GNG12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.73803352
2COPI coating of Golgi vesicle (GO:0048205)8.73803352
3signal peptide processing (GO:0006465)5.93944921
4endocrine pancreas development (GO:0031018)5.78143575
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.65733588
6protein maturation by protein folding (GO:0022417)5.61782107
7COPII vesicle coating (GO:0048208)5.48476937
8peptide hormone processing (GO:0016486)5.29333814
9sequestering of metal ion (GO:0051238)5.24013762
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.09226317
11cell adhesion mediated by integrin (GO:0033627)4.95704529
12protein retention in ER lumen (GO:0006621)4.88141730
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.77064003
14hemidesmosome assembly (GO:0031581)4.64650442
15type B pancreatic cell development (GO:0003323)4.61223559
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.54252475
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.54093887
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.49336623
19ER overload response (GO:0006983)4.47015443
20desmosome organization (GO:0002934)4.46097081
21response to hepatocyte growth factor (GO:0035728)4.39813994
22cellular response to hepatocyte growth factor stimulus (GO:0035729)4.39813994
23cellular response to vitamin D (GO:0071305)4.37677079
24skin morphogenesis (GO:0043589)4.32239825
25positive regulation of nuclease activity (GO:0032075)4.26938847
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.11462203
27ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.00464865
28glandular epithelial cell differentiation (GO:0002067)3.98990367
29collagen fibril organization (GO:0030199)3.95510082
30chondrocyte proliferation (GO:0035988)3.95175839
31endoplasmic reticulum unfolded protein response (GO:0030968)3.89741107
32endodermal cell differentiation (GO:0035987)3.87885076
33vesicle coating (GO:0006901)3.87381055
34regulation of nuclease activity (GO:0032069)3.84728247
35glandular epithelial cell development (GO:0002068)3.83259598
36sequestering of extracellular ligand from receptor (GO:0035581)3.78434634
37cellular response to unfolded protein (GO:0034620)3.78321355
38ER-nucleus signaling pathway (GO:0006984)3.66682262
39cellular response to topologically incorrect protein (GO:0035967)3.62709379
40retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62072347
41exocrine pancreas development (GO:0031017)3.57462340
42negative regulation of chondrocyte differentiation (GO:0032331)3.49648694
43magnesium ion transport (GO:0015693)3.46571753
44response to lipoprotein particle (GO:0055094)3.45772737
45protein N-linked glycosylation via asparagine (GO:0018279)3.43336109
46cellular response to vitamin (GO:0071295)3.40394999
47peptidyl-asparagine modification (GO:0018196)3.39265510
48regulation of transforming growth factor beta2 production (GO:0032909)3.38369855
49ER to Golgi vesicle-mediated transport (GO:0006888)3.34808350
50endothelial cell morphogenesis (GO:0001886)3.33869941
51cell-substrate junction assembly (GO:0007044)3.30161437
52protein heterotrimerization (GO:0070208)3.28336655
53fatty acid elongation (GO:0030497)3.26577485
54protein N-linked glycosylation (GO:0006487)3.26474670
55axon ensheathment in central nervous system (GO:0032291)3.24620598
56central nervous system myelination (GO:0022010)3.24620598
57positive regulation of insulin secretion (GO:0032024)3.22641688
58wound healing, spreading of epidermal cells (GO:0035313)3.22330578
59long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.21632594
60response to redox state (GO:0051775)3.20541231
61actin filament depolymerization (GO:0030042)3.20227784
62protein localization to endosome (GO:0036010)3.19379593
63response to endoplasmic reticulum stress (GO:0034976)3.18664788
64nucleotide transmembrane transport (GO:1901679)3.17122676
65insulin secretion (GO:0030073)3.16772446
66regulation of transforming growth factor beta1 production (GO:0032908)3.15893415
67amyloid precursor protein catabolic process (GO:0042987)3.15651101
68mesenchymal-epithelial cell signaling (GO:0060638)3.14576008
69epithelial cell-cell adhesion (GO:0090136)3.08639581
70kidney mesenchyme development (GO:0072074)3.08265152
71substrate-dependent cell migration (GO:0006929)3.07076325
72membrane protein ectodomain proteolysis (GO:0006509)3.05920580
73toxin metabolic process (GO:0009404)3.04793349
74astrocyte differentiation (GO:0048708)3.03932735
75negative regulation of glycoprotein biosynthetic process (GO:0010561)3.03196275
76type B pancreatic cell proliferation (GO:0044342)3.00326360
77columnar/cuboidal epithelial cell development (GO:0002066)2.99344787
78purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.98574196
793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.98574196
80cholesterol biosynthetic process (GO:0006695)2.98423531
81interleukin-1-mediated signaling pathway (GO:0070498)2.98074675
82virion attachment to host cell (GO:0019062)2.97088847
83adhesion of symbiont to host cell (GO:0044650)2.97088847
84extracellular fibril organization (GO:0043206)2.96536157
85negative regulation of fatty acid transport (GO:2000192)2.95461684
86regulation of insulin secretion (GO:0050796)2.92625925
87cell migration involved in sprouting angiogenesis (GO:0002042)2.91861387
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.91284042
89response to unfolded protein (GO:0006986)2.90854697
90regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.90165958
91intestinal absorption (GO:0050892)2.88968551
92peptidyl-proline hydroxylation (GO:0019511)2.88442158
934-hydroxyproline metabolic process (GO:0019471)2.87867278
94barbed-end actin filament capping (GO:0051016)2.85865991
95paraxial mesoderm development (GO:0048339)2.83373321
96mesodermal cell differentiation (GO:0048333)2.83174309
97protein hydroxylation (GO:0018126)2.82734571
98cell migration involved in heart development (GO:0060973)2.81272605
99hippo signaling (GO:0035329)2.80948669
100Golgi organization (GO:0007030)2.80923235
101response to topologically incorrect protein (GO:0035966)2.80536855
