GNGT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.00789951
2neutrophil activation involved in immune response (GO:0002283)5.97084947
3purine nucleotide salvage (GO:0032261)4.95665934
4immunoglobulin mediated immune response (GO:0016064)4.92655080
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66340746
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66340746
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.66340746
8modulation by symbiont of host immune response (GO:0052553)4.66340746
9positive regulation by symbiont of host defense response (GO:0052509)4.66340746
10modulation by symbiont of host defense response (GO:0052031)4.66340746
11response to peptidoglycan (GO:0032494)4.63957729
12respiratory burst (GO:0045730)4.53823868
13folic acid-containing compound biosynthetic process (GO:0009396)4.52824034
14regulation of gamma-delta T cell activation (GO:0046643)4.40829443
15granulocyte activation (GO:0036230)4.40828312
16positive regulation of interferon-alpha production (GO:0032727)4.38568617
17neutrophil activation (GO:0042119)4.35816694
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.35298835
19negative regulation of cell killing (GO:0031342)4.35298835
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.27061576
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.27061576
22regulation of plasminogen activation (GO:0010755)4.26879304
23regulation of vitamin D biosynthetic process (GO:0060556)4.26071000
24homocysteine metabolic process (GO:0050667)4.20669222
25hydrogen peroxide biosynthetic process (GO:0050665)4.11829482
26regulation of interferon-alpha production (GO:0032647)4.11828746
27regulation of gamma-delta T cell differentiation (GO:0045586)4.06672718
28cytidine deamination (GO:0009972)4.05199774
29cytidine metabolic process (GO:0046087)4.05199774
30cytidine catabolic process (GO:0006216)4.05199774
31cellular response to zinc ion (GO:0071294)4.04682071
32macrophage activation involved in immune response (GO:0002281)4.00860010
33lipopolysaccharide-mediated signaling pathway (GO:0031663)4.00195478
34B cell mediated immunity (GO:0019724)3.88690170
35adenosine metabolic process (GO:0046085)3.81519640
36positive regulation of antigen processing and presentation (GO:0002579)3.81265391
37sulfur amino acid catabolic process (GO:0000098)3.79209151
38production of molecular mediator involved in inflammatory response (GO:0002532)3.77814614
39regulation of interferon-beta biosynthetic process (GO:0045357)3.75674557
40type I interferon signaling pathway (GO:0060337)3.70016246
41cellular response to type I interferon (GO:0071357)3.70016246
42response to type I interferon (GO:0034340)3.66992765
43T-helper 1 type immune response (GO:0042088)3.65130680
44reactive oxygen species biosynthetic process (GO:1903409)3.64013035
45response to muramyl dipeptide (GO:0032495)3.61842071
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60620229
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.57640083
48regulation of natural killer cell mediated immunity (GO:0002715)3.57640083
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.57160765
50T cell migration (GO:0072678)3.56256520
51positive regulation of mast cell degranulation (GO:0043306)3.54959406
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.54959406
53regulation of B cell receptor signaling pathway (GO:0050855)3.54449913
54myeloid cell activation involved in immune response (GO:0002275)3.52911236
55positive regulation of chemokine biosynthetic process (GO:0045080)3.52157465
56interferon-gamma-mediated signaling pathway (GO:0060333)3.51951831
57pyrimidine ribonucleoside catabolic process (GO:0046133)3.50961610
58positive thymic T cell selection (GO:0045059)3.49244599
59negative regulation of interleukin-1 beta production (GO:0032691)3.48643876
60superoxide anion generation (GO:0042554)3.47781306
61antigen processing and presentation of endogenous antigen (GO:0019883)3.47683635
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.46256964
63regulation of chronic inflammatory response (GO:0002676)3.46227428
64positive regulation of gamma-delta T cell activation (GO:0046645)3.44431657
65positive regulation of B cell differentiation (GO:0045579)3.43105930
66defense response to protozoan (GO:0042832)3.41201551
67regulation of vitamin metabolic process (GO:0030656)3.36809844
68response to interferon-beta (GO:0035456)3.34093990
69positive regulation of mast cell activation (GO:0033005)3.33651369
70myeloid dendritic cell differentiation (GO:0043011)3.33526636
71regulation of antigen processing and presentation (GO:0002577)3.30118998
72detection of molecule of bacterial origin (GO:0032490)3.28854976
73cellular extravasation (GO:0045123)3.27301025
74myeloid dendritic cell activation (GO:0001773)3.26920103
75natural killer cell mediated cytotoxicity (GO:0042267)3.24252644
76natural killer cell mediated immunity (GO:0002228)3.24252644
77regulation of B cell differentiation (GO:0045577)3.24219627
78cellular response to interferon-beta (GO:0035458)3.23137774
