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30005606
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28935196
133HIF-1 signaling pathway_Homo sapiens_hsa040660.28155621
134Bile secretion_Homo sapiens_hsa049760.27259812
135VEGF signaling pathway_Homo sapiens_hsa043700.26867434
136Vitamin B6 metabolism_Homo sapiens_hsa007500.26840551
137Renal cell carcinoma_Homo sapiens_hsa052110.26479834
138Ovarian steroidogenesis_Homo sapiens_hsa049130.23512348
139Biosynthesis of amino acids_Homo sapiens_hsa012300.23458042
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23127030
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22802442

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