GNG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.05023253
2Golgi transport vesicle coating (GO:0048200)7.05023253
3pyrimidine nucleobase catabolic process (GO:0006208)6.15952452
4behavioral response to nicotine (GO:0035095)5.80031669
5nucleobase catabolic process (GO:0046113)5.16360064
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08524496
7synaptic vesicle maturation (GO:0016188)4.91272396
8regulation of synaptic vesicle exocytosis (GO:2000300)4.63661041
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.63302123
10protein maturation by protein folding (GO:0022417)4.56841553
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56142505
12insulin secretion (GO:0030073)4.46896268
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.45931601
14endocrine pancreas development (GO:0031018)4.45197252
15peptide hormone processing (GO:0016486)4.38977398
16synaptic vesicle exocytosis (GO:0016079)4.29097805
17detection of calcium ion (GO:0005513)4.28436935
18presynaptic membrane organization (GO:0097090)4.08957968
19regulation of synaptic vesicle transport (GO:1902803)3.95639762
20locomotory exploration behavior (GO:0035641)3.94048703
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.89190978
22vesicle coating (GO:0006901)3.88290260
23protein retention in ER lumen (GO:0006621)3.85222688
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79834254
25positive regulation of insulin secretion (GO:0032024)3.79355315
26regulation of insulin secretion (GO:0050796)3.78358990
27transmission of nerve impulse (GO:0019226)3.73331397
28COPII vesicle coating (GO:0048208)3.72009162
29regulation of type B pancreatic cell apoptotic process (GO:2000674)3.67544608
30axonal fasciculation (GO:0007413)3.66160604
31auditory behavior (GO:0031223)3.65935975
32neuron cell-cell adhesion (GO:0007158)3.65770074
33cerebellar Purkinje cell layer development (GO:0021680)3.64650240
34establishment of mitochondrion localization (GO:0051654)3.63656818
35glutamate secretion (GO:0014047)3.59974174
36activation of protein kinase A activity (GO:0034199)3.55171503
37ER overload response (GO:0006983)3.54691763
38neurotransmitter secretion (GO:0007269)3.48727033
39neuron recognition (GO:0008038)3.47455178
40synapse assembly (GO:0007416)3.47404627
41regulation of peptide hormone secretion (GO:0090276)3.46600234
42negative regulation of catecholamine secretion (GO:0033604)3.44319146
43regulation of peptide secretion (GO:0002791)3.42264158
44peptide hormone secretion (GO:0030072)3.40280465
45signal peptide processing (GO:0006465)3.38043412
46regulation of calcium ion-dependent exocytosis (GO:0017158)3.35537148
47glandular epithelial cell differentiation (GO:0002067)3.29407286
48peptide secretion (GO:0002790)3.29401834
49vocalization behavior (GO:0071625)3.29083732
50type B pancreatic cell development (GO:0003323)3.28035619
51substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.26816885
52substrate-independent telencephalic tangential migration (GO:0021826)3.26816885
53mechanosensory behavior (GO:0007638)3.25347232
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.22003544
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21689721
56retinal ganglion cell axon guidance (GO:0031290)3.19014977
57nitric oxide mediated signal transduction (GO:0007263)3.17399371
58neurofilament cytoskeleton organization (GO:0060052)3.15446956
59positive regulation of peptide hormone secretion (GO:0090277)3.15255053
60neuronal action potential propagation (GO:0019227)3.11685180
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10943669
62positive regulation of peptide secretion (GO:0002793)3.10497263
63negative regulation of norepinephrine secretion (GO:0010700)3.10356740
64nonmotile primary cilium assembly (GO:0035058)3.08598993
65positive regulation of exocytosis (GO:0045921)3.06736965
66exploration behavior (GO:0035640)3.06195618
67proline transport (GO:0015824)3.06056965
68intra-Golgi vesicle-mediated transport (GO:0006891)3.06023345
69regulation of hormone secretion (GO:0046883)3.03640078
70glandular epithelial cell development (GO:0002068)3.03249058
71signal release (GO:0023061)3.01797560
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01626292
73mitochondrion transport along microtubule (GO:0047497)3.01626292
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.01469165
75regulation of vesicle fusion (GO:0031338)3.00375343
76positive regulation of nuclease activity (GO:0032075)3.00208555
77regulation of respiratory system process (GO:0044065)2.99899267
78regulation of glucocorticoid secretion (GO:2000849)2.99057970
79* cellular response to glucagon stimulus (GO:0071377)2.98478597
80regulation of glutamate receptor signaling pathway (GO:1900449)2.97576364
81response to pheromone (GO:0019236)2.97325213
82regulation of exocytosis (GO:0017157)2.95758603
83exocrine pancreas development (GO:0031017)2.95441354
84layer formation in cerebral cortex (GO:0021819)2.94448293
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.93624124
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93064720
87synaptic transmission, cholinergic (GO:0007271)2.92594277
88synaptic transmission, glutamatergic (GO:0035249)2.92035150
89vesicle transport along microtubule (GO:0047496)2.90126194
90protein localization to cilium (GO:0061512)2.90085530
91neurotransmitter-gated ion channel clustering (GO:0072578)2.89557171
92protein targeting to Golgi (GO:0000042)2.89460502
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89069946
94sequestering of metal ion (GO:0051238)2.88518495