102peptidyl-tyrosine autophosphorylation (GO:0038083)2.80340504
103gap junction assembly (GO:0016264)2.79874206
104basement membrane organization (GO:0071711)2.79445025
105positive regulation of osteoblast proliferation (GO:0033690)2.79380750
106substrate adhesion-dependent cell spreading (GO:0034446)2.79050547
107regulation of integrin-mediated signaling pathway (GO:2001044)2.78701638
108fatty-acyl-CoA biosynthetic process (GO:0046949)2.78339930
109vascular endothelial growth factor signaling pathway (GO:0038084)2.78330148
110negative regulation of anoikis (GO:2000811)2.76708077
111dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76676113
112multicellular organismal macromolecule metabolic process (GO:0044259)2.76099154
113muscle cell migration (GO:0014812)2.74193997
114collagen metabolic process (GO:0032963)2.73223202
115sphingosine metabolic process (GO:0006670)2.72463126
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.71939347
117extracellular matrix assembly (GO:0085029)2.71268487
118hypotonic response (GO:0006971)2.71234971
119positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71170235
120peptide metabolic process (GO:0006518)2.71088931
121multicellular organismal metabolic process (GO:0044236)2.70818719
122negative regulation of neurotransmitter secretion (GO:0046929)2.70771681
123gland morphogenesis (GO:0022612)2.70510267
124intra-Golgi vesicle-mediated transport (GO:0006891)2.69726612
125regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.69359356
126negative regulation of insulin secretion (GO:0046676)2.67393519
127eye photoreceptor cell differentiation (GO:0001754)2.65607065
128photoreceptor cell differentiation (GO:0046530)2.65607065
129midgut development (GO:0007494)2.65175807
130metanephric mesenchyme development (GO:0072075)2.65056554
131macroautophagy (GO:0016236)2.64964412
132regulation of peptide hormone secretion (GO:0090276)2.64594707
133membrane raft organization (GO:0031579)2.64163347
134smooth muscle tissue development (GO:0048745)2.62777296
135eosinophil chemotaxis (GO:0048245)2.62619878
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62303210
137renal filtration (GO:0097205)2.62111607
138axon ensheathment (GO:0008366)2.61920540
139ensheathment of neurons (GO:0007272)2.61920540
140negative regulation of norepinephrine secretion (GO:0010700)2.61345976
141glycosylceramide metabolic process (GO:0006677)2.60528972
142regulation of peptide secretion (GO:0002791)2.59289629
143negative regulation of keratinocyte proliferation (GO:0010839)2.59250370
144sterol biosynthetic process (GO:0016126)2.58829436
145Golgi vesicle transport (GO:0048193)2.58262014
146amyloid precursor protein metabolic process (GO:0042982)2.57918607
147extracellular matrix disassembly (GO:0022617)2.57809590
148wound healing, spreading of cells (GO:0044319)2.57516615
149protein localization to cell surface (GO:0034394)2.57012941
150long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56533447
151myelination (GO:0042552)2.56275152
152regulation of metalloenzyme activity (GO:0048552)2.56053888
153nitric oxide mediated signal transduction (GO:0007263)2.56029251
154fibril organization (GO:0097435)2.55624176
155lymphangiogenesis (GO:0001946)2.55293417
156negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.55176871
157regulation of early endosome to late endosome transport (GO:2000641)2.54853668
158negative regulation of glycoprotein metabolic process (GO:1903019)2.53815989
159myelin maintenance (GO:0043217)2.53198039
160multicellular organismal catabolic process (GO:0044243)2.52889053
161negative regulation of stem cell proliferation (GO:2000647)2.52805053
162glomerular visceral epithelial cell development (GO:0072015)2.52490431
163regulation of plasminogen activation (GO:0010755)2.52382561
164nucleotide-sugar biosynthetic process (GO:0009226)2.51913892
165hormone catabolic process (GO:0042447)2.51605042
166positive regulation of peptide hormone secretion (GO:0090277)2.49846332
167oligodendrocyte differentiation (GO:0048709)2.49439647
168glomerular basement membrane development (GO:0032836)2.48580003
169collagen catabolic process (GO:0030574)2.48449752
170regulation of Golgi to plasma membrane protein transport (GO:0042996)2.46910995
171leukocyte migration involved in inflammatory response (GO:0002523)2.46345701
172regulation of extracellular matrix disassembly (GO:0010715)2.45906586
173creatine metabolic process (GO:0006600)2.45122532
174nucleoside diphosphate catabolic process (GO:0009134)2.43669326
175apoptotic cell clearance (GO:0043277)2.42988636
176regulation of chondrocyte differentiation (GO:0032330)2.42663196
177regulation of cardioblast differentiation (GO:0051890)2.42194079
178extracellular matrix organization (GO:0030198)2.40787210
179negative regulation of cartilage development (GO:0061037)2.40492535
180extracellular structure organization (GO:0043062)2.39842105
181adherens junction assembly (GO:0034333)2.39835572
182stress fiber assembly (GO:0043149)2.38509176
183axon extension involved in axon guidance (GO:0048846)2.38444863
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.38444863
185regulation of anoikis (GO:2000209)2.37427404
186vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35416848
187bundle of His cell to Purkinje myocyte communication (GO:0086069)2.35145371
188negative regulation of protein localization to plasma membrane (GO:1903077)2.32791663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.76574485
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.54556790
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.17618478
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.70672679
5AR_21909140_ChIP-Seq_LNCAP_Human2.50905358
6* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.47543966
7* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.47543966
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45637106
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.35566261
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.20953594
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16117333
12* SOX2_20726797_ChIP-Seq_SW620_Human2.14699245
