GNG13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.45707639
2cerebellar Purkinje cell layer development (GO:0021680)7.50332058
3fructose metabolic process (GO:0006000)7.04171960
4protein heterotetramerization (GO:0051290)6.80258025
5C4-dicarboxylate transport (GO:0015740)6.58026975
6metanephric tubule development (GO:0072170)6.33628292
7metanephric nephron tubule development (GO:0072234)6.33628292
8collecting duct development (GO:0072044)6.01172356
9protein insertion into membrane (GO:0051205)5.96338041
10positive regulation of synaptic transmission, GABAergic (GO:0032230)5.95366877
11cellular sodium ion homeostasis (GO:0006883)5.94864249
12neurofilament cytoskeleton organization (GO:0060052)5.89164897
13protein localization to cilium (GO:0061512)5.89097344
14metanephric nephron epithelium development (GO:0072243)5.86060796
15* sensory perception of chemical stimulus (GO:0007606)5.74170693
16detection of calcium ion (GO:0005513)5.59626826
17positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.54323804
18G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.39342300
19metanephric epithelium development (GO:0072207)5.37373626
20musculoskeletal movement (GO:0050881)5.35980977
21multicellular organismal movement (GO:0050879)5.35980977
22inositol phosphate-mediated signaling (GO:0048016)5.30261024
23positive regulation of muscle hypertrophy (GO:0014742)5.27846970
24positive regulation of cardiac muscle hypertrophy (GO:0010613)5.27846970
25aggressive behavior (GO:0002118)5.27765532
26retina layer formation (GO:0010842)5.11596311
27synaptic vesicle exocytosis (GO:0016079)4.96128038
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81922599
29neuron cell-cell adhesion (GO:0007158)4.73251665
30relaxation of smooth muscle (GO:0044557)4.72895181
31behavioral response to nicotine (GO:0035095)4.71654026
32positive regulation of synapse maturation (GO:0090129)4.65151253
33regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62926274
34cellular potassium ion homeostasis (GO:0030007)4.57261370
35cerebellar Purkinje cell differentiation (GO:0021702)4.55453038
36positive regulation of dendritic spine morphogenesis (GO:0061003)4.53436060
37adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.42813650
38glutamate secretion (GO:0014047)4.38817076
39behavioral response to cocaine (GO:0048148)4.38797686
40response to pheromone (GO:0019236)4.37178799
41glutamate receptor signaling pathway (GO:0007215)4.24046810
42cerebellar granule cell differentiation (GO:0021707)4.22473371
43positive regulation of glomerulus development (GO:0090193)4.22335140
44gamma-aminobutyric acid signaling pathway (GO:0007214)4.19730931
45retinal cone cell development (GO:0046549)4.15640673
46regulation of synaptic vesicle exocytosis (GO:2000300)4.13074717
47regulation of potassium ion transmembrane transporter activity (GO:1901016)4.08871298
48negative regulation of norepinephrine secretion (GO:0010700)4.00367265
49vocalization behavior (GO:0071625)3.97494645
50long term synaptic depression (GO:0060292)3.97175040
51endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.96614585
52negative regulation of heart rate (GO:0010459)3.95332199
53phosphorelay signal transduction system (GO:0000160)3.94770742
54regulation of cilium movement (GO:0003352)3.93978739
55neuronal action potential propagation (GO:0019227)3.93610892
56mating behavior (GO:0007617)3.93019745
57relaxation of cardiac muscle (GO:0055119)3.85802503
58positive regulation of amino acid transport (GO:0051957)3.84911156
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84222113
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.81861768
61auditory receptor cell stereocilium organization (GO:0060088)3.81717719
62neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.80652629
63negative regulation of fatty acid transport (GO:2000192)3.80587260
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.80383748
65innervation (GO:0060384)3.79777116
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73645766
67nephron tubule development (GO:0072080)3.71606641
68regulation of potassium ion transmembrane transport (GO:1901379)3.68273548
69transmission of nerve impulse (GO:0019226)3.68201308
70response to water (GO:0009415)3.67783560
71regulation of synapse maturation (GO:0090128)3.64075045
72protein localization to synapse (GO:0035418)3.62719343
73relaxation of muscle (GO:0090075)3.60721295
74synaptic vesicle endocytosis (GO:0048488)3.59574582
75ionotropic glutamate receptor signaling pathway (GO:0035235)3.59371654
76regulation of voltage-gated calcium channel activity (GO:1901385)3.58615562
77regulation of synaptic vesicle transport (GO:1902803)3.57632101
78synaptic vesicle maturation (GO:0016188)3.56882441
79G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.53345212
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.52672266
81potassium ion homeostasis (GO:0055075)3.52507119
82detection of light stimulus involved in visual perception (GO:0050908)3.51767075
83detection of light stimulus involved in sensory perception (GO:0050962)3.51767075
84neuron-neuron synaptic transmission (GO:0007270)3.51022636
85neurotransmitter secretion (GO:0007269)3.51007115
