GNG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.94992792
2neuron cell-cell adhesion (GO:0007158)5.92736801
3layer formation in cerebral cortex (GO:0021819)5.85710379
4vocalization behavior (GO:0071625)5.82919174
5nucleobase catabolic process (GO:0046113)5.73131466
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.66315883
7protein localization to synapse (GO:0035418)5.44980504
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43290134
9synaptic vesicle maturation (GO:0016188)5.24284426
10regulation of glutamate receptor signaling pathway (GO:1900449)5.09170825
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02251601
12cell migration in hindbrain (GO:0021535)4.99506070
13locomotory exploration behavior (GO:0035641)4.98539326
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98500799
15synaptic vesicle exocytosis (GO:0016079)4.96104416
16dendritic spine morphogenesis (GO:0060997)4.92066753
17neuron recognition (GO:0008038)4.88586507
18exploration behavior (GO:0035640)4.69364553
19axonal fasciculation (GO:0007413)4.61269364
20central nervous system projection neuron axonogenesis (GO:0021952)4.56407727
21regulation of synapse structural plasticity (GO:0051823)4.54340462
22dendrite morphogenesis (GO:0048813)4.53367878
23regulation of synaptic vesicle exocytosis (GO:2000300)4.46881354
24glutamate secretion (GO:0014047)4.44658715
25negative regulation of microtubule polymerization (GO:0031115)4.41396577
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.38092993
27proline transport (GO:0015824)4.36816477
28positive regulation of synapse maturation (GO:0090129)4.30730300
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.26846759
30postsynaptic membrane organization (GO:0001941)4.26575269
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06960225
32neurotransmitter-gated ion channel clustering (GO:0072578)4.00736344
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.97698513
34neurotransmitter secretion (GO:0007269)3.96674471
35regulation of synaptic vesicle transport (GO:1902803)3.92427413
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90942185
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.85471429
38clathrin coat assembly (GO:0048268)3.83621887
39regulation of neuronal synaptic plasticity (GO:0048168)3.79775568
40glutamate receptor signaling pathway (GO:0007215)3.75028245
41axon extension (GO:0048675)3.74934536
42glycosphingolipid biosynthetic process (GO:0006688)3.69194983
43synaptic transmission, glutamatergic (GO:0035249)3.64600205
44calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.61030670
45activated T cell proliferation (GO:0050798)3.60564863
46central nervous system neuron axonogenesis (GO:0021955)3.58900198
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.55243264
48startle response (GO:0001964)3.55204218
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.49369285
50presynaptic membrane assembly (GO:0097105)3.49340870
51synapse assembly (GO:0007416)3.48120598
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47225605
53positive regulation of mitochondrial fission (GO:0090141)3.45171135
54regulation of dendritic spine morphogenesis (GO:0061001)3.44323413
55positive regulation of synapse assembly (GO:0051965)3.41819527
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41087586
57mitochondrion transport along microtubule (GO:0047497)3.41087586
58neuron-neuron synaptic transmission (GO:0007270)3.39822808
59regulation of synapse maturation (GO:0090128)3.38910350
60gamma-aminobutyric acid transport (GO:0015812)3.38369355
61positive regulation of membrane potential (GO:0045838)3.37517116
62auditory behavior (GO:0031223)3.34119176
63regulation of cAMP-dependent protein kinase activity (GO:2000479)3.33375989
64neurofilament cytoskeleton organization (GO:0060052)3.32632205
65establishment of mitochondrion localization (GO:0051654)3.30970281
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30017731
67neuron projection extension (GO:1990138)3.29824534
68synaptic vesicle endocytosis (GO:0048488)3.28384743
69hippocampus development (GO:0021766)3.25460149
70positive regulation of dendritic spine development (GO:0060999)3.25343990
71cerebellum development (GO:0021549)3.23016421
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22745993
73positive regulation of filopodium assembly (GO:0051491)3.22210415
74presynaptic membrane organization (GO:0097090)3.21654489
75response to auditory stimulus (GO:0010996)3.21294311
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20768857
77regulation of postsynaptic membrane potential (GO:0060078)3.20707515
78organelle transport along microtubule (GO:0072384)3.19466306