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88381438
96chemosensory behavior (GO:0007635)2.87413602
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87092033
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86737217
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85702566
100postsynaptic membrane organization (GO:0001941)2.84687353
101neuromuscular synaptic transmission (GO:0007274)2.84580995
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84579521
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83400870
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82897470
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.82582731
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81949593
107calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81438823
108protein polyglutamylation (GO:0018095)2.80352584
109kidney morphogenesis (GO:0060993)2.80276470
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79465845
111innervation (GO:0060384)2.78317860
112regulation of neuronal synaptic plasticity (GO:0048168)2.77582714
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77111190
114regulation of peptide transport (GO:0090087)2.76475278
115glycerophospholipid catabolic process (GO:0046475)2.76350212
116neurotransmitter transport (GO:0006836)2.76135741
117protein localization to Golgi apparatus (GO:0034067)2.75170544
118protein localization to synapse (GO:0035418)2.74302061
119positive regulation of synapse assembly (GO:0051965)2.73683156
120regulation of neurotransmitter uptake (GO:0051580)2.72969234
121glutamate receptor signaling pathway (GO:0007215)2.72787694
122organelle transport along microtubule (GO:0072384)2.72228635
123adult walking behavior (GO:0007628)2.71751116
124response to auditory stimulus (GO:0010996)2.71488386
125dendritic spine morphogenesis (GO:0060997)2.70845568
126regulation of nuclease activity (GO:0032069)2.69342897
127dendrite morphogenesis (GO:0048813)2.69124614
128inner ear receptor cell development (GO:0060119)2.68345741
129neuronal ion channel clustering (GO:0045161)2.66386189
130hormone secretion (GO:0046879)2.65639111
131neuromuscular process controlling posture (GO:0050884)2.65075805
132spinal cord development (GO:0021510)2.64790344
133positive regulation of membrane potential (GO:0045838)2.64350800
134neuron-neuron synaptic transmission (GO:0007270)2.64054326
135regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.64037068
136synapse organization (GO:0050808)2.63518257
137cell communication by electrical coupling (GO:0010644)2.63413128
138cell migration in hindbrain (GO:0021535)2.63024631
139macroautophagy (GO:0016236)2.62954409
140positive regulation of vesicle fusion (GO:0031340)2.62420314
141toxin metabolic process (GO:0009404)2.61648474
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60972744
143presynaptic membrane assembly (GO:0097105)2.59163140
144negative regulation of insulin secretion (GO:0046676)2.58361936
145regulation of beta-amyloid formation (GO:1902003)2.58131591
146regulation of synapse structural plasticity (GO:0051823)2.58055145
147endoplasmic reticulum unfolded protein response (GO:0030968)2.57732305
148gamma-aminobutyric acid transport (GO:0015812)2.57570799
149negative regulation of telomere maintenance (GO:0032205)2.56953154
150negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56362341
151membrane depolarization during action potential (GO:0086010)2.55223957
152behavioral response to ethanol (GO:0048149)2.54975521
153regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.53515454
154regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.53515454
155regulation of telomere maintenance (GO:0032204)2.52825421
156regulation of microtubule-based movement (GO:0060632)2.51541385
157cellular ketone body metabolic process (GO:0046950)2.51360801
158behavioral response to cocaine (GO:0048148)2.48394728
159startle response (GO:0001964)2.47302839
160regulation of respiratory gaseous exchange (GO:0043576)2.45935935
161water-soluble vitamin biosynthetic process (GO:0042364)2.45907007
162olfactory bulb development (GO:0021772)2.44363298
163adult behavior (GO:0030534)2.44099731
164neuronal action potential (GO:0019228)2.39431738
165regulation of action potential (GO:0098900)2.38386656
166positive regulation of synapse maturation (GO:0090129)2.37580504
167ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36540508
168ganglion development (GO:0061548)2.34857165
169establishment of protein localization to mitochondrial membrane (GO:0090151)2.34373845
170axon cargo transport (GO:0008088)2.33975952
171cell differentiation in spinal cord (GO:0021515)2.33531280
172spinal cord motor neuron differentiation (GO:0021522)2.33033777
173C4-dicarboxylate transport (GO:0015740)2.32291760
174multicellular organismal signaling (GO:0035637)2.31264077
175cell proliferation in forebrain (GO:0021846)2.30244702
176membrane hyperpolarization (GO:0060081)2.29773399
177protein complex biogenesis (GO:0070271)2.29272999
178reflex (GO:0060004)2.29232833
179anterograde axon cargo transport (GO:0008089)2.28697064
180intraciliary transport (GO:0042073)2.28556116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05213647
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50923737
3GBX2_23144817_ChIP-Seq_PC3_Human3.27301033
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.99837168
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61860838
6* REST_18959480_ChIP-ChIP_MESCs_Mouse2.48675634
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47205713
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43041959
