GNPDA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.18206400
2L-serine metabolic process (GO:0006563)4.61424383
3purine nucleobase biosynthetic process (GO:0009113)4.27269178
4folic acid-containing compound biosynthetic process (GO:0009396)4.24708607
5nucleobase biosynthetic process (GO:0046112)4.21423381
6establishment of viral latency (GO:0019043)4.15551398
7formation of translation preinitiation complex (GO:0001731)3.98141297
8IMP biosynthetic process (GO:0006188)3.91036725
9proteasome assembly (GO:0043248)3.87180657
10DNA replication checkpoint (GO:0000076)3.79991322
11protein maturation by protein folding (GO:0022417)3.75992376
12DNA strand elongation involved in DNA replication (GO:0006271)3.74784285
13mitotic nuclear envelope disassembly (GO:0007077)3.68252752
14DNA replication initiation (GO:0006270)3.65926227
15negative regulation of ligase activity (GO:0051352)3.60766565
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60766565
17DNA strand elongation (GO:0022616)3.53885805
18folic acid metabolic process (GO:0046655)3.43195323
19regulation of mitochondrial translation (GO:0070129)3.40720520
20protein localization to kinetochore (GO:0034501)3.40028796
21IMP metabolic process (GO:0046040)3.39545432
22protein complex localization (GO:0031503)3.37664985
23cullin deneddylation (GO:0010388)3.36923971
24telomere maintenance via semi-conservative replication (GO:0032201)3.36617356
25nuclear envelope disassembly (GO:0051081)3.35414722
26membrane disassembly (GO:0030397)3.35414722
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31389042
28mitotic metaphase plate congression (GO:0007080)3.28087534
29regulation of gene silencing by RNA (GO:0060966)3.27708658
30regulation of posttranscriptional gene silencing (GO:0060147)3.27708658
31regulation of gene silencing by miRNA (GO:0060964)3.27708658
32cellular protein complex localization (GO:0034629)3.26230069
33nuclear pore organization (GO:0006999)3.22671075
34COPI coating of Golgi vesicle (GO:0048205)3.17321690
35Golgi transport vesicle coating (GO:0048200)3.17321690
36DNA unwinding involved in DNA replication (GO:0006268)3.14793810
37non-recombinational repair (GO:0000726)3.13816385
38double-strand break repair via nonhomologous end joining (GO:0006303)3.13816385
39DNA replication-dependent nucleosome assembly (GO:0006335)3.09643988
40DNA replication-dependent nucleosome organization (GO:0034723)3.09643988
41amino acid activation (GO:0043038)3.08030569
42tRNA aminoacylation (GO:0043039)3.08030569
43regulation of cellular amino acid metabolic process (GO:0006521)3.06618051
44telomere maintenance via recombination (GO:0000722)3.06373033
45NADPH regeneration (GO:0006740)3.05958113
46protein deneddylation (GO:0000338)3.05694918
47mitotic chromosome condensation (GO:0007076)3.04171528
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.03336547
49B cell mediated immunity (GO:0019724)3.02533716
50nucleobase-containing small molecule interconversion (GO:0015949)3.00098753
51protein K6-linked ubiquitination (GO:0085020)2.98991971
52regulation of ubiquitin-protein transferase activity (GO:0051438)2.98892059
53CENP-A containing nucleosome assembly (GO:0034080)2.98604479
54chromatin remodeling at centromere (GO:0031055)2.97385486
55immunoglobulin mediated immune response (GO:0016064)2.95752437
56ribosome biogenesis (GO:0042254)2.95691753
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95449102
58tetrahydrofolate metabolic process (GO:0046653)2.93529492
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90023505
60glycine metabolic process (GO:0006544)2.89327901
61regulation of ligase activity (GO:0051340)2.88907001
62lactate metabolic process (GO:0006089)2.88730373
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.85444696
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85444696
65nuclear pore complex assembly (GO:0051292)2.84025534
66positive regulation of ligase activity (GO:0051351)2.83897602
67positive regulation of interferon-beta production (GO:0032728)2.77394762
68mitotic recombination (GO:0006312)2.76878068
69heterochromatin organization (GO:0070828)2.76062754
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74680733
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74680733
72folic acid-containing compound metabolic process (GO:0006760)2.74609663
73regulation of translation in response to stress (GO:0043555)2.74447135
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73981356
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73981356
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73981356
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73945817
78DNA ligation (GO:0006266)2.73319721
79spindle checkpoint (GO:0031577)2.73083693
80protein localization to chromosome, centromeric region (GO:0071459)2.72838320
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.71761068
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71761068
83maturation of SSU-rRNA (GO:0030490)2.70861347
84chaperone-mediated protein transport (GO:0072321)2.70530767
85ribosome assembly (GO:0042255)2.70114547
86mitotic spindle checkpoint (GO:0071174)2.69098810
87regulation of spindle organization (GO:0090224)2.68595322
88metaphase plate congression (GO:0051310)2.67707146
89determination of adult lifespan (GO:0008340)2.67646031
90regulation of interferon-beta biosynthetic process (GO:0045357)2.67568422
91positive regulation of chromosome segregation (GO:0051984)2.67232639
92signal transduction involved in cell cycle checkpoint (GO:0072395)2.66840246
93DNA geometric change (GO:0032392)2.66581142
94DNA duplex unwinding (GO:0032508)2.65642319
95negative regulation of chromosome segregation (GO:0051985)2.65453150
