GNG11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.52714272
2regulation of integrin-mediated signaling pathway (GO:2001044)6.58626874
3thrombin receptor signaling pathway (GO:0070493)6.56245486
4positive regulation of endothelial cell differentiation (GO:0045603)6.07818921
5angiogenesis involved in wound healing (GO:0060055)5.99259986
6ensheathment of neurons (GO:0007272)5.70380107
7axon ensheathment (GO:0008366)5.70380107
8myelination (GO:0042552)5.69882532
9negative regulation of protein localization to cell surface (GO:2000009)5.63999232
10negative regulation of platelet activation (GO:0010544)5.44661977
11negative regulation of homotypic cell-cell adhesion (GO:0034111)5.39660231
12myelin maintenance (GO:0043217)5.17023752
13long-chain fatty acid biosynthetic process (GO:0042759)5.16628936
14regulation of endothelial cell differentiation (GO:0045601)5.01899560
15regulation of platelet aggregation (GO:0090330)4.97118699
16neutrophil activation involved in immune response (GO:0002283)4.96160557
17regulation of platelet activation (GO:0010543)4.91698163
18blood coagulation, intrinsic pathway (GO:0007597)4.83944006
19extracellular fibril organization (GO:0043206)4.79683562
20negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.79445654
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76383624
22platelet aggregation (GO:0070527)4.55423398
23regulation of lipoprotein metabolic process (GO:0050746)4.53644503
24lymph vessel development (GO:0001945)4.48408775
25adenosine receptor signaling pathway (GO:0001973)4.45626936
26amyloid precursor protein metabolic process (GO:0042982)4.44494053
27response to methylmercury (GO:0051597)4.41991088
28platelet degranulation (GO:0002576)4.37018211
29positive regulation of receptor recycling (GO:0001921)4.24508223
30peptidyl-tyrosine autophosphorylation (GO:0038083)4.20441969
31negative regulation of neurotransmitter transport (GO:0051589)4.20096434
32cholesterol biosynthetic process (GO:0006695)4.14949247
33negative regulation of thymocyte apoptotic process (GO:0070244)4.06377475
34creatine metabolic process (GO:0006600)4.00590231
35sequestering of actin monomers (GO:0042989)3.93272515
36negative regulation of norepinephrine secretion (GO:0010700)3.89000208
37positive regulation of Rho protein signal transduction (GO:0035025)3.88801924
38positive regulation of oligodendrocyte differentiation (GO:0048714)3.88334285
39negative regulation of heart rate (GO:0010459)3.88191191
40fibril organization (GO:0097435)3.86285879
41regulation of collateral sprouting (GO:0048670)3.86125030
42L-amino acid import (GO:0043092)3.83912558
43platelet dense granule organization (GO:0060155)3.80513356
44establishment of mitochondrion localization (GO:0051654)3.80097914
45sterol biosynthetic process (GO:0016126)3.80085654
46blood vessel maturation (GO:0001955)3.79767546
47endothelium development (GO:0003158)3.76454693
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.74555940
49isoprenoid biosynthetic process (GO:0008299)3.71852083
50negative regulation of appetite (GO:0032099)3.70996635
51negative regulation of response to food (GO:0032096)3.70996635
52protein neddylation (GO:0045116)3.70673614
53eye photoreceptor cell differentiation (GO:0001754)3.69780378
54photoreceptor cell differentiation (GO:0046530)3.69780378
55neuron remodeling (GO:0016322)3.68607379
56negative regulation of neurotransmitter secretion (GO:0046929)3.68094274
57negative regulation of Rho protein signal transduction (GO:0035024)3.62906860
58import into cell (GO:0098657)3.59293808
59regulation of homotypic cell-cell adhesion (GO:0034110)3.53862575
60long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.52143291
61response to lipoprotein particle (GO:0055094)3.50124723
62GPI anchor biosynthetic process (GO:0006506)3.49158157
63phagocytosis, engulfment (GO:0006911)3.44585910
64regulation of macrophage derived foam cell differentiation (GO:0010743)3.41967640
65regulation of integrin activation (GO:0033623)3.39425102
66astrocyte development (GO:0014002)3.33933409
67heme transport (GO:0015886)3.33700362
68negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.32887342
69extracellular matrix assembly (GO:0085029)3.32441022
70lipoxygenase pathway (GO:0019372)3.31289869
71membrane tubulation (GO:0097320)3.30516745
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.29610389
73platelet activation (GO:0030168)3.27703553
74phospholipid homeostasis (GO:0055091)3.27135236
75limb bud formation (GO:0060174)3.23654293
76regulation of somitogenesis (GO:0014807)3.22877052
77fusion of sperm to egg plasma membrane (GO:0007342)3.20937829
78GPI anchor metabolic process (GO:0006505)3.20043520
79very long-chain fatty acid metabolic process (GO:0000038)3.19869458
80regulation of receptor recycling (GO:0001919)3.19152701
81retina vasculature morphogenesis in camera-type eye (GO:0061299)3.18318068
82membrane invagination (GO:0010324)3.14712200
83positive regulation of blood coagulation (GO:0030194)3.13593733
84positive regulation of hemostasis (GO:1900048)3.13593733
85substrate adhesion-dependent cell spreading (GO:0034446)3.11697999
86oligodendrocyte differentiation (GO:0048709)3.08930884
87neurotransmitter uptake (GO:0001504)3.08619738
88preassembly of GPI anchor in ER membrane (GO:0016254)3.08345213
89plasma membrane fusion (GO:0045026)3.08047534
90phospholipid scrambling (GO:0017121)3.06416270
91axon development (GO:0061564)3.06115928
92negative regulation of chemokine production (GO:0032682)3.05078104
93tonic smooth muscle contraction (GO:0014820)3.04606728
94fatty-acyl-CoA metabolic process (GO:0035337)3.04277244
95tissue regeneration (GO:0042246)3.03663062
96positive regulation of pseudopodium assembly (GO:0031274)3.03132201
97fatty-acyl-CoA biosynthetic process (GO:0046949)3.02920823
98calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01614143
99peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.01541808
100enteric nervous system development (GO:0048484)3.01449501
