GNG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925]. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.70158065
2viral transcription (GO:0019083)6.12101578
3ribosomal small subunit biogenesis (GO:0042274)5.87995970
4translational termination (GO:0006415)5.87895823
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.52640345
6cotranslational protein targeting to membrane (GO:0006613)5.41567945
7protein targeting to ER (GO:0045047)5.40275071
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.13363431
9protein localization to endoplasmic reticulum (GO:0070972)5.13135687
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.12265541
11chaperone-mediated protein transport (GO:0072321)5.08274726
12protein neddylation (GO:0045116)5.01158625
13translational elongation (GO:0006414)4.95040095
14DNA deamination (GO:0045006)4.65897479
15viral life cycle (GO:0019058)4.60482961
16maturation of SSU-rRNA (GO:0030490)4.52249632
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36455599
18cellular protein complex disassembly (GO:0043624)4.35056439
19protein complex biogenesis (GO:0070271)4.29343579
20translational initiation (GO:0006413)4.17380077
21mitochondrial respiratory chain complex assembly (GO:0033108)3.99854268
22ATP biosynthetic process (GO:0006754)3.85359927
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.79217316
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.79217316
25ribosomal large subunit biogenesis (GO:0042273)3.78940060
26purine nucleoside triphosphate biosynthetic process (GO:0009145)3.77823463
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.75366758
28protein complex disassembly (GO:0043241)3.67646271
29translation (GO:0006412)3.60346383
30protein targeting to mitochondrion (GO:0006626)3.58826566
31positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.53947054
32protein targeting to membrane (GO:0006612)3.51387623
33regulation of mitochondrial translation (GO:0070129)3.49045999
34macromolecular complex disassembly (GO:0032984)3.42492102
35hydrogen ion transmembrane transport (GO:1902600)3.42286258
36positive regulation of ligase activity (GO:0051351)3.39549640
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37483901
38ribonucleoside triphosphate biosynthetic process (GO:0009201)3.36349587
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33519153
40deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.33255726
41protein localization to mitochondrion (GO:0070585)3.32462655
42establishment of protein localization to mitochondrion (GO:0072655)3.29876758
43spliceosomal snRNP assembly (GO:0000387)3.23212013
44cullin deneddylation (GO:0010388)3.21688235
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.20100235
46proteasome assembly (GO:0043248)3.18511000
47nucleoside triphosphate biosynthetic process (GO:0009142)3.18433530
48cytochrome complex assembly (GO:0017004)3.18168372
49rRNA modification (GO:0000154)3.15999673
50regulation of ubiquitin-protein transferase activity (GO:0051438)3.11093591
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10359750
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07116122
53ATP synthesis coupled proton transport (GO:0015986)3.06613565
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06613565
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06548427
56mitochondrial transport (GO:0006839)3.06213194
57neutrophil activation involved in immune response (GO:0002283)3.05957141
58mRNA catabolic process (GO:0006402)3.05906186
59positive regulation of cell cycle arrest (GO:0071158)3.05107810
60deoxyribonucleotide catabolic process (GO:0009264)3.04123250
61establishment of integrated proviral latency (GO:0075713)3.03973456
62telomere maintenance via semi-conservative replication (GO:0032201)3.03946301
63deoxyribose phosphate catabolic process (GO:0046386)3.02280817
64protein deneddylation (GO:0000338)3.01395816
65regulation of ligase activity (GO:0051340)3.00851559
66proton transport (GO:0015992)3.00676309
67signal peptide processing (GO:0006465)2.99617674
68response to interferon-beta (GO:0035456)2.98147193
69purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.98054383
70purine nucleoside monophosphate biosynthetic process (GO:0009127)2.98054383
71ribonucleoprotein complex biogenesis (GO:0022613)2.94798611
72hydrogen transport (GO:0006818)2.94283086
73deoxyribose phosphate biosynthetic process (GO:0046385)2.93884382
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93870299
75RNA catabolic process (GO:0006401)2.82472069
76telomere maintenance via recombination (GO:0000722)2.77922399
77GTP biosynthetic process (GO:0006183)2.76796332
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70381037
79DNA strand elongation involved in DNA replication (GO:0006271)2.70308433
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62600371
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62000452
82DNA strand elongation (GO:0022616)2.60733334
83platelet dense granule organization (GO:0060155)2.56156835