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08928644
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.06495748
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.06495748
16GATA1_22025678_ChIP-Seq_K562_Human2.05426583
17CLOCK_20551151_ChIP-Seq_293T_Human2.00631536
18* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98880760
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94602137
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93316813
21TP53_18474530_ChIP-ChIP_U2OS_Human1.91943635
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.91424181
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.88874718
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86964508
25* LXR_22158963_ChIP-Seq_LIVER_Mouse1.82483477
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.79842831
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74152565
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67604575
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.62724874
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.61873375
31* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61701372
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61562891
33AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56176449
34FOXA1_25552417_ChIP-Seq_VCAP_Human1.55367765
35ZNF263_19887448_ChIP-Seq_K562_Human1.55252319
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53706507
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51594809
38ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50322907
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49217852
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.48797909
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.45589895
42EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45394210
43* CJUN_26792858_Chip-Seq_BT549_Human1.45171018
44GATA4_25053715_ChIP-Seq_YYC3_Human1.44754257
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44331563
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43528580
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.42479139
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42159101
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38820807
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38179875
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37852706
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37221435
53TP53_16413492_ChIP-PET_HCT116_Human1.36566938
54* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33581976
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32080464
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31379893
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30546153
58* TP63_23658742_ChIP-Seq_EP156T_Human1.26817318
59ATF3_27146783_Chip-Seq_COLON_Human1.26325514
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25720722
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25135940
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24034787
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22852184
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21239666
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.21041782
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20704581
67* EP300_21415370_ChIP-Seq_HL-1_Mouse1.20629676
68* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18694940
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18367932
70GATA1_19941826_ChIP-Seq_K562_Human1.17644486
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17567217
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17207601
73* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16274548
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15368670
75* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15336538
76AHR_22903824_ChIP-Seq_MCF-7_Human1.14126580
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.13316795
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12779138
79* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12054667
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11787372
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.10936428
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10898378
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10490739
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10340430
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.08115540
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.07484828
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07105199
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06582878
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.05822872
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05433610
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05226536
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01967531
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01858034
94PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01541044
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01313004
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00701068
97* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00585825
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.00443438
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.00443438
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99329316
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99275470
102FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99064687
103VDR_22108803_ChIP-Seq_LS180_Human0.96915335
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96894862
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95612912
106* TP53_22127205_ChIP-Seq_IMR90_Human0.94899174
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94519937
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94510661
109SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94334296
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93614292
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93100530
112* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91069994
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90230245