101amyloid precursor protein catabolic process (GO:0042987)3.00892340
102low-density lipoprotein particle remodeling (GO:0034374)2.99186851
103positive regulation of vasculogenesis (GO:2001214)2.97335511
104positive regulation of cell junction assembly (GO:1901890)2.96649922
105positive regulation of focal adhesion assembly (GO:0051894)2.96649922
106response to redox state (GO:0051775)2.95424644
107positive regulation of systemic arterial blood pressure (GO:0003084)2.94970320
108glycerophospholipid catabolic process (GO:0046475)2.94883088
109negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.93976613
110wound healing, spreading of epidermal cells (GO:0035313)2.93400609
111lymphangiogenesis (GO:0001946)2.92214241
112homotypic cell-cell adhesion (GO:0034109)2.91469977
113vascular endothelial growth factor signaling pathway (GO:0038084)2.88437409
114megakaryocyte development (GO:0035855)2.88364297
115autophagic vacuole fusion (GO:0000046)2.88218825
116negative regulation of neural precursor cell proliferation (GO:2000178)2.87274178
117sodium-independent organic anion transport (GO:0043252)2.87217961
118amino acid import (GO:0043090)2.86752041
119positive regulation of muscle hypertrophy (GO:0014742)2.85747738
120positive regulation of cardiac muscle hypertrophy (GO:0010613)2.85747738
121negative regulation of calcium ion transport into cytosol (GO:0010523)2.85342590
122positive regulation of macrophage differentiation (GO:0045651)2.84499508
123potassium ion import (GO:0010107)2.84015825
124iron coordination entity transport (GO:1901678)2.83153897
125protein palmitoylation (GO:0018345)2.82961896
126polyamine biosynthetic process (GO:0006596)2.82037244
127regulation of sensory perception of pain (GO:0051930)2.81950416
128regulation of sensory perception (GO:0051931)2.81950416
129membrane raft organization (GO:0031579)2.81545144
130positive regulation of cAMP-mediated signaling (GO:0043950)2.81411317
131leukocyte migration involved in inflammatory response (GO:0002523)2.80439955
132positive regulation of glial cell differentiation (GO:0045687)2.79501527
133regulation of blood coagulation (GO:0030193)2.78811277
134regulation of hemostasis (GO:1900046)2.78811277
135regulation of metalloenzyme activity (GO:0048552)2.77708525
136negative regulation of hemostasis (GO:1900047)2.77084779
137negative regulation of blood coagulation (GO:0030195)2.77084779
138platelet formation (GO:0030220)2.77045918
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76369914
140negative regulation of coagulation (GO:0050819)2.76285075
141positive regulation of coagulation (GO:0050820)2.75719723
142cerebral cortex radially oriented cell migration (GO:0021799)2.75174314
143positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.75032755
144negative regulation of calcium ion transmembrane transport (GO:1903170)2.73627077
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.73627077
146mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71802777
147beta-amyloid metabolic process (GO:0050435)2.71773266
148phagocytosis, recognition (GO:0006910)2.71730105
149substantia nigra development (GO:0021762)2.70059719
150regulation of Golgi to plasma membrane protein transport (GO:0042996)2.69037346
151regulation of vasculogenesis (GO:2001212)2.68884747
152mannosylation (GO:0097502)2.67920914
153sprouting angiogenesis (GO:0002040)2.67436874
154regulation of coagulation (GO:0050818)2.67386856
155termination of G-protein coupled receptor signaling pathway (GO:0038032)2.66441542
156heart process (GO:0003015)2.66402444
157heart contraction (GO:0060047)2.66402444
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.64849319
159regulation of pseudopodium assembly (GO:0031272)2.64337984
160positive regulation of adherens junction organization (GO:1903393)2.64315031
161magnesium ion transport (GO:0015693)2.62718011
162asymmetric protein localization (GO:0008105)2.61409956
163mesodermal cell differentiation (GO:0048333)2.57112908
164presynaptic membrane organization (GO:0097090)2.56568258
165peripheral nervous system axon ensheathment (GO:0032292)2.56004717
166myelination in peripheral nervous system (GO:0022011)2.56004717
167positive regulation of gliogenesis (GO:0014015)2.55570999
168cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.54745331
169glycosylceramide metabolic process (GO:0006677)2.51814321
170response to lead ion (GO:0010288)2.51808332
171positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.49824113
172organ growth (GO:0035265)2.48451633
173apical protein localization (GO:0045176)2.47439754
174glomerular filtration (GO:0003094)2.44906169
175copper ion homeostasis (GO:0055070)2.44032907
176cellular copper ion homeostasis (GO:0006878)2.41723079
177negative regulation of execution phase of apoptosis (GO:1900118)2.40815873
178neuron fate determination (GO:0048664)2.40143946
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37465691
180virion attachment to host cell (GO:0019062)2.32734914
181adhesion of symbiont to host cell (GO:0044650)2.32734914
182negative regulation of adherens junction organization (GO:1903392)2.32308167
183negative regulation of focal adhesion assembly (GO:0051895)2.32308167
184negative regulation of cell junction assembly (GO:1901889)2.32308167
185regulation of pigment cell differentiation (GO:0050932)2.31538822
186central nervous system myelination (GO:0022010)11.8513980
187axon ensheathment in central nervous system (GO:0032291)11.8513980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45498984
2* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.52126254
3GBX2_23144817_ChIP-Seq_PC3_Human2.49498815
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.41814069
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40248106
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.34265627
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.29282858
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25176955
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19230208
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16981662
