GNPAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.63834045
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.48690878
3carnitine shuttle (GO:0006853)5.44544699
4regulation of sequestering of triglyceride (GO:0010889)5.03696127
5fatty acid transmembrane transport (GO:1902001)5.01941430
6regulation of acyl-CoA biosynthetic process (GO:0050812)4.73886832
7carnitine transmembrane transport (GO:1902603)4.67687287
8valine metabolic process (GO:0006573)4.64297982
9regulation of cofactor metabolic process (GO:0051193)4.60840013
10regulation of coenzyme metabolic process (GO:0051196)4.60840013
11sarcomere organization (GO:0045214)4.60196471
12amino-acid betaine transport (GO:0015838)4.42544049
13carnitine transport (GO:0015879)4.42544049
14establishment of integrated proviral latency (GO:0075713)4.40353617
15fatty acid beta-oxidation (GO:0006635)4.31240613
16chromatin remodeling at centromere (GO:0031055)4.29441833
17tricarboxylic acid metabolic process (GO:0072350)4.23464927
18NADH metabolic process (GO:0006734)4.22498287
19actin-myosin filament sliding (GO:0033275)4.21062475
20muscle filament sliding (GO:0030049)4.21062475
21CENP-A containing nucleosome assembly (GO:0034080)4.20194135
22DNA ligation (GO:0006266)4.11681855
23lipid particle organization (GO:0034389)4.05204604
24cardiac myofibril assembly (GO:0055003)4.04145790
25non-recombinational repair (GO:0000726)4.01523492
26double-strand break repair via nonhomologous end joining (GO:0006303)4.01523492
27regulation of fatty acid oxidation (GO:0046320)3.94178645
28negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.93984276
29lysine catabolic process (GO:0006554)3.91639329
30lysine metabolic process (GO:0006553)3.91639329
31biotin metabolic process (GO:0006768)3.81624527
322-oxoglutarate metabolic process (GO:0006103)3.81444514
33DNA damage response, detection of DNA damage (GO:0042769)3.80970397
34oxidative phosphorylation (GO:0006119)3.74336282
35branched-chain amino acid catabolic process (GO:0009083)3.73301414
36regulation of sulfur metabolic process (GO:0042762)3.58100369
37branched-chain amino acid metabolic process (GO:0009081)3.57553491
38myofibril assembly (GO:0030239)3.55896503
39DNA replication-independent nucleosome organization (GO:0034724)3.55443089
40DNA replication-independent nucleosome assembly (GO:0006336)3.55443089
41histone exchange (GO:0043486)3.53340085
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51679507
43negative regulation of potassium ion transmembrane transport (GO:1901380)3.49942300
44oxaloacetate metabolic process (GO:0006107)3.48356140
45pentose-phosphate shunt (GO:0006098)3.46133668
46DNA unwinding involved in DNA replication (GO:0006268)3.45729844
47fatty acid catabolic process (GO:0009062)3.45588478
48succinate metabolic process (GO:0006105)3.42693733
49fatty acid oxidation (GO:0019395)3.41404007
50nuclear pore complex assembly (GO:0051292)3.41071532
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38572441
52cullin deneddylation (GO:0010388)3.38530322
53aspartate family amino acid catabolic process (GO:0009068)3.37479088
54regulation of translational fidelity (GO:0006450)3.34258765
55DNA strand elongation (GO:0022616)3.33302182
56low-density lipoprotein particle clearance (GO:0034383)3.32835227
57lipid oxidation (GO:0034440)3.32483560
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31737045
59quaternary ammonium group transport (GO:0015697)3.28992380
60DNA double-strand break processing (GO:0000729)3.28667155
61cardiac muscle contraction (GO:0060048)3.28485377
62cardiac muscle cell development (GO:0055013)3.25886670
63regulation of skeletal muscle contraction (GO:0014819)3.25560728
64proteasome assembly (GO:0043248)3.23639792
65establishment of viral latency (GO:0019043)3.22741421
66L-serine metabolic process (GO:0006563)3.21921923
67acetyl-CoA metabolic process (GO:0006084)3.21214418
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20870517
69positive regulation of fatty acid oxidation (GO:0046321)3.20644461
70negative regulation of ligase activity (GO:0051352)3.19398228
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19398228
72telomere maintenance via semi-conservative replication (GO:0032201)3.19219882
73actin-mediated cell contraction (GO:0070252)3.18619392
74glycolytic process (GO:0006096)3.18031488
75triglyceride catabolic process (GO:0019433)3.16471461
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.16259503
77IMP metabolic process (GO:0046040)3.15858788
78metaphase plate congression (GO:0051310)3.14162568
79NADPH regeneration (GO:0006740)3.12635747
80negative regulation of DNA recombination (GO:0045910)3.12325407
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11377521
82regulation of mitotic spindle checkpoint (GO:1903504)3.11377521
83negative regulation of cell size (GO:0045792)3.10929080
84mitochondrial fusion (GO:0008053)3.10558202
85IMP biosynthetic process (GO:0006188)3.09196799
86mitotic spindle checkpoint (GO:0071174)3.08628721
87mitotic metaphase plate congression (GO:0007080)3.08397861
88carnitine metabolic process (GO:0009437)3.07531619
89replication fork processing (GO:0031297)3.07189924
90cardiac cell development (GO:0055006)3.06803262
91spindle checkpoint (GO:0031577)3.06385257
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.05545305
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05545305
94pyruvate metabolic process (GO:0006090)3.05345541
95regulation of fatty acid beta-oxidation (GO:0031998)3.04792652
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04407193
97protein localization to kinetochore (GO:0034501)3.04292328
98formation of translation preinitiation complex (GO:0001731)3.02187311
