GNG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)6.22801732
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.93580053
3synaptic transmission, dopaminergic (GO:0001963)5.85610951
4prepulse inhibition (GO:0060134)5.78465470
5locomotory exploration behavior (GO:0035641)5.72426288
6synaptic vesicle maturation (GO:0016188)5.59089259
7axon ensheathment in central nervous system (GO:0032291)5.43630953
8central nervous system myelination (GO:0022010)5.43630953
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39056826
10cellular potassium ion homeostasis (GO:0030007)5.38299240
11adenosine receptor signaling pathway (GO:0001973)5.29146260
12L-amino acid import (GO:0043092)5.20427275
13regulation of long-term neuronal synaptic plasticity (GO:0048169)5.14779135
14striatum development (GO:0021756)4.99995340
15adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.99130178
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98928630
17vocalization behavior (GO:0071625)4.95560948
18sodium ion export (GO:0071436)4.91878405
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89297286
20regulation of glutamate receptor signaling pathway (GO:1900449)4.83208718
21regulation of neuronal synaptic plasticity (GO:0048168)4.82306173
22auditory behavior (GO:0031223)4.80833691
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.76465527
24postsynaptic membrane organization (GO:0001941)4.69145538
25neurotransmitter-gated ion channel clustering (GO:0072578)4.57499888
26positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.56772546
27response to amphetamine (GO:0001975)4.56495406
28regulation of dendritic spine morphogenesis (GO:0061001)4.53211588
29dopamine receptor signaling pathway (GO:0007212)4.50517037
30positive regulation of synaptic transmission, GABAergic (GO:0032230)4.49961964
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.45475899
32negative regulation of cytosolic calcium ion concentration (GO:0051481)4.44583378
33negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.42165122
34synaptic vesicle exocytosis (GO:0016079)4.35821907
35dendritic spine morphogenesis (GO:0060997)4.31672549
36neuromuscular process controlling balance (GO:0050885)4.29232829
37ionotropic glutamate receptor signaling pathway (GO:0035235)4.26751348
38amino acid import (GO:0043090)4.26038557
39potassium ion import (GO:0010107)4.24179950
40negative regulation of synaptic transmission, GABAergic (GO:0032229)4.23962014
41behavioral response to cocaine (GO:0048148)4.23830048
42neurotransmitter transport (GO:0006836)4.22637147
43positive regulation of neurotransmitter transport (GO:0051590)4.22201547
44positive regulation of synapse maturation (GO:0090129)4.21814407
45cAMP catabolic process (GO:0006198)4.20670703
46synaptic vesicle docking involved in exocytosis (GO:0016081)4.19629449
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.16994902
48response to auditory stimulus (GO:0010996)4.16808162
49regulation of synaptic vesicle exocytosis (GO:2000300)4.13393873
50neuron-neuron synaptic transmission (GO:0007270)4.10660174
51regulation of female receptivity (GO:0045924)4.10332958
52exploration behavior (GO:0035640)4.06995781
53potassium ion homeostasis (GO:0055075)4.06509553
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06385826
55cerebellar granule cell differentiation (GO:0021707)4.06120812
56protein localization to synapse (GO:0035418)4.05275898
57substrate-independent telencephalic tangential migration (GO:0021826)4.04822374
58substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.04822374
59long-term memory (GO:0007616)4.02957232
60regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01001634
61neurotransmitter secretion (GO:0007269)3.98493808
62positive regulation of membrane potential (GO:0045838)3.93985439
63regulation of glutamate secretion (GO:0014048)3.92933365
64synaptic transmission, glutamatergic (GO:0035249)3.90295959
65regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.90229548
66regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.90229548
67neuronal ion channel clustering (GO:0045161)3.90026705
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.89356659
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.89181767
70regulation of neurotransmitter levels (GO:0001505)3.88570015
71transmission of nerve impulse (GO:0019226)3.86812175
72neuronal action potential propagation (GO:0019227)3.85990646
73layer formation in cerebral cortex (GO:0021819)3.80582812
74cyclic nucleotide catabolic process (GO:0009214)3.77227208
75regulation of neurotransmitter secretion (GO:0046928)3.76509818
76positive regulation of neurotransmitter secretion (GO:0001956)3.73891986
77regulation of synaptic plasticity (GO:0048167)3.71790390