86cell differentiation in hindbrain (GO:0021533)3.50267036
87dopamine biosynthetic process (GO:0042416)3.49902021
88positive regulation of potassium ion transmembrane transport (GO:1901381)3.49711216
89intraciliary transport (GO:0042073)3.46757726
90layer formation in cerebral cortex (GO:0021819)3.46653480
91synaptic transmission, glutamatergic (GO:0035249)3.46565889
92axonal fasciculation (GO:0007413)3.44989834
93serotonin metabolic process (GO:0042428)3.44965416
94parturition (GO:0007567)3.44242155
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40250067
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37568496
97potassium ion transmembrane transport (GO:0071805)3.37256280
98cellular potassium ion transport (GO:0071804)3.37256280
99response to ammonium ion (GO:0060359)3.35708290
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35501949
101neuron recognition (GO:0008038)3.34350779
102cGMP metabolic process (GO:0046068)3.34208177
103mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34175999
104axoneme assembly (GO:0035082)3.33666160
105regulation of neurotransmitter secretion (GO:0046928)3.32267956
106acidic amino acid transport (GO:0015800)3.31501151
107regulation of dopamine secretion (GO:0014059)3.28243924
108sodium ion homeostasis (GO:0055078)3.28023519
109renal tubule development (GO:0061326)3.27030053
110regulation of glutamate receptor signaling pathway (GO:1900449)3.26896491
111membrane depolarization during action potential (GO:0086010)3.23573040
112sodium ion export (GO:0071436)3.20902197
113endocrine hormone secretion (GO:0060986)3.20531954
114striatum development (GO:0021756)3.18364068
115energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17243067
116ATP synthesis coupled proton transport (GO:0015986)3.17243067
117long-term synaptic potentiation (GO:0060291)3.16872668
118phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.14659152
119regulation of amine transport (GO:0051952)3.13871458
120regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13485318
121regulation of synapse structural plasticity (GO:0051823)3.13082458
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12285187
123locomotory exploration behavior (GO:0035641)3.09965802
124nitric oxide biosynthetic process (GO:0006809)3.09600869
125regulation of cell communication by electrical coupling (GO:0010649)3.09334312
126activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.08982824
127dopamine receptor signaling pathway (GO:0007212)3.08524222
128potassium ion transport (GO:0006813)3.08453166
129cellular response to ammonium ion (GO:0071242)3.08132078
130adult walking behavior (GO:0007628)3.07559135
131regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05088452
132regulation of neurotransmitter transport (GO:0051588)3.04610462
133negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03122698
134L-glutamate transport (GO:0015813)3.03016124
135regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02326001
136synaptic transmission (GO:0007268)3.02239275
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01927226
138neurotransmitter transport (GO:0006836)3.00322979
139response to cocaine (GO:0042220)3.00204827
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.99931829
141regulation of postsynaptic membrane potential (GO:0060078)2.99723472
142primary amino compound metabolic process (GO:1901160)2.99110682
143filopodium assembly (GO:0046847)2.98834747
144cell communication by electrical coupling (GO:0010644)2.98165390
145positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97007900
146response to histamine (GO:0034776)2.95930753
147neuronal action potential (GO:0019228)2.95656559
148membrane hyperpolarization (GO:0060081)2.94666315
149long-term memory (GO:0007616)2.94649813
150regulation of sodium ion transmembrane transporter activity (GO:2000649)2.93602122
151regulation of vesicle fusion (GO:0031338)2.92416676
152synapse assembly (GO:0007416)2.91563596
153protein polyglutamylation (GO:0018095)2.91462902
154cellular copper ion homeostasis (GO:0006878)2.91035736
155positive regulation of membrane potential (GO:0045838)2.90855522
156regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.89034012
157rhodopsin mediated signaling pathway (GO:0016056)2.87986057
158respiratory electron transport chain (GO:0022904)2.87849198
159neuromuscular process controlling posture (GO:0050884)2.86472387
160electron transport chain (GO:0022900)2.85054663
161cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84460567
162activation of protein kinase A activity (GO:0034199)2.84451762
163prepulse inhibition (GO:0060134)2.84319717
164chemosensory behavior (GO:0007635)2.84076465
165membrane depolarization (GO:0051899)2.82338284
166short-term memory (GO:0007614)10.8588266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.42222737
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.23470554
3GBX2_23144817_ChIP-Seq_PC3_Human3.71633343
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90246886
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82657397
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80174644