99ribosome assembly (GO:0042255)2.97955534
100DNA strand renaturation (GO:0000733)2.97671274
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97057970
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97057970
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97057970
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.97057970
105negative regulation of sister chromatid segregation (GO:0033046)2.97057970
106purine nucleobase biosynthetic process (GO:0009113)2.94744659
107plasma membrane repair (GO:0001778)2.93923226
108regulation of mitochondrial translation (GO:0070129)2.92290425
109negative regulation of chromosome segregation (GO:0051985)2.91955264
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.91676020
111white fat cell differentiation (GO:0050872)2.90944810
112protein deneddylation (GO:0000338)2.90814480
113mitotic sister chromatid segregation (GO:0000070)2.89327149
114tRNA aminoacylation for protein translation (GO:0006418)2.89218544
115protein neddylation (GO:0045116)2.89049176
116creatine metabolic process (GO:0006600)2.88753610
117fatty acid homeostasis (GO:0055089)2.86652859
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86113934
119peptidyl-lysine dimethylation (GO:0018027)2.85226902
120protein localization to chromosome, centromeric region (GO:0071459)2.85040707
121mitotic spindle assembly checkpoint (GO:0007094)2.83709362
122mitotic recombination (GO:0006312)2.83406649
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82294625
124tRNA aminoacylation (GO:0043039)2.81379210
125amino acid activation (GO:0043038)2.81379210
126telomere maintenance via recombination (GO:0000722)2.80986348
127cardiolipin metabolic process (GO:0032048)2.80254996
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80046558
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80046558
130mitotic sister chromatid cohesion (GO:0007064)2.79462752
131sister chromatid segregation (GO:0000819)2.79159399
132actomyosin structure organization (GO:0031032)2.78831436
133spindle assembly checkpoint (GO:0071173)2.78684093
134brown fat cell differentiation (GO:0050873)2.78643322
135coenzyme A biosynthetic process (GO:0015937)2.78031309
136DNA replication checkpoint (GO:0000076)2.77795456
137acylglycerol catabolic process (GO:0046464)2.77442223
138neutral lipid catabolic process (GO:0046461)2.77442223
139cholesterol biosynthetic process (GO:0006695)2.76683417
140regulation of cellular amino acid metabolic process (GO:0006521)2.76597627
141resolution of meiotic recombination intermediates (GO:0000712)2.76086383
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75995006
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75995006
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75995006
145DNA topological change (GO:0006265)2.75650034
146regulation of DNA endoreduplication (GO:0032875)2.75513992
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74958161
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74958161
149isotype switching (GO:0045190)2.74958161
150ribosomal small subunit assembly (GO:0000028)2.74488465
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.74242061
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73351487
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73351487
154signal transduction involved in cell cycle checkpoint (GO:0072395)2.71755881
155thioester biosynthetic process (GO:0035384)2.71680093
156acyl-CoA biosynthetic process (GO:0071616)2.71680093
157positive regulation of ligase activity (GO:0051351)2.71453409
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71061975
159ATP-dependent chromatin remodeling (GO:0043044)2.70954556
160negative regulation of fatty acid biosynthetic process (GO:0045717)2.69254283
161monocarboxylic acid catabolic process (GO:0072329)2.63815120
162striated muscle contraction (GO:0006941)2.61850412
163binding of sperm to zona pellucida (GO:0007339)2.61842649
164heart trabecula formation (GO:0060347)2.61267503
165nuclear pore organization (GO:0006999)2.59131988
166intracellular lipid transport (GO:0032365)2.58901998
167fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58604598
168gluconeogenesis (GO:0006094)2.57144278
169paraxial mesoderm development (GO:0048339)2.56017134
170cardiac muscle tissue morphogenesis (GO:0055008)2.55642406
171positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55434781
172sperm-egg recognition (GO:0035036)2.55110697
173mitotic nuclear envelope disassembly (GO:0007077)2.53276380
174cellular hyperosmotic response (GO:0071474)2.53091460
175regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.52976293
176DNA strand elongation involved in DNA replication (GO:0006271)2.51773502
177DNA replication-dependent nucleosome assembly (GO:0006335)2.50166858
178DNA replication-dependent nucleosome organization (GO:0034723)2.50166858
179alpha-linolenic acid metabolic process (GO:0036109)2.49054796
180folic acid-containing compound biosynthetic process (GO:0009396)2.48663020
181positive regulation of lipid storage (GO:0010884)2.48139104
182heart process (GO:0003015)2.47853487
183heart contraction (GO:0060047)2.47853487
184regulation of fatty acid metabolic process (GO:0019217)2.47465301
185translesion synthesis (GO:0019985)2.46271028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.12532810
2E2F7_22180533_ChIP-Seq_HELA_Human5.56900264
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64804232
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48219539
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.46359420
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.14981246
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.02000670