79long-term memory (GO:0007616)3.19104675
80positive regulation of axon extension (GO:0045773)3.18549121
81neural tube formation (GO:0001841)3.18307241
82regulation of axon extension (GO:0030516)3.18158427
83innervation (GO:0060384)3.14687215
84sequestering of actin monomers (GO:0042989)3.13946029
85protein localization to cilium (GO:0061512)3.12260201
86epithelial cell differentiation involved in kidney development (GO:0035850)3.11938318
87activation of protein kinase A activity (GO:0034199)3.11837693
88neurotransmitter transport (GO:0006836)3.11303754
89dendrite development (GO:0016358)3.10133542
90cerebral cortex radially oriented cell migration (GO:0021799)3.09606095
91transmission of nerve impulse (GO:0019226)3.08046623
92regulation of feeding behavior (GO:0060259)3.06712884
93regulation of synapse organization (GO:0050807)3.06473893
94intraspecies interaction between organisms (GO:0051703)3.06323303
95social behavior (GO:0035176)3.06323303
96regulation of synapse assembly (GO:0051963)3.04683022
97regulation of synaptic transmission, glutamatergic (GO:0051966)3.04415891
98synapse organization (GO:0050808)3.04212159
99regulation of dendritic spine development (GO:0060998)3.04103299
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03730526
101regulation of respiratory system process (GO:0044065)3.03132136
102axon cargo transport (GO:0008088)2.99146216
103regulation of neurotransmitter secretion (GO:0046928)2.98246826
104neuronal action potential propagation (GO:0019227)2.98043419
105positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.97251334
106mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.97251334
107nerve growth factor signaling pathway (GO:0038180)2.97119234
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96709470
109dendritic spine organization (GO:0097061)2.94115988
110establishment of nucleus localization (GO:0040023)2.93906735
111cerebellar granule cell differentiation (GO:0021707)2.93675442
112positive regulation of amino acid transport (GO:0051957)2.93536223
113regulation of synaptic plasticity (GO:0048167)2.92954343
114learning (GO:0007612)2.92444593
115neuron migration (GO:0001764)2.92115702
116regulation of microtubule polymerization (GO:0031113)2.91591595
117regulation of vesicle fusion (GO:0031338)2.91561968
118regulation of extent of cell growth (GO:0061387)2.90366110
119behavioral defense response (GO:0002209)2.89722217
120heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.89137322
121mechanosensory behavior (GO:0007638)2.82647541
122behavioral response to nicotine (GO:0035095)2.82330290
123retinal ganglion cell axon guidance (GO:0031290)2.81455459
124neuronal ion channel clustering (GO:0045161)2.79901332
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74036386
126sialylation (GO:0097503)2.73483800
127axonogenesis (GO:0007409)2.72644396
128neuromuscular synaptic transmission (GO:0007274)2.72237366
129adult walking behavior (GO:0007628)2.71932404
130regulation of synaptic transmission, GABAergic (GO:0032228)2.69810704
131vesicle transport along microtubule (GO:0047496)2.69370496
132regulation of protein kinase A signaling (GO:0010738)2.67482351
133regulation of neurotransmitter levels (GO:0001505)2.66833157
134establishment of vesicle localization (GO:0051650)2.66078455
135cerebellar Purkinje cell differentiation (GO:0021702)2.65569865
136response to dietary excess (GO:0002021)2.64837573
137positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.63879582
138nervous system development (GO:0007399)2.60293089
139head development (GO:0060322)2.59787543
140forebrain neuron differentiation (GO:0021879)2.59396534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.85951660
2GBX2_23144817_ChIP-Seq_PC3_Human3.59099515
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18102613
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08789274
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90329334
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.84844773
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83466120
8REST_21632747_ChIP-Seq_MESCs_Mouse2.82359517
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64694646
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64694646
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58772812
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56566122
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55668254
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48088277
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42234578
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40350293
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36114401
