GNPDA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid nucleus differentiation (GO:0007289)4.51327759
2protein neddylation (GO:0045116)4.38674008
3axon ensheathment in central nervous system (GO:0032291)4.28177482
4central nervous system myelination (GO:0022010)4.28177482
5retinal cone cell development (GO:0046549)4.23071547
6prenylation (GO:0097354)4.13191972
7protein prenylation (GO:0018342)4.13191972
8regulation of meiosis I (GO:0060631)4.07505029
9positive regulation of dendritic spine morphogenesis (GO:0061003)4.00986378
10meiotic cell cycle (GO:0051321)3.75047048
11long-chain fatty acid biosynthetic process (GO:0042759)3.73073524
12DNA double-strand break processing (GO:0000729)3.72431411
13attachment of spindle microtubules to kinetochore (GO:0008608)3.66992169
14regulation of DNA methylation (GO:0044030)3.61179937
15piRNA metabolic process (GO:0034587)3.48920461
16fatty acid elongation (GO:0030497)3.47572236
17negative regulation of neurotransmitter transport (GO:0051589)3.32047718
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.31416038
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31416038
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31416038
21mannosylation (GO:0097502)3.27029688
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23269089
23relaxation of smooth muscle (GO:0044557)3.22878376
24protein localization to cilium (GO:0061512)3.22375061
25synapsis (GO:0007129)3.21119238
26signal peptide processing (GO:0006465)3.20389226
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.09583772
28negative regulation of neurotransmitter secretion (GO:0046929)3.08065235
29protein complex biogenesis (GO:0070271)3.07646841
30negative regulation of execution phase of apoptosis (GO:1900118)3.07286386
31neural tube formation (GO:0001841)3.05297050
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.05176935
33nonmotile primary cilium assembly (GO:0035058)3.04553704
34GPI anchor biosynthetic process (GO:0006506)3.02526783
35eye photoreceptor cell differentiation (GO:0001754)3.00709751
36photoreceptor cell differentiation (GO:0046530)3.00709751
37chaperone-mediated protein transport (GO:0072321)3.00207562
38microtubule anchoring (GO:0034453)2.97686585
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96294310
40single strand break repair (GO:0000012)2.94920229
41mitochondrial respiratory chain complex I assembly (GO:0032981)2.93617629
42NADH dehydrogenase complex assembly (GO:0010257)2.93617629
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93617629
44postreplication repair (GO:0006301)2.91678762
45somite rostral/caudal axis specification (GO:0032525)2.91370685
46oocyte development (GO:0048599)2.90873360
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89995728
48ribosome assembly (GO:0042255)2.89980435
49regulation of DNA endoreduplication (GO:0032875)2.88024032
50aggressive behavior (GO:0002118)2.87744999
51protein localization to chromosome (GO:0034502)2.87464528
52protein localization to kinetochore (GO:0034501)2.86514002
53response to redox state (GO:0051775)2.86386799
54gene silencing by RNA (GO:0031047)2.85515084
55female gamete generation (GO:0007292)2.84314252
56translesion synthesis (GO:0019985)2.83073041
57regulation of acrosome reaction (GO:0060046)2.81992896
58positive regulation of histone H3-K4 methylation (GO:0051571)2.80293413
59pyrimidine dimer repair (GO:0006290)2.79495098
60regulation of cell maturation (GO:1903429)2.78848215
61acrosome assembly (GO:0001675)2.74605981
62intraciliary transport (GO:0042073)2.73427715
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72858542
64nucleotide transmembrane transport (GO:1901679)2.72577881
65neutrophil activation involved in immune response (GO:0002283)2.71432228
66CENP-A containing nucleosome assembly (GO:0034080)2.69783370
67regulation of Golgi to plasma membrane protein transport (GO:0042996)2.68778813
68regulation of dendritic spine morphogenesis (GO:0061001)2.68151750
69presynaptic membrane assembly (GO:0097105)2.67080630
70mitochondrial respiratory chain complex assembly (GO:0033108)2.65435241
71inositol phosphate catabolic process (GO:0071545)2.62445910
72positive regulation of interleukin-17 production (GO:0032740)2.60848311
73rRNA catabolic process (GO:0016075)2.60549430
74cellular response to interleukin-15 (GO:0071350)2.59519840
75replication fork processing (GO:0031297)2.56347824
76regulation of axon regeneration (GO:0048679)2.54879598
77regulation of neuron projection regeneration (GO:0070570)2.54879598
78GPI anchor metabolic process (GO:0006505)2.54722872
79myelination (GO:0042552)2.53759397
80DNA methylation involved in gamete generation (GO:0043046)2.53680350