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.84290931
9ELK1_19687146_ChIP-ChIP_HELA_Human2.62606902
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52186964
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27877826
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.25720913
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20156364
14ZNF263_19887448_ChIP-Seq_K562_Human2.12541865
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10916590
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10754568
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07803511
18MYC_22102868_ChIP-Seq_BL_Human2.07624751
19* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03779360
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90512017
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90206789
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88086310
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87245014
24* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83790712
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79983915
26CLOCK_20551151_ChIP-Seq_293T_Human1.79510095
27CIITA_25753668_ChIP-Seq_RAJI_Human1.77086718
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75482556
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75391753
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75280420
31AR_21909140_ChIP-Seq_LNCAP_Human1.74767020
32TTF2_22483619_ChIP-Seq_HELA_Human1.70322846
33* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69718634
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68501943
35XRN2_22483619_ChIP-Seq_HELA_Human1.64632577
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64230853
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60759854
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59837836
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.53687798
40VDR_21846776_ChIP-Seq_THP-1_Human1.46752956
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46714037
42* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46042148
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46041743
44NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45944918
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44994737
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.43350223
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.43350223
48MYC_18940864_ChIP-ChIP_HL60_Human1.41499330
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41389561
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39935563
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38898065
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38191646
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37777982
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37451263
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.37225451
56FUS_26573619_Chip-Seq_HEK293_Human1.37059983
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35822660
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33198176
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31641311
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31547832
61IGF1R_20145208_ChIP-Seq_DFB_Human1.30943133
62EWS_26573619_Chip-Seq_HEK293_Human1.30617948
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30604018
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29755203
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29271088
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27380699
67GABP_19822575_ChIP-Seq_HepG2_Human1.27190924
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25347946
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24243428
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24145669
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23432564
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23318615
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.23158547
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.23137413
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20250837
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18984748
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18696463
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.17078492
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16761351
80FOXP3_21729870_ChIP-Seq_TREG_Human1.15460223
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15319547
82DCP1A_22483619_ChIP-Seq_HELA_Human1.15025715
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.13625473
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.13564275
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13328950
86P68_20966046_ChIP-Seq_HELA_Human1.12508057
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.11549806
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10955553
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10817612
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.10338175
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09832092
92* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08045448
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07802242
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07305065
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06909963
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.06548264
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06184935
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.06047858
99* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05351518
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05050119
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04589000
102IRF1_19129219_ChIP-ChIP_H3396_Human1.04433670
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04375459
