GNG5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.51396964
2ribosomal small subunit assembly (GO:0000028)5.18092531
3behavioral response to nicotine (GO:0035095)5.02149807
4cornea development in camera-type eye (GO:0061303)4.89584880
5neuron recognition (GO:0008038)4.88124933
6axon ensheathment in central nervous system (GO:0032291)4.63816923
7central nervous system myelination (GO:0022010)4.63816923
8regulation of vacuole organization (GO:0044088)4.59039448
9response to redox state (GO:0051775)4.56403752
10protein neddylation (GO:0045116)4.52584277
11nucleobase catabolic process (GO:0046113)4.43448937
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.41535463
13substrate-independent telencephalic tangential migration (GO:0021826)4.41535463
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41493040
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39753499
16viral transcription (GO:0019083)4.12636998
17peptidyl-threonine dephosphorylation (GO:0035970)4.11120022
18axonal fasciculation (GO:0007413)4.09579016
19positive regulation of gastrulation (GO:2000543)4.03382533
20translational termination (GO:0006415)3.96018127
21response to pheromone (GO:0019236)3.86009054
22protein complex biogenesis (GO:0070271)3.84313235
23regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.84046926
24forebrain neuron development (GO:0021884)3.83600832
25regulation of autophagic vacuole assembly (GO:2000785)3.81674464
26positive regulation of neurological system process (GO:0031646)3.78931686
27chaperone-mediated protein transport (GO:0072321)3.60470613
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59697251
29ATP synthesis coupled proton transport (GO:0015986)3.59697251
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51129033
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.51129033
32NADH dehydrogenase complex assembly (GO:0010257)3.51129033
33epithelial cilium movement (GO:0003351)3.50803661
34ncRNA 3-end processing (GO:0043628)3.46735280
35ribosomal small subunit biogenesis (GO:0042274)3.46270289
36cochlea development (GO:0090102)3.45507115
37translational elongation (GO:0006414)3.40724499
38mitochondrial respiratory chain complex assembly (GO:0033108)3.36761508
39dendritic spine morphogenesis (GO:0060997)3.36017620
40keratinocyte development (GO:0003334)3.35869858
41nephron epithelium morphogenesis (GO:0072088)3.34681332
42nephron tubule morphogenesis (GO:0072078)3.34681332
43adaptation of signaling pathway (GO:0023058)3.30765912
44cotranslational protein targeting to membrane (GO:0006613)3.28349135
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24791121
46protein targeting to ER (GO:0045047)3.24331387
47cellular ketone body metabolic process (GO:0046950)3.22876407
48positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.22152754
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.20096229
50GTP biosynthetic process (GO:0006183)3.20046705
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19315162
52somite development (GO:0061053)3.18972944
53protein localization to endoplasmic reticulum (GO:0070972)3.18557405
54positive regulation of protein homooligomerization (GO:0032464)3.17684511
55regulation of glutamate receptor signaling pathway (GO:1900449)3.17634946
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16160743
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14068687
58transmission of nerve impulse (GO:0019226)3.11829104
59collecting duct development (GO:0072044)3.08015455
60intraciliary transport (GO:0042073)3.05769695
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05068770
62respiratory electron transport chain (GO:0022904)3.04316228
63response to dietary excess (GO:0002021)3.01220030
64electron transport chain (GO:0022900)3.00923409
65respiratory chain complex IV assembly (GO:0008535)3.00149359
66viral life cycle (GO:0019058)2.99186188
67cellular protein complex disassembly (GO:0043624)2.99145138
68centrosome localization (GO:0051642)2.97155861
69protein polyglutamylation (GO:0018095)2.97026314
70protein localization to cilium (GO:0061512)2.96368224
71central nervous system neuron development (GO:0021954)2.95113039