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71621045
79regulation of synaptic vesicle transport (GO:1902803)3.70980068
80gamma-aminobutyric acid transport (GO:0015812)3.70294992
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.70290465
82regulation of neurotransmitter uptake (GO:0051580)3.66947446
83regulation of postsynaptic membrane potential (GO:0060078)3.66690199
84regulation of ARF protein signal transduction (GO:0032012)3.64883985
85neurotransmitter uptake (GO:0001504)3.63523829
86regulation of synapse maturation (GO:0090128)3.60499922
87visual learning (GO:0008542)3.60107939
88female mating behavior (GO:0060180)3.59472449
89glutamate secretion (GO:0014047)3.57957059
90glutamate receptor signaling pathway (GO:0007215)3.57815797
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54440904
92glycine transport (GO:0015816)3.53669780
93activation of protein kinase A activity (GO:0034199)3.53584258
94mechanosensory behavior (GO:0007638)3.53057859
95cAMP metabolic process (GO:0046058)3.48741122
96regulation of dendritic spine development (GO:0060998)3.47237447
97peristalsis (GO:0030432)3.47113357
98phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.45768474
99membrane hyperpolarization (GO:0060081)3.42501596
100long-term synaptic potentiation (GO:0060291)3.40979367
101visual behavior (GO:0007632)3.38175017
102regulation of voltage-gated calcium channel activity (GO:1901385)3.36590773
103positive regulation of Rap GTPase activity (GO:0032854)3.34626870
104negative regulation of dendrite development (GO:2000171)3.32974662
105presynaptic membrane organization (GO:0097090)3.32874878
106cerebellar Purkinje cell differentiation (GO:0021702)3.32129819
107regulation of synaptic transmission, GABAergic (GO:0032228)3.31577169
108response to histamine (GO:0034776)3.31519111
109cellular sodium ion homeostasis (GO:0006883)3.30733894
110cell communication by electrical coupling (GO:0010644)3.28927243
111regulation of protein kinase A signaling (GO:0010738)3.28458371
112membrane depolarization during action potential (GO:0086010)3.26917174
113acidic amino acid transport (GO:0015800)3.25226968
114learning (GO:0007612)3.24550025
115detection of calcium ion (GO:0005513)3.20850458
116mating behavior (GO:0007617)3.18701747
117neuron cell-cell adhesion (GO:0007158)3.18185182
118neuromuscular process (GO:0050905)3.16503476
119dendritic spine organization (GO:0097061)3.16002191
120regulation of norepinephrine secretion (GO:0014061)3.14591389
121positive regulation of synaptic transmission (GO:0050806)3.14400441
122response to amine (GO:0014075)3.14262695
123membrane depolarization (GO:0051899)3.14023532
124presynaptic membrane assembly (GO:0097105)3.13850817
125negative regulation of amino acid transport (GO:0051956)3.13358107
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11881636
127primary amino compound metabolic process (GO:1901160)3.11231254
128positive regulation of dendritic spine development (GO:0060999)3.11013583
129regulation of neurotransmitter transport (GO:0051588)3.10119516
130proline transport (GO:0015824)3.10066004
131cAMP biosynthetic process (GO:0006171)3.09189814
132regulation of Rap GTPase activity (GO:0032317)3.08588155
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07700254
134* synaptic transmission (GO:0007268)3.06725746
135regulation of synaptic transmission (GO:0050804)3.06446498
136synaptic vesicle endocytosis (GO:0048488)3.04430895
137regulation of vesicle fusion (GO:0031338)3.04033998
138neuromuscular process controlling posture (GO:0050884)3.02039800
139regulation of exocytosis (GO:0017157)2.98964603
140potassium ion transmembrane transport (GO:0071805)2.98701387
141cellular potassium ion transport (GO:0071804)2.98701387
142neuromuscular synaptic transmission (GO:0007274)2.97852247
143negative regulation of dendrite morphogenesis (GO:0050774)2.88322444
144L-glutamate transport (GO:0015813)2.85982753
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81366907
146C4-dicarboxylate transport (GO:0015740)2.80595287
147serotonin metabolic process (GO:0042428)2.80299586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02886104
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.04220873
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18295277
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16058164
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02136707
6GBX2_23144817_ChIP-Seq_PC3_Human2.97613863
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90034081
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80323871
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80323871
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78256296
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.72234424