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.33975117
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30748147
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30208095
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25305733
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.25192749
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.22421852
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18495630
25DROSHA_22980978_ChIP-Seq_HELA_Human2.16231139
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.08347745
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06522328
28AR_21572438_ChIP-Seq_LNCaP_Human2.02776384
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97150189
30ZNF274_21170338_ChIP-Seq_K562_Hela1.95776731
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92859741
32TAF15_26573619_Chip-Seq_HEK293_Human1.86208427
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82088888
34IGF1R_20145208_ChIP-Seq_DFB_Human1.81739352
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.74647580
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72626485
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70241720
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69369240
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68778544
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59926945
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58452627
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55390791
43SMAD4_21799915_ChIP-Seq_A2780_Human1.52166537
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50593095
45* P300_19829295_ChIP-Seq_ESCs_Human1.49221721
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49114579
47RNF2_27304074_Chip-Seq_NSC_Mouse1.48290572
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.47331994
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45036313
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37977035
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37616592
52VDR_22108803_ChIP-Seq_LS180_Human1.36215550
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36000451
54EWS_26573619_Chip-Seq_HEK293_Human1.35181033
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.35111846
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.34057781
57* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33965220
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33843015
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32144218
60CBP_20019798_ChIP-Seq_JUKART_Human1.31920856
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31920856
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31646202
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29456958
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.29163058
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.26655590
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25928119
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24634581
68* AR_25329375_ChIP-Seq_VCAP_Human1.23650003
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22509995
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21327208
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.20749092
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20278257
73AR_19668381_ChIP-Seq_PC3_Human1.18133934
74* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18069384
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.17482390
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16394976
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16297165
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15876066
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15831437
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15831437
81* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15161874
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13710021
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.13223934
84FUS_26573619_Chip-Seq_HEK293_Human1.13163302
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.12924286
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10837851
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10253988
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09902597
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08492792
90STAT3_23295773_ChIP-Seq_U87_Human1.07256996
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06651807
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.06579791
93AHR_22903824_ChIP-Seq_MCF-7_Human1.06496591
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05104472
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.04251179