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04314750
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03878373
106KDM2B_26808549_Chip-Seq_DND41_Human1.02702359
107* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02188260
108KDM5A_27292631_Chip-Seq_BREAST_Human1.02159232
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02019719
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.01851766
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01848419
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.00125156
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97877744
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97828641
115TCF7_22412390_ChIP-Seq_EML_Mouse0.97722312
116ATF3_27146783_Chip-Seq_COLON_Human0.96636361
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96564208
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96453685
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95696228
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95583848
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95448576
122BCL6_27268052_Chip-Seq_Bcells_Human0.94595390
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94513471
124VDR_23849224_ChIP-Seq_CD4+_Human0.94231559
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94053544
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.93216954
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.92506125
128FOXP1_21924763_ChIP-Seq_HESCs_Human0.92347253
129GABP_17652178_ChIP-ChIP_JURKAT_Human0.91795774
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90698269
131BCOR_27268052_Chip-Seq_Bcells_Human0.90513643
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90273386
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90205570
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89683762
135ZNF274_21170338_ChIP-Seq_K562_Hela0.89565429
136SPI1_20517297_ChIP-Seq_HL60_Human0.88929952
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88448354
138PHF8_20622854_ChIP-Seq_HELA_Human0.86491401
139LXR_22292898_ChIP-Seq_THP-1_Human0.86148832
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85976618
141* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85621797
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.82422676
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80419812
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80390647
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.76642781
146* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75469191
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74815526
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.74048810
149TP63_19390658_ChIP-ChIP_HaCaT_Human0.73855686
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72655053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.25899647
2MP0002837_dystrophic_cardiac_calcinosis4.24828252
3MP0005670_abnormal_white_adipose4.00661053
4MP0004084_abnormal_cardiac_muscle3.64507612
5MP0008058_abnormal_DNA_repair3.57739858
6MP0000751_myopathy3.24262384
7MP0004130_abnormal_muscle_cell3.22868131
8MP0005666_abnormal_adipose_tissue3.21717540
9MP0000749_muscle_degeneration2.86407873
10MP0009697_abnormal_copulation2.81543109
11MP0004036_abnormal_muscle_relaxation2.73856667
12MP0008932_abnormal_embryonic_tissue2.73690228
13MP0004215_abnormal_myocardial_fiber2.72798636
14MP0005330_cardiomyopathy2.66257334
15MP0004185_abnormal_adipocyte_glucose2.52108466
16MP0004087_abnormal_muscle_fiber2.47819480
17MP0008789_abnormal_olfactory_epithelium2.46946351
18MP0006292_abnormal_olfactory_placode2.33850639
19MP0002269_muscular_atrophy2.27827771
20MP0006036_abnormal_mitochondrial_physio2.23652679
21MP0004233_abnormal_muscle_weight2.22538629
22MP0000750_abnormal_muscle_regeneration2.21252901
23MP0005375_adipose_tissue_phenotype2.19549597
24MP0010630_abnormal_cardiac_muscle2.09925403
25MP0008775_abnormal_heart_ventricle2.07462410
26MP0003221_abnormal_cardiomyocyte_apopto2.05961236
27MP0003890_abnormal_embryonic-extraembry2.05707668
28MP0001293_anophthalmia2.01893913
29MP0003186_abnormal_redox_activity2.00307855
30MP0003806_abnormal_nucleotide_metabolis1.96207566
31MP0003718_maternal_effect1.93372620
32MP0005394_taste/olfaction_phenotype1.92885018
33MP0005499_abnormal_olfactory_system1.92885018
34MP0002106_abnormal_muscle_physiology1.87102711
35MP0001529_abnormal_vocalization1.85413007
36MP0005385_cardiovascular_system_phenoty1.85317280
37MP0001544_abnormal_cardiovascular_syste1.85317280
38MP0002233_abnormal_nose_morphology1.84374734
39MP0000747_muscle_weakness1.82170842
40MP0003941_abnormal_skin_development1.80499611
41MP0004145_abnormal_muscle_electrophysio1.80212454
42MP0000759_abnormal_skeletal_muscle1.79945033
43MP0005410_abnormal_fertilization1.76274504
44MP0005620_abnormal_muscle_contractility1.76038359
45MP0003122_maternal_imprinting1.72334001
46MP0006138_congestive_heart_failure1.70280591
47MP0002972_abnormal_cardiac_muscle1.70238358
48MP0003137_abnormal_impulse_conducting1.63772120
49MP0003121_genomic_imprinting1.59432984
50MP0002938_white_spotting1.52773469
51MP0003315_abnormal_perineum_morphology1.52633724
52MP0002971_abnormal_brown_adipose1.51335351
53MP0005369_muscle_phenotype1.47259456
54MP0003011_delayed_dark_adaptation1.46508263
55MP0001984_abnormal_olfaction1.42355394
56MP0003786_premature_aging1.41142052
57MP0000003_abnormal_adipose_tissue1.37498079
58MP0003567_abnormal_fetal_cardiomyocyte1.36331638
59MP0003950_abnormal_plasma_membrane1.35215275
60MP0002102_abnormal_ear_morphology1.34639846
61MP0010094_abnormal_chromosome_stability1.31929187
62MP0005187_abnormal_penis_morphology1.30683567
63MP0001730_embryonic_growth_arrest1.30502043
64MP0008877_abnormal_DNA_methylation1.28821688