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39417910
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31851670
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27384095
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.20493623
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16438749
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15410100
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14991999
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.14955052
17DROSHA_22980978_ChIP-Seq_HELA_Human2.14296784
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12728353
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.12253682
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11402045
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06800741
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00907437
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.98071641
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94068501
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90593344
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90304324
27IGF1R_20145208_ChIP-Seq_DFB_Human1.89803821
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.87941662
29ZNF274_21170338_ChIP-Seq_K562_Hela1.86894058
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84102115
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81605434
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81605434
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.70284083
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68284605
35SMAD4_21799915_ChIP-Seq_A2780_Human1.64043153
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.61582362
37FUS_26573619_Chip-Seq_HEK293_Human1.60984724
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50876734
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50611383
40STAT3_23295773_ChIP-Seq_U87_Human1.50281891
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.48889399
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48501880
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44312604
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42040220
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41139400
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.39895019
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38116457
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38095153
49* EWS_26573619_Chip-Seq_HEK293_Human1.37074528
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35409953
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35409953
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32393087
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32171984
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31963507
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30159773
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29657229
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29415274
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29383920
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24510482
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24494252
61P300_19829295_ChIP-Seq_ESCs_Human1.24183488
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23585288
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22138448
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20861989
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20265317
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20107279
67* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20040268
68AR_25329375_ChIP-Seq_VCAP_Human1.19735293
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19118435
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19001255
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18731005
72AR_19668381_ChIP-Seq_PC3_Human1.18675185
73TAF15_26573619_Chip-Seq_HEK293_Human1.18633963
74IRF1_19129219_ChIP-ChIP_H3396_Human1.18090709
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17824039
76* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.17744245
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17519491
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17207762
79GATA1_22025678_ChIP-Seq_K562_Human1.16618243
80TCF4_23295773_ChIP-Seq_U87_Human1.16275937
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16073534
82CBP_20019798_ChIP-Seq_JUKART_Human1.15827715
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15827715
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14498529
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.14427870
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12538871
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.12116977
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11015240
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.10994587
90AR_21572438_ChIP-Seq_LNCaP_Human1.09786265
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09641709
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09267690
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08933829
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.07003712
95RUNX2_22187159_ChIP-Seq_PCA_Human1.06043687
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05893659
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04857919
98* TP53_22573176_ChIP-Seq_HFKS_Human1.04817518
99ER_23166858_ChIP-Seq_MCF-7_Human1.03973840
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03944536
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03663858
102VDR_22108803_ChIP-Seq_LS180_Human1.03549672