96folic acid transport (GO:0015884)2.64024686
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63792567
98spliceosomal snRNP assembly (GO:0000387)2.63167146
99tricarboxylic acid cycle (GO:0006099)2.62731154
100peptidyl-histidine modification (GO:0018202)2.62705794
101pentose metabolic process (GO:0019321)2.62171398
102establishment of chromosome localization (GO:0051303)2.60670703
103glycosphingolipid catabolic process (GO:0046479)2.60462830
104regulation of chromosome segregation (GO:0051983)2.60241557
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58950190
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.58950190
107negative regulation of sister chromatid segregation (GO:0033046)2.58950190
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58950190
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58950190
110pore complex assembly (GO:0046931)2.58942516
111negative regulation of gene silencing (GO:0060969)2.58778687
112paraxial mesoderm development (GO:0048339)2.58468019
113protein targeting to mitochondrion (GO:0006626)2.58148621
114mitotic sister chromatid segregation (GO:0000070)2.57031754
115pteridine-containing compound biosynthetic process (GO:0042559)2.57028558
116positive regulation by symbiont of host defense response (GO:0052509)2.56481231
117modulation by symbiont of host defense response (GO:0052031)2.56481231
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56481231
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56481231
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.56481231
121modulation by symbiont of host immune response (GO:0052553)2.56481231
122telomere maintenance via telomere lengthening (GO:0010833)2.56108227
123negative regulation of protein ubiquitination (GO:0031397)2.55828752
124sister chromatid segregation (GO:0000819)2.55036440
125positive regulation of interferon-alpha production (GO:0032727)2.55034058
126nuclear envelope organization (GO:0006998)2.54000248
127pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.53396056
128L-alpha-amino acid transmembrane transport (GO:1902475)2.52452585
129pentose-phosphate shunt (GO:0006098)2.52249473
130histone arginine methylation (GO:0034969)2.51287916
131neutrophil activation involved in immune response (GO:0002283)2.50823639
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.49039851
133DNA deamination (GO:0045006)2.42995638
134attachment of spindle microtubules to kinetochore (GO:0008608)2.42776622
135regulation of telomere maintenance via telomerase (GO:0032210)2.42212419
136antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40969010
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.40688900
138regulation of interferon-alpha production (GO:0032647)2.40617636
139pinocytosis (GO:0006907)2.39523211
140regulation of mitotic spindle organization (GO:0060236)2.38700402
141serine family amino acid biosynthetic process (GO:0009070)2.37411621
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.37281017
143termination of RNA polymerase III transcription (GO:0006386)2.37281017
144mRNA cleavage (GO:0006379)2.36917355
145regulation of translational fidelity (GO:0006450)2.36735353
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.36544161
147regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36101743
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.35331854
149aspartate family amino acid biosynthetic process (GO:0009067)2.35044290
150regulation of helicase activity (GO:0051095)2.34835553
151transcription-coupled nucleotide-excision repair (GO:0006283)2.34493939
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.34186720
153G1/S transition of mitotic cell cycle (GO:0000082)2.33523117
154cell cycle G1/S phase transition (GO:0044843)2.33523117
155telomere maintenance (GO:0000723)2.33160347
156telomere organization (GO:0032200)2.32842630
157positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.31557038
158sulfur amino acid biosynthetic process (GO:0000097)2.31256305
159pteridine-containing compound metabolic process (GO:0042558)2.30808230
160serine family amino acid metabolic process (GO:0009069)2.30622787
161positive regulation of protein import into nucleus, translocation (GO:0033160)2.30182856
162ribonucleoprotein complex biogenesis (GO:0022613)2.28609587
163tRNA aminoacylation for protein translation (GO:0006418)2.28310077
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27991204
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26744085
166regulation of interferon-beta production (GO:0032648)2.26340383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.12766390
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32009988
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.17768021
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.80410648
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55125337
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54879704
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.35097093
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33001262
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28735048
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28660252
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.28299377
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26609451
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.25981089
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25699786
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.07636234
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07587279
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04871529
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.01990541