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06311302
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04782440
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03918189
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98787767
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97254059
16GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94027069
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93808585
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.93590590
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.91240591
20TAF15_26573619_Chip-Seq_HEK293_Human1.91141442
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90162555
22LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.88970385
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87554964
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86273453
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86273453
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85569964
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83424374
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.76937987
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75685969
30SCL_19346495_ChIP-Seq_HPC-7_Human1.75256221
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75198124
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75198124
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72703380
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71864851
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71844770
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.70658496
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69683958
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69231420
39AR_21572438_ChIP-Seq_LNCaP_Human1.64307678
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62816970
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.62758090
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61632537
43GATA2_19941826_ChIP-Seq_K562_Human1.61527731
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58055464
45VDR_22108803_ChIP-Seq_LS180_Human1.54434368
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52124563
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50701985
48* ER_23166858_ChIP-Seq_MCF-7_Human1.49563366
49BRD4_25478319_ChIP-Seq_HGPS_Human1.49251982
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.47799169
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46721921
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46105217
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44785826
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41281947
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38451867
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38417377
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.36557732
58* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36372895
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35306657
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.33004761
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.32535647
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.32380768
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30571131
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29711980
65* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29523112
66SMAD4_21799915_ChIP-Seq_A2780_Human1.29509289
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.28372951
68BCAT_22108803_ChIP-Seq_LS180_Human1.27560165
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26027277
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25900125
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23050769
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21415517
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20261189
74LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19720000
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19253140
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19203926
77P300_19829295_ChIP-Seq_ESCs_Human1.18193069
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18131085
79AR_25329375_ChIP-Seq_VCAP_Human1.17257186
80EZH2_22144423_ChIP-Seq_EOC_Human1.16989286
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16793036
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16149560
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16136499
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14994243
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14766796
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12785094
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.12652514
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.12335434
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11340849
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10688696
91FUS_26573619_Chip-Seq_HEK293_Human1.09223364
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09153140
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.08900320
94SOX2_20726797_ChIP-Seq_SW620_Human1.06909551
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.06814113
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06075418
97SPI1_23127762_ChIP-Seq_K562_Human1.05511670
98CJUN_26792858_Chip-Seq_BT549_Human1.04953581
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04500057
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03341167
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.03125407
102GATA1_19941826_ChIP-Seq_K562_Human1.01427298
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01255516
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00598774
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00176204
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99525348
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.99284329
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98320344
109EOMES_21245162_ChIP-Seq_HESCs_Human0.97657518
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96882995