79positive regulation of interferon-beta production (GO:0032728)3.21166465
80regulation of T-helper 1 cell differentiation (GO:0045625)3.20379140
81B cell receptor signaling pathway (GO:0050853)3.20136399
82positive regulation of humoral immune response (GO:0002922)3.19585151
83regulation of mast cell degranulation (GO:0043304)3.19476628
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.18141725
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16743809
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16667750
87regulation of T cell tolerance induction (GO:0002664)3.16067375
88positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.15476646
89chemokine-mediated signaling pathway (GO:0070098)3.14171256
90T cell costimulation (GO:0031295)3.13326490
91positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12990086
92regulation of hypersensitivity (GO:0002883)3.12263214
93lymphocyte costimulation (GO:0031294)3.12066641
94cellular response to interleukin-15 (GO:0071350)3.10987400
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10759540
96response to host immune response (GO:0052572)3.10759540
97microtubule nucleation (GO:0007020)3.10573730
98positive regulation of natural killer cell mediated immunity (GO:0002717)3.10309732
99regulation of interleukin-12 biosynthetic process (GO:0045075)3.10124430
100regulation of alpha-beta T cell proliferation (GO:0046640)3.09480522
101positive regulation of cellular amide metabolic process (GO:0034250)3.09041837
102leukocyte mediated cytotoxicity (GO:0001909)3.08535172
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08043845
104positive regulation of interleukin-12 production (GO:0032735)3.05518265
105macrophage activation (GO:0042116)3.05517532
106detection of bacterium (GO:0016045)3.05106937
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04295465
108detection of other organism (GO:0098543)3.03715521
109lymphocyte mediated immunity (GO:0002449)3.03009710
110negative regulation of interleukin-17 production (GO:0032700)3.02674078
111phosphatidylglycerol biosynthetic process (GO:0006655)3.02293086
112positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.01292109
113leukocyte aggregation (GO:0070486)3.01204728
114response to protozoan (GO:0001562)3.01137511
115myeloid leukocyte activation (GO:0002274)2.99361529
116cysteine metabolic process (GO:0006534)2.98180221
117regulation of chemokine biosynthetic process (GO:0045073)2.98074689
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97945248
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97945248
120regulation of mast cell activation involved in immune response (GO:0033006)2.97419922
121response to interferon-alpha (GO:0035455)2.97003406
122regulation of superoxide anion generation (GO:0032928)2.96386525
123regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95178085
124nucleotide salvage (GO:0043173)2.94652931
125microglial cell activation (GO:0001774)2.94321651
126negative regulation of viral genome replication (GO:0045071)2.93978531
127adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.93823650
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93399555
129positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.92966950
130positive regulation of B cell mediated immunity (GO:0002714)2.90093893
131positive regulation of immunoglobulin mediated immune response (GO:0002891)2.90093893
132positive regulation of monocyte chemotaxis (GO:0090026)2.90058399
133regulation of mononuclear cell migration (GO:0071675)2.89705318
134negative regulation of interleukin-1 production (GO:0032692)2.89271657
135positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.89172029
136regulation of regulatory T cell differentiation (GO:0045589)2.88575236
137regulation of mast cell activation (GO:0033003)2.87987119
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87817109
139interferon-gamma production (GO:0032609)2.87622525
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87417274
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.86421814
142negative regulation of interleukin-12 production (GO:0032695)2.86242714
143cell migration involved in heart development (GO:0060973)2.85570491
144positive regulation of endothelial cell differentiation (GO:0045603)2.84733532
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84503797
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83710919
147monocyte chemotaxis (GO:0002548)2.83272184
148dendritic cell differentiation (GO:0097028)2.82838794
149regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82416629
150regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82126094
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.81876660
152negative T cell selection (GO:0043383)2.81853314
153negative thymic T cell selection (GO:0045060)2.81080919
154T cell selection (GO:0045058)2.80884520
155response to interleukin-15 (GO:0070672)2.80485643
156positive regulation of calcium-mediated signaling (GO:0050850)2.80219451
157NIK/NF-kappaB signaling (GO:0038061)2.79972854
158cellular response to interferon-gamma (GO:0071346)2.78329774
159DNA deamination (GO:0045006)2.78192483
160positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77823042
161positive T cell selection (GO:0043368)2.77355555
162natural killer cell differentiation (GO:0001779)2.77203103
163positive regulation of cytokine biosynthetic process (GO:0042108)2.76834940
164cellular response to virus (GO:0098586)2.76747019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.57939917
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.79082274
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.37016701
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.92509120
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.39154603
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19845993
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.05699756
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02745628
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.79237566
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58270912
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36888816
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32843679
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18868009
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02642462
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85612457
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.82249317
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72065643
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65007776
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61599049
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47238852
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44003532
22SPI1_23547873_ChIP-Seq_NB4_Human2.34759068
23SCL_19346495_ChIP-Seq_HPC-7_Human2.24939377
24RUNX_20019798_ChIP-Seq_JUKART_Human1.99143314
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94986461
26MYB_26560356_Chip-Seq_TH2_Human1.90537470
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89377537
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86559537
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86166757
30MAF_26560356_Chip-Seq_TH1_Human1.82528318
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79325514
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73412512
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71917957
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71702187
35VDR_24763502_ChIP-Seq_THP-1_Human1.70917253
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.70763752
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69798366
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64366732
39MYB_26560356_Chip-Seq_TH1_Human1.63850012
40SPI1_23127762_ChIP-Seq_K562_Human1.61608043
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60984429
42VDR_21846776_ChIP-Seq_THP-1_Human1.54882068
43* PU_27001747_Chip-Seq_BMDM_Mouse1.54592892
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54267927
45* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53736563
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47707107
47* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44232272
48VDR_24787735_ChIP-Seq_THP-1_Human1.41591636
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37602857
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35858934
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33892113
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32049710
53UTX_26944678_Chip-Seq_JUKART_Human1.31312444
54MYC_22102868_ChIP-Seq_BL_Human1.27864802
55GATA3_27048872_Chip-Seq_THYMUS_Human1.27666982
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25927404
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25206010
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.25036698
59TCF7_22412390_ChIP-Seq_EML_Mouse1.21117939
60LXR_22292898_ChIP-Seq_THP-1_Human1.17636134
61STAT1_20625510_ChIP-Seq_HELA_Human1.15987238
62BCOR_27268052_Chip-Seq_Bcells_Human1.14592843
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11355833
64CIITA_25753668_ChIP-Seq_RAJI_Human1.11351946
65GATA3_26560356_Chip-Seq_TH2_Human1.10814867
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10484359
67MAF_26560356_Chip-Seq_TH2_Human1.08359251
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08045524
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07627170
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05635051
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.04905331
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01097802
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00233807
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00233807
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00233807
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98861760
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97749808
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.96606233
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96361504
80YY1_22570637_ChIP-Seq_MALME-3M_Human0.95720382
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95012863
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.93352934
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92765289
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92054025
85TP63_17297297_ChIP-ChIP_HaCaT_Human0.91483620
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90563365
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90138559
88* GATA1_19941827_ChIP-Seq_MEL_Mouse0.87450142
89P300_27268052_Chip-Seq_Bcells_Human0.85795322
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84316981
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84272671
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84179325
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.83282155
94FOXP3_21729870_ChIP-Seq_TREG_Human0.82834983
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82568678
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82511230
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80993149
98GATA1_22025678_ChIP-Seq_K562_Human0.80964184
99GATA3_26560356_Chip-Seq_TH1_Human0.80606193
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77955391
101P68_20966046_ChIP-Seq_HELA_Human0.77356888
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77047317
103SPI1_20517297_ChIP-Seq_HL60_Human0.76998999
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76137870
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75008147
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74338790
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74204161
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73847787
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73175473
110KDM2B_26808549_Chip-Seq_DND41_Human0.72644249
111EGR1_19032775_ChIP-ChIP_M12_Human0.72156362
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72088661
113NCOR1_26117541_ChIP-Seq_K562_Human0.70897528
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67814711
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65513332
116BCL6_27268052_Chip-Seq_Bcells_Human0.65240747
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65175751
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64065984
119TFEB_21752829_ChIP-Seq_HELA_Human0.62339337
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.58901599
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58096058
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.57915642
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.57570568
124SMRT_27268052_Chip-Seq_Bcells_Human0.57238239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.26794911
2MP0003436_decreased_susceptibility_to3.99089132
3MP0002148_abnormal_hypersensitivity_rea3.74198909
4MP0009785_altered_susceptibility_to3.72346831
5MP0005000_abnormal_immune_tolerance3.24656041
6MP0005387_immune_system_phenotype3.17704871
7MP0001790_abnormal_immune_system3.17704871
8MP0000685_abnormal_immune_system3.16637170
9MP0005671_abnormal_response_to3.09866893
10MP0002419_abnormal_innate_immunity3.06952447
11MP0005025_abnormal_response_to3.04179588
12MP0003724_increased_susceptibility_to3.01124058
13MP0006082_CNS_inflammation2.92994143
14MP0001800_abnormal_humoral_immune2.85256336
15MP0002452_abnormal_antigen_presenting2.84444467
16MP0002723_abnormal_immune_serum2.65652499
17MP0001819_abnormal_immune_cell2.45848785
18MP0002420_abnormal_adaptive_immunity2.43992946
19MP0004510_myositis2.41320387
20MP0003806_abnormal_nucleotide_metabolis2.40767898
21MP0003303_peritoneal_inflammation2.24060597
22MP0005360_urolithiasis2.18643949
23MP0003011_delayed_dark_adaptation2.08894667
24MP0005058_abnormal_lysosome_morphology2.00992343
25MP0002405_respiratory_system_inflammati1.99272500
26MP0001533_abnormal_skeleton_physiology1.98022065
27MP0001853_heart_inflammation1.96317698
28MP0005464_abnormal_platelet_physiology1.94467855
29MP0002006_tumorigenesis1.92321929
30MP0001845_abnormal_inflammatory_respons1.85092842
31MP0000716_abnormal_immune_system1.84061612
32MP0003191_abnormal_cellular_cholesterol1.79771046
33MP0009764_decreased_sensitivity_to1.78234068
34MP0009333_abnormal_splenocyte_physiolog1.76780960
35MP0002398_abnormal_bone_marrow1.76167725
36MP0002166_altered_tumor_susceptibility1.72973692
37MP0004947_skin_inflammation1.64007650
38MP0005310_abnormal_salivary_gland1.63860974
39MP0008469_abnormal_protein_level1.62698348
40MP0005670_abnormal_white_adipose1.62565320
41MP0010155_abnormal_intestine_physiology1.62501944
42MP0000343_altered_response_to1.54782004
43MP0003448_altered_tumor_morphology1.54586145
44MP0003075_altered_response_to1.52332336
45MP0002429_abnormal_blood_cell1.50159713
46MP0003705_abnormal_hypodermis_morpholog1.48153899
47MP0000689_abnormal_spleen_morphology1.47243454
48MP0002722_abnormal_immune_system1.39391727
49MP0002138_abnormal_hepatobiliary_system1.36232522
50MP0002998_abnormal_bone_remodeling1.30842374
51MP0000858_altered_metastatic_potential1.30168646
52MP0003172_abnormal_lysosome_physiology1.28386734
53MP0002254_reproductive_system_inflammat1.28374236
54MP0004782_abnormal_surfactant_physiolog1.28054747
55MP0003866_abnormal_defecation1.26721491
56MP0002277_abnormal_respiratory_mucosa1.25843667