81male meiosis (GO:0007140)2.53183287
82presynaptic membrane organization (GO:0097090)2.53104186
83chromosome organization involved in meiosis (GO:0070192)2.50561332
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48826126
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47576848
86regulation of cilium movement (GO:0003352)2.46827673
87peripheral nervous system neuron development (GO:0048935)2.46418863
88neurofilament cytoskeleton organization (GO:0060052)2.45972969
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45669515
90inositol phosphate dephosphorylation (GO:0046855)2.45669515
91axoneme assembly (GO:0035082)2.45188046
92cullin deneddylation (GO:0010388)2.44021874
93glycosphingolipid biosynthetic process (GO:0006688)2.43595696
94DNA replication-dependent nucleosome assembly (GO:0006335)2.43465022
95DNA replication-dependent nucleosome organization (GO:0034723)2.43465022
96chromatin remodeling at centromere (GO:0031055)2.43316974
97ensheathment of neurons (GO:0007272)2.43205414
98axon ensheathment (GO:0008366)2.43205414
99male meiosis I (GO:0007141)2.42688506
100protein localization to chromosome, centromeric region (GO:0071459)2.42489395
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42083069
102central nervous system projection neuron axonogenesis (GO:0021952)2.41889127
103protein polyglutamylation (GO:0018095)2.41474614
104central nervous system neuron axonogenesis (GO:0021955)2.40840580
105protein deneddylation (GO:0000338)2.40467809
106establishment of melanosome localization (GO:0032401)2.40023233
107positive regulation of defense response to virus by host (GO:0002230)2.39663646
108regulation of protein targeting to membrane (GO:0090313)2.39437546
109regulation of T cell mediated cytotoxicity (GO:0001914)2.39290189
110positive regulation of action potential (GO:0045760)2.39281734
111RNA destabilization (GO:0050779)2.38829765
112layer formation in cerebral cortex (GO:0021819)2.38312604
113phenol-containing compound catabolic process (GO:0019336)2.38137233
114protein K6-linked ubiquitination (GO:0085020)2.36820658
115nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35718195
116histone exchange (GO:0043486)2.35683530
117establishment of pigment granule localization (GO:0051905)2.34743391
118positive regulation of mitochondrial fission (GO:0090141)2.34483797
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34290498
120neuron fate determination (GO:0048664)2.33203487
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.31624838
122phagosome maturation (GO:0090382)2.31179653
123adenosine metabolic process (GO:0046085)2.30905910
124developmental pigmentation (GO:0048066)2.30845995
125regulation of chromatin silencing (GO:0031935)2.30708170
126cilium morphogenesis (GO:0060271)2.30699752
127cellular response to interferon-beta (GO:0035458)2.30549590
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30369718
129dendrite morphogenesis (GO:0048813)2.30302303
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.29440478
131preassembly of GPI anchor in ER membrane (GO:0016254)2.28410048
132double-strand break repair via homologous recombination (GO:0000724)2.28061445
133amyloid precursor protein metabolic process (GO:0042982)2.27888014
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27886293
135protein K11-linked ubiquitination (GO:0070979)2.27603355
136C-terminal protein amino acid modification (GO:0018410)2.27594047
137regulation of memory T cell differentiation (GO:0043380)2.27527386
138histone H2A acetylation (GO:0043968)2.27101159
139mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.27090800
140positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.27090800
141recombinational repair (GO:0000725)2.26347741
142regulation of female gonad development (GO:2000194)2.25041722
143negative regulation of JUN kinase activity (GO:0043508)2.24555152
144sister chromatid cohesion (GO:0007062)2.24413560
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.23617965
146sequestering of actin monomers (GO:0042989)2.23372918
147neuronal action potential propagation (GO:0019227)2.23011028
148neuron cell-cell adhesion (GO:0007158)2.22783049
149positive regulation of chromosome segregation (GO:0051984)2.22329047
150mitochondrial calcium ion homeostasis (GO:0051560)2.22020470
151viral protein processing (GO:0019082)2.21988533
152DNA ligation (GO:0006266)2.21336995
153respiratory chain complex IV assembly (GO:0008535)2.21187324
154regulation of meiosis (GO:0040020)2.21011044
155meiotic cell cycle process (GO:1903046)2.20970958
156positive regulation of vesicle fusion (GO:0031340)2.20831370
157substantia nigra development (GO:0021762)2.20718045
158melanosome transport (GO:0032402)2.20631997
159cAMP catabolic process (GO:0006198)2.20525761
160transferrin transport (GO:0033572)2.20522499
161regulation of isotype switching to IgG isotypes (GO:0048302)2.20421971
162righting reflex (GO:0060013)2.20278744
163startle response (GO:0001964)2.19935089
164regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.19746458
165mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.19402776
166centriole replication (GO:0007099)2.19303958
167DNA catabolic process, exonucleolytic (GO:0000738)2.18780091
168regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.18720331
169regulation of collateral sprouting (GO:0048670)2.17470703
170positive regulation of meiosis (GO:0045836)2.17338816
171protein ADP-ribosylation (GO:0006471)2.16372253
172deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.16153608
173vascular smooth muscle contraction (GO:0014829)2.16142410
174pigment granule transport (GO:0051904)2.16024126
175proteasome assembly (GO:0043248)2.15858421
176cytochrome complex assembly (GO:0017004)2.15739484
177regulation of interleukin-17 production (GO:0032660)2.14605611
178positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.13836297
179regulation of activation of Janus kinase activity (GO:0010533)2.13779690
180microtubule severing (GO:0051013)2.12992252
181C-terminal protein lipidation (GO:0006501)2.12846734
182positive regulation of cell fate commitment (GO:0010455)2.10616762
183RNA capping (GO:0036260)2.09023764
1847-methylguanosine RNA capping (GO:0009452)2.09023764
185multicellular organism reproduction (GO:0032504)2.08970683
186response to interferon-beta (GO:0035456)2.08901613
1877-methylguanosine mRNA capping (GO:0006370)2.08849421
188activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.08547173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65210930
2GBX2_23144817_ChIP-Seq_PC3_Human3.14548459
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04901745
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.86266373
5TAF15_26573619_Chip-Seq_HEK293_Human2.84331097
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67841539
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62131880
8* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50335713
9ZNF274_21170338_ChIP-Seq_K562_Hela2.39309406
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26182747
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24822198
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.09268153
13FUS_26573619_Chip-Seq_HEK293_Human2.07679496
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.04408115
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.01569451
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99357430
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91112295
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90636006
19VDR_22108803_ChIP-Seq_LS180_Human1.89159862
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88811450
21P300_19829295_ChIP-Seq_ESCs_Human1.87737606
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87473652
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83690285
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80946519
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80682407
26* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80550394
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79993965
28ER_23166858_ChIP-Seq_MCF-7_Human1.75456437
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.64713990
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62256216
31* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61728409
32* CBP_20019798_ChIP-Seq_JUKART_Human1.61728409
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61723583
34EZH2_22144423_ChIP-Seq_EOC_Human1.60495905
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59414944
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56873206
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56825159
38AR_25329375_ChIP-Seq_VCAP_Human1.55845728
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52459476
40EWS_26573619_Chip-Seq_HEK293_Human1.50028842
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49791611
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.47559644
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44878609
44RNF2_27304074_Chip-Seq_NSC_Mouse1.44188574
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.44031908
46SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43508705
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.43487512
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.43362376
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42602149
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40619563
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.40384239
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.37778830
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37692519
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.36390648
55TCF4_23295773_ChIP-Seq_U87_Human1.36383881
56IGF1R_20145208_ChIP-Seq_DFB_Human1.36038734
57SMAD4_21799915_ChIP-Seq_A2780_Human1.35801145
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35609955
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35580501
60* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35191218
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34881103
62* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33795019
63P53_22387025_ChIP-Seq_ESCs_Mouse1.33776176
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32137705
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31397264
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.31014061
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30796716
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28995108
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28734637
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.28311350
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28255468
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27222141
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.27138918
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26489030
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26447531
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.25990845
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.25309899
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24969776
79P300_18555785_Chip-Seq_ESCs_Mouse1.24347615
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24138995
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24019986
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23551714
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21933339
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21435739
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.19390783
86ELK1_19687146_ChIP-ChIP_HELA_Human1.17788115
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17562870
88RUNX2_22187159_ChIP-Seq_PCA_Human1.16661454
89MYC_18940864_ChIP-ChIP_HL60_Human1.14412282
90* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14115182
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14050903
92* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13617310
93JUN_21703547_ChIP-Seq_K562_Human1.13097718
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.13039565
95BCAT_22108803_ChIP-Seq_LS180_Human1.13026509
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12770476
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12374850
98TCF4_22108803_ChIP-Seq_LS180_Human1.12331863
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12288212
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.11792643
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.11677933
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11649266
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.11347102
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10920062
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10797037
106BP1_19119308_ChIP-ChIP_Hs578T_Human1.10151102
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09870260
108VDR_23849224_ChIP-Seq_CD4+_Human1.09568415
109IRF1_19129219_ChIP-ChIP_H3396_Human1.08131393
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08130700
111KDM2B_26808549_Chip-Seq_REH_Human1.07837844
112KLF4_18555785_Chip-Seq_ESCs_Mouse1.06646147
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06537413
114* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06292530
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.06180512
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05809354
117* SOX2_19829295_ChIP-Seq_ESCs_Human1.05718674
118* NANOG_19829295_ChIP-Seq_ESCs_Human1.05718674
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04832879
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.04199601
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03934640
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03708469
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03581956
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.03182382
125* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02508323
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01911747
127CTCF_18555785_Chip-Seq_ESCs_Mouse1.01898626
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01478585
129JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01088550
