ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.22100222
2	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	4.88530733
3	regulation of cilium movement (GO:0003352)	4.67452481
4	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.48051668
5	somite development (GO:0061053)	4.36087524
6	regulation of mitochondrial translation (GO:0070129)	4.21195812
7	positive regulation of cell size (GO:0045793)	4.01324477
8	ribonucleoprotein complex disassembly (GO:0032988)	3.84705746
9	L-serine metabolic process (GO:0006563)	3.54298146
10	striatum development (GO:0021756)	3.52118856
11	replication fork processing (GO:0031297)	3.51069369
12	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.48742673
13	cullin deneddylation (GO:0010388)	3.46103694
14	nonmotile primary cilium assembly (GO:0035058)	3.43200658
15	DNA strand renaturation (GO:0000733)	3.41516045
16	negative regulation of execution phase of apoptosis (GO:1900118)	3.36108691
17	negative regulation of telomere maintenance (GO:0032205)	3.29383940
18	ribosomal large subunit biogenesis (GO:0042273)	3.26791927
19	telomere maintenance via telomerase (GO:0007004)	3.24078597
20	organelle disassembly (GO:1903008)	3.19493532
21	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.14518674
22	chromatin remodeling at centromere (GO:0031055)	3.12907983
23	CENP-A containing nucleosome assembly (GO:0034080)	3.12559820
24	nuclear pore organization (GO:0006999)	3.10949522
25	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.09332496
26	maturation of 5.8S rRNA (GO:0000460)	3.02894844
27	protein deneddylation (GO:0000338)	3.01320380
28	mitotic nuclear envelope disassembly (GO:0007077)	2.97794604
29	DNA replication checkpoint (GO:0000076)	2.97063461
30	maturation of SSU-rRNA (GO:0030490)	2.94483317
31	response to pheromone (GO:0019236)	2.89449365
32	formation of translation preinitiation complex (GO:0001731)	2.88268915
33	regulation of microtubule-based movement (GO:0060632)	2.87922187
34	tachykinin receptor signaling pathway (GO:0007217)	2.86434783
35	olfactory bulb development (GO:0021772)	2.84834613
36	purine nucleobase biosynthetic process (GO:0009113)	2.79221081
37	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.79100671
38	regulation of DNA-dependent DNA replication (GO:0090329)	2.77544475
39	positive regulation of receptor biosynthetic process (GO:0010870)	2.72529963
40	DNA replication-dependent nucleosome assembly (GO:0006335)	2.72173186
41	DNA replication-dependent nucleosome organization (GO:0034723)	2.72173186
42	resolution of meiotic recombination intermediates (GO:0000712)	2.70798719
43	DNA replication-independent nucleosome assembly (GO:0006336)	2.69049863
44	DNA replication-independent nucleosome organization (GO:0034724)	2.69049863
45	positive regulation of mitochondrial fission (GO:0090141)	2.68375231
46	DNA ligation (GO:0006266)	2.67469101
47	nuclear pore complex assembly (GO:0051292)	2.66657792
48	histone exchange (GO:0043486)	2.66184858
49	IMP biosynthetic process (GO:0006188)	2.64789960
50	regulation of DNA endoreduplication (GO:0032875)	2.63212859
51	branched-chain amino acid catabolic process (GO:0009083)	2.58852613
52	membrane disassembly (GO:0030397)	2.58196520
53	nuclear envelope disassembly (GO:0051081)	2.58196520
54	pyrimidine nucleobase catabolic process (GO:0006208)	2.57485964
55	regulation of neurotransmitter uptake (GO:0051580)	2.56920131
56	negative regulation of DNA recombination (GO:0045910)	2.55115295
57	DNA catabolic process, exonucleolytic (GO:0000738)	2.54116701
58	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.54088719
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.54000528
60	nucleobase biosynthetic process (GO:0046112)	2.52999056
61	amino acid activation (GO:0043038)	2.52798514
62	tRNA aminoacylation (GO:0043039)	2.52798514
63	negative regulation of appetite (GO:0032099)	2.51887593
64	negative regulation of response to food (GO:0032096)	2.51887593
65	RNA-dependent DNA replication (GO:0006278)	2.51461779
66	protein localization to kinetochore (GO:0034501)	2.48819968
67	heterochromatin organization (GO:0070828)	2.48359905
68	tRNA aminoacylation for protein translation (GO:0006418)	2.47849769
69	telomere maintenance via telomere lengthening (GO:0010833)	2.47642014
70	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.46614196
71	peptidyl-cysteine modification (GO:0018198)	2.45990480
72	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.45609067
73	DNA excision (GO:0044349)	2.45609067
74	reciprocal DNA recombination (GO:0035825)	2.44104008
75	reciprocal meiotic recombination (GO:0007131)	2.44104008
76	negative regulation of vascular permeability (GO:0043116)	2.43752590
77	regulation of mitotic spindle checkpoint (GO:1903504)	2.43725951
78	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.43725951
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.42278836
80	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.42278836
81	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.42278836
82	folic acid metabolic process (GO:0046655)	2.41255434
83	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40399362
84	transcription-coupled nucleotide-excision repair (GO:0006283)	2.39736603
85	cellular response to leptin stimulus (GO:0044320)	2.39583413
86	adenine nucleotide transport (GO:0051503)	2.39521770
87	regulation of appetite (GO:0032098)	2.38664261
88	termination of RNA polymerase I transcription (GO:0006363)	2.38249853
89	regulation of stem cell maintenance (GO:2000036)	2.37789264
90	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.37711397
91	UMP metabolic process (GO:0046049)	2.37711397
92	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.37711397
93	UMP biosynthetic process (GO:0006222)	2.37711397
94	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.36518754
95	fatty acid elongation (GO:0030497)	2.36258311
96	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.36140623
97	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.36140623
98	regulation of translation, ncRNA-mediated (GO:0045974)	2.36140623
99	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.35382266
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.35382266

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.88286907
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	5.78712538
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57523010
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.56056340
5	VDR_22108803_ChIP-Seq_LS180_Human	3.45565719
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.07823001
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.96512272
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94690500
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.93285523
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86669052
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.77433015
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.77355005
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53210003
14	FUS_26573619_Chip-Seq_HEK293_Human	2.51535137
15	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.50757754
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.47304944
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33301754
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.25304944
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.19034933
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.17535961
21	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.16862002
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16270207
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11020427
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97626051
25	EWS_26573619_Chip-Seq_HEK293_Human	1.95420243
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.94590618
27	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.90591631
28	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.88304600
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84519982
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.72230774
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.70226724
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68752564
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.66432429
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.59105636
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58241510
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.57129570
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53564119
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51405800
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50324943
40	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.48339977
41	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.47809179
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46136067
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.43731178
44	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.41336820
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36927547
46	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34735021
47	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.34406884
48	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.34041878
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.33718019
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.32030974
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31833957
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31050761
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29556213
54	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.29458520
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.24664228
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21914705
57	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.21166112
58	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20638024
59	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19870069
60	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.19514724
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18877625
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17882642
63	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.13727180
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13351596
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.09776357
66	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.08490123
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07127291
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06107531
69	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05708091
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03656962
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.03085411
72	P300_19829295_ChIP-Seq_ESCs_Human	1.02930516
73	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96685630
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96291665
75	TP53_22573176_ChIP-Seq_HFKS_Human	0.94982958
76	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.93815020
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.93597895
78	AR_21909140_ChIP-Seq_LNCAP_Human	0.93399952
79	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93219907
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90969240
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90111313
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.88352562
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88160497
84	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88160497
85	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.88042757
86	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.86977225
87	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.86396312
88	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86218142
89	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85563941
90	GATA1_22025678_ChIP-Seq_K562_Human	0.85230999
91	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.84835982
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84609110
93	CBP_20019798_ChIP-Seq_JUKART_Human	0.81872879
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.81872879
95	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.80851797
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.78662954
97	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.78489811
98	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.77422108
99	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.76686593
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.75729910

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	5.80849732
2	MP0008058_abnormal_DNA_repair	4.02862780
3	MP0003880_abnormal_central_pattern	3.27719203
4	MP0002736_abnormal_nociception_after	2.89077440
5	MP0002938_white_spotting	2.77264142
6	MP0003136_yellow_coat_color	2.42735154
7	MP0002234_abnormal_pharynx_morphology	2.37330362
8	MP0010094_abnormal_chromosome_stability	2.34061446
9	MP0008789_abnormal_olfactory_epithelium	2.20239133
10	MP0010030_abnormal_orbit_morphology	2.16591877
11	MP0000372_irregular_coat_pigmentation	2.13253216
12	MP0001529_abnormal_vocalization	2.11622004
13	MP0003693_abnormal_embryo_hatching	2.08627932
14	MP0008877_abnormal_DNA_methylation	2.06050248
15	MP0008995_early_reproductive_senescence	2.01342638
16	MP0005394_taste/olfaction_phenotype	1.96218657
17	MP0005499_abnormal_olfactory_system	1.96218657
18	MP0009053_abnormal_anal_canal	1.91290478
19	MP0002233_abnormal_nose_morphology	1.89545580
20	MP0006292_abnormal_olfactory_placode	1.89458345
21	MP0004957_abnormal_blastocyst_morpholog	1.78977491
22	MP0003646_muscle_fatigue	1.78965995
23	MP0001984_abnormal_olfaction	1.77505562
24	MP0005423_abnormal_somatic_nervous	1.77374467
25	MP0001968_abnormal_touch/_nociception	1.70766501
26	MP0000537_abnormal_urethra_morphology	1.69591536
27	MP0003937_abnormal_limbs/digits/tail_de	1.66073859
28	MP0001293_anophthalmia	1.65417657
29	MP0003077_abnormal_cell_cycle	1.62473349
30	MP0000778_abnormal_nervous_system	1.57863262
31	MP0002277_abnormal_respiratory_mucosa	1.52510540
32	MP0004233_abnormal_muscle_weight	1.51773379
33	MP0000516_abnormal_urinary_system	1.51467226
34	MP0005367_renal/urinary_system_phenotyp	1.51467226
35	MP0003938_abnormal_ear_development	1.48604716
36	MP0003718_maternal_effect	1.39186461
37	MP0003111_abnormal_nucleus_morphology	1.33744045
38	MP0008932_abnormal_embryonic_tissue	1.31236873
39	MP0001764_abnormal_homeostasis	1.26681147
40	MP0008057_abnormal_DNA_replication	1.25903303
41	MP0002127_abnormal_cardiovascular_syste	1.22658530
42	MP0006035_abnormal_mitochondrial_morpho	1.13197240
43	MP0002735_abnormal_chemical_nociception	1.13070438
44	MP0006072_abnormal_retinal_apoptosis	1.12945709
45	MP0000631_abnormal_neuroendocrine_gland	1.12486629
46	MP0000579_abnormal_nail_morphology	1.11812360
47	MP0008007_abnormal_cellular_replicative	1.11202059
48	MP0006276_abnormal_autonomic_nervous	1.11163784
49	MP0008872_abnormal_physiological_respon	1.10265254
50	MP0002751_abnormal_autonomic_nervous	1.10252311
51	MP0003890_abnormal_embryonic-extraembry	1.08059982
52	MP0002184_abnormal_innervation	1.07358771
53	MP0002084_abnormal_developmental_patter	1.05869963
54	MP0002111_abnormal_tail_morphology	1.05544642
55	MP0001697_abnormal_embryo_size	1.04851440
56	MP0002822_catalepsy	1.04830887
57	MP0001286_abnormal_eye_development	1.04223088
58	MP0003755_abnormal_palate_morphology	1.03385296
59	MP0005645_abnormal_hypothalamus_physiol	1.03249799
60	MP0003786_premature_aging	1.00837398
61	MP0003221_abnormal_cardiomyocyte_apopto	0.99745851
62	MP0003119_abnormal_digestive_system	0.99367803
63	MP0009379_abnormal_foot_pigmentation	0.97015911
64	MP0009703_decreased_birth_body	0.96690271
65	MP0008775_abnormal_heart_ventricle	0.95557582
66	MP0001672_abnormal_embryogenesis/_devel	0.93411533
67	MP0005380_embryogenesis_phenotype	0.93411533
68	MP0003567_abnormal_fetal_cardiomyocyte	0.93391954
69	MP0004133_heterotaxia	0.92638396
70	MP0003861_abnormal_nervous_system	0.90840213
71	MP0000467_abnormal_esophagus_morphology	0.90037145
72	MP0001929_abnormal_gametogenesis	0.89013743
73	MP0002734_abnormal_mechanical_nocicepti	0.88863808
74	MP0002088_abnormal_embryonic_growth/wei	0.86466530
75	MP0002697_abnormal_eye_size	0.85761936
76	MP0002210_abnormal_sex_determination	0.84725955
77	MP0002572_abnormal_emotion/affect_behav	0.84285718
78	MP0002085_abnormal_embryonic_tissue	0.84274646
79	MP0003935_abnormal_craniofacial_develop	0.84249298
80	MP0003984_embryonic_growth_retardation	0.84218450
81	MP0003315_abnormal_perineum_morphology	0.83817251
82	MP0005167_abnormal_blood-brain_barrier	0.83639285
83	MP0010368_abnormal_lymphatic_system	0.82761030
84	MP0009672_abnormal_birth_weight	0.81837981
85	MP0000049_abnormal_middle_ear	0.81224976
86	MP0001485_abnormal_pinna_reflex	0.81154144
87	MP0000383_abnormal_hair_follicle	0.80715849
88	MP0004043_abnormal_pH_regulation	0.79726850
89	MP0001145_abnormal_male_reproductive	0.79540587
90	MP0002109_abnormal_limb_morphology	0.79310093
91	MP0009697_abnormal_copulation	0.79266319
92	MP0002272_abnormal_nervous_system	0.79003159
93	MP0000647_abnormal_sebaceous_gland	0.77611371
94	MP0005551_abnormal_eye_electrophysiolog	0.73588017
95	MP0004811_abnormal_neuron_physiology	0.73458158
96	MP0000653_abnormal_sex_gland	0.73064751
97	MP0002282_abnormal_trachea_morphology	0.72466664
98	MP0000350_abnormal_cell_proliferation	0.71318283
99	MP0003698_abnormal_male_reproductive	0.70775456
100	MP0010307_abnormal_tumor_latency	0.70196311

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.47446896
2	Reticulocytopenia (HP:0001896)	3.42179774
3	Esophageal atresia (HP:0002032)	3.13971464
4	Gait imbalance (HP:0002141)	3.06040562
5	Abnormality of chromosome stability (HP:0003220)	3.05792132
6	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.05396618
7	Abnormality of the labia minora (HP:0012880)	3.04244709
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.98078224
9	Meckel diverticulum (HP:0002245)	2.97343648
10	Congenital primary aphakia (HP:0007707)	2.93109828
11	Spastic diplegia (HP:0001264)	2.88490687
12	Absent thumb (HP:0009777)	2.86902734
13	Anal stenosis (HP:0002025)	2.82467858
14	Medial flaring of the eyebrow (HP:0010747)	2.76616414
15	Abnormality of the ileum (HP:0001549)	2.75178035
16	Stenosis of the external auditory canal (HP:0000402)	2.73876545
17	Nephrogenic diabetes insipidus (HP:0009806)	2.73766392
18	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.63573677
19	Vertebral hypoplasia (HP:0008417)	2.63573677
20	Ectopic kidney (HP:0000086)	2.53928040
21	Pancreatic cysts (HP:0001737)	2.50853941
22	Abnormality of the carotid arteries (HP:0005344)	2.50222134
23	Cortical dysplasia (HP:0002539)	2.49264228
24	Septo-optic dysplasia (HP:0100842)	2.41101544
25	Gonadotropin excess (HP:0000837)	2.40662193
26	Vaginal atresia (HP:0000148)	2.39290482
27	Preaxial foot polydactyly (HP:0001841)	2.39038988
28	Hypoplastic pelvis (HP:0008839)	2.38128804
29	Overriding aorta (HP:0002623)	2.35386042
30	Triphalangeal thumb (HP:0001199)	2.34399752
31	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.34025316
32	Trigonocephaly (HP:0000243)	2.27823116
33	Duplication of thumb phalanx (HP:0009942)	2.27165713
34	Abnormality of the preputium (HP:0100587)	2.26073368
35	Microvesicular hepatic steatosis (HP:0001414)	2.25804454
36	Sparse lateral eyebrow (HP:0005338)	2.22041498
37	Genital tract atresia (HP:0001827)	2.21905623
38	Poor coordination (HP:0002370)	2.19671229
39	Absent radius (HP:0003974)	2.19527739
40	Aplasia involving forearm bones (HP:0009822)	2.17117211
41	Absent forearm bone (HP:0003953)	2.17117211
42	Lower limb hyperreflexia (HP:0002395)	2.16660069
43	Posterior subcapsular cataract (HP:0007787)	2.16365903
44	Sensory axonal neuropathy (HP:0003390)	2.14372652
45	Abnormality of serum amino acid levels (HP:0003112)	2.13115337
46	Short 5th finger (HP:0009237)	2.13115088
47	Cerebral hypomyelination (HP:0006808)	2.12822438
48	Absent septum pellucidum (HP:0001331)	2.12099417
49	Hyperglycinemia (HP:0002154)	2.11845479
50	Abnormality of glycolysis (HP:0004366)	2.11305127
51	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10598971
52	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.10007157
53	Supernumerary spleens (HP:0009799)	2.09853642
54	Abnormality of the diencephalon (HP:0010662)	2.09439189
55	Atonic seizures (HP:0010819)	2.08840219
56	Abnormality of methionine metabolism (HP:0010901)	2.07169542
57	Hypoplastic labia majora (HP:0000059)	2.06441360
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06150453
59	Abnormality of alanine metabolism (HP:0010916)	2.06150453
60	Hyperalaninemia (HP:0003348)	2.06150453
61	Abnormality of cochlea (HP:0000375)	2.03942776
62	Pancreatic fibrosis (HP:0100732)	2.02032605
63	Hemivertebrae (HP:0002937)	1.99956084
64	Increased nuchal translucency (HP:0010880)	1.98961009
65	Pheochromocytoma (HP:0002666)	1.97160226
66	Abnormality of the septum pellucidum (HP:0007375)	1.95645780
67	Labial hypoplasia (HP:0000066)	1.92039455
68	Thyroid-stimulating hormone excess (HP:0002925)	1.91699837
69	Fibular aplasia (HP:0002990)	1.91563725
70	Broad foot (HP:0001769)	1.90342679
71	Capillary hemangiomas (HP:0005306)	1.89154252
72	Sclerocornea (HP:0000647)	1.86686086
73	Preaxial hand polydactyly (HP:0001177)	1.86262048
74	Exercise-induced muscle cramps (HP:0003710)	1.86035547
75	Birth length less than 3rd percentile (HP:0003561)	1.85902361
76	Small intestinal stenosis (HP:0012848)	1.85342919
77	Duodenal stenosis (HP:0100867)	1.85342919
78	Intellectual disability, moderate (HP:0002342)	1.83340779
79	Facial cleft (HP:0002006)	1.83066563
80	Hypoplastic female external genitalia (HP:0012815)	1.82426633
81	Abnormality of the labia majora (HP:0012881)	1.81405363
82	Astigmatism (HP:0000483)	1.81326973
83	Concave nail (HP:0001598)	1.79442910
84	Micropenis (HP:0000054)	1.79270007
85	Intestinal fistula (HP:0100819)	1.79081164
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77803251
87	Increased serum pyruvate (HP:0003542)	1.77418117