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.03439876
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01889706
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.01769272
99* KDM2B_26808549_Chip-Seq_REH_Human1.01596623
100JUN_21703547_ChIP-Seq_K562_Human1.01586764
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01458506
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00650693
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.00519193
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00405689
105RUNX2_22187159_ChIP-Seq_PCA_Human1.00150461
106P53_22387025_ChIP-Seq_ESCs_Mouse1.00118964
107* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99782043
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99588518
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99313158
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98893394
111KDM2B_26808549_Chip-Seq_K562_Human0.98864250
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.97543301
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97407885
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96940529
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96456587
116TCF4_23295773_ChIP-Seq_U87_Human0.95889254
117ER_23166858_ChIP-Seq_MCF-7_Human0.95500156
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95453357
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94929792
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93464102
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92793416
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92750869
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91581078
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90257672
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87458098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.93877388
2MP0003880_abnormal_central_pattern4.28100751
3MP0003635_abnormal_synaptic_transmissio3.88851170
4MP0004270_analgesia3.86920613
5MP0005423_abnormal_somatic_nervous3.42026311
6MP0002063_abnormal_learning/memory/cond3.31543830
7MP0001968_abnormal_touch/_nociception3.18743471
8MP0000778_abnormal_nervous_system2.98616527
9MP0002735_abnormal_chemical_nociception2.94068210
10MP0002734_abnormal_mechanical_nocicepti2.90424318
11MP0009745_abnormal_behavioral_response2.88644857
12MP0006276_abnormal_autonomic_nervous2.75948546
13MP0002064_seizures2.66715321
14MP0002572_abnormal_emotion/affect_behav2.62924763
15MP0002733_abnormal_thermal_nociception2.55133384
16MP0002184_abnormal_innervation2.43826792
17MP0002736_abnormal_nociception_after2.41082330
18MP0000569_abnormal_digit_pigmentation2.31247681
19MP0009046_muscle_twitch2.31125954
20MP0001486_abnormal_startle_reflex2.15218623
21MP0001440_abnormal_grooming_behavior2.15062893
22MP0001970_abnormal_pain_threshold2.14517249
23MP0004811_abnormal_neuron_physiology2.12457878
24MP0004858_abnormal_nervous_system2.07162341
25MP0002557_abnormal_social/conspecific_i2.01468175
26MP0002067_abnormal_sensory_capabilities1.92549476
27MP0002272_abnormal_nervous_system1.90916462
28MP0000955_abnormal_spinal_cord1.85723547
29MP0005386_behavior/neurological_phenoty1.81051531
30MP0004924_abnormal_behavior1.81051531
31MP0009780_abnormal_chondrocyte_physiolo1.71077918
32MP0003122_maternal_imprinting1.69197492
33MP0001986_abnormal_taste_sensitivity1.67667567
34MP0001501_abnormal_sleep_pattern1.65516438
35MP0003787_abnormal_imprinting1.63969900
36MP0005645_abnormal_hypothalamus_physiol1.61663399
37MP0002882_abnormal_neuron_morphology1.60533242
38MP0003329_amyloid_beta_deposits1.60335256
39MP0002822_catalepsy1.55973957
40MP0008569_lethality_at_weaning1.45826395
41MP0002909_abnormal_adrenal_gland1.45558566
42MP0002152_abnormal_brain_morphology1.40708323
43MP0002066_abnormal_motor_capabilities/c1.38464430
44MP0001984_abnormal_olfaction1.36754106
45MP0003221_abnormal_cardiomyocyte_apopto1.34697744
46MP0001529_abnormal_vocalization1.33694001
47MP0004885_abnormal_endolymph1.30814929
48MP0008877_abnormal_DNA_methylation1.25340588
49MP0001188_hyperpigmentation1.22270315
50MP0001905_abnormal_dopamine_level1.21188470
51MP0002653_abnormal_ependyma_morphology1.20712453
52MP0000631_abnormal_neuroendocrine_gland1.18505207
53MP0002102_abnormal_ear_morphology1.14542547
54MP0005253_abnormal_eye_physiology1.13846291
55MP0005187_abnormal_penis_morphology1.13597676
56MP0002638_abnormal_pupillary_reflex1.11926107
57MP0003861_abnormal_nervous_system1.11926014
58MP0005646_abnormal_pituitary_gland1.11327257
59MP0002751_abnormal_autonomic_nervous1.06912505
60MP0005394_taste/olfaction_phenotype1.06007004
61MP0005499_abnormal_olfactory_system1.06007004