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03284915
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00251398
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99673282
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99344220
107* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96909717
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96767248
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96695715
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.96115930
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95571978
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95375960
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94618150
114RING1B_27294783_Chip-Seq_ESCs_Mouse0.94170151
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.92671361
116BCAT_22108803_ChIP-Seq_LS180_Human0.92369501
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92362803
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91690292
119JUN_21703547_ChIP-Seq_K562_Human0.91037729
120RNF2_27304074_Chip-Seq_NSC_Mouse0.90813728
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89959212
122AHR_22903824_ChIP-Seq_MCF-7_Human0.89897607
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.89362830
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89075445
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88391168
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88324974
127* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88253881
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87981106
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87883298
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86497728
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85281794
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84142295
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83847597
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.81561862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.19218561
2MP0002909_abnormal_adrenal_gland3.78315502
3MP0003283_abnormal_digestive_organ3.47514396
4MP0002877_abnormal_melanocyte_morpholog3.44446182
5MP0004859_abnormal_synaptic_plasticity3.32853136
6MP0004043_abnormal_pH_regulation3.28073357
7MP0000013_abnormal_adipose_tissue3.25105805
8MP0004270_analgesia3.13106502
9MP0010386_abnormal_urinary_bladder2.89538644
10MP0002693_abnormal_pancreas_physiology2.83999847
11MP0002837_dystrophic_cardiac_calcinosis2.72405379
12MP0003635_abnormal_synaptic_transmissio2.64128081
13MP0003183_abnormal_peptide_metabolism2.50771036
14MP0001944_abnormal_pancreas_morphology2.50370938
15MP0005645_abnormal_hypothalamus_physiol2.48118617
16MP0005646_abnormal_pituitary_gland2.38211212
17MP0005379_endocrine/exocrine_gland_phen2.35512883
18MP0008877_abnormal_DNA_methylation2.30729340
19MP0003122_maternal_imprinting2.29684394
20MP0003195_calcinosis2.24136599
21MP0000678_abnormal_parathyroid_gland2.22687271
22MP0002734_abnormal_mechanical_nocicepti2.15910862
23MP0002063_abnormal_learning/memory/cond2.05510369
24MP0003880_abnormal_central_pattern1.90907530
25MP0003123_paternal_imprinting1.87705502
26MP0002572_abnormal_emotion/affect_behav1.87328379
27MP0002102_abnormal_ear_morphology1.87111367
28MP0009745_abnormal_behavioral_response1.87085575
29MP0002733_abnormal_thermal_nociception1.85417052
30MP0006292_abnormal_olfactory_placode1.83974542
31MP0006072_abnormal_retinal_apoptosis1.81199929
32MP0002638_abnormal_pupillary_reflex1.79475384
33MP0002064_seizures1.78508693
34MP0004142_abnormal_muscle_tone1.76621259
35MP0002078_abnormal_glucose_homeostasis1.71683719
36MP0003787_abnormal_imprinting1.62760360
37MP0001970_abnormal_pain_threshold1.59942553
38MP0002272_abnormal_nervous_system1.59730922
39MP0006276_abnormal_autonomic_nervous1.58581097
40MP0005423_abnormal_somatic_nervous1.58075111
41MP0002653_abnormal_ependyma_morphology1.56809488
42MP0005551_abnormal_eye_electrophysiolog1.54414108
43MP0002735_abnormal_chemical_nociception1.51702901
44MP0004133_heterotaxia1.49075577
45MP0000003_abnormal_adipose_tissue1.48075778
46MP0005220_abnormal_exocrine_pancreas1.47354751
47MP0009046_muscle_twitch1.45313671
48MP0001501_abnormal_sleep_pattern1.43802893
49MP0003879_abnormal_hair_cell1.42652209
50MP0008961_abnormal_basal_metabolism1.42371642
51MP0002557_abnormal_social/conspecific_i1.40955657
52MP0005499_abnormal_olfactory_system1.40555887
53MP0005394_taste/olfaction_phenotype1.40555887
54MP0003172_abnormal_lysosome_physiology1.39084450
55MP0001502_abnormal_circadian_rhythm1.38348579
56MP0001485_abnormal_pinna_reflex1.38019834
57MP0002876_abnormal_thyroid_physiology1.36426254
58MP0001968_abnormal_touch/_nociception1.34634967
59MP0002184_abnormal_innervation1.33015352
60MP0004858_abnormal_nervous_system1.30905763
61MP0002822_catalepsy1.29808443
62MP0001986_abnormal_taste_sensitivity1.29323987
63MP0000955_abnormal_spinal_cord1.28374975
64MP0004811_abnormal_neuron_physiology1.28179691
65MP0001905_abnormal_dopamine_level1.28165746
66MP0002234_abnormal_pharynx_morphology1.27770807
67MP0000631_abnormal_neuroendocrine_gland1.25128972
68MP0001486_abnormal_startle_reflex1.23300928
69MP0008789_abnormal_olfactory_epithelium1.23051648
70MP0004742_abnormal_vestibular_system1.22508961
71MP0003890_abnormal_embryonic-extraembry1.19760232
72MP0003329_amyloid_beta_deposits1.19677683
73MP0003011_delayed_dark_adaptation1.19277899
74MP0005535_abnormal_body_temperature1.18348772
75MP0002752_abnormal_somatic_nervous1.18127963
76MP0000462_abnormal_digestive_system1.17566468
77MP0003953_abnormal_hormone_level1.16192704
78MP0004924_abnormal_behavior1.10175936
