GNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.80310829
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.22007647
3locomotory exploration behavior (GO:0035641)6.17308589
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47309782
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15340972
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.09837280
7glutamate secretion (GO:0014047)4.89047794
8layer formation in cerebral cortex (GO:0021819)4.81693135
9synaptic vesicle exocytosis (GO:0016079)4.77391271
10vocalization behavior (GO:0071625)4.72756157
11regulation of synaptic vesicle exocytosis (GO:2000300)4.60737358
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40710926
13sodium ion export (GO:0071436)4.40029574
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.35027461
15regulation of neuronal synaptic plasticity (GO:0048168)4.34581546
16positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.31612304
17regulation of synapse structural plasticity (GO:0051823)4.30420138
18regulation of glutamate receptor signaling pathway (GO:1900449)4.28701315
19exploration behavior (GO:0035640)4.27297677
20neurotransmitter secretion (GO:0007269)4.23888469
21positive regulation of synapse maturation (GO:0090129)4.13161144
22activation of protein kinase A activity (GO:0034199)4.07641991
23regulation of synaptic vesicle transport (GO:1902803)4.02138789
24protein retention in ER lumen (GO:0006621)4.00644378
25neuromuscular process controlling balance (GO:0050885)3.94395913
26cellular potassium ion homeostasis (GO:0030007)3.88683126
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87142373
28cerebellar granule cell differentiation (GO:0021707)3.86196703
29amino acid import (GO:0043090)3.80013823
30proline transport (GO:0015824)3.76961837
31cerebellar Purkinje cell layer development (GO:0021680)3.71024217
32regulation of translational termination (GO:0006449)3.67015075
33protein localization to synapse (GO:0035418)3.66582129
34Golgi transport vesicle coating (GO:0048200)3.64578868
35COPI coating of Golgi vesicle (GO:0048205)3.64578868
36neuromuscular process controlling posture (GO:0050884)3.63527995
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60890552
38neuronal action potential propagation (GO:0019227)3.60635934
39dendritic spine morphogenesis (GO:0060997)3.57988342
40long-term memory (GO:0007616)3.57085670
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55532356
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.54673367
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44942689
44regulation of clathrin-mediated endocytosis (GO:2000369)3.43868028
45prepulse inhibition (GO:0060134)3.38935730
46cell communication by electrical coupling (GO:0010644)3.36591241
47regulation of synaptic plasticity (GO:0048167)3.35922980
48regulation of ARF protein signal transduction (GO:0032012)3.35550480
49regulation of dendritic spine morphogenesis (GO:0061001)3.33461521
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.31299728
51positive regulation of membrane potential (GO:0045838)3.29576608
52protein localization to endosome (GO:0036010)3.23767820
53gamma-aminobutyric acid transport (GO:0015812)3.23384576
54postsynaptic membrane organization (GO:0001941)3.15158081
55L-amino acid import (GO:0043092)3.14901020
56regulation of early endosome to late endosome transport (GO:2000641)3.14770236
57vesicle transport along microtubule (GO:0047496)3.13275008
58establishment of mitochondrion localization (GO:0051654)3.12964804
59glycine transport (GO:0015816)3.12539889
60neurotransmitter transport (GO:0006836)3.09353013
61regulation of ARF GTPase activity (GO:0032312)3.08111554
62negative regulation of microtubule polymerization (GO:0031115)3.07813799
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07799948
64negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07011447
65potassium ion homeostasis (GO:0055075)3.04107390
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.03540701
67positive regulation of fibroblast migration (GO:0010763)3.02398723
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01005928
69synaptic transmission, glutamatergic (GO:0035249)3.00080101
70positive regulation of neurotransmitter transport (GO:0051590)2.99362705
71negative regulation of organelle assembly (GO:1902116)2.98627063
72adherens junction assembly (GO:0034333)2.97135409
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.96635086
74mitochondrion transport along microtubule (GO:0047497)2.96635086
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94384455
76neurotransmitter-gated ion channel clustering (GO:0072578)2.93815100
77regulation of synapse maturation (GO:0090128)2.93473125
78cell migration in hindbrain (GO:0021535)2.92355288
79regulation of neurotransmitter levels (GO:0001505)2.92167422
80peptidyl-arginine omega-N-methylation (GO:0035247)2.91542004
81regulation of NFAT protein import into nucleus (GO:0051532)2.91070244