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96882995
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96882995
113TP53_16413492_ChIP-PET_HCT116_Human0.96419242
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96338026
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96189079
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95985328
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95757724
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94369719
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93191764
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93187549
121P53_22387025_ChIP-Seq_ESCs_Mouse0.92742135
122CDX2_22108803_ChIP-Seq_LS180_Human0.92664337
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92443786
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92177851
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91953460
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91749934
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.91735867
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91729157
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91275991
130TP63_23658742_ChIP-Seq_EP156T_Human0.90481266
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90299700
132TP53_18474530_ChIP-ChIP_U2OS_Human0.90144199
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90049352
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89752154
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.89396865
136NANOG_19829295_ChIP-Seq_ESCs_Human0.88981443
137SOX2_19829295_ChIP-Seq_ESCs_Human0.88981443
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.88160597
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.86041955
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.85155237
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84964154
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84403056
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.84292741
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83748625
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.83453784
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83310666
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83105291
148HTT_18923047_ChIP-ChIP_STHdh_Human0.83048945
149EWS_26573619_Chip-Seq_HEK293_Human0.81914241
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81088699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.63167940
2MP0003950_abnormal_plasma_membrane4.77659911
3MP0000920_abnormal_myelination4.71555300
4MP0008004_abnormal_stomach_pH4.51230939
5MP0001879_abnormal_lymphatic_vessel3.24917729
6MP0010368_abnormal_lymphatic_system3.22971281
7MP0005171_absent_coat_pigmentation3.22610756
8MP0004147_increased_porphyrin_level3.12538435
9MP0003566_abnormal_cell_adhesion2.87260886
10MP0005409_darkened_coat_color2.80145832
11MP0009379_abnormal_foot_pigmentation2.56623625
12MP0005167_abnormal_blood-brain_barrier2.53630107
13MP0000343_altered_response_to2.51149242
14MP0004272_abnormal_basement_membrane2.47494973
15MP0005623_abnormal_meninges_morphology2.41003071
16MP0003136_yellow_coat_color2.38276262
17MP0003690_abnormal_glial_cell2.36567903
18MP0008438_abnormal_cutaneous_collagen2.01563788
19MP0003880_abnormal_central_pattern2.00015767
20MP0001905_abnormal_dopamine_level1.90404114
21MP0003724_increased_susceptibility_to1.89092545
22MP0004742_abnormal_vestibular_system1.78891343
23MP0002295_abnormal_pulmonary_circulatio1.71791628
24MP0004043_abnormal_pH_regulation1.63858359
25MP0005083_abnormal_biliary_tract1.63517772
26MP0004510_myositis1.62786714
27MP0004142_abnormal_muscle_tone1.62623657
28MP0005408_hypopigmentation1.61451529
29MP0004270_analgesia1.59965215
30MP0003634_abnormal_glial_cell1.59595739
31MP0009697_abnormal_copulation1.59033692
32MP0004036_abnormal_muscle_relaxation1.57640931
33MP0002736_abnormal_nociception_after1.57398599
34MP0005410_abnormal_fertilization1.56797522
35MP0004885_abnormal_endolymph1.54592092
36MP0001486_abnormal_startle_reflex1.53900170
37MP0002877_abnormal_melanocyte_morpholog1.53816106
38MP0001529_abnormal_vocalization1.53581639
39MP0003303_peritoneal_inflammation1.44668991
40MP0003633_abnormal_nervous_system1.43883219
41MP0005423_abnormal_somatic_nervous1.43721996
42MP0000767_abnormal_smooth_muscle1.41797203
43MP0005275_abnormal_skin_tensile1.40395735
44MP0002272_abnormal_nervous_system1.39205829
45MP0003329_amyloid_beta_deposits1.38922648
46MP0005165_increased_susceptibility_to1.38301377
47MP0000465_gastrointestinal_hemorrhage1.37958233
48MP0004381_abnormal_hair_follicle1.37439531
49MP0001485_abnormal_pinna_reflex1.36393671
50MP0000749_muscle_degeneration1.36135270
51MP0003631_nervous_system_phenotype1.34916529
52MP0009384_cardiac_valve_regurgitation1.31276272
53MP0010678_abnormal_skin_adnexa1.31043993
54MP0004484_altered_response_of1.30890177
55MP0000372_irregular_coat_pigmentation1.30648604
56MP0004134_abnormal_chest_morphology1.30162556
57MP0003806_abnormal_nucleotide_metabolis1.29537636
58MP0005595_abnormal_vascular_smooth1.28286800
59MP0000462_abnormal_digestive_system1.27901610
60MP0005164_abnormal_response_to1.26831679
61MP0006054_spinal_hemorrhage1.24024264
62MP0003632_abnormal_nervous_system1.22098530
63MP0003638_abnormal_response/metabolism_1.20833838
64MP0005385_cardiovascular_system_phenoty1.20644018
65MP0001544_abnormal_cardiovascular_syste1.20644018
66MP0002938_white_spotting1.20315412
67MP0001851_eye_inflammation1.17196218
68MP0005084_abnormal_gallbladder_morpholo1.15638134
69MP0000383_abnormal_hair_follicle1.15571963
70MP0000762_abnormal_tongue_morphology1.13498802
71MP0004130_abnormal_muscle_cell1.13449057
72MP0003091_abnormal_cell_migration1.12269682
73MP0001958_emphysema1.10959265
74MP0001915_intracranial_hemorrhage1.10827078
75MP0006138_congestive_heart_failure1.10453727
76MP0003279_aneurysm1.10222553
77MP0005023_abnormal_wound_healing1.09617788
78MP0005551_abnormal_eye_electrophysiolog1.08729460
79MP0010030_abnormal_orbit_morphology1.07843036
80MP0003011_delayed_dark_adaptation1.01117484
81MP0002229_neurodegeneration1.00988503