62MP0001502_abnormal_circadian_rhythm1.03189234
63MP0003879_abnormal_hair_cell1.02044718
64MP0008995_early_reproductive_senescence1.01681349
65MP0004742_abnormal_vestibular_system0.99387854
66MP0002752_abnormal_somatic_nervous0.96212094
67MP0004142_abnormal_muscle_tone0.96047692
68MP0003633_abnormal_nervous_system0.95084606
69MP0001348_abnormal_lacrimal_gland0.91735576
70MP0003121_genomic_imprinting0.91723494
71MP0002069_abnormal_eating/drinking_beha0.91251310
72MP0010386_abnormal_urinary_bladder0.90537657
73MP0003631_nervous_system_phenotype0.90033621
74MP0003634_abnormal_glial_cell0.89269181
75MP0005248_abnormal_Harderian_gland0.88365112
76MP0005551_abnormal_eye_electrophysiolog0.88353379
77MP0006072_abnormal_retinal_apoptosis0.87289203
78MP0003690_abnormal_glial_cell0.86925669
79MP0000751_myopathy0.86289886
80MP0003724_increased_susceptibility_to0.83467420
81MP0008789_abnormal_olfactory_epithelium0.82203986
82MP0004133_heterotaxia0.80805183
83MP0000537_abnormal_urethra_morphology0.80341033
84MP0000049_abnormal_middle_ear0.78189789
85MP0003938_abnormal_ear_development0.77839000
86MP0008961_abnormal_basal_metabolism0.76004234
87MP0004085_abnormal_heartbeat0.75529840
88MP0003137_abnormal_impulse_conducting0.74742695
89MP0001963_abnormal_hearing_physiology0.73396588
90MP0002928_abnormal_bile_duct0.71869520
91MP0003632_abnormal_nervous_system0.71072705
92MP0000604_amyloidosis0.70384990
93MP0003119_abnormal_digestive_system0.70175230
94MP0002229_neurodegeneration0.69486593
95MP0001299_abnormal_eye_distance/0.69212557
96MP0002234_abnormal_pharynx_morphology0.69069507
97MP0009379_abnormal_foot_pigmentation0.68146291
98MP0000015_abnormal_ear_pigmentation0.67845166
99MP0003011_delayed_dark_adaptation0.67429652
100MP0002081_perinatal_lethality0.65844514
101MP0003303_peritoneal_inflammation0.64470457
102MP0001943_abnormal_respiration0.63731244
103MP0003567_abnormal_fetal_cardiomyocyte0.63548407
104MP0000026_abnormal_inner_ear0.63453600
105MP0005409_darkened_coat_color0.63234279
106MP0010770_preweaning_lethality0.62546242
107MP0002082_postnatal_lethality0.62546242
108MP0003890_abnormal_embryonic-extraembry0.62380215
109MP0010769_abnormal_survival0.62191185
110MP0005195_abnormal_posterior_eye0.60874118
111MP0001177_atelectasis0.60107941
112MP0002277_abnormal_respiratory_mucosa0.59601096
113MP0010768_mortality/aging0.58062955
114MP0006292_abnormal_olfactory_placode0.57872111
115MP0000681_abnormal_thyroid_gland0.57441626
116MP0005535_abnormal_body_temperature0.55155533
117MP0003315_abnormal_perineum_morphology0.52566742
118MP0005084_abnormal_gallbladder_morpholo0.52373440
119MP0003956_abnormal_body_size0.51934216
120MP0003172_abnormal_lysosome_physiology0.50817010

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.17727141
2Focal motor seizures (HP:0011153)5.09237784
3Focal seizures (HP:0007359)4.46851814
4Mutism (HP:0002300)4.35655895
5Visual hallucinations (HP:0002367)4.32809449
6Amyotrophic lateral sclerosis (HP:0007354)4.13580027
7Epileptic encephalopathy (HP:0200134)3.90172136
8Papilledema (HP:0001085)3.88051628
9Supranuclear gaze palsy (HP:0000605)3.86845704
10Limb dystonia (HP:0002451)3.70282739
11Excessive salivation (HP:0003781)3.68854085
12Drooling (HP:0002307)3.68854085
13Broad-based gait (HP:0002136)3.67342632
14Progressive cerebellar ataxia (HP:0002073)3.54908074
15Polyphagia (HP:0002591)3.52020835
16Ankle clonus (HP:0011448)3.40212276
17Inappropriate behavior (HP:0000719)3.29027443
18Hyperventilation (HP:0002883)3.25662682
19Progressive inability to walk (HP:0002505)3.24335410
20Agitation (HP:0000713)3.18657224
21Termporal pattern (HP:0011008)3.17759339
22Insidious onset (HP:0003587)3.17759339
23Poor eye contact (HP:0000817)3.16778161
24Abnormality of the corticospinal tract (HP:0002492)3.13393554
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08915646
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.08915646
27Febrile seizures (HP:0002373)3.07118613
28Amblyopia (HP:0000646)3.01403582
29Atonic seizures (HP:0010819)2.97738169
30Action tremor (HP:0002345)2.92761221
31Absence seizures (HP:0002121)2.91846634
32Retinal dysplasia (HP:0007973)2.91099355
33Aplasia/Hypoplasia of the brainstem (HP:0007362)2.89900685
34Hypoplasia of the brainstem (HP:0002365)2.89900685
35Medial flaring of the eyebrow (HP:0010747)2.87939141
36Congenital primary aphakia (HP:0007707)2.87074310
37Akinesia (HP:0002304)2.87020475
38Lissencephaly (HP:0001339)2.82482013
39Nephrogenic diabetes insipidus (HP:0009806)2.80436166
40Abnormal eating behavior (HP:0100738)2.80422233
41Abnormal social behavior (HP:0012433)2.77398200
42Impaired social interactions (HP:0000735)2.77398200