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70617488
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69782486
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69782486
10DROSHA_22980978_ChIP-Seq_HELA_Human2.64874126
11REST_21632747_ChIP-Seq_MESCs_Mouse2.54182236
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50250233
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.46123678
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44943603
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44632132
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40978357
17TAF15_26573619_Chip-Seq_HEK293_Human2.40290740
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36381759
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34658170
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30938790
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.21662314
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19775816
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16799628
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.13753870
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11357087
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.09786435
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.03265149
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.91105083
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89183414
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87453589
31VDR_22108803_ChIP-Seq_LS180_Human1.83869623
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82117026
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79088034
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76867203
35TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74271181
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71855326
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67053818
38SMAD4_21799915_ChIP-Seq_A2780_Human1.61014028
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57985588
40P300_19829295_ChIP-Seq_ESCs_Human1.47265590
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47117387
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44341855
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.44086166
44AR_21572438_ChIP-Seq_LNCaP_Human1.43369890
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.41359981
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38742106
47* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38200391
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37879991
49HTT_18923047_ChIP-ChIP_STHdh_Human1.37380600
50RNF2_27304074_Chip-Seq_NSC_Mouse1.35814365
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34808603
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34234130
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33949910
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28336133
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.27453180
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25517724
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23627834
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22591392
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20681974
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17708812
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16709892
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16280156
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16280156
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.15773510
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15578427
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14596047
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.13923951
68* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11580768
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.08160296
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08008531
71ZNF274_21170338_ChIP-Seq_K562_Hela1.07262534
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06774492
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06098419
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05310931
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.04450799
76AR_19668381_ChIP-Seq_PC3_Human1.03163834
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02792263
78TP53_18474530_ChIP-ChIP_U2OS_Human1.01655836
79ER_23166858_ChIP-Seq_MCF-7_Human1.01602388
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.01394960
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00996347
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00127215
83JUN_21703547_ChIP-Seq_K562_Human0.99895136
84RUNX2_22187159_ChIP-Seq_PCA_Human0.99419357
85STAT3_23295773_ChIP-Seq_U87_Human0.98705035
86AR_25329375_ChIP-Seq_VCAP_Human0.98479565
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97748186
88REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97031268
89OCT1_27270436_Chip-Seq_PROSTATE_Human0.96873551
90BCAT_22108803_ChIP-Seq_LS180_Human0.96474450
91KDM2B_26808549_Chip-Seq_K562_Human0.96330465
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96310610
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95874489
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.95553807