82MP0001346_abnormal_lacrimal_gland1.00666154
83MP0000778_abnormal_nervous_system1.00511872
84MP0003195_calcinosis0.99802676
85MP0005330_cardiomyopathy0.97722518
86MP0005187_abnormal_penis_morphology0.96673539
87MP0004084_abnormal_cardiac_muscle0.95611533
88MP0009250_abnormal_appendicular_skeleto0.95006015
89MP0004145_abnormal_muscle_electrophysio0.93033796
90MP0006276_abnormal_autonomic_nervous0.91616288
91MP0000747_muscle_weakness0.90127957
92MP0001614_abnormal_blood_vessel0.90064983
93MP0005195_abnormal_posterior_eye0.89901969
94MP0009053_abnormal_anal_canal0.89816808
95MP0004215_abnormal_myocardial_fiber0.89265160
96MP0002133_abnormal_respiratory_system0.88864712
97MP0005388_respiratory_system_phenotype0.88864712
98MP0002064_seizures0.88312849
99MP0002972_abnormal_cardiac_muscle0.88067647
100MP0005058_abnormal_lysosome_morphology0.86565608
101MP0005451_abnormal_body_composition0.86502784
102MP0008260_abnormal_autophagy0.85576102
103MP0004085_abnormal_heartbeat0.84114799
104MP0005620_abnormal_muscle_contractility0.83906513
105MP0003137_abnormal_impulse_conducting0.83141814
106MP0002009_preneoplasia0.83115189
107MP0009780_abnormal_chondrocyte_physiolo0.82963671
108MP0005670_abnormal_white_adipose0.82790304
109MP0001661_extended_life_span0.82151538
110MP0003828_pulmonary_edema0.81452742
111MP0005503_abnormal_tendon_morphology0.81227454
112MP0008569_lethality_at_weaning0.80491354
113MP0001542_abnormal_bone_strength0.78488809
114MP0000647_abnormal_sebaceous_gland0.77848683
115MP0000230_abnormal_systemic_arterial0.75923392
116MP0004883_abnormal_blood_vessel0.74905291
117MP0002249_abnormal_larynx_morphology0.74457761
118MP0008872_abnormal_physiological_respon0.74181530
119MP0002108_abnormal_muscle_morphology0.72675506
120MP0001663_abnormal_digestive_system0.72125850
121MP0010329_abnormal_lipoprotein_level0.71645861
122MP0001963_abnormal_hearing_physiology0.71284831
123MP0003186_abnormal_redox_activity0.71251459
124MP0009764_decreased_sensitivity_to0.70802314
125MP0005508_abnormal_skeleton_morphology0.68576664
126MP0008874_decreased_physiological_sensi0.67974407
127MP0003938_abnormal_ear_development0.67640600
128MP0008775_abnormal_heart_ventricle0.66568404
129MP0002332_abnormal_exercise_endurance0.66349975
130MP0000249_abnormal_blood_vessel0.66051267
131MP0000163_abnormal_cartilage_morphology0.64836975
132MP0002127_abnormal_cardiovascular_syste0.64580111
133MP0002925_abnormal_cardiovascular_devel0.63523470
134MP0003705_abnormal_hypodermis_morpholog0.62897141
135MP0002128_abnormal_blood_circulation0.62762613
136MP0002734_abnormal_mechanical_nocicepti0.62689379
137MP0002933_joint_inflammation0.62400059
138MP0001188_hyperpigmentation0.62136424
139MP0001784_abnormal_fluid_regulation0.60981459
140MP0000358_abnormal_cell_content/0.60804544
141MP0000049_abnormal_middle_ear0.60115441
142MP0000858_altered_metastatic_potential0.59929312
143MP0002733_abnormal_thermal_nociception0.57988469
144MP0009763_increased_sensitivity_to0.57492971
145MP0001968_abnormal_touch/_nociception0.57149774
146MP0005390_skeleton_phenotype0.56081338
147MP0003300_gastrointestinal_ulcer0.55805726
148MP0005248_abnormal_Harderian_gland0.55733615
149MP0001533_abnormal_skeleton_physiology0.53726922
150MP0010155_abnormal_intestine_physiology0.53252287
151MP0002138_abnormal_hepatobiliary_system0.51257221
152MP0000015_abnormal_ear_pigmentation0.48206245
153MP0002132_abnormal_respiratory_system0.47703154
154MP0003448_altered_tumor_morphology0.46933795
155MP0005666_abnormal_adipose_tissue0.46464574
156MP0002113_abnormal_skeleton_development0.45374309
157MP0005085_abnormal_gallbladder_physiolo0.44539763

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.60025277
2Increased mean platelet volume (HP:0011877)9.58204213
3Abnormal platelet volume (HP:0011876)8.78436303
4Petechiae (HP:0000967)7.79582380
5Purpura (HP:0000979)7.12624093
6Epistaxis (HP:0000421)6.51438490
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.65271114
8Degeneration of the lateral corticospinal tracts (HP:0002314)5.65271114
9Neurofibrillary tangles (HP:0002185)5.61176445
10Spontaneous hematomas (HP:0007420)5.53157611
11Abnormal platelet function (HP:0011869)5.32654760
12Impaired platelet aggregation (HP:0003540)5.32654760
13Conjunctival telangiectasia (HP:0000524)5.25445283
14Gingival bleeding (HP:0000225)4.63857050
15Abnormality of the vasculature of the conjunctiva (HP:0008054)4.30423591
16Dyschromatopsia (HP:0007641)4.10543535
17Parakeratosis (HP:0001036)4.09804441
18Onion bulb formation (HP:0003383)3.88747905
19Peripheral hypomyelination (HP:0007182)3.86952314
20Cerebral hemorrhage (HP:0001342)3.75153576
21Cerebral inclusion bodies (HP:0100314)3.66713377
22Abnormality of the corticospinal tract (HP:0002492)3.61021952
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.54463081
24Segmental peripheral demyelination/remyelination (HP:0003481)3.46123116
25Polycythemia (HP:0001901)3.29485417
26Retinal dysplasia (HP:0007973)3.27766458
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.25365577
28Aortic aneurysm (HP:0004942)3.21806885
29Hypoplasia of the iris (HP:0007676)3.14355979
30Bruising susceptibility (HP:0000978)3.13528544
31Abnormality of glycolysis (HP:0004366)3.06673333
32Increased serum pyruvate (HP:0003542)3.06673333
33Stridor (HP:0010307)3.06633076
34Abnormal auditory evoked potentials (HP:0006958)3.06567507
35Abnormal pupillary function (HP:0007686)3.03055159
36Myocardial infarction (HP:0001658)3.01435824
37Leukodystrophy (HP:0002415)2.93148804
38Stenosis of the external auditory canal (HP:0000402)2.92541552
39Aortic dissection (HP:0002647)2.90828542
40Insidious onset (HP:0003587)2.89693902
41Termporal pattern (HP:0011008)2.89693902
42Increased density of long bones (HP:0006392)2.88378913
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.88052036
44Muscle fiber splitting (HP:0003555)2.88037030
45Scanning speech (HP:0002168)2.85258152
46Acanthocytosis (HP:0001927)2.80229731
47Sensory axonal neuropathy (HP:0003390)2.77815406