79MP0005386_behavior/neurological_phenoty1.10175936
80MP0001440_abnormal_grooming_behavior1.09811627
81MP0002067_abnormal_sensory_capabilities1.09544906
82MP0002896_abnormal_bone_mineralization1.09497374
83MP0001984_abnormal_olfaction1.08560360
84MP0002938_white_spotting1.08005067
85MP0002152_abnormal_brain_morphology1.07226960
86MP0008569_lethality_at_weaning1.04774388
87MP0002163_abnormal_gland_morphology1.02120745
88MP0004885_abnormal_endolymph1.00252809
89MP0002069_abnormal_eating/drinking_beha0.97617932
90MP0008872_abnormal_physiological_respon0.96715140
91MP0000049_abnormal_middle_ear0.96504755
92MP0000026_abnormal_inner_ear0.96330654
93MP0001765_abnormal_ion_homeostasis0.95540118
94MP0003861_abnormal_nervous_system0.95218074
95MP0002066_abnormal_motor_capabilities/c0.95087290
96MP0002882_abnormal_neuron_morphology0.93835039
97MP0005187_abnormal_penis_morphology0.93824909
98MP0002928_abnormal_bile_duct0.93103602
99MP0000778_abnormal_nervous_system0.92096638
100MP0001963_abnormal_hearing_physiology0.91974396
101MP0000566_synostosis0.91263354
102MP0005195_abnormal_posterior_eye0.90776222
103MP0000613_abnormal_salivary_gland0.86839943
104MP0003119_abnormal_digestive_system0.86808093
105MP0000569_abnormal_digit_pigmentation0.86664681
106MP0003633_abnormal_nervous_system0.86636499
107MP0001299_abnormal_eye_distance/0.86122122
108MP0005448_abnormal_energy_balance0.85934774
109MP0004264_abnormal_extraembryonic_tissu0.84842719
110MP0003938_abnormal_ear_development0.80015020
111MP0001529_abnormal_vocalization0.77880168
112MP0002229_neurodegeneration0.77809353
113MP0002160_abnormal_reproductive_system0.77111976
114MP0000681_abnormal_thyroid_gland0.76323723
115MP0003634_abnormal_glial_cell0.76131990
116MP0002736_abnormal_nociception_after0.74797756
117MP0000538_abnormal_urinary_bladder0.74306237
118MP0001664_abnormal_digestion0.73708278
119MP0003959_abnormal_lean_body0.73062545
120MP0003878_abnormal_ear_physiology0.73051161
121MP0005377_hearing/vestibular/ear_phenot0.73051161
122MP0003868_abnormal_feces_composition0.71492203
123MP0005310_abnormal_salivary_gland0.71461150
124MP0003937_abnormal_limbs/digits/tail_de0.70598190
125MP0001270_distended_abdomen0.70431054
126MP0000230_abnormal_systemic_arterial0.69794194
127MP0004085_abnormal_heartbeat0.69563404
128MP0001188_hyperpigmentation0.68992662
129MP0003121_genomic_imprinting0.68259434
130MP0002751_abnormal_autonomic_nervous0.67951870
131MP0005253_abnormal_eye_physiology0.67516782
132MP0004145_abnormal_muscle_electrophysio0.66935164

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.52297835
2Hyperinsulinemic hypoglycemia (HP:0000825)5.71332903
3Hypoglycemic seizures (HP:0002173)5.29221243
4Symptomatic seizures (HP:0011145)5.12624727
5Visual hallucinations (HP:0002367)4.86084213
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.42318723
7Agitation (HP:0000713)4.00574096
8Hypoglycemic coma (HP:0001325)3.92510238
9Hyperglycemia (HP:0003074)3.68945356
10Pheochromocytoma (HP:0002666)3.62232198
11Insulin-resistant diabetes mellitus (HP:0000831)3.61456145
12Papilledema (HP:0001085)3.58460737
13Decreased circulating renin level (HP:0003351)3.55769972
14EEG with generalized epileptiform discharges (HP:0011198)3.31408945
15Hypsarrhythmia (HP:0002521)3.27979666
16Ketoacidosis (HP:0001993)3.27719580
17Focal motor seizures (HP:0011153)3.24145843
18Pancreatic fibrosis (HP:0100732)3.23719807
19Epileptiform EEG discharges (HP:0011182)3.22237004
20Pancreatic cysts (HP:0001737)3.17842271
21Neuroendocrine neoplasm (HP:0100634)3.16739704
22Abnormality of endocrine pancreas physiology (HP:0012093)3.14604900
23Abnormality of the pancreatic islet cells (HP:0006476)3.14604900
24Nephronophthisis (HP:0000090)3.04363611
25Polyphagia (HP:0002591)3.03541325
26True hermaphroditism (HP:0010459)3.00348520
27Abnormality of midbrain morphology (HP:0002418)2.92393364
28Molar tooth sign on MRI (HP:0002419)2.92393364
29Epileptic encephalopathy (HP:0200134)2.90983232
30Medial flaring of the eyebrow (HP:0010747)2.87891713
31Lissencephaly (HP:0001339)2.84203540
32Large for gestational age (HP:0001520)2.83066569
33Hyperparathyroidism (HP:0000843)2.82468324
34Pancreatic islet-cell hyperplasia (HP:0004510)2.82182983
35Urinary glycosaminoglycan excretion (HP:0003541)2.79528929
36Mucopolysacchariduria (HP:0008155)2.79528929
37Abnormal pancreas size (HP:0012094)2.73804280
38Hemiparesis (HP:0001269)2.73282402
39Abnormality of the labia minora (HP:0012880)2.73103982
40Atonic seizures (HP:0010819)2.69067098
41Hypokalemia (HP:0002900)2.69030131
42Hypercortisolism (HP:0001578)2.67365030
43Broad-based gait (HP:0002136)2.64039919
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58876897
45Abnormality of polysaccharide metabolism (HP:0011012)2.58876897
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58876897
47Absence seizures (HP:0002121)2.58275159
48Late onset (HP:0003584)2.58244098
49Focal seizures (HP:0007359)2.57409298
50Retinal dysplasia (HP:0007973)2.56363973
51Congenital primary aphakia (HP:0007707)2.55831808
52Menstrual irregularities (HP:0000858)2.55443544
53Supranuclear gaze palsy (HP:0000605)2.51911370
54Osteomalacia (HP:0002749)2.49877373
55Dysostosis multiplex (HP:0000943)2.48778189
56Anxiety (HP:0000739)2.46944397
57Pachygyria (HP:0001302)2.46094965
58Abnormality of the renal medulla (HP:0100957)2.45468002
59Depression (HP:0000716)2.44440322
60Failure to thrive in infancy (HP:0001531)2.43502629
61Limb dystonia (HP:0002451)2.43253072
62Nephrogenic diabetes insipidus (HP:0009806)2.40730167
63Hypothermia (HP:0002045)2.37731627