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89336513
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88926983
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88528565
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87058929
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87010857
119TFEB_21752829_ChIP-Seq_HELA_Human0.86780779
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85924984
121* ARNT_22903824_ChIP-Seq_MCF-7_Human0.85469362
122BRD4_25478319_ChIP-Seq_HGPS_Human0.85090615
123RXR_22108803_ChIP-Seq_LS180_Human0.85067692
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84758926
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84422026
126* RACK7_27058665_Chip-Seq_MCF-7_Human0.83874217
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83822870
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83133888
129ERG_20517297_ChIP-Seq_VCAP_Human0.82880348
130* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81819880
131GATA6_25053715_ChIP-Seq_YYC3_Human0.81677951
132* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81426135
133* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81257704
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81013573
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79975567
136VDR_24787735_ChIP-Seq_THP-1_Human0.79737984
137GATA3_26560356_Chip-Seq_TH2_Human0.79343919
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.77662030
139* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76604639
140CDX2_22108803_ChIP-Seq_LS180_Human0.76491865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.21318289
2MP0004043_abnormal_pH_regulation4.33226531
3MP0003705_abnormal_hypodermis_morpholog4.01583610
4MP0003195_calcinosis3.98370013
5MP0009780_abnormal_chondrocyte_physiolo3.80207072
6MP0003283_abnormal_digestive_organ3.71821627
7MP0002693_abnormal_pancreas_physiology3.23904785
8MP0000013_abnormal_adipose_tissue3.03838902
9MP0010352_gastrointestinal_tract_polyps2.98954192
10MP0001944_abnormal_pancreas_morphology2.92647227
11MP0005058_abnormal_lysosome_morphology2.89666435
12MP0003183_abnormal_peptide_metabolism2.78264448
13MP0008438_abnormal_cutaneous_collagen2.76053214
14MP0005623_abnormal_meninges_morphology2.66575671
15MP0010368_abnormal_lymphatic_system2.59595837
16MP0005379_endocrine/exocrine_gland_phen2.51636975
17MP0003279_aneurysm2.47336520
18MP0006054_spinal_hemorrhage2.47295804
19MP0000462_abnormal_digestive_system2.44687625
20MP0010386_abnormal_urinary_bladder2.42815553
21MP0000678_abnormal_parathyroid_gland2.39748745
22MP0003941_abnormal_skin_development2.37855876
23MP0002909_abnormal_adrenal_gland2.36816413
24MP0005220_abnormal_exocrine_pancreas2.32987751
25MP0003300_gastrointestinal_ulcer2.23907432
26MP0000920_abnormal_myelination2.10309744
27MP0005023_abnormal_wound_healing2.09592080
28MP0003091_abnormal_cell_migration1.91973072
29MP0002896_abnormal_bone_mineralization1.87548581
30MP0009643_abnormal_urine_homeostasis1.73016599
31MP0003172_abnormal_lysosome_physiology1.71896840
32MP0000003_abnormal_adipose_tissue1.70559759
33MP0002078_abnormal_glucose_homeostasis1.67063788
34MP0010030_abnormal_orbit_morphology1.66398110
35MP0001765_abnormal_ion_homeostasis1.62634486
36MP0005408_hypopigmentation1.58362489
37MP0005275_abnormal_skin_tensile1.57143718
38MP0005257_abnormal_intraocular_pressure1.56677614
39MP0000762_abnormal_tongue_morphology1.52347708
40MP0004264_abnormal_extraembryonic_tissu1.50329745
41MP0004272_abnormal_basement_membrane1.47936335
42MP0000767_abnormal_smooth_muscle1.44024271
43MP0002295_abnormal_pulmonary_circulatio1.43907888
44MP0009053_abnormal_anal_canal1.43844952
45MP0003690_abnormal_glial_cell1.39335466
46MP0001879_abnormal_lymphatic_vessel1.39332051
47MP0005409_darkened_coat_color1.36161080
48MP0001542_abnormal_bone_strength1.35168851
49MP0003252_abnormal_bile_duct1.35051373
50MP0001299_abnormal_eye_distance/1.32478003
51MP0005310_abnormal_salivary_gland1.31077867
52MP0000613_abnormal_salivary_gland1.30789033
53MP0001666_abnormal_nutrient_absorption1.28420861
54MP0001661_extended_life_span1.27483826
55MP0000534_abnormal_ureter_morphology1.26288796
56MP0005501_abnormal_skin_physiology1.23999151
57MP0002928_abnormal_bile_duct1.21954883
58MP0000733_abnormal_muscle_development1.21606998
59MP0009384_cardiac_valve_regurgitation1.19144091
60MP0003634_abnormal_glial_cell1.17159100
61MP0004858_abnormal_nervous_system1.16718756
62MP0005197_abnormal_uvea_morphology1.15954204
63MP0002837_dystrophic_cardiac_calcinosis1.15921937
64MP0001986_abnormal_taste_sensitivity1.14632178
65MP0004185_abnormal_adipocyte_glucose1.14519714
66MP0003868_abnormal_feces_composition1.14120672
67MP0009250_abnormal_appendicular_skeleto1.08573990
68MP0001756_abnormal_urination1.08552196
69MP0001849_ear_inflammation1.08552025
70MP0001346_abnormal_lacrimal_gland1.08295133
71MP0000467_abnormal_esophagus_morphology1.07254215
72MP0000751_myopathy1.05572405
73MP0005595_abnormal_vascular_smooth1.04963808
74MP0000537_abnormal_urethra_morphology1.04638530
75MP0004233_abnormal_muscle_weight1.04569016
76MP0003385_abnormal_body_wall1.04427925
77MP0000681_abnormal_thyroid_gland1.03799857
78MP0003329_amyloid_beta_deposits1.02319630
79MP0003453_abnormal_keratinocyte_physiol1.02277471
80MP0003795_abnormal_bone_structure1.01958413
81MP0006072_abnormal_retinal_apoptosis1.01913499
82MP0005636_abnormal_mineral_homeostasis1.01284290
83MP0003045_fibrosis1.00438705
84MP0005171_absent_coat_pigmentation0.99732878
85MP0005375_adipose_tissue_phenotype0.98672255
86MP0000538_abnormal_urinary_bladder0.98359561
87MP0003191_abnormal_cellular_cholesterol0.96827951
88MP0002108_abnormal_muscle_morphology0.96222026
89MP0006138_congestive_heart_failure0.94333973
90MP0002060_abnormal_skin_morphology0.91295913
91MP0010234_abnormal_vibrissa_follicle0.90973355
92MP0002139_abnormal_hepatobiliary_system0.88929476
93MP0003953_abnormal_hormone_level0.88418087
94MP0003755_abnormal_palate_morphology0.87852301
95MP0002118_abnormal_lipid_homeostasis0.87269097
96MP0001216_abnormal_epidermal_layer0.86934715
97MP0010678_abnormal_skin_adnexa0.86639708