48Poikilocytosis (HP:0004447)2.70354574
49Short hallux (HP:0010109)2.69748703
50Renal Fanconi syndrome (HP:0001994)2.61935272
51Patchy hypopigmentation of hair (HP:0011365)2.61790596
52Abnormality of the common coagulation pathway (HP:0010990)2.59842509
53Protrusio acetabuli (HP:0003179)2.59460552
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57969218
55Anteriorly placed anus (HP:0001545)2.53671878
56Diaphragmatic weakness (HP:0009113)2.53193481
57Supranuclear gaze palsy (HP:0000605)2.52430230
58Premature skin wrinkling (HP:0100678)2.51083258
59Axonal loss (HP:0003447)2.48166477
60Clumsiness (HP:0002312)2.44544017
61Aplasia/Hypoplasia of the hallux (HP:0008362)2.42811044
62Metabolic alkalosis (HP:0200114)2.39387700
63Tetraparesis (HP:0002273)2.37150280
64White forelock (HP:0002211)2.37004488
65Ankle clonus (HP:0011448)2.34542510
66Slow saccadic eye movements (HP:0000514)2.34133118
67Cerebral hypomyelination (HP:0006808)2.31222804
68Acute necrotizing encephalopathy (HP:0006965)2.30968499
69Congenital ichthyosiform erythroderma (HP:0007431)2.27867276
70Absent septum pellucidum (HP:0001331)2.26496665
71Broad metatarsal (HP:0001783)2.25325553
72Hypoplastic left heart (HP:0004383)2.24258988
73Spastic gait (HP:0002064)2.23679524
74Hematochezia (HP:0002573)2.21060111
75Joint hemorrhage (HP:0005261)2.19026710
76Vascular tortuosity (HP:0004948)2.18580284
77Hepatosplenomegaly (HP:0001433)2.18394127
78Foot dorsiflexor weakness (HP:0009027)2.18160699
79Alacrima (HP:0000522)2.17858548
80Esophageal atresia (HP:0002032)2.17804751
81Partial duplication of thumb phalanx (HP:0009944)2.17793962
823-Methylglutaconic aciduria (HP:0003535)2.17136962
83Nausea (HP:0002018)2.17082703
84Mitral stenosis (HP:0001718)2.16600712
85Intention tremor (HP:0002080)2.15087105
86Autoamputation (HP:0001218)2.14995001
87Thickened helices (HP:0000391)2.14883315
88Coronal craniosynostosis (HP:0004440)2.14371399
89Spinal rigidity (HP:0003306)2.13998117
90Premature rupture of membranes (HP:0001788)2.13707142
91Arterial tortuosity (HP:0005116)2.13245419
92Infantile muscular hypotonia (HP:0008947)2.12118469
93Dysmetria (HP:0001310)2.11607883
94Gowers sign (HP:0003391)2.11036940
95Hypokalemic alkalosis (HP:0001949)2.10666113
96Hyporeflexia of lower limbs (HP:0002600)2.09180314
97Dysautonomia (HP:0002459)2.07520645
98Hypomagnesemia (HP:0002917)2.07374819
99Paralysis (HP:0003470)2.06454608
100Abnormality of the middle phalanges of the toes (HP:0010183)2.06402356
101Mucosal telangiectasiae (HP:0100579)2.05937748
102Methylmalonic acidemia (HP:0002912)2.05134603
103Aplasia of the phalanges of the hand (HP:0009802)2.03778143
104Aplasia involving bones of the extremities (HP:0009825)2.03778143
105Aplasia involving bones of the upper limbs (HP:0009823)2.03778143
106Hemiparesis (HP:0001269)2.03422304
107Xanthomatosis (HP:0000991)2.03259920
108Abnormality of the foot musculature (HP:0001436)2.01087899
109Decreased central vision (HP:0007663)2.00609977
110Menorrhagia (HP:0000132)10.0838036
111Acute encephalopathy (HP:0006846)1.98613374
112Partial duplication of the phalanx of hand (HP:0009999)1.98523541
113Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98418671
114Portal hypertension (HP:0001409)1.98105589
115Pulmonary artery stenosis (HP:0004415)1.94175596
116Abnormality of lateral ventricle (HP:0030047)1.93689374
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.93625121
118Upper limb muscle weakness (HP:0003484)1.93477662
119Increased circulating renin level (HP:0000848)1.91311660
120Ankyloglossia (HP:0010296)1.91153334
121Mitochondrial inheritance (HP:0001427)1.89932451
122Abnormality of skeletal muscle fiber size (HP:0012084)1.89543634
123Congenital, generalized hypertrichosis (HP:0004540)1.89284677
124Ileus (HP:0002595)1.88574004
125Abnormality of the axillary hair (HP:0100134)1.87405004
126Abnormality of secondary sexual hair (HP:0009888)1.87405004
127Confusion (HP:0001289)1.87181937
128Hyperlipoproteinemia (HP:0010980)1.86941994
129Buphthalmos (HP:0000557)1.86660577
130Steppage gait (HP:0003376)1.86460497
131Spastic paraparesis (HP:0002313)1.86370145
132Exertional dyspnea (HP:0002875)1.86349297
133Progressive macrocephaly (HP:0004481)1.84682803
134Increased variability in muscle fiber diameter (HP:0003557)1.84534878
135Split foot (HP:0001839)1.84384747
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.83586929
137Hypoplasia of the fovea (HP:0007750)1.83586929
138Hammertoe (HP:0001765)1.83196188
139Abnormality of the septum pellucidum (HP:0007375)1.83168679
140Morphological abnormality of the inner ear (HP:0011390)1.82030591
141Pancreatic islet-cell hyperplasia (HP:0004510)1.80702177
142Hypoplastic pelvis (HP:0008839)1.80582378
143Prolonged neonatal jaundice (HP:0006579)1.80553632
144CNS hypomyelination (HP:0003429)1.79787988
145Muscle hypertrophy of the lower extremities (HP:0008968)1.79749034
146Abnormality of the fovea (HP:0000493)1.79318622
147Hepatocellular necrosis (HP:0001404)1.77938929
148Back pain (HP:0003418)1.76776373
149Nonprogressive disorder (HP:0003680)1.76426813
150Hypoplastic heart (HP:0001961)1.76209256
151Abnormality of the hepatic vasculature (HP:0006707)1.76120266
152Biliary tract neoplasm (HP:0100574)1.75537969
153Generalized aminoaciduria (HP:0002909)1.70462481
154Venous insufficiency (HP:0005293)1.69420191
155Scotoma (HP:0000575)1.68568982
156Testicular neoplasm (HP:0010788)1.65659015
157Soft skin (HP:0000977)1.60621477
158Gonadal dysgenesis (HP:0000133)1.58942439
159Abnormality of oral frenula (HP:0000190)1.56517590
160Congenital sensorineural hearing impairment (HP:0008527)1.52826992
161Cardiovascular calcification (HP:0011915)1.52776503
162Peritonitis (HP:0002586)1.50845156
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.50404548
164Neoplasm of the rectum (HP:0100743)1.48421962
165Thyroid-stimulating hormone excess (HP:0002925)1.48361633
166Hypophosphatemic rickets (HP:0004912)1.48038022
167Venous abnormality (HP:0002624)1.46830618
168Spontaneous abortion (HP:0005268)1.46648853
169Choroideremia (HP:0001139)1.46141930