64Generalized tonic-clonic seizures (HP:0002069)2.36948630
65Congenital stationary night blindness (HP:0007642)2.35949288
66Genital tract atresia (HP:0001827)2.31050267
67Amblyopia (HP:0000646)2.30927536
68Abnormality of renin-angiotensin system (HP:0000847)2.30123534
69Chronic hepatic failure (HP:0100626)2.30069828
70Pendular nystagmus (HP:0012043)2.30069025
71Vaginal atresia (HP:0000148)2.29221364
72Ankle clonus (HP:0011448)2.28967337
73Myokymia (HP:0002411)2.28595217
74Retinal atrophy (HP:0001105)2.23744562
75Macroorchidism (HP:0000053)2.22126215
76Poor suck (HP:0002033)2.21929294
77Dialeptic seizures (HP:0011146)2.20118440
78Sclerocornea (HP:0000647)2.19773650
79Restlessness (HP:0000711)2.19191919
80Cystic liver disease (HP:0006706)2.18996858
81Intestinal atresia (HP:0011100)2.14439763
82Oligodactyly (hands) (HP:0001180)2.13028633
83Specific learning disability (HP:0001328)2.11705986
84Papillary thyroid carcinoma (HP:0002895)2.11562171
85Abnormality of potassium homeostasis (HP:0011042)2.08795769
86Adrenal overactivity (HP:0002717)2.08327130
87Dysautonomia (HP:0002459)2.06634714
88Cortical visual impairment (HP:0100704)2.06437344
89Hyperactive renin-angiotensin system (HP:0000841)2.06103092
90Acute necrotizing encephalopathy (HP:0006965)2.05560060
91Spastic tetraplegia (HP:0002510)2.05090738
92Generalized aminoaciduria (HP:0002909)2.04388492
93Amelogenesis imperfecta (HP:0000705)2.02627101
94Drooling (HP:0002307)2.01525049
95Excessive salivation (HP:0003781)2.01525049
96Truncal ataxia (HP:0002078)2.01191360
97Optic nerve hypoplasia (HP:0000609)1.99615046
98Poor coordination (HP:0002370)1.97333197
99Absent speech (HP:0001344)1.97192943
100Muscular hypotonia of the trunk (HP:0008936)1.97035640
101Congenital glaucoma (HP:0001087)1.96928307
102Inability to walk (HP:0002540)1.96565973
103Neurofibrillary tangles (HP:0002185)1.95904708
104Progressive cerebellar ataxia (HP:0002073)1.95756582
105Hyperkalemia (HP:0002153)1.95340292
106Genetic anticipation (HP:0003743)1.93937133
107Prominent metopic ridge (HP:0005487)1.93262277
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92708210
109Abnormal eating behavior (HP:0100738)1.90462566
110Postural tremor (HP:0002174)1.90258997
111Cerebral inclusion bodies (HP:0100314)1.90214979
112Anencephaly (HP:0002323)1.90181980
113Hyperglycinemia (HP:0002154)1.90054196
114Gait imbalance (HP:0002141)1.89919162
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89270368
116Type II lissencephaly (HP:0007260)1.89059205
117Hypoplasia of the brainstem (HP:0002365)1.88759918
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88759918
119Neoplasm of the heart (HP:0100544)1.88512509
120Narrow forehead (HP:0000341)1.88170656
121Blue irides (HP:0000635)1.87758129
122Occipital encephalocele (HP:0002085)1.86748749
123Abnormality of the renal cortex (HP:0011035)1.86553047
124Resting tremor (HP:0002322)1.85055932
125Progressive macrocephaly (HP:0004481)1.83104011
126Growth hormone excess (HP:0000845)1.82536190
127Anophthalmia (HP:0000528)1.81288975
128Hyperventilation (HP:0002883)1.80984783
129Abolished electroretinogram (ERG) (HP:0000550)1.79751299
130Testicular neoplasm (HP:0010788)1.79312641
131Acute encephalopathy (HP:0006846)1.78756667
132Gaze-evoked nystagmus (HP:0000640)1.77639552
133Increased circulating renin level (HP:0000848)1.75495439
134Hepatoblastoma (HP:0002884)1.75332382
135Insulin resistance (HP:0000855)1.75278760
136Methylmalonic acidemia (HP:0002912)1.74940331
137Hyperphosphatemia (HP:0002905)1.74909814
138Oligomenorrhea (HP:0000876)1.74829894
139Unilateral renal agenesis (HP:0000122)1.74648592
140Protruding tongue (HP:0010808)1.74641991
141Psychosis (HP:0000709)1.74140480
142Akinesia (HP:0002304)1.72674515
143Cortical dysplasia (HP:0002539)1.72444644
144Clonus (HP:0002169)1.72230878
145Chronic bronchitis (HP:0004469)1.71530951
146Severe muscular hypotonia (HP:0006829)1.71346295
147Megalencephaly (HP:0001355)1.71268829
148Cerebellar dysplasia (HP:0007033)1.71151903
149Esotropia (HP:0000565)1.71077304
150Attenuation of retinal blood vessels (HP:0007843)1.70783057
151Postaxial hand polydactyly (HP:0001162)1.70736325
152Neoplasm of the peripheral nervous system (HP:0100007)1.70726125
153Bony spicule pigmentary retinopathy (HP:0007737)1.70539015
154Hypotension (HP:0002615)1.70184498
155Abnormality of the corticospinal tract (HP:0002492)1.70173546
156Neoplasm of the adrenal gland (HP:0100631)1.70093761
157Abnormal drinking behavior (HP:0030082)1.69850338
158Polydipsia (HP:0001959)1.69850338
159Mitochondrial inheritance (HP:0001427)1.69088363
160Febrile seizures (HP:0002373)1.69077307
161Progressive neurologic deterioration (HP:0002344)1.69052276
162Impaired smooth pursuit (HP:0007772)1.68479472
163Morphological abnormality of the pyramidal tract (HP:0002062)1.68461591
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.68328107
165Neoplasm of the adrenal cortex (HP:0100641)1.67597375
166Male pseudohermaphroditism (HP:0000037)1.67167760
167Exotropia (HP:0000577)1.66843154
168Abnormal mitochondria in muscle tissue (HP:0008316)1.66521233
169Abnormality of the metopic suture (HP:0005556)1.64701275
170Polymicrogyria (HP:0002126)1.64272071
171Partial agenesis of the corpus callosum (HP:0001338)1.62599197
172Hypomagnesemia (HP:0002917)1.61487638
173Sleep apnea (HP:0010535)1.61439047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.37854611
2MARK13.82067380
3NTRK33.81280820
4PASK3.54241437
5MAP3K22.88843345
6MAPK152.75665512
7PRKD32.60895045
8NTRK12.59331261
9MAP3K92.43076221
10HIPK22.32571228