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01305996
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99115892
21NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91302373
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88093982
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82663877
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81984929
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81833985
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80132141
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78391211
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72689517
29VDR_23849224_ChIP-Seq_CD4+_Human1.72501212
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70982870
31* TFEB_21752829_ChIP-Seq_HELA_Human1.68908964
32XRN2_22483619_ChIP-Seq_HELA_Human1.68803930
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61130553
34AR_21909140_ChIP-Seq_LNCAP_Human1.60701183
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59825074
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.57830869
37DCP1A_22483619_ChIP-Seq_HELA_Human1.55980994
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54980303
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54507710
40MYC_22102868_ChIP-Seq_BL_Human1.52232577
41FOXP3_21729870_ChIP-Seq_TREG_Human1.51465701
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50071812
43GABP_19822575_ChIP-Seq_HepG2_Human1.48486199
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48476063
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.47484336
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44466845
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42640808
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42240182
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40770290
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38703594
51SOX17_20123909_ChIP-Seq_XEN_Mouse1.38685603
52SPI1_23547873_ChIP-Seq_NB4_Human1.37717600
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.37631069
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37541284
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36955313
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36291015
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36181415
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34963671
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34947250
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33277490
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33175262
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32967698
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.32561865
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31706002
65KDM5A_27292631_Chip-Seq_BREAST_Human1.29293828
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.28943955
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28901757
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27785893
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27532763
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24961896
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24961896
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24961896
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24447747
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23919328
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23059544
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23028241
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21731634
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21689643
79CIITA_25753668_ChIP-Seq_RAJI_Human1.21639143
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21330918
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21310407
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21226306
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19172337
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19104887
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18901926
86* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18552084
87ELK1_19687146_ChIP-ChIP_HELA_Human1.16378269
88ZNF263_19887448_ChIP-Seq_K562_Human1.14088130
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13863112
90TTF2_22483619_ChIP-Seq_HELA_Human1.12596640
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11654587
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.11045522
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10903290
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10055677
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10017216
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09665049
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08874981
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08527637
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08226654
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08122264
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06247543
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.05884884
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05192780
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03887572
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03600432
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.01913280
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01717107
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01630561
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01455413
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00699049
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00578126
112VDR_21846776_ChIP-Seq_THP-1_Human1.00414089
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99906711