170Esophageal varix (HP:0002040)1.45965199
171Muscle fibrillation (HP:0010546)1.45703634
172Blue sclerae (HP:0000592)1.45199611
173Renal tubular acidosis (HP:0001947)1.41269328
174Follicular hyperkeratosis (HP:0007502)1.39140933
175Disproportionate short-trunk short stature (HP:0003521)1.38802716
176Abnormal ciliary motility (HP:0012262)1.38342832
177Abnormal autonomic nervous system physiology (HP:0012332)1.38088118
178Uterine leiomyosarcoma (HP:0002891)1.37365967
179Leiomyosarcoma (HP:0100243)1.37365967
180Vascular calcification (HP:0004934)1.36781757
181Aplasia/Hypoplasia affecting the retina (HP:0008061)1.36029653
182Papillary thyroid carcinoma (HP:0002895)1.35552483
183Aplasia/Hypoplasia of the macula (HP:0008059)1.35393006
184Distal lower limb amyotrophy (HP:0008944)1.34886968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.75458436
2MAPKAPK53.94121710
3TIE13.82310797
4EPHB13.66427503
5OXSR13.59903962
6BMX2.73665179
7KDR2.66691767
8PBK2.64516194
9PKN12.53546679
10EIF2AK12.40320584
11RIPK42.28219809
12FGFR22.20217904
13MST42.18361960
14MUSK2.16745176
15MAP3K122.09713656
16MET2.09485088
17GRK52.08162945
18PLK22.00868646
19STK101.96636275
20WNK41.93083746
21TESK21.85370714
22BCR1.80614136
23ADRBK11.72046563
24FER1.69399050
25CLK11.65881642
26BTK1.53106626
27TRIM281.52999300
28GRK11.47241416
29MYLK1.45367900
30LIMK11.44529210
31ZAP701.38981909
32SIK31.38104286
33CAMK2B1.37211513
34MAPKAPK31.35022197
35CSNK1G31.33254704
36FGR1.30145486
37CSNK1A1L1.29849366
38UHMK11.29471791
39ROCK21.27806309
40LRRK21.26199852
41TGFBR11.24752400
42BMPR21.24620230
43CAMK2D1.24389370
44PTK2B1.24156883
45STK31.23552249
46ROCK11.23508885
47WNK11.18221043
48PRKD11.18113614
49CDK191.17850597
50NTRK11.15763254
51ACVR1B1.14592530
52BMPR1B1.13577171
53DYRK21.09461634
54CSNK1G11.06861223
55MAPK151.06708289
56TNIK1.04509879
57NEK61.04191485
58PIK3CA1.04141838
59MARK21.03402033
60MAP2K21.01575269
61PRKG21.01202547
62TGFBR20.98986147
63ARAF0.97897154
64CSF1R0.93908626
65CAMK2G0.92504800
66MKNK10.91071240
67CASK0.89747513
68SGK2230.88602874
69SGK4940.88602874
70CSNK1G20.86597450
71PAK20.86326416
72PRKCE0.84625882
73PAK30.84438597
74PNCK0.84200751
75CAMK2A0.80087942
76TESK10.80032633
77GRK60.79850712
78MAPK120.79074077
79RPS6KA50.76669972
80SYK0.75826809
81PTK20.75030767
82PIM20.74769654
83HCK0.74360935
84LMTK20.73795871
85TRPM70.72327616
86CSK0.68882985
87ERBB40.66239401
88PRKD20.65540877
89OBSCN0.64998844
90GSK3A0.64866177
91NUAK10.63912740
92PRKG10.62546572
93DAPK30.62525150
94MAP2K30.62357003
95CDK80.61785249
96PRKCQ0.60212087
97MAP3K30.58250020
98CAMK1G0.58135756
99MAP2K10.58042931
100YES10.57688873
101PRKACB0.56280473
102PHKG10.56225520
103PHKG20.56225520
104DMPK0.55637573
105PAK40.53823374
106ERBB30.52880858
107NEK90.52673079
108ILK0.51851200
109KIT0.51154719
110MINK10.50812916
111MAPK130.50480784
112TLK10.50462005
113IRAK10.47590495
114IGF1R0.46794861
115INSRR0.46589480
116MAPK70.46479299
117FLT30.45968210
118INSR0.44931583
119PLK30.43427164
120ITK0.43213905
121NLK0.42789781
122CDK140.42129480
123MAP3K50.41925159
124ERBB20.40940280
125ADRBK20.40699538
126WEE10.40467111
127PIK3CG0.40362590
128TAOK30.39867119
129NME20.39477411
130LYN0.39435052
131CDK50.38847519
132GRK70.38488887
133DYRK30.37624699
134DDR20.37270173
135BRSK20.36751654
136FYN0.36581766
137EPHB20.36466055
138MAPK40.36103323
139PDPK10.35650895
140VRK10.35096453
141MARK30.35057035
142PRKACG0.33417251
143CAMK10.33103751
144PRKAA20.32684958
145TEC0.32639415
146PDGFRA0.32547689
147MOS0.31840915
148PAK10.31584780
149AKT30.31189886
150ABL20.31162394
151PRKACA0.30364310
152CDK150.30088924
153PDGFRB0.29943527
154FES0.28692964
155SRC0.28657416
156CDK11A0.27684497

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.01010102
2Fatty acid elongation_Homo sapiens_hsa000624.88743252
3Steroid biosynthesis_Homo sapiens_hsa001003.73561854
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.54759541
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99054481
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.96152601
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95807091
8Ether lipid metabolism_Homo sapiens_hsa005652.83592322
9Protein export_Homo sapiens_hsa030602.56075975
10Oxidative phosphorylation_Homo sapiens_hsa001902.22132942
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18744764
12Histidine metabolism_Homo sapiens_hsa003402.18600695
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.18103471
14Sulfur metabolism_Homo sapiens_hsa009201.90918546
15Parkinsons disease_Homo sapiens_hsa050121.90201746
16Nitrogen metabolism_Homo sapiens_hsa009101.81507190
17Sphingolipid metabolism_Homo sapiens_hsa006001.73322092
18Hematopoietic cell lineage_Homo sapiens_hsa046401.72517210
19Linoleic acid metabolism_Homo sapiens_hsa005911.72384712
20Alzheimers disease_Homo sapiens_hsa050101.63064350
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57987755
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57459282
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54615438
24Ribosome_Homo sapiens_hsa030101.46073294
25Shigellosis_Homo sapiens_hsa051311.44658641
26Collecting duct acid secretion_Homo sapiens_hsa049661.40644047
27Arginine and proline metabolism_Homo sapiens_hsa003301.30471731
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26129237
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.25516214
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21921022
31Arachidonic acid metabolism_Homo sapiens_hsa005901.20345151
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18440977
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17716347
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17619555
35Cardiac muscle contraction_Homo sapiens_hsa042601.16450434
36Vitamin B6 metabolism_Homo sapiens_hsa007501.13842976
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13639324
38TGF-beta signaling pathway_Homo sapiens_hsa043501.13012924
39Glycerolipid metabolism_Homo sapiens_hsa005611.12839495
40Small cell lung cancer_Homo sapiens_hsa052221.11584693