98MP0005165_increased_susceptibility_to0.86501722
99MP0002168_other_aberrant_phenotype0.85411135
100MP0010771_integument_phenotype0.84734901
101MP0001958_emphysema0.84553519
102MP0003566_abnormal_cell_adhesion0.83772965
103MP0009840_abnormal_foam_cell0.83490156
104MP0000428_abnormal_craniofacial_morphol0.82071441
105MP0000230_abnormal_systemic_arterial0.81230151
106MP0000163_abnormal_cartilage_morphology0.81206368
107MP0002098_abnormal_vibrissa_morphology0.81165864
108MP0001533_abnormal_skeleton_physiology0.80601388
109MP0002998_abnormal_bone_remodeling0.80348695
110MP0003866_abnormal_defecation0.79023329
111MP0003959_abnormal_lean_body0.78186027
112MP0000432_abnormal_head_morphology0.77452073
113MP0002138_abnormal_hepatobiliary_system0.77367939
114MP0001270_distended_abdomen0.77252570
115MP0005193_abnormal_anterior_eye0.77159635
116MP0004885_abnormal_endolymph0.75974265
117MP0004782_abnormal_surfactant_physiolog0.75834204
118MP0002234_abnormal_pharynx_morphology0.75198625
119MP0005164_abnormal_response_to0.75112175
120MP0005535_abnormal_body_temperature0.74374603
121MP0000749_muscle_degeneration0.74254594
122MP0001915_intracranial_hemorrhage0.73607230
123MP0000639_abnormal_adrenal_gland0.71930712
124MP0005503_abnormal_tendon_morphology0.71859020
125MP0004084_abnormal_cardiac_muscle0.71621111
126MP0003942_abnormal_urinary_system0.71299198
127MP0005248_abnormal_Harderian_gland0.70589214
128MP0005508_abnormal_skeleton_morphology0.69178584
129MP0003724_increased_susceptibility_to0.68765763
130MP0002796_impaired_skin_barrier0.68762667
131MP0001243_abnormal_dermal_layer0.68725784
132MP0001614_abnormal_blood_vessel0.68430285
133MP0005365_abnormal_bile_salt0.67815921
134MP0000579_abnormal_nail_morphology0.67409406
135MP0002933_joint_inflammation0.67176210
136MP0004947_skin_inflammation0.67032285
137MP0000627_abnormal_mammary_gland0.66638043
138MP0003950_abnormal_plasma_membrane0.66327755
139MP0000604_amyloidosis0.65513759
140MP0002128_abnormal_blood_circulation0.65022338
141MP0003935_abnormal_craniofacial_develop0.64712147
142MP0001485_abnormal_pinna_reflex0.63951749
143MP0001348_abnormal_lacrimal_gland0.62721407
144MP0009379_abnormal_foot_pigmentation0.62692824
145MP0002177_abnormal_outer_ear0.62599369
146MP0002697_abnormal_eye_size0.62247333
147MP0000759_abnormal_skeletal_muscle0.62183014
148MP0004134_abnormal_chest_morphology0.61089746
149MP0002090_abnormal_vision0.60546975
150MP0003448_altered_tumor_morphology0.60456443
151MP0000383_abnormal_hair_follicle0.59594342
152MP0005332_abnormal_amino_acid0.59524648
153MP0005646_abnormal_pituitary_gland0.58414224
154MP0002113_abnormal_skeleton_development0.57386925
155MP0003937_abnormal_limbs/digits/tail_de0.57187678
156MP0003828_pulmonary_edema0.56429744
157MP0002115_abnormal_skeleton_extremities0.55751694
158MP0005621_abnormal_cell_physiology0.55491671
159MP0005360_urolithiasis0.55270891
160MP0005390_skeleton_phenotype0.54998078
161MP0002876_abnormal_thyroid_physiology0.54394051
162MP0000647_abnormal_sebaceous_gland0.53892656

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.37541611
2Protrusio acetabuli (HP:0003179)6.18594307
3Hypoglycemic seizures (HP:0002173)5.82316016
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.81117200
5Hypoglycemic coma (HP:0001325)5.63368376
6Symptomatic seizures (HP:0011145)5.62421564
7Aortic dissection (HP:0002647)4.56842268
8Vascular tortuosity (HP:0004948)4.44147734
9Arterial tortuosity (HP:0005116)4.26975854
10Urinary glycosaminoglycan excretion (HP:0003541)4.16739658
11Mucopolysacchariduria (HP:0008155)4.16739658
12Dysostosis multiplex (HP:0000943)4.14703952
13Aortic aneurysm (HP:0004942)4.14536777
14Generalized aminoaciduria (HP:0002909)4.08400437
15Atrophic scars (HP:0001075)4.02181628
16Insulin-resistant diabetes mellitus (HP:0000831)3.86948628
17Large for gestational age (HP:0001520)3.83656293
18Abnormality of polysaccharide metabolism (HP:0011012)3.79156790
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.79156790
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.79156790
21Ankle contracture (HP:0006466)3.76442111
22Abnormality of calcium-phosphate metabolism (HP:0100530)3.72528055
23Hyperglycemia (HP:0003074)3.66129603
24Follicular hyperkeratosis (HP:0007502)3.57987963
25Ketoacidosis (HP:0001993)3.55775790
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.47808055
27Osteolytic defects of the hand bones (HP:0009699)3.47808055
28Abnormality of endocrine pancreas physiology (HP:0012093)3.43158699
29Abnormality of the pancreatic islet cells (HP:0006476)3.43158699
30Pancreatic islet-cell hyperplasia (HP:0004510)3.40500468
31Wormian bones (HP:0002645)3.35410582
32Vertebral compression fractures (HP:0002953)3.31606832
33Vacuolated lymphocytes (HP:0001922)3.31062692
34Hypokalemia (HP:0002900)3.30462698
35Hyperparathyroidism (HP:0000843)3.28517744
36Soft skin (HP:0000977)3.25997577
37Fragile skin (HP:0001030)3.24166042
38Increased circulating renin level (HP:0000848)3.23520098
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20500217
40Spinal rigidity (HP:0003306)3.19107502
41Bladder diverticulum (HP:0000015)3.14146327
42Hypokalemic alkalosis (HP:0001949)3.05566024
43Neurofibrillary tangles (HP:0002185)3.05560420
44Shallow orbits (HP:0000586)3.02146697
45Late onset (HP:0003584)3.00677144
46Abnormality of the intrinsic pathway (HP:0010989)2.99708305
47Abnormal pancreas size (HP:0012094)2.99656195
48Short nail (HP:0001799)2.97943841
49Abnormality of renin-angiotensin system (HP:0000847)2.90939979
50Abnormality of dentin (HP:0010299)2.89105353
51Neonatal short-limb short stature (HP:0008921)2.88935435
52Cardiovascular calcification (HP:0011915)2.84275992
53Thoracolumbar scoliosis (HP:0002944)2.80193073
54Decreased circulating renin level (HP:0003351)2.73252974
55Broad metatarsal (HP:0001783)2.72973544
56Conjugated hyperbilirubinemia (HP:0002908)2.72444918
57Mitral stenosis (HP:0001718)2.72366082
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.56873753
59Blue sclerae (HP:0000592)2.56845236
60Dilatation of the ascending aorta (HP:0005111)2.53414777
61Premature rupture of membranes (HP:0001788)2.52379197
