GNG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.98828823
2axon ensheathment in central nervous system (GO:0032291)9.98828823
3pyrimidine nucleobase catabolic process (GO:0006208)7.41801077
4phosphorelay signal transduction system (GO:0000160)6.62035712
5behavioral response to nicotine (GO:0035095)6.23703548
6modulation by virus of host process (GO:0019054)6.10553110
7fatty acid elongation (GO:0030497)5.98870822
8negative regulation of execution phase of apoptosis (GO:1900118)5.97898053
9nucleobase catabolic process (GO:0046113)5.68267860
10calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.22923696
11detection of calcium ion (GO:0005513)5.17330765
12long-chain fatty acid biosynthetic process (GO:0042759)5.08837576
13ensheathment of neurons (GO:0007272)4.82552422
14axon ensheathment (GO:0008366)4.82552422
15myelination (GO:0042552)4.81517456
16negative regulation of catenin import into nucleus (GO:0035414)4.72125156
17modulation by symbiont of host cellular process (GO:0044068)4.71592989
18establishment of mitochondrion localization (GO:0051654)4.64520782
19negative regulation of amino acid transport (GO:0051956)4.61134865
20dendritic spine morphogenesis (GO:0060997)4.60923232
21amyloid precursor protein metabolic process (GO:0042982)4.58280356
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.41156084
23substrate-independent telencephalic tangential migration (GO:0021826)4.41156084
24arginine catabolic process (GO:0006527)4.39627151
25protein neddylation (GO:0045116)4.33707554
26positive regulation of oligodendrocyte differentiation (GO:0048714)4.19180923
27regulation of glutamate secretion (GO:0014048)4.18795457
28retinal ganglion cell axon guidance (GO:0031290)4.18141423
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.16076335
30myelin maintenance (GO:0043217)4.15096552
31regulation of glycogen (starch) synthase activity (GO:2000465)4.11842717
32neuronal ion channel clustering (GO:0045161)4.07544612
33cell proliferation in forebrain (GO:0021846)4.07432067
34cellular response to virus (GO:0098586)3.97323507
35apical protein localization (GO:0045176)3.90961797
36negative regulation of neurotransmitter transport (GO:0051589)3.81799809
37cholesterol biosynthetic process (GO:0006695)3.81670954
38response to methylmercury (GO:0051597)3.81024841
39negative regulation of heart rate (GO:0010459)3.77634161
40negative regulation of neurotransmitter secretion (GO:0046929)3.76926394
41nerve growth factor signaling pathway (GO:0038180)3.71951744
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.69779012
43limb bud formation (GO:0060174)3.68476297
44glutathione biosynthetic process (GO:0006750)3.67724178
45epithelial cilium movement (GO:0003351)3.65733469
46neuronal action potential (GO:0019228)3.62019664
47neural tube formation (GO:0001841)3.61417729
48sterol biosynthetic process (GO:0016126)3.59072560
49regulation of protein targeting to membrane (GO:0090313)3.55344830
50neurofilament cytoskeleton organization (GO:0060052)3.54956040
51amyloid precursor protein catabolic process (GO:0042987)3.51574905
52cerebellar Purkinje cell differentiation (GO:0021702)3.51384887
53forebrain neuron differentiation (GO:0021879)3.48988567
54oligodendrocyte differentiation (GO:0048709)3.46937426
55axonal fasciculation (GO:0007413)3.44321438
56head development (GO:0060322)3.44070966
57synaptic transmission, cholinergic (GO:0007271)3.41046750
58negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.40464856
59regulation of collateral sprouting (GO:0048670)3.40218062
60spinal cord association neuron differentiation (GO:0021527)3.39962245
61negative regulation of amine transport (GO:0051953)3.39911362
62microtubule bundle formation (GO:0001578)3.39318753
63auditory behavior (GO:0031223)3.37965263
64parturition (GO:0007567)3.37672026
65glycerophospholipid catabolic process (GO:0046475)3.35574244
66asymmetric protein localization (GO:0008105)3.34559010
67pyrimidine ribonucleoside catabolic process (GO:0046133)3.34018956
68photoreceptor cell differentiation (GO:0046530)3.33918964
69eye photoreceptor cell differentiation (GO:0001754)3.33918964
70isoprenoid biosynthetic process (GO:0008299)3.32129664
71cytidine deamination (GO:0009972)3.31260975
72cytidine metabolic process (GO:0046087)3.31260975
73cytidine catabolic process (GO:0006216)3.31260975
74nonribosomal peptide biosynthetic process (GO:0019184)3.30927151
75negative regulation of glycogen biosynthetic process (GO:0045719)3.27972560
76protein localization to synapse (GO:0035418)3.26720906
77negative regulation of axon guidance (GO:1902668)3.26386806
78import into cell (GO:0098657)3.25232128
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24721252
80pyrimidine-containing compound catabolic process (GO:0072529)3.19589032
81negative regulation of protein localization to cell surface (GO:2000009)3.18021630
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17624196
83postsynaptic membrane organization (GO:0001941)3.17412341
84negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.17343027
85axonemal dynein complex assembly (GO:0070286)3.16696252
86transmission of nerve impulse (GO:0019226)3.16153134
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14204016
88cellular response to monoamine stimulus (GO:0071868)3.13775590
89cellular response to catecholamine stimulus (GO:0071870)3.13775590
90positive regulation of protein targeting to membrane (GO:0090314)3.13353498
91synapse assembly (GO:0007416)3.10981857
92positive regulation of growth hormone secretion (GO:0060124)3.10720503
93venous blood vessel morphogenesis (GO:0048845)3.10147943
94negative regulation of axon extension involved in axon guidance (GO:0048843)3.09007229
95neuron recognition (GO:0008038)3.08892880
96response to lipoprotein particle (GO:0055094)3.08276539
97activated T cell proliferation (GO:0050798)3.07849279
98peptide biosynthetic process (GO:0043043)3.07081071
99negative regulation of anoikis (GO:2000811)3.05850836
100response to monoamine (GO:0071867)3.05191718
101response to catecholamine (GO:0071869)3.05191718
102negative regulation of response to food (GO:0032096)3.04260677
103negative regulation of appetite (GO:0032099)3.04260677
104cellular response to gamma radiation (GO:0071480)3.04187017
105cilium movement (GO:0003341)3.03083744
106cellular response to prostaglandin stimulus (GO:0071379)3.02817041
107genetic imprinting (GO:0071514)3.01683459
108presynaptic membrane organization (GO:0097090)3.00883894
109protein polyglutamylation (GO:0018095)3.00301784
110protein targeting to Golgi (GO:0000042)2.99627198
111DNA deamination (GO:0045006)2.98109533
112interferon-gamma production (GO:0032609)2.97764750
113regulation of chromatin binding (GO:0035561)2.97408898
114axon extension (GO:0048675)2.95940286
115adipose tissue development (GO:0060612)2.95221969
116regulation of feeding behavior (GO:0060259)2.94857313
117L-amino acid import (GO:0043092)2.94013324
118sequestering of actin monomers (GO:0042989)2.93027851
119response to redox state (GO:0051775)2.89989885
120detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.88478445
121detection of temperature stimulus involved in sensory perception (GO:0050961)2.88478445
122establishment of protein localization to Golgi (GO:0072600)2.86769224
123cellular copper ion homeostasis (GO:0006878)2.86692433
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84098990
125arginine metabolic process (GO:0006525)2.84010802
126regulation of execution phase of apoptosis (GO:1900117)2.83829959
127vitamin A metabolic process (GO:0006776)2.82927274
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.82557464
129regulation of lipoprotein metabolic process (GO:0050746)2.82451694
130intraciliary transport (GO:0042073)2.80006217
131regulation of female receptivity (GO:0045924)2.79748765
132sensory perception of smell (GO:0007608)2.79249895
133regulation of synapse structural plasticity (GO:0051823)2.79184661
134positive regulation of mitochondrial fission (GO:0090141)2.78159374
135cellular biogenic amine catabolic process (GO:0042402)2.77999361
136amine catabolic process (GO:0009310)2.77999361
137mitochondrion transport along microtubule (GO:0047497)2.77451120
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77451120
139mating behavior (GO:0007617)2.76435587
140regulation of cilium movement (GO:0003352)2.75769391
141olfactory bulb development (GO:0021772)2.75492899
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75435404
143mechanosensory behavior (GO:0007638)2.74932202
144positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74608583
145mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74608583
146negative regulation of microtubule polymerization (GO:0031115)2.73846797
147substantia nigra development (GO:0021762)2.73531376
148axoneme assembly (GO:0035082)2.73010707
149regulation of microtubule-based movement (GO:0060632)2.72713549
150long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.71141028
151iron-sulfur cluster assembly (GO:0016226)2.70527588
152metallo-sulfur cluster assembly (GO:0031163)2.70527588
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70519771
154astrocyte development (GO:0014002)2.70435676
155spinal cord development (GO:0021510)2.70252435
156negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.69611695
157locomotory exploration behavior (GO:0035641)2.69567005
158adult walking behavior (GO:0007628)2.69480476
159modulation by virus of host morphology or physiology (GO:0019048)2.68034861
160peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.67492915
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67481692
162chaperone-mediated protein transport (GO:0072321)2.67214992
163positive regulation of amino acid transport (GO:0051957)2.67052211
164positive regulation of cAMP-mediated signaling (GO:0043950)2.66830324
165neuron cell-cell adhesion (GO:0007158)2.66434707
166mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.66317660
167protein localization to cilium (GO:0061512)2.66303830
168chondroitin sulfate catabolic process (GO:0030207)2.66147726
169negative regulation of cardiac muscle hypertrophy (GO:0010614)2.65792519
170ribonucleoprotein complex disassembly (GO:0032988)2.64052604
171creatine metabolic process (GO:0006600)2.63595195
172lysosome localization (GO:0032418)2.60218273
173positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59191452
174negative regulation of catecholamine secretion (GO:0033604)2.59053263
175sensory perception of chemical stimulus (GO:0007606)2.58894309
176regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.58579840
177regulation of telomere maintenance via telomerase (GO:0032210)2.57255516
178negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.57060816
179negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.56247836
180snRNA transcription (GO:0009301)2.55451805
181axon development (GO:0061564)2.55111398
182long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.53901190
183presynaptic membrane assembly (GO:0097105)2.50080928
184lateral sprouting from an epithelium (GO:0060601)2.49288475
185sensory perception of taste (GO:0050909)2.49103376
186release of cytochrome c from mitochondria (GO:0001836)2.48837455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14743983
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.17407833
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.14790335
4IKZF1_21737484_ChIP-ChIP_HCT116_Human2.97735220
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.91559850
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86885498
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68159265
8IGF1R_20145208_ChIP-Seq_DFB_Human2.52624035
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51967661
10GBX2_23144817_ChIP-Seq_PC3_Human2.40996087
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36505103
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36505103
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.25412459
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25221717
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15132551
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14891978
17VDR_22108803_ChIP-Seq_LS180_Human2.14600737
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07314536
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.07063524
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05300279
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04678594
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02374063
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.97258361
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95166463
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90965940
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87805755
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86823337
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85921012
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.85446469
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82416006
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.82136468
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82010843
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80762945
34TAF15_26573619_Chip-Seq_HEK293_Human1.80155160
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70409182
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64460392
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63140939
38ER_23166858_ChIP-Seq_MCF-7_Human1.60124387
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56588393
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55309587
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51736065
42DROSHA_22980978_ChIP-Seq_HELA_Human1.50934994
43AHR_22903824_ChIP-Seq_MCF-7_Human1.50557920
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.48998274
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.47903183
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46212606
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45337123
48IRF1_19129219_ChIP-ChIP_H3396_Human1.44314081
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42486708
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42109060
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40139854
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.39014146
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37161010
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36346097
55* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34825459
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33729381
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.33025868
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32857717
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30081101
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29599360
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28142842
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.27189836
63* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26189606
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23973148
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23424755
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22712677
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22499907
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21287049
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19823327
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14587450
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.14539408
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13732029
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12414524
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.11670826
75TP53_22573176_ChIP-Seq_HFKS_Human1.08663806
76TP53_18474530_ChIP-ChIP_U2OS_Human1.08538526
77P300_19829295_ChIP-Seq_ESCs_Human1.06968783
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05543857
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.05543514
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.04877905
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04609934
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.03398785
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03234069
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02568663
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02057412
86* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01314162
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99829472
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.98132730
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97204722
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97168445
91ZNF274_21170338_ChIP-Seq_K562_Hela0.96435209
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95559809
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95195949
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95195949
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93592844
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93582166
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.93107604
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92773741
99P300_18555785_Chip-Seq_ESCs_Mouse0.92283617
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91952638
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.91611871
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91545960
103ERA_21632823_ChIP-Seq_H3396_Human0.91487799
104NANOG_20526341_ChIP-Seq_ESCs_Human0.91301093
105* REST_18959480_ChIP-ChIP_MESCs_Mouse0.90912232
106STAT1_20625510_ChIP-Seq_HELA_Human0.90834631
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.90704110
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89691100
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89583706
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88300597
111NCOR_22424771_ChIP-Seq_293T_Human0.88078166
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87251701
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87216786
114RNF2_27304074_Chip-Seq_NSC_Mouse0.87200312
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86905307
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86313534
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85932943
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85576105
119RUNX2_22187159_ChIP-Seq_PCA_Human0.85467558
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85278438
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84461774
122SMAD4_21799915_ChIP-Seq_A2780_Human0.84060459
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83874326
124TAF2_19829295_ChIP-Seq_ESCs_Human0.83493986
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83189488
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.82838922
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.81678702
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.81467062
129CTCF_20526341_ChIP-Seq_ESCs_Human0.81128206
130JUN_21703547_ChIP-Seq_K562_Human0.81003834
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80881795
132P53_21459846_ChIP-Seq_SAOS-2_Human0.79693996
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79118110
134OCT4_20526341_ChIP-Seq_ESCs_Human0.78923478
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78510569
136* KDM2B_26808549_Chip-Seq_K562_Human0.78483985
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77858151
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77704723
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77704723
140* CTCF_27219007_Chip-Seq_Bcells_Human0.77654218
141* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77545383
142NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.77264021
143REST_21632747_ChIP-Seq_MESCs_Mouse0.77202920
144KDM2B_26808549_Chip-Seq_REH_Human0.77033373
145MYC_19829295_ChIP-Seq_ESCs_Human0.76965467
146SOX2_19829295_ChIP-Seq_ESCs_Human0.76254869
147NANOG_19829295_ChIP-Seq_ESCs_Human0.76254869
148EWS_26573619_Chip-Seq_HEK293_Human0.76013858
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75822713
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75705925
151RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75445081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.83983331
2MP0008789_abnormal_olfactory_epithelium3.79504766
3MP0000920_abnormal_myelination3.53220990
4MP0003123_paternal_imprinting3.41906567
5MP0005171_absent_coat_pigmentation3.15420122
6MP0003878_abnormal_ear_physiology3.12999402
7MP0005377_hearing/vestibular/ear_phenot3.12999402
8MP0003011_delayed_dark_adaptation3.11586971
9MP0005499_abnormal_olfactory_system3.11505584
10MP0005394_taste/olfaction_phenotype3.11505584
11MP0001485_abnormal_pinna_reflex3.05366345
12MP0001188_hyperpigmentation2.99208525
13MP0005645_abnormal_hypothalamus_physiol2.97768748
14MP0002653_abnormal_ependyma_morphology2.95681314
15MP0002822_catalepsy2.85865721
16MP0003122_maternal_imprinting2.73083450
17MP0003806_abnormal_nucleotide_metabolis2.68030288
18MP0003121_genomic_imprinting2.46148602
19MP0002163_abnormal_gland_morphology2.29799554
20MP0008438_abnormal_cutaneous_collagen2.28668388
21MP0003950_abnormal_plasma_membrane2.25135066
22MP0001984_abnormal_olfaction2.22513191
23MP0000778_abnormal_nervous_system2.19075595
24MP0004134_abnormal_chest_morphology2.15557057
25MP0005623_abnormal_meninges_morphology2.15434542
26MP0000372_irregular_coat_pigmentation2.11262901
27MP0000003_abnormal_adipose_tissue2.09963452
28MP0008877_abnormal_DNA_methylation2.07568249
29MP0003880_abnormal_central_pattern2.01625865
30MP0001486_abnormal_startle_reflex2.00337979
31MP0001905_abnormal_dopamine_level2.00221088
32MP0002909_abnormal_adrenal_gland1.93620736
33MP0004858_abnormal_nervous_system1.92412750
34MP0004145_abnormal_muscle_electrophysio1.90055227
35MP0001968_abnormal_touch/_nociception1.87103530
36MP0002272_abnormal_nervous_system1.86708474
37MP0003136_yellow_coat_color1.86441661
38MP0004742_abnormal_vestibular_system1.81618083
39MP0001542_abnormal_bone_strength1.79321492
40MP0002638_abnormal_pupillary_reflex1.78106223
41MP0004885_abnormal_endolymph1.77300710
42MP0005083_abnormal_biliary_tract1.73583428
43MP0005464_abnormal_platelet_physiology1.73248126
44MP0002733_abnormal_thermal_nociception1.66179074
45MP0000015_abnormal_ear_pigmentation1.58443345
46MP0003634_abnormal_glial_cell1.57822071
47MP0002736_abnormal_nociception_after1.55654672
48MP0006276_abnormal_autonomic_nervous1.55233550
49MP0002160_abnormal_reproductive_system1.54496911
50MP0002938_white_spotting1.50050111
51MP0005423_abnormal_somatic_nervous1.49604503
52MP0004811_abnormal_neuron_physiology1.48579719
53MP0003879_abnormal_hair_cell1.48388044
54MP0005410_abnormal_fertilization1.46849409
55MP0002734_abnormal_mechanical_nocicepti1.45627264
56MP0002229_neurodegeneration1.45082360
57MP0001963_abnormal_hearing_physiology1.44372065
58MP0005167_abnormal_blood-brain_barrier1.44106289
59MP0003690_abnormal_glial_cell1.43567038
60MP0009379_abnormal_foot_pigmentation1.43052468
61MP0002295_abnormal_pulmonary_circulatio1.41370871
62MP0001919_abnormal_reproductive_system1.40806857
63MP0004381_abnormal_hair_follicle1.38470440
64MP0005379_endocrine/exocrine_gland_phen1.37070793
65MP0001529_abnormal_vocalization1.36421849
66MP0002064_seizures1.36138066
67MP0003890_abnormal_embryonic-extraembry1.34535453
68MP0002882_abnormal_neuron_morphology1.33959672
69MP0002752_abnormal_somatic_nervous1.32396946
70MP0005084_abnormal_gallbladder_morpholo1.29213805
71MP0010386_abnormal_urinary_bladder1.29063472
72MP0002928_abnormal_bile_duct1.28524322
73MP0000026_abnormal_inner_ear1.28442876
74MP0002184_abnormal_innervation1.27929967
75MP0001348_abnormal_lacrimal_gland1.27818355
76MP0005389_reproductive_system_phenotype1.27002073
77MP0004859_abnormal_synaptic_plasticity1.26851227
78MP0000647_abnormal_sebaceous_gland1.24595213
79MP0005503_abnormal_tendon_morphology1.21724142
80MP0006292_abnormal_olfactory_placode1.18917692
81MP0000762_abnormal_tongue_morphology1.18352306
82MP0003632_abnormal_nervous_system1.16849844
83MP0003635_abnormal_synaptic_transmissio1.14737004
84MP0002233_abnormal_nose_morphology1.13399924
85MP0004142_abnormal_muscle_tone1.12670839
86MP0001440_abnormal_grooming_behavior1.12374641
87MP0010678_abnormal_skin_adnexa1.11754189
88MP0001346_abnormal_lacrimal_gland1.11238598
89MP0003938_abnormal_ear_development1.11230493
90MP0004130_abnormal_muscle_cell1.09670257
91MP0006072_abnormal_retinal_apoptosis1.08399453
92MP0003866_abnormal_defecation1.07324095
93MP0000383_abnormal_hair_follicle1.07298536
94MP0003631_nervous_system_phenotype1.06924585
95MP0005451_abnormal_body_composition1.05578656
96MP0009250_abnormal_appendicular_skeleto1.02605156
97MP0005253_abnormal_eye_physiology0.99143201
98MP0005671_abnormal_response_to0.99090325
99MP0000230_abnormal_systemic_arterial0.98920993
100MP0002102_abnormal_ear_morphology0.96961481
101MP0000955_abnormal_spinal_cord0.96602946
102MP0003329_amyloid_beta_deposits0.96543801
103MP0005275_abnormal_skin_tensile0.95785373
104MP0000467_abnormal_esophagus_morphology0.95358144
105MP0002572_abnormal_emotion/affect_behav0.94864780
106MP0004133_heterotaxia0.94721605
107MP0002751_abnormal_autonomic_nervous0.94539221
108MP0002152_abnormal_brain_morphology0.94155670
109MP0004924_abnormal_behavior0.93139677
110MP0005386_behavior/neurological_phenoty0.93139677
111MP0005551_abnormal_eye_electrophysiolog0.91658368
112MP0005408_hypopigmentation0.91574623
113MP0003937_abnormal_limbs/digits/tail_de0.91218579
114MP0001970_abnormal_pain_threshold0.90868911
115MP0005195_abnormal_posterior_eye0.90668892
116MP0009745_abnormal_behavioral_response0.88963227
117MP0003942_abnormal_urinary_system0.88469841
118MP0009046_muscle_twitch0.87060998
119MP0002063_abnormal_learning/memory/cond0.86750265
120MP0003656_abnormal_erythrocyte_physiolo0.86361535
121MP0008004_abnormal_stomach_pH0.86058191
122MP0002735_abnormal_chemical_nociception0.85015153
123MP0000631_abnormal_neuroendocrine_gland0.84325240
124MP0003861_abnormal_nervous_system0.84277443
125MP0001958_emphysema0.82721548
126MP0001727_abnormal_embryo_implantation0.81907766
127MP0002066_abnormal_motor_capabilities/c0.80779237
128MP0002557_abnormal_social/conspecific_i0.80394287
129MP0003646_muscle_fatigue0.80214311
130MP0008872_abnormal_physiological_respon0.79049680
131MP0002249_abnormal_larynx_morphology0.77317100
132MP0002067_abnormal_sensory_capabilities0.77136760
133MP0005409_darkened_coat_color0.76885724
134MP0005646_abnormal_pituitary_gland0.75402113
135MP0000566_synostosis0.74739039
136MP0005375_adipose_tissue_phenotype0.74126360
137MP0008569_lethality_at_weaning0.73917493
138MP0001340_abnormal_eyelid_morphology0.71042041
139MP0003137_abnormal_impulse_conducting0.69736058
140MP0003638_abnormal_response/metabolism_0.64987381
141MP0001177_atelectasis0.64364534
142MP0004147_increased_porphyrin_level0.64124076
143MP0004043_abnormal_pH_regulation0.63174936
144MP0000462_abnormal_digestive_system0.63119601
145MP0001293_anophthalmia0.62292337
146MP0002069_abnormal_eating/drinking_beha0.61501643
147MP0003633_abnormal_nervous_system0.60745758
148MP0003787_abnormal_imprinting0.59851848
149MP0005187_abnormal_penis_morphology0.59496359

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.56885717
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.56885717
3Retinal dysplasia (HP:0007973)4.95013473
4Neurofibrillary tangles (HP:0002185)4.34584327
5Papilledema (HP:0001085)4.27453714
6Parakeratosis (HP:0001036)4.24255810
7Abnormality of the corticospinal tract (HP:0002492)4.10505949
8Agitation (HP:0000713)3.91320496
9Abnormal pancreas size (HP:0012094)3.59720825
10Progressive cerebellar ataxia (HP:0002073)3.51291698
11Polyphagia (HP:0002591)3.50771696
12Anomalous pulmonary venous return (HP:0010772)3.32216877
13Methylmalonic acidemia (HP:0002912)3.26142407
14Cerebral inclusion bodies (HP:0100314)3.14483398
15Diastasis recti (HP:0001540)3.06064652
16Anosmia (HP:0000458)3.05526402
17Ankle clonus (HP:0011448)3.01636360
18Peripheral hypomyelination (HP:0007182)2.98845745
19Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98735727
20Hypoplasia of the iris (HP:0007676)2.97701113
21Drooling (HP:0002307)2.96161481
22Hyperthyroidism (HP:0000836)2.95062440
23Onion bulb formation (HP:0003383)2.94061563
24Hepatoblastoma (HP:0002884)2.92054654
25Nephronophthisis (HP:0000090)2.88810988
26Supranuclear gaze palsy (HP:0000605)2.86851468
27Abnormal ciliary motility (HP:0012262)2.82284044
28Abnormality of the pulmonary veins (HP:0011718)2.81801874
29Hypothermia (HP:0002045)2.80139666
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77768617
31Excessive salivation (HP:0003781)2.75882285
32Thyroid-stimulating hormone excess (HP:0002925)2.71367756
33Limb dystonia (HP:0002451)2.70844175
34Aplasia/Hypoplasia of the brainstem (HP:0007362)2.68469492
35Hypoplasia of the brainstem (HP:0002365)2.68469492
36Abnormality of midbrain morphology (HP:0002418)2.67848663
37Molar tooth sign on MRI (HP:0002419)2.67848663
38Spastic gait (HP:0002064)2.64855643
39Foot dorsiflexor weakness (HP:0009027)2.64565949
40Termporal pattern (HP:0011008)2.64176545
41Insidious onset (HP:0003587)2.64176545
42Pachygyria (HP:0001302)2.63979616
43Autoamputation (HP:0001218)2.60743484
44Neoplasm of the adrenal cortex (HP:0100641)2.59830003
45Myokymia (HP:0002411)2.58835611
46Scanning speech (HP:0002168)2.57823964
47Sensory axonal neuropathy (HP:0003390)2.57291960
48Rhinitis (HP:0012384)2.55350424
49Alacrima (HP:0000522)2.54592301
50Abnormality of dentin (HP:0010299)2.54232451
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54195177
52Septate vagina (HP:0001153)2.53707721
53Metaphyseal dysplasia (HP:0100255)2.53456746
54White forelock (HP:0002211)2.52170037
55Elevated erythrocyte sedimentation rate (HP:0003565)2.51799754
56Rib fusion (HP:0000902)2.51434832
57Stridor (HP:0010307)2.50873322
58Patchy hypopigmentation of hair (HP:0011365)2.48826509
59Poor suck (HP:0002033)2.48722942
60Spastic tetraplegia (HP:0002510)2.48486283
61Inability to walk (HP:0002540)2.48412217
62Febrile seizures (HP:0002373)2.45665968
63Failure to thrive in infancy (HP:0001531)2.41851293
64Infantile muscular hypotonia (HP:0008947)2.41775075
65Visual hallucinations (HP:0002367)2.40269282
66Xerostomia (HP:0000217)2.38923197
67Vaginal atresia (HP:0000148)2.36773437
68Segmental peripheral demyelination/remyelination (HP:0003481)2.36584306
69Abnormal respiratory motile cilium physiology (HP:0012261)2.35314044
70Abnormality of the foot musculature (HP:0001436)2.35034304
71Cortical dysplasia (HP:0002539)2.33916226
72Medial flaring of the eyebrow (HP:0010747)2.33789776
73Acute necrotizing encephalopathy (HP:0006965)2.32922948
74Split foot (HP:0001839)2.32782743
75Genital tract atresia (HP:0001827)2.32778827
76Lissencephaly (HP:0001339)2.30388177
77Neonatal hypoglycemia (HP:0001998)2.29258458
78Aplasia/Hypoplasia of the lens (HP:0008063)2.29034601
79Abnormality of the renal medulla (HP:0100957)2.28615683
80Hammertoe (HP:0001765)2.25905947
81Abnormal respiratory epithelium morphology (HP:0012253)2.23465254
82Abnormal respiratory motile cilium morphology (HP:0005938)2.23465254
83Hypoplastic left heart (HP:0004383)2.22024562
84Bony spicule pigmentary retinopathy (HP:0007737)2.21918397
85Fetal akinesia sequence (HP:0001989)2.21657350
86Hypoplastic pelvis (HP:0008839)2.20957958
87Gait imbalance (HP:0002141)2.20709401
883-Methylglutaconic aciduria (HP:0003535)2.19705146
89Thickened helices (HP:0000391)2.19541718
90Abnormal auditory evoked potentials (HP:0006958)2.18586645
91Absent eyebrow (HP:0002223)2.16484137
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13318869
93Abnormal mitochondria in muscle tissue (HP:0008316)2.12673883
94Amblyopia (HP:0000646)2.11491809
95Tubular atrophy (HP:0000092)2.10113259
96Premature rupture of membranes (HP:0001788)2.08069327
97Increased IgM level (HP:0003496)2.07982892
98Focal seizures (HP:0007359)2.07958776
99Submucous cleft hard palate (HP:0000176)2.06670662
100Petechiae (HP:0000967)2.05519662
101Myelomeningocele (HP:0002475)2.04934704
102Metabolic alkalosis (HP:0200114)2.04548091
103Growth hormone deficiency (HP:0000824)2.03821847
104Aplasia involving bones of the extremities (HP:0009825)2.03637829
105Aplasia involving bones of the upper limbs (HP:0009823)2.03637829
106Aplasia of the phalanges of the hand (HP:0009802)2.03637829
107Polymicrogyria (HP:0002126)2.02949283
108Premature skin wrinkling (HP:0100678)2.02695836
109Cerebral hypomyelination (HP:0006808)2.02280028
110Acute encephalopathy (HP:0006846)2.01863491
111Leukodystrophy (HP:0002415)2.01037176
112Chronic bronchitis (HP:0004469)1.99856874
113Amyloidosis (HP:0011034)1.99596175
114Adrenal hypoplasia (HP:0000835)1.98462941
115Abnormal rod and cone electroretinograms (HP:0008323)1.98407807
116Lower limb muscle weakness (HP:0007340)1.98116810
117Congenital ichthyosiform erythroderma (HP:0007431)1.97528624
118Congenital primary aphakia (HP:0007707)1.97027921
119Bell-shaped thorax (HP:0001591)1.96294988
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95590933
121Wormian bones (HP:0002645)1.95312869
122Impaired vibration sensation in the lower limbs (HP:0002166)1.93365934
123Muscle fiber splitting (HP:0003555)1.92781192
124Purpura (HP:0000979)1.91726379
125Disproportionate tall stature (HP:0001519)1.89221964
126Bilateral microphthalmos (HP:0007633)1.89185613
127Dysmetria (HP:0001310)1.89097598
128Mitochondrial inheritance (HP:0001427)1.88261945
129Abnormality of the intervertebral disk (HP:0005108)1.88245985
130Clumsiness (HP:0002312)1.87867661
131Type 2 muscle fiber atrophy (HP:0003554)1.86957955
132Intention tremor (HP:0002080)1.86908013
133Spastic tetraparesis (HP:0001285)1.86889317
134Abnormal hair whorl (HP:0010721)1.86359106
135Narrow forehead (HP:0000341)1.86241683
136Renal Fanconi syndrome (HP:0001994)1.86193035
137Morphological abnormality of the middle ear (HP:0008609)1.85116727
138Prolonged bleeding time (HP:0003010)1.84786611
139Enlarged kidneys (HP:0000105)1.83194062
140Amyotrophic lateral sclerosis (HP:0007354)1.82404848
141Bicornuate uterus (HP:0000813)1.81792318
142Abnormal eating behavior (HP:0100738)1.81527727
143Anophthalmia (HP:0000528)1.81278384
144Broad metatarsal (HP:0001783)1.80550514
145Absent septum pellucidum (HP:0001331)1.80439453
146Decreased lacrimation (HP:0000633)1.80378960
147Nephrogenic diabetes insipidus (HP:0009806)1.80168836
148Abnormality of the septum pellucidum (HP:0007375)1.80022018
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.79796001
150Absent/shortened dynein arms (HP:0200106)1.79796001
151Coronal craniosynostosis (HP:0004440)1.79341546
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79238287
153Abnormality of the vitamin B12 metabolism (HP:0004341)1.79083888
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78765829
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78765829
156Bradycardia (HP:0001662)1.78294534
157Progressive macrocephaly (HP:0004481)1.77036529
158Abnormality of molar morphology (HP:0011070)1.77031659
159Abnormality of molar (HP:0011077)1.77031659
160Optic disc pallor (HP:0000543)1.76762504
161Sclerocornea (HP:0000647)1.76347197
162Narrow nasal bridge (HP:0000446)1.76110955
163Megalencephaly (HP:0001355)1.75598342
164Methylmalonic aciduria (HP:0012120)1.74681960
165Axonal loss (HP:0003447)1.74613220
166Urinary bladder sphincter dysfunction (HP:0002839)1.74204272
167Bronchiectasis (HP:0002110)1.74008025
168Hypoplastic heart (HP:0001961)1.71379043
169Synostosis involving the elbow (HP:0003938)1.70558722
170Humeroradial synostosis (HP:0003041)1.70558722
171Congenital sensorineural hearing impairment (HP:0008527)1.70250848
172Aplasia/Hypoplasia of the spleen (HP:0010451)1.69866707
173Optic nerve coloboma (HP:0000588)1.69644011
174Decreased motor nerve conduction velocity (HP:0003431)1.68623521
175Slow saccadic eye movements (HP:0000514)1.67961541
176Restlessness (HP:0000711)1.67643885
177Menstrual irregularities (HP:0000858)1.66966161
178Focal motor seizures (HP:0011153)1.66601501
179Chronic sinusitis (HP:0011109)1.64481336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.42037373
2RIPK14.62719740
3STK394.40458503
4OXSR12.77104694
5PIM22.71923797
6MAP3K42.66906927
7MAPKAPK52.47131363
8CAMKK22.43700828
9BMPR22.36701463
10BRAF2.35442092
11IRAK22.35247601
12TXK2.34028790
13PRPF4B2.33735090
14ERBB32.22614136
15PINK12.21191734
16NUAK12.11407389
17EPHB22.02323612
18MAP4K22.00965560
19BCR1.83766001
20PKN11.83645632
21CSNK1A1L1.80958546
22CSNK1G31.79811899
23ADRBK21.79727105
24MAPK151.76499360
25EPHB11.74146655
26WNK31.73420308
27DDR21.70902046
28UHMK11.64441645
29NTRK31.63812032
30WNK41.57253683
31LIMK11.57167811
32MAP2K41.54743694
33CAMKK11.53249988
34DMPK1.51146091
35FGR1.49805593
36BMPR1B1.49190992
37PRKCG1.46498392
38DYRK31.45469355
39CAMK2B1.45410238
40FGFR21.45133660
41CSNK1G21.42679857
42EPHA31.37591058
43CSNK1G11.36223068
44CASK1.35998968
45ICK1.31919395
46SGK31.31793525
47MET1.31660462
48SGK2231.29883433
49SGK4941.29883433
50DYRK21.28171011
51CAMK1G1.24731165
52MAPK131.23708413
53TESK21.21470829
54RAF11.21124573
55WNK11.18904206
56CAMK2G1.16590728
57CAMK2D1.12952642
58CAMK11.12625005
59SIK21.09230912
60CAMK1D1.07297137
61MARK11.03665451
62MAP2K70.99568653
63CDK190.94575757
64ROCK20.94483307
65GRK70.93931090
66BTK0.93286291
67NTRK10.90124103
68ERBB20.90062865
69PIK3CA0.89713986
70PLK20.89666198
71ILK0.89484967
72TLK10.89317322
73BCKDK0.87846165
74TRIM280.86430104
75PNCK0.85182464
76DYRK1A0.84682234
77PRKCE0.83407269
78PBK0.83369393
79NTRK20.82395132
80PRKD10.80183798
81ADRBK10.77342637
82TYRO30.73598852
83RPS6KA50.72665348
84PRKCQ0.72131433
85MKNK10.72104391
86SYK0.69811207
87TRPM70.69492910
88GSK3A0.68738025
89MARK20.67586874
90MAP3K60.66330863
91PHKG20.66274739
92PHKG10.66274739
93SIK30.66048662
94PRKACA0.64747988
95AKT30.63020275
96PLK30.62988703
97EPHA40.60722735
98STK110.59634096
99CDK140.58786919
100PRKCD0.58161948
101PAK30.57491445
102HIPK20.57361972
103NEK60.55185435
104PRKCH0.54745623
105MAPKAPK20.54029954
106CAMK2A0.53888385
107MINK10.53168809
108DAPK20.53153304
109CDK150.53129832
110GRK50.52558224
111CAMK40.51753041
112CDK180.51372278
113PRKACG0.51326704
114SGK20.51306473
115RIPK40.51216295
116TNIK0.50439846
117ITK0.50352844
118STK160.50110161
119PRKG10.48667387
120CDK50.48069230
121MAP2K20.47801798
122PRKD30.47471142
123ERBB40.45883094
124MST40.45528134
125CDK11A0.45181003
126CLK10.45131229
127TAOK30.43296625
128LCK0.42524846
129PRKAA10.42014954
130PRKCZ0.41987054
131MAPK40.40582859
132SGK10.39620290
133FYN0.36333095
134ROCK10.35764128
135RPS6KA20.32985122
136PAK10.32108695
137MAP3K130.30470226
138PAK60.30264026
139PTK2B0.30138191
140MAP3K110.29827365
141PRKD20.29602562
142GRK10.28685485
143MATK0.27887231
144MAPK90.27194182
145PRKCI0.26920920
146AURKA0.26026735
147DYRK1B0.24624883
148PRKACB0.24261253
149TAOK10.24204196

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.95179730
2Steroid biosynthesis_Homo sapiens_hsa001004.15861781
3Fatty acid elongation_Homo sapiens_hsa000623.79025233
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.03428023
5Olfactory transduction_Homo sapiens_hsa047402.82756649
6Nicotine addiction_Homo sapiens_hsa050332.65813236
7Ether lipid metabolism_Homo sapiens_hsa005652.55578298
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53351503
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19263964
10Phototransduction_Homo sapiens_hsa047442.15343780
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02414913
12Collecting duct acid secretion_Homo sapiens_hsa049661.85951625
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82584205
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.81480909
15Histidine metabolism_Homo sapiens_hsa003401.76562292
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72807972
17* Serotonergic synapse_Homo sapiens_hsa047261.70993744
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70232912
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69344091
20Tight junction_Homo sapiens_hsa045301.60790986
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.57440711
22Protein export_Homo sapiens_hsa030601.56506372
23Oxidative phosphorylation_Homo sapiens_hsa001901.53611303
24Axon guidance_Homo sapiens_hsa043601.52941223
25* GABAergic synapse_Homo sapiens_hsa047271.49746965
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48487595
27Linoleic acid metabolism_Homo sapiens_hsa005911.45374831
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43062987
29* Glutamatergic synapse_Homo sapiens_hsa047241.39336262
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38790578
31* Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35313711
32Alzheimers disease_Homo sapiens_hsa050101.32523451
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32159454
34Primary immunodeficiency_Homo sapiens_hsa053401.31650080
35* Morphine addiction_Homo sapiens_hsa050321.31432504
36* Circadian entrainment_Homo sapiens_hsa047131.24065100
37Pyruvate metabolism_Homo sapiens_hsa006201.23647239
38Taste transduction_Homo sapiens_hsa047421.23436570
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.20431629
40Arginine and proline metabolism_Homo sapiens_hsa003301.18945995
41Parkinsons disease_Homo sapiens_hsa050121.16935368
42* Cholinergic synapse_Homo sapiens_hsa047251.10608603
43* Ras signaling pathway_Homo sapiens_hsa040141.08060343
44Insulin secretion_Homo sapiens_hsa049111.06478325
45Vitamin B6 metabolism_Homo sapiens_hsa007501.05590944
46Notch signaling pathway_Homo sapiens_hsa043301.05439148
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02172277
48* Dopaminergic synapse_Homo sapiens_hsa047280.98868572
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96600442
50Propanoate metabolism_Homo sapiens_hsa006400.96166308
51* Chemokine signaling pathway_Homo sapiens_hsa040620.96127651
52Long-term depression_Homo sapiens_hsa047300.95418392
53Salmonella infection_Homo sapiens_hsa051320.93266441
54Huntingtons disease_Homo sapiens_hsa050160.91085486
55Sphingolipid metabolism_Homo sapiens_hsa006000.89287327
56Sulfur metabolism_Homo sapiens_hsa009200.86910931
57Platelet activation_Homo sapiens_hsa046110.85115622
58T cell receptor signaling pathway_Homo sapiens_hsa046600.84344425
59Butanoate metabolism_Homo sapiens_hsa006500.78734674
60Chemical carcinogenesis_Homo sapiens_hsa052040.78537739
61Oxytocin signaling pathway_Homo sapiens_hsa049210.75946917
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75411393
63Arachidonic acid metabolism_Homo sapiens_hsa005900.75389224
64Type II diabetes mellitus_Homo sapiens_hsa049300.75221953
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.74339181
66Vibrio cholerae infection_Homo sapiens_hsa051100.74102818
67Renal cell carcinoma_Homo sapiens_hsa052110.72618689
68Synaptic vesicle cycle_Homo sapiens_hsa047210.72215140
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71729135
70Amphetamine addiction_Homo sapiens_hsa050310.71462769
71Hepatitis C_Homo sapiens_hsa051600.71245374
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70768187
73Asthma_Homo sapiens_hsa053100.70562326
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70090918
75cAMP signaling pathway_Homo sapiens_hsa040240.68309336
76Hematopoietic cell lineage_Homo sapiens_hsa046400.67454000
77Prion diseases_Homo sapiens_hsa050200.65751592
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65725824
79Autoimmune thyroid disease_Homo sapiens_hsa053200.65298489
80Ovarian steroidogenesis_Homo sapiens_hsa049130.63388113
81Fat digestion and absorption_Homo sapiens_hsa049750.62981815
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62958985
83RNA polymerase_Homo sapiens_hsa030200.62592535
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62583007
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.62331359
86ErbB signaling pathway_Homo sapiens_hsa040120.61953452
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60900070
88* Alcoholism_Homo sapiens_hsa050340.59978032
89Gastric acid secretion_Homo sapiens_hsa049710.59626931
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.59599091
91MAPK signaling pathway_Homo sapiens_hsa040100.58327459
92Glutathione metabolism_Homo sapiens_hsa004800.56820535
93Regulation of autophagy_Homo sapiens_hsa041400.54741617
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53034240
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52600094
96beta-Alanine metabolism_Homo sapiens_hsa004100.52450771
97Gap junction_Homo sapiens_hsa045400.52327741
98Mineral absorption_Homo sapiens_hsa049780.51936690
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51807694
100Phagosome_Homo sapiens_hsa041450.50807359
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50079648
102Basal cell carcinoma_Homo sapiens_hsa052170.49965713
103Cocaine addiction_Homo sapiens_hsa050300.49711912
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48851319
105Tyrosine metabolism_Homo sapiens_hsa003500.48594095
106Tryptophan metabolism_Homo sapiens_hsa003800.48531542
107* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48404985
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47658928
109Peroxisome_Homo sapiens_hsa041460.47168500
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.46062145
111Cardiac muscle contraction_Homo sapiens_hsa042600.45701782
112Graft-versus-host disease_Homo sapiens_hsa053320.45545655
113VEGF signaling pathway_Homo sapiens_hsa043700.45071370
114Hedgehog signaling pathway_Homo sapiens_hsa043400.44995036
115Calcium signaling pathway_Homo sapiens_hsa040200.44061051
116ECM-receptor interaction_Homo sapiens_hsa045120.43846316
117Ribosome_Homo sapiens_hsa030100.43222178
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41819176
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41186227
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41069686
121Allograft rejection_Homo sapiens_hsa053300.40216305
122Pancreatic cancer_Homo sapiens_hsa052120.39972087
123Glycerolipid metabolism_Homo sapiens_hsa005610.38851285
124Rheumatoid arthritis_Homo sapiens_hsa053230.38684839
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38206004
126Dilated cardiomyopathy_Homo sapiens_hsa054140.37572939
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36917096
128Melanogenesis_Homo sapiens_hsa049160.35504378
129Renin secretion_Homo sapiens_hsa049240.35434089
130Nitrogen metabolism_Homo sapiens_hsa009100.33994440
131GnRH signaling pathway_Homo sapiens_hsa049120.33560207
132Rap1 signaling pathway_Homo sapiens_hsa040150.33491201
133Melanoma_Homo sapiens_hsa052180.32180862
134Fatty acid metabolism_Homo sapiens_hsa012120.31988327
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30129517
136Endocytosis_Homo sapiens_hsa041440.30068608
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29814717
138Salivary secretion_Homo sapiens_hsa049700.29628745
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29447123
140* Pathways in cancer_Homo sapiens_hsa052000.27457264
141Endometrial cancer_Homo sapiens_hsa052130.26897485

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