43Urinary urgency (HP:0000012)2.73644294
44Apathy (HP:0000741)2.73257092
45Generalized tonic-clonic seizures (HP:0002069)2.71255401
46Dialeptic seizures (HP:0011146)2.70557015
47Cerebral inclusion bodies (HP:0100314)2.65809908
48Impaired vibration sensation in the lower limbs (HP:0002166)2.63089150
49Inability to walk (HP:0002540)2.63039548
50Urinary bladder sphincter dysfunction (HP:0002839)2.61965749
51Abnormality of binocular vision (HP:0011514)2.59385318
52Diplopia (HP:0000651)2.59385318
53Truncal ataxia (HP:0002078)2.58331205
54Exotropia (HP:0000577)2.54181041
55Genetic anticipation (HP:0003743)2.54016461
56Neurofibrillary tangles (HP:0002185)2.53460000
57Depression (HP:0000716)2.52935907
58Split foot (HP:0001839)2.50769852
59Abnormality of the lower motor neuron (HP:0002366)2.49350313
60Diminished motivation (HP:0000745)2.48593551
61Peripheral hypomyelination (HP:0007182)2.47451530
62Pachygyria (HP:0001302)2.46951328
63Disinhibition (HP:0000734)2.45091654
64Absent speech (HP:0001344)2.43967087
65Hemiparesis (HP:0001269)2.42881200
66Obstructive sleep apnea (HP:0002870)2.42658773
67Stereotypic behavior (HP:0000733)2.41553822
68Abnormality of salivation (HP:0100755)2.39505321
69Genital tract atresia (HP:0001827)2.38838961
70Spastic gait (HP:0002064)2.37692149
71Fetal akinesia sequence (HP:0001989)2.37302911
72Epileptiform EEG discharges (HP:0011182)2.34383359
73EEG with generalized epileptiform discharges (HP:0011198)2.34289459
74Vaginal atresia (HP:0000148)2.33950401
75Megalencephaly (HP:0001355)2.31302648
76Hypsarrhythmia (HP:0002521)2.31060234
77Aqueductal stenosis (HP:0002410)2.27003144
78Shoulder girdle muscle weakness (HP:0003547)2.22831363
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.22376989
80Poor suck (HP:0002033)2.21770702
81Sacral dimple (HP:0000960)2.20370011
82Anxiety (HP:0000739)2.18053059
83Protruding tongue (HP:0010808)2.17749702
84Morphological abnormality of the pyramidal tract (HP:0002062)2.16769542
85Sleep apnea (HP:0010535)2.14200973
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12873178
87Lower limb muscle weakness (HP:0007340)2.11541802
88Abnormality of the hip-girdle musculature (HP:0001445)2.10783082
89Abnormality of the musculature of the pelvis (HP:0001469)2.10783082
90Failure to thrive in infancy (HP:0001531)2.09399669
91Torticollis (HP:0000473)2.08993891
92Hemiplegia (HP:0002301)2.08031329
93True hermaphroditism (HP:0010459)2.07527264
94Pheochromocytoma (HP:0002666)2.07000911
95Gait imbalance (HP:0002141)2.06313865
96Pancreatic cysts (HP:0001737)2.06046607
97Morphological abnormality of the middle ear (HP:0008609)2.05963596
98Insomnia (HP:0100785)2.04983459
99Sporadic (HP:0003745)2.03089701
100Paraplegia (HP:0010550)2.01924782
101Intellectual disability, severe (HP:0010864)1.98720972
102Macroorchidism (HP:0000053)1.97690502
103Pointed chin (HP:0000307)1.96857452
104Hepatoblastoma (HP:0002884)1.95668098
105Hypoventilation (HP:0002791)1.95296805
106Gaze-evoked nystagmus (HP:0000640)1.95151847
107Abnormality of the labia minora (HP:0012880)1.95089688
108Specific learning disability (HP:0001328)1.94721460
109Hypoplasia of the corpus callosum (HP:0002079)1.94426847
110Focal dystonia (HP:0004373)1.92083510
111Muscular hypotonia of the trunk (HP:0008936)1.91244886
112Hyperthyroidism (HP:0000836)1.90441154
113Tented upper lip vermilion (HP:0010804)1.90367234
114Hypothermia (HP:0002045)1.90091099
115Ulnar claw (HP:0001178)1.89822219
116Thyroid-stimulating hormone excess (HP:0002925)1.89365433
117Narrow forehead (HP:0000341)1.87988159
118Cortical dysplasia (HP:0002539)1.87321239
119Poor coordination (HP:0002370)1.86297386
120Spastic tetraplegia (HP:0002510)1.86042421
121Oligodactyly (hands) (HP:0001180)1.85130566
122Esotropia (HP:0000565)1.84552564
123Intention tremor (HP:0002080)1.82717898
124Neuroendocrine neoplasm (HP:0100634)1.82486331
125Open mouth (HP:0000194)1.81508115
126Decreased testicular size (HP:0008734)1.81277049
127Polymicrogyria (HP:0002126)1.81090116
128Impaired smooth pursuit (HP:0007772)1.80542659
129Type II lissencephaly (HP:0007260)1.79924671
130Neoplasm of the adrenal cortex (HP:0100641)1.79674463
131Dysdiadochokinesis (HP:0002075)1.79283788
132Pancreatic fibrosis (HP:0100732)1.78564972
133Dysmetria (HP:0001310)1.78296803
134Restlessness (HP:0000711)1.77211706
135Nephronophthisis (HP:0000090)1.76629040
136Abnormal hair whorl (HP:0010721)1.73857936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.40984365
2MAP3K93.69799384
3NTRK33.32876618
4MAP3K42.94055844
5MINK12.90253020
6MAP2K72.65814684
7NTRK22.64618963
8TRIM282.55840553
9DYRK22.31250714
10MAPK132.25710214
11SIK22.20031909
12EPHA32.16366142
13MAP3K122.09705961