62Hyperactive renin-angiotensin system (HP:0000841)2.52216780
63Hypomagnesemia (HP:0002917)2.50860176
64Mitral valve prolapse (HP:0001634)2.50253300
65Increased cerebral lipofuscin (HP:0011813)2.50245117
66Abnormality of potassium homeostasis (HP:0011042)2.47955706
67Metabolic alkalosis (HP:0200114)2.47498866
68Protuberant abdomen (HP:0001538)2.46073596
69Abnormality of chloride homeostasis (HP:0011422)2.45408402
70Abdominal distention (HP:0003270)2.44248481
71Elbow flexion contracture (HP:0002987)2.42116593
72Mildly elevated creatine phosphokinase (HP:0008180)2.42034265
73Insulin resistance (HP:0000855)2.41172114
74Type 1 muscle fiber predominance (HP:0003803)2.40431177
75Genu recurvatum (HP:0002816)2.39198923
76Exocrine pancreatic insufficiency (HP:0001738)2.37046789
77Progressive neurologic deterioration (HP:0002344)2.35961654
78Cerebral aneurysm (HP:0004944)2.34656222
79Glycosuria (HP:0003076)2.34176335
80Abnormality of urine glucose concentration (HP:0011016)2.34176335
81Abnormality of liposaccharide metabolism (HP:0010968)2.33161128
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.33161128
83Abnormality of glycolipid metabolism (HP:0010969)2.33161128
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31821767
85Abnormal protein glycosylation (HP:0012346)2.31057557
86Abnormal glycosylation (HP:0012345)2.31057557
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31057557
88Abnormal protein N-linked glycosylation (HP:0012347)2.31057557
89Hyperextensible skin (HP:0000974)2.30167467
90Thin bony cortex (HP:0002753)2.29870420
91Natal tooth (HP:0000695)2.27668277
92Hyperphosphaturia (HP:0003109)2.27496226
93Abnormality of magnesium homeostasis (HP:0004921)2.26658714
94Overgrowth (HP:0001548)2.26192493
95Hypophosphatemia (HP:0002148)2.25719090
96Ulnar bowing (HP:0003031)2.25409220
97Abnormality of the acetabulum (HP:0003170)2.23426517
98Mitral regurgitation (HP:0001653)2.23157209
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20843877
100Right ventricular cardiomyopathy (HP:0011663)2.20619145
101Coronal craniosynostosis (HP:0004440)2.20538771
102Hyperphosphatemia (HP:0002905)2.19355954
103Aortic regurgitation (HP:0001659)2.18970416
104Reduced subcutaneous adipose tissue (HP:0003758)2.18308076
105Elevated alkaline phosphatase (HP:0003155)2.17095828
106Joint laxity (HP:0001388)2.16290946
107Retinal atrophy (HP:0001105)2.13686096
108Abnormality of the common coagulation pathway (HP:0010990)2.13421298
109Vascular calcification (HP:0004934)2.12923490
110Cerebral inclusion bodies (HP:0100314)2.11412654
111Osteomalacia (HP:0002749)2.07553018
112Abnormal urine phosphate concentration (HP:0012599)2.07088672
113Abnormality of proline metabolism (HP:0010907)2.06958156
114Hydroxyprolinuria (HP:0003080)2.06958156
115Aneurysm (HP:0002617)2.06829864
116Abnormality of the distal phalanges of the toes (HP:0010182)2.05405795
117Wrist flexion contracture (HP:0001239)2.03022561
118Tetraparesis (HP:0002273)2.02497653
119Abnormality of alkaline phosphatase activity (HP:0004379)2.01913366
120Agitation (HP:0000713)2.01086736
121Alopecia of scalp (HP:0002293)2.00058083
122Ketosis (HP:0001946)1.98964321
123Delayed epiphyseal ossification (HP:0002663)1.98329832
124Abnormal enzyme/coenzyme activity (HP:0012379)1.96733190
125Spinal cord lesions (HP:0100561)1.96484715
126Syringomyelia (HP:0003396)1.96484715
127Spinal cord compression (HP:0002176)1.96230436
128Tetany (HP:0001281)1.96020712
129Abnormal delivery (HP:0001787)1.95870316
130Cervical subluxation (HP:0003308)1.95306967
131Congenital glaucoma (HP:0001087)1.94829815
132Spondylolisthesis (HP:0003302)1.93250096
133Aortic valve stenosis (HP:0001650)1.92244934
134Abnormality of carpal bone ossification (HP:0006257)1.92127920
135Disproportionate short-trunk short stature (HP:0003521)1.91994902
136Pheochromocytoma (HP:0002666)1.91968265
137Absent frontal sinuses (HP:0002688)1.91597241
138Increased variability in muscle fiber diameter (HP:0003557)1.91006706
139Pterygium (HP:0001059)1.89815467
140Knee flexion contracture (HP:0006380)1.89211045
141Increased connective tissue (HP:0009025)1.88280203
142Abnormality of purine metabolism (HP:0004352)1.87776514
143Hypoplasia of the iris (HP:0007676)1.86758241
144Bowel diverticulosis (HP:0005222)1.83601130
145Polydipsia (HP:0001959)1.83346449
146Abnormal drinking behavior (HP:0030082)1.83346449
147Congenital sensorineural hearing impairment (HP:0008527)1.82713688
148Slender build (HP:0001533)1.80161391
149Abnormal ossification of hand bones (HP:0005921)1.78866492
150Unilateral renal agenesis (HP:0000122)1.78267845
151Wide anterior fontanel (HP:0000260)1.77960154
152Intrahepatic cholestasis (HP:0001406)1.77428424
153Metaphyseal irregularity (HP:0003025)1.76914036
154Polyuria (HP:0000103)1.75140959
155Broad face (HP:0000283)1.74776832
156Biconcave vertebral bodies (HP:0004586)1.74465370
157Tibial bowing (HP:0002982)1.74207949
158Upper limb amyotrophy (HP:0009129)1.74004777
159Distal upper limb amyotrophy (HP:0007149)1.74004777
160Irregular vertebral endplates (HP:0003301)1.72047359
161Papilledema (HP:0001085)1.71734937
162Coxa vara (HP:0002812)1.71477714
163Parakeratosis (HP:0001036)1.71422029
164Skin nodule (HP:0200036)1.70393397
165Enlarged epiphyses (HP:0010580)1.70181217
166Striae distensae (HP:0001065)1.69256796
167Delayed cranial suture closure (HP:0000270)1.69135959
168Camptodactyly of toe (HP:0001836)1.68787368
169Alkalosis (HP:0001948)1.68053777
170Breech presentation (HP:0001623)1.67498778
171Gout (HP:0001997)1.67421155
172Hyperaldosteronism (HP:0000859)1.67003678
173Abnormality of small intestinal villus morphology (HP:0011472)1.66805910
174Villous atrophy (HP:0011473)1.66805910
175Abnormal urine output (HP:0012590)1.66769259
176Ectopia lentis (HP:0001083)1.66236459
177Anteriorly placed anus (HP:0001545)1.65086839
178Abnormality of the umbilical cord (HP:0010881)1.64987186
179Thin skin (HP:0000963)1.63175482
180Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62524073
181Abnormality of skeletal muscle fiber size (HP:0012084)1.62376091
182Disproportionate tall stature (HP:0001519)1.61862590