72head development (GO:0060322)2.93940226
73peripheral nervous system axon ensheathment (GO:0032292)2.89210556
74myelination in peripheral nervous system (GO:0022011)2.89210556
75body morphogenesis (GO:0010171)2.88141694
76positive regulation of T cell apoptotic process (GO:0070234)2.86030062
77isoprenoid biosynthetic process (GO:0008299)2.85950918
78maturation of SSU-rRNA (GO:0030490)2.85950521
79ketone body metabolic process (GO:1902224)2.85684962
80embryonic body morphogenesis (GO:0010172)2.83443106
81UTP biosynthetic process (GO:0006228)2.83049416
82negative regulation of neurotransmitter secretion (GO:0046929)2.81771121
83cholesterol biosynthetic process (GO:0006695)2.80225579
84cilium movement (GO:0003341)2.78753801
85establishment of epithelial cell polarity (GO:0090162)2.77805392
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75945095
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74731743
88cytochrome complex assembly (GO:0017004)2.72663262
89retinal ganglion cell axon guidance (GO:0031290)2.71759185
90CENP-A containing nucleosome assembly (GO:0034080)2.71603509
91negative regulation of glucose import (GO:0046325)2.71308253
92lipopolysaccharide biosynthetic process (GO:0009103)2.71052944
93presynaptic membrane organization (GO:0097090)2.70254794
94cell proliferation in forebrain (GO:0021846)2.70146851
95Sertoli cell development (GO:0060009)2.66330534
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66137230
97neuron migration (GO:0001764)2.65707050
98nonmotile primary cilium assembly (GO:0035058)2.64228720
99regulation of action potential (GO:0098900)2.63192462
100chromatin remodeling at centromere (GO:0031055)2.62128485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.53976875
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.25697146
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06180924
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.04654335
5IGF1R_20145208_ChIP-Seq_DFB_Human2.86628611
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.64774930
7VDR_22108803_ChIP-Seq_LS180_Human2.62959523
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49665631
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34013482
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31170258
11GBX2_23144817_ChIP-Seq_PC3_Human2.28057199
12SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20919826
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.15340275
14REST_21632747_ChIP-Seq_MESCs_Mouse2.07851560
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.07413414
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.98609222
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.89493622
18IRF1_19129219_ChIP-ChIP_H3396_Human1.88675850
19ZNF274_21170338_ChIP-Seq_K562_Hela1.88526092
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86669886
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86107023
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85970538
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85970538
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85635944
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.80826735
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77375997
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.76681302
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70626750
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66637785
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63821172
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52429758
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50546916
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48554092
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44972683
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.44513138
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42714132
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41676797
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.40906623
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33816962
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33416873