65MP0006072_abnormal_retinal_apoptosis1.24360735
66MP0008438_abnormal_cutaneous_collagen1.23981787
67MP0003705_abnormal_hypodermis_morpholog1.23496337
68MP0003077_abnormal_cell_cycle1.21904766
69MP0003111_abnormal_nucleus_morphology1.20973737
70MP0003984_embryonic_growth_retardation1.19796782
71MP0004957_abnormal_blastocyst_morpholog1.19004239
72MP0003385_abnormal_body_wall1.18742237
73MP0002088_abnormal_embryonic_growth/wei1.17057675
74MP0003828_pulmonary_edema1.15126759
75MP0002970_abnormal_white_adipose1.14898984
76MP0000647_abnormal_sebaceous_gland1.14300340
77MP0006035_abnormal_mitochondrial_morpho1.12050953
78MP0005266_abnormal_metabolism1.12022002
79MP0000013_abnormal_adipose_tissue1.11234019
80MP0000266_abnormal_heart_morphology1.10943552
81* MP0001286_abnormal_eye_development1.08573923
82MP0004197_abnormal_fetal_growth/weight/1.06226583
83MP0001672_abnormal_embryogenesis/_devel1.05763004
84MP0005380_embryogenesis_phenotype1.05763004
85MP0005084_abnormal_gallbladder_morpholo1.04664255
86MP0008961_abnormal_basal_metabolism1.03006166
87MP0009115_abnormal_fat_cell1.02591016
88MP0003937_abnormal_limbs/digits/tail_de1.01866382
89MP0002332_abnormal_exercise_endurance1.01391680
90MP0001697_abnormal_embryo_size1.00435319
91MP0010352_gastrointestinal_tract_polyps0.98993807
92MP0005408_hypopigmentation0.98919537
93MP0002234_abnormal_pharynx_morphology0.98761730
94MP0003123_paternal_imprinting0.98465475
95MP0003755_abnormal_palate_morphology0.96250925
96MP0005076_abnormal_cell_differentiation0.94807044
97MP0003566_abnormal_cell_adhesion0.94426308
98MP0004484_altered_response_of0.93000108
99MP0000372_irregular_coat_pigmentation0.92017965
100MP0000537_abnormal_urethra_morphology0.91310279
101MP0003787_abnormal_imprinting0.91182749
102MP0000733_abnormal_muscle_development0.91141655
103MP0000049_abnormal_middle_ear0.89888163
104MP0002127_abnormal_cardiovascular_syste0.89718922
105MP0002080_prenatal_lethality0.88628002
106MP0001764_abnormal_homeostasis0.88125847
107MP0003693_abnormal_embryo_hatching0.88100727
108* MP0002697_abnormal_eye_size0.87462632
109MP0009672_abnormal_birth_weight0.87410061
110MP0002084_abnormal_developmental_patter0.86768564
111MP0010030_abnormal_orbit_morphology0.83789534
112MP0000313_abnormal_cell_death0.83672898
113MP0001188_hyperpigmentation0.83600082
114MP0005334_abnormal_fat_pad0.82947311
115MP0010329_abnormal_lipoprotein_level0.82268424
116MP0000343_altered_response_to0.81884329
117MP0008057_abnormal_DNA_replication0.81121806
118MP0005085_abnormal_gallbladder_physiolo0.80746986
119MP0004147_increased_porphyrin_level0.80296578
120MP0001661_extended_life_span0.79209820
121MP0002085_abnormal_embryonic_tissue0.78822975
122MP0000358_abnormal_cell_content/0.77949667
123MP0002396_abnormal_hematopoietic_system0.77788967
124MP0002751_abnormal_autonomic_nervous0.77484312
125MP0005319_abnormal_enzyme/_coenzyme0.77374534
126* MP0001929_abnormal_gametogenesis0.75605356
127MP0002653_abnormal_ependyma_morphology0.75224763
128MP0000350_abnormal_cell_proliferation0.73244947
129MP0010307_abnormal_tumor_latency0.73137737
130MP0004133_heterotaxia0.72475237
131MP0002108_abnormal_muscle_morphology0.72437254
132MP0005253_abnormal_eye_physiology0.72374538
133* MP0002118_abnormal_lipid_homeostasis0.72153734
134* MP0002210_abnormal_sex_determination0.71899877
135MP0004085_abnormal_heartbeat0.71212121
136MP0002086_abnormal_extraembryonic_tissu0.71134409
137MP0003119_abnormal_digestive_system0.68951237
138MP0005332_abnormal_amino_acid0.68604710
139MP0001299_abnormal_eye_distance/0.68349976
140MP0009703_decreased_birth_body0.67882509
141* MP0000653_abnormal_sex_gland0.67842596
142MP0005275_abnormal_skin_tensile0.66571154
143MP0003115_abnormal_respiratory_system0.66284100
144MP0005365_abnormal_bile_salt0.65683188
145MP0002078_abnormal_glucose_homeostasis0.65566413
146MP0000609_abnormal_liver_physiology0.64983983
147MP0003283_abnormal_digestive_organ0.64360419
148MP0008007_abnormal_cellular_replicative0.64194168

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)6.39453056
2Rhabdomyolysis (HP:0003201)5.66504441
3Exercise-induced myalgia (HP:0003738)5.41981204
4Exercise-induced muscle cramps (HP:0003710)5.41432092
5Sudden death (HP:0001699)4.48307858
6Difficulty running (HP:0009046)4.20947580
7Ventricular tachycardia (HP:0004756)4.13143447
8Calf muscle hypertrophy (HP:0008981)3.88863938
9Hyporeflexia of lower limbs (HP:0002600)3.85611495
10Lipoatrophy (HP:0100578)3.77855283
11Muscle fiber splitting (HP:0003555)3.74274852
12Hypoglycemic coma (HP:0001325)3.74086935
13Increased connective tissue (HP:0009025)3.60883766
14Muscle hypertrophy of the lower extremities (HP:0008968)3.58584282
15Colon cancer (HP:0003003)3.52042709
16Abnormality of fatty-acid metabolism (HP:0004359)3.45247516
17Dicarboxylic aciduria (HP:0003215)3.33696564
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.33696564
19Acute necrotizing encephalopathy (HP:0006965)3.32279375
20Hyperglycinuria (HP:0003108)3.23340079
21Atrial fibrillation (HP:0005110)3.18466952
22Dilated cardiomyopathy (HP:0001644)3.18197366
23Ketoacidosis (HP:0001993)3.17853615
24Palpitations (HP:0001962)3.13958123
25Type 1 muscle fiber predominance (HP:0003803)3.09754943
26Abnormality of the left ventricular outflow tract (HP:0011103)3.09293877
27Subaortic stenosis (HP:0001682)3.09293877
28Hepatic necrosis (HP:0002605)3.02976386
29Rimmed vacuoles (HP:0003805)3.02925069
30Muscle fiber inclusion bodies (HP:0100299)3.00408983
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96552926
32Abnormality of the calf musculature (HP:0001430)2.96093529
33Ketosis (HP:0001946)2.94944028
34Increased muscle lipid content (HP:0009058)2.94067792