41Axon guidance_Homo sapiens_hsa043601.10989650
42ECM-receptor interaction_Homo sapiens_hsa045121.10414295
43Butanoate metabolism_Homo sapiens_hsa006501.07186815
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.02825285
45Adherens junction_Homo sapiens_hsa045201.02820958
46Ovarian steroidogenesis_Homo sapiens_hsa049131.02093444
47Amoebiasis_Homo sapiens_hsa051461.01434716
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98840923
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98077194
50Vitamin digestion and absorption_Homo sapiens_hsa049770.97165835
51Mineral absorption_Homo sapiens_hsa049780.96069712
52Tight junction_Homo sapiens_hsa045300.95197652
53* Chemokine signaling pathway_Homo sapiens_hsa040620.94564471
54Huntingtons disease_Homo sapiens_hsa050160.93128571
55Renal cell carcinoma_Homo sapiens_hsa052110.92001928
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90957434
57* Alcoholism_Homo sapiens_hsa050340.87902536
58Complement and coagulation cascades_Homo sapiens_hsa046100.86267048
59Olfactory transduction_Homo sapiens_hsa047400.86157350
60Propanoate metabolism_Homo sapiens_hsa006400.84943586
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.84061408
62Phagosome_Homo sapiens_hsa041450.83996549
63Proteoglycans in cancer_Homo sapiens_hsa052050.82976487
64* Ras signaling pathway_Homo sapiens_hsa040140.82162600
65PPAR signaling pathway_Homo sapiens_hsa033200.79293649
66Glutathione metabolism_Homo sapiens_hsa004800.77669372
67* Pathways in cancer_Homo sapiens_hsa052000.77408250
68Renin-angiotensin system_Homo sapiens_hsa046140.75435596
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74859505
70* Serotonergic synapse_Homo sapiens_hsa047260.74509465
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.74093038
72Long-term depression_Homo sapiens_hsa047300.73367740
73Fatty acid metabolism_Homo sapiens_hsa012120.72080106
74Malaria_Homo sapiens_hsa051440.71337781
75Rheumatoid arthritis_Homo sapiens_hsa053230.69248029
76Systemic lupus erythematosus_Homo sapiens_hsa053220.68900431
77Dilated cardiomyopathy_Homo sapiens_hsa054140.68658866
78Folate biosynthesis_Homo sapiens_hsa007900.67870149
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67085874
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66976805
81Melanoma_Homo sapiens_hsa052180.65832458
82Pancreatic cancer_Homo sapiens_hsa052120.63981100
83Rap1 signaling pathway_Homo sapiens_hsa040150.63761385
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61472541
85Calcium signaling pathway_Homo sapiens_hsa040200.60781880
86* Glutamatergic synapse_Homo sapiens_hsa047240.59573515
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59475984
88Chemical carcinogenesis_Homo sapiens_hsa052040.57118243
89Mismatch repair_Homo sapiens_hsa034300.56932326
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56742628
91* GABAergic synapse_Homo sapiens_hsa047270.55429808
92Focal adhesion_Homo sapiens_hsa045100.55128817
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54951632
94Hippo signaling pathway_Homo sapiens_hsa043900.54272529
95Dorso-ventral axis formation_Homo sapiens_hsa043200.54158089
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.53634868
97Platelet activation_Homo sapiens_hsa046110.51198324
98Autoimmune thyroid disease_Homo sapiens_hsa053200.51107867
99beta-Alanine metabolism_Homo sapiens_hsa004100.50928434
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.50564412
101Renin secretion_Homo sapiens_hsa049240.49999382
102Salmonella infection_Homo sapiens_hsa051320.49783755
103* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48881636
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46359390
105Salivary secretion_Homo sapiens_hsa049700.46349007
106African trypanosomiasis_Homo sapiens_hsa051430.44424775
107Cocaine addiction_Homo sapiens_hsa050300.42305920
108Metabolic pathways_Homo sapiens_hsa011000.41958531
109Gastric acid secretion_Homo sapiens_hsa049710.41831918
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41734499
111Pancreatic secretion_Homo sapiens_hsa049720.41533456
112Gap junction_Homo sapiens_hsa045400.39876722
113Endocytosis_Homo sapiens_hsa041440.38792724
114Retinol metabolism_Homo sapiens_hsa008300.38215488
115ABC transporters_Homo sapiens_hsa020100.37976377
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37022110
117Vibrio cholerae infection_Homo sapiens_hsa051100.36527805
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36347764
119Peroxisome_Homo sapiens_hsa041460.36339680
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36159233
121Basal cell carcinoma_Homo sapiens_hsa052170.35906842
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35598247
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35452833
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35151177
125Starch and sucrose metabolism_Homo sapiens_hsa005000.34716756
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34318978
127Fat digestion and absorption_Homo sapiens_hsa049750.33811071
128Bile secretion_Homo sapiens_hsa049760.33684629
129Phototransduction_Homo sapiens_hsa047440.31871789
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.31679642
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30862346
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30409540
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30218413
134Regulation of autophagy_Homo sapiens_hsa041400.30049708
135HIF-1 signaling pathway_Homo sapiens_hsa040660.29955428
136* Circadian entrainment_Homo sapiens_hsa047130.29805513
137* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29629824
138Choline metabolism in cancer_Homo sapiens_hsa052310.29538642
139Hedgehog signaling pathway_Homo sapiens_hsa043400.28993820
140Tyrosine metabolism_Homo sapiens_hsa003500.28914431
141* Morphine addiction_Homo sapiens_hsa050320.28570929
142Melanogenesis_Homo sapiens_hsa049160.25471210
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24395244

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