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31004759
42RNF2_27304074_Chip-Seq_NSC_Mouse1.28579066
43TP53_22573176_ChIP-Seq_HFKS_Human1.27054747
44DROSHA_22980978_ChIP-Seq_HELA_Human1.26804738
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26624070
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23074561
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22085372
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.17569301
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15961862
50CTCF_27219007_Chip-Seq_Bcells_Human1.15036398
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10082083
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09696390
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06815220
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05825108
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04870513
56REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01499476
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00897456
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00346820
59P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99423400
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99058405
61SMAD3_21741376_ChIP-Seq_ESCs_Human0.98772691
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97732299
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95040794
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94874670
65BCAT_22108803_ChIP-Seq_LS180_Human0.94719255
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94493472
67EST1_17652178_ChIP-ChIP_JURKAT_Human0.94381613
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94078720
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92172556
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90401195
71ETS1_20019798_ChIP-Seq_JURKAT_Human0.89902672
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88584749
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86755875
74TAF2_19829295_ChIP-Seq_ESCs_Human0.86632520
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.86047050
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85755047
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85594558
78TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83954666
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83564829
80P300_19829295_ChIP-Seq_ESCs_Human0.82643222
81FUS_26573619_Chip-Seq_HEK293_Human0.82616993
82ER_23166858_ChIP-Seq_MCF-7_Human0.81228764
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.81059693
84KLF4_19829295_ChIP-Seq_ESCs_Human0.80501904
85P53_21459846_ChIP-Seq_SAOS-2_Human0.80024418
86NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79455058
87ERA_21632823_ChIP-Seq_H3396_Human0.78914023
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78208657
89RARB_27405468_Chip-Seq_BRAIN_Mouse0.78012410
90RUNX2_22187159_ChIP-Seq_PCA_Human0.77295698
91HTT_18923047_ChIP-ChIP_STHdh_Human0.76871559
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.75571124
93MYC_27129775_Chip-Seq_CORNEA_Mouse0.75262979
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.74623152
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.74622614
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.74432336
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.73937707
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73257100
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72082713
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72036602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.15237560
2MP0006292_abnormal_olfactory_placode3.65624964
3MP0003787_abnormal_imprinting3.61028395
4MP0006276_abnormal_autonomic_nervous3.58563758
5MP0005423_abnormal_somatic_nervous3.27691585
6MP0008877_abnormal_DNA_methylation2.92597927
7MP0003011_delayed_dark_adaptation2.82111401
8MP0004859_abnormal_synaptic_plasticity2.62526825
9MP0003122_maternal_imprinting2.61684070
10MP0009379_abnormal_foot_pigmentation2.60884920
11MP0002638_abnormal_pupillary_reflex2.50378475
12MP0000778_abnormal_nervous_system2.20871685
13MP0003121_genomic_imprinting2.06012883
14MP0004142_abnormal_muscle_tone1.99138665
15MP0003123_paternal_imprinting1.97579117