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94969191
96FUS_26573619_Chip-Seq_HEK293_Human0.94734209
97EWS_26573619_Chip-Seq_HEK293_Human0.93844247
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92849876
99AHR_22903824_ChIP-Seq_MCF-7_Human0.92624178
100IGF1R_20145208_ChIP-Seq_DFB_Human0.92379257
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91551121
102ZNF263_19887448_ChIP-Seq_K562_Human0.91212223
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91128865
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91067628
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90828462
106TCF4_23295773_ChIP-Seq_U87_Human0.90464979
107SOX2_21211035_ChIP-Seq_LN229_Gbm0.90312362
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.89977200
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.89232311
110* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89185581
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.87955394
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.87864936
113SOX9_26525672_Chip-Seq_HEART_Mouse0.87666839
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87297948
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87172283
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86982836
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86967478
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86871665
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84267244
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84230298
121TCF4_22108803_ChIP-Seq_LS180_Human0.84069229
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82267372
123KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81328560
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81122387
125* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80388070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction8.78903195
2MP0003880_abnormal_central_pattern4.02839225
3MP0004859_abnormal_synaptic_plasticity3.61683003
4MP0003635_abnormal_synaptic_transmissio3.30463105
5MP0009046_muscle_twitch3.23316275
6MP0005394_taste/olfaction_phenotype3.09405016
7MP0005499_abnormal_olfactory_system3.09405016
8MP0008789_abnormal_olfactory_epithelium2.98049277
9MP0002272_abnormal_nervous_system2.77977593
10MP0008875_abnormal_xenobiotic_pharmacok2.55626019
11MP0009745_abnormal_behavioral_response2.54717988
12MP0002064_seizures2.54665269
13MP0002184_abnormal_innervation2.54378961
14MP0002063_abnormal_learning/memory/cond2.49946578
15MP0002734_abnormal_mechanical_nocicepti2.41075342
16MP0001486_abnormal_startle_reflex2.31988173
17MP0005551_abnormal_eye_electrophysiolog2.29562212
18MP0002572_abnormal_emotion/affect_behav2.24260135
19MP0004270_analgesia2.22081666
20MP0001968_abnormal_touch/_nociception2.20597644
21MP0005645_abnormal_hypothalamus_physiol2.14026284
22MP0002067_abnormal_sensory_capabilities2.06496416
23MP0005423_abnormal_somatic_nervous2.00667640
24MP0002557_abnormal_social/conspecific_i1.96472620
25MP0001501_abnormal_sleep_pattern1.92765767
26MP0001188_hyperpigmentation1.92018198
27MP0001440_abnormal_grooming_behavior1.87202204
28MP0008569_lethality_at_weaning1.82419359
29MP0002736_abnormal_nociception_after1.78927490
30MP0001485_abnormal_pinna_reflex1.73639254
31MP0003878_abnormal_ear_physiology1.72476871
32MP0005377_hearing/vestibular/ear_phenot1.72476871
33MP0004742_abnormal_vestibular_system1.69644608
34MP0004036_abnormal_muscle_relaxation1.59661125
35MP0006276_abnormal_autonomic_nervous1.53279310
36MP0002882_abnormal_neuron_morphology1.51817802
37MP0001970_abnormal_pain_threshold1.50999789
38MP0000778_abnormal_nervous_system1.48828109
39MP0003879_abnormal_hair_cell1.44951127
40MP0002822_catalepsy1.41841787
41MP0002752_abnormal_somatic_nervous1.40534046
42MP0002160_abnormal_reproductive_system1.39903110
43MP0002735_abnormal_chemical_nociception1.38202523
44MP0004145_abnormal_muscle_electrophysio1.37860758
45MP0004142_abnormal_muscle_tone1.37650036
46MP0003011_delayed_dark_adaptation1.37498267
47MP0000566_synostosis1.37359073
48MP0010386_abnormal_urinary_bladder1.32670948
49MP0005646_abnormal_pituitary_gland1.30508678
50MP0004924_abnormal_behavior1.30494124
51MP0005386_behavior/neurological_phenoty1.30494124
52MP0004858_abnormal_nervous_system1.29971956
53MP0002229_neurodegeneration1.27193338
54MP0001502_abnormal_circadian_rhythm1.25865962
55MP0000358_abnormal_cell_content/1.21048093
56MP0001529_abnormal_vocalization1.20973492
57MP0004084_abnormal_cardiac_muscle1.20836805
58MP0006072_abnormal_retinal_apoptosis1.17271547
59MP0002066_abnormal_motor_capabilities/c1.17117512
60MP0004811_abnormal_neuron_physiology1.17086650
61MP0002152_abnormal_brain_morphology1.14434951
62MP0002733_abnormal_thermal_nociception1.13371954
63MP0005620_abnormal_muscle_contractility1.11003716
64MP0001963_abnormal_hearing_physiology1.07866837
65MP0004043_abnormal_pH_regulation1.07484741
66MP0003123_paternal_imprinting1.03910979
67MP0003329_amyloid_beta_deposits1.03747792
68MP0001986_abnormal_taste_sensitivity1.03171657
69MP0001905_abnormal_dopamine_level1.00882362
70MP0003122_maternal_imprinting1.00168766
71MP0000920_abnormal_myelination0.99588176
72MP0000955_abnormal_spinal_cord0.98890025