35Primary atrial arrhythmia (HP:0001692)2.93285739
36Supraventricular tachycardia (HP:0004755)2.92738036
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90632736
38Supraventricular arrhythmia (HP:0005115)2.89751145
39Chromsome breakage (HP:0040012)2.86105360
40Asymmetric septal hypertrophy (HP:0001670)2.85911098
41Muscle stiffness (HP:0003552)2.84641478
42Multiple enchondromatosis (HP:0005701)2.83614012
43Right ventricular cardiomyopathy (HP:0011663)2.79455595
44Reticulocytopenia (HP:0001896)2.78592815
45Abnormality of serine family amino acid metabolism (HP:0010894)2.77798342
46Abnormality of glycine metabolism (HP:0010895)2.77798342
47Hyperglycinemia (HP:0002154)2.77415435
48Ependymoma (HP:0002888)2.72298553
49Hyperammonemia (HP:0001987)2.69764408
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68181206
51Ragged-red muscle fibers (HP:0003200)2.66742571
52Abnormality of the labia minora (HP:0012880)2.62733346
53Increased serum pyruvate (HP:0003542)2.61417367
54Abnormality of glycolysis (HP:0004366)2.61417367
55Progressive macrocephaly (HP:0004481)2.60628699
56EMG: myopathic abnormalities (HP:0003458)2.59426086
57Cortical dysplasia (HP:0002539)2.58094575
58Difficulty climbing stairs (HP:0003551)2.54417963
59Microvesicular hepatic steatosis (HP:0001414)2.50283954
60Bundle branch block (HP:0011710)2.48697365
61Nemaline bodies (HP:0003798)2.48694024
62Generalized aminoaciduria (HP:0002909)2.45844118
63Hyperalaninemia (HP:0003348)2.45783292
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45783292
65Abnormality of alanine metabolism (HP:0010916)2.45783292
66Pancreatic islet-cell hyperplasia (HP:0004510)2.43344678
67Increased CSF lactate (HP:0002490)2.42847159
68Hypobetalipoproteinemia (HP:0003563)2.41980092
69Calcaneovalgus deformity (HP:0001848)2.41967064
70Nausea (HP:0002018)2.41719522
71Long clavicles (HP:0000890)2.41027323
72Meckel diverticulum (HP:0002245)2.40332000
73Mitochondrial inheritance (HP:0001427)2.40021938
74Abnormality of methionine metabolism (HP:0010901)2.37920745
75Abnormality of serum amino acid levels (HP:0003112)2.36798286
76Abnormal lung lobation (HP:0002101)2.35518001
77Reduced antithrombin III activity (HP:0001976)2.35445470
78Medulloblastoma (HP:0002885)2.31979278
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30526472
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30526472
81Abnormality of chromosome stability (HP:0003220)2.26787956
82Atrioventricular block (HP:0001678)2.26756722
83Deformed tarsal bones (HP:0008119)2.25313466
84Increased variability in muscle fiber diameter (HP:0003557)2.24001404
85Ventricular arrhythmia (HP:0004308)2.23824068
86Abnormality of the ileum (HP:0001549)2.23659686
87Myotonia (HP:0002486)2.22980066
88Abnormality of skeletal muscle fiber size (HP:0012084)2.22826253
89Hepatoblastoma (HP:0002884)2.21598187
90Hepatocellular necrosis (HP:0001404)2.21454649
91Adenoma sebaceum (HP:0009720)2.19642626
92Angiofibromas (HP:0010615)2.19642626
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.16060768
94Type 2 muscle fiber atrophy (HP:0003554)2.14149172
95Rhabdomyosarcoma (HP:0002859)2.11082570
96Increased hepatocellular lipid droplets (HP:0006565)2.09868787
97Neck muscle weakness (HP:0000467)2.09682760
98Hypoplastic pelvis (HP:0008839)2.09443032
99Heart block (HP:0012722)2.09267204
100Limb-girdle muscle atrophy (HP:0003797)2.06091069
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06001509
102Proximal tubulopathy (HP:0000114)2.05238396
103Lactic acidosis (HP:0003128)2.03910187
104Hypertriglyceridemia (HP:0002155)2.03853519
105EMG: neuropathic changes (HP:0003445)2.03607477
106Hamartoma of the eye (HP:0010568)2.02684617
107Neoplasm of the adrenal gland (HP:0100631)2.02633087
108Abnormality of the preputium (HP:0100587)2.02333014
109Abnormal mitochondria in muscle tissue (HP:0008316)2.01634685
110Lipid accumulation in hepatocytes (HP:0006561)1.99457451
111Ulnar deviation of the wrist (HP:0003049)1.99416994
112Postnatal microcephaly (HP:0005484)1.98592801
113Distal arthrogryposis (HP:0005684)1.97914652
114Increased serum lactate (HP:0002151)1.97911921
115Cerebral edema (HP:0002181)1.95349433
116Papillary thyroid carcinoma (HP:0002895)1.93844973
117Progressive muscle weakness (HP:0003323)1.93804961
118Large hands (HP:0001176)1.93264463
119Proximal amyotrophy (HP:0007126)1.92932725
120Oligomenorrhea (HP:0000876)1.92716337
121Conjunctival hamartoma (HP:0100780)1.92170969
122Syncope (HP:0001279)1.91186002
123Type I transferrin isoform profile (HP:0003642)1.89532904
124Prenatal maternal abnormality (HP:0002686)1.89027232
125Facial diplegia (HP:0001349)1.88573553
126Generalized muscle weakness (HP:0003324)1.87435559
127Abnormality of the astrocytes (HP:0100707)1.87178562
128Astrocytoma (HP:0009592)1.87178562
129Myopathic facies (HP:0002058)1.87075511
130Toxemia of pregnancy (HP:0100603)1.86311051
131Supernumerary spleens (HP:0009799)1.86218953
132Exercise intolerance (HP:0003546)1.85503640
133Neoplasm of the rectum (HP:0100743)1.85425966
134Shoulder girdle muscle weakness (HP:0003547)1.85290370
135Insulin resistance (HP:0000855)1.85001067
136Abnormality of the hip-girdle musculature (HP:0001445)1.84684519
137Abnormality of the musculature of the pelvis (HP:0001469)1.84684519
138Prolonged QT interval (HP:0001657)1.84263716
139Abnormal atrioventricular conduction (HP:0005150)1.84201007
140Methylmalonic aciduria (HP:0012120)1.83081333
141Neoplasm of head and neck (HP:0012288)1.82930978
142Esophageal neoplasm (HP:0100751)1.82930978
143Acute encephalopathy (HP:0006846)1.82856616
144Acanthosis nigricans (HP:0000956)1.82585399
145Muscle fiber atrophy (HP:0100295)1.81287645
146Progressive external ophthalmoplegia (HP:0000590)1.80177010