12REST_21632747_ChIP-Seq_MESCs_Mouse2.71418585
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64883798
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64620020
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63790319
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61902450
17* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60996726
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.50026403
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42163679
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38115640
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.36049646
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30523878
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29288536
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.29062226
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.23813236
26AR_21572438_ChIP-Seq_LNCaP_Human2.16157819
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.02924807
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.99103004
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94486333
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77716532
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64232814
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61062355
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47809096
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44028683
35* KDM2B_26808549_Chip-Seq_K562_Human1.41470731
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40191238
37* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37187676
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37133204
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34271801
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33464431
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32903474
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31499950
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30651332
44SMAD4_21799915_ChIP-Seq_A2780_Human1.29535762
45* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29189534
46P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28940995
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28914153
48LXR_22292898_ChIP-Seq_THP-1_Human1.28642018
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28371018
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25611640
51* OCT4_19829295_ChIP-Seq_ESCs_Human1.25085178
52TAF15_26573619_Chip-Seq_HEK293_Human1.21747121
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.21662994
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.20855738
55* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17826940
56* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17669109
57* AR_19668381_ChIP-Seq_PC3_Human1.16903896
58* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16318147
59CTCF_27219007_Chip-Seq_Bcells_Human1.11775654
60P68_20966046_ChIP-Seq_HELA_Human1.11065337
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09743432
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.09663895
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08843654
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08413042
65* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08364913
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08090142
67* STAT3_23295773_ChIP-Seq_U87_Human1.08087606
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07540181
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06062130
70* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04598018
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04343414
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03701076
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01857224
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99922286
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98134109
76GATA1_26923725_Chip-Seq_HPCs_Mouse0.97120431
77TET1_21490601_ChIP-Seq_MESCs_Mouse0.96565519
78AHR_22903824_ChIP-Seq_MCF-7_Human0.95482360
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95402006
80* KLF4_19829295_ChIP-Seq_ESCs_Human0.95164664
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94930279
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94301183
83TCF4_23295773_ChIP-Seq_U87_Human0.93671283
84RXR_22108803_ChIP-Seq_LS180_Human0.93631768
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.93377153
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92780906
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.92038323
88* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91873766
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91864394
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91771130