73MP0002090_abnormal_vision0.98295167
74MP0004215_abnormal_myocardial_fiber0.97000459
75MP0002909_abnormal_adrenal_gland0.95806999
76MP0000372_irregular_coat_pigmentation0.95735068
77MP0006035_abnormal_mitochondrial_morpho0.91431148
78MP0000013_abnormal_adipose_tissue0.88541662
79MP0000631_abnormal_neuroendocrine_gland0.88439767
80MP0009379_abnormal_foot_pigmentation0.88259827
81MP0000569_abnormal_digit_pigmentation0.87840715
82MP0004885_abnormal_endolymph0.86509218
83MP0000026_abnormal_inner_ear0.86076246
84MP0002653_abnormal_ependyma_morphology0.83495313
85MP0003631_nervous_system_phenotype0.82976379
86MP0003633_abnormal_nervous_system0.82923738
87MP0005195_abnormal_posterior_eye0.82832881
88MP0008877_abnormal_DNA_methylation0.82671150
89MP0005410_abnormal_fertilization0.82499965
90MP0002837_dystrophic_cardiac_calcinosis0.81719577
91MP0002277_abnormal_respiratory_mucosa0.81713089
92MP0009697_abnormal_copulation0.76466912
93MP0002638_abnormal_pupillary_reflex0.76136164
94MP0005253_abnormal_eye_physiology0.75225499
95MP0008872_abnormal_physiological_respon0.73914723
96MP0005171_absent_coat_pigmentation0.69911221
97MP0000538_abnormal_urinary_bladder0.69871161
98MP0001542_abnormal_bone_strength0.69665679
99MP0005187_abnormal_penis_morphology0.68788709
100MP0003868_abnormal_feces_composition0.66457240
101MP0004147_increased_porphyrin_level0.66410653
102MP0005389_reproductive_system_phenotype0.65719778
103MP0004233_abnormal_muscle_weight0.65311731
104MP0008874_decreased_physiological_sensi0.65155643
105MP0002069_abnormal_eating/drinking_beha0.64882979
106MP0005595_abnormal_vascular_smooth0.62851690
107MP0000003_abnormal_adipose_tissue0.62569381
108MP0003861_abnormal_nervous_system0.61836126
109MP0003634_abnormal_glial_cell0.61720472
110MP0000534_abnormal_ureter_morphology0.59873455
111MP0002233_abnormal_nose_morphology0.58766168
112MP0003632_abnormal_nervous_system0.58485859
113MP0008775_abnormal_heart_ventricle0.56937624
114MP0001299_abnormal_eye_distance/0.56914954
115MP0003787_abnormal_imprinting0.56052020
116MP0004085_abnormal_heartbeat0.55701891
117MP0001765_abnormal_ion_homeostasis0.55405943
118MP0004484_altered_response_of0.53712159
119MP0000749_muscle_degeneration0.53592057
120MP0006292_abnormal_olfactory_placode0.51227478
121MP0003137_abnormal_impulse_conducting0.50064851
122MP0000015_abnormal_ear_pigmentation0.48600239
123MP0005623_abnormal_meninges_morphology0.48409757
124MP0005535_abnormal_body_temperature0.47250547
125MP0000343_altered_response_to0.47218328
126MP0010770_preweaning_lethality0.46446998
127MP0000230_abnormal_systemic_arterial0.45808879
128MP0005174_abnormal_tail_pigmentation0.44965296
129MP0003956_abnormal_body_size0.44039756
130MP0010234_abnormal_vibrissa_follicle0.43607350
131MP0002083_premature_death0.42136007
132MP0002082_postnatal_lethality0.40953387
133MP0010769_abnormal_survival0.39170987

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)6.21756743
2Postural tremor (HP:0002174)5.98770345
3Febrile seizures (HP:0002373)5.91708050
4Focal motor seizures (HP:0011153)5.37599606
5Intention tremor (HP:0002080)5.23216742
6Absence seizures (HP:0002121)5.20086009
7Abnormality of macular pigmentation (HP:0008002)5.18909843
8Impaired vibration sensation in the lower limbs (HP:0002166)4.93317316
9Myokymia (HP:0002411)4.91769642
10Focal seizures (HP:0007359)4.59975762
11Progressive cerebellar ataxia (HP:0002073)4.52745142
12Visual hallucinations (HP:0002367)4.40615404
13Dialeptic seizures (HP:0011146)4.36270039
14Epileptic encephalopathy (HP:0200134)4.29251323
15Retinal dysplasia (HP:0007973)4.23052145
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.12013977
17Gait imbalance (HP:0002141)3.99435749
18Abnormality of saccadic eye movements (HP:0000570)3.96555143
19Abnormal respiratory motile cilium physiology (HP:0012261)3.88278595
20Congenital primary aphakia (HP:0007707)3.84907457
21Abnormality of ocular smooth pursuit (HP:0000617)3.84851790
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.78549767
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.78549767
24Medial flaring of the eyebrow (HP:0010747)3.67331782
25Abnormal ciliary motility (HP:0012262)3.60884151
26Nephrogenic diabetes insipidus (HP:0009806)3.56465742
27Generalized tonic-clonic seizures (HP:0002069)3.50446728
28Limb dystonia (HP:0002451)3.42397680
29Limb ataxia (HP:0002070)3.32788991
30Congenital stationary night blindness (HP:0007642)3.30120542
31Acute necrotizing encephalopathy (HP:0006965)3.26484023
32Rhinitis (HP:0012384)3.18077491
33Abnormal respiratory epithelium morphology (HP:0012253)3.15511536
34Abnormal respiratory motile cilium morphology (HP:0005938)3.15511536
35Abnormality of midbrain morphology (HP:0002418)3.13866754
36Molar tooth sign on MRI (HP:0002419)3.13866754
37Abnormality of the corticospinal tract (HP:0002492)3.08675816
38Vaginal atresia (HP:0000148)3.04997944
39Dysdiadochokinesis (HP:0002075)3.04894535
40Progressive macrocephaly (HP:0004481)3.04081893
41Central scotoma (HP:0000603)3.01751937
42Abnormal mitochondria in muscle tissue (HP:0008316)3.00459641
43Genital tract atresia (HP:0001827)2.98588773
44Action tremor (HP:0002345)2.92592119