57MP0002139_abnormal_hepatobiliary_system1.11663492
58MP0005167_abnormal_blood-brain_barrier1.11504606
59MP0008995_early_reproductive_senescence1.11412574
60MP0005646_abnormal_pituitary_gland1.11376836
61MP0003828_pulmonary_edema1.11303984
62MP0009278_abnormal_bone_marrow1.10147953
63MP0005166_decreased_susceptibility_to1.09509849
64MP0003763_abnormal_thymus_physiology1.09465629
65MP0004185_abnormal_adipocyte_glucose1.08829002
66MP0001661_extended_life_span1.08712221
67MP0001545_abnormal_hematopoietic_system1.07985660
68MP0005397_hematopoietic_system_phenotyp1.07985660
69MP0001764_abnormal_homeostasis1.02131551
70MP0002396_abnormal_hematopoietic_system1.02047712
71MP0002163_abnormal_gland_morphology1.00072178
72MP0003186_abnormal_redox_activity0.98263813
73MP0001879_abnormal_lymphatic_vessel0.96932792
74MP0005390_skeleton_phenotype0.96910091
75MP0009840_abnormal_foam_cell0.96306698
76MP0002933_joint_inflammation0.95751301
77MP0000013_abnormal_adipose_tissue0.95130308
78MP0000465_gastrointestinal_hemorrhage0.92670490
79MP0005451_abnormal_body_composition0.90503576
80MP0009763_increased_sensitivity_to0.90008155
81MP0000249_abnormal_blood_vessel0.88772844
82MP0001851_eye_inflammation0.88020694
83MP0005551_abnormal_eye_electrophysiolog0.87658494
84MP0005253_abnormal_eye_physiology0.86740297
85MP0005076_abnormal_cell_differentiation0.85025490
86MP0006292_abnormal_olfactory_placode0.80488740
87MP0000767_abnormal_smooth_muscle0.80338501
88MP0000371_diluted_coat_color0.79738769
89MP0005164_abnormal_response_to0.77965654
90MP0000703_abnormal_thymus_morphology0.75452217
91MP0002090_abnormal_vision0.75409652
92MP0003183_abnormal_peptide_metabolism0.75391044
93MP0000490_abnormal_crypts_of0.75091126
94MP0004808_abnormal_hematopoietic_stem0.74714672
95MP0001663_abnormal_digestive_system0.72995894
96MP0002332_abnormal_exercise_endurance0.72841313
97MP0000516_abnormal_urinary_system0.70706416
98MP0005367_renal/urinary_system_phenotyp0.70706416
99MP0009643_abnormal_urine_homeostasis0.70266703
100MP0001324_abnormal_eye_pigmentation0.69983274
101MP0001873_stomach_inflammation0.69513105
102MP0002095_abnormal_skin_pigmentation0.69404219
103MP0001348_abnormal_lacrimal_gland0.69076178
104MP0009765_abnormal_xenobiotic_induced0.68622503
105MP0005174_abnormal_tail_pigmentation0.66368138
106MP0002693_abnormal_pancreas_physiology0.65449793
107MP0005165_increased_susceptibility_to0.64189681
108MP0003300_gastrointestinal_ulcer0.62942059
109MP0005376_homeostasis/metabolism_phenot0.60989538
110MP0002132_abnormal_respiratory_system0.60180055
111MP0000604_amyloidosis0.59991458
112MP0004883_abnormal_blood_vessel0.59882414
113MP0000920_abnormal_myelination0.59078075
114MP0005584_abnormal_enzyme/coenzyme_acti0.58842541
115MP0003566_abnormal_cell_adhesion0.58450671
116MP0002136_abnormal_kidney_physiology0.58193882
117MP0003795_abnormal_bone_structure0.57433994
118MP0004130_abnormal_muscle_cell0.56466046
119MP0004885_abnormal_endolymph0.55351230
120MP0010307_abnormal_tumor_latency0.54658558
121MP0003045_fibrosis0.54648424
122MP0005319_abnormal_enzyme/_coenzyme0.54112790
123MP0008873_increased_physiological_sensi0.53810384
124MP0002877_abnormal_melanocyte_morpholog0.53650316
125MP0002019_abnormal_tumor_incidence0.53345111
126MP0004381_abnormal_hair_follicle0.53330410
127MP0010368_abnormal_lymphatic_system0.52958911
128MP0003690_abnormal_glial_cell0.52239070
129MP0010352_gastrointestinal_tract_polyps0.51376525

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.00379058
2Eczematoid dermatitis (HP:0000976)6.61970577
3Recurrent bacterial skin infections (HP:0005406)6.45717591
4Recurrent gram-negative bacterial infections (HP:0005420)5.96939266
5Autoimmune thrombocytopenia (HP:0001973)4.94123870
6Abnormality of macrophages (HP:0004311)4.80534781
7Constricted visual fields (HP:0001133)4.54663680
8Abnormality of alanine metabolism (HP:0010916)4.51911292
9Hyperalaninemia (HP:0003348)4.51911292
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.51911292
11Systemic lupus erythematosus (HP:0002725)4.46804256
12Elevated erythrocyte sedimentation rate (HP:0003565)4.42691666
13Mediastinal lymphadenopathy (HP:0100721)4.40864629
14Recurrent skin infections (HP:0001581)4.14715528
15Myositis (HP:0100614)4.08418818
16Recurrent fungal infections (HP:0002841)4.07319144
17Anorexia (HP:0002039)4.06300196
18Pulmonary embolism (HP:0002204)3.97112046
19Orchitis (HP:0100796)3.95590468
20Increased IgM level (HP:0003496)3.94569237
21Gingivitis (HP:0000230)3.93035959
22Esophageal varix (HP:0002040)3.91094677
23Cellulitis (HP:0100658)3.69295736
24Recurrent viral infections (HP:0004429)3.53605592
25Vacuolated lymphocytes (HP:0001922)3.53335281
26Vasculitis (HP:0002633)3.52033196
27Myocardial infarction (HP:0001658)3.51137507
28Obstructive lung disease (HP:0006536)3.45020806
29Chronic obstructive pulmonary disease (HP:0006510)3.45020806
30Optic neuritis (HP:0100653)3.42355829
31Retrobulbar optic neuritis (HP:0100654)3.42355829
32Conjunctival telangiectasia (HP:0000524)3.38332141
33Abnormality of the vasculature of the conjunctiva (HP:0008054)3.31407032
34Pigmentary retinal degeneration (HP:0001146)3.30936614
35Interstitial pulmonary disease (HP:0006530)3.28421539
36Dyschromatopsia (HP:0007641)3.25043505
37Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23921556
38Congenital sensorineural hearing impairment (HP:0008527)3.21712162
39Chronic mucocutaneous candidiasis (HP:0002728)3.15623265
40Recurrent cutaneous fungal infections (HP:0011370)3.15623265
41Axonal loss (HP:0003447)3.04147539
42Meningitis (HP:0001287)3.02658421
43Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00995285
44Increased neuronal autofluorescent lipopigment (HP:0002074)3.00366219
45Thrombophlebitis (HP:0004418)2.92687903
46Increased cerebral lipofuscin (HP:0011813)2.89135333
47Glomerulonephritis (HP:0000099)2.87293113
48Recurrent pneumonia (HP:0006532)2.86350245
49Fatigue (HP:0012378)2.86270967
50Urticaria (HP:0001025)2.85629368
51Agammaglobulinemia (HP:0004432)2.81786377
52Pulmonary infiltrates (HP:0002113)2.77462843
53Basal ganglia calcification (HP:0002135)2.75945799
54Periodontitis (HP:0000704)2.74834580
55Pustule (HP:0200039)2.70724608
56Pendular nystagmus (HP:0012043)2.69605673
57Leukocytosis (HP:0001974)2.63864398
58Recurrent lower respiratory tract infections (HP:0002783)2.61037068
59Epistaxis (HP:0000421)2.57413530
60IgG deficiency (HP:0004315)2.55708653
61Abnormality of glycolipid metabolism (HP:0010969)2.55652210
62Abnormality of liposaccharide metabolism (HP:0010968)2.55652210
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.55652210
64Encephalitis (HP:0002383)2.55316681
65Granulocytopenia (HP:0001913)2.54914013
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.54283358
67Spontaneous hematomas (HP:0007420)2.53285957
68Disinhibition (HP:0000734)2.53129134
69Hypergammaglobulinemia (HP:0010702)2.53023848
70Stomatitis (HP:0010280)2.52364017
71Colitis (HP:0002583)2.52235094
72Gangrene (HP:0100758)2.51930786
73Congenital stationary night blindness (HP:0007642)2.50628565
74Chronic diarrhea (HP:0002028)2.50035835
75Osteomyelitis (HP:0002754)2.49159426
76Abnormality of T cell number (HP:0011839)2.47994120
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.46555386
78Abolished electroretinogram (ERG) (HP:0000550)2.44394766
79Abnormal rod and cone electroretinograms (HP:0008323)2.43645483
80Chest pain (HP:0100749)2.43503983
81Restrictive lung disease (HP:0002091)2.43395336
82Progressive visual loss (HP:0000529)2.42933414
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.40125116
84Petechiae (HP:0000967)2.38647993
85Thyroiditis (HP:0100646)2.36908505
86Gingival bleeding (HP:0000225)2.36856542
87White forelock (HP:0002211)2.36641975
88Combined immunodeficiency (HP:0005387)2.36565921
89Hemoptysis (HP:0002105)2.35349221
90Chronic otitis media (HP:0000389)2.32875034
91Lymphopenia (HP:0001888)2.31667473
92Inflammation of the large intestine (HP:0002037)2.30031213
93Abnormality of the nasal mucosa (HP:0000433)2.29674798
94Abnormality of the fetal cardiovascular system (HP:0010948)2.29228028
95Abnormal umbilical cord blood vessels (HP:0011403)2.29228028
96Single umbilical artery (HP:0001195)2.29228028
97Nasal polyposis (HP:0100582)2.26918697
98Abnormality of homocysteine metabolism (HP:0010919)2.26841037
99Homocystinuria (HP:0002156)2.26841037
100Arterial thrombosis (HP:0004420)2.26243393
101Recurrent bronchitis (HP:0002837)2.24919069
102IgM deficiency (HP:0002850)2.24273196
103Nausea (HP:0002018)2.22543217
104Cerebral ischemia (HP:0002637)2.20453709
105Autoimmune hemolytic anemia (HP:0001890)2.19419869
106Poor speech (HP:0002465)2.19252330
107Eosinophilia (HP:0001880)2.18719123
108Abnormality of eosinophils (HP:0001879)2.17143990
109Hematochezia (HP:0002573)2.16352140
110Hypertensive crisis (HP:0100735)2.16086507
111Gastrointestinal stroma tumor (HP:0100723)2.15761742
112Keratoconjunctivitis sicca (HP:0001097)2.14842748
113Abnormality of T cells (HP:0002843)2.14424114
114Patchy hypopigmentation of hair (HP:0011365)2.14328089
115Tetraparesis (HP:0002273)2.14128126
116Gastrointestinal inflammation (HP:0004386)2.13878992
117Chronic sinusitis (HP:0011109)2.12825643
118Thick nail (HP:0001805)2.12578707
119Purpura (HP:0000979)2.12399359
120Gastrointestinal infarctions (HP:0005244)2.10888949
121Prostate neoplasm (HP:0100787)2.10670761
122Polyneuropathy (HP:0001271)2.09671978
123Mucosal telangiectasiae (HP:0100579)2.09641473
124Sepsis (HP:0100806)2.09568114
125Chorioretinal atrophy (HP:0000533)2.09550493
126Abnormality of T cell physiology (HP:0011840)2.08944792
127Dysostosis multiplex (HP:0000943)2.08569062
128Leukopenia (HP:0001882)2.08184525
129Recurrent sinusitis (HP:0011108)2.08033170
130Microcytic anemia (HP:0001935)2.07269066
131T lymphocytopenia (HP:0005403)2.07217150
132Poor head control (HP:0002421)2.06398684
133Agnosia (HP:0010524)2.06175956
134Generalized aminoaciduria (HP:0002909)2.05520532
135Abnormality of the prostate (HP:0008775)2.04240852
136Macular degeneration (HP:0000608)2.04240393
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01543135
138Cheilitis (HP:0100825)2.01405376
139Loss of speech (HP:0002371)2.01268779
140Panhypogammaglobulinemia (HP:0003139)2.01242392
141Hypochromic anemia (HP:0001931)2.00135860
142Upper motor neuron abnormality (HP:0002127)1.97186499
143Abnormality of the pleura (HP:0002103)1.96113801
144Nephritis (HP:0000123)1.95905977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.27944017
2MAP3K33.55973152
3RIPK43.44022423
4MAP4K13.31464840
5TBK13.11760578
6BLK3.09690859
7TYK22.92842689
8ERN12.81341151
9IRAK42.73155894
10IKBKB2.60071124
11IKBKE2.49776521
12TGFBR22.41349543
13PBK2.28980050
14TXK2.25572899
15JAK32.19093919
16IRAK32.09601138
17CSF1R2.05139574
18KIT1.99267893
19PIM21.92162811
20JAK11.84712557
21CSK1.74042726
22CDK91.72506983
23ZAP701.68721672
24SYK1.67528024
25CHUK1.64848176
26ACVR1B1.64655974
27GRK11.64392784
28MAP3K131.64162846
29TESK21.51868545
30CDK121.47935089
31BTK1.40802697
32HCK1.37307583
33FGFR31.33850080
34GRK71.29396309
35PRPF4B1.28734324
36LYN1.27905426
37TEC1.25325933
38PIM11.23677696
39GRK61.21933573
40STK101.21053103
41ADRBK21.18063867
42KDR1.16544793
43LCK1.12865492
44RPS6KA41.11413559
45CDK191.08499466
46MAP3K101.07142190
47BMPR21.07032693
48MST41.05232592
49MATK1.05016104
50TNK21.04307666
51RPS6KB21.03287807
52JAK20.95657750
53CCNB10.93019902
54PASK0.90530456
55CLK10.88785758
56ABL20.88751355
57EIF2AK20.88523553
58MARK30.87959195
59STK40.87117045
60NEK90.86520646
61BMX0.85127608
62FLT30.83513494
63ITK0.83425316
64FES0.81374628
65EIF2AK30.81006775
66IRAK20.80679596
67NME20.78955501
68CAMKK20.76002347
69PRKCD0.75555913
70MST1R0.74330953
71FGR0.73665942
72NTRK20.73154319
73FGFR40.73060874
74TAOK30.72878910
75SGK4940.72588134
76SGK2230.72588134
77MAPK70.72260845
78GRK50.71317337
79ARAF0.69971535
80SIK20.68600266
81TAOK20.68421563
82SGK20.68276246
83YES10.67085405
84LRRK20.66815720
85CAMK1D0.65089120
86TIE10.63665872
87PKN20.62243865
88MAPK120.60829386
89CDK40.60499712
90EPHB10.60209421
91MOS0.59662393
92CAMKK10.58693545
93EGFR0.58402865
94MAP2K30.58110514
95ABL10.57205642
96TYRO30.55207207
97SIK10.53624239
98SIK30.51873599
99MAPKAPK20.50816335
100MAP3K110.50722541
101RIPK10.49846957
102TLK10.48405065
103PRKCQ0.48363510
104PRKG20.45208174
105SGK30.44584208
106SMG10.41955659
107IGF1R0.40859499
108STK30.40057325
109AURKA0.37814000
110ADRBK10.37327843
111PRKCH0.36625677
112STK240.36589422
113TAOK10.36207480
114PAK40.34974002
115CDC42BPA0.32790566
116MAP3K10.32326812
117RPS6KA60.31525650
118TGFBR10.30833579
119MAP3K80.29569631
120NEK60.29154053
121INSR0.28429770
122CDK60.27997535
123FYN0.27132683
124PTK60.26927548
125CSNK1A10.26182418
126ERBB30.26102209
127PAK10.25587819
128PDK10.25289488
129MAPK40.24842209
130RPS6KC10.24821703
131RPS6KL10.24821703
132TRPM70.24687993
133CAMK40.24122189
134STK110.23785520
135DYRK1B0.23610582
136IRAK10.21867593
137HIPK20.21674550

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.33070842
2Graft-versus-host disease_Homo sapiens_hsa053323.27542101
3Staphylococcus aureus infection_Homo sapiens_hsa051503.19259613
4Allograft rejection_Homo sapiens_hsa053302.72864508
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.66620731
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62052295
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53880670
8Legionellosis_Homo sapiens_hsa051342.51716340
9Osteoclast differentiation_Homo sapiens_hsa043802.35381134
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.32704122
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20687590
12Pertussis_Homo sapiens_hsa051332.18857077
13Malaria_Homo sapiens_hsa051442.17355926
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13891282
15Measles_Homo sapiens_hsa051622.11974329
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06570395
17Tuberculosis_Homo sapiens_hsa051522.02096801
18Primary immunodeficiency_Homo sapiens_hsa053401.97561973
19B cell receptor signaling pathway_Homo sapiens_hsa046621.96484547
20Rheumatoid arthritis_Homo sapiens_hsa053231.94507535
21Other glycan degradation_Homo sapiens_hsa005111.76640159
22Asthma_Homo sapiens_hsa053101.76392112
23Hematopoietic cell lineage_Homo sapiens_hsa046401.73306239
24Type I diabetes mellitus_Homo sapiens_hsa049401.71335426
25Lysosome_Homo sapiens_hsa041421.70973137
26Influenza A_Homo sapiens_hsa051641.69933100
27Herpes simplex infection_Homo sapiens_hsa051681.68475226
28TNF signaling pathway_Homo sapiens_hsa046681.67483072
29Phototransduction_Homo sapiens_hsa047441.65545508
30African trypanosomiasis_Homo sapiens_hsa051431.61411690
31Antigen processing and presentation_Homo sapiens_hsa046121.60981869
32Salmonella infection_Homo sapiens_hsa051321.59421596
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57071354
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55660813
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52322199
36Toxoplasmosis_Homo sapiens_hsa051451.49908112
37Systemic lupus erythematosus_Homo sapiens_hsa053221.48550899
38One carbon pool by folate_Homo sapiens_hsa006701.48376917
39Apoptosis_Homo sapiens_hsa042101.39003689
40* Chemokine signaling pathway_Homo sapiens_hsa040621.38819631
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.35513700
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32519029
43Phagosome_Homo sapiens_hsa041451.32293248
44Sulfur metabolism_Homo sapiens_hsa009201.31676261
45Autoimmune thyroid disease_Homo sapiens_hsa053201.27707456
46Shigellosis_Homo sapiens_hsa051311.21910355
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.18228874
48Viral myocarditis_Homo sapiens_hsa054161.17763098
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04887511
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03312905
51Hepatitis B_Homo sapiens_hsa051611.03048436
52Complement and coagulation cascades_Homo sapiens_hsa046101.00382042
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.00212514
54T cell receptor signaling pathway_Homo sapiens_hsa046600.98276765
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92660335
56Acute myeloid leukemia_Homo sapiens_hsa052210.81598826
57Sulfur relay system_Homo sapiens_hsa041220.79929344
58Hepatitis C_Homo sapiens_hsa051600.79750625
59Regulation of autophagy_Homo sapiens_hsa041400.79144110
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77222382
61Vibrio cholerae infection_Homo sapiens_hsa051100.72397922
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72080995
63Platelet activation_Homo sapiens_hsa046110.70625632
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69465320
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65212301
66Amoebiasis_Homo sapiens_hsa051460.62704801
67Prion diseases_Homo sapiens_hsa050200.61373683
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60703284
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59599330
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59080032
71Chronic myeloid leukemia_Homo sapiens_hsa052200.58317104
72Arginine biosynthesis_Homo sapiens_hsa002200.58000804
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54131561
74Oxidative phosphorylation_Homo sapiens_hsa001900.52437420
75Epstein-Barr virus infection_Homo sapiens_hsa051690.51351856
76Pancreatic cancer_Homo sapiens_hsa052120.50914198
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.50065533
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.49269310
79HIF-1 signaling pathway_Homo sapiens_hsa040660.48579656
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46005491
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40706076
82Notch signaling pathway_Homo sapiens_hsa043300.39163541
83Viral carcinogenesis_Homo sapiens_hsa052030.38335226
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37212819
85Prolactin signaling pathway_Homo sapiens_hsa049170.35847447
86HTLV-I infection_Homo sapiens_hsa051660.34271985
87Proteasome_Homo sapiens_hsa030500.32554609
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.31814162
89Arachidonic acid metabolism_Homo sapiens_hsa005900.29980700
90Small cell lung cancer_Homo sapiens_hsa052220.29367211
91Caffeine metabolism_Homo sapiens_hsa002320.29213598
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28313870
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27568485
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25472831
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24780341
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24738688
97VEGF signaling pathway_Homo sapiens_hsa043700.24213680
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22779071
99* Alcoholism_Homo sapiens_hsa050340.22511519
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.21693210
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21586313
102Vitamin digestion and absorption_Homo sapiens_hsa049770.21584033
103Insulin resistance_Homo sapiens_hsa049310.20718149
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20654852
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18917640
106* Morphine addiction_Homo sapiens_hsa050320.18576952
107Endocytosis_Homo sapiens_hsa041440.17857032
108Proteoglycans in cancer_Homo sapiens_hsa052050.17838517
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.17345530
110Selenocompound metabolism_Homo sapiens_hsa004500.17064986
111p53 signaling pathway_Homo sapiens_hsa041150.14499764
112Non-small cell lung cancer_Homo sapiens_hsa052230.14018384
113mTOR signaling pathway_Homo sapiens_hsa041500.12879791
114Synaptic vesicle cycle_Homo sapiens_hsa047210.12591540
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10585115
116Folate biosynthesis_Homo sapiens_hsa007900.09909103
117Bladder cancer_Homo sapiens_hsa052190.09258864
118Collecting duct acid secretion_Homo sapiens_hsa049660.08859205
119Ribosome_Homo sapiens_hsa030100.08127036
120Galactose metabolism_Homo sapiens_hsa000520.07384362
121FoxO signaling pathway_Homo sapiens_hsa040680.06711828
122Pentose phosphate pathway_Homo sapiens_hsa000300.06652553
123Adherens junction_Homo sapiens_hsa045200.05901432
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.04752415
125Parkinsons disease_Homo sapiens_hsa05012-0.0260750
126Ether lipid metabolism_Homo sapiens_hsa00565-0.0032185

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