11MAP3K42.27438513
12FRK2.18587232
13MAP2K72.08133595
14SCYL21.97919877
15WNK31.96561012
16UHMK11.90092572
17PINK11.84552087
18MINK11.81872092
19MAP4K21.81811742
20TAOK31.73115773
21CAMKK21.72541193
22ADRBK21.68465502
23WNK41.46914375
24NTRK21.41309785
25GRK11.39206315
26CAMKK11.37854751
27MAP3K11.37807889
28PAK31.35346321
29CDC42BPA1.33534802
30CSNK1G31.32536051
31KSR21.32367605
32TRIM281.29997294
33CASK1.28994660
34DAPK21.27982614
35AKT31.25930302
36MAP2K41.24404956
37GRK51.21970293
38CDK51.21968943
39PAK61.21547496
40CSNK1G11.16277684
41CSNK1A1L1.15617013
42ZAK1.15162604
43PRKCH1.14691499
44RET1.12416598
45MAP3K121.09880393
46ERBB31.07011918
47MAPK131.06191348
48OXSR10.99859400
49PRKCG0.98126453
50MKNK20.96167938
51FGFR20.95704833
52PRKCE0.94677325
53CDK190.94068557
54NUAK10.91931608
55STK390.91333874
56PLK20.88249014
57PHKG10.85681933
58PHKG20.85681933
59DYRK1A0.84758356
60PDGFRA0.83819971
61EPHB20.83201671
62RPS6KA20.81968149
63FLT30.78195147
64TYRO30.78045339
65SGK2230.77655787
66SGK4940.77655787
67EPHA40.77198033
68DAPK10.76336495
69DYRK30.76082566
70CSNK1G20.75851479
71FER0.74876141
72KSR10.73508877
73PTK20.71023181
74DYRK20.70844585
75EPHA30.70781069
76TLK10.70670528
77PKN10.70360289
78CAMK1D0.68761092
79ALK0.68334879
80SIK20.67261216
81STK38L0.66888812
82CAMK2A0.66473032
83PNCK0.66356765
84SGK20.66313543
85IRAK10.65590395
86MARK20.63447022
87BRAF0.63407899
88CAMK2D0.61438397
89LIMK10.59934200
90ARAF0.58284343
91BMPR20.57203861
92CSNK1E0.56476308
93TNIK0.55794494
94BCKDK0.54645126
95PRPF4B0.53802701
96CAMK2B0.52795930
97BRSK10.52331247
98PRKAA10.51879182
99BMPR1B0.51730873
100NME10.51276026
101CSNK1D0.50717370
102STK160.50526372
103CDK140.50484563
104BCR0.49000407
105IRAK20.48943644
106SGK10.48561076
107CAMK1G0.48310986
108VRK10.46827092
109RPS6KB10.46129729
110ERN10.45452775
111SGK30.44041684
112PRKCI0.43108839
113MAP2K10.42997907
114CAMK10.42338116
115CAMK40.42174804
116DYRK1B0.41217935
117WNK10.40873921
118PRKCZ0.40451603
119IRAK30.40068775
120PRKG10.40050538
121ADRBK10.39179769
122PLK30.37267167
123RPS6KA30.37101985
124CDK180.36294649
125PRKACG0.36184746
126CSNK1A10.36081916
127FES0.35998147
128CDK11A0.35855819
129STK110.35340358
130CDK150.34057998
131ACVR1B0.33909051
132TESK10.32351902
133PRKACA0.32326665
134MAP2K60.30831628
135PRKDC0.30495925
136TAOK10.29942941

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.77338269
2Protein export_Homo sapiens_hsa030603.35101521
3Insulin secretion_Homo sapiens_hsa049113.25123803
4Synaptic vesicle cycle_Homo sapiens_hsa047212.90370182
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78827014
6Phototransduction_Homo sapiens_hsa047442.47398143
7Vibrio cholerae infection_Homo sapiens_hsa051102.39781594
8Type II diabetes mellitus_Homo sapiens_hsa049302.25486799
9Sulfur metabolism_Homo sapiens_hsa009202.14698717
10Amphetamine addiction_Homo sapiens_hsa050312.11908058
11Cocaine addiction_Homo sapiens_hsa050302.06106121
12Parkinsons disease_Homo sapiens_hsa050122.01886490
13Type I diabetes mellitus_Homo sapiens_hsa049402.00165116
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99766634
15* GABAergic synapse_Homo sapiens_hsa047271.95681054
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91241403
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90019696
18Long-term potentiation_Homo sapiens_hsa047201.88992959
19Collecting duct acid secretion_Homo sapiens_hsa049661.84718215
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82694478
21* Circadian entrainment_Homo sapiens_hsa047131.78825054
22Taste transduction_Homo sapiens_hsa047421.78435275
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78204686
24Nicotine addiction_Homo sapiens_hsa050331.76023469
25* Dopaminergic synapse_Homo sapiens_hsa047281.73862325
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67317343
27* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58878166
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55264376
29* Morphine addiction_Homo sapiens_hsa050321.50630556
30* Cholinergic synapse_Homo sapiens_hsa047251.50389961
31Steroid biosynthesis_Homo sapiens_hsa001001.48853940
32Olfactory transduction_Homo sapiens_hsa047401.47274396
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44323979
34* Serotonergic synapse_Homo sapiens_hsa047261.36680471
35* Glutamatergic synapse_Homo sapiens_hsa047241.33283285
36Huntingtons disease_Homo sapiens_hsa050161.30180970
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25356214
38RNA polymerase_Homo sapiens_hsa030201.19913736
39Renin secretion_Homo sapiens_hsa049241.15595694
40N-Glycan biosynthesis_Homo sapiens_hsa005101.14462108
41Ether lipid metabolism_Homo sapiens_hsa005651.12186845
42Estrogen signaling pathway_Homo sapiens_hsa049151.11422082
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11160983
44Long-term depression_Homo sapiens_hsa047301.10619743
45Linoleic acid metabolism_Homo sapiens_hsa005911.09891847
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09749446
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08308767
48Gastric acid secretion_Homo sapiens_hsa049711.07923900
49Salivary secretion_Homo sapiens_hsa049701.07032679
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03766874
51Thyroid hormone synthesis_Homo sapiens_hsa049181.03533631
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02132475
53Propanoate metabolism_Homo sapiens_hsa006401.01542865
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00811909
55Pancreatic secretion_Homo sapiens_hsa049721.00282490
56Tryptophan metabolism_Homo sapiens_hsa003800.98851549