14CASK2.05902047
15KSR12.05046768
16MAP4K21.98740410
17EPHA41.96057287
18ERBB31.87374240
19PAK61.83007964
20PHKG11.76059277
21PHKG21.76059277
22UHMK11.69631969
23DAPK21.67146629
24MAP2K41.62975277
25PINK11.58121577
26PRPF4B1.50527455
27SIK31.49808767
28LATS21.48504659
29CDK51.44406097
30PNCK1.41395282
31PLK21.36009737
32RPS6KA41.31092754
33TNIK1.30319870
34CSNK1G21.28513867
35DAPK11.26138740
36NTRK11.24801470
37KSR21.21971715
38GRK51.17243473
39CAMKK11.13668495
40DYRK31.13002930
41LIMK11.06497690
42TXK1.03826263
43FRK0.99062774
44CDK180.98907103
45BCR0.98866173
46TYRO30.98494991
47PRKCG0.95589599
48CDK140.95530055
49DYRK1B0.92665709
50DYRK1A0.92309564
51CSNK1G30.89969916
52CDK150.89830612
53RET0.89232798
54CDK190.85656387
55PAK30.84983889
56MAP3K60.84764396
57MARK20.79949206
58EPHB20.79654231
59TAOK30.79252915
60CDK11A0.79000863
61WNK30.78855666
62PRKCZ0.75519861
63RPS6KA20.71160002
64CAMK2A0.69274958
65STK110.68261778
66FES0.67232579
67CSNK1A1L0.66317713
68FGFR20.66212049
69RIPK40.63288146
70PRKD30.62929931
71MAP3K20.61967804
72BRD40.60424433
73ADRBK20.57789423
74TAOK10.57740989
75FGR0.56796450
76PKN10.55908326
77TESK10.55849925
78CSNK1G10.51329073
79CAMK1G0.50532664
80FYN0.50307244
81EPHB10.49199867
82CCNB10.48236595
83SCYL20.48213348
84PRKCE0.48144222
85BMPR1B0.47589473
86TAOK20.46458886
87CAMKK20.45936400
88SGK2230.45761028
89SGK4940.45761028
90MAPK120.45407953
91ALK0.44470021
92TESK20.44083757
93MAP3K50.41967500
94MAPK90.41610163
95YES10.40322684
96SGK10.39421462
97CAMK2B0.39038556
98CAMK10.38917740
99CSNK1D0.37449338
100PRKACA0.36735405
101INSRR0.34485357
102BCKDK0.33191692
103ADRBK10.31781580
104PRKACB0.31357097
105LYN0.30027541
106SGK20.29961920
107RPS6KA30.29306100
108MAPK40.28892858
109EGFR0.28605120
110SYK0.28392979
111MAPK100.28378855
112PRKCH0.28369933
113MAP2K60.28032259
114MAPK80.26992086
115GRK70.25783378
116PRKCB0.25778450
117PRKACG0.25647570
118MAP2K10.25259313
119JAK20.25216443
120RAF10.25163602
121STK380.24749027
122PRKAA10.24135906
123OXSR10.23657159
124ICK0.23374394
125HCK0.23032026
126LMTK20.22965908
127PRKG10.22557258
128ROCK10.21755948
129CAMK40.20992967

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41715177
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04484396
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.99960133
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32379085
5* GABAergic synapse_Homo sapiens_hsa047272.26919015
6Long-term potentiation_Homo sapiens_hsa047202.25825615
7Olfactory transduction_Homo sapiens_hsa047402.22989319
8* Circadian entrainment_Homo sapiens_hsa047132.20636235
9* Glutamatergic synapse_Homo sapiens_hsa047242.17778737
10* Dopaminergic synapse_Homo sapiens_hsa047282.13539952
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05792891
12* Morphine addiction_Homo sapiens_hsa050322.05119225
13Axon guidance_Homo sapiens_hsa043602.05090245
14Amphetamine addiction_Homo sapiens_hsa050311.91255365
15* Cholinergic synapse_Homo sapiens_hsa047251.81803849
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73338426
17Long-term depression_Homo sapiens_hsa047301.66097383
18Taste transduction_Homo sapiens_hsa047421.59703498
19* Serotonergic synapse_Homo sapiens_hsa047261.59578569
20Salivary secretion_Homo sapiens_hsa049701.58464995
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56750119
22Gap junction_Homo sapiens_hsa045401.52497846
23Cocaine addiction_Homo sapiens_hsa050301.52134057
24Oxytocin signaling pathway_Homo sapiens_hsa049211.50635770
25Insulin secretion_Homo sapiens_hsa049111.50096125
26Renin secretion_Homo sapiens_hsa049241.48373515
27GnRH signaling pathway_Homo sapiens_hsa049121.46139174
28Gastric acid secretion_Homo sapiens_hsa049711.45152645
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44883521
30ErbB signaling pathway_Homo sapiens_hsa040121.40838854
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37670104
32Glioma_Homo sapiens_hsa052141.32487008
33Estrogen signaling pathway_Homo sapiens_hsa049151.25575185
34Butanoate metabolism_Homo sapiens_hsa006501.24306460
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23959859
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21328744
37Colorectal cancer_Homo sapiens_hsa052101.20944904
38Endometrial cancer_Homo sapiens_hsa052131.20650613
39Collecting duct acid secretion_Homo sapiens_hsa049661.20497493
40Type II diabetes mellitus_Homo sapiens_hsa049301.16169590
41Calcium signaling pathway_Homo sapiens_hsa040201.15564875
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13098303
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.11861453
44Regulation of autophagy_Homo sapiens_hsa041401.08545998