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91606409
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91558228
93P300_19829295_ChIP-Seq_ESCs_Human0.91369114
94* SMC4_20622854_ChIP-Seq_HELA_Human0.90933977
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90821880
96SMAD4_21741376_ChIP-Seq_ESCs_Human0.90643048
97AR_25329375_ChIP-Seq_VCAP_Human0.90242386
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90166617
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90084954
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88840359
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88624014
102RNF2_27304074_Chip-Seq_NSC_Mouse0.87755066
103* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87068295
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.86771684
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.86662144
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.86381099
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85345652
108RUNX2_22187159_ChIP-Seq_PCA_Human0.84250937
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.82598474
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.82223991
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82096468
112KDM2B_26808549_Chip-Seq_DND41_Human0.81047026
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80954565
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80954565
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80915282
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80613635
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.80260740
118SMAD4_21741376_ChIP-Seq_EPCs_Human0.79718340
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78448894
120CTCF_20526341_ChIP-Seq_ESCs_Human0.77802863
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77709234
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76803822
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76257472
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76195699
125EGR1_19032775_ChIP-ChIP_M12_Human0.75240250
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.74597104
127SA1_27219007_Chip-Seq_Bcells_Human0.71486710
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.70872321
129SCL_19346495_ChIP-Seq_HPC-7_Human0.70565945
130OCT4_20526341_ChIP-Seq_ESCs_Human0.69534031
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.69079358
132* BCOR_27268052_Chip-Seq_Bcells_Human0.68494737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.69051704
2MP0004859_abnormal_synaptic_plasticity6.66577040
3MP0003635_abnormal_synaptic_transmissio4.14831552
4MP0003880_abnormal_central_pattern4.10926465
5MP0009745_abnormal_behavioral_response3.71513009
6MP0002063_abnormal_learning/memory/cond3.50542558
7MP0004270_analgesia3.42375399
8MP0002064_seizures3.04842377
9MP0002572_abnormal_emotion/affect_behav2.79386416
10MP0001529_abnormal_vocalization2.74441300
11MP0009046_muscle_twitch2.73806570
12* MP0001486_abnormal_startle_reflex2.55745887
13MP0002272_abnormal_nervous_system2.52356795
14MP0005423_abnormal_somatic_nervous2.49793791
15MP0001968_abnormal_touch/_nociception2.40678370
16MP0002909_abnormal_adrenal_gland2.35258835
17MP0005646_abnormal_pituitary_gland2.15081053
18MP0002734_abnormal_mechanical_nocicepti2.12025876
19MP0001501_abnormal_sleep_pattern2.00702861
20MP0004924_abnormal_behavior1.93552916
21MP0005386_behavior/neurological_phenoty1.93552916
22MP0005409_darkened_coat_color1.88944506
23MP0001970_abnormal_pain_threshold1.79681990
24MP0008569_lethality_at_weaning1.75399434
25MP0002733_abnormal_thermal_nociception1.74019442
26MP0004811_abnormal_neuron_physiology1.73289367
27MP0009780_abnormal_chondrocyte_physiolo1.71482453
28MP0002557_abnormal_social/conspecific_i1.67603734
29MP0001986_abnormal_taste_sensitivity1.61588588
30MP0001440_abnormal_grooming_behavior1.58042590
31MP0002736_abnormal_nociception_after1.54755773
32MP0004885_abnormal_endolymph1.54511585
33MP0001984_abnormal_olfaction1.52612025
34MP0001188_hyperpigmentation1.50739756
35MP0003075_altered_response_to1.49778875
36MP0002067_abnormal_sensory_capabilities1.44809611
37MP0003329_amyloid_beta_deposits1.43723494
38MP0003879_abnormal_hair_cell1.35676367
39MP0001177_atelectasis1.32426414
40MP0002066_abnormal_motor_capabilities/c1.32156324
41MP0000955_abnormal_spinal_cord1.30944892
42MP0008874_decreased_physiological_sensi1.28595335
43MP0001905_abnormal_dopamine_level1.28585274
44MP0002735_abnormal_chemical_nociception1.28276621
45MP0002184_abnormal_innervation1.24861899
46MP0005167_abnormal_blood-brain_barrier1.24606433
47MP0008872_abnormal_physiological_respon1.21558772
48MP0000778_abnormal_nervous_system1.20508741
49MP0000013_abnormal_adipose_tissue1.19124756
50MP0002882_abnormal_neuron_morphology1.18299994