45Poor coordination (HP:0002370)2.88909686
46Impaired vibratory sensation (HP:0002495)2.87401775
47Gait ataxia (HP:0002066)2.87278247
48Gaze-evoked nystagmus (HP:0000640)2.83466139
49Truncal ataxia (HP:0002078)2.76730024
50Mitochondrial inheritance (HP:0001427)2.75483040
51Bony spicule pigmentary retinopathy (HP:0007737)2.74355280
52Scanning speech (HP:0002168)2.68580466
53Broad-based gait (HP:0002136)2.65285427
54Bifid tongue (HP:0010297)2.60733810
55Acute encephalopathy (HP:0006846)2.56983169
56Abnormal rod and cone electroretinograms (HP:0008323)2.53782834
57Syncope (HP:0001279)2.53682199
58Autoamputation (HP:0001218)2.49212998
59Aplasia/Hypoplasia of the lens (HP:0008063)2.46698993
60Optic disc pallor (HP:0000543)2.43234584
61Dysmetria (HP:0001310)2.41186354
62Hyperventilation (HP:0002883)2.39192731
63True hermaphroditism (HP:0010459)2.35832448
64Pancreatic fibrosis (HP:0100732)2.33596522
65Anosmia (HP:0000458)2.28562943
66Anxiety (HP:0000739)2.27605950
67Cerebellar atrophy (HP:0001272)2.24703613
68Hypothermia (HP:0002045)2.23359421
69Increased CSF lactate (HP:0002490)2.22915857
70Hemiparesis (HP:0001269)2.21634792
71Hyperlipoproteinemia (HP:0010980)2.20584200
72Dysphonia (HP:0001618)2.20349470
73Depression (HP:0000716)2.18924496
74Increased serum pyruvate (HP:0003542)2.18701134
75Postaxial hand polydactyly (HP:0001162)2.17387951
76Specific learning disability (HP:0001328)2.16131634
77Palpitations (HP:0001962)2.15965748
78Cerebral edema (HP:0002181)2.13870213
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13542282
80Amblyopia (HP:0000646)2.12775304
81Ventricular fibrillation (HP:0001663)2.09911631
82Slow progression (HP:0003677)2.09818133
83Chronic bronchitis (HP:0004469)2.07544530
84Insidious onset (HP:0003587)2.07437189
85Termporal pattern (HP:0011008)2.07437189
86Focal dystonia (HP:0004373)2.05192305
87Retinitis pigmentosa (HP:0000510)2.04239896
88Torticollis (HP:0000473)2.03117013
89Severe visual impairment (HP:0001141)2.02139631
90Decreased central vision (HP:0007663)2.01882266
91Impaired smooth pursuit (HP:0007772)2.00104366
92Absent/shortened dynein arms (HP:0200106)1.99780891
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.99780891
94Athetosis (HP:0002305)1.96684708
95Nephronophthisis (HP:0000090)1.96667392
96Chronic hepatic failure (HP:0100626)1.94640925
97Abnormality of glycolysis (HP:0004366)1.94617911
98Degeneration of anterior horn cells (HP:0002398)1.94180759
99Abnormality of the anterior horn cell (HP:0006802)1.94180759
100Dysarthria (HP:0001260)1.94044101
101Lipid accumulation in hepatocytes (HP:0006561)1.94005202
102Hepatocellular necrosis (HP:0001404)1.93979970
103Abolished electroretinogram (ERG) (HP:0000550)1.92349029
104Diplopia (HP:0000651)1.90033128
105Abnormality of binocular vision (HP:0011514)1.90033128
106Epileptiform EEG discharges (HP:0011182)1.89518508
107Status epilepticus (HP:0002133)1.88977688
108Agitation (HP:0000713)1.88637884
109Renal Fanconi syndrome (HP:0001994)1.87343159
110Abnormal hair whorl (HP:0010721)1.86270434
111Prolonged QT interval (HP:0001657)1.86101177
112Horizontal nystagmus (HP:0000666)1.85536309
113Supranuclear gaze palsy (HP:0000605)1.85281281
114Scotoma (HP:0000575)1.84539672
115Dysmetric saccades (HP:0000641)1.84455122
116EEG with generalized epileptiform discharges (HP:0011198)1.83302022
117Sudden death (HP:0001699)1.80977121
118Pancreatic cysts (HP:0001737)1.79686892
119Genetic anticipation (HP:0003743)1.79227143
120Hemiplegia (HP:0002301)1.77754335
121Occipital encephalocele (HP:0002085)1.75986078
122Craniofacial dystonia (HP:0012179)1.74041905
123Leukodystrophy (HP:0002415)1.73035389
124Esotropia (HP:0000565)1.72053285
125Left ventricular hypertrophy (HP:0001712)1.71617892
126Synostosis involving the elbow (HP:0003938)1.70699705
127Humeroradial synostosis (HP:0003041)1.70699705
128Increased hepatocellular lipid droplets (HP:0006565)1.70430678
129Increased intramyocellular lipid droplets (HP:0012240)1.65652159
130Urinary urgency (HP:0000012)1.57567153
131Morphological abnormality of the pyramidal tract (HP:0002062)1.57089087
132Intellectual disability, mild (HP:0001256)1.51599718
133Heterochromia iridis (HP:0001100)1.50506475
134Choroideremia (HP:0001139)1.49244464
135Epidermoid cyst (HP:0200040)1.48611528
136Incomplete penetrance (HP:0003829)1.48203030
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.47154107
138Exercise intolerance (HP:0003546)1.46329481
139Aplasia involving bones of the extremities (HP:0009825)1.45892442
140Aplasia involving bones of the upper limbs (HP:0009823)1.45892442
141Aplasia of the phalanges of the hand (HP:0009802)1.45892442
142X-linked dominant inheritance (HP:0001423)1.45458369
143Progressive inability to walk (HP:0002505)1.38815021
144Skin nodule (HP:0200036)1.38678854
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.36727913
146Respiratory failure (HP:0002878)1.35246542
147Increased muscle lipid content (HP:0009058)1.29102947
148Distal lower limb amyotrophy (HP:0008944)1.28814372
149Exertional dyspnea (HP:0002875)1.27256436
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.26126129
151Decreased activity of mitochondrial respiratory chain (HP:0008972)1.26126129