16MP0003646_muscle_fatigue1.89562558
17MP0000955_abnormal_spinal_cord1.89310651
18MP0009780_abnormal_chondrocyte_physiolo1.84073504
19MP0002653_abnormal_ependyma_morphology1.83795923
20MP0002163_abnormal_gland_morphology1.76645487
21MP0002876_abnormal_thyroid_physiology1.74297406
22MP0002822_catalepsy1.73940157
23MP0003329_amyloid_beta_deposits1.66598830
24MP0002272_abnormal_nervous_system1.65010042
25MP0002102_abnormal_ear_morphology1.62337690
26MP0001970_abnormal_pain_threshold1.56054948
27MP0004270_analgesia1.54439584
28MP0003635_abnormal_synaptic_transmissio1.52263347
29MP0008995_early_reproductive_senescence1.44028218
30MP0001986_abnormal_taste_sensitivity1.43799463
31MP0000049_abnormal_middle_ear1.40878673
32MP0009745_abnormal_behavioral_response1.39761553
33MP0002063_abnormal_learning/memory/cond1.39397668
34MP0002733_abnormal_thermal_nociception1.38651324
35MP0005551_abnormal_eye_electrophysiolog1.38576505
36MP0002837_dystrophic_cardiac_calcinosis1.37823177
37MP0002909_abnormal_adrenal_gland1.34827673
38MP0002184_abnormal_innervation1.31446925
39MP0005645_abnormal_hypothalamus_physiol1.29886691
40MP0002557_abnormal_social/conspecific_i1.26223466
41MP0001529_abnormal_vocalization1.25258682
42MP0002734_abnormal_mechanical_nocicepti1.24757873
43MP0002752_abnormal_somatic_nervous1.20830434
44MP0003942_abnormal_urinary_system1.19246918
45MP0003755_abnormal_palate_morphology1.15401861
46MP0001968_abnormal_touch/_nociception1.14929382
47MP0002882_abnormal_neuron_morphology1.14170568
48MP0002064_seizures1.13952579
49MP0008789_abnormal_olfactory_epithelium1.12624875
50MP0003136_yellow_coat_color1.09265553
51MP0004133_heterotaxia1.07628301
52MP0002572_abnormal_emotion/affect_behav1.07497853
53MP0001905_abnormal_dopamine_level1.07214434
54MP0006072_abnormal_retinal_apoptosis1.06583549
55MP0004885_abnormal_endolymph1.06270425
56MP0000631_abnormal_neuroendocrine_gland1.03958018
57MP0001486_abnormal_startle_reflex1.03548498
58MP0002152_abnormal_brain_morphology1.03048305
59MP0002735_abnormal_chemical_nociception1.01957196
60MP0005646_abnormal_pituitary_gland0.99402235
61MP0008569_lethality_at_weaning0.96537657
62MP0002067_abnormal_sensory_capabilities0.96233972
63MP0005253_abnormal_eye_physiology0.96181051
64MP0003938_abnormal_ear_development0.95289581
65MP0002229_neurodegeneration0.95091340
66MP0004145_abnormal_muscle_electrophysio0.95046881
67MP0002249_abnormal_larynx_morphology0.94685344
68MP0004742_abnormal_vestibular_system0.94181228
69MP0005379_endocrine/exocrine_gland_phen0.93485562
70MP0005195_abnormal_posterior_eye0.92556210
71MP0000026_abnormal_inner_ear0.92088852
72MP0004130_abnormal_muscle_cell0.91375407
73MP0003786_premature_aging0.91047696
74MP0005499_abnormal_olfactory_system0.89030435
75MP0005394_taste/olfaction_phenotype0.89030435
76MP0003183_abnormal_peptide_metabolism0.87581089
77MP0002139_abnormal_hepatobiliary_system0.87436731
78MP0002938_white_spotting0.85794600
79MP0009046_muscle_twitch0.84553666
80MP0000569_abnormal_digit_pigmentation0.82966128
81MP0005083_abnormal_biliary_tract0.80746408
82MP0008775_abnormal_heart_ventricle0.79436986
83MP0001963_abnormal_hearing_physiology0.78536900
84MP0005389_reproductive_system_phenotype0.77674073
85MP0001485_abnormal_pinna_reflex0.75585665
86MP0001324_abnormal_eye_pigmentation0.75116770
87MP0005503_abnormal_tendon_morphology0.74516009
88MP0004811_abnormal_neuron_physiology0.73471744
89MP0005084_abnormal_gallbladder_morpholo0.73313725
90MP0000534_abnormal_ureter_morphology0.73277557
91MP0001440_abnormal_grooming_behavior0.73241151
92MP0002066_abnormal_motor_capabilities/c0.72971486
93MP0002116_abnormal_craniofacial_bone0.72278374
94MP0004147_increased_porphyrin_level0.71993061
95MP0004924_abnormal_behavior0.71389086
96MP0005386_behavior/neurological_phenoty0.71389086
97MP0001919_abnormal_reproductive_system0.70567194
98MP0002736_abnormal_nociception_after0.70352052
99MP0000604_amyloidosis0.69588582
100MP0003948_abnormal_gas_homeostasis0.67379686

Predicted human phenotypes

RankGene SetZ-score
1Thoracolumbar scoliosis (HP:0002944)5.75364990
2Supranuclear gaze palsy (HP:0000605)4.39318068