51MP0003690_abnormal_glial_cell1.17818202
52* MP0003633_abnormal_nervous_system1.17093781
53MP0000920_abnormal_myelination1.13452133
54MP0003183_abnormal_peptide_metabolism1.12906681
55MP0004858_abnormal_nervous_system1.10994345
56MP0004147_increased_porphyrin_level1.09167909
57MP0003283_abnormal_digestive_organ1.04068102
58MP0008877_abnormal_DNA_methylation1.03094051
59MP0008961_abnormal_basal_metabolism1.02315609
60MP0010234_abnormal_vibrissa_follicle1.01414250
61MP0004085_abnormal_heartbeat1.00469683
62MP0003122_maternal_imprinting0.98844602
63MP0002090_abnormal_vision0.97028933
64* MP0003631_nervous_system_phenotype0.95290090
65MP0002069_abnormal_eating/drinking_beha0.95274857
66MP0001502_abnormal_circadian_rhythm0.94166783
67MP0004142_abnormal_muscle_tone0.94133968
68MP0002152_abnormal_brain_morphology0.92925069
69MP0005535_abnormal_body_temperature0.89180729
70MP0003123_paternal_imprinting0.88703383
71MP0003787_abnormal_imprinting0.86712167
72MP0002638_abnormal_pupillary_reflex0.85933075
73MP0004130_abnormal_muscle_cell0.84885972
74MP0005670_abnormal_white_adipose0.82167529
75MP0005645_abnormal_hypothalamus_physiol0.81349824
76MP0003634_abnormal_glial_cell0.81121203
77MP0000569_abnormal_digit_pigmentation0.80443686
78MP0002229_neurodegeneration0.79788776
79MP0005499_abnormal_olfactory_system0.79707052
80MP0005394_taste/olfaction_phenotype0.79707052
81MP0000751_myopathy0.75818502
82MP0003137_abnormal_impulse_conducting0.71528969
83MP0001348_abnormal_lacrimal_gland0.69832547
84MP0000631_abnormal_neuroendocrine_gland0.68204513
85MP0005171_absent_coat_pigmentation0.67142494
86MP0003045_fibrosis0.66532794
87MP0002653_abnormal_ependyma_morphology0.66478376
88MP0000604_amyloidosis0.64121141
89MP0000026_abnormal_inner_ear0.63525681
90MP0003632_abnormal_nervous_system0.63405629
91MP0004043_abnormal_pH_regulation0.62087038
92MP0001485_abnormal_pinna_reflex0.61030497
93MP0005166_decreased_susceptibility_to0.57355642
94MP0001664_abnormal_digestion0.57303617
95MP0005551_abnormal_eye_electrophysiolog0.56336972
96MP0006276_abnormal_autonomic_nervous0.55913378
97MP0004742_abnormal_vestibular_system0.55068703
98MP0002876_abnormal_thyroid_physiology0.52438984
99MP0004510_myositis0.51514275
100MP0005253_abnormal_eye_physiology0.51008549
101MP0000639_abnormal_adrenal_gland0.50795923
102MP0000003_abnormal_adipose_tissue0.49072385
103MP0002083_premature_death0.49044701
104MP0004215_abnormal_myocardial_fiber0.48585549
105MP0001943_abnormal_respiration0.47905859
106MP0004484_altered_response_of0.46644564
107MP0005671_abnormal_response_to0.46550850
108MP0001765_abnormal_ion_homeostasis0.46091479
109MP0002752_abnormal_somatic_nervous0.46051615
110MP0003956_abnormal_body_size0.45102464
111MP0002873_normal_phenotype0.43645409
112MP0001963_abnormal_hearing_physiology0.42912244
113MP0003172_abnormal_lysosome_physiology0.42863707
114MP0001299_abnormal_eye_distance/0.41199973
115MP0010769_abnormal_survival0.40896053
116MP0005623_abnormal_meninges_morphology0.40483608
117MP0010770_preweaning_lethality0.38437070
118MP0002082_postnatal_lethality0.38437070
119MP0010768_mortality/aging0.37647529
120MP0004233_abnormal_muscle_weight0.37492088
121MP0005620_abnormal_muscle_contractility0.36951684
122MP0003303_peritoneal_inflammation0.35768646
123MP0000534_abnormal_ureter_morphology0.34403587
124MP0000230_abnormal_systemic_arterial0.34165738

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.62577816
2Focal motor seizures (HP:0011153)7.52507144
3Focal seizures (HP:0007359)5.58716205
4Abnormality of binocular vision (HP:0011514)4.91716236
5Diplopia (HP:0000651)4.91716236
6Torticollis (HP:0000473)4.51069749
7Annular pancreas (HP:0001734)4.41316480
8Resting tremor (HP:0002322)4.29735024
9Ankle clonus (HP:0011448)4.16707967
10Visual hallucinations (HP:0002367)4.13253662
11Action tremor (HP:0002345)4.08913256
12Poor eye contact (HP:0000817)4.07662017
13Cerebral hypomyelination (HP:0006808)3.90991803
14Focal dystonia (HP:0004373)3.88325637
15Anxiety (HP:0000739)3.84889559
16Craniofacial dystonia (HP:0012179)3.79196682
17Impaired vibration sensation in the lower limbs (HP:0002166)3.72515300
18Impaired social interactions (HP:0000735)3.69443106
19Abnormal social behavior (HP:0012433)3.69443106
20Depression (HP:0000716)3.65918586
21Epileptic encephalopathy (HP:0200134)3.59562887
22Broad-based gait (HP:0002136)3.56240162
23Ankyloglossia (HP:0010296)3.49637549
24Dysdiadochokinesis (HP:0002075)3.45805704
25Urinary bladder sphincter dysfunction (HP:0002839)3.39172749
26Generalized tonic-clonic seizures (HP:0002069)3.36904758
27Delusions (HP:0000746)3.26200840
28Papilledema (HP:0001085)3.25680699
29Urinary urgency (HP:0000012)3.18661244
30Dysmetria (HP:0001310)3.17718099