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00574917
131TP53_22573176_ChIP-Seq_HFKS_Human1.00530258
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.00499740
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00139507
134STAT3_23295773_ChIP-Seq_U87_Human0.99659107
135RUNX_20019798_ChIP-Seq_JUKART_Human0.99446554
136CDX2_22108803_ChIP-Seq_LS180_Human0.99042076
137ZFX_18555785_Chip-Seq_ESCs_Mouse0.98360928
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97965978
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97965978
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97503799
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.97173373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect3.63707540
2MP0008058_abnormal_DNA_repair2.91337256
3MP0008057_abnormal_DNA_replication2.82337810
4MP0001905_abnormal_dopamine_level2.73428949
5MP0001986_abnormal_taste_sensitivity2.72962141
6MP0002234_abnormal_pharynx_morphology2.72776414
7MP0000372_irregular_coat_pigmentation2.67289815
8MP0001529_abnormal_vocalization2.63559464
9MP0005394_taste/olfaction_phenotype2.58277803
10MP0005499_abnormal_olfactory_system2.58277803
11MP0009780_abnormal_chondrocyte_physiolo2.54117345
12MP0005171_absent_coat_pigmentation2.47936002
13MP0003880_abnormal_central_pattern2.43193180
14MP0003890_abnormal_embryonic-extraembry2.35395724
15MP0010386_abnormal_urinary_bladder2.34998999
16MP0001984_abnormal_olfaction2.33101798
17MP0005671_abnormal_response_to2.30560591
18MP0005645_abnormal_hypothalamus_physiol2.26744012
19MP0005646_abnormal_pituitary_gland2.23656786
20MP0000920_abnormal_myelination2.15229141
21MP0004270_analgesia2.10534895
22MP0003136_yellow_coat_color2.01049533
23MP0004859_abnormal_synaptic_plasticity1.98757901
24MP0002735_abnormal_chemical_nociception1.98329419
25MP0002272_abnormal_nervous_system1.96684381
26MP0002734_abnormal_mechanical_nocicepti1.91995961
27MP0001968_abnormal_touch/_nociception1.91359493
28MP0002837_dystrophic_cardiac_calcinosis1.90795211
29MP0002736_abnormal_nociception_after1.87335756
30MP0002638_abnormal_pupillary_reflex1.85391845
31MP0009785_altered_susceptibility_to1.79686057
32MP0002163_abnormal_gland_morphology1.75105544
33MP0001188_hyperpigmentation1.70470741
34MP0001485_abnormal_pinna_reflex1.67971534
35MP0001835_abnormal_antigen_presentation1.63962791
36MP0006276_abnormal_autonomic_nervous1.62577414
37MP0005379_endocrine/exocrine_gland_phen1.61535424
38MP0009046_muscle_twitch1.56106512
39MP0008877_abnormal_DNA_methylation1.55860005
40MP0009697_abnormal_copulation1.54621937
41MP0003121_genomic_imprinting1.53527785
42MP0005410_abnormal_fertilization1.52413763
43MP0004142_abnormal_muscle_tone1.52412001
44MP0000569_abnormal_digit_pigmentation1.51646134
45MP0008775_abnormal_heart_ventricle1.50768041
46MP0003183_abnormal_peptide_metabolism1.49618515
47MP0003787_abnormal_imprinting1.47622099
48MP0005310_abnormal_salivary_gland1.47262397
49MP0010094_abnormal_chromosome_stability1.45924878
50MP0001970_abnormal_pain_threshold1.45357126
51MP0003950_abnormal_plasma_membrane1.44079934
52MP0002064_seizures1.42169277
53MP0001486_abnormal_startle_reflex1.41657879
54MP0002148_abnormal_hypersensitivity_rea1.39846829
55MP0004742_abnormal_vestibular_system1.38402154
56MP0000015_abnormal_ear_pigmentation1.38128025
57MP0006292_abnormal_olfactory_placode1.34925178
58MP0009745_abnormal_behavioral_response1.34852350
59MP0005187_abnormal_penis_morphology1.34448784
60MP0001929_abnormal_gametogenesis1.33986657
61MP0004885_abnormal_endolymph1.32842602
62MP0003763_abnormal_thymus_physiology1.32483833
63MP0005395_other_phenotype1.31410894
64MP0003724_increased_susceptibility_to1.28657928
65MP0000427_abnormal_hair_cycle1.28617575
66MP0004215_abnormal_myocardial_fiber1.25746246
67MP0008260_abnormal_autophagy1.24943091
68MP0002733_abnormal_thermal_nociception1.22142224
69MP0002067_abnormal_sensory_capabilities1.20117821
70MP0002572_abnormal_emotion/affect_behav1.19991394
71MP0005000_abnormal_immune_tolerance1.17358724
72MP0002210_abnormal_sex_determination1.16742126
73MP0003635_abnormal_synaptic_transmissio1.15449805
74MP0005409_darkened_coat_color1.12953808
75MP0010234_abnormal_vibrissa_follicle1.12739874
76MP0002233_abnormal_nose_morphology1.12688858
77MP0002009_preneoplasia1.11390191
78MP0002102_abnormal_ear_morphology1.10517125
79MP0001502_abnormal_circadian_rhythm1.09367506
80MP0001501_abnormal_sleep_pattern1.08014046
81MP0002876_abnormal_thyroid_physiology1.06046202
82MP0006072_abnormal_retinal_apoptosis1.05375090
83MP0005551_abnormal_eye_electrophysiolog1.04281501
84MP0002184_abnormal_innervation1.04222982
85MP0004811_abnormal_neuron_physiology1.02