82stress fiber assembly (GO:0043149)2.90454689
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89224530
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88699411
85synaptic vesicle endocytosis (GO:0048488)2.88664680
86peptidyl-lysine dimethylation (GO:0018027)2.86397247
87positive regulation of dendritic spine morphogenesis (GO:0061003)2.85970546
88neuromuscular process (GO:0050905)2.85259689
89regulation of postsynaptic membrane potential (GO:0060078)2.84688690
90dopamine receptor signaling pathway (GO:0007212)2.84323360
91signal complex assembly (GO:0007172)2.82138016
92cerebellar Purkinje cell differentiation (GO:0021702)2.81330790
93positive regulation of neurotransmitter secretion (GO:0001956)2.79145831
94positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.78909654
95regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.78909654
96focal adhesion assembly (GO:0048041)2.78400250
97cell-substrate adherens junction assembly (GO:0007045)2.78400250
98peptidyl-arginine N-methylation (GO:0035246)2.77438194
99peptidyl-arginine methylation (GO:0018216)2.77438194
100neuron-neuron synaptic transmission (GO:0007270)2.75504400
101positive regulation of vesicle fusion (GO:0031340)2.75222098
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73894972
103regulation of neurotransmitter secretion (GO:0046928)2.73863768
104potassium ion import (GO:0010107)2.73522884
105social behavior (GO:0035176)2.72498975
106intraspecies interaction between organisms (GO:0051703)2.72498975
107endothelial cell chemotaxis (GO:0035767)2.71854774
108positive regulation of dendritic spine development (GO:0060999)2.71822385
109protein targeting to plasma membrane (GO:0072661)2.71302821
110negative regulation of dendrite morphogenesis (GO:0050774)2.69995011
111organelle transport along microtubule (GO:0072384)2.69961919
112dendritic spine organization (GO:0097061)2.69659977
113mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.67842745
114glutamate receptor signaling pathway (GO:0007215)2.67631286
115mating behavior (GO:0007617)2.66920913
116neuronal ion channel clustering (GO:0045161)2.64885939
117negative regulation of cell size (GO:0045792)2.63753322
118adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63703346
119barbed-end actin filament capping (GO:0051016)2.63094778
120long-term synaptic potentiation (GO:0060291)2.62638636
121auditory behavior (GO:0031223)2.62222635
122semaphorin-plexin signaling pathway (GO:0071526)2.61831020
123establishment of nucleus localization (GO:0040023)2.61749235
124regulation of vesicle fusion (GO:0031338)2.61288240
125regulation of neurotransmitter transport (GO:0051588)2.59239360
126activation of MAPKKK activity (GO:0000185)2.58393134
127regulation of dendritic spine development (GO:0060998)2.58157355
128membrane depolarization during action potential (GO:0086010)2.57432024
129cellular sodium ion homeostasis (GO:0006883)2.56908532
130behavioral fear response (GO:0001662)2.56903509
131behavioral defense response (GO:0002209)2.56903509
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54522665
133cell-cell junction maintenance (GO:0045217)2.52238027
134negative regulation of catenin import into nucleus (GO:0035414)2.51962214
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.46889890
136glucocorticoid receptor signaling pathway (GO:0042921)2.42715129
137activation of Rac GTPase activity (GO:0032863)2.41460967
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41061605
139regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.34410867
140peptidyl-tyrosine autophosphorylation (GO:0038083)2.34280554
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.31126713
142regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.30766796
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30363075
144positive regulation of nuclease activity (GO:0032075)2.30164190
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29455543
146cortical actin cytoskeleton organization (GO:0030866)2.29209245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.90607906
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.56327413
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.22111706
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.19439981
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.80921211
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43454780
7LXR_22292898_ChIP-Seq_THP-1_Human2.35574388
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35169495
9KDM2B_26808549_Chip-Seq_K562_Human2.30862933
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28794664
11KDM2B_26808549_Chip-Seq_DND41_Human2.26998825
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26725399
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22352467
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.20959429
15* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.20354812
16ZNF263_19887448_ChIP-Seq_K562_Human2.19116644
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.17003383
18REST_21632747_ChIP-Seq_MESCs_Mouse2.12807805
19DROSHA_22980978_ChIP-Seq_HELA_Human2.11822627
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.07604726
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.02750454
22MYC_22102868_ChIP-Seq_BL_Human1.97492613
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.96196715
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92761047
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91859696
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86546971
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81121507
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80799376
29RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.75092849
30CLOCK_20551151_ChIP-Seq_293T_Human1.74864683
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71724870
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71724870
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70888529
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70099618
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.69564114
36TCF7_22412390_ChIP-Seq_EML_Mouse1.68516401
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67750310
38SMC4_20622854_ChIP-Seq_HELA_Human1.67159707
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65684530
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64077618
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63936224
42TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.63273208
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61258986
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60598846
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60321172
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59987848
47CREB1_26743006_Chip-Seq_LNCaP_Human1.59435554
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59145635
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58448108
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58301188
51P68_20966046_ChIP-Seq_HELA_Human1.58224370
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58136832
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58061889
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57727973
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57549171
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57425844
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54656156
58RACK7_27058665_Chip-Seq_MCF-7_Human1.52005095
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.49169934
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.46887093
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46619356
62CTCF_27219007_Chip-Seq_Bcells_Human1.41687896
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.41535288
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.41165641
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40033436
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39264109
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.38406108
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.36766454
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36157956
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.32409359
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31913125
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.31691590
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31673086
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31018370
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30209520
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28382360
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27803385
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.24462288
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24196322
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23629599
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23255239
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22829097
83* OCT4_19829295_ChIP-Seq_ESCs_Human1.22645264
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22204701
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20990498
86SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20913198
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20705924
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18858409
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17947033
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17652679
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17008667
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16408296
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15783409
94ATF3_27146783_Chip-Seq_COLON_Human1.15651709
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15576911
96KLF4_19829295_ChIP-Seq_ESCs_Human1.13637227
97VDR_21846776_ChIP-Seq_THP-1_Human1.13593134
98TP53_22127205_ChIP-Seq_IMR90_Human1.12394814
99MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10342992
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09842765
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09588323
102PHF8_20622854_ChIP-Seq_HELA_Human1.08037859
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.07986768
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.07515340
105BCOR_27268052_Chip-Seq_Bcells_Human1.06243886
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05804117
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04633371
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04371197
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.04317207
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03853670
111SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03422009
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03200682
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02855847
114* TP63_22573176_ChIP-Seq_HFKS_Human1.02355467
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02219061
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02076798
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00912251
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00780385
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00423395
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00369299
121* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99265324
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99101304
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.99072498
124SA1_27219007_Chip-Seq_Bcells_Human0.98708813
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97976193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.23409497
2MP0003635_abnormal_synaptic_transmissio4.00069967
3MP0002822_catalepsy3.69810118
4MP0002063_abnormal_learning/memory/cond3.07874677
5MP0004270_analgesia3.07708249
6MP0003880_abnormal_central_pattern2.98657914
7MP0009745_abnormal_behavioral_response2.85860522
8MP0004858_abnormal_nervous_system2.78426093
9MP0002064_seizures2.70251438
10MP0009046_muscle_twitch2.45443600
11MP0003283_abnormal_digestive_organ2.43702486
12MP0001968_abnormal_touch/_nociception2.41890818
13MP0002909_abnormal_adrenal_gland2.35948054
14MP0002572_abnormal_emotion/affect_behav2.25931758
15MP0003705_abnormal_hypodermis_morpholog2.24422733
16MP0008438_abnormal_cutaneous_collagen2.19987460
17MP0008961_abnormal_basal_metabolism2.19360398
18MP0003329_amyloid_beta_deposits2.06536212
19MP0005423_abnormal_somatic_nervous2.06472886
20MP0005623_abnormal_meninges_morphology2.05285328
21MP0004811_abnormal_neuron_physiology2.01095661
22MP0010234_abnormal_vibrissa_follicle1.88954940
23MP0005257_abnormal_intraocular_pressure1.88109250
24MP0001501_abnormal_sleep_pattern1.88018489
25MP0002734_abnormal_mechanical_nocicepti1.85825776
26MP0002272_abnormal_nervous_system1.85607539
27MP0002653_abnormal_ependyma_morphology1.85210211
28MP0001440_abnormal_grooming_behavior1.79792913
29MP0008569_lethality_at_weaning1.75345988
30MP0001486_abnormal_startle_reflex1.72296901
31MP0002733_abnormal_thermal_nociception1.66007196
32MP0002736_abnormal_nociception_after1.63765191
33MP0001502_abnormal_circadian_rhythm1.60901432
34MP0009780_abnormal_chondrocyte_physiolo1.59548071
35MP0003303_peritoneal_inflammation1.59310276
36MP0004233_abnormal_muscle_weight1.57886457
37MP0005058_abnormal_lysosome_morphology1.55057282
38MP0001970_abnormal_pain_threshold1.53850819
39MP0000751_myopathy1.52083047
40MP0003566_abnormal_cell_adhesion1.51248365
41MP0005409_darkened_coat_color1.50687745
42MP0000955_abnormal_spinal_cord1.48295000
43MP0008260_abnormal_autophagy1.48098695
44MP0004885_abnormal_endolymph1.47788768
45MP0003879_abnormal_hair_cell1.41887129
46MP0003123_paternal_imprinting1.34937603
47MP0003075_altered_response_to1.32677459
48MP0002249_abnormal_larynx_morphology1.31628090
49MP0000013_abnormal_adipose_tissue1.31459827
50MP0002184_abnormal_innervation1.30118045
51MP0003690_abnormal_glial_cell1.29761448
52MP0002557_abnormal_social/conspecific_i1.29179528
53MP0000678_abnormal_parathyroid_gland1.29119676
54MP0005167_abnormal_blood-brain_barrier1.28643253
55MP0001348_abnormal_lacrimal_gland1.26961967
56MP0001958_emphysema1.24717164
57MP0000920_abnormal_myelination1.23728088
58MP0002066_abnormal_motor_capabilities/c1.21780964
59MP0005410_abnormal_fertilization1.21070934
60MP0002067_abnormal_sensory_capabilities1.21038481
61MP0003633_abnormal_nervous_system1.17410916
62MP0005076_abnormal_cell_differentiation1.16564824
63MP0004272_abnormal_basement_membrane1.14622915
64MP0001299_abnormal_eye_distance/1.13072219
65MP0004510_myositis1.12921527
66MP0002152_abnormal_brain_morphology1.11148627
67MP0002882_abnormal_neuron_morphology1.10406527
68MP0004924_abnormal_behavior1.09896382
69MP0005386_behavior/neurological_phenoty1.09896382
70MP0003122_maternal_imprinting1.07780317
71MP0003385_abnormal_body_wall1.04943936
72MP0000747_muscle_weakness1.04067244
73MP0008874_decreased_physiological_sensi1.03336524
74MP0000579_abnormal_nail_morphology0.99386861
75MP0002089_abnormal_postnatal_growth/wei0.98340082
76MP0000733_abnormal_muscle_development0.98041232
77MP0003453_abnormal_keratinocyte_physiol0.96491882
78MP0000778_abnormal_nervous_system0.93968568
79MP0008872_abnormal_physiological_respon0.93177421
80MP0010352_gastrointestinal_tract_polyps0.90836366
81MP0002735_abnormal_chemical_nociception0.89108299
82MP0001849_ear_inflammation0.89023221
83MP0003115_abnormal_respiratory_system0.88808518
84MP0000681_abnormal_thyroid_gland0.87160616
85MP0000534_abnormal_ureter_morphology0.86378696
86MP0005503_abnormal_tendon_morphology0.86238527
87MP0003942_abnormal_urinary_system0.86061986
88MP0002060_abnormal_skin_morphology0.85739457
89MP0003631_nervous_system_phenotype0.84857982
90MP0003119_abnormal_digestive_system0.83609939
91MP0005621_abnormal_cell_physiology0.82746471
92MP0009672_abnormal_birth_weight0.82138386
93MP0000604_amyloidosis0.81988180
94MP0005375_adipose_tissue_phenotype0.81107333
95MP0008770_decreased_survivor_rate0.80608382
96MP0004145_abnormal_muscle_electrophysio0.79396897
97MP0003861_abnormal_nervous_system0.79246608
98MP0003632_abnormal_nervous_system0.78987816
99MP0003787_abnormal_imprinting0.78732480
100MP0002234_abnormal_pharynx_morphology0.77354230
101MP0002269_muscular_atrophy0.76955185
102MP0005171_absent_coat_pigmentation0.76503349
103MP0005501_abnormal_skin_physiology0.75523780
104MP0002069_abnormal_eating/drinking_beha0.75508656
105MP0001188_hyperpigmentation0.74843899
106MP0003279_aneurysm0.72722330
107MP0003091_abnormal_cell_migration0.71412629
108MP0002081_perinatal_lethality0.69515817
109MP0005666_abnormal_adipose_tissue0.69483410
110MP0000003_abnormal_adipose_tissue0.69395178
111MP0001730_embryonic_growth_arrest0.66573842
112MP0004085_abnormal_heartbeat0.65479375
113MP0004185_abnormal_adipocyte_glucose0.65072063
114MP0003634_abnormal_glial_cell0.64714555
115MP0009278_abnormal_bone_marrow0.64230357
116MP0003045_fibrosis0.63696467
117MP0003172_abnormal_lysosome_physiology0.63677051
118MP0003698_abnormal_male_reproductive0.63646586
119MP0002084_abnormal_developmental_patter0.63419875
120MP0000759_abnormal_skeletal_muscle0.62068833
121MP0005394_taste/olfaction_phenotype0.61253014
122MP0005499_abnormal_olfactory_system0.61253014
123MP0004087_abnormal_muscle_fiber0.61222686
124MP0003137_abnormal_impulse_conducting0.61192405
125MP0002877_abnormal_melanocyte_morpholog0.59461711
126MP0004142_abnormal_muscle_tone0.59366464
127MP0010769_abnormal_survival0.58994049
128MP0000537_abnormal_urethra_morphology0.56781492
129MP0005187_abnormal_penis_morphology0.56545697
130MP0010768_mortality/aging0.55464714
131MP0001177_atelectasis0.53465900
132MP0004130_abnormal_muscle_cell0.52416694
133MP0002090_abnormal_vision0.52015335

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.80996241
2Abnormality of the lower motor neuron (HP:0002366)4.82949253
3Visual hallucinations (HP:0002367)4.65578109
4Focal motor seizures (HP:0011153)4.47829194
5Focal seizures (HP:0007359)4.05398079
6Neurofibrillary tangles (HP:0002185)3.72804223
7Annular pancreas (HP:0001734)3.39540803
8Achilles tendon contracture (HP:0001771)3.34132533
9Upper limb amyotrophy (HP:0009129)3.14446282
10Distal upper limb amyotrophy (HP:0007149)3.14446282
11Ankle clonus (HP:0011448)3.07910181
12Pointed chin (HP:0000307)3.05663801
13Premature rupture of membranes (HP:0001788)3.01511232
14Peripheral hypomyelination (HP:0007182)3.01308450
15Depression (HP:0000716)2.99480093
16Abnormality of the Achilles tendon (HP:0005109)2.95863219
17Supranuclear gaze palsy (HP:0000605)2.92480691
18Insomnia (HP:0100785)2.90263891
19Dysmetric saccades (HP:0000641)2.84955387
20Atonic seizures (HP:0010819)2.82078370
21Hyperacusis (HP:0010780)2.81312096
22Cerebral aneurysm (HP:0004944)2.79907219
23Hemiplegia (HP:0002301)2.78765532
24Hand muscle atrophy (HP:0009130)2.73850611
25Impaired social interactions (HP:0000735)2.73635994
26Abnormal social behavior (HP:0012433)2.73635994
27Poor eye contact (HP:0000817)2.73588212
28Action tremor (HP:0002345)2.73061919
29Absence seizures (HP:0002121)2.70828521
30Turricephaly (HP:0000262)2.70589033
31Papilledema (HP:0001085)2.66685243
32Impaired vibration sensation in the lower limbs (HP:0002166)2.64857071
33Bundle branch block (HP:0011710)2.64758514
34Resting tremor (HP:0002322)2.64700425
35Ventricular fibrillation (HP:0001663)2.60284374
36Hypercortisolism (HP:0001578)2.53777979
37Impaired smooth pursuit (HP:0007772)2.52751696
38Difficulty climbing stairs (HP:0003551)2.52554975
39Amyotrophic lateral sclerosis (HP:0007354)2.45722280
40Hammertoe (HP:0001765)2.44584175
41Generalized tonic-clonic seizures (HP:0002069)2.44521984
42Deep palmar crease (HP:0006191)2.43682734
43Genu recurvatum (HP:0002816)2.43080249
44Ankyloglossia (HP:0010296)2.42766444