183Generalized amyotrophy (HP:0003700)1.59524666
184Peritonitis (HP:0002586)1.59017660
185Achilles tendon contracture (HP:0001771)1.58266107
186Onycholysis (HP:0001806)1.58246122
187Vertebral arch anomaly (HP:0008438)1.57739985
188Glucose intolerance (HP:0000833)1.57638067
189Round ear (HP:0100830)1.56901926
190Hallux valgus (HP:0001822)1.56748726
191Selective tooth agenesis (HP:0001592)1.56637407
192Deviation of the hallux (HP:0010051)1.56325594
193Protruding ear (HP:0000411)1.54785515
194Femoral bowing (HP:0002980)1.54619910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.80052503
2PASK3.86405446
3WNK43.25677707
4MYLK3.19715215
5TAOK33.15820696
6STK392.97482171
7EPHB12.92465871
8EPHA22.83539235
9MET2.64960818
10MAP3K22.60373376
11LMTK22.59345809
12ERN12.56315863
13FRK2.46608623
14IRAK32.42248590
15NEK92.38828933
16HIPK22.38334954
17MAPK152.38096194
18LATS22.36421138
19PAK42.25606429
20IRAK12.20092884
21EPHB22.19186048
22TTN2.19084830
23OXSR12.12972691
24TGFBR22.00316999
25NTRK11.90096074
26PRKD31.88502799
27MAP3K121.79974013
28RIPK11.78149363
29MST41.73144080
30BCR1.70690065
31PTK21.63484562
32EPHA31.63365817
33PDGFRA1.61372724
34IRAK21.60130839
35PBK1.58406519
36SCYL21.53825002
37IRAK41.50727965
38PTK61.46348538
39MAP3K11.38259980
40MOS1.37415435
41STK38L1.37135791
42STK241.36239818
43EIF2AK31.35560461
44FLT31.34434979
45LIMK11.30398847
46TESK11.28770400
47ERBB31.24212118
48PAK31.24048532
49TRIB31.21315453
50UHMK11.19755742
51WNK11.19709613
52NEK11.16154750
53STK381.09311252
54PRKG21.07886801
55CAMKK21.07128779
56TIE11.03964134
57LATS11.03946763
58ILK1.02813820
59TNIK1.01222508
60MST1R1.00960881
61CDC42BPA0.91744754
62ICK0.91244177
63NEK60.91036453
64SIK10.88905635
65AKT30.88018922
66BRSK20.87113132
67FER0.84683186
68ROCK20.84528468
69WNK30.84030314
70PDK20.83655072
71MAPKAPK50.83511044
72EIF2AK10.83469051
73PDGFRB0.83358070
74MAP2K20.80083859
75MAP3K30.79992984
76CAMK2D0.79192944
77MELK0.78826279
78PRKCH0.76416959
79TGFBR10.75035713
80DYRK1B0.73220934
81CDK80.72887368
82BMPR1B0.71120670
83CSNK1A1L0.70941526
84GSK3A0.70528142
85PRKD10.69705111
86KSR10.68339285
87PIK3CG0.68092149
88MTOR0.66759463
89MAP3K60.66071479
90JAK20.66055929
91ITK0.64697318
92DDR20.63400146
93JAK30.63148292
94TTK0.62358950
95JAK10.60348718
96ERBB40.60044927
97EEF2K0.60041443
98ARAF0.58910036
99DMPK0.58009432
100FGFR20.57764801
101NUAK10.56688814
102RET0.54611384
103NLK0.54404166
104CDK60.54050792
105PRKD20.53170416
106PAK60.52910805
107FGFR10.52456117
108TRIM280.49110231
109ABL20.48869112
110MAPKAPK30.48589829
111PIM20.46785488
112PDPK10.46527083
113CSK0.46269079
114WEE10.45785468
115CAMK2B0.44531643
116MAP2K10.43432307
117CSNK1G10.42958165
118PTK2B0.42627242
119AKT20.41846878
120TRPM70.41414113
121IGF1R0.41211843
122DAPK30.40872399
123CSNK1G30.40633053
124MAP3K80.39879734
125BRSK10.39639404
126PIK3CA0.38847068
127PAK20.37955506
128CAMK2G0.37675942
129BUB10.36973349
130LRRK20.36672148
131STK100.36342337
132PKN10.35060708
133ACVR1B0.34627813
134BMX0.34480218
135CSNK1A10.34313960
136PKN20.33748612
137NME20.33600000
138CDK90.32047400
139FGFR40.31980959
140RPS6KA20.31648136
141KSR20.31150780
142PAK10.30895876
143CSNK1G20.30548732
144PLK20.30060317
145ADRBK10.29469737
146TBK10.29360597
147SGK2230.29255396
148SGK4940.29255396
149ROCK10.28837420
150PRKCQ0.28658753
151STK30.28266903
152* PRKCE0.28061475
153INSR0.27840403
154AURKB0.27521699
155BCKDK0.26590660
156ABL10.25446010
157TEC0.25217195
158FGFR30.25179400
159PRKACG0.21235411

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.22098805
2Protein export_Homo sapiens_hsa030605.64332500
3Sulfur metabolism_Homo sapiens_hsa009204.69309646
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.00946494
5Steroid biosynthesis_Homo sapiens_hsa001002.40818823
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.39519452
7Lysosome_Homo sapiens_hsa041422.15757662
8Vibrio cholerae infection_Homo sapiens_hsa051102.06927487
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02581851
10Fatty acid elongation_Homo sapiens_hsa000621.94445965
11N-Glycan biosynthesis_Homo sapiens_hsa005101.77318114
12Sphingolipid metabolism_Homo sapiens_hsa006001.67594778
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.67556177
14Small cell lung cancer_Homo sapiens_hsa052221.66637100
15Insulin secretion_Homo sapiens_hsa049111.64458107
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62670026
17Other glycan degradation_Homo sapiens_hsa005111.55265536
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55253580
19Hippo signaling pathway_Homo sapiens_hsa043901.54790389
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53571197
21TGF-beta signaling pathway_Homo sapiens_hsa043501.42514611
22Type II diabetes mellitus_Homo sapiens_hsa049301.40314214
23Vitamin B6 metabolism_Homo sapiens_hsa007501.38150389
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36366897
25Histidine metabolism_Homo sapiens_hsa003401.35196506
26Dilated cardiomyopathy_Homo sapiens_hsa054141.33648929
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32360718
28Type I diabetes mellitus_Homo sapiens_hsa049401.32281442
29Butanoate metabolism_Homo sapiens_hsa006501.30398221
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28107841
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25578884
32* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24904771
33Thyroid cancer_Homo sapiens_hsa052161.22005033
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.21004183
35Selenocompound metabolism_Homo sapiens_hsa004501.20390095
36Ether lipid metabolism_Homo sapiens_hsa005651.17997018
37Arginine biosynthesis_Homo sapiens_hsa002201.12099572
38MicroRNAs in cancer_Homo sapiens_hsa052061.09889320
39Tryptophan metabolism_Homo sapiens_hsa003801.08363549
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.05686988
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03683355
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01852828
43Folate biosynthesis_Homo sapiens_hsa007901.00510831
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99098800
45Melanoma_Homo sapiens_hsa052180.98794433