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55742897
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55742897
86negative regulation of myeloid cell apoptotic process (GO:0033033)2.55667089
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52622875
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52622875
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52622875
90antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48608444
91formation of translation preinitiation complex (GO:0001731)2.48034651
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44954232
93UTP biosynthetic process (GO:0006228)2.44624751
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.43669525
95negative regulation of ligase activity (GO:0051352)2.43669525
96rRNA processing (GO:0006364)2.43403979
97regulation of cellular amino acid metabolic process (GO:0006521)2.42349809
98cellular component biogenesis (GO:0044085)2.42203948
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42092677
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41817000
101signal transduction involved in DNA integrity checkpoint (GO:0072401)2.40155615
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.40155615
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37058165
104mitotic recombination (GO:0006312)2.36133119
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35287922
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.35112128
107CENP-A containing nucleosome assembly (GO:0034080)2.34464928
108oxidative phosphorylation (GO:0006119)2.33628106
109rRNA metabolic process (GO:0016072)2.32507088
110regulation of metalloenzyme activity (GO:0048552)2.32249498
111establishment of protein localization to membrane (GO:0090150)2.32020730
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.29763568
113termination of RNA polymerase III transcription (GO:0006386)2.28908544
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.28908544
115UTP metabolic process (GO:0046051)2.28689545
116respiratory electron transport chain (GO:0022904)2.25197701
117CTP biosynthetic process (GO:0006241)2.24895215
118CTP metabolic process (GO:0046036)2.24895215
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.24580107
120production of molecular mediator involved in inflammatory response (GO:0002532)2.23127365
121electron transport chain (GO:0022900)2.20805874
122chromatin remodeling at centromere (GO:0031055)2.20269803
123protein targeting (GO:0006605)2.17463626
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.17081513
125guanosine-containing compound biosynthetic process (GO:1901070)2.15551648
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.15550440
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.14970093
128NADH dehydrogenase complex assembly (GO:0010257)2.14970093
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.14970093
130respiratory chain complex IV assembly (GO:0008535)2.14953727
131purine-containing compound salvage (GO:0043101)2.13931579
132daunorubicin metabolic process (GO:0044597)2.12741957
133polyketide metabolic process (GO:0030638)2.12741957
134doxorubicin metabolic process (GO:0044598)2.12741957
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.12580014
136aldehyde catabolic process (GO:0046185)2.11802526
137cellular response to interferon-beta (GO:0035458)2.09980815
138transcription-coupled nucleotide-excision repair (GO:0006283)2.08488414
139DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.08442187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80307762
2E2F7_22180533_ChIP-Seq_HELA_Human3.64350141
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.53754572
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37163601
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26893898
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.19553266
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02018040
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.94697016
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.82566360
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80634787
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.62300635
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60516475
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52301265
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45418464
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.43915833
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41974282
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.31340837
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28842586
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26744998
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15479439
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09476893
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06917370
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06809996
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04305778
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02250495
26VDR_23849224_ChIP-Seq_CD4+_Human2.01189325
27* ELK1_19687146_ChIP-ChIP_HELA_Human2.00185941
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98003864
29XRN2_22483619_ChIP-Seq_HELA_Human1.95895561
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93929513
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92084574
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89510183
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88987812
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88516458
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.88154384
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87978372
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87975876
38DCP1A_22483619_ChIP-Seq_HELA_Human1.86917792
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85698631
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.84578339
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79402956
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74097968
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70242478
44* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60914971
45* SPI1_23547873_ChIP-Seq_NB4_Human1.58612954
46TTF2_22483619_ChIP-Seq_HELA_Human1.53766154
47FOXP3_21729870_ChIP-Seq_TREG_Human1.53207233
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51441239
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49597519
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48110435
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.47252816
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43398463
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41770237
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41409509
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40139772
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.38354062
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36450097
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36012851
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34762948
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33406625
61* GABP_19822575_ChIP-Seq_HepG2_Human1.30400057
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29242375
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26261257
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.23765905
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22686213
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21721687
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20826965
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19883932
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16488823
70SCL_19346495_ChIP-Seq_HPC-7_Human1.16089868
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15801712
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15691714
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14685549
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13923686
75AR_21909140_ChIP-Seq_LNCAP_Human1.13345386
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12951566
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10523415
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.08520117
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07228472
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06928442
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05816663
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02305301
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01724796
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01465425
85NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98942823
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97978870
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97555975
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97437985
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96827259
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95661062
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95152777
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.95025318
93IRF8_27001747_Chip-Seq_BMDM_Mouse0.94908986
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94263315
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93805300
96* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93120532
97MYC_18940864_ChIP-ChIP_HL60_Human0.92194823
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.92030145
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91933149
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91523169
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91497693
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90844875
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90561736
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90159307
105MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89775837
106GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88804729
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.87961944
108VDR_21846776_ChIP-Seq_THP-1_Human0.87938783
109TFEB_21752829_ChIP-Seq_HELA_Human0.86949739
110VDR_24763502_ChIP-Seq_THP-1_Human0.86252622
111* MYB_26560356_Chip-Seq_TH2_Human0.86157760
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85046062
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84861847
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83889633
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83326203
116* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82801520
117KDM5A_27292631_Chip-Seq_BREAST_Human0.82450528
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.80263678
119* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77754581
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77524441
121VDR_22108803_ChIP-Seq_LS180_Human0.76512802
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75384867
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74011121
124ELF5_23300383_ChIP-Seq_T47D_Human0.73604325
125ERG_20517297_ChIP-Seq_VCAP_Human0.73599422
126EWS_26573619_Chip-Seq_HEK293_Human0.73134771
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72707933
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72194983
129AR_20517297_ChIP-Seq_VCAP_Human0.72176677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation2.98663854
2MP0006292_abnormal_olfactory_placode2.85877143
3MP0003186_abnormal_redox_activity2.63383276
4MP0008789_abnormal_olfactory_epithelium2.61427937
5MP0001835_abnormal_antigen_presentation2.55345022
6MP0009785_altered_susceptibility_to2.47596960
7MP0002148_abnormal_hypersensitivity_rea2.43384175
8MP0003724_increased_susceptibility_to2.29641784
9MP0003436_decreased_susceptibility_to2.14255890
10MP0003693_abnormal_embryo_hatching2.04070371
11MP0001853_heart_inflammation1.97548636
12MP0003806_abnormal_nucleotide_metabolis1.93149897
13MP0006072_abnormal_retinal_apoptosis1.90804337
14MP0000685_abnormal_immune_system1.83310475
15MP0005025_abnormal_response_to1.82028543
16MP0002163_abnormal_gland_morphology1.78533172
17MP0001529_abnormal_vocalization1.78473993
18MP0002837_dystrophic_cardiac_calcinosis1.70467336
19MP0002132_abnormal_respiratory_system1.68254021
20MP0005000_abnormal_immune_tolerance1.67164335
21MP0003718_maternal_effect1.63296548
22MP0004957_abnormal_blastocyst_morpholog1.63146544
23MP0002419_abnormal_innate_immunity1.62962546
24MP0005671_abnormal_response_to1.59774984
25MP0006054_spinal_hemorrhage1.59613714
26MP0005394_taste/olfaction_phenotype1.57545869
27MP0005499_abnormal_olfactory_system1.57545869
28MP0002653_abnormal_ependyma_morphology1.53833182
29MP0009333_abnormal_splenocyte_physiolog1.52867696
30MP0000490_abnormal_crypts_of1.52508398
31MP0006035_abnormal_mitochondrial_morpho1.51898717
32MP0001293_anophthalmia1.51504701
33MP0004147_increased_porphyrin_level1.47959077
34MP0008007_abnormal_cellular_replicative1.46117345
35MP0002405_respiratory_system_inflammati1.45565585
36MP0002452_abnormal_antigen_presenting1.42956028
37MP0005084_abnormal_gallbladder_morpholo1.41817836
38MP0000343_altered_response_to1.39183684
39MP0005408_hypopigmentation1.37056956
40MP0001879_abnormal_lymphatic_vessel1.35258681
41MP0002166_altered_tumor_susceptibility1.34573116
42MP0002723_abnormal_immune_serum1.33632436
43MP0003077_abnormal_cell_cycle1.30725155
44MP0002006_tumorigenesis1.29894593
45MP0003011_delayed_dark_adaptation1.29783643
46MP0006082_CNS_inflammation1.29767569
47MP0001800_abnormal_humoral_immune1.29317725
48MP0002396_abnormal_hematopoietic_system1.29237245
49MP0001819_abnormal_immune_cell1.28695174
50MP0005367_renal/urinary_system_phenotyp1.28691926
51MP0000516_abnormal_urinary_system1.28691926
52MP0002420_abnormal_adaptive_immunity1.28503683
53MP0010155_abnormal_intestine_physiology1.27030164
54MP0005387_immune_system_phenotype1.24097767
55MP0001790_abnormal_immune_system1.24097767
56MP0002938_white_spotting1.22017756
57MP0005397_hematopoietic_system_phenotyp1.21657970
58MP0001545_abnormal_hematopoietic_system1.21657970
59MP0002090_abnormal_vision1.19116059
60MP0008995_early_reproductive_senescence1.18508831
61MP0001845_abnormal_inflammatory_respons1.16931267
62MP0008469_abnormal_protein_level1.16883838
63MP0005464_abnormal_platelet_physiology1.16620210
64MP0008932_abnormal_embryonic_tissue1.15824526
65MP0003763_abnormal_thymus_physiology1.14683372
66MP0003136_yellow_coat_color1.14595454
67MP0010368_abnormal_lymphatic_system1.13984936
68MP0000858_altered_metastatic_potential1.13229125
69MP0001533_abnormal_skeleton_physiology1.13033379
70MP0000372_irregular_coat_pigmentation1.12428291
71MP0002095_abnormal_skin_pigmentation1.10282652
72MP0002933_joint_inflammation1.10228419
73MP0009764_decreased_sensitivity_to1.06506909
74MP0002398_abnormal_bone_marrow1.04248956
75MP0002234_abnormal_pharynx_morphology1.04154659
76MP0003195_calcinosis1.03711804
77MP0004145_abnormal_muscle_electrophysio1.03041950
78MP0000689_abnormal_spleen_morphology1.03024845
79MP0000716_abnormal_immune_system1.03012387
80MP0009697_abnormal_copulation1.02946858
81MP0003828_pulmonary_edema1.01774458
82MP0002722_abnormal_immune_system1.01620828
83MP0000358_abnormal_cell_content/1.00997393
84MP0002429_abnormal_blood_cell1.00725263
85MP0004808_abnormal_hematopoietic_stem1.00294130
86MP0002102_abnormal_ear_morphology1.00086532
87MP0010094_abnormal_chromosome_stability0.99147337
88MP0004782_abnormal_surfactant_physiolog0.98410925
89MP0001542_abnormal_bone_strength0.97707136
90MP0008875_abnormal_xenobiotic_pharmacok0.97325703
91MP0005253_abnormal_eye_physiology0.95896313
92MP0001873_stomach_inflammation0.95874051
93MP0000465_gastrointestinal_hemorrhage0.95676938
94MP0001727_abnormal_embryo_implantation0.94648966
95MP0005319_abnormal_enzyme/_coenzyme0.94515423
96MP0005023_abnormal_wound_healing0.93592279
97MP0010030_abnormal_orbit_morphology0.93210460
98MP0003941_abnormal_skin_development0.92790543
99MP0003786_premature_aging0.91216082
100MP0005636_abnormal_mineral_homeostasis0.90961776
101MP0005332_abnormal_amino_acid0.88601391
102MP0005379_endocrine/exocrine_gland_phen0.87452676
103MP0003646_muscle_fatigue0.86992128
104MP0004381_abnormal_hair_follicle0.86110046
105MP0002282_abnormal_trachea_morphology0.85556316
106MP0006036_abnormal_mitochondrial_physio0.82852279
107MP0002098_abnormal_vibrissa_morphology0.82032151
108MP0005390_skeleton_phenotype0.81640185
109MP0002138_abnormal_hepatobiliary_system0.81115002
110MP0005075_abnormal_melanosome_morpholog0.80753950
111MP0000313_abnormal_cell_death0.79494675
112MP0003279_aneurysm0.79308250
113MP0003656_abnormal_erythrocyte_physiolo0.78906830
114MP0004142_abnormal_muscle_tone0.78885302
115MP0008057_abnormal_DNA_replication0.77872998
116MP0002139_abnormal_hepatobiliary_system0.77456225
117MP0009384_cardiac_valve_regurgitation0.77203278
118MP0005330_cardiomyopathy0.77164275
119MP0002019_abnormal_tumor_incidence0.76468441
120MP0005174_abnormal_tail_pigmentation0.76019720
121MP0004019_abnormal_vitamin_homeostasis0.75101228
122MP0005451_abnormal_body_composition0.74462526
123MP0004947_skin_inflammation0.74348653
124MP0005085_abnormal_gallbladder_physiolo0.73819879
125MP0000749_muscle_degeneration0.72936830
126MP0008058_abnormal_DNA_repair0.71431174
127MP0002277_abnormal_respiratory_mucosa0.70978821
128MP0002210_abnormal_sex_determination0.70843805
129MP0003567_abnormal_fetal_cardiomyocyte0.70599003
130MP0003315_abnormal_perineum_morphology0.70148668
131MP0001905_abnormal_dopamine_level0.70132588
132MP0003448_altered_tumor_morphology0.69954704
133MP0000049_abnormal_middle_ear0.69918658
134MP0001764_abnormal_homeostasis0.69837894
135MP0009643_abnormal_urine_homeostasis0.68969614
136MP0005083_abnormal_biliary_tract0.68542789
137MP0003137_abnormal_impulse_conducting0.68349727
138MP0001881_abnormal_mammary_gland0.68311741
139MP0009763_increased_sensitivity_to0.68103234
140MP0005058_abnormal_lysosome_morphology0.67711264
141MP0003111_abnormal_nucleus_morphology0.66880033
142MP0005165_increased_susceptibility_to0.66503663
143MP0004133_heterotaxia0.64864208
144MP0005389_reproductive_system_phenotype0.64636056
145MP0002233_abnormal_nose_morphology0.63769408

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.40740681
2Reticulocytopenia (HP:0001896)5.11367472
3Abnormal number of erythroid precursors (HP:0012131)5.04124192
4Macrocytic anemia (HP:0001972)3.51658787
5Recurrent abscess formation (HP:0002722)3.36199632
6Pallor (HP:0000980)3.34870819
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.34756993
8Acute necrotizing encephalopathy (HP:0006965)2.93483711
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92247289
10Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92247289
11Increased serum pyruvate (HP:0003542)2.90816835
12Leukodystrophy (HP:0002415)2.85227198
13Increased hepatocellular lipid droplets (HP:0006565)2.84639988
14Reduced antithrombin III activity (HP:0001976)2.83880409
15Type I transferrin isoform profile (HP:0003642)2.82482704
1611 pairs of ribs (HP:0000878)2.81564594
17Recurrent bacterial skin infections (HP:0005406)2.81499865
18Exertional dyspnea (HP:0002875)2.79449772
19Aplastic anemia (HP:0001915)2.77819834
20Mitochondrial inheritance (HP:0001427)2.77566301
21Degeneration of anterior horn cells (HP:0002398)2.75602656
22Abnormality of the anterior horn cell (HP:0006802)2.75602656
23Optic disc pallor (HP:0000543)2.75462660
24Elevated erythrocyte sedimentation rate (HP:0003565)2.74864021
25Lipid accumulation in hepatocytes (HP:0006561)2.73239462
26Abnormal mitochondria in muscle tissue (HP:0008316)2.62839611
27Hepatic necrosis (HP:0002605)2.62065829
28Lethargy (HP:0001254)2.61710375
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60811512
30Renal Fanconi syndrome (HP:0001994)2.59400709
31Petechiae (HP:0000967)2.54835377
32Hyperglycinemia (HP:0002154)2.52127752
33Thrombocytosis (HP:0001894)2.51842055
34Acute encephalopathy (HP:0006846)2.41546918
35Eczematoid dermatitis (HP:0000976)2.40458145
36Microvesicular hepatic steatosis (HP:0001414)2.39609841
37Hepatocellular necrosis (HP:0001404)2.39483974
38CNS demyelination (HP:0007305)2.37742142
39Abnormality of glycolysis (HP:0004366)2.37548313
40Poor head control (HP:0002421)2.36060317
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34684256
42Congenital, generalized hypertrichosis (HP:0004540)2.32809458
433-Methylglutaconic aciduria (HP:0003535)2.31545532
44Generalized aminoaciduria (HP:0002909)2.29090047
45Increased CSF lactate (HP:0002490)2.28936111
46Abnormal hemoglobin (HP:0011902)2.23006323
47Increased intramyocellular lipid droplets (HP:0012240)2.22676749
48Nausea (HP:0002018)2.22587248
49Abnormality of secondary sexual hair (HP:0009888)2.21509953
50Abnormality of the axillary hair (HP:0100134)2.21509953
51Exercise intolerance (HP:0003546)2.19749730
52Vacuolated lymphocytes (HP:0001922)2.18595151
53Progressive macrocephaly (HP:0004481)2.16354332
54X-linked dominant inheritance (HP:0001423)2.16016724
55Mediastinal lymphadenopathy (HP:0100721)2.14765904
56Increased muscle lipid content (HP:0009058)2.12135713
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11185392
58Abnormal protein N-linked glycosylation (HP:0012347)2.11185392
59Abnormal protein glycosylation (HP:0012346)2.11185392
60Abnormal glycosylation (HP:0012345)2.11185392
61Abnormality of macrophages (HP:0004311)2.06769639
62Recurrent gram-negative bacterial infections (HP:0005420)2.06527645
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05247327
64Dicarboxylic aciduria (HP:0003215)2.05247327
65Myositis (HP:0100614)2.03625097
66Methylmalonic acidemia (HP:0002912)2.02740287
67Methylmalonic aciduria (HP:0012120)2.02358936
68Molar tooth sign on MRI (HP:0002419)1.98876462
69Abnormality of midbrain morphology (HP:0002418)1.98876462
70Emotional lability (HP:0000712)1.96607988
71Abnormality of serum amino acid levels (HP:0003112)1.96463717
72Glycosuria (HP:0003076)1.90364169
73Abnormality of urine glucose concentration (HP:0011016)1.90364169
74IgM deficiency (HP:0002850)1.89577486
75Cleft eyelid (HP:0000625)1.89480469
76Respiratory difficulties (HP:0002880)1.86685479
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85355776
78True hermaphroditism (HP:0010459)1.81436411
79Cerebral edema (HP:0002181)1.81173658
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80170150
81Microretrognathia (HP:0000308)1.80146750
82Sparse eyelashes (HP:0000653)1.79353533
83Respiratory failure (HP:0002878)1.78792839
84Multiple enchondromatosis (HP:0005701)1.77768485
85Muscle fiber atrophy (HP:0100295)1.77668924
86Oral leukoplakia (HP:0002745)1.76233392
87Pancreatic fibrosis (HP:0100732)1.76177367
88Median cleft lip (HP:0000161)1.75850884
89Pancreatic cysts (HP:0001737)1.75651653
90Increased serum lactate (HP:0002151)1.75188339
91Colon cancer (HP:0003003)1.75169308
92Abnormality of reticulocytes (HP:0004312)1.75096728
93Sclerocornea (HP:0000647)1.74699862
94Abnormality of alanine metabolism (HP:0010916)1.73892123
95Hyperalaninemia (HP:0003348)1.73892123
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73892123
97Blindness (HP:0000618)1.73456291
98Metaphyseal dysplasia (HP:0100255)1.73002921
99Recurrent skin infections (HP:0001581)1.72521593
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71547886
101Abnormality of methionine metabolism (HP:0010901)1.69510782
102Vomiting (HP:0002013)1.67529620
103Hepatosplenomegaly (HP:0001433)1.67107836
104Type 2 muscle fiber atrophy (HP:0003554)1.67063629
105Partial duplication of thumb phalanx (HP:0009944)1.65235953
106Palpitations (HP:0001962)1.64819392
107Carpal bone hypoplasia (HP:0001498)1.64020285
108Abnormality of T cell physiology (HP:0011840)1.63959382
109Abnormality of renal resorption (HP:0011038)1.63818436
110Medial flaring of the eyebrow (HP:0010747)1.62460140
111Pustule (HP:0200039)1.61949750
112Increased IgM level (HP:0003496)1.61383652
113Parakeratosis (HP:0001036)1.59209432
114Rough bone trabeculation (HP:0100670)1.58631612
115Hyperglycinuria (HP:0003108)1.58169871
116Lactic acidosis (HP:0003128)1.57503125
117Autoimmune thrombocytopenia (HP:0001973)1.56717184
118Orchitis (HP:0100796)1.55794594
119Abnormality of glycine metabolism (HP:0010895)1.55629281
120Pulmonary artery stenosis (HP:0004415)1.54772233
121Trismus (HP:0000211)1.53333913
122Hypoglycemic coma (HP:0001325)1.53249309
123Chronic obstructive pulmonary disease (HP:0006510)1.52368788
124Obstructive lung disease (HP:0006536)1.52368788
125Pancytopenia (HP:0001876)1.51562064
126Stenosis of the external auditory canal (HP:0000402)1.51249960
127Congenital ichthyosiform erythroderma (HP:0007431)1.51157431
128Urticaria (HP:0001025)1.50309236
129Partial duplication of the phalanx of hand (HP:0009999)1.49517597
130Abnormality of the columella (HP:0009929)1.48641363
131Rhabdomyolysis (HP:0003201)1.48634553
132Abnormality of placental membranes (HP:0011409)1.47490925
133Amniotic constriction ring (HP:0009775)1.47490925
134Hyperphosphaturia (HP:0003109)1.47303565
135Beaking of vertebral bodies (HP:0004568)1.47051893
136Autoimmune hemolytic anemia (HP:0001890)1.45985205
137Irregular epiphyses (HP:0010582)1.45575573