45Epileptic encephalopathy (HP:0200134)2.41799673
46Urinary urgency (HP:0000012)2.40550867
47Ulnar bowing (HP:0003031)2.39314034
48Amblyopia (HP:0000646)2.37446765
49Dialeptic seizures (HP:0011146)2.37093349
50Rapidly progressive (HP:0003678)2.35339595
51Progressive cerebellar ataxia (HP:0002073)2.33745215
52Dysdiadochokinesis (HP:0002075)2.32021788
53Distal lower limb amyotrophy (HP:0008944)2.31680310
54Megalencephaly (HP:0001355)2.28158628
55Postural instability (HP:0002172)2.27334481
56Atrophic scars (HP:0001075)2.24496775
57Abnormality of ocular smooth pursuit (HP:0000617)2.23071376
58Diplopia (HP:0000651)2.21078582
59Abnormality of binocular vision (HP:0011514)2.21078582
60Urinary bladder sphincter dysfunction (HP:0002839)2.18860152
61Neoplasm of the heart (HP:0100544)2.17180052
62Obstructive sleep apnea (HP:0002870)2.16878245
63Mutism (HP:0002300)2.16760791
64Lower limb amyotrophy (HP:0007210)2.14764589
65Protrusio acetabuli (HP:0003179)2.13100307
66Torticollis (HP:0000473)2.11203435
67Genetic anticipation (HP:0003743)2.10160958
68Long palpebral fissure (HP:0000637)2.08860181
69Vertebral compression fractures (HP:0002953)2.08435686
70Hemiparesis (HP:0001269)2.07479231
71Mitral regurgitation (HP:0001653)2.06102475
72Decreased motor nerve conduction velocity (HP:0003431)2.05690428
73Hyperparathyroidism (HP:0000843)2.02281880
74Hypoventilation (HP:0002791)2.00867453
75Shallow orbits (HP:0000586)2.00642848
76Cerebral inclusion bodies (HP:0100314)2.00154925
77Renal duplication (HP:0000075)1.99894597
78Aplasia involving bones of the upper limbs (HP:0009823)1.99662026
79Aplasia of the phalanges of the hand (HP:0009802)1.99662026
80Aplasia involving bones of the extremities (HP:0009825)1.99662026
81Fragile skin (HP:0001030)1.99169048
82Distal sensory impairment (HP:0002936)1.98980752
83Truncal ataxia (HP:0002078)1.98955320
84Bradykinesia (HP:0002067)1.98884083
85Dysmetria (HP:0001310)1.98860654
86Status epilepticus (HP:0002133)1.98701461
87Abnormal eating behavior (HP:0100738)1.98523365
88Intellectual disability, profound (HP:0002187)1.98363727
89Cholecystitis (HP:0001082)1.97888226
90Abnormal gallbladder physiology (HP:0012438)1.97888226
91Renovascular hypertension (HP:0100817)1.97035902
92Bowel incontinence (HP:0002607)1.96671985
93Febrile seizures (HP:0002373)1.96449251
94Foot dorsiflexor weakness (HP:0009027)1.95819961
95Apathy (HP:0000741)1.95704727
96Abnormality of oral frenula (HP:0000190)1.95531392
97Bowel diverticulosis (HP:0005222)1.94727321
98Abnormality of the astrocytes (HP:0100707)1.94726010
99Astrocytoma (HP:0009592)1.94726010
100Shoulder girdle muscle weakness (HP:0003547)1.94168128
101Insidious onset (HP:0003587)1.92629463
102Termporal pattern (HP:0011008)1.92629463
103Focal dystonia (HP:0004373)1.91522299
104Elfin facies (HP:0004428)1.90032700
105Spinal rigidity (HP:0003306)1.89591939
106Anxiety (HP:0000739)1.89588273
107Generalized hypotonia (HP:0001290)1.89209395
108Global brain atrophy (HP:0002283)1.88385253
109Vertebral arch anomaly (HP:0008438)1.87062576
110Vascular tortuosity (HP:0004948)1.86138453
111Neuronal loss in central nervous system (HP:0002529)1.85896385
112Arnold-Chiari malformation (HP:0002308)1.85490077
113Bronchomalacia (HP:0002780)1.85352456
114Stereotypic behavior (HP:0000733)1.84276094
115Back pain (HP:0003418)1.84101172
116Ependymoma (HP:0002888)1.83980323
117Diminished motivation (HP:0000745)1.83611160
118Abnormal large intestine physiology (HP:0012700)1.83189623
119Arterial tortuosity (HP:0005116)1.82803298
120EMG: neuropathic changes (HP:0003445)1.82150350
121Overriding aorta (HP:0002623)1.81954093
122Gaze-evoked nystagmus (HP:0000640)1.78933742
123Hyperextensible skin (HP:0000974)1.78390802
124Delusions (HP:0000746)1.78132556
125Intention tremor (HP:0002080)1.78096597
126Patellar dislocation (HP:0002999)1.77625358
127Clonus (HP:0002169)1.76522411
128Increased variability in muscle fiber diameter (HP:0003557)1.76137784
129Cerebral hypomyelination (HP:0006808)1.75827951
130Flat cornea (HP:0007720)1.75334191
131Spastic gait (HP:0002064)1.74960411
132Adenoma sebaceum (HP:0009720)1.74877736
133Angiofibromas (HP:0010615)1.74877736
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74628406
135Polygenic inheritance (HP:0010982)1.74377273
136Wormian bones (HP:0002645)1.74347711
137Difficulty running (HP:0009046)1.73437185
138Hyperthyroidism (HP:0000836)1.72321354
139Craniofacial dystonia (HP:0012179)1.71838885
140Scanning speech (HP:0002168)1.71220817
141Broad distal phalanx of finger (HP:0009836)1.70849581
142Growth hormone excess (HP:0000845)1.70254410
143Abnormality of the foot musculature (HP:0001436)1.70230049
144Truncus arteriosus (HP:0001660)1.69685253
145Increased connective tissue (HP:0009025)1.69459721
146Precocious puberty (HP:0000826)1.68604270
147Bladder diverticulum (HP:0000015)1.67786765
148Disproportionate tall stature (HP:0001519)1.66932404
149Akinesia (HP:0002304)1.65841620
150Atelectasis (HP:0100750)1.65198679
151Onion bulb formation (HP:0003383)1.64620797
152Upper limb muscle weakness (HP:0003484)1.64031659
153Biconcave vertebral bodies (HP:0004586)1.63590852
154Broad face (HP:0000283)1.62053885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.27104532
2EPHA43.51614137
3PRKD33.46773943
4TRIB33.32001857
5NTRK33.01551578
6PRPF4B2.98023642
7KSR22.80278467
8PAK62.40208229
9TAOK12.39186749
10SMG12.35765165
11DAPK22.30424668
12TYRO32.27600641
13CAMKK12.16909092
14MINK12.14366410
15PKN22.01183519
16ALK1.97368186
17STK381.85174158
18MAP3K41.84367869
19SIK11.83640620
20LATS21.83511492
21NTRK11.81360822
22NTRK21.62589177
23MARK11.44924920
24DAPK11.43571771
25NEK11.43330251
26ARAF1.42241803
27EEF2K1.40802233
28ICK1.39118145
29KSR11.38799214
30RIPK11.38450888
31IRAK31.34259369
32MAP2K41.26934181
33PDGFRA1.21542591
34SCYL21.20334487
35SIK21.19627535
36CDK51.15104313
37PNCK1.14436254
38RIPK41.13729995
39DDR21.11307975
40RAF11.09522191
41TAOK21.08742703
42GRK51.06737975
43FGFR41.04469347
44MAP3K21.01868454
45MAP3K101.01250275
46RET1.00622680
47BRAF0.99018161
48MAP3K130.97513973
49BMX0.96962766
50STK110.95562809
51TESK10.95269579
52PRKCH0.93556885
53FES0.93054783
54UHMK10.92136296
55CDK190.89347126
56CDK150.89034151
57PDK30.88969805
58PDK40.88969805
59DAPK30.85992995
60PDK10.85386932
61CDK140.84487416
62MAP3K10.84047763
63CDK11A0.82845001
64MARK20.82832298
65CDK180.82624241
66DMPK0.81572518
67PRKCG0.80020887
68MAP3K110.79738142
69NME20.79565572
70EPHA20.78283190
71PTK2B0.77554504
72PDPK10.75232673
73CAMK2B0.75192167
74EPHB10.73966368
75LMTK20.64309070
76MAPK120.63540811
77ROCK20.63195056
78IRAK20.63021086
79SGK4940.62063661
80SGK2230.62063661
81TTN0.61921554
82PINK10.61009076
83PAK30.60424606
84GRK60.60319096
85CAMK2G0.59590553
86PHKG20.59426698
87PHKG10.59426698
88WNK10.58941794
89TESK20.58886581
90MAP2K70.58673879
91CAMK10.58569900
92BRSK10.58520820
93PIM20.57731519
94CASK0.56915926
95PRKD20.55963959
96CAMKK20.54677350
97TNK20.53738804
98PTK20.53430273
99SGK30.52417356
100NEK60.52366321
101MAP2K10.52124494
102FER0.50600344
103MAP3K70.49865642
104CDC42BPA0.49802319
105DYRK1B0.49675483
106SIK30.48106125
107MAPK100.46074546
108LIMK10.46053782
109CSNK1E0.45520270
110BRD40.45335079
111HIPK20.44763938
112CDK120.44483033
113PTK60.44425274
114MOS0.44413249
115MAPK110.43457069
116CAMK40.41280090
117RPS6KA30.40117240
118NEK20.40033387
119MTOR0.38880663
120PAK20.38449989
121MAP3K80.37813143
122AURKA0.36927010
123ERN10.36846160
124AKT20.36603431
125LRRK20.36423217
126MET0.34749153
127PAK40.34681392
128FGFR10.32988673
129PLK20.31888963
130PRKCZ0.31471482
131ILK0.29804848
132RPS6KA20.29490643
133PAK10.28608505

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.83266123
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.66679798
3Olfactory transduction_Homo sapiens_hsa047402.50822408
4Long-term potentiation_Homo sapiens_hsa047202.43641400
5Amphetamine addiction_Homo sapiens_hsa050312.10316396
6Nicotine addiction_Homo sapiens_hsa050332.03577407
7Circadian entrainment_Homo sapiens_hsa047132.01355426
8GABAergic synapse_Homo sapiens_hsa047271.94152849
9Dopaminergic synapse_Homo sapiens_hsa047281.85651993
10Glutamatergic synapse_Homo sapiens_hsa047241.82109983
11Gastric acid secretion_Homo sapiens_hsa049711.76479373
12Morphine addiction_Homo sapiens_hsa050321.73714991
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71751848
14Salivary secretion_Homo sapiens_hsa049701.68952303
15Insulin secretion_Homo sapiens_hsa049111.65216517
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65009703
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63171190
18Nitrogen metabolism_Homo sapiens_hsa009101.63036604
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62219255
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60368465
21Glioma_Homo sapiens_hsa052141.58817544
22GnRH signaling pathway_Homo sapiens_hsa049121.58319962
23Cholinergic synapse_Homo sapiens_hsa047251.58188676
24Estrogen signaling pathway_Homo sapiens_hsa049151.56784995
25Oxytocin signaling pathway_Homo sapiens_hsa049211.56447301
26Cocaine addiction_Homo sapiens_hsa050301.55127675
27Gap junction_Homo sapiens_hsa045401.41629077
28VEGF signaling pathway_Homo sapiens_hsa043701.34605809
29Oocyte meiosis_Homo sapiens_hsa041141.34151025
30Long-term depression_Homo sapiens_hsa047301.30995831
31Renin secretion_Homo sapiens_hsa049241.30970535
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29820536
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25615391
34mTOR signaling pathway_Homo sapiens_hsa041501.22558151
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20287084
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.18878240
37Vibrio cholerae infection_Homo sapiens_hsa051101.16245583
38Type II diabetes mellitus_Homo sapiens_hsa049301.16139609
39Dorso-ventral axis formation_Homo sapiens_hsa043201.14259477
40ErbB signaling pathway_Homo sapiens_hsa040121.13719728
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13238186
42Melanogenesis_Homo sapiens_hsa049161.12404625
43Calcium signaling pathway_Homo sapiens_hsa040201.10670478
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08537474
45Pancreatic cancer_Homo sapiens_hsa052121.08428075
46Notch signaling pathway_Homo sapiens_hsa043301.08352253
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.08080145
48cAMP signaling pathway_Homo sapiens_hsa040241.06562225
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05326799
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03342421
51Taste transduction_Homo sapiens_hsa047421.01071192
52Non-small cell lung cancer_Homo sapiens_hsa052230.99653310
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99412207
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.98732819
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93928634
56Vitamin B6 metabolism_Homo sapiens_hsa007500.93088252
57Focal adhesion_Homo sapiens_hsa045100.91298197
58Endocytosis_Homo sapiens_hsa041440.90136973
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89121829
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87165744
61Endometrial cancer_Homo sapiens_hsa052130.84807716
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84365654
63AMPK signaling pathway_Homo sapiens_hsa041520.84150719
64Glucagon signaling pathway_Homo sapiens_hsa049220.84043298
65MAPK signaling pathway_Homo sapiens_hsa040100.83835605
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83569879
67Adherens junction_Homo sapiens_hsa045200.80399369
68Chronic myeloid leukemia_Homo sapiens_hsa052200.80158582
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79377929
70MicroRNAs in cancer_Homo sapiens_hsa052060.78749880
71Choline metabolism in cancer_Homo sapiens_hsa052310.78724322
72Bladder cancer_Homo sapiens_hsa052190.78425981
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.78382105
74Insulin signaling pathway_Homo sapiens_hsa049100.78298269
75Renal cell carcinoma_Homo sapiens_hsa052110.77542483
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77464072
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77118907
78Rap1 signaling pathway_Homo sapiens_hsa040150.75995660
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75939167
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74996184
81Fructose and mannose metabolism_Homo sapiens_hsa000510.74803727
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74229673
83Serotonergic synapse_Homo sapiens_hsa047260.73306479
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72742935
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71646733
86mRNA surveillance pathway_Homo sapiens_hsa030150.71316173
87Dilated cardiomyopathy_Homo sapiens_hsa054140.70847213
88Thyroid hormone synthesis_Homo sapiens_hsa049180.70064454
89Pentose phosphate pathway_Homo sapiens_hsa000300.69651032
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67916960
91Thyroid cancer_Homo sapiens_hsa052160.66324195
92Other glycan degradation_Homo sapiens_hsa005110.65276538
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.64365914
94Axon guidance_Homo sapiens_hsa043600.64203488
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63802187
96Prolactin signaling pathway_Homo sapiens_hsa049170.62462052
97HIF-1 signaling pathway_Homo sapiens_hsa040660.61687739
98Prion diseases_Homo sapiens_hsa050200.61475231
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61274421
100Sulfur relay system_Homo sapiens_hsa041220.61141868
101Proteoglycans in cancer_Homo sapiens_hsa052050.60559091
102Colorectal cancer_Homo sapiens_hsa052100.59753666
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59404243
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58187712
105Hippo signaling pathway_Homo sapiens_hsa043900.58077043
106B cell receptor signaling pathway_Homo sapiens_hsa046620.57224819
107Prostate cancer_Homo sapiens_hsa052150.56924186
108ECM-receptor interaction_Homo sapiens_hsa045120.56768424
109Wnt signaling pathway_Homo sapiens_hsa043100.55826487
110Cardiac muscle contraction_Homo sapiens_hsa042600.54155732
111Pancreatic secretion_Homo sapiens_hsa049720.53175911
112Ras signaling pathway_Homo sapiens_hsa040140.52853715
113Tight junction_Homo sapiens_hsa045300.52261761
114Alcoholism_Homo sapiens_hsa050340.51167592
115Inositol phosphate metabolism_Homo sapiens_hsa005620.50257554
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.50048342
117Acute myeloid leukemia_Homo sapiens_hsa052210.47701670
118Bile secretion_Homo sapiens_hsa049760.45826742
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45691055
120Hedgehog signaling pathway_Homo sapiens_hsa043400.43542076
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43393541
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42002940

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