3Myokymia (HP:0002411)4.24774002
4Reticulocytopenia (HP:0001896)4.15399428
5Acute necrotizing encephalopathy (HP:0006965)3.81664529
6Hyperthyroidism (HP:0000836)3.76609555
7Abnormal mitochondria in muscle tissue (HP:0008316)3.54358893
8Pancreatic fibrosis (HP:0100732)3.42720270
9Hepatocellular necrosis (HP:0001404)3.31081802
10Pancreatic cysts (HP:0001737)3.22590624
11Acute encephalopathy (HP:0006846)3.18804410
12Papilledema (HP:0001085)3.13599294
13Agitation (HP:0000713)3.11138787
14Progressive macrocephaly (HP:0004481)3.10506734
15Mitochondrial inheritance (HP:0001427)3.02755527
16Hyperphosphatemia (HP:0002905)2.91646529
17Hepatic necrosis (HP:0002605)2.91482691
18Progressive cerebellar ataxia (HP:0002073)2.90342992
19Hyperglycinemia (HP:0002154)2.87007436
20Neonatal respiratory distress (HP:0002643)2.84299757
21Septo-optic dysplasia (HP:0100842)2.83767325
22Nephronophthisis (HP:0000090)2.74727631
23Rib fusion (HP:0000902)2.67719607
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67463860
25Increased CSF lactate (HP:0002490)2.67165566
26Abnormality of cells of the erythroid lineage (HP:0012130)2.66452900
27Hepatoblastoma (HP:0002884)2.65802339
28Abnormality of midbrain morphology (HP:0002418)2.62882203
29Molar tooth sign on MRI (HP:0002419)2.62882203
30Tubular atrophy (HP:0000092)2.58154755
31Polyphagia (HP:0002591)2.55184534
32Focal seizures (HP:0007359)2.50751510
33Adrenal hypoplasia (HP:0000835)2.50300514
34Abnormality of the renal medulla (HP:0100957)2.46934442
35Abnormality of DNA repair (HP:0003254)2.46728245
36Optic disc pallor (HP:0000543)2.41840179
37Long clavicles (HP:0000890)2.40493463
38Cystic liver disease (HP:0006706)2.39555040
39True hermaphroditism (HP:0010459)2.37230376
40Congenital stationary night blindness (HP:0007642)2.36849445
41Cerebral edema (HP:0002181)2.34810481
42Abnormal biliary tract physiology (HP:0012439)2.32745574
43Bile duct proliferation (HP:0001408)2.32745574
44Medial flaring of the eyebrow (HP:0010747)2.31111943
45Optic nerve coloboma (HP:0000588)2.26453923
46Abnormality of macular pigmentation (HP:0008002)2.25960600
47Focal motor seizures (HP:0011153)2.25113331
48Short femoral neck (HP:0100864)2.23070175
49Absent thumb (HP:0009777)2.20823315
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19047462
51Sclerocornea (HP:0000647)2.17986280
52Restlessness (HP:0000711)2.15571568
53Narrow forehead (HP:0000341)2.14569702
54Lissencephaly (HP:0001339)2.12853307
55Anencephaly (HP:0002323)2.12083733
56Abnormal pancreas size (HP:0012094)2.11505523
57Hypsarrhythmia (HP:0002521)2.10692591
58Postaxial foot polydactyly (HP:0001830)2.08473495
59Small hand (HP:0200055)2.07960018
60Pachygyria (HP:0001302)2.07750491
61Supernumerary spleens (HP:0009799)2.07576847
62EEG with generalized epileptiform discharges (HP:0011198)2.02934286
63Increased serum pyruvate (HP:0003542)2.02548114
64Asplenia (HP:0001746)1.99141727
65Abnormality of the renal cortex (HP:0011035)1.98973109
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.98752749
67Oligodactyly (hands) (HP:0001180)1.97700235
68Epileptiform EEG discharges (HP:0011182)1.97156389
69Broad alveolar ridges (HP:0000187)1.95534878
70Abnormal eating behavior (HP:0100738)1.94019368
71Abnormal respiratory motile cilium morphology (HP:0005938)1.91648454
72Abnormal respiratory epithelium morphology (HP:0012253)1.91648454
73Holoprosencephaly (HP:0001360)1.90866047
74Hypoplastic pelvis (HP:0008839)1.90031896
75Chronic hepatic failure (HP:0100626)1.88794253
76Abnormal drinking behavior (HP:0030082)1.88402332
77Polydipsia (HP:0001959)1.88402332
78Tachypnea (HP:0002789)1.87631910
79Hypoplasia of the ulna (HP:0003022)1.86839731
80Gait imbalance (HP:0002141)1.85690502
81Growth hormone deficiency (HP:0000824)1.84624446
82Abolished electroretinogram (ERG) (HP:0000550)1.84145251
83Drooling (HP:0002307)1.81941625
84Pendular nystagmus (HP:0012043)1.79651871
85Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.79335266
86Optic nerve hypoplasia (HP:0000609)1.78913942
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75562277
88Facial shape deformation (HP:0011334)1.75275819