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97957116
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93553479
48Thyroid hormone synthesis_Homo sapiens_hsa049180.93200018
49Chronic myeloid leukemia_Homo sapiens_hsa052200.90372958
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90240423
51Fructose and mannose metabolism_Homo sapiens_hsa000510.89188431
52Pentose phosphate pathway_Homo sapiens_hsa000300.87286685
53p53 signaling pathway_Homo sapiens_hsa041150.87113268
54Cocaine addiction_Homo sapiens_hsa050300.87077646
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86960405
56Phagosome_Homo sapiens_hsa041450.86585757
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85886679
58Hedgehog signaling pathway_Homo sapiens_hsa043400.85427439
59Linoleic acid metabolism_Homo sapiens_hsa005910.85057701
60* Pathways in cancer_Homo sapiens_hsa052000.84111762
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84092824
62Pancreatic secretion_Homo sapiens_hsa049720.81422364
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80672701
64Protein digestion and absorption_Homo sapiens_hsa049740.80042270
65Pancreatic cancer_Homo sapiens_hsa052120.79888245
66PPAR signaling pathway_Homo sapiens_hsa033200.79104116
67Collecting duct acid secretion_Homo sapiens_hsa049660.77359230
68Gap junction_Homo sapiens_hsa045400.76914185
69Basal cell carcinoma_Homo sapiens_hsa052170.75403296
70Melanogenesis_Homo sapiens_hsa049160.74643766
71Fatty acid metabolism_Homo sapiens_hsa012120.73653888
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73454963
73Glioma_Homo sapiens_hsa052140.71833519
74Bile secretion_Homo sapiens_hsa049760.71212276
75Rheumatoid arthritis_Homo sapiens_hsa053230.71163760
76Biosynthesis of amino acids_Homo sapiens_hsa012300.69551577
77Axon guidance_Homo sapiens_hsa043600.69062537
78Mineral absorption_Homo sapiens_hsa049780.68815029
79Insulin resistance_Homo sapiens_hsa049310.68800968
80ABC transporters_Homo sapiens_hsa020100.68695165
81Fat digestion and absorption_Homo sapiens_hsa049750.68112987
82Starch and sucrose metabolism_Homo sapiens_hsa005000.67635389
83Pyruvate metabolism_Homo sapiens_hsa006200.66439111
84Fatty acid degradation_Homo sapiens_hsa000710.65845381
85Complement and coagulation cascades_Homo sapiens_hsa046100.63455109
86Retinol metabolism_Homo sapiens_hsa008300.63140963
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62862624
88ECM-receptor interaction_Homo sapiens_hsa045120.62620211
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.62590772
90Shigellosis_Homo sapiens_hsa051310.61715704
91Caffeine metabolism_Homo sapiens_hsa002320.60264348
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.59920287
93Peroxisome_Homo sapiens_hsa041460.58905792
94Arginine and proline metabolism_Homo sapiens_hsa003300.57453705
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57371217
96Galactose metabolism_Homo sapiens_hsa000520.55904119
97Renin-angiotensin system_Homo sapiens_hsa046140.55688542
98Chemical carcinogenesis_Homo sapiens_hsa052040.55064461
99AMPK signaling pathway_Homo sapiens_hsa041520.53560363
100Carbon metabolism_Homo sapiens_hsa012000.52467928
101Arachidonic acid metabolism_Homo sapiens_hsa005900.51521565
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51412451
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51171582
104Endometrial cancer_Homo sapiens_hsa052130.47653944
105Nitrogen metabolism_Homo sapiens_hsa009100.47542543
106Regulation of autophagy_Homo sapiens_hsa041400.45342222
107Amoebiasis_Homo sapiens_hsa051460.45284481
108Ovarian steroidogenesis_Homo sapiens_hsa049130.44912194
109Focal adhesion_Homo sapiens_hsa045100.44843380
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44746387
111Prion diseases_Homo sapiens_hsa050200.44650709
112Renal cell carcinoma_Homo sapiens_hsa052110.44596614
113Phenylalanine metabolism_Homo sapiens_hsa003600.44466546
114Glutathione metabolism_Homo sapiens_hsa004800.43630707
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42958473
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42594614
117Rap1 signaling pathway_Homo sapiens_hsa040150.41326041
118Wnt signaling pathway_Homo sapiens_hsa043100.41225237
119Endocytosis_Homo sapiens_hsa041440.39687843
120Prostate cancer_Homo sapiens_hsa052150.38113897
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.37269084
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36978039
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35593589
124Pertussis_Homo sapiens_hsa051330.34028985
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33447184
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33393861
127Legionellosis_Homo sapiens_hsa051340.33346295
128Prolactin signaling pathway_Homo sapiens_hsa049170.32849186
129Malaria_Homo sapiens_hsa051440.31654303
130Dorso-ventral axis formation_Homo sapiens_hsa043200.31468512
131Vitamin digestion and absorption_Homo sapiens_hsa049770.30510343
132Bladder cancer_Homo sapiens_hsa052190.30402140
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.29836824
134Tight junction_Homo sapiens_hsa045300.29283009
135Tyrosine metabolism_Homo sapiens_hsa003500.26582020
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.25920807
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.25352676
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23370215
139Circadian rhythm_Homo sapiens_hsa047100.20879317
140Proteoglycans in cancer_Homo sapiens_hsa052050.20683064
141Tuberculosis_Homo sapiens_hsa051520.20294657
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20001948
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19222479
144* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18635363
145Metabolic pathways_Homo sapiens_hsa011000.16471603
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16454621
147Adherens junction_Homo sapiens_hsa045200.16377971
148Antigen processing and presentation_Homo sapiens_hsa046120.13879217
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13322410
150Estrogen signaling pathway_Homo sapiens_hsa049150.12611741

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »