GNL3LP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.22100222
2positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.88530733
3regulation of cilium movement (GO:0003352)4.67452481
4regulation of nuclear cell cycle DNA replication (GO:0033262)4.48051668
5somite development (GO:0061053)4.36087524
6regulation of mitochondrial translation (GO:0070129)4.21195812
7positive regulation of cell size (GO:0045793)4.01324477
8ribonucleoprotein complex disassembly (GO:0032988)3.84705746
9L-serine metabolic process (GO:0006563)3.54298146
10striatum development (GO:0021756)3.52118856
11replication fork processing (GO:0031297)3.51069369
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.48742673
13cullin deneddylation (GO:0010388)3.46103694
14nonmotile primary cilium assembly (GO:0035058)3.43200658
15DNA strand renaturation (GO:0000733)3.41516045
16negative regulation of execution phase of apoptosis (GO:1900118)3.36108691
17negative regulation of telomere maintenance (GO:0032205)3.29383940
18ribosomal large subunit biogenesis (GO:0042273)3.26791927
19telomere maintenance via telomerase (GO:0007004)3.24078597
20organelle disassembly (GO:1903008)3.19493532
21positive regulation of DNA-dependent DNA replication (GO:2000105)3.14518674
22chromatin remodeling at centromere (GO:0031055)3.12907983
23CENP-A containing nucleosome assembly (GO:0034080)3.12559820
24nuclear pore organization (GO:0006999)3.10949522
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.09332496
26maturation of 5.8S rRNA (GO:0000460)3.02894844
27protein deneddylation (GO:0000338)3.01320380
28mitotic nuclear envelope disassembly (GO:0007077)2.97794604
29DNA replication checkpoint (GO:0000076)2.97063461
30maturation of SSU-rRNA (GO:0030490)2.94483317
31response to pheromone (GO:0019236)2.89449365
32formation of translation preinitiation complex (GO:0001731)2.88268915
33regulation of microtubule-based movement (GO:0060632)2.87922187
34tachykinin receptor signaling pathway (GO:0007217)2.86434783
35olfactory bulb development (GO:0021772)2.84834613
36purine nucleobase biosynthetic process (GO:0009113)2.79221081
37negative regulation of DNA-dependent DNA replication (GO:2000104)2.79100671
38regulation of DNA-dependent DNA replication (GO:0090329)2.77544475
39positive regulation of receptor biosynthetic process (GO:0010870)2.72529963
40DNA replication-dependent nucleosome assembly (GO:0006335)2.72173186
41DNA replication-dependent nucleosome organization (GO:0034723)2.72173186
42resolution of meiotic recombination intermediates (GO:0000712)2.70798719
43DNA replication-independent nucleosome assembly (GO:0006336)2.69049863
44DNA replication-independent nucleosome organization (GO:0034724)2.69049863
45positive regulation of mitochondrial fission (GO:0090141)2.68375231
46DNA ligation (GO:0006266)2.67469101
47nuclear pore complex assembly (GO:0051292)2.66657792
48histone exchange (GO:0043486)2.66184858
49IMP biosynthetic process (GO:0006188)2.64789960
50regulation of DNA endoreduplication (GO:0032875)2.63212859
51branched-chain amino acid catabolic process (GO:0009083)2.58852613
52membrane disassembly (GO:0030397)2.58196520
53nuclear envelope disassembly (GO:0051081)2.58196520
54pyrimidine nucleobase catabolic process (GO:0006208)2.57485964
55regulation of neurotransmitter uptake (GO:0051580)2.56920131
56negative regulation of DNA recombination (GO:0045910)2.55115295
57DNA catabolic process, exonucleolytic (GO:0000738)2.54116701
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54088719
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54000528
60nucleobase biosynthetic process (GO:0046112)2.52999056
61amino acid activation (GO:0043038)2.52798514
62tRNA aminoacylation (GO:0043039)2.52798514
63negative regulation of appetite (GO:0032099)2.51887593
64negative regulation of response to food (GO:0032096)2.51887593
65RNA-dependent DNA replication (GO:0006278)2.51461779
66protein localization to kinetochore (GO:0034501)2.48819968
67heterochromatin organization (GO:0070828)2.48359905
68tRNA aminoacylation for protein translation (GO:0006418)2.47849769
69telomere maintenance via telomere lengthening (GO:0010833)2.47642014
70transcription elongation from RNA polymerase I promoter (GO:0006362)2.46614196
71peptidyl-cysteine modification (GO:0018198)2.45990480
72nucleotide-excision repair, DNA damage removal (GO:0000718)2.45609067
73DNA excision (GO:0044349)2.45609067
74reciprocal DNA recombination (GO:0035825)2.44104008
75reciprocal meiotic recombination (GO:0007131)2.44104008
76negative regulation of vascular permeability (GO:0043116)2.43752590
77regulation of mitotic spindle checkpoint (GO:1903504)2.43725951
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43725951
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42278836
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42278836
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42278836
82folic acid metabolic process (GO:0046655)2.41255434
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40399362
84transcription-coupled nucleotide-excision repair (GO:0006283)2.39736603
85cellular response to leptin stimulus (GO:0044320)2.39583413
86adenine nucleotide transport (GO:0051503)2.39521770
87regulation of appetite (GO:0032098)2.38664261
88termination of RNA polymerase I transcription (GO:0006363)2.38249853
89regulation of stem cell maintenance (GO:2000036)2.37789264
90pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.37711397
91UMP metabolic process (GO:0046049)2.37711397
92pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.37711397
93UMP biosynthetic process (GO:0006222)2.37711397
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.36518754
95fatty acid elongation (GO:0030497)2.36258311
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36140623
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.36140623
98regulation of translation, ncRNA-mediated (GO:0045974)2.36140623
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.35382266
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.35382266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88286907
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.78712538
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.57523010
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56056340
5VDR_22108803_ChIP-Seq_LS180_Human3.45565719
6EZH2_22144423_ChIP-Seq_EOC_Human3.07823001
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.96512272
8ZNF274_21170338_ChIP-Seq_K562_Hela2.94690500
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93285523
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.86669052
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77433015
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77355005
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53210003
14FUS_26573619_Chip-Seq_HEK293_Human2.51535137
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.50757754
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.47304944
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33301754
18ELK1_19687146_ChIP-ChIP_HELA_Human2.25304944
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19034933
20TAF15_26573619_Chip-Seq_HEK293_Human2.17535961
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16862002
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16270207
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.11020427
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97626051
25EWS_26573619_Chip-Seq_HEK293_Human1.95420243
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94590618
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90591631
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88304600
29FOXP3_21729870_ChIP-Seq_TREG_Human1.84519982
30MYC_18940864_ChIP-ChIP_HL60_Human1.72230774
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70226724
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68752564
33XRN2_22483619_ChIP-Seq_HELA_Human1.66432429
34VDR_23849224_ChIP-Seq_CD4+_Human1.59105636
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58241510
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57129570
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53564119
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51405800
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50324943
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48339977
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.47809179
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46136067
43KDM5A_27292631_Chip-Seq_BREAST_Human1.43731178
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41336820
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36927547
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34735021
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.34406884
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34041878
49TTF2_22483619_ChIP-Seq_HELA_Human1.33718019
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32030974
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31833957
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.31050761
53IRF1_19129219_ChIP-ChIP_H3396_Human1.29556213
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29458520
55GABP_19822575_ChIP-Seq_HepG2_Human1.24664228
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21914705
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21166112
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20638024
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19870069
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19514724
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18877625
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17882642
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.13727180
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13351596
65ER_23166858_ChIP-Seq_MCF-7_Human1.09776357
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08490123
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.07127291
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.06107531
69DCP1A_22483619_ChIP-Seq_HELA_Human1.05708091
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03656962
71GBX2_23144817_ChIP-Seq_PC3_Human1.03085411
72P300_19829295_ChIP-Seq_ESCs_Human1.02930516
73IGF1R_20145208_ChIP-Seq_DFB_Human0.96685630
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96291665
75TP53_22573176_ChIP-Seq_HFKS_Human0.94982958
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.93815020
77FLI1_27457419_Chip-Seq_LIVER_Mouse0.93597895
78AR_21909140_ChIP-Seq_LNCAP_Human0.93399952
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93219907
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90969240
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90111313
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88352562
83NANOG_19829295_ChIP-Seq_ESCs_Human0.88160497
84SOX2_19829295_ChIP-Seq_ESCs_Human0.88160497
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88042757
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86977225
87ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86396312
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86218142
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85563941
90GATA1_22025678_ChIP-Seq_K562_Human0.85230999
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84835982
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84609110
93CBP_20019798_ChIP-Seq_JUKART_Human0.81872879
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81872879
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80851797
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78662954
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78489811
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77422108
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.76686593
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75729910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.80849732
2MP0008058_abnormal_DNA_repair4.02862780
3MP0003880_abnormal_central_pattern3.27719203
4MP0002736_abnormal_nociception_after2.89077440
5MP0002938_white_spotting2.77264142
6MP0003136_yellow_coat_color2.42735154
7MP0002234_abnormal_pharynx_morphology2.37330362
8MP0010094_abnormal_chromosome_stability2.34061446
9MP0008789_abnormal_olfactory_epithelium2.20239133
10MP0010030_abnormal_orbit_morphology2.16591877
11MP0000372_irregular_coat_pigmentation2.13253216
12MP0001529_abnormal_vocalization2.11622004
13MP0003693_abnormal_embryo_hatching2.08627932
14MP0008877_abnormal_DNA_methylation2.06050248
15MP0008995_early_reproductive_senescence2.01342638
16MP0005394_taste/olfaction_phenotype1.96218657
17MP0005499_abnormal_olfactory_system1.96218657
18MP0009053_abnormal_anal_canal1.91290478
19MP0002233_abnormal_nose_morphology1.89545580
20MP0006292_abnormal_olfactory_placode1.89458345
21MP0004957_abnormal_blastocyst_morpholog1.78977491
22MP0003646_muscle_fatigue1.78965995
23MP0001984_abnormal_olfaction1.77505562
24MP0005423_abnormal_somatic_nervous1.77374467
25MP0001968_abnormal_touch/_nociception1.70766501
26MP0000537_abnormal_urethra_morphology1.69591536
27MP0003937_abnormal_limbs/digits/tail_de1.66073859
28MP0001293_anophthalmia1.65417657
29MP0003077_abnormal_cell_cycle1.62473349
30MP0000778_abnormal_nervous_system1.57863262
31MP0002277_abnormal_respiratory_mucosa1.52510540
32MP0004233_abnormal_muscle_weight1.51773379
33MP0000516_abnormal_urinary_system1.51467226
34MP0005367_renal/urinary_system_phenotyp1.51467226
35MP0003938_abnormal_ear_development1.48604716
36MP0003718_maternal_effect1.39186461
37MP0003111_abnormal_nucleus_morphology1.33744045
38MP0008932_abnormal_embryonic_tissue1.31236873
39MP0001764_abnormal_homeostasis1.26681147
40MP0008057_abnormal_DNA_replication1.25903303
41MP0002127_abnormal_cardiovascular_syste1.22658530
42MP0006035_abnormal_mitochondrial_morpho1.13197240
43MP0002735_abnormal_chemical_nociception1.13070438
44MP0006072_abnormal_retinal_apoptosis1.12945709
45MP0000631_abnormal_neuroendocrine_gland1.12486629
46MP0000579_abnormal_nail_morphology1.11812360
47MP0008007_abnormal_cellular_replicative1.11202059
48MP0006276_abnormal_autonomic_nervous1.11163784
49MP0008872_abnormal_physiological_respon1.10265254
50MP0002751_abnormal_autonomic_nervous1.10252311
51MP0003890_abnormal_embryonic-extraembry1.08059982
52MP0002184_abnormal_innervation1.07358771
53MP0002084_abnormal_developmental_patter1.05869963
54MP0002111_abnormal_tail_morphology1.05544642
55MP0001697_abnormal_embryo_size1.04851440
56MP0002822_catalepsy1.04830887
57MP0001286_abnormal_eye_development1.04223088
58MP0003755_abnormal_palate_morphology1.03385296
59MP0005645_abnormal_hypothalamus_physiol1.03249799
60MP0003786_premature_aging1.00837398
61MP0003221_abnormal_cardiomyocyte_apopto0.99745851
62MP0003119_abnormal_digestive_system0.99367803
63MP0009379_abnormal_foot_pigmentation0.97015911
64MP0009703_decreased_birth_body0.96690271
65MP0008775_abnormal_heart_ventricle0.95557582
66MP0001672_abnormal_embryogenesis/_devel0.93411533
67MP0005380_embryogenesis_phenotype0.93411533
68MP0003567_abnormal_fetal_cardiomyocyte0.93391954
69MP0004133_heterotaxia0.92638396
70MP0003861_abnormal_nervous_system0.90840213
71MP0000467_abnormal_esophagus_morphology0.90037145
72MP0001929_abnormal_gametogenesis0.89013743
73MP0002734_abnormal_mechanical_nocicepti0.88863808
74MP0002088_abnormal_embryonic_growth/wei0.86466530
75MP0002697_abnormal_eye_size0.85761936
76MP0002210_abnormal_sex_determination0.84725955
77MP0002572_abnormal_emotion/affect_behav0.84285718
78MP0002085_abnormal_embryonic_tissue0.84274646
79MP0003935_abnormal_craniofacial_develop0.84249298
80MP0003984_embryonic_growth_retardation0.84218450
81MP0003315_abnormal_perineum_morphology0.83817251
82MP0005167_abnormal_blood-brain_barrier0.83639285
83MP0010368_abnormal_lymphatic_system0.82761030
84MP0009672_abnormal_birth_weight0.81837981
85MP0000049_abnormal_middle_ear0.81224976
86MP0001485_abnormal_pinna_reflex0.81154144
87MP0000383_abnormal_hair_follicle0.80715849
88MP0004043_abnormal_pH_regulation0.79726850
89MP0001145_abnormal_male_reproductive0.79540587
90MP0002109_abnormal_limb_morphology0.79310093
91MP0009697_abnormal_copulation0.79266319
92MP0002272_abnormal_nervous_system0.79003159
93MP0000647_abnormal_sebaceous_gland0.77611371
94MP0005551_abnormal_eye_electrophysiolog0.73588017
95MP0004811_abnormal_neuron_physiology0.73458158
96MP0000653_abnormal_sex_gland0.73064751
97MP0002282_abnormal_trachea_morphology0.72466664
98MP0000350_abnormal_cell_proliferation0.71318283
99MP0003698_abnormal_male_reproductive0.70775456
100MP0010307_abnormal_tumor_latency0.70196311

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.47446896
2Reticulocytopenia (HP:0001896)3.42179774
3Esophageal atresia (HP:0002032)3.13971464
4Gait imbalance (HP:0002141)3.06040562
5Abnormality of chromosome stability (HP:0003220)3.05792132
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.05396618
7Abnormality of the labia minora (HP:0012880)3.04244709
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98078224
9Meckel diverticulum (HP:0002245)2.97343648
10Congenital primary aphakia (HP:0007707)2.93109828
11Spastic diplegia (HP:0001264)2.88490687
12Absent thumb (HP:0009777)2.86902734
13Anal stenosis (HP:0002025)2.82467858
14Medial flaring of the eyebrow (HP:0010747)2.76616414
15Abnormality of the ileum (HP:0001549)2.75178035
16Stenosis of the external auditory canal (HP:0000402)2.73876545
17Nephrogenic diabetes insipidus (HP:0009806)2.73766392
18Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.63573677
19Vertebral hypoplasia (HP:0008417)2.63573677
20Ectopic kidney (HP:0000086)2.53928040
21Pancreatic cysts (HP:0001737)2.50853941
22Abnormality of the carotid arteries (HP:0005344)2.50222134
23Cortical dysplasia (HP:0002539)2.49264228
24Septo-optic dysplasia (HP:0100842)2.41101544
25Gonadotropin excess (HP:0000837)2.40662193
26Vaginal atresia (HP:0000148)2.39290482
27Preaxial foot polydactyly (HP:0001841)2.39038988
28Hypoplastic pelvis (HP:0008839)2.38128804
29Overriding aorta (HP:0002623)2.35386042
30Triphalangeal thumb (HP:0001199)2.34399752
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34025316
32Trigonocephaly (HP:0000243)2.27823116
33Duplication of thumb phalanx (HP:0009942)2.27165713
34Abnormality of the preputium (HP:0100587)2.26073368
35Microvesicular hepatic steatosis (HP:0001414)2.25804454
36Sparse lateral eyebrow (HP:0005338)2.22041498
37Genital tract atresia (HP:0001827)2.21905623
38Poor coordination (HP:0002370)2.19671229
39Absent radius (HP:0003974)2.19527739
40Aplasia involving forearm bones (HP:0009822)2.17117211
41Absent forearm bone (HP:0003953)2.17117211
42Lower limb hyperreflexia (HP:0002395)2.16660069
43Posterior subcapsular cataract (HP:0007787)2.16365903
44Sensory axonal neuropathy (HP:0003390)2.14372652
45Abnormality of serum amino acid levels (HP:0003112)2.13115337
46Short 5th finger (HP:0009237)2.13115088
47Cerebral hypomyelination (HP:0006808)2.12822438
48Absent septum pellucidum (HP:0001331)2.12099417
49Hyperglycinemia (HP:0002154)2.11845479
50Abnormality of glycolysis (HP:0004366)2.11305127
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10598971
52Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10007157
53Supernumerary spleens (HP:0009799)2.09853642
54Abnormality of the diencephalon (HP:0010662)2.09439189
55Atonic seizures (HP:0010819)2.08840219
56Abnormality of methionine metabolism (HP:0010901)2.07169542
57Hypoplastic labia majora (HP:0000059)2.06441360
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06150453
59Abnormality of alanine metabolism (HP:0010916)2.06150453
60Hyperalaninemia (HP:0003348)2.06150453
61Abnormality of cochlea (HP:0000375)2.03942776
62Pancreatic fibrosis (HP:0100732)2.02032605
63Hemivertebrae (HP:0002937)1.99956084
64Increased nuchal translucency (HP:0010880)1.98961009
65Pheochromocytoma (HP:0002666)1.97160226
66Abnormality of the septum pellucidum (HP:0007375)1.95645780
67Labial hypoplasia (HP:0000066)1.92039455
68Thyroid-stimulating hormone excess (HP:0002925)1.91699837
69Fibular aplasia (HP:0002990)1.91563725
70Broad foot (HP:0001769)1.90342679
71Capillary hemangiomas (HP:0005306)1.89154252
72Sclerocornea (HP:0000647)1.86686086
73Preaxial hand polydactyly (HP:0001177)1.86262048
74Exercise-induced muscle cramps (HP:0003710)1.86035547
75Birth length less than 3rd percentile (HP:0003561)1.85902361
76Small intestinal stenosis (HP:0012848)1.85342919
77Duodenal stenosis (HP:0100867)1.85342919
78Intellectual disability, moderate (HP:0002342)1.83340779
79Facial cleft (HP:0002006)1.83066563
80Hypoplastic female external genitalia (HP:0012815)1.82426633
81Abnormality of the labia majora (HP:0012881)1.81405363
82Astigmatism (HP:0000483)1.81326973
83Concave nail (HP:0001598)1.79442910
84Micropenis (HP:0000054)1.79270007
85Intestinal fistula (HP:0100819)1.79081164
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.77803251
87Increased serum pyruvate (HP:0003542)1.77418117
88Depressed nasal tip (HP:0000437)1.77180399
89Gastrointestinal atresia (HP:0002589)1.76925875
90True hermaphroditism (HP:0010459)1.76538334
91Abolished electroretinogram (ERG) (HP:0000550)1.76428493
92Rib fusion (HP:0000902)1.76323348
93Abnormality of the duodenum (HP:0002246)1.76280599
94Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72832566
95CNS hypomyelination (HP:0003429)1.72747735
96Synostosis involving the elbow (HP:0003938)1.72692444
97Humeroradial synostosis (HP:0003041)1.72692444
98Microglossia (HP:0000171)1.71709359
99Neuroendocrine neoplasm (HP:0100634)1.70830349
100Pendular nystagmus (HP:0012043)1.70261395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.65065558
2SRPK13.59142135
3WNK43.35893951
4STK243.33802324
5ZAK3.31642074
6STK393.15850027
7PDK23.00506025
8PINK12.39974407
9WEE12.33204937
10MAP3K22.25214310
11CCNB12.24417596
12TTK2.23034141
13TSSK62.18986517
14MAP3K122.14083096
15EIF2AK31.98373883
16BUB11.97373243
17CASK1.83630708
18BRSK21.82147107
19BCKDK1.80855875
20CDC71.80807512
21MKNK11.75333384
22NEK11.66982042
23EIF2AK11.64543369
24STK38L1.51375256
25TNIK1.48621554
26PBK1.46718996
27TRIM281.44822212
28CHEK21.39616533
29PLK31.38658684
30MAP3K41.31460454
31MKNK21.30860237
32WNK31.21407606
33PASK1.18586558
34BCR1.18447908
35WNK11.15857019
36EIF2AK21.10971667
37MAPK131.06600236
38MAPKAPK31.03728298
39CSNK1G11.03675759
40CSNK1A1L1.03255748
41CSNK1G31.01325389
42DYRK31.01158167
43PAK31.00921168
44PLK11.00895126
45DYRK20.98483936
46RPS6KA40.98282969
47MINK10.96816485
48CAMK10.94557092
49ATR0.92367804
50CDK80.91629545
51VRK20.84984811
52MAP4K20.81835607
53CSNK1G20.77702318
54MAP3K90.76117920
55FGFR20.75726611
56AURKB0.73797968
57ATM0.70385925
58CLK10.70347654
59CHEK10.68028482
60PNCK0.67826640
61CSNK1E0.61885156
62NEK20.61152308
63BRSK10.60581930
64STK160.59591699
65PLK40.58661275
66BMPR1B0.57637098
67PLK20.55875351
68NEK60.55236317
69MAP2K70.54700980
70FGFR10.54444327
71PRKCE0.53892307
72NTRK20.52863925
73CSNK2A20.51107009
74MAP2K40.50921710
75CSNK2A10.48454086
76ERBB30.48256385
77MARK10.47015050
78MST40.46790439
79KSR10.46659558
80MAP3K30.45997058
81ILK0.43996066
82EEF2K0.42938372
83PRKCG0.39073266
84CDK20.38936638
85FLT30.38109804
86TGFBR10.36674108
87AKT30.35559252
88PAK20.34636881
89EPHA20.33710722
90EGFR0.33537279
91CDK70.32511525
92CDK90.31469975
93FRK0.31351230
94STK30.31250973
95CDK10.30338806
96RPS6KB20.30293541
97TEC0.29296483
98NEK90.29158956
99CAMK40.28557134
100PRKDC0.26798562

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.25874142
2Proteasome_Homo sapiens_hsa030503.11299599
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82767579
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71621296
5Homologous recombination_Homo sapiens_hsa034402.58732269
6RNA transport_Homo sapiens_hsa030132.58586439
7Nucleotide excision repair_Homo sapiens_hsa034202.56654517
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45033952
9Base excision repair_Homo sapiens_hsa034102.40856688
10Basal transcription factors_Homo sapiens_hsa030222.40412408
11DNA replication_Homo sapiens_hsa030302.31846033
12RNA degradation_Homo sapiens_hsa030182.26528563
13One carbon pool by folate_Homo sapiens_hsa006702.14228304
14Selenocompound metabolism_Homo sapiens_hsa004502.08839554
15Propanoate metabolism_Homo sapiens_hsa006402.08262607
16Protein export_Homo sapiens_hsa030602.07460093
17Fanconi anemia pathway_Homo sapiens_hsa034602.05938086
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03981330
19Mismatch repair_Homo sapiens_hsa034301.94834191
20Fatty acid elongation_Homo sapiens_hsa000621.82739155
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75407137
22Spliceosome_Homo sapiens_hsa030401.72120443
23RNA polymerase_Homo sapiens_hsa030201.70068281
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68422214
25Ribosome_Homo sapiens_hsa030101.68147826
26Steroid biosynthesis_Homo sapiens_hsa001001.64830550
27Biosynthesis of amino acids_Homo sapiens_hsa012301.59219079
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58324868
29Phototransduction_Homo sapiens_hsa047441.56815844
30Oxidative phosphorylation_Homo sapiens_hsa001901.42096418
31Parkinsons disease_Homo sapiens_hsa050121.39304635
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.35340422
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34175110
34mRNA surveillance pathway_Homo sapiens_hsa030151.33817224
35Pyruvate metabolism_Homo sapiens_hsa006201.33359254
36Pyrimidine metabolism_Homo sapiens_hsa002401.22384980
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22052458
38Arginine biosynthesis_Homo sapiens_hsa002201.18558245
39Cell cycle_Homo sapiens_hsa041101.16803202
40Carbon metabolism_Homo sapiens_hsa012001.15755756
41Huntingtons disease_Homo sapiens_hsa050161.10637047
42Butanoate metabolism_Homo sapiens_hsa006501.09518499
43N-Glycan biosynthesis_Homo sapiens_hsa005101.09368404
44Lysine degradation_Homo sapiens_hsa003101.05803683
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04500189
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.01069848
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98683827
48Alzheimers disease_Homo sapiens_hsa050100.93865744
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.89991481
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87973848
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86586178
52Purine metabolism_Homo sapiens_hsa002300.78165485
53beta-Alanine metabolism_Homo sapiens_hsa004100.77105945
54Taste transduction_Homo sapiens_hsa047420.76450646
55Oocyte meiosis_Homo sapiens_hsa041140.72641030
56Sulfur relay system_Homo sapiens_hsa041220.70589582
57Hippo signaling pathway_Homo sapiens_hsa043900.70393931
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67117274
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67043610
60Arginine and proline metabolism_Homo sapiens_hsa003300.65366359
61Fatty acid metabolism_Homo sapiens_hsa012120.65239225
62Vitamin B6 metabolism_Homo sapiens_hsa007500.64612428
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61972575
64Metabolic pathways_Homo sapiens_hsa011000.61771491
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59860951
66Nitrogen metabolism_Homo sapiens_hsa009100.58289624
67Hedgehog signaling pathway_Homo sapiens_hsa043400.55350253
68Peroxisome_Homo sapiens_hsa041460.54101632
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53393970
70Vitamin digestion and absorption_Homo sapiens_hsa049770.51880899
71Olfactory transduction_Homo sapiens_hsa047400.51392779
72Sphingolipid metabolism_Homo sapiens_hsa006000.51195889
73Tryptophan metabolism_Homo sapiens_hsa003800.49986865
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49295958
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47220054
76Sulfur metabolism_Homo sapiens_hsa009200.46780394
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46392200
78Glutathione metabolism_Homo sapiens_hsa004800.42506611
79Pentose phosphate pathway_Homo sapiens_hsa000300.41360726
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41279412
81Dopaminergic synapse_Homo sapiens_hsa047280.37927928
82Nicotine addiction_Homo sapiens_hsa050330.37242637
83TGF-beta signaling pathway_Homo sapiens_hsa043500.36576281
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36444981
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33012346
86Ether lipid metabolism_Homo sapiens_hsa005650.28605262
87Cardiac muscle contraction_Homo sapiens_hsa042600.27291060
88Basal cell carcinoma_Homo sapiens_hsa052170.27201529
89Amphetamine addiction_Homo sapiens_hsa050310.26458170
90Galactose metabolism_Homo sapiens_hsa000520.26336371
91Circadian rhythm_Homo sapiens_hsa047100.24272217
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23900529
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.23096670
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22922588
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22465937
96Collecting duct acid secretion_Homo sapiens_hsa049660.22304943
97Axon guidance_Homo sapiens_hsa043600.21793671
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21661098
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21273254
100AMPK signaling pathway_Homo sapiens_hsa041520.16819145

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