89Potter facies (HP:0002009)1.75275819
90High anterior hairline (HP:0009890)1.74113564
91Impulsivity (HP:0100710)1.73432685
92Abnormality of the metopic suture (HP:0005556)1.72660275
93Hypoparathyroidism (HP:0000829)1.71521546
94Highly arched eyebrow (HP:0002553)1.71326710
95Hyperventilation (HP:0002883)1.70810296
96Synostosis of carpal bones (HP:0005048)1.69183689
973-Methylglutaconic aciduria (HP:0003535)1.68726929
98Macrocytic anemia (HP:0001972)1.68610328
99Broad-based gait (HP:0002136)1.67046850
100Irregular vertebral endplates (HP:0003301)1.66774985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.17795134
2STK393.78763168
3PIK3CA3.37532979
4NME12.85508343
5MAP4K22.72783831
6EPHB22.43507626
7MARK12.29589874
8BCKDK2.28534770
9STK162.08622828
10TYRO31.97989191
11ICK1.97947149
12NTRK21.90398569
13FRK1.89282785
14MARK21.88995394
15TAOK31.87360884
16MINK11.79828183
17CDK191.73108253
18NEK11.66679612
19DYRK21.65377480
20MAP3K41.46801322
21ADRBK21.45573044
22MAP3K91.41364773
23GRK11.40651640
24MAP2K71.37999997
25MAP3K71.32413603
26BMPR1B1.31989372
27PHKG21.29119838
28PHKG11.29119838
29PNCK1.28854788
30CAMK1D1.27409062
31ARAF1.27046378
32WNK11.23053592
33CASK1.21098930
34LRRK21.17241747
35CAMK1G1.15663358
36AURKA1.08958862
37MAPK121.08739114
38PRKCG1.07512054
39DYRK1B1.03987239
40MAPK131.00697282
41CDC42BPA0.96059583
42PDK20.92013952
43PAK30.90757426
44ADRBK10.89338432
45OXSR10.85675135
46PRKCQ0.85187639
47BRAF0.84878546
48CAMK2D0.81461929
49WNK30.80872947
50PRKD20.80777945
51BRSK10.76652958
52STK110.74936117
53PRKCI0.74720521
54CDK50.73123068
55PIM20.72919833
56MAPK110.71378200
57CAMK10.70602914
58CAMKK20.70010523
59ABL20.68668084
60PRKACA0.68221172
61NTRK30.68075788
62INSRR0.65935060
63PRKAA10.65637460
64MAP2K40.63929933
65UHMK10.63043687
66CAMK2A0.61997564
67CDK140.61048098
68MKNK20.60168103
69CSNK1E0.59024791
70BCR0.57612315
71CAMK2B0.57005190
72TIE10.55765094
73AURKB0.54845794
74CDK150.54496595
75STK38L0.53697096
76RPS6KA30.52414538
77PLK10.52079141
78PAK60.50180700
79CDK180.49944134
80PRKCZ0.47640787
81TAOK10.47507073
82CDK11A0.47371919
83DDR20.47024740
84PKN10.42039773
85CDK30.41832840
86AKT10.41736066
87PRKCA0.40299626
88CSNK1G20.39133128
89PINK10.38816522
90PRKCE0.38448512
91CAMK2G0.37897769
92RPS6KA60.37878681
93SGK4940.37660326
94SGK2230.37660326
95DAPK30.35827955
96CSNK1G30.35031979
97MAPK140.34902631
98CSNK2A10.34819311
99CSNK2A20.32875257
100SYK0.32763629

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.45782146
2Cardiac muscle contraction_Homo sapiens_hsa042604.07345784
3Oxidative phosphorylation_Homo sapiens_hsa001903.75343848
4Ribosome_Homo sapiens_hsa030103.53007413
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.38823909
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.31470370
7Parkinsons disease_Homo sapiens_hsa050123.29037173
8Steroid biosynthesis_Homo sapiens_hsa001002.79427275
9Alzheimers disease_Homo sapiens_hsa050102.45161511
10Huntingtons disease_Homo sapiens_hsa050162.13456322
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11035513
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06108620
13Peroxisome_Homo sapiens_hsa041462.04861931
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75288857
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.71196100
16Butanoate metabolism_Homo sapiens_hsa006501.69823543
17Propanoate metabolism_Homo sapiens_hsa006401.45794741
18Nicotine addiction_Homo sapiens_hsa050331.44245687
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44178695
20Axon guidance_Homo sapiens_hsa043601.41266745
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28563149
22Dilated cardiomyopathy_Homo sapiens_hsa054141.26143876
23Insulin secretion_Homo sapiens_hsa049111.22855411
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21548610
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21233140
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20182405
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18666155
28Tryptophan metabolism_Homo sapiens_hsa003801.18292621
29Sulfur relay system_Homo sapiens_hsa041221.13988080
30Phototransduction_Homo sapiens_hsa047441.03831901