88	Depressed nasal tip (HP:0000437)	1.77180399
89	Gastrointestinal atresia (HP:0002589)	1.76925875
90	True hermaphroditism (HP:0010459)	1.76538334
91	Abolished electroretinogram (ERG) (HP:0000550)	1.76428493
92	Rib fusion (HP:0000902)	1.76323348
93	Abnormality of the duodenum (HP:0002246)	1.76280599
94	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.72832566
95	CNS hypomyelination (HP:0003429)	1.72747735
96	Synostosis involving the elbow (HP:0003938)	1.72692444
97	Humeroradial synostosis (HP:0003041)	1.72692444
98	Microglossia (HP:0000171)	1.71709359
99	Neuroendocrine neoplasm (HP:0100634)	1.70830349
100	Pendular nystagmus (HP:0012043)	1.70261395

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	3.65065558
2	SRPK1	3.59142135
3	WNK4	3.35893951
4	STK24	3.33802324
5	ZAK	3.31642074
6	STK39	3.15850027
7	PDK2	3.00506025
8	PINK1	2.39974407
9	WEE1	2.33204937
10	MAP3K2	2.25214310
11	CCNB1	2.24417596
12	TTK	2.23034141
13	TSSK6	2.18986517
14	MAP3K12	2.14083096
15	EIF2AK3	1.98373883
16	BUB1	1.97373243
17	CASK	1.83630708
18	BRSK2	1.82147107
19	BCKDK	1.80855875
20	CDC7	1.80807512
21	MKNK1	1.75333384
22	NEK1	1.66982042
23	EIF2AK1	1.64543369
24	STK38L	1.51375256
25	TNIK	1.48621554
26	PBK	1.46718996
27	TRIM28	1.44822212
28	CHEK2	1.39616533
29	PLK3	1.38658684
30	MAP3K4	1.31460454
31	MKNK2	1.30860237
32	WNK3	1.21407606
33	PASK	1.18586558
34	BCR	1.18447908
35	WNK1	1.15857019
36	EIF2AK2	1.10971667
37	MAPK13	1.06600236
38	MAPKAPK3	1.03728298
39	CSNK1G1	1.03675759
40	CSNK1A1L	1.03255748
41	CSNK1G3	1.01325389
42	DYRK3	1.01158167
43	PAK3	1.00921168
44	PLK1	1.00895126
45	DYRK2	0.98483936
46	RPS6KA4	0.98282969
47	MINK1	0.96816485
48	CAMK1	0.94557092
49	ATR	0.92367804
50	CDK8	0.91629545
51	VRK2	0.84984811
52	MAP4K2	0.81835607
53	CSNK1G2	0.77702318
54	MAP3K9	0.76117920
55	FGFR2	0.75726611
56	AURKB	0.73797968
57	ATM	0.70385925
58	CLK1	0.70347654
59	CHEK1	0.68028482
60	PNCK	0.67826640
61	CSNK1E	0.61885156
62	NEK2	0.61152308
63	BRSK1	0.60581930
64	STK16	0.59591699
65	PLK4	0.58661275
66	BMPR1B	0.57637098
67	PLK2	0.55875351
68	NEK6	0.55236317
69	MAP2K7	0.54700980
70	FGFR1	0.54444327
71	PRKCE	0.53892307
72	NTRK2	0.52863925
73	CSNK2A2	0.51107009
74	MAP2K4	0.50921710
75	CSNK2A1	0.48454086
76	ERBB3	0.48256385
77	MARK1	0.47015050
78	MST4	0.46790439
79	KSR1	0.46659558
80	MAP3K3	0.45997058
81	ILK	0.43996066
82	EEF2K	0.42938372
83	PRKCG	0.39073266
84	CDK2	0.38936638
85	FLT3	0.38109804
86	TGFBR1	0.36674108
87	AKT3	0.35559252
88	PAK2	0.34636881
89	EPHA2	0.33710722
90	EGFR	0.33537279
91	CDK7	0.32511525
92	CDK9	0.31469975
93	FRK	0.31351230
94	STK3	0.31250973
95	CDK1	0.30338806
96	RPS6KB2	0.30293541
97	TEC	0.29296483
98	NEK9	0.29158956
99	CAMK4	0.28557134
100	PRKDC	0.26798562

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.25874142
2	Proteasome_Homo sapiens_hsa03050	3.11299599
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.82767579
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.71621296
5	Homologous recombination_Homo sapiens_hsa03440	2.58732269
6	RNA transport_Homo sapiens_hsa03013	2.58586439
7	Nucleotide excision repair_Homo sapiens_hsa03420	2.56654517
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45033952
9	Base excision repair_Homo sapiens_hsa03410	2.40856688
10	Basal transcription factors_Homo sapiens_hsa03022	2.40412408
11	DNA replication_Homo sapiens_hsa03030	2.31846033
12	RNA degradation_Homo sapiens_hsa03018	2.26528563
13	One carbon pool by folate_Homo sapiens_hsa00670	2.14228304
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.08839554
15	Propanoate metabolism_Homo sapiens_hsa00640	2.08262607
16	Protein export_Homo sapiens_hsa03060	2.07460093
17	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05938086
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.03981330
19	Mismatch repair_Homo sapiens_hsa03430	1.94834191
20	Fatty acid elongation_Homo sapiens_hsa00062	1.82739155
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75407137
22	Spliceosome_Homo sapiens_hsa03040	1.72120443
23	RNA polymerase_Homo sapiens_hsa03020	1.70068281
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68422214
25	Ribosome_Homo sapiens_hsa03010	1.68147826
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.64830550
27	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.59219079
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.58324868
29	Phototransduction_Homo sapiens_hsa04744	1.56815844
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.42096418
31	Parkinsons disease_Homo sapiens_hsa05012	1.39304635
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35340422
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34175110
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.33817224
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.33359254
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22384980
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22052458
38	Arginine biosynthesis_Homo sapiens_hsa00220	1.18558245
39	Cell cycle_Homo sapiens_hsa04110	1.16803202
40	Carbon metabolism_Homo sapiens_hsa01200	1.15755756
41	Huntingtons disease_Homo sapiens_hsa05016	1.10637047
42	Butanoate metabolism_Homo sapiens_hsa00650	1.09518499
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.09368404
44	Lysine degradation_Homo sapiens_hsa00310	1.05803683
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04500189
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01069848
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98683827
48	Alzheimers disease_Homo sapiens_hsa05010	0.93865744
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89991481
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87973848
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86586178
52	Purine metabolism_Homo sapiens_hsa00230	0.78165485
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77105945
54	Taste transduction_Homo sapiens_hsa04742	0.76450646
55	Oocyte meiosis_Homo sapiens_hsa04114	0.72641030
56	Sulfur relay system_Homo sapiens_hsa04122	0.70589582
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.70393931
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67117274
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67043610
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65366359
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.65239225
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64612428
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.61972575
64	Metabolic pathways_Homo sapiens_hsa01100	0.61771491
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59860951
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.58289624
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55350253
68	Peroxisome_Homo sapiens_hsa04146	0.54101632
69	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53393970
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51880899
71	Olfactory transduction_Homo sapiens_hsa04740	0.51392779
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51195889
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.49986865
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49295958
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47220054
76	Sulfur metabolism_Homo sapiens_hsa00920	0.46780394
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.46392200
78	Glutathione metabolism_Homo sapiens_hsa00480	0.42506611
79	Pentose phosphate pathway_Homo sapiens_hsa00030	0.41360726
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41279412
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.37927928
82	Nicotine addiction_Homo sapiens_hsa05033	0.37242637
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36576281
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36444981
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33012346
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.28605262
87	Cardiac muscle contraction_Homo sapiens_hsa04260	0.27291060
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.27201529
89	Amphetamine addiction_Homo sapiens_hsa05031	0.26458170
90	Galactose metabolism_Homo sapiens_hsa00052	0.26336371
91	Circadian rhythm_Homo sapiens_hsa04710	0.24272217
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23900529
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23096670
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22922588
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.22465937
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.22304943
97	Axon guidance_Homo sapiens_hsa04360	0.21793671
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.21661098
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.21273254
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.16819145

GNL3LP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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