138Proximal tubulopathy (HP:0000114)1.45218737
139Absent thumb (HP:0009777)1.44825693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.99727057
2NME24.06436391
3NEK12.93539344
4PBK2.85706820
5PIM22.64326415
6MAP3K122.51788101
7STK162.38260404
8KDR2.35452098
9WEE12.21703125
10MST42.14261155
11EIF2AK32.13772815
12BUB12.07692097
13EIF2AK11.98190676
14VRK11.95384217
15ACVR1B1.81810060
16IRAK41.72227844
17CDK191.70999386
18TEC1.69944383
19OBSCN1.53466091
20MYLK1.52815988
21TRIM281.52543199
22TESK11.49597856
23IRAK31.48818656
24TBK11.48017866
25MKNK11.46873520
26LRRK21.43839808
27BLK1.42652308
28PDK21.42538640
29RPS6KA41.39730970
30NME11.38739173
31BRSK21.36550979
32IKBKB1.33678956
33MAP4K21.31848839
34NLK1.31178836
35PLK41.31092314
36BTK1.30213802
37BCKDK1.28595208
38PLK31.26883517
39MAP3K141.25536699
40MAP3K31.25466614
41MAP3K111.24112502
42ZAK1.23995199
43KIT1.23408289
44TYK21.23072862
45PIK3CG1.20083789
46RPS6KB21.19555760
47TESK21.18804280
48TGFBR11.17620428
49MAP4K11.16834796
50DYRK31.16254687
51MAP2K31.13566653
52TIE11.13310502
53TLK11.12436158
54MUSK1.12007767
55CCNB11.11416816
56ABL21.10389236
57MAPK151.08752371
58IKBKE1.08199199
59DYRK21.07931704
60STK101.07797011
61SRPK11.07659177
62EIF2AK21.06864784
63JAK31.05657001
64CSNK1G31.05181181
65PIM11.02990249
66FLT31.01713990
67ERN10.96875964
68TXK0.96093030
69NEK90.94912497
70ARAF0.93225766
71TTK0.92962757
72AURKB0.92721372
73DAPK30.91451594
74STK40.91410666
75LIMK10.88683253
76TAF10.87735253
77BMPR20.86672472
78WNK30.86092665
79CDK70.85393046
80ILK0.84348182
81BCR0.84095698
82CSNK1G10.79506979
83CDK80.79035806
84STK240.77383630
85ZAP700.76913161
86TGFBR20.76836470
87PRKG20.75494137
88PAK40.75312659
89NUAK10.74419373
90RPS6KA50.73192192
91GRK70.73008903
92CHEK20.71266426
93LYN0.71234035
94TRPM70.71168612
95CSNK1G20.70961793
96CSNK1A1L0.70860039
97EPHB20.68603209
98MAP2K20.67911270
99CSNK2A20.67484260
100BMPR1B0.65906445
101MAP3K80.64947403
102SIK30.64658669
103DAPK10.62701874
104PASK0.61061639
105ERBB30.60506262
106CHUK0.59648595
107MOS0.59479913
108MKNK20.57891726
109CSNK2A10.57060207
110PIK3CA0.56753988
111ATR0.56161956
112YES10.55146979
113GRK10.52530564
114MAPKAPK50.52327061
115WNK40.52316062
116PLK10.51708631
117MATK0.50696558
118CLK10.50067282
119DYRK1B0.49694831
120IRAK10.48332300
121BRSK10.48181502
122NEK20.48168582
123ADRBK20.47959310
124MAPKAPK20.46985857
125PAK10.46945183
126MAPKAPK30.46614249
127TAOK20.45882691
128STK390.42235226
129LCK0.41932775
130CDC70.41641720
131EPHA20.41603473
132AURKA0.41167664
133TNIK0.40505352
134BRAF0.36167010
135PLK20.32200638
136OXSR10.30324760
137CSF1R0.28947674
138DMPK0.28412867
139CDK140.27758238

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.16702218
2Proteasome_Homo sapiens_hsa030503.24133197
3DNA replication_Homo sapiens_hsa030302.91329808
4Protein export_Homo sapiens_hsa030602.77767063
5Mismatch repair_Homo sapiens_hsa034302.31927426
6RNA polymerase_Homo sapiens_hsa030202.28971293
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11104688
8Oxidative phosphorylation_Homo sapiens_hsa001902.06831336
9Homologous recombination_Homo sapiens_hsa034402.01393210
10Pyrimidine metabolism_Homo sapiens_hsa002401.97019193
11Parkinsons disease_Homo sapiens_hsa050121.95557030
12Spliceosome_Homo sapiens_hsa030401.83721184
13Nucleotide excision repair_Homo sapiens_hsa034201.69750891
14Base excision repair_Homo sapiens_hsa034101.60288387
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54233247
16Huntingtons disease_Homo sapiens_hsa050161.47709333
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43812295
18Folate biosynthesis_Homo sapiens_hsa007901.33449741
19Glutathione metabolism_Homo sapiens_hsa004801.30365192
20Propanoate metabolism_Homo sapiens_hsa006401.28436607
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26814242
22Legionellosis_Homo sapiens_hsa051341.26036464
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24824495
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20974715
25Alzheimers disease_Homo sapiens_hsa050101.17642144
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14911864
27One carbon pool by folate_Homo sapiens_hsa006701.11058817
28Leishmaniasis_Homo sapiens_hsa051401.10919402
29Graft-versus-host disease_Homo sapiens_hsa053321.10397658
30RNA degradation_Homo sapiens_hsa030181.09727245
31Allograft rejection_Homo sapiens_hsa053301.09075528
32Basal transcription factors_Homo sapiens_hsa030221.06527649
33Asthma_Homo sapiens_hsa053101.05871811
34Pyruvate metabolism_Homo sapiens_hsa006201.05503013
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05403453
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02694391
37Arachidonic acid metabolism_Homo sapiens_hsa005901.01801056
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00726191
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99723304
40Fanconi anemia pathway_Homo sapiens_hsa034600.99240775
41RNA transport_Homo sapiens_hsa030130.99076219
42Herpes simplex infection_Homo sapiens_hsa051680.98677325
43Malaria_Homo sapiens_hsa051440.97974633
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.97898486
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97028204
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.96834992
47p53 signaling pathway_Homo sapiens_hsa041150.96365822
48Cell cycle_Homo sapiens_hsa041100.95782355
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92881768
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.91599385
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90247999
52Hematopoietic cell lineage_Homo sapiens_hsa046400.89475494
53Sulfur relay system_Homo sapiens_hsa041220.89447394
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88782196
55Purine metabolism_Homo sapiens_hsa002300.88574280
56Antigen processing and presentation_Homo sapiens_hsa046120.87334941
57Other glycan degradation_Homo sapiens_hsa005110.87315104
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85511406
59Type I diabetes mellitus_Homo sapiens_hsa049400.85471586
60Carbon metabolism_Homo sapiens_hsa012000.83391914
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82979627
62Sulfur metabolism_Homo sapiens_hsa009200.81228556
63Caffeine metabolism_Homo sapiens_hsa002320.80050153
64Staphylococcus aureus infection_Homo sapiens_hsa051500.79816208
65Non-homologous end-joining_Homo sapiens_hsa034500.79641304
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78733956
67Systemic lupus erythematosus_Homo sapiens_hsa053220.77457524
68Pertussis_Homo sapiens_hsa051330.76395889
69Pentose phosphate pathway_Homo sapiens_hsa000300.75725592
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75410000
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75307162
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75229461
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.74942588
74Measles_Homo sapiens_hsa051620.74202758
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73135893
76Primary immunodeficiency_Homo sapiens_hsa053400.73003552
77Chemical carcinogenesis_Homo sapiens_hsa052040.72513101
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72447884
79Epstein-Barr virus infection_Homo sapiens_hsa051690.67240500
80Viral myocarditis_Homo sapiens_hsa054160.65540285
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61470642
82Linoleic acid metabolism_Homo sapiens_hsa005910.61338542
83Biosynthesis of amino acids_Homo sapiens_hsa012300.59832471
84Fatty acid elongation_Homo sapiens_hsa000620.59428038
85Steroid biosynthesis_Homo sapiens_hsa001000.59254807
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58805518
87Apoptosis_Homo sapiens_hsa042100.57937739
88Peroxisome_Homo sapiens_hsa041460.57198426
89Galactose metabolism_Homo sapiens_hsa000520.57119977
90Autoimmune thyroid disease_Homo sapiens_hsa053200.56509452
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.56162006
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54336142
93Collecting duct acid secretion_Homo sapiens_hsa049660.52455250
94Shigellosis_Homo sapiens_hsa051310.51142174
95Metabolic pathways_Homo sapiens_hsa011000.49764153
96Fatty acid degradation_Homo sapiens_hsa000710.48993083
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48904697
98Influenza A_Homo sapiens_hsa051640.48726562
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48239786
100Retinol metabolism_Homo sapiens_hsa008300.46565913
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.45748622
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44261499
103Histidine metabolism_Homo sapiens_hsa003400.43998788
104Salmonella infection_Homo sapiens_hsa051320.42809039
105Rheumatoid arthritis_Homo sapiens_hsa053230.41277475
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.41010307
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40955645
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.40653215
109Cardiac muscle contraction_Homo sapiens_hsa042600.40373402
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39852311
111Tryptophan metabolism_Homo sapiens_hsa003800.39431820
112Selenocompound metabolism_Homo sapiens_hsa004500.39352948
113TNF signaling pathway_Homo sapiens_hsa046680.38482710
114N-Glycan biosynthesis_Homo sapiens_hsa005100.38166518
115Arginine and proline metabolism_Homo sapiens_hsa003300.37684883
116Fatty acid metabolism_Homo sapiens_hsa012120.36211365
117Phenylalanine metabolism_Homo sapiens_hsa003600.35553170
118Small cell lung cancer_Homo sapiens_hsa052220.34320457
119Tyrosine metabolism_Homo sapiens_hsa003500.34261792
120Viral carcinogenesis_Homo sapiens_hsa052030.33115521
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32479345
122Butanoate metabolism_Homo sapiens_hsa006500.28369610
123Regulation of autophagy_Homo sapiens_hsa041400.27784011
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25137187
125beta-Alanine metabolism_Homo sapiens_hsa004100.24968203
126Phagosome_Homo sapiens_hsa041450.23982189
127Fat digestion and absorption_Homo sapiens_hsa049750.21919500

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