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03123589
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01200175
33Arginine and proline metabolism_Homo sapiens_hsa003301.01091785
34Hedgehog signaling pathway_Homo sapiens_hsa043401.00584241
35Cocaine addiction_Homo sapiens_hsa050300.98594277
36beta-Alanine metabolism_Homo sapiens_hsa004100.96664163
37Homologous recombination_Homo sapiens_hsa034400.93744007
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93186447
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.90277420
40Nitrogen metabolism_Homo sapiens_hsa009100.90043309
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87648765
42Cholinergic synapse_Homo sapiens_hsa047250.86875985
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82306614
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81724747
45Pyruvate metabolism_Homo sapiens_hsa006200.81221602
46Protein export_Homo sapiens_hsa030600.79506418
47GABAergic synapse_Homo sapiens_hsa047270.78061312
48Retinol metabolism_Homo sapiens_hsa008300.77670513
49Circadian entrainment_Homo sapiens_hsa047130.76979016
50Olfactory transduction_Homo sapiens_hsa047400.74411939
51Morphine addiction_Homo sapiens_hsa050320.73558712
52Oxytocin signaling pathway_Homo sapiens_hsa049210.73210711
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72607136
54Taste transduction_Homo sapiens_hsa047420.72035770
55Glutamatergic synapse_Homo sapiens_hsa047240.70978798
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69446942
57Serotonergic synapse_Homo sapiens_hsa047260.69436347
58Fat digestion and absorption_Homo sapiens_hsa049750.67157304
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.65784197
60Notch signaling pathway_Homo sapiens_hsa043300.65611276
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65568993
62Nucleotide excision repair_Homo sapiens_hsa034200.65219151
63Basal cell carcinoma_Homo sapiens_hsa052170.64436012
64Metabolic pathways_Homo sapiens_hsa011000.62196828
65MAPK signaling pathway_Homo sapiens_hsa040100.62052814
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61941540
67Dopaminergic synapse_Homo sapiens_hsa047280.61835155
68Fatty acid degradation_Homo sapiens_hsa000710.61749209
69Chemical carcinogenesis_Homo sapiens_hsa052040.61655097
70PPAR signaling pathway_Homo sapiens_hsa033200.59004140
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.57402379
72Renin secretion_Homo sapiens_hsa049240.56603376
73Salivary secretion_Homo sapiens_hsa049700.55579954
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51776802
75Fatty acid metabolism_Homo sapiens_hsa012120.51369597
76Gastric acid secretion_Homo sapiens_hsa049710.51350673
77Linoleic acid metabolism_Homo sapiens_hsa005910.50773165
78Basal transcription factors_Homo sapiens_hsa030220.50288104
79Collecting duct acid secretion_Homo sapiens_hsa049660.49866288
80Synaptic vesicle cycle_Homo sapiens_hsa047210.49187235
81RNA degradation_Homo sapiens_hsa030180.47466177
82Non-homologous end-joining_Homo sapiens_hsa034500.47274297
83Amphetamine addiction_Homo sapiens_hsa050310.46428870
84Fanconi anemia pathway_Homo sapiens_hsa034600.46135126
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45961575
86Gap junction_Homo sapiens_hsa045400.44414517
87Ether lipid metabolism_Homo sapiens_hsa005650.42852870
88RNA polymerase_Homo sapiens_hsa030200.39695414
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38377760
90Long-term depression_Homo sapiens_hsa047300.37767493
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37676594
92Ras signaling pathway_Homo sapiens_hsa040140.37126320
93Dorso-ventral axis formation_Homo sapiens_hsa043200.36174006
94Hippo signaling pathway_Homo sapiens_hsa043900.36168255
95Glycerolipid metabolism_Homo sapiens_hsa005610.35912376
96Fatty acid elongation_Homo sapiens_hsa000620.34740593
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34075175
98Bile secretion_Homo sapiens_hsa049760.30816111
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29171329
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27461149

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