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99826309
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.98153736
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98030138
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97957232
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97566538
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97506423
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97161908
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97089802
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96937193
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96570252
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96361301
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96279443
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95300765
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95104894
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94791342
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.94594485
130CLOCK_20551151_ChIP-Seq_293T_Human0.93938349
131MYC_18940864_ChIP-ChIP_HL60_Human0.92337291
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91696071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.49850561
2MP0003111_abnormal_nucleus_morphology3.23387373
3MP0005058_abnormal_lysosome_morphology3.17569263
4MP0003806_abnormal_nucleotide_metabolis3.06010469
5MP0009840_abnormal_foam_cell3.01611199
6MP0008057_abnormal_DNA_replication2.97570819
7MP0004957_abnormal_blastocyst_morpholog2.92783294
8MP0002254_reproductive_system_inflammat2.92294584
9MP0010094_abnormal_chromosome_stability2.86826568
10MP0010030_abnormal_orbit_morphology2.54474675
11MP0003077_abnormal_cell_cycle2.52188114
12MP0003172_abnormal_lysosome_physiology2.40615418
13MP0003941_abnormal_skin_development2.36513150
14MP0001835_abnormal_antigen_presentation2.36191042
15MP0010307_abnormal_tumor_latency2.32807292
16MP0002090_abnormal_vision2.12589647
17MP0008058_abnormal_DNA_repair2.10713521
18MP0005408_hypopigmentation2.06353853
19MP0003136_yellow_coat_color2.01446931
20MP0003186_abnormal_redox_activity2.00104386
21MP0002396_abnormal_hematopoietic_system1.96384348
22MP0010352_gastrointestinal_tract_polyps1.85938773
23MP0005257_abnormal_intraocular_pressure1.84456901
24MP0008007_abnormal_cellular_replicative1.84108733
25MP0003436_decreased_susceptibility_to1.81201658
26MP0006082_CNS_inflammation1.78677550
27MP0002938_white_spotting1.70626772
28MP0005360_urolithiasis1.63880303
29MP0009333_abnormal_splenocyte_physiolog1.62756333
30MP0009697_abnormal_copulation1.62178447
31MP0005671_abnormal_response_to1.61604584
32MP0005248_abnormal_Harderian_gland1.58739068
33MP0009672_abnormal_birth_weight1.58507211
34MP0000689_abnormal_spleen_morphology1.57141073
35MP0002419_abnormal_innate_immunity1.55502808
36MP0006035_abnormal_mitochondrial_morpho1.55254188
37MP0005171_absent_coat_pigmentation1.53569402
38MP0001730_embryonic_growth_arrest1.53143065
39MP0002697_abnormal_eye_size1.50893367
40MP0003566_abnormal_cell_adhesion1.49969371
41MP0002877_abnormal_melanocyte_morpholog1.48044937
42MP0000490_abnormal_crypts_of1.46093317
43MP0002722_abnormal_immune_system1.44254439
44MP0000350_abnormal_cell_proliferation1.44011669
45MP0008260_abnormal_autophagy1.43756222
46MP0002452_abnormal_antigen_presenting1.42151388
47MP0005397_hematopoietic_system_phenotyp1.42100314
48MP0001545_abnormal_hematopoietic_system1.42100314
49MP0010234_abnormal_vibrissa_follicle1.40234575
50MP0002398_abnormal_bone_marrow1.39207910
51MP0002148_abnormal_hypersensitivity_rea1.38545877
52MP0000858_altered_metastatic_potential1.38386753
53MP0005025_abnormal_response_to1.37936119
54MP0001293_anophthalmia1.37060619
55MP0002138_abnormal_hepatobiliary_system1.36575077
56MP0000537_abnormal_urethra_morphology1.36547336
57MP0001800_abnormal_humoral_immune1.36483455
58MP0005000_abnormal_immune_tolerance1.35984897
59MP0002084_abnormal_developmental_patter1.35347977
60MP0000647_abnormal_sebaceous_gland1.34976070
61MP0001849_ear_inflammation1.33846142
62MP0009785_altered_susceptibility_to1.31755017
63MP0001661_extended_life_span1.31627307
64MP0003191_abnormal_cellular_cholesterol1.30761944
65MP0006292_abnormal_olfactory_placode1.30749580
66MP0002085_abnormal_embryonic_tissue1.30167685
67MP0000685_abnormal_immune_system1.30062806
68MP0002019_abnormal_tumor_incidence1.28668481
69MP0002723_abnormal_immune_serum1.27213751
70MP0004264_abnormal_extraembryonic_tissu1.27075600
71MP0004133_heterotaxia1.26887427
72MP0004019_abnormal_vitamin_homeostasis1.26807092
73MP0000428_abnormal_craniofacial_morphol1.26281628
74MP0001819_abnormal_immune_cell1.25380521
75MP0002420_abnormal_adaptive_immunity1.25253730
76MP0008932_abnormal_embryonic_tissue1.24571166
77MP0002429_abnormal_blood_cell1.21984791
78MP0002163_abnormal_gland_morphology1.21808155
79MP0000313_abnormal_cell_death1.21242489
80MP0002405_respiratory_system_inflammati1.20797349
81MP0003448_altered_tumor_morphology1.20639173
82MP0005332_abnormal_amino_acid1.20180004
83MP0000716_abnormal_immune_system1.19756431
84MP0000371_diluted_coat_color1.19029700
85MP0006054_spinal_hemorrhage1.18752867
86MP0003567_abnormal_fetal_cardiomyocyte1.17955570
87MP0005379_endocrine/exocrine_gland_phen1.16676042
88MP0001915_intracranial_hemorrhage1.16558476
89MP0009643_abnormal_urine_homeostasis1.16010584
90MP0002233_abnormal_nose_morphology1.15225703
91MP0005464_abnormal_platelet_physiology1.15166734
92MP0005451_abnormal_body_composition1.15158182
93MP0005387_immune_system_phenotype1.14839011
94MP0001790_abnormal_immune_system1.14839011
95MP0001853_heart_inflammation1.14773387
96MP0004233_abnormal_muscle_weight1.12347919
97MP0005197_abnormal_uvea_morphology1.10437869
98MP0002092_abnormal_eye_morphology1.10305246
99MP0000358_abnormal_cell_content/1.10198415
100MP0004272_abnormal_basement_membrane1.09637930
101MP0001324_abnormal_eye_pigmentation1.08829995
102MP0002111_abnormal_tail_morphology1.08220064
103MP0003221_abnormal_cardiomyocyte_apopto1.07788118
104MP0002086_abnormal_extraembryonic_tissu1.07496557
105MP0008789_abnormal_olfactory_epithelium1.07183630
106MP0001845_abnormal_inflammatory_respons1.06815578
107MP0001984_abnormal_olfaction1.06610578
108MP0003937_abnormal_limbs/digits/tail_de1.06518768
109MP0002080_prenatal_lethality1.05929961
110MP0008469_abnormal_protein_level1.05757453
111MP0003890_abnormal_embryonic-extraembry1.05595198
112MP0001299_abnormal_eye_distance/1.05093055
113MP0001672_abnormal_embryogenesis/_devel1.04862983
114MP0005380_embryogenesis_phenotype1.04862983
115MP0001697_abnormal_embryo_size1.04625338
116MP0000598_abnormal_liver_morphology1.03915908
117MP0003786_premature_aging1.03737132
118MP0006072_abnormal_retinal_apoptosis1.03404573
119MP0000372_irregular_coat_pigmentation1.01249527
120MP0005076_abnormal_cell_differentiation1.00716730
121MP0009053_abnormal_anal_canal1.00708660
122MP0003984_embryonic_growth_retardation1.00543191
123MP0004808_abnormal_hematopoietic_stem0.99639687
124MP0000609_abnormal_liver_physiology0.99162163
125MP0008877_abnormal_DNA_methylation0.98411184
126MP0002638_abnormal_pupillary_reflex0.98108682
127MP0005319_abnormal_enzyme/_coenzyme0.97895558
128MP0002088_abnormal_embryonic_growth/wei0.97881941
129MP0003656_abnormal_erythrocyte_physiolo0.97506464
130MP0003718_maternal_effect0.97281494
131MP0001727_abnormal_embryo_implantation0.95572752
132MP0000343_altered_response_to0.94751038
133MP0000703_abnormal_thymus_morphology0.94267873
134MP0002139_abnormal_hepatobiliary_system0.92886654
135MP0001764_abnormal_homeostasis0.92641076
136MP0003315_abnormal_perineum_morphology0.92470663
137MP0006036_abnormal_mitochondrial_physio0.92427807
138MP0002136_abnormal_kidney_physiology0.90895124
139MP0005310_abnormal_salivary_gland0.85483656
140MP0005193_abnormal_anterior_eye0.84578135
141MP0005391_vision/eye_phenotype0.84077549
142MP0005394_taste/olfaction_phenotype0.84076395
143MP0005499_abnormal_olfactory_system0.84076395
144MP0010155_abnormal_intestine_physiology0.82918657
145MP0003303_peritoneal_inflammation0.82825739
146MP0004197_abnormal_fetal_growth/weight/0.82084710
147MP0003763_abnormal_thymus_physiology0.81817397
148MP0003123_paternal_imprinting0.81809256
149MP0002132_abnormal_respiratory_system0.81756003
150MP0005384_cellular_phenotype0.81652938
151MP0005621_abnormal_cell_physiology0.81554354
152MP0000566_synostosis0.81093387
153MP0003755_abnormal_palate_morphology0.80984345
154MP0009703_decreased_birth_body0.80648947
155MP0005023_abnormal_wound_healing0.79737981
156MP0003634_abnormal_glial_cell0.78765142
157MP0005365_abnormal_bile_salt0.77438436
158MP0005377_hearing/vestibular/ear_phenot0.77429300
159MP0001186_pigmentation_phenotype0.75238987
160MP0003011_delayed_dark_adaptation0.74654187
161MP0000579_abnormal_nail_morphology0.73228483
162MP0002210_abnormal_sex_determination0.71709494
163MP0003453_abnormal_keratinocyte_physiol0.71495342
164MP0005501_abnormal_skin_physiology0.71408364

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)4.83686120
2Vacuolated lymphocytes (HP:0001922)4.31811832
3Birth length less than 3rd percentile (HP:0003561)3.43719696
4Increased cerebral lipofuscin (HP:0011813)3.31806052
5Abnormality of glycolysis (HP:0004366)3.28847872
6Abnormality of macrophages (HP:0004311)3.24547471
7Recurrent abscess formation (HP:0002722)3.23685394
8Hypokinesia (HP:0002375)3.16753839
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.12317404
10Abnormality of the anterior horn cell (HP:0006802)3.11963506
11Degeneration of anterior horn cells (HP:0002398)3.11963506
12Nuclear cataract (HP:0100018)3.11949835
13Increased serum pyruvate (HP:0003542)3.00995862
14Spinal muscular atrophy (HP:0007269)2.85646590
15Abnormality of pyrimidine metabolism (HP:0004353)2.85492149
16Spastic diplegia (HP:0001264)2.83398900
17Personality changes (HP:0000751)2.82071740
18Dysostosis multiplex (HP:0000943)2.80269006
19Systemic lupus erythematosus (HP:0002725)2.79407250
20Cerebral hypomyelination (HP:0006808)2.78015818
21IgM deficiency (HP:0002850)2.77446301
22Multiple enchondromatosis (HP:0005701)2.72534879
23Tongue fasciculations (HP:0001308)2.71075376
24Vertebral compression fractures (HP:0002953)2.69406141
25Breast hypoplasia (HP:0003187)2.68194690
26Microvesicular hepatic steatosis (HP:0001414)2.67483826
27Acute encephalopathy (HP:0006846)2.67333726
28Acute necrotizing encephalopathy (HP:0006965)2.66350823
29Carpal bone hypoplasia (HP:0001498)2.62975735
30Increased hepatocellular lipid droplets (HP:0006565)2.60213220
31Ependymoma (HP:0002888)2.60054804
32Upper motor neuron abnormality (HP:0002127)2.59849215
33Hyperinsulinemic hypoglycemia (HP:0000825)2.54335178
34Chromsome breakage (HP:0040012)2.53569199
35Recurrent bacterial skin infections (HP:0005406)2.50966867
36Medulloblastoma (HP:0002885)2.50214212
37Aplastic anemia (HP:0001915)2.48516886
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.48238574
39Abnormality of glycolipid metabolism (HP:0010969)2.48238574
40Abnormality of liposaccharide metabolism (HP:0010968)2.48238574
41Lipid accumulation in hepatocytes (HP:0006561)2.48001871
42Patchy hypopigmentation of hair (HP:0011365)2.46866757
43Nausea (HP:0002018)2.45598873
44Esophageal neoplasm (HP:0100751)2.44083808
45Neoplasm of head and neck (HP:0012288)2.44083808
46Hypoglycemic coma (HP:0001325)2.43821513
47Autoimmune thrombocytopenia (HP:0001973)2.43624869
48Abnormal mitochondria in muscle tissue (HP:0008316)2.43509083
49Hyperglycinuria (HP:0003108)2.42005588
50Abnormality of the vasculature of the conjunctiva (HP:0008054)2.40059201
51Abnormality of methionine metabolism (HP:0010901)2.36538035
52Hypoglycemic seizures (HP:0002173)2.36531676
53Mucopolysacchariduria (HP:0008155)2.35695784
54Urinary glycosaminoglycan excretion (HP:0003541)2.35695784
55Loss of speech (HP:0002371)2.34064142
56Secondary amenorrhea (HP:0000869)2.33679002
57Abnormality of chromosome stability (HP:0003220)2.33166237
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32375336
59Abnormal gallbladder physiology (HP:0012438)2.32191190
60Cholecystitis (HP:0001082)2.32191190
61Muscle fibrillation (HP:0010546)2.31949477
62Poor head control (HP:0002421)2.31680334
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31646726
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31646726
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31386088
66Colon cancer (HP:0003003)2.29611748
67Rough bone trabeculation (HP:0100670)2.28728908
68Impulsivity (HP:0100710)2.27623821
69Recurrent gram-negative bacterial infections (HP:0005420)2.27242037
70Symptomatic seizures (HP:0011145)2.25773560
71Eczematoid dermatitis (HP:0000976)2.25552660
72Rhabdomyosarcoma (HP:0002859)2.19356027
73White forelock (HP:0002211)2.19341490
74Postnatal microcephaly (HP:0005484)2.18538138
75Increased CSF lactate (HP:0002490)2.14934931
76Metaphyseal cupping (HP:0003021)2.13802350
77Myelodysplasia (HP:0002863)2.11797320
78Amaurosis fugax (HP:0100576)2.10673964
79Abnormal neuron morphology (HP:0012757)2.10594914
80Abnormality of the motor neurons (HP:0002450)2.10594914
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10166898
82Abnormality of polysaccharide metabolism (HP:0011012)2.10166898
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10166898
84Hand muscle atrophy (HP:0009130)2.07283979
85Renal Fanconi syndrome (HP:0001994)2.06911221
86Abnormal lung lobation (HP:0002101)2.05807583
87Anorexia (HP:0002039)2.03313605
88Thrombocytosis (HP:0001894)2.03020692
89Abnormality of the labia minora (HP:0012880)2.02574520
90Progressive macrocephaly (HP:0004481)2.01956480
91Adrenal hypoplasia (HP:0000835)2.01649889
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01091116
93Neoplasm of the adrenal gland (HP:0100631)1.98560078
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.98449061
95Bone marrow hypocellularity (HP:0005528)1.98324352
96Prominent metopic ridge (HP:0005487)1.98276463
97Megaloblastic anemia (HP:0001889)1.96820264
98Petechiae (HP:0000967)1.96533071
99Cerebral edema (HP:0002181)1.95270891
100Reticulocytopenia (HP:0001896)1.94033045
101Type I transferrin isoform profile (HP:0003642)1.93574817
102Respiratory failure (HP:0002878)1.92666118
103Urticaria (HP:0001025)1.92437239
104Mitochondrial inheritance (HP:0001427)1.91745381
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.91153003
106Abnormality of the metopic suture (HP:0005556)1.91022232
107Axonal loss (HP:0003447)1.90992074
108Disinhibition (HP:0000734)1.90720668
109Apathy (HP:0000741)1.90297879
110Prolonged neonatal jaundice (HP:0006579)1.89121815
111Pustule (HP:0200039)1.87281635
112Pathologic fracture (HP:0002756)1.86879305
113Fasciculations (HP:0002380)1.86577741
114Tetraparesis (HP:0002273)1.86076878
115Abnormal trabecular bone morphology (HP:0100671)1.85288390
116Abnormality of nucleobase metabolism (HP:0010932)1.85223117
117Hyperglycinemia (HP:0002154)1.84571855
118Diminished motivation (HP:0000745)1.84553450
119Mediastinal lymphadenopathy (HP:0100721)1.84437487
120Oral leukoplakia (HP:0002745)1.84387752
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84336409
122Angiofibromas (HP:0010615)1.83870926
123Adenoma sebaceum (HP:0009720)1.83870926
124Recurrent viral infections (HP:0004429)1.83281383
125Meckel diverticulum (HP:0002245)1.82102870
126Cortical dysplasia (HP:0002539)1.81676651
127Premature ovarian failure (HP:0008209)1.81516770
128Recurrent fungal infections (HP:0002841)1.81486070
129Myositis (HP:0100614)1.79430015
130Gout (HP:0001997)1.79285578
131Dysphonia (HP:0001618)1.78153987
132Abnormality of glycine metabolism (HP:0010895)1.78147323
133Abnormality of serine family amino acid metabolism (HP:0010894)1.78147323
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78058412
135Progressive neurologic deterioration (HP:0002344)1.77477620
136Abnormality of the ileum (HP:0001549)1.77402344
137Posterior subcapsular cataract (HP:0007787)1.77247702
138Cervical subluxation (HP:0003308)1.77105556
139Delayed puberty (HP:0000823)1.74207787
140Increased serum lactate (HP:0002151)1.73781598
141Increased serum ferritin (HP:0003281)1.73481476
142Pancreatic islet-cell hyperplasia (HP:0004510)1.73217414
143Trismus (HP:0000211)1.73179973
144Sensorimotor neuropathy (HP:0007141)1.72890744
145Progressive muscle weakness (HP:0003323)1.72708395
146Selective tooth agenesis (HP:0001592)1.71289554
147Abnormality of iron homeostasis (HP:0011031)1.70977396
148Abnormality of lateral ventricle (HP:0030047)1.70865730
149Conjunctival telangiectasia (HP:0000524)1.70785989
150Abnormality of transition element cation homeostasis (HP:0011030)1.70683332
151Zonular cataract (HP:0010920)1.70570701
152Lymphoma (HP:0002665)1.69828360
153Upper limb muscle weakness (HP:0003484)1.69737994
154Lactic acidosis (HP:0003128)1.68908960
155Abnormal cartilage morphology (HP:0002763)1.68240268
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.67981928
157Pancytopenia (HP:0001876)1.67916073
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67648617
159Abnormality of the preputium (HP:0100587)1.67384808
160Astrocytoma (HP:0009592)1.67250841
161Abnormality of the astrocytes (HP:0100707)1.67250841
162Hypoplastic pelvis (HP:0008839)1.66933320
163Shoulder girdle muscle weakness (HP:0003547)1.66463846
164Neoplasm of the rectum (HP:0100743)1.65863435
165Progressive external ophthalmoplegia (HP:0000590)1.64116075
166Sparse eyelashes (HP:0000653)1.64010744
167Beaking of vertebral bodies (HP:0004568)1.63968935
168Exercise intolerance (HP:0003546)1.63712772
169Overlapping toe (HP:0001845)1.63094495
170Abnormal protein glycosylation (HP:0012346)1.61415390
171Abnormal glycosylation (HP:0012345)1.61415390
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61415390
173Abnormal protein N-linked glycosylation (HP:0012347)1.61415390
174Microglossia (HP:0000171)1.60278748
175CNS hypomyelination (HP:0003429)1.59650434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.23939130
2PBK4.05262939
3BUB13.49017853
4STK103.26263157
5CDC72.92646303
6BRSK22.60928232
7NEK12.60472072
8STK162.33489002
9EIF2AK12.27496622
10FLT32.27345852
11VRK22.16060770
12ERBB42.10717054
13ACVR1B2.08927358
14TSSK62.05623849
15NME22.04569860
16NEK21.97064900
17CDK121.81246670
18PIM21.81021761
19MAP3K81.74398786
20TTK1.68631680
21MAP4K11.67338833
22MAP2K31.60117044
23LIMK11.58612025
24BLK1.58288833
25PLK11.53719983
26EPHA21.53372207
27TESK21.52229951
28PAK41.49662968
29LRRK21.45631864
30TRIM281.42317391
31KIT1.40414173
32ATR1.33685166
33GRK61.32604414
34SRPK11.29597617
35MAP3K101.29000652
36PASK1.28106456
37SCYL21.26903030
38PIM11.25458506
39ZAP701.23266540
40ERN11.21316836
41CDK71.20921801
42CSNK1G31.20332579
43AKT31.18728690
44MKNK11.18328145
45CSNK1G11.18319623
46BCKDK1.18151100
47PLK31.17532055
48TYK21.16886342
49BRSK11.16159934
50EIF2AK31.15994788
51TBK11.15757894
52CDK41.09622288
53RPS6KA41.08972549
54MST1R1.05288304
55TESK11.05281451
56STK41.04858934
57IRAK31.01171593
58PLK41.00510706
59PTK20.99627564
60MAP3K30.99256338
61CSNK1G20.98636972
62MAP3K140.98228949
63RPS6KB20.98114661
64CSNK1A1L0.97743518
65CSF1R0.92414106
66BCR0.91832282
67LATS20.91563634
68TRIB30.89921990
69PDK20.89611785
70AURKB0.89243256
71ERBB30.88422803
72JAK30.88182566
73IRAK40.87277062
74ABL20.86096916
75TAOK30.85483353
76PKN20.85026770
77PDK30.84922546
78PDK40.84922546
79DYRK30.84505575
80TAF10.84235965
81TLK10.83805894
82MAP3K110.83058270
83MET0.82416011
84CLK10.81932164
85TGFBR10.81781185
86DAPK10.80792584
87MKNK20.79926029
88CCNB10.78835140
89PLK20.75092946
90MAP2K70.74217231
91MATK0.73929175
92CHEK20.73711850
93KDR0.72226938
94MST40.71030411
95PDGFRA0.70940327
96MAP3K40.70186655
97TGFBR20.68956396
98EPHA40.68806128
99SMG10.68552028
100STK30.67830805
101CHEK10.66628140
102RIPK10.65633502
103EPHB20.65591294
104AURKA0.64549571
105MAP3K120.64021204
106BTK0.63966204
107SYK0.63079533
108STK240.62101068
109TXK0.61689483
110CDK60.61575197
111PAK10.61160050
112IKBKB0.60152057
113ALK0.59713653
114CDK80.58170877
115MAP3K50.57956013
116STK38L0.56762820
117NEK90.56752646
118FGFR10.55283567
119VRK10.54242922
120EEF2K0.53432351
121CDK20.53129875
122NTRK10.52281967
123SIK30.51532729
124ATM0.50891897
125LYN0.49830917
126BMX0.49557462
127ZAK0.49358202
128CSNK2A10.49080323
129TAOK20.48803160
130PRKD30.48688557
131CDK140.47099884
132CAMK1D0.46840130
133TEC0.46386930
134LCK0.45537426
135BRAF0.45286742
136CDK180.45197980
137PRKCI0.45006243
138CSNK2A20.44473858
139ARAF0.44384750
140CSK0.43530243
141IRAK20.42664444
142CDK150.40385553
143MOS0.39846101
144ROCK20.39266065
145AKT20.39054372
146CDK11A0.38397597
147CSNK1E0.37305079
148FGFR20.37171674
149PAK20.36855935

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67903884
2Mismatch repair_Homo sapiens_hsa034303.20632582
3One carbon pool by folate_Homo sapiens_hsa006702.99552503
4Proteasome_Homo sapiens_hsa030502.84514338
5RNA polymerase_Homo sapiens_hsa030202.69698116
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63207642
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26643966
8RNA transport_Homo sapiens_hsa030132.19414348
9Fatty acid elongation_Homo sapiens_hsa000622.15589482
10Other glycan degradation_Homo sapiens_hsa005112.14923893
11Protein export_Homo sapiens_hsa030602.11844332
12Base excision repair_Homo sapiens_hsa034102.10517233
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06174797
14Nucleotide excision repair_Homo sapiens_hsa034202.02271252
15Homologous recombination_Homo sapiens_hsa034401.99564343
16Steroid biosynthesis_Homo sapiens_hsa001001.95764156
17Oxidative phosphorylation_Homo sapiens_hsa001901.88193152
18Pyrimidine metabolism_Homo sapiens_hsa002401.86845067
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85850247
20Antigen processing and presentation_Homo sapiens_hsa046121.85396695
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78304746
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.75855546
23Cell cycle_Homo sapiens_hsa041101.75154075
24Lysosome_Homo sapiens_hsa041421.74322952
25Spliceosome_Homo sapiens_hsa030401.70800900
26Biosynthesis of amino acids_Homo sapiens_hsa012301.62737624
27* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60615812
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51992816
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48682705
30Selenocompound metabolism_Homo sapiens_hsa004501.48387918
31Pentose phosphate pathway_Homo sapiens_hsa000301.45466838
32Parkinsons disease_Homo sapiens_hsa050121.43864108
33Vibrio cholerae infection_Homo sapiens_hsa051101.40552288
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.38717165
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37417775
36Carbon metabolism_Homo sapiens_hsa012001.36072582
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.34647515
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.27053683
39Ribosome_Homo sapiens_hsa030101.26155712
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25240579
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24873563
42Folate biosynthesis_Homo sapiens_hsa007901.24216143
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22683593
44Legionellosis_Homo sapiens_hsa051341.20531993
45Fructose and mannose metabolism_Homo sapiens_hsa000511.20234300
46p53 signaling pathway_Homo sapiens_hsa041151.18430003
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17081719
48Staphylococcus aureus infection_Homo sapiens_hsa051501.15982700
49Fanconi anemia pathway_Homo sapiens_hsa034601.15803413
50Huntingtons disease_Homo sapiens_hsa050161.14206682
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12872418
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12577624
53Propanoate metabolism_Homo sapiens_hsa006401.10897051
54Non-homologous end-joining_Homo sapiens_hsa034501.09689467
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07351565
56N-Glycan biosynthesis_Homo sapiens_hsa005101.06734405
57Epstein-Barr virus infection_Homo sapiens_hsa051691.01613721
58Galactose metabolism_Homo sapiens_hsa000520.99118372
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96706298
60RNA degradation_Homo sapiens_hsa030180.91427522
61Basal transcription factors_Homo sapiens_hsa030220.90889509
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88344103
63Alzheimers disease_Homo sapiens_hsa050100.86643789
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86195729
65Sulfur metabolism_Homo sapiens_hsa009200.83161083
66Sphingolipid metabolism_Homo sapiens_hsa006000.82960815
67Renin-angiotensin system_Homo sapiens_hsa046140.81823778
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80663487
69Herpes simplex infection_Homo sapiens_hsa051680.79670576
70Glutathione metabolism_Homo sapiens_hsa004800.78656420
71Leishmaniasis_Homo sapiens_hsa051400.76733866
72Purine metabolism_Homo sapiens_hsa002300.76626539
73Apoptosis_Homo sapiens_hsa042100.76092675
74Vitamin B6 metabolism_Homo sapiens_hsa007500.75649716
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.70265578
76Collecting duct acid secretion_Homo sapiens_hsa049660.69304371
77Fatty acid metabolism_Homo sapiens_hsa012120.69088817
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68554636
79Measles_Homo sapiens_hsa051620.66968512
80Graft-versus-host disease_Homo sapiens_hsa053320.66115191
81Viral carcinogenesis_Homo sapiens_hsa052030.64012295
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.63023449
83Oocyte meiosis_Homo sapiens_hsa041140.62842987
84Vitamin digestion and absorption_Homo sapiens_hsa049770.61656749
85Regulation of autophagy_Homo sapiens_hsa041400.59759070
86Tuberculosis_Homo sapiens_hsa051520.58029087
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57582837
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57190570
89Pyruvate metabolism_Homo sapiens_hsa006200.56595227
90Phagosome_Homo sapiens_hsa041450.55584621
91Hippo signaling pathway_Homo sapiens_hsa043900.54209923
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53426246
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.52280676
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.51569479
95Allograft rejection_Homo sapiens_hsa053300.51051401
96Primary immunodeficiency_Homo sapiens_hsa053400.51011257
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49516777
98Peroxisome_Homo sapiens_hsa041460.47793123
99mRNA surveillance pathway_Homo sapiens_hsa030150.47103919
100Shigellosis_Homo sapiens_hsa051310.44802711
101Sulfur relay system_Homo sapiens_hsa041220.44365969
102Rheumatoid arthritis_Homo sapiens_hsa053230.44021419
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43880292
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43472343
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41911352
106Influenza A_Homo sapiens_hsa051640.41492880
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40786444
108Fatty acid degradation_Homo sapiens_hsa000710.40731630
109Complement and coagulation cascades_Homo sapiens_hsa046100.39489260
110TGF-beta signaling pathway_Homo sapiens_hsa043500.38893397
111Tryptophan metabolism_Homo sapiens_hsa003800.38483917
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38469674
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38377016
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38163459
115Arginine and proline metabolism_Homo sapiens_hsa003300.37573169
116Synaptic vesicle cycle_Homo sapiens_hsa047210.37394903
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36200705
118* Metabolic pathways_Homo sapiens_hsa011000.36189539
119Adherens junction_Homo sapiens_hsa045200.35459144
120Lysine degradation_Homo sapiens_hsa003100.35254244
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35019457
122Arginine biosynthesis_Homo sapiens_hsa002200.32008590
123Basal cell carcinoma_Homo sapiens_hsa052170.31874698
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31273227
125Osteoclast differentiation_Homo sapiens_hsa043800.31060917
126Starch and sucrose metabolism_Homo sapiens_hsa005000.30738713
127Mineral absorption_Homo sapiens_hsa049780.30511399
128beta-Alanine metabolism_Homo sapiens_hsa004100.26645157
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26444371
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25205212
131Phenylalanine metabolism_Homo sapiens_hsa003600.24990090
132Pertussis_Homo sapiens_hsa051330.24332418
133Thyroid cancer_Homo sapiens_hsa052160.21829116
134Tight junction_Homo sapiens_hsa045300.19669178

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