31Febrile seizures (HP:0002373)3.17547231
32Stereotypic behavior (HP:0000733)3.15434329
33Gaze-evoked nystagmus (HP:0000640)3.14192690
34Absence seizures (HP:0002121)3.11620890
35Scanning speech (HP:0002168)3.10464168
36Supranuclear gaze palsy (HP:0000605)3.09435590
37Peripheral hypomyelination (HP:0007182)3.09263576
38Postural instability (HP:0002172)3.08699803
39Pointed chin (HP:0000307)3.04589875
40Dialeptic seizures (HP:0011146)2.99804241
41Agammaglobulinemia (HP:0004432)2.93925543
42Lower limb amyotrophy (HP:0007210)2.92114530
43Spastic gait (HP:0002064)2.91482830
44Intention tremor (HP:0002080)2.88803889
45Atonic seizures (HP:0010819)2.85577306
46Progressive cerebellar ataxia (HP:0002073)2.82749659
47Megalencephaly (HP:0001355)2.81228350
48Prolonged QT interval (HP:0001657)2.79812653
49Abnormal eating behavior (HP:0100738)2.79698896
50Truncal ataxia (HP:0002078)2.78439118
51Polygenic inheritance (HP:0010982)2.75158829
52Dysmetric saccades (HP:0000641)2.71312213
53Increased circulating renin level (HP:0000848)2.66349217
54Abnormality of oral frenula (HP:0000190)2.61010322
55Limb dystonia (HP:0002451)2.59946235
56Tetraplegia (HP:0002445)2.56487115
57Abnormal EKG (HP:0003115)2.56122147
58Mutism (HP:0002300)2.54714257
59Impaired vibratory sensation (HP:0002495)2.53789359
60Atrioventricular block (HP:0001678)2.53506481
61Neurofibrillary tangles (HP:0002185)2.53070677
62Clonus (HP:0002169)2.52745540
63Impaired smooth pursuit (HP:0007772)2.52449874
64Bradykinesia (HP:0002067)2.47869162
65Abnormality of the lower motor neuron (HP:0002366)2.37752484
66Amblyopia (HP:0000646)2.30416545
67Lower limb muscle weakness (HP:0007340)2.29524806
68Cerebral inclusion bodies (HP:0100314)2.24906432
69Distal lower limb amyotrophy (HP:0008944)2.24043037
70Sleep apnea (HP:0010535)2.23600285
71Termporal pattern (HP:0011008)2.22818875
72Insidious onset (HP:0003587)2.22818875
73Ventricular fibrillation (HP:0001663)2.22818358
74Incomplete penetrance (HP:0003829)2.22815809
75Distal upper limb amyotrophy (HP:0007149)2.20981871
76Upper limb amyotrophy (HP:0009129)2.20981871
77Progressive inability to walk (HP:0002505)2.20550234
78Hemiparesis (HP:0001269)2.19900779
79Hyperventilation (HP:0002883)2.19443994
80CNS hypomyelination (HP:0003429)2.18446106
81Heart block (HP:0012722)2.17551628
82Obstructive sleep apnea (HP:0002870)2.15412735
83Memory impairment (HP:0002354)2.15097696
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13214383
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.13214383
86Choreoathetosis (HP:0001266)2.11834150
87Abnormality of ocular smooth pursuit (HP:0000617)2.11513120
88Axonal loss (HP:0003447)2.10656707
89Onion bulb formation (HP:0003383)2.10172667
90Neuronal loss in central nervous system (HP:0002529)2.09321919
91Bowel incontinence (HP:0002607)2.08999011
92Hemiplegia (HP:0002301)2.06140545
93Abnormality of the periventricular white matter (HP:0002518)2.03842033
94Polyphagia (HP:0002591)2.03418014
95Akinesia (HP:0002304)2.03213761
96Abnormality of saccadic eye movements (HP:0000570)2.02517332
97Truncus arteriosus (HP:0001660)2.01521389
98Status epilepticus (HP:0002133)2.01071058
99Lower limb asymmetry (HP:0100559)2.00151527
100Insomnia (HP:0100785)1.99891530
101Heterochromia iridis (HP:0001100)1.98122959
102Abnormal atrioventricular conduction (HP:0005150)1.96048991
103Apathy (HP:0000741)1.95880114
104Limb hypertonia (HP:0002509)1.94593586
105Genetic anticipation (HP:0003743)1.93163042
106Morphological abnormality of the inner ear (HP:0011390)1.92419312
107Rapidly progressive (HP:0003678)1.91997415
108Bundle branch block (HP:0011710)1.91850383
109Fetal akinesia sequence (HP:0001989)1.91696499
110Abnormality of the corticospinal tract (HP:0002492)1.91593089
111Excessive salivation (HP:0003781)1.91579908
112Drooling (HP:0002307)1.91579908
113Dysphonia (HP:0001618)1.91320106
114Ocular albinism (HP:0001107)1.90860364
115Abnormal large intestine physiology (HP:0012700)1.90352367
116Progressive microcephaly (HP:0000253)1.89726055
117Epileptiform EEG discharges (HP:0011182)1.88473515
118Rigidity (HP:0002063)1.88419589
119Diminished motivation (HP:0000745)1.88002945
120EEG with generalized epileptiform discharges (HP:0011198)1.87925632
121Hypsarrhythmia (HP:0002521)1.87219398
122Iris hypopigmentation (HP:0007730)1.86534221
123Absent speech (HP:0001344)1.86083554
124Spastic tetraparesis (HP:0001285)1.83371294
125Aplasia of the phalanges of the hand (HP:0009802)1.81196316
126Unsteady gait (HP:0002317)1.79049199
127Metabolic alkalosis (HP:0200114)1.77921439
128Morphological abnormality of the pyramidal tract (HP:0002062)1.76388710
129Spinal canal stenosis (HP:0003416)1.76316942
130Hypokalemic alkalosis (HP:0001949)1.72544704
131Dementia (HP:0000726)1.67240586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.74763186
2NTRK34.00177178
3MAP3K93.58331286
4KSR22.92771107
5DAPK22.75823003
6PRKD32.72766447
7CAMKK12.33830441
8RIPK42.30532667
9MINK12.16979349
10MARK12.10643646
11NTRK11.96107427
12ARAF1.90763283
13FES1.89613146
14NTRK21.89217876
15MAP3K131.85880332
16KSR11.79176711
17MAP3K41.77600954
18PAK61.76763760
19TAOK11.69391658
20CDK51.64179367
21MAP3K21.60203932
22TNIK1.57121721
23TYRO31.53813943
24DAPK11.45331763
25PRPF4B1.43563778
26ERN11.36298708
27CAMKK21.33567096
28SIK21.32011511
29PKN11.29257403
30RAF11.27139297
31MAP2K71.25843389
32MAPK121.24075321
33MAP4K11.19248764
34CASK1.18526774
35MAP3K111.17776542
36SGK2231.10764787
37SGK4941.10764787
38PINK11.05376624
39STK381.05163578
40PRKCH1.03483116
41MAP2K40.98224113
42MARK20.96573315
43UHMK10.96280365
44SYK0.91380945
45BMPR20.87675981
46CDK180.86854731
47CDK150.86785385
48PRKCG0.86671777
49SGK30.86094565
50STK110.86064474
51SGK20.84644473
52CDK140.83317635
53PDPK10.82610172
54NEK10.80593500
55SGK10.80559165
56ALK0.80290403
57CAMK2B0.79061366
58RET0.78425240
59MAP3K10.77981332
60CAMK2A0.76158084
61PDK10.75964314
62CDK11A0.75618124
63CAMK10.74682160
64NEK60.72784848
65PTK2B0.70598881
66MAPK130.69838520
67RIPK10.66380728
68IRAK20.65348961
69LMTK20.63636740
70MAP2K60.62671093
71GRK50.61010848
72MAP3K120.60148200
73MAP2K10.59752885
74TRIB30.59275276
75TNK20.59055340
76PHKG10.58724487
77PHKG20.58724487
78FYN0.57338472
79CDK190.55368124
80BRSK10.55094277
81PRKCZ0.54895131
82RPS6KA30.54721027
83ROCK20.53256269
84DAPK30.52588722
85PRKD20.52466440
86DMPK0.51965970
87FRK0.51755184
88FGFR20.50638172
89TAOK30.49280350
90CCNB10.49232915
91PRKCQ0.48806690
92MAPK100.48754414
93MAPK70.47279059
94CAMK40.46976917
95MAP2K20.46875351
96WNK10.46425631
97JAK20.43852871
98PRKCA0.43366037
99PRKD10.43129232
100MOS0.42899999
101PLK20.42701313
102CSNK1G20.41252560
103OXSR10.39627933
104MAP2K30.38968411
105CAMK2G0.38400687
106BLK0.38240088
107CAMK2D0.37891759
108PRKACA0.36868245
109PRKCE0.36705706
110BRAF0.36539069
111MAPK40.36026263
112ADRBK20.35805666
113PAK30.34822365
114KIT0.34769718
115DDR20.34627039
116SCYL20.34532692
117PRKCB0.33758792
118CDC42BPA0.32751720
119PRKG10.32421845
120PDGFRA0.32339189
121ROCK10.32214951
122DYRK1A0.31568199
123CSNK1A10.29775767
124MAP3K70.29235989
125PRKACG0.28449765
126BMX0.28365320
127FGR0.28286994

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047403.37441166
2Nicotine addiction_Homo sapiens_hsa050332.85721126
3* Morphine addiction_Homo sapiens_hsa050322.79003215
4Amphetamine addiction_Homo sapiens_hsa050312.77497996
5Cocaine addiction_Homo sapiens_hsa050302.73068385
6Synaptic vesicle cycle_Homo sapiens_hsa047212.70953863
7* Circadian entrainment_Homo sapiens_hsa047132.65403738
8* GABAergic synapse_Homo sapiens_hsa047272.63803447
9Long-term potentiation_Homo sapiens_hsa047202.63721680
10* Glutamatergic synapse_Homo sapiens_hsa047242.44238160
11* Dopaminergic synapse_Homo sapiens_hsa047282.32955355
12* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22535991
13* Cholinergic synapse_Homo sapiens_hsa047252.15977277
14Salivary secretion_Homo sapiens_hsa049702.08670397
15Nitrogen metabolism_Homo sapiens_hsa009102.05347870
16Renin secretion_Homo sapiens_hsa049241.99867508
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94006352
18Gastric acid secretion_Homo sapiens_hsa049711.84724447
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83266957
20Oxytocin signaling pathway_Homo sapiens_hsa049211.79220335
21Insulin secretion_Homo sapiens_hsa049111.77615429
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75543878
23Calcium signaling pathway_Homo sapiens_hsa040201.68553076
24Gap junction_Homo sapiens_hsa045401.67509779
25Long-term depression_Homo sapiens_hsa047301.57140201
26GnRH signaling pathway_Homo sapiens_hsa049121.48979662
27cAMP signaling pathway_Homo sapiens_hsa040241.42605668
28* Serotonergic synapse_Homo sapiens_hsa047261.42561495
29Taste transduction_Homo sapiens_hsa047421.36932613
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31335810
31Asthma_Homo sapiens_hsa053101.28591513
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27620722
33Glioma_Homo sapiens_hsa052141.25176930
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15450043
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08314108
36Estrogen signaling pathway_Homo sapiens_hsa049151.07691879
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.06536633
38Type II diabetes mellitus_Homo sapiens_hsa049301.05170799
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05114689
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.04063734
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.03418581
42Allograft rejection_Homo sapiens_hsa053301.00558091
43Melanogenesis_Homo sapiens_hsa049160.99179084
44ErbB signaling pathway_Homo sapiens_hsa040120.99125596
45Vitamin B6 metabolism_Homo sapiens_hsa007500.96719123
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95869628
47Axon guidance_Homo sapiens_hsa043600.93898720
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91842544
49Autoimmune thyroid disease_Homo sapiens_hsa053200.91829392
50Non-small cell lung cancer_Homo sapiens_hsa052230.91541167
51Graft-versus-host disease_Homo sapiens_hsa053320.90077397
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89921420
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88499843
54Oocyte meiosis_Homo sapiens_hsa041140.87890927
55Dorso-ventral axis formation_Homo sapiens_hsa043200.86766488
56Phototransduction_Homo sapiens_hsa047440.85677569
57* Alcoholism_Homo sapiens_hsa050340.83101218
58Rap1 signaling pathway_Homo sapiens_hsa040150.80871070
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79916546
60Dilated cardiomyopathy_Homo sapiens_hsa054140.78745436
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77099851
62Pancreatic secretion_Homo sapiens_hsa049720.76739395
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74210358
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72691825
65Choline metabolism in cancer_Homo sapiens_hsa052310.72632342
66Collecting duct acid secretion_Homo sapiens_hsa049660.72438048
67Thyroid hormone synthesis_Homo sapiens_hsa049180.72389057
68Cardiac muscle contraction_Homo sapiens_hsa042600.70310271
69MAPK signaling pathway_Homo sapiens_hsa040100.69919733
70VEGF signaling pathway_Homo sapiens_hsa043700.69695603
71Type I diabetes mellitus_Homo sapiens_hsa049400.69473472
72Primary immunodeficiency_Homo sapiens_hsa053400.69321876
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.68752009
74B cell receptor signaling pathway_Homo sapiens_hsa046620.67705253
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64645563
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.60608792
77mTOR signaling pathway_Homo sapiens_hsa041500.59956221
78Endocytosis_Homo sapiens_hsa041440.58481017
79Bile secretion_Homo sapiens_hsa049760.57406292
80Regulation of autophagy_Homo sapiens_hsa041400.55097514
81Rheumatoid arthritis_Homo sapiens_hsa053230.54828334
82Endometrial cancer_Homo sapiens_hsa052130.52674458
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51908692
84* Chemokine signaling pathway_Homo sapiens_hsa040620.51605397
85Prion diseases_Homo sapiens_hsa050200.51590497
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51352597
87* Ras signaling pathway_Homo sapiens_hsa040140.51230440
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49919718
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49438640
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49049976
91Renal cell carcinoma_Homo sapiens_hsa052110.48703571
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48374605
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47653654
94Tuberculosis_Homo sapiens_hsa051520.46711296
95Vibrio cholerae infection_Homo sapiens_hsa051100.46468575
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46188435
97Glucagon signaling pathway_Homo sapiens_hsa049220.45960334
98Ether lipid metabolism_Homo sapiens_hsa005650.44624236
99Arginine and proline metabolism_Homo sapiens_hsa003300.44601865
100Platelet activation_Homo sapiens_hsa046110.44341183
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43709907
102Leishmaniasis_Homo sapiens_hsa051400.43167592
103Ovarian steroidogenesis_Homo sapiens_hsa049130.40181130
104Histidine metabolism_Homo sapiens_hsa003400.37475187
105Inositol phosphate metabolism_Homo sapiens_hsa005620.36657663
106Staphylococcus aureus infection_Homo sapiens_hsa051500.36444343
107Butanoate metabolism_Homo sapiens_hsa006500.35110359
108Circadian rhythm_Homo sapiens_hsa047100.34951542
109Insulin signaling pathway_Homo sapiens_hsa049100.34830490
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34504845
111Arginine biosynthesis_Homo sapiens_hsa002200.34372102
112African trypanosomiasis_Homo sapiens_hsa051430.34308178
113beta-Alanine metabolism_Homo sapiens_hsa004100.33316218
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32970890
115Thyroid cancer_Homo sapiens_hsa052160.32777370
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31421998
117Alzheimers disease_Homo sapiens_hsa050100.31153695
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.29675341
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27774958
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27164088
121Tight junction_Homo sapiens_hsa045300.26243729

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