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98709957
58Basal transcription factors_Homo sapiens_hsa030220.97998588
59Glucagon signaling pathway_Homo sapiens_hsa049220.96293726
60Vitamin B6 metabolism_Homo sapiens_hsa007500.94770839
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93486775
62Lysosome_Homo sapiens_hsa041420.91905630
63Nitrogen metabolism_Homo sapiens_hsa009100.90159354
64Peroxisome_Homo sapiens_hsa041460.87090416
65Prion diseases_Homo sapiens_hsa050200.87011300
66GnRH signaling pathway_Homo sapiens_hsa049120.86820824
67Butanoate metabolism_Homo sapiens_hsa006500.86050401
68Gap junction_Homo sapiens_hsa045400.85408323
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84485231
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84323697
71Circadian rhythm_Homo sapiens_hsa047100.82669888
72cAMP signaling pathway_Homo sapiens_hsa040240.82449323
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80243928
74Oxytocin signaling pathway_Homo sapiens_hsa049210.80064562
75Regulation of autophagy_Homo sapiens_hsa041400.79984168
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77480787
77Prolactin signaling pathway_Homo sapiens_hsa049170.77269046
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77167992
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76733858
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74671021
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73694576
82Hedgehog signaling pathway_Homo sapiens_hsa043400.73003549
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72334282
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.72331789
85beta-Alanine metabolism_Homo sapiens_hsa004100.71431026
86Glioma_Homo sapiens_hsa052140.70919726
87RNA degradation_Homo sapiens_hsa030180.70517914
88Insulin signaling pathway_Homo sapiens_hsa049100.69566572
89Calcium signaling pathway_Homo sapiens_hsa040200.67000457
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66573612
91Melanogenesis_Homo sapiens_hsa049160.65319605
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.65248733
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64765951
94Fat digestion and absorption_Homo sapiens_hsa049750.64256619
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64047652
96Dorso-ventral axis formation_Homo sapiens_hsa043200.63911262
97Insulin resistance_Homo sapiens_hsa049310.63805964
98Fatty acid elongation_Homo sapiens_hsa000620.63503852
99Fanconi anemia pathway_Homo sapiens_hsa034600.63201571
100ErbB signaling pathway_Homo sapiens_hsa040120.61892734
101* Alcoholism_Homo sapiens_hsa050340.61368083
102Fatty acid metabolism_Homo sapiens_hsa012120.60241310
103Basal cell carcinoma_Homo sapiens_hsa052170.58367321
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57660908
105mTOR signaling pathway_Homo sapiens_hsa041500.56588067
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.56449529
107Endometrial cancer_Homo sapiens_hsa052130.54458219
108Hippo signaling pathway_Homo sapiens_hsa043900.53751599
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50999276
110Metabolic pathways_Homo sapiens_hsa011000.50827840
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49474325
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48872745
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46548403
114Phagosome_Homo sapiens_hsa041450.45959007
115Selenocompound metabolism_Homo sapiens_hsa004500.44929217
116Axon guidance_Homo sapiens_hsa043600.44463373
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44418589
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43554246
119Arginine and proline metabolism_Homo sapiens_hsa003300.42929047
120Purine metabolism_Homo sapiens_hsa002300.42008997
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.41785694
122Renal cell carcinoma_Homo sapiens_hsa052110.39427659
123Glycerolipid metabolism_Homo sapiens_hsa005610.39384458
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38694672
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38579501
126ABC transporters_Homo sapiens_hsa020100.38379692
127Galactose metabolism_Homo sapiens_hsa000520.37836622
128MAPK signaling pathway_Homo sapiens_hsa040100.37796128
129Wnt signaling pathway_Homo sapiens_hsa043100.37533877
130Alzheimers disease_Homo sapiens_hsa050100.37514832
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36566761
132Inositol phosphate metabolism_Homo sapiens_hsa005620.35611494
133AMPK signaling pathway_Homo sapiens_hsa041520.35001158
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34931696
135Retinol metabolism_Homo sapiens_hsa008300.34818364
136Endocytosis_Homo sapiens_hsa041440.34728281
137Ovarian steroidogenesis_Homo sapiens_hsa049130.34581710
138Oocyte meiosis_Homo sapiens_hsa041140.33894148
139Bile secretion_Homo sapiens_hsa049760.32599220
140Rheumatoid arthritis_Homo sapiens_hsa053230.32561757
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32033559
142Cardiac muscle contraction_Homo sapiens_hsa042600.31372958
143Oxidative phosphorylation_Homo sapiens_hsa001900.31154799
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.30378314
145Dilated cardiomyopathy_Homo sapiens_hsa054140.29747787
146Folate biosynthesis_Homo sapiens_hsa007900.29579460
147Fatty acid degradation_Homo sapiens_hsa000710.29043581
148Choline metabolism in cancer_Homo sapiens_hsa052310.28551913
149Other glycan degradation_Homo sapiens_hsa005110.27206724
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27189486
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.27170175

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »