GNGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of visible light (GO:0009584)9.97030686
2regulation of guanylate cyclase activity (GO:0031282)9.31595802
3protein-chromophore linkage (GO:0018298)9.08487167
4visual perception (GO:0007601)9.06384849
5sensory perception of light stimulus (GO:0050953)8.96259295
6photoreceptor cell differentiation (GO:0046530)7.88040630
7eye photoreceptor cell differentiation (GO:0001754)7.88040630
8* cellular response to light stimulus (GO:0071482)7.29001742
9* detection of external stimulus (GO:0009581)7.01860539
10retina development in camera-type eye (GO:0060041)7.00032513
11* detection of abiotic stimulus (GO:0009582)6.89014192
12regulation of cGMP metabolic process (GO:0030823)6.87734709
13positive regulation of cGMP biosynthetic process (GO:0030828)6.13164571
14regulation of cGMP biosynthetic process (GO:0030826)5.75014724
15positive regulation of cGMP metabolic process (GO:0030825)5.41834328
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.18790927
17nonmotile primary cilium assembly (GO:0035058)5.15854534
18cell morphogenesis involved in neuron differentiation (GO:0048667)4.90180434
19adaptation of signaling pathway (GO:0023058)4.90091879
20detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.81646525
21receptor guanylyl cyclase signaling pathway (GO:0007168)4.76928800
22* cellular response to radiation (GO:0071478)4.74750910
23proteasome assembly (GO:0043248)4.66250551
24DNA double-strand break processing (GO:0000729)4.42652366
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.42609177
26protein prenylation (GO:0018342)4.35980557
27prenylation (GO:0097354)4.35980557
28sensory perception (GO:0007600)4.28012736
29* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.22362380
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.19525542
31NADH dehydrogenase complex assembly (GO:0010257)4.19525542
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19525542
33regulation of voltage-gated calcium channel activity (GO:1901385)4.10663882
34response to pheromone (GO:0019236)4.06627311
35protein complex biogenesis (GO:0070271)3.91985233
36respiratory chain complex IV assembly (GO:0008535)3.91891801
37regulation of clathrin-mediated endocytosis (GO:2000369)3.88178731
38retina layer formation (GO:0010842)3.87226945
39protein neddylation (GO:0045116)3.85357194
40* response to light stimulus (GO:0009416)3.84901837
41peptidyl-histidine modification (GO:0018202)3.84065173
42mannosylation (GO:0097502)3.81192251
43retina homeostasis (GO:0001895)3.76859974
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70830526
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70585580
46mitochondrial respiratory chain complex assembly (GO:0033108)3.70054517
47negative regulation of receptor-mediated endocytosis (GO:0048261)3.68321567
48peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.63987245
49* neuron development (GO:0048666)3.63265880
50protein localization to synapse (GO:0035418)3.50691645
51cullin deneddylation (GO:0010388)3.49276514
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49095041
53estrogen biosynthetic process (GO:0006703)3.47619305
54DNA deamination (GO:0045006)3.40953923
55protein-cofactor linkage (GO:0018065)3.40220424
56platelet dense granule organization (GO:0060155)3.34912534
57behavioral response to ethanol (GO:0048149)3.34739168
58regulation of penile erection (GO:0060405)3.33093776
59short-term memory (GO:0007614)3.28507928
60protein deneddylation (GO:0000338)3.27431748
61cytochrome complex assembly (GO:0017004)3.27378695
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.24128662
63regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.24128662
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22332042
65histone H2A acetylation (GO:0043968)3.19936794
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18693911
67regulation of mitochondrial translation (GO:0070129)3.16871392
68regulation of cellular amino acid metabolic process (GO:0006521)3.16141298
69DNA catabolic process, exonucleolytic (GO:0000738)3.15300676
70response to histamine (GO:0034776)3.12796665
71behavioral response to nicotine (GO:0035095)3.12597223
72ATP synthesis coupled proton transport (GO:0015986)3.12555790
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12555790
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11641078
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10679377
76electron transport chain (GO:0022900)3.08808777
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08767963
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.07386609
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07362105
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07362105
81respiratory electron transport chain (GO:0022904)3.06828189
82L-methionine biosynthetic process (GO:0071265)3.03140908
83amino acid salvage (GO:0043102)3.03140908
84L-methionine salvage (GO:0071267)3.03140908
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02964357
86positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.02715290
87chemosensory behavior (GO:0007635)3.01668461
88chaperone-mediated protein transport (GO:0072321)3.01268373
89positive regulation of neurotransmitter transport (GO:0051590)3.01085943
90regulation of short-term neuronal synaptic plasticity (GO:0048172)2.99783400
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99329223
92ubiquinone biosynthetic process (GO:0006744)2.98597002
93base-excision repair, AP site formation (GO:0006285)2.98366128
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98253291
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95293506
96multicellular organism reproduction (GO:0032504)2.93495190
97water-soluble vitamin biosynthetic process (GO:0042364)2.92611916
98preassembly of GPI anchor in ER membrane (GO:0016254)2.91727940
99membrane hyperpolarization (GO:0060081)2.91622346
100axoneme assembly (GO:0035082)2.91541325
101termination of RNA polymerase III transcription (GO:0006386)2.91289906
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.91289906
103meiosis I (GO:0007127)2.90633953
104protein targeting to mitochondrion (GO:0006626)2.89849262
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88841793
106CDP-diacylglycerol biosynthetic process (GO:0016024)2.88102906
107retinoid metabolic process (GO:0001523)2.87214655
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86818124
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85582246
110chromatin remodeling at centromere (GO:0031055)2.84935116
111positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.84351960
112male meiosis I (GO:0007141)2.83902630
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83593912
114negative regulation of ligase activity (GO:0051352)2.83593912
115positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.83178732
116detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.82759550
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82407026
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82407026
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82407026
120pseudouridine synthesis (GO:0001522)2.81361899
121positive regulation of sodium ion transmembrane transport (GO:1902307)2.80063985
122icosanoid secretion (GO:0032309)2.77673003
123arachidonic acid secretion (GO:0050482)2.77673003
124ubiquinone metabolic process (GO:0006743)2.75371745
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75337839
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75337839
127CENP-A containing nucleosome assembly (GO:0034080)2.74950320
128regulation of meiosis I (GO:0060631)2.74718076
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74109138
130recombinational repair (GO:0000725)2.72866719
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.72291854
132establishment of protein localization to mitochondrion (GO:0072655)2.71658336
133deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71500030
134double-strand break repair via homologous recombination (GO:0000724)2.69652521
135DNA damage response, detection of DNA damage (GO:0042769)2.68311096
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67665983
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.67665983
138detection of chemical stimulus involved in sensory perception (GO:0050907)2.67647967
139* response to radiation (GO:0009314)2.66815697
140kynurenine metabolic process (GO:0070189)2.66254669
141protein localization to mitochondrion (GO:0070585)2.65710443
142negative regulation of cation channel activity (GO:2001258)2.65612866
143diterpenoid metabolic process (GO:0016101)2.65169484
144positive regulation of ERBB signaling pathway (GO:1901186)2.64654600
145post-embryonic morphogenesis (GO:0009886)2.63025728
146postreplication repair (GO:0006301)2.62466113
147L-fucose catabolic process (GO:0042355)2.62026670
148fucose catabolic process (GO:0019317)2.62026670
149L-fucose metabolic process (GO:0042354)2.62026670
150retinol metabolic process (GO:0042572)2.61071387
151regulation of cilium movement (GO:0003352)2.59784569
152sperm-egg recognition (GO:0035036)2.59416769
153positive regulation of ligase activity (GO:0051351)2.59245117
154negative regulation of calcium ion transmembrane transport (GO:1903170)2.58912804
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.58912804
156CDP-diacylglycerol metabolic process (GO:0046341)2.58472266
157spliceosomal snRNP assembly (GO:0000387)2.58351069
158reciprocal DNA recombination (GO:0035825)2.57066657
159reciprocal meiotic recombination (GO:0007131)2.57066657
160pyrimidine nucleotide catabolic process (GO:0006244)2.56939078
161somatic hypermutation of immunoglobulin genes (GO:0016446)2.56564572
162somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56564572
163oxidative phosphorylation (GO:0006119)2.56227897
164behavioral response to cocaine (GO:0048148)2.54972159
165DNA integration (GO:0015074)2.54703906
166replication fork processing (GO:0031297)2.54552652
167lipid translocation (GO:0034204)2.51826980
168phospholipid translocation (GO:0045332)2.51826980
169lipoprotein transport (GO:0042953)2.51313724
170positive regulation of cyclase activity (GO:0031281)2.48245540
171dopamine receptor signaling pathway (GO:0007212)2.47346930
172synaptic transmission, dopaminergic (GO:0001963)2.44518740
173synaptic vesicle maturation (GO:0016188)2.43806370
174terpenoid metabolic process (GO:0006721)2.41864659
175negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41461680
176protein heterotetramerization (GO:0051290)2.39762457
177synaptic vesicle docking involved in exocytosis (GO:0016081)2.39610093
178* cellular response to abiotic stimulus (GO:0071214)2.38347921
179negative regulation of mast cell activation (GO:0033004)2.33792138
180positive regulation of lyase activity (GO:0051349)2.29212013
181startle response (GO:0001964)2.23475602
182* regulation of rhodopsin mediated signaling pathway (GO:0022400)18.0512793
183* rhodopsin mediated signaling pathway (GO:0016056)17.6146492
184retinal cone cell development (GO:0046549)16.1293101
185* photoreceptor cell development (GO:0042461)12.5041660
186photoreceptor cell maintenance (GO:0045494)12.2228443
187* eye photoreceptor cell development (GO:0042462)11.8381432
188detection of light stimulus involved in sensory perception (GO:0050962)10.9449289
189detection of light stimulus involved in visual perception (GO:0050908)10.9449289
190GMP metabolic process (GO:0046037)10.8697392
191* phototransduction (GO:0007602)10.6098316
192* phototransduction, visible light (GO:0007603)10.3816105
193positive regulation of guanylate cyclase activity (GO:0031284)10.3210864
194retinal rod cell development (GO:0046548)10.1796848
195* detection of light stimulus (GO:0009583)10.0772856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43779573
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47454973
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.23177147
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.88354974
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.62057384
6ZNF274_21170338_ChIP-Seq_K562_Hela3.59346452
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21081734
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19454879
9VDR_22108803_ChIP-Seq_LS180_Human3.11256816
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.09474573
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83535411
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83517031
13GBX2_23144817_ChIP-Seq_PC3_Human2.82732541
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.64229602
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.49965458
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49934880
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38274700
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28210059
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26986282
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15280672
21VDR_23849224_ChIP-Seq_CD4+_Human2.13828503
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11550796
23EWS_26573619_Chip-Seq_HEK293_Human2.01570796
24TAF15_26573619_Chip-Seq_HEK293_Human1.99701707
25DROSHA_22980978_ChIP-Seq_HELA_Human1.99027098
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97618730
27ELK1_19687146_ChIP-ChIP_HELA_Human1.93428110
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88887007
29IRF1_19129219_ChIP-ChIP_H3396_Human1.88640566
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86085955
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.84044531
32MYC_18940864_ChIP-ChIP_HL60_Human1.83196291
33SMAD3_21741376_ChIP-Seq_HESCs_Human1.82949135
34FUS_26573619_Chip-Seq_HEK293_Human1.82838506
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79524673
36FOXP3_21729870_ChIP-Seq_TREG_Human1.78578084
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78219333
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72400223
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71359125
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71150755
41* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70996367
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.68534571
43IGF1R_20145208_ChIP-Seq_DFB_Human1.68067396
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.63238205
45AR_21572438_ChIP-Seq_LNCaP_Human1.63088671
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59699690
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59401737
48REST_21632747_ChIP-Seq_MESCs_Mouse1.59116334
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.56987061
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56783036
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54407706
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.54199658
53TP53_22573176_ChIP-Seq_HFKS_Human1.51702807
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.51600938
55AR_19668381_ChIP-Seq_PC3_Human1.46155663
56DCP1A_22483619_ChIP-Seq_HELA_Human1.45104305
57GABP_19822575_ChIP-Seq_HepG2_Human1.44791944
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43775682
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42587971
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.42465265
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41914744
62SMAD4_21799915_ChIP-Seq_A2780_Human1.41690819
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40365406
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39947058
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38289486
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36811404
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36124107
68TBL1_22424771_ChIP-Seq_293T_Human1.34987520
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31873638
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31873638
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.30059222
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.30026622
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29706697
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.29495979
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29282243
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.28504077
77E2F7_22180533_ChIP-Seq_HELA_Human1.28452338
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27880772
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27800932
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26588707
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.25912945
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.25669836
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25202609
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25085572
85P300_19829295_ChIP-Seq_ESCs_Human1.24834565
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23428905
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23121704
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.22308027
89AR_20517297_ChIP-Seq_VCAP_Human1.22182680
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.21466474
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21192876
92KDM2B_26808549_Chip-Seq_K562_Human1.21160228
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.21009305
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21009305
95ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20483398
96STAT3_23295773_ChIP-Seq_U87_Human1.19805965
97* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18269727
98NANOG_19829295_ChIP-Seq_ESCs_Human1.18045426
99SOX2_19829295_ChIP-Seq_ESCs_Human1.18045426
100BCAT_22108803_ChIP-Seq_LS180_Human1.17457297
101E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15382795
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15269527
103EZH2_22144423_ChIP-Seq_EOC_Human1.15096262
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14181621
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13744426
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.12640415
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11981372
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.11646761
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11352842
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.09244682
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09117302
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07374025
113CBP_21632823_ChIP-Seq_H3396_Human1.06804876
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05494509
115SMC4_20622854_ChIP-Seq_HELA_Human1.05233326
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04111464
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03901856
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03758313
119WDR5_24793694_ChIP-Seq_LNCAP_Human1.03663844
120AR_25329375_ChIP-Seq_VCAP_Human1.03452824
121GF1_26923725_Chip-Seq_HPCs_Mouse1.03368097
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02406542
123* GATA3_21878914_ChIP-Seq_MCF-7_Human1.01818345
124ER_23166858_ChIP-Seq_MCF-7_Human1.01782479
125HOXB7_26014856_ChIP-Seq_BT474_Human1.01646438
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01433371
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01344464
128TCF4_23295773_ChIP-Seq_U87_Human1.01034417
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00481394
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00377917
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00080028
132* TAF2_19829295_ChIP-Seq_ESCs_Human0.99831315
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99773521
134NCOR_22424771_ChIP-Seq_293T_Human0.99679074
135CTCF_27219007_Chip-Seq_Bcells_Human0.99660806
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.99124496
137FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99005575
138JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98978178
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.98151013
140EGR1_19032775_ChIP-ChIP_M12_Human0.98061806
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97960530
142MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97470405
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97050278
144TCF4_22108803_ChIP-Seq_LS180_Human0.96318149
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.96059056
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.95827064
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95536060
148CTCF_20526341_ChIP-Seq_ESCs_Human0.94972133
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94821985
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.94448191
151TTF2_22483619_ChIP-Seq_HELA_Human0.92901346
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92838071
153MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92824756
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.91824970
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.91621424
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90971505
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90376691
158RUNX_20019798_ChIP-Seq_JUKART_Human0.89746430
159YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89041510
160CBP_20019798_ChIP-Seq_JUKART_Human0.88832000
161IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88832000
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.88401205
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87918789
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87827680
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.87583206
166LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87426815
167VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87157398
168GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87038751
169PHF8_20622853_ChIP-Seq_HELA_Human0.86854887
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86573638
171NFE2_27457419_Chip-Seq_LIVER_Mouse0.86372391
172SMAD_19615063_ChIP-ChIP_OVARY_Human0.86346677
173BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86336212
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86092561
175CMYC_18555785_Chip-Seq_ESCs_Mouse0.85898245
176HTT_18923047_ChIP-ChIP_STHdh_Human0.85776625
177CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85683144
178* RNF2_27304074_Chip-Seq_NSC_Mouse0.85000168
179AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84452538
180KDM5A_27292631_Chip-Seq_BREAST_Human0.83414850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.91534240
2MP0006072_abnormal_retinal_apoptosis6.78091748
3* MP0005253_abnormal_eye_physiology6.64235003
4MP0003950_abnormal_plasma_membrane4.17376732
5* MP0005195_abnormal_posterior_eye3.94304556
6MP0001324_abnormal_eye_pigmentation3.75076578
7MP0002638_abnormal_pupillary_reflex3.47917741
8* MP0005391_vision/eye_phenotype3.21736342
9MP0008877_abnormal_DNA_methylation2.94277918
10MP0002090_abnormal_vision2.91659155
11MP0005423_abnormal_somatic_nervous2.56145531
12MP0000372_irregular_coat_pigmentation2.55390089
13* MP0002229_neurodegeneration2.46693127
14MP0002736_abnormal_nociception_after2.11985798
15MP0006276_abnormal_autonomic_nervous2.07690121
16MP0001986_abnormal_taste_sensitivity2.04403548
17MP0003011_delayed_dark_adaptation10.9023228
18MP0009697_abnormal_copulation1.96109150
19* MP0002752_abnormal_somatic_nervous1.93791343
20MP0003693_abnormal_embryo_hatching1.93464488
21MP0008875_abnormal_xenobiotic_pharmacok1.88653993
22MP0010094_abnormal_chromosome_stability1.87502315
23MP0003718_maternal_effect1.84673513
24MP0004147_increased_porphyrin_level1.83388263
25MP0003806_abnormal_nucleotide_metabolis1.73255797
26MP0008872_abnormal_physiological_respon1.72720579
27MP0001529_abnormal_vocalization1.70504812
28MP0002822_catalepsy1.63874781
29MP0003195_calcinosis1.58913327
30MP0003136_yellow_coat_color1.58782717
31MP0002837_dystrophic_cardiac_calcinosis1.58441498
32MP0006036_abnormal_mitochondrial_physio1.55989489
33* MP0001764_abnormal_homeostasis1.55717185
34MP0005084_abnormal_gallbladder_morpholo1.52922227
35MP0006035_abnormal_mitochondrial_morpho1.46397031
36MP0003186_abnormal_redox_activity1.43415178
37MP0002653_abnormal_ependyma_morphology1.42546725
38MP0008995_early_reproductive_senescence1.42333259
39MP0003786_premature_aging1.40871435
40* MP0002882_abnormal_neuron_morphology1.37649695
41MP0004019_abnormal_vitamin_homeostasis1.37393920
42MP0001485_abnormal_pinna_reflex1.33366288
43MP0001502_abnormal_circadian_rhythm1.31005090
44MP0001929_abnormal_gametogenesis1.27751906
45MP0002938_white_spotting1.25152476
46MP0005410_abnormal_fertilization1.24673386
47MP0003646_muscle_fatigue1.24604222
48MP0001293_anophthalmia1.23443767
49MP0002160_abnormal_reproductive_system1.18979055
50MP0005645_abnormal_hypothalamus_physiol1.14013343
51MP0003698_abnormal_male_reproductive1.12766124
52MP0002751_abnormal_autonomic_nervous1.12375587
53MP0006292_abnormal_olfactory_placode1.12144682
54MP0002210_abnormal_sex_determination1.11550008
55MP0005389_reproductive_system_phenotype1.11346865
56MP0005085_abnormal_gallbladder_physiolo1.09358782
57MP0001984_abnormal_olfaction1.09298444
58MP0005197_abnormal_uvea_morphology1.09149130
59MP0004133_heterotaxia1.07970880
60MP0003111_abnormal_nucleus_morphology1.04852525
61MP0008932_abnormal_embryonic_tissue1.03401759
62MP0000653_abnormal_sex_gland1.02721442
63MP0003077_abnormal_cell_cycle1.00548426
64MP0004957_abnormal_blastocyst_morpholog0.99711568
65MP0000049_abnormal_middle_ear0.95584818
66MP0001145_abnormal_male_reproductive0.95451378
67MP0004885_abnormal_endolymph0.94887317
68MP0003119_abnormal_digestive_system0.94254491
69MP0000358_abnormal_cell_content/0.94217583
70MP0004233_abnormal_muscle_weight0.92739632
71MP0005394_taste/olfaction_phenotype0.92634230
72MP0005499_abnormal_olfactory_system0.92634230
73MP0008007_abnormal_cellular_replicative0.92089954
74MP0002163_abnormal_gland_morphology0.90070648
75MP0005377_hearing/vestibular/ear_phenot0.89008129
76MP0003878_abnormal_ear_physiology0.89008129
77MP0002733_abnormal_thermal_nociception0.87493945
78MP0003937_abnormal_limbs/digits/tail_de0.87361878
79MP0005083_abnormal_biliary_tract0.87154067
80MP0002127_abnormal_cardiovascular_syste0.86689851
81MP0005187_abnormal_penis_morphology0.85073592
82MP0002735_abnormal_chemical_nociception0.84747465
83MP0001919_abnormal_reproductive_system0.83830475
84MP0001486_abnormal_startle_reflex0.83368590
85MP0003634_abnormal_glial_cell0.81650034
86MP0008789_abnormal_olfactory_epithelium0.81602768
87MP0005332_abnormal_amino_acid0.78169020
88MP0001119_abnormal_female_reproductive0.74636845
89MP0002332_abnormal_exercise_endurance0.74599881
90MP0003122_maternal_imprinting0.74071486
91MP0003137_abnormal_impulse_conducting0.73762317
92MP0004270_analgesia0.72921537
93MP0002272_abnormal_nervous_system0.70909856
94MP0001286_abnormal_eye_development0.62911524
95MP0003880_abnormal_central_pattern0.57058560
96MP0001963_abnormal_hearing_physiology0.53411825
97MP0004782_abnormal_surfactant_physiolog0.52909799
98MP0009046_muscle_twitch0.50476437
99MP0002064_seizures0.50314157
100MP0002734_abnormal_mechanical_nocicepti0.48087454
101MP0003635_abnormal_synaptic_transmissio0.41646739
102MP0000465_gastrointestinal_hemorrhage0.41459799
103MP0005248_abnormal_Harderian_gland0.41390582
104MP0002067_abnormal_sensory_capabilities0.40082618
105MP0004859_abnormal_synaptic_plasticity0.39608755
106MP0002063_abnormal_learning/memory/cond0.37913229
107MP0002572_abnormal_emotion/affect_behav0.37106706
108MP0008004_abnormal_stomach_pH0.36203333
109MP0000026_abnormal_inner_ear0.34702423
110MP0010386_abnormal_urinary_bladder0.34559729
111MP0009745_abnormal_behavioral_response0.33535874
112MP0004924_abnormal_behavior0.32858043
113MP0005386_behavior/neurological_phenoty0.32858043
114MP0000631_abnormal_neuroendocrine_gland0.31283468
115MP0003045_fibrosis0.30930133
116MP0002928_abnormal_bile_duct0.30389346
117MP0004215_abnormal_myocardial_fiber0.29374636
118* MP0005376_homeostasis/metabolism_phenot0.28706965
119MP0005595_abnormal_vascular_smooth0.28679844
120MP0001968_abnormal_touch/_nociception0.28599763
121MP0004085_abnormal_heartbeat0.26602271
122MP0005646_abnormal_pituitary_gland0.26267791
123MP0004742_abnormal_vestibular_system0.25794432
124MP0002102_abnormal_ear_morphology0.25416711
125MP0003252_abnormal_bile_duct0.24312586
126MP0004142_abnormal_muscle_tone0.24086178
127MP0004043_abnormal_pH_regulation0.24046285
128MP0002697_abnormal_eye_size0.23982544
129MP0005076_abnormal_cell_differentiation0.22987479
130MP0003890_abnormal_embryonic-extraembry0.22547671
131MP0005193_abnormal_anterior_eye0.22062034
132MP0005620_abnormal_muscle_contractility0.21270211
133MP0003943_abnormal_hepatobiliary_system0.20847582
134MP0002184_abnormal_innervation0.20184018
135MP0001188_hyperpigmentation0.19953584
136MP0008569_lethality_at_weaning0.19471819
137MP0002066_abnormal_motor_capabilities/c0.19408021
138MP0008058_abnormal_DNA_repair0.19145335
139MP0001905_abnormal_dopamine_level0.18135588
140MP0002152_abnormal_brain_morphology0.18091399
141MP0001915_intracranial_hemorrhage0.17358533
142MP0009780_abnormal_chondrocyte_physiolo0.16595934
143MP0004145_abnormal_muscle_electrophysio0.15515856
144MP0004811_abnormal_neuron_physiology0.15155197
145MP0003632_abnormal_nervous_system0.14870974
146MP0001177_atelectasis0.12599377
147MP0000647_abnormal_sebaceous_gland0.11992662
148MP0002234_abnormal_pharynx_morphology0.11878254
149MP0002557_abnormal_social/conspecific_i0.11870560
150MP0010030_abnormal_orbit_morphology0.11687999
151MP0005310_abnormal_salivary_gland0.10890824
152MP0003633_abnormal_nervous_system0.10183495
153MP0001661_extended_life_span0.09487146
154MP0001346_abnormal_lacrimal_gland0.09083653
155MP0003638_abnormal_response/metabolism_0.08839369
156MP0001879_abnormal_lymphatic_vessel0.08372462
157MP0003787_abnormal_imprinting0.08284983
158MP0002108_abnormal_muscle_morphology0.08092172
159MP0000778_abnormal_nervous_system0.07803676

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.53958884
2Pigmentary retinal degeneration (HP:0001146)9.43807387
3Pendular nystagmus (HP:0012043)8.30572239
4Dyschromatopsia (HP:0007641)8.08381724
5Central scotoma (HP:0000603)7.76958611
6Attenuation of retinal blood vessels (HP:0007843)7.57316762
7Abnormality of macular pigmentation (HP:0008002)7.19564217
8Abolished electroretinogram (ERG) (HP:0000550)7.02047557
9Scotoma (HP:0000575)6.95132518
10Decreased central vision (HP:0007663)6.40062943
11Type II diabetes mellitus (HP:0005978)5.65460894
12Photophobia (HP:0000613)5.62625715
13Vitreoretinal degeneration (HP:0000655)5.46916591
14Keratoconus (HP:0000563)5.33565446
15Increased corneal curvature (HP:0100692)5.33565446
16Macular degeneration (HP:0000608)5.04257866
17Severe visual impairment (HP:0001141)4.85348668
18Cone-rod dystrophy (HP:0000548)4.81524687
19Retinitis pigmentosa (HP:0000510)4.52038463
20Constricted visual fields (HP:0001133)4.28195575
21Choroideremia (HP:0001139)4.23157862
22Posterior subcapsular cataract (HP:0007787)4.21792765
23Acute necrotizing encephalopathy (HP:0006965)4.08392457
24Abnormal mitochondria in muscle tissue (HP:0008316)3.76857929
253-Methylglutaconic aciduria (HP:0003535)3.69763436
26Acute encephalopathy (HP:0006846)3.62107170
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.55389694
28Mitochondrial inheritance (HP:0001427)3.47950812
29Increased CSF lactate (HP:0002490)3.44269855
30Progressive macrocephaly (HP:0004481)3.37372198
31Progressive visual loss (HP:0000529)3.08517928
32Hepatocellular necrosis (HP:0001404)3.07342514
33Hepatic necrosis (HP:0002605)3.02390852
34Retinal atrophy (HP:0001105)2.98817419
35Cerebral edema (HP:0002181)2.94568639
36Generalized aminoaciduria (HP:0002909)2.71837917
37Optic disc pallor (HP:0000543)2.64318832
38Increased serum lactate (HP:0002151)2.61149452
39Gait imbalance (HP:0002141)2.57566520
40Congenital primary aphakia (HP:0007707)2.56621567
41Subcapsular cataract (HP:0000523)2.56102678
42Wide nasal bridge (HP:0000431)2.53677866
43Abnormality of the anterior horn cell (HP:0006802)2.53081842
44Degeneration of anterior horn cells (HP:0002398)2.53081842
45Lactic acidosis (HP:0003128)2.48042867
46Abnormality of the labia minora (HP:0012880)2.46189763
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34470279
48Abnormality of alanine metabolism (HP:0010916)2.34470279
49Hyperalaninemia (HP:0003348)2.34470279
50Hyperglycinemia (HP:0002154)2.34241757
51Nephrogenic diabetes insipidus (HP:0009806)2.31597980
52Congenital sensorineural hearing impairment (HP:0008527)2.29823044
53Type I transferrin isoform profile (HP:0003642)2.24621352
54Medial flaring of the eyebrow (HP:0010747)2.21770602
55Lethargy (HP:0001254)2.15380399
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13594998
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13594998
58Renal Fanconi syndrome (HP:0001994)2.11635779
59Methylmalonic acidemia (HP:0002912)2.09404785
60Lipid accumulation in hepatocytes (HP:0006561)2.06182349
61Increased hepatocellular lipid droplets (HP:0006565)2.04823274
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.04475763
63Respiratory failure (HP:0002878)2.04090727
64Male pseudohermaphroditism (HP:0000037)2.03583954
65Occipital encephalocele (HP:0002085)2.03050476
66Congenital stationary night blindness (HP:0007642)14.7638879
67Bony spicule pigmentary retinopathy (HP:0007737)11.6653770
68Absent rod-and cone-mediated responses on ERG (HP:0007688)10.9217797
69Abnormal rod and cone electroretinograms (HP:0008323)10.8393128
70Poor coordination (HP:0002370)1.98201422
71Exercise intolerance (HP:0003546)1.95638175
72Hyperglycinuria (HP:0003108)1.95575439
73Microvesicular hepatic steatosis (HP:0001414)1.95355877
74CNS demyelination (HP:0007305)1.93591700
75Abnormal protein glycosylation (HP:0012346)1.93528251
76Abnormal glycosylation (HP:0012345)1.93528251
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93528251
78Abnormal protein N-linked glycosylation (HP:0012347)1.93528251
79Short tibia (HP:0005736)1.92851916
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.92119731
81Methylmalonic aciduria (HP:0012120)1.89811119
82Type II lissencephaly (HP:0007260)1.89334620
83Meckel diverticulum (HP:0002245)1.88325783
84Hypothermia (HP:0002045)1.86287378
85Abnormality of serum amino acid levels (HP:0003112)1.85165921
86Abnormality of glycine metabolism (HP:0010895)1.85118047
87Abnormality of serine family amino acid metabolism (HP:0010894)1.85118047
88Birth length less than 3rd percentile (HP:0003561)1.83816200
89Retinal dysplasia (HP:0007973)1.82694462
90Abnormality of the ileum (HP:0001549)1.81857222
91Abnormality of the renal cortex (HP:0011035)1.80634896
92Glycosuria (HP:0003076)1.79986506
93Abnormality of urine glucose concentration (HP:0011016)1.79986506
94Vaginal atresia (HP:0000148)1.74827428
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74104275
96Preaxial hand polydactyly (HP:0001177)1.70956324
97Aplastic anemia (HP:0001915)1.70247916
98Increased intramyocellular lipid droplets (HP:0012240)1.69981114
99Inability to walk (HP:0002540)1.69935621
100Leukodystrophy (HP:0002415)1.68130242
101Progressive microcephaly (HP:0000253)1.67438134
102Genital tract atresia (HP:0001827)1.67034772
103Optic nerve hypoplasia (HP:0000609)1.66959140
104X-linked dominant inheritance (HP:0001423)1.64447520
105Optic atrophy (HP:0000648)1.64032664
106Interstitial pulmonary disease (HP:0006530)1.60379529
107True hermaphroditism (HP:0010459)1.58819210
108Severe Myopia (HP:0011003)1.50061110
109Aplasia/Hypoplasia of the lens (HP:0008063)1.48824714
110Horizontal nystagmus (HP:0000666)1.39255752
111Pancreatic fibrosis (HP:0100732)1.38430245
112Polar cataract (HP:0010696)1.37933622
113Abnormality of the fovea (HP:0000493)1.34639012
114Hypoplasia of the fovea (HP:0007750)1.34578141
115Aplasia/Hypoplasia of the fovea (HP:0008060)1.34578141
116Epileptic encephalopathy (HP:0200134)1.24786979
117Febrile seizures (HP:0002373)1.23288141
118Astigmatism (HP:0000483)1.20131864
119Dysdiadochokinesis (HP:0002075)1.17931265
120Pancreatic cysts (HP:0001737)1.16069874
121Cystic liver disease (HP:0006706)1.13936587
122Retinal detachment (HP:0000541)1.09865587
123Broad foot (HP:0001769)1.04665057
124Specific learning disability (HP:0001328)1.04528311
125Recurrent sinusitis (HP:0011108)1.03041790
126Chorioretinal coloboma (HP:0000567)1.02687382
127Left ventricular hypertrophy (HP:0001712)1.02484641
128Decreased testicular size (HP:0008734)0.98373061
129Asthma (HP:0002099)0.98256589
130Aplasia/Hypoplasia of the macula (HP:0008059)0.97637592
131Aplasia/Hypoplasia of the tongue (HP:0010295)0.96465954
132Cerebellar dysplasia (HP:0007033)0.95752677
133Sclerocornea (HP:0000647)0.88528638
134Aplasia/Hypoplasia affecting the retina (HP:0008061)0.86610069
135Hypermetropia (HP:0000540)0.85600413
136Visual hallucinations (HP:0002367)0.84773708
137Abnormality of midbrain morphology (HP:0002418)0.82087418
138Molar tooth sign on MRI (HP:0002419)0.82087418
139Progressive cerebellar ataxia (HP:0002073)0.78166508
140Partial agenesis of the corpus callosum (HP:0001338)0.75023810
141Furrowed tongue (HP:0000221)0.74563922
142Anencephaly (HP:0002323)0.74309047
143Truncal ataxia (HP:0002078)0.73576863
144Postaxial hand polydactyly (HP:0001162)0.73476968
145Chronic hepatic failure (HP:0100626)0.72872286
146Lymphopenia (HP:0001888)0.71179138
147Dental crowding (HP:0000678)0.69637699
148Congenital hepatic fibrosis (HP:0002612)0.69611107
149Hypodontia (HP:0000668)0.69454833
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.69363487
151Short foot (HP:0001773)0.68771421
152Prolonged QT interval (HP:0001657)0.66621650
153Albinism (HP:0001022)0.66382895
154Abnormality of cells of the lymphoid lineage (HP:0012140)0.64333634
155Nephrotic syndrome (HP:0000100)0.62435250
156Abnormality of dental color (HP:0011073)0.62386334
157Nephronophthisis (HP:0000090)0.62050568
158Postaxial foot polydactyly (HP:0001830)0.61027608
159Septo-optic dysplasia (HP:0100842)0.60474140
160Abnormality of the fingertips (HP:0001211)0.58486791
161Hirsutism (HP:0001007)0.56501467
162Generalized myoclonic seizures (HP:0002123)0.56161562
163Prominent nasal bridge (HP:0000426)0.55971050
164Abnormality of the renal medulla (HP:0100957)0.54994101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.30603750
2MAP4K23.91196770
3TRIM283.30233561
4PINK13.21683894
5BCKDK2.91796131
6IRAK22.79441947
7ZAK2.74280243
8BUB12.56665552
9MST42.25972010
10TESK22.11822475
11ADRBK22.09173821
12GRK110.8471189
13SRPK11.98409947
14STK161.92644624
15WNK31.86371642
16EIF2AK11.65725437
17VRK21.64069060
18MAP3K121.61496635
19BCR1.54530552
20ADRBK11.51553623
21SIK21.48585204
22TLK11.42545558
23MAPK71.40268214
24TSSK61.39814213
25INSRR1.36208509
26CSNK1G31.34572800
27ACVR1B1.32548845
28TAOK31.29935207
29NME11.28881332
30BRD41.28665912
31CDK191.27744174
32BMPR1B1.26319445
33PLK41.26068675
34VRK11.25019847
35MAPK121.23379087
36RPS6KA41.21040338
37CSNK1G11.20590976
38DYRK21.20512557
39SIK31.20250650
40BRSK21.18961643
41SGK4941.17286385
42SGK2231.17286385
43WNK41.15293436
44OXSR11.14663044
45AKT31.12694359
46SGK21.11012784
47EPHA41.10975836
48EIF2AK31.09658782
49CSNK1G21.08867782
50STK391.06597996
51HIPK21.06362792
52CSNK1A1L1.05253989
53WEE11.05186910
54PAK61.05004893
55NEK61.04417183
56MARK11.01359915
57DAPK11.00829442
58CCNB10.97921446
59CAMK1G0.96570757
60LIMK10.95327839
61ICK0.94140915
62CSNK1D0.94055033
63MAP3K100.92893005
64PRKCZ0.92256824
65PLK10.90103117
66STK380.89440577
67PRKCH0.88949013
68SGK30.87525287
69PRKD30.87213859
70MAP3K40.86501784
71MKNK20.83438548
72CDK120.82974179
73CDC70.82797267
74DYRK1A0.82501886
75DYRK30.81597674
76ATR0.80372591
77TXK0.78423649
78CDK30.77944468
79CAMK1D0.77426014
80BRSK10.77369964
81MAP2K70.76906715
82MAPKAPK30.74497648
83ERBB20.73011382
84MAPKAPK50.72391437
85GRK50.72228138
86KDR0.72178291
87PLK20.71792170
88CAMKK20.68815655
89PTK2B0.67654017
90PRKCB0.67504654
91PRKACG0.63261703
92TEC0.62744879
93PRKCE0.62667958
94FES0.62105326
95WNK10.61452061
96CAMK2D0.60515094
97PRKAA10.60300470
98PAK30.59753451
99FLT30.56342807
100IRAK10.55758610
101CASK0.54217437
102MAP3K50.53989771
103RPS6KA30.53572117
104CAMKK10.52905828
105PRPF4B0.52619264
106PDK20.52417076
107YES10.51806044
108TTK0.51526455
109PLK30.49047134
110PNCK0.48627455
111NEK10.48531276
112LATS10.47932872
113PRKAA20.47202121
114PIK3CA0.46516227
115CSNK2A10.45663533
116PRKD20.45299157
117ABL20.45159152
118SGK10.44638070
119PIM20.43615185
120ERBB30.43362293
121MAPK140.42667038
122PRKDC0.42318793
123CAMK2A0.41554519
124GSK3B0.41377268
125CAMK10.41111447
126MYLK0.39952579
127PKN10.38792402
128CSNK1A10.38064940
129DAPK20.37927538
130PHKG10.37915159
131PHKG20.37915159
132MAPK90.37032221
133MAPK130.36664917
134CAMK40.36634211
135TNK20.35718832
136DYRK1B0.35703316
137PRKCG0.35353777
138PRKACA0.35015225
139AURKB0.34847408
140NEK20.34793110
141RPS6KB10.34000522
142AURKA0.33756025
143CAMK2B0.33085891
144CHUK0.32238036
145CAMK2G0.31407205
146CDK10.31403377
147MAPK100.31190075
148CDK50.31152735
149MARK30.30928481
150STK30.30488370
151PRKCA0.29768901
152CDK90.29390079
153MKNK10.27036887
154NTRK30.25564888
155MAP3K70.23099957
156AKT20.23071400
157ATM0.22919307
158TNIK0.22247746
159FRK0.21796313
160RPS6KA50.21451923
161NUAK10.21276717
162MAPK30.20566353
163MINK10.20431860
164CHEK20.20350068
165MAPK80.18837894
166CHEK10.17066856

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71479532
2Oxidative phosphorylation_Homo sapiens_hsa001903.09486354
3Parkinsons disease_Homo sapiens_hsa050122.70841980
4Mismatch repair_Homo sapiens_hsa034302.48655992
5RNA polymerase_Homo sapiens_hsa030202.43577520
6Homologous recombination_Homo sapiens_hsa034402.39573600
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28695180
8DNA replication_Homo sapiens_hsa030302.06645413
9* Phototransduction_Homo sapiens_hsa0474416.1412370
10Protein export_Homo sapiens_hsa030601.91874016
11Huntingtons disease_Homo sapiens_hsa050161.88514367
12Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.85239132
13Fanconi anemia pathway_Homo sapiens_hsa034601.79682883
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72572736
15Base excision repair_Homo sapiens_hsa034101.67498256
16Pyrimidine metabolism_Homo sapiens_hsa002401.62676400
17Synaptic vesicle cycle_Homo sapiens_hsa047211.62552988
18Basal transcription factors_Homo sapiens_hsa030221.61494491
19One carbon pool by folate_Homo sapiens_hsa006701.60512945
20Butanoate metabolism_Homo sapiens_hsa006501.52418190
21Olfactory transduction_Homo sapiens_hsa047401.49739567
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48804752
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.46918485
24Alzheimers disease_Homo sapiens_hsa050101.46131148
25Non-homologous end-joining_Homo sapiens_hsa034501.45165287
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44056810
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42257147
28Propanoate metabolism_Homo sapiens_hsa006401.38531019
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32340428
30Regulation of autophagy_Homo sapiens_hsa041401.31333668
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.31304846
32Nucleotide excision repair_Homo sapiens_hsa034201.29935715
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27967015
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24527027
35RNA transport_Homo sapiens_hsa030131.21641965
36Glutathione metabolism_Homo sapiens_hsa004801.18869646
37Steroid biosynthesis_Homo sapiens_hsa001001.18515439
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17597281
39Spliceosome_Homo sapiens_hsa030401.14658541
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.12979037
41Selenocompound metabolism_Homo sapiens_hsa004501.12068668
42Peroxisome_Homo sapiens_hsa041461.07551399
43Chemical carcinogenesis_Homo sapiens_hsa052041.04614019
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98047632
45Tryptophan metabolism_Homo sapiens_hsa003800.97091525
46Ribosome_Homo sapiens_hsa030100.96397490
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95625328
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95206566
49Retinol metabolism_Homo sapiens_hsa008300.95121394
50* GABAergic synapse_Homo sapiens_hsa047270.94646883
51Circadian rhythm_Homo sapiens_hsa047100.94248120
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93169073
53Metabolic pathways_Homo sapiens_hsa011000.92676643
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88696620
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83953426
56Sulfur relay system_Homo sapiens_hsa041220.82870440
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78706464
58Pyruvate metabolism_Homo sapiens_hsa006200.77497851
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72356146
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72211280
61Sulfur metabolism_Homo sapiens_hsa009200.70542251
62Arachidonic acid metabolism_Homo sapiens_hsa005900.69963479
63* Cholinergic synapse_Homo sapiens_hsa047250.69571556
64Folate biosynthesis_Homo sapiens_hsa007900.68318356
65ABC transporters_Homo sapiens_hsa020100.65461809
66beta-Alanine metabolism_Homo sapiens_hsa004100.65139267
67* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63252404
68Nicotine addiction_Homo sapiens_hsa050330.60608930
69* Morphine addiction_Homo sapiens_hsa050320.57884503
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57466376
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57246668
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57240485
73* Glutamatergic synapse_Homo sapiens_hsa047240.55920959
74Nitrogen metabolism_Homo sapiens_hsa009100.55773130
75Fatty acid metabolism_Homo sapiens_hsa012120.54805874
76* Circadian entrainment_Homo sapiens_hsa047130.54042799
77Tyrosine metabolism_Homo sapiens_hsa003500.53667425
78* Dopaminergic synapse_Homo sapiens_hsa047280.51999707
79Insulin secretion_Homo sapiens_hsa049110.51261385
80Cell cycle_Homo sapiens_hsa041100.49465703
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48424416
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48119794
83Arginine and proline metabolism_Homo sapiens_hsa003300.47571649
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47398612
85Purine metabolism_Homo sapiens_hsa002300.46018983
86Fructose and mannose metabolism_Homo sapiens_hsa000510.45264394
87Primary immunodeficiency_Homo sapiens_hsa053400.45133268
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44441829
89* Serotonergic synapse_Homo sapiens_hsa047260.42540151
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42421898
91Vitamin B6 metabolism_Homo sapiens_hsa007500.42382616
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40685101
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40676317
94Oxytocin signaling pathway_Homo sapiens_hsa049210.40300149
95Carbon metabolism_Homo sapiens_hsa012000.40210517
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39108352
97Fat digestion and absorption_Homo sapiens_hsa049750.37364063
98Caffeine metabolism_Homo sapiens_hsa002320.36360360
99cAMP signaling pathway_Homo sapiens_hsa040240.34761802
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34553587
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34523999
102Fatty acid elongation_Homo sapiens_hsa000620.34049496
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34011406
104Oocyte meiosis_Homo sapiens_hsa041140.33251725
105Fatty acid degradation_Homo sapiens_hsa000710.32980587
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31220515
107Inositol phosphate metabolism_Homo sapiens_hsa005620.29394283
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29035534
109Renin secretion_Homo sapiens_hsa049240.28787543
110Dilated cardiomyopathy_Homo sapiens_hsa054140.28331602
111Glycerolipid metabolism_Homo sapiens_hsa005610.27664400
112Salivary secretion_Homo sapiens_hsa049700.27163271
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.27161440
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25948153
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.24446883
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23940438
117Cardiac muscle contraction_Homo sapiens_hsa042600.23442466
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22870914
119Galactose metabolism_Homo sapiens_hsa000520.22838409
120Cocaine addiction_Homo sapiens_hsa050300.22318262
121Arginine biosynthesis_Homo sapiens_hsa002200.21509342
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20941473
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.20059115
124mTOR signaling pathway_Homo sapiens_hsa041500.19548091
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18832594
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.18332324
127Type II diabetes mellitus_Homo sapiens_hsa049300.18189979
128Lysine degradation_Homo sapiens_hsa003100.17374845
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17221277
130Gastric acid secretion_Homo sapiens_hsa049710.17011949
131Calcium signaling pathway_Homo sapiens_hsa040200.16477933
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15616126
133Long-term potentiation_Homo sapiens_hsa047200.14258656
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14120956
135HIF-1 signaling pathway_Homo sapiens_hsa040660.14110398
136Amphetamine addiction_Homo sapiens_hsa050310.12793405
137Glucagon signaling pathway_Homo sapiens_hsa049220.12770742
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11674701
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11126136
140Linoleic acid metabolism_Homo sapiens_hsa005910.11082774
141* Chemokine signaling pathway_Homo sapiens_hsa040620.11037910
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10919551
143mRNA surveillance pathway_Homo sapiens_hsa030150.10214759
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.09886398
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09845084
146GnRH signaling pathway_Homo sapiens_hsa049120.09632148
147Collecting duct acid secretion_Homo sapiens_hsa049660.09342941
148AMPK signaling pathway_Homo sapiens_hsa041520.08801811
149Biosynthesis of amino acids_Homo sapiens_hsa012300.08738548
150MAPK signaling pathway_Homo sapiens_hsa040100.07717938
151Ether lipid metabolism_Homo sapiens_hsa005650.07064554
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06544359
153Mineral absorption_Homo sapiens_hsa049780.06138563
154RNA degradation_Homo sapiens_hsa030180.05587441
155Pancreatic secretion_Homo sapiens_hsa049720.05463163
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05131058
157Bile secretion_Homo sapiens_hsa049760.05104189
158* Alcoholism_Homo sapiens_hsa050340.04265926
159Taste transduction_Homo sapiens_hsa047420.03960806
160Phospholipase D signaling pathway_Homo sapiens_hsa040720.03090308
161Vitamin digestion and absorption_Homo sapiens_hsa049770.02446061
162Choline metabolism in cancer_Homo sapiens_hsa052310.02222321
163* Ras signaling pathway_Homo sapiens_hsa040140.01915425
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.01807011
165ErbB signaling pathway_Homo sapiens_hsa040120.01524447
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01407765
167Hippo signaling pathway_Homo sapiens_hsa043900.01340604
168Insulin resistance_Homo sapiens_hsa049310.01062975
169Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.00876411
170Rheumatoid arthritis_Homo sapiens_hsa053230.00700476
171Wnt signaling pathway_Homo sapiens_hsa04310-0.0031445

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