45Oocyte meiosis_Homo sapiens_hsa041141.08129657
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07547048
47Melanogenesis_Homo sapiens_hsa049161.07068000
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06925183
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03600619
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03141707
51Protein export_Homo sapiens_hsa030601.02063219
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98081507
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96647531
54cAMP signaling pathway_Homo sapiens_hsa040240.96387775
55VEGF signaling pathway_Homo sapiens_hsa043700.93968556
56Renal cell carcinoma_Homo sapiens_hsa052110.92099420
57Vibrio cholerae infection_Homo sapiens_hsa051100.90437319
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89763287
59MAPK signaling pathway_Homo sapiens_hsa040100.85404868
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83937723
61Choline metabolism in cancer_Homo sapiens_hsa052310.83169107
62Circadian rhythm_Homo sapiens_hsa047100.82688741
63Dorso-ventral axis formation_Homo sapiens_hsa043200.80516751
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80361014
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.79464649
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78543337
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.77184588
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76348239
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75570709
70Cardiac muscle contraction_Homo sapiens_hsa042600.75405328
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73617917
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73436562
73Phototransduction_Homo sapiens_hsa047440.72831135
74mTOR signaling pathway_Homo sapiens_hsa041500.70679317
75Wnt signaling pathway_Homo sapiens_hsa043100.70627349
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70074661
77* Ras signaling pathway_Homo sapiens_hsa040140.69613554
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69192895
79Endocytosis_Homo sapiens_hsa041440.67466748
80* Alcoholism_Homo sapiens_hsa050340.66532109
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66348022
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66004932
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65747831
84Rap1 signaling pathway_Homo sapiens_hsa040150.65599404
85Ether lipid metabolism_Homo sapiens_hsa005650.65201520
86Non-small cell lung cancer_Homo sapiens_hsa052230.63848270
87Oxidative phosphorylation_Homo sapiens_hsa001900.63444633
88Viral myocarditis_Homo sapiens_hsa054160.61696042
89Insulin signaling pathway_Homo sapiens_hsa049100.61683307
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61326954
91Shigellosis_Homo sapiens_hsa051310.60717973
92Parkinsons disease_Homo sapiens_hsa050120.60481202
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59905471
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58891048
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.58179552
96Dilated cardiomyopathy_Homo sapiens_hsa054140.56072689
97Prolactin signaling pathway_Homo sapiens_hsa049170.55885012
98Prion diseases_Homo sapiens_hsa050200.53726083
99Phagosome_Homo sapiens_hsa041450.53182847
100Primary immunodeficiency_Homo sapiens_hsa053400.51849291
101T cell receptor signaling pathway_Homo sapiens_hsa046600.51833825
102Steroid biosynthesis_Homo sapiens_hsa001000.51495014
103Type I diabetes mellitus_Homo sapiens_hsa049400.49391155
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49224403
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49079281
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47177978
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46580853
108Pancreatic cancer_Homo sapiens_hsa052120.46442958
109Hedgehog signaling pathway_Homo sapiens_hsa043400.45856478
110AMPK signaling pathway_Homo sapiens_hsa041520.45559377
111Alzheimers disease_Homo sapiens_hsa050100.45130216
112* Chemokine signaling pathway_Homo sapiens_hsa040620.44824051
113Hippo signaling pathway_Homo sapiens_hsa043900.44413240
114Salmonella infection_Homo sapiens_hsa051320.44290862
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43566943
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42969873
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42394799
118Thyroid hormone synthesis_Homo sapiens_hsa049180.40995950
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38403300
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33740914
121Rheumatoid arthritis_Homo sapiens_hsa053230.32583384

Most similar genes based on co-expression Upload to Enrichr

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