152Global brain atrophy (HP:0002283)1.25828700
153Spastic gait (HP:0002064)1.24862438
154Congenital onset (HP:0003577)1.21767607
155Lactic acidosis (HP:0003128)1.21066785
156Hypsarrhythmia (HP:0002521)1.16525980
157Inability to walk (HP:0002540)1.16164114
158Urinary bladder sphincter dysfunction (HP:0002839)1.14711300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF4.97293926
2RIPK13.19067824
3MYLK2.88147837
4TTK2.72186464
5MAP3K42.65826502
6MAP2K72.55583933
7PRPF4B2.53809113
8CASK2.53744369
9DAPK22.47971044
10PHKG12.44576563
11PHKG22.44576563
12MINK12.27707385
13CAMKK22.20500204
14BRAF2.18983763
15EPHA42.13976658
16NTRK32.13923288
17MAP3K122.01586092
18CSNK1G12.01261799
19GRK51.90660433
20PLK21.86528584
21PNCK1.85025329
22PTK61.84446543
23PAK41.76317479
24PRKG21.73691549
25MAP2K41.73270772
26PIM21.72200544
27BMPR21.63739896
28PRKCG1.60614095
29ERBB31.58374108
30TESK11.55923664
31NME11.54787919
32CAMK2B1.52730432
33MAP3K91.50339425
34RIPK41.50133053
35MARK11.49975605
36CAMK2D1.48355257
37DAPK11.47251970
38NTRK21.46748742
39PDK11.38602754
40MAPK151.38225910
41CAMK2G1.35894013
42STK381.35790494
43CDK191.23926173
44PAK31.23388968
45SIK21.20770891
46PAK61.18586591
47TNIK1.14750011
48RAF11.14306557
49DYRK1A1.10628062
50AKT31.08524807
51CAMK2A1.07647743
52LIMK11.07060009
53STK241.06545478
54ITK1.01971594
55CAMKK11.00989176
56FYN1.00630091
57CDK50.97332171
58STK38L0.96756418
59TAF10.89984910
60TLK10.88375464
61PINK10.86431344
62KSR10.84830436
63CAMK1G0.84066707
64MAPK130.81984542
65SCYL20.81464799
66WNK10.79070266
67CSNK1A10.78431909
68CDK30.76105933
69MAP3K60.75481723
70PRKCE0.74991083
71OXSR10.74117288
72FER0.70097876
73CAMK10.69690774
74SGK2230.68726231
75SGK4940.68726231
76CDK140.67473543
77MAP3K110.66810073
78STK110.66316539
79CDK180.63470638
80ROCK20.62560372
81TSSK60.61970693
82PRKDC0.61703538
83CDK150.60849087
84FGR0.60262756
85NEK10.59423210
86TAOK20.57712341
87DAPK30.56598889
88TRIM280.56401699
89CSNK1D0.56060220
90CSNK1G20.56053313
91MAP3K20.55109093
92PLK30.54764280
93SRC0.54208466
94PTK2B0.53949489
95FES0.53228320
96SGK20.53051666
97RPS6KA30.52995388
98PRKACA0.52476983
99CHEK20.51783556
100CAMK40.51639012
101TNK20.51178662
102PRKG10.50515966
103CDK11A0.50506718
104PTK20.50356271
105PRKCZ0.50021081
106UHMK10.48665193
107BCR0.46820633
108LATS20.46743147
109MOS0.45926850
110CSNK1A1L0.45848960
111EIF2AK10.45808588
112PRKCA0.44729315
113CSNK1E0.44619142
114TYRO30.43471190
115CCNB10.43018549
116RPS6KA20.42658507
117TEC0.42635128
118STK390.42458520
119CSNK1G30.42052574
120PRKCB0.41393777
121HIPK20.40835374
122GRK60.40761347
123MAP3K130.40532539
124KSR20.40074051
125MAPKAPK50.39798387
126RPS6KB10.38889186
127PRKCI0.37377327
128GRK70.35451882
129MAPK100.33263137
130STK160.33220344
131ADRBK10.31332238
132ILK0.30656203
133PRKACG0.30087304
134WNK40.26089089
135MAPK10.25717223
136SGK10.24437313
137MAP4K20.20865277
138MARK20.20850896
139SIK30.18320431
140MAP3K10.16450076
141INSR0.11809480
142MAPK80.10608881
143ROCK10.09750763

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047405.64911844
2Nitrogen metabolism_Homo sapiens_hsa009105.40404002
3Nicotine addiction_Homo sapiens_hsa050333.74020395
4Synaptic vesicle cycle_Homo sapiens_hsa047213.28046033
5* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95469711
6Phototransduction_Homo sapiens_hsa047442.90075735
7* GABAergic synapse_Homo sapiens_hsa047272.74433722
8* Morphine addiction_Homo sapiens_hsa050322.63638665
9* Circadian entrainment_Homo sapiens_hsa047132.60785220
10Oxidative phosphorylation_Homo sapiens_hsa001902.49492273
11* Glutamatergic synapse_Homo sapiens_hsa047242.45782352
12Collecting duct acid secretion_Homo sapiens_hsa049662.44197729
13Long-term potentiation_Homo sapiens_hsa047202.26448032
14* Taste transduction_Homo sapiens_hsa047422.22656348
15Salivary secretion_Homo sapiens_hsa049702.04978416
16Parkinsons disease_Homo sapiens_hsa050122.04384814
17Insulin secretion_Homo sapiens_hsa049112.04063661
18* Dopaminergic synapse_Homo sapiens_hsa047282.01163173
19Pentose phosphate pathway_Homo sapiens_hsa000302.00886821
20Alzheimers disease_Homo sapiens_hsa050101.97421820
21Amphetamine addiction_Homo sapiens_hsa050311.90688829
22Long-term depression_Homo sapiens_hsa047301.82777733
23Fructose and mannose metabolism_Homo sapiens_hsa000511.80650225
24Cardiac muscle contraction_Homo sapiens_hsa042601.78298734
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72626212
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70244205
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68487788
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66405668
29Gastric acid secretion_Homo sapiens_hsa049711.65832563
30* Serotonergic synapse_Homo sapiens_hsa047261.62607336
31* Cholinergic synapse_Homo sapiens_hsa047251.58326602
32Renin secretion_Homo sapiens_hsa049241.56027330
33Huntingtons disease_Homo sapiens_hsa050161.47757193
34Calcium signaling pathway_Homo sapiens_hsa040201.47366466
35Vibrio cholerae infection_Homo sapiens_hsa051101.42626307
36Oxytocin signaling pathway_Homo sapiens_hsa049211.33129933
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26133243
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20581930