147Secondary amenorrhea (HP:0000869)1.79952560
148Amniotic constriction ring (HP:0009775)1.78331753
149Abnormality of placental membranes (HP:0011409)1.78331753
150Nephroblastoma (Wilms tumor) (HP:0002667)1.78153081
151Leukodystrophy (HP:0002415)1.75951392
152Renal cortical cysts (HP:0000803)1.74961393
153Methylmalonic acidemia (HP:0002912)1.74533004
154Lethargy (HP:0001254)1.72704257
155Hyperinsulinemic hypoglycemia (HP:0000825)1.72371536
156Duodenal stenosis (HP:0100867)1.72068599
157Small intestinal stenosis (HP:0012848)1.72068599
158Neoplasm of the colon (HP:0100273)1.71749516
159Acanthocytosis (HP:0001927)1.70725680
160Embryonal renal neoplasm (HP:0011794)1.69929838
161Respiratory failure (HP:0002878)1.68912474
162Malignant hyperthermia (HP:0002047)1.68255140
163Centrally nucleated skeletal muscle fibers (HP:0003687)1.66774202
164Hypolipoproteinemia (HP:0010981)1.66038317
165Myelodysplasia (HP:0002863)1.64329843
166Premature ovarian failure (HP:0008209)1.63043819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.68827043
2PDK34.68827043
3BCKDK4.03308189
4TRIB33.74480731
5TTN3.59096159
6PKN23.38668810
7TRIM282.94894564
8PBK2.84900492
9OBSCN2.80734651
10NEK12.60950348
11BCR2.52281402
12ZAK2.45629860
13PDK22.42805125
14MKNK12.37629348
15EEF2K2.27288057
16MAP3K102.16097591
17EIF2AK32.09708826
18PLK31.97545226
19TESK11.88947163
20ICK1.86465378
21TSSK61.79799528
22PHKG11.79568858
23PHKG21.79568858
24LMTK21.74759139
25PLK41.71872704
26MKNK21.70758303
27NME11.67644028
28MST41.65595668
29TNIK1.64767516
30VRK21.60110316
31SIK11.58890294
32FLT31.55027201
33NEK21.49877595
34CDC71.49479210
35WNK31.45591453
36CAMK1D1.44948989
37STK161.37094664
38VRK11.36603638
39MAP3K41.30224740
40BMPR1B1.28660189
41ERBB31.28375619
42MYLK1.23896567
43PRKD31.22666534
44BUB11.22345916
45WEE11.19554372
46EIF2AK11.18966908
47MAP4K21.18374220
48MAP2K71.16294490
49MAP2K31.15059306
50CSNK1G31.12043212
51CCNB11.11762652
52TTK1.08668720
53CSNK1G11.07356209
54CDK41.06972166
55ERN11.06289873
56PASK1.06173665
57ILK1.04492269
58DMPK1.03569546
59CDK121.01218337
60PAK40.99355185
61LRRK20.96105488
62MTOR0.95161571
63TGFBR10.94681241
64STK240.93919066
65NUAK10.93169934
66MAPKAPK30.93096436
67PINK10.92669933
68TESK20.92051268
69PNCK0.91534072
70CSNK1G20.90997339
71DYRK30.88889021
72CAMK1G0.88398460
73BRAF0.85123616
74FGFR10.84648909
75CHEK20.83971740
76STK100.81786018
77TAF10.81458952
78CSNK1A1L0.80038843
79SCYL20.78918570
80KDR0.77607809
81EIF2AK20.77171381
82STK40.76972894
83MAP3K80.74874012
84PLK20.74737532
85ATR0.71955171
86PDGFRA0.71650055
87MAPK110.69225041
88RIPK10.68308054
89DYRK20.67559767
90TIE10.67099578
91CASK0.67051796
92RPS6KB20.66073482
93BRSK10.65538488
94PRKAA10.65052396
95CDK190.64985082
96STK30.64267613
97PTK60.63191505
98CDK60.62646371
99MAP3K110.62603394
100MAP3K120.61924777
101AKT20.61767187
102MINK10.60813380
103MAP3K70.60489792
104CSNK2A20.60365448
105CDK180.55686674
106WNK40.55064112
107CSNK2A10.54296585
108CDK140.53161974
109AURKB0.53083297
110STK38L0.52954789
111PRKAA20.52941106
112BRD40.51353874
113MAP4K10.51277085
114CSNK1E0.50918678
115ALK0.50716807
116PLK10.50173551
117CDK150.49350936
118MUSK0.49202256
119CDK70.48222703
120CDK11A0.46919058
121EPHB20.46354756
122CHEK10.46074961
123MAP2K40.45965984
124PAK20.45693652
125PIK3CA0.43621395
126LATS10.43483168
127PRKDC0.42507122
128CDK10.40205115
129PRKD10.39258621
130MET0.38031061
131DYRK1B0.36928249
132CDK80.35857807
133PDK10.35516050
134RPS6KA10.34565537
135LIMK10.34317195
136BRSK20.33966714
137NEK90.33837672
138LATS20.33069751
139ACVR1B0.31986523
140MAP2K60.31530620
141INSRR0.30729657
142ARAF0.30617739
143STK380.29974386
144MAP3K50.28981740
145TGFBR20.28171640
146AURKA0.27973606
147SRPK10.27968496
148CDK90.26975020
149ZAP700.26968579
150PTK2B0.26913098
151PIK3CG0.26542400
152ATM0.26130517
153CDK20.25323598
154FGFR40.23852585
155CDC42BPA0.23822892
156RPS6KA40.22895915

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.67478138
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.16140829
3Propanoate metabolism_Homo sapiens_hsa006404.09317854
4Fatty acid degradation_Homo sapiens_hsa000713.16329090
5Carbon metabolism_Homo sapiens_hsa012003.06894375
6Fatty acid metabolism_Homo sapiens_hsa012122.79034579
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76036816
8Pyruvate metabolism_Homo sapiens_hsa006202.62926208
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42098219
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34115500
11Fatty acid biosynthesis_Homo sapiens_hsa000612.29121359
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.16356326
13Biosynthesis of amino acids_Homo sapiens_hsa012302.15871091
14DNA replication_Homo sapiens_hsa030302.14692305
15Protein export_Homo sapiens_hsa030602.11482649
16PPAR signaling pathway_Homo sapiens_hsa033202.05616849
17RNA polymerase_Homo sapiens_hsa030201.90359744
18Steroid biosynthesis_Homo sapiens_hsa001001.75011655
19Mismatch repair_Homo sapiens_hsa034301.61889294
20Cardiac muscle contraction_Homo sapiens_hsa042601.53734937
21Pentose phosphate pathway_Homo sapiens_hsa000301.51319072
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45755509
23Basal transcription factors_Homo sapiens_hsa030221.35455608
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31155959
25AMPK signaling pathway_Homo sapiens_hsa041521.30462534
26Lysine degradation_Homo sapiens_hsa003101.28861363
27Base excision repair_Homo sapiens_hsa034101.23366427
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21659516
29Glucagon signaling pathway_Homo sapiens_hsa049221.21250927
30RNA transport_Homo sapiens_hsa030131.17822080
31Parkinsons disease_Homo sapiens_hsa050121.17409069
32Dilated cardiomyopathy_Homo sapiens_hsa054141.15056916
33Fatty acid elongation_Homo sapiens_hsa000621.14938913
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.08079031
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.06176000
36One carbon pool by folate_Homo sapiens_hsa006701.05104953
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.05027964
38Selenocompound metabolism_Homo sapiens_hsa004501.02843093
39Glycerolipid metabolism_Homo sapiens_hsa005611.01707670
40Fructose and mannose metabolism_Homo sapiens_hsa000510.98998339
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98388753
42beta-Alanine metabolism_Homo sapiens_hsa004100.98263227
43Butanoate metabolism_Homo sapiens_hsa006500.97757159
44Insulin resistance_Homo sapiens_hsa049310.95340049
45Viral myocarditis_Homo sapiens_hsa054160.93991495
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90765685
47Cell cycle_Homo sapiens_hsa041100.89215580
48Spliceosome_Homo sapiens_hsa030400.88952422
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88199136
50Huntingtons disease_Homo sapiens_hsa050160.88031183
51Sulfur relay system_Homo sapiens_hsa041220.87635540
52Insulin signaling pathway_Homo sapiens_hsa049100.87053801
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83175275
54Galactose metabolism_Homo sapiens_hsa000520.81570733
55Tryptophan metabolism_Homo sapiens_hsa003800.79729317
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79406193
57* Peroxisome_Homo sapiens_hsa041460.78966284
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78191171
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76448775
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76247941
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75583899
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72879847
63mRNA surveillance pathway_Homo sapiens_hsa030150.71778116
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.70144168
65Starch and sucrose metabolism_Homo sapiens_hsa005000.70022441
66Nucleotide excision repair_Homo sapiens_hsa034200.69797989
67Sulfur metabolism_Homo sapiens_hsa009200.68572219
68Nitrogen metabolism_Homo sapiens_hsa009100.68444441
69Homologous recombination_Homo sapiens_hsa034400.68129152
70Oxidative phosphorylation_Homo sapiens_hsa001900.67562417
71Fat digestion and absorption_Homo sapiens_hsa049750.66860364
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62650493
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61044164
74Folate biosynthesis_Homo sapiens_hsa007900.60702229
75Alzheimers disease_Homo sapiens_hsa050100.59656440
76Pyrimidine metabolism_Homo sapiens_hsa002400.58161199
77Caffeine metabolism_Homo sapiens_hsa002320.58125687
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57842326
79HIF-1 signaling pathway_Homo sapiens_hsa040660.56828605
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55602533
81RNA degradation_Homo sapiens_hsa030180.54467816
82p53 signaling pathway_Homo sapiens_hsa041150.53804876
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52363423
84N-Glycan biosynthesis_Homo sapiens_hsa005100.51213069
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51144209
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50617319
87Retinol metabolism_Homo sapiens_hsa008300.49962999
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48489590
89Vitamin digestion and absorption_Homo sapiens_hsa049770.48222830
90mTOR signaling pathway_Homo sapiens_hsa041500.48196984
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47879147
92Glutathione metabolism_Homo sapiens_hsa004800.47271390
93Ribosome_Homo sapiens_hsa030100.46409208
94Arginine and proline metabolism_Homo sapiens_hsa003300.45461492
95Basal cell carcinoma_Homo sapiens_hsa052170.44188979
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43840192
97Oocyte meiosis_Homo sapiens_hsa041140.42165920
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41826261
99Arginine biosynthesis_Homo sapiens_hsa002200.41558838
100Purine metabolism_Homo sapiens_hsa002300.41518960
101Chemical carcinogenesis_Homo sapiens_hsa052040.41172656
102Metabolic pathways_Homo sapiens_hsa011000.39818073
103Fanconi anemia pathway_Homo sapiens_hsa034600.37871696
104Thyroid cancer_Homo sapiens_hsa052160.36858595
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36477288
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35876629
107Vitamin B6 metabolism_Homo sapiens_hsa007500.34984311
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32991397
109Phenylalanine metabolism_Homo sapiens_hsa003600.32576085
110Notch signaling pathway_Homo sapiens_hsa043300.32022300
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30108080
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27964897
113Small cell lung cancer_Homo sapiens_hsa052220.27396617
114Tyrosine metabolism_Homo sapiens_hsa003500.26643215
115HTLV-I infection_Homo sapiens_hsa051660.25942418
116Viral carcinogenesis_Homo sapiens_hsa052030.25635843
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25492470
118Focal adhesion_Homo sapiens_hsa045100.24303458
119Adherens junction_Homo sapiens_hsa045200.24198775
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.23627147
121Non-homologous end-joining_Homo sapiens_hsa034500.23403846
122Proteasome_Homo sapiens_hsa030500.23365742
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23259242
124Tight junction_Homo sapiens_hsa045300.17121204
125Hedgehog signaling pathway_Homo sapiens_hsa043400.14718921
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.13465031
127Alcoholism_Homo sapiens_hsa050340.11542204
128Systemic lupus erythematosus_Homo sapiens_hsa053220.11432604

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