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17426803
40GnRH signaling pathway_Homo sapiens_hsa049121.16601566
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16137288
42cAMP signaling pathway_Homo sapiens_hsa040241.14388914
43Gap junction_Homo sapiens_hsa045401.11397061
44Renin-angiotensin system_Homo sapiens_hsa046141.07538092
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05568189
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.91629697
47Estrogen signaling pathway_Homo sapiens_hsa049150.90255289
48Pancreatic secretion_Homo sapiens_hsa049720.87775526
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86005399
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82519075
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82311697
52Melanogenesis_Homo sapiens_hsa049160.80349720
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78364391
54Cocaine addiction_Homo sapiens_hsa050300.76897922
55Thyroid hormone synthesis_Homo sapiens_hsa049180.76379875
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74607236
57Oocyte meiosis_Homo sapiens_hsa041140.71356716
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70106798
59* Alcoholism_Homo sapiens_hsa050340.67645550
60Glycerolipid metabolism_Homo sapiens_hsa005610.67584716
61Carbon metabolism_Homo sapiens_hsa012000.62954464
62Protein export_Homo sapiens_hsa030600.62021714
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58028486
64Biosynthesis of amino acids_Homo sapiens_hsa012300.54276597
65Glioma_Homo sapiens_hsa052140.51750513
66Sphingolipid metabolism_Homo sapiens_hsa006000.50962996
67Axon guidance_Homo sapiens_hsa043600.49591576
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49225377
69Pyruvate metabolism_Homo sapiens_hsa006200.49180435
70Glucagon signaling pathway_Homo sapiens_hsa049220.48535486
71Dilated cardiomyopathy_Homo sapiens_hsa054140.47873384
72Circadian rhythm_Homo sapiens_hsa047100.47573188
73Fatty acid elongation_Homo sapiens_hsa000620.46400107
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46207800
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45834192
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41745813
77Bile secretion_Homo sapiens_hsa049760.39180971
78Ovarian steroidogenesis_Homo sapiens_hsa049130.38763661
79Prion diseases_Homo sapiens_hsa050200.38607668
80Type II diabetes mellitus_Homo sapiens_hsa049300.38125394
81Inositol phosphate metabolism_Homo sapiens_hsa005620.38025758
82Regulation of autophagy_Homo sapiens_hsa041400.36398142
83ErbB signaling pathway_Homo sapiens_hsa040120.34952017
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33349318
85Rheumatoid arthritis_Homo sapiens_hsa053230.33083750
86* Ras signaling pathway_Homo sapiens_hsa040140.32820818
87VEGF signaling pathway_Homo sapiens_hsa043700.31851971
88Mineral absorption_Homo sapiens_hsa049780.31534329
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30941865
90MAPK signaling pathway_Homo sapiens_hsa040100.30242633
91mTOR signaling pathway_Homo sapiens_hsa041500.27591897
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.25752207
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.23524410
94African trypanosomiasis_Homo sapiens_hsa051430.23325745
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22878395
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22201242
97Rap1 signaling pathway_Homo sapiens_hsa040150.22086102
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21662224
99Tight junction_Homo sapiens_hsa045300.21608302
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20610712
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16815864
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16265273
103Choline metabolism in cancer_Homo sapiens_hsa052310.15888536
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15470970
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15453189
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14630288
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14345732
108Non-small cell lung cancer_Homo sapiens_hsa052230.13877180
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.13675103
110Insulin signaling pathway_Homo sapiens_hsa049100.13327878
111Purine metabolism_Homo sapiens_hsa002300.13144993
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.12744560
113Melanoma_Homo sapiens_hsa052180.10919136
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09929129
115Endometrial cancer_Homo sapiens_hsa052130.09567499
116Folate biosynthesis_Homo sapiens_hsa007900.09129136
117Fatty acid biosynthesis_Homo sapiens_hsa000610.08841703
118Phenylalanine metabolism_Homo sapiens_hsa003600.07740755
119Metabolic pathways_Homo sapiens_hsa011000.05618523
120Fatty acid metabolism_Homo sapiens_hsa012120.03993730
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03924093
122Platelet activation_Homo sapiens_hsa046110.01840533
123Endocytosis_Homo sapiens_hsa041440.01808464
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.00252043
125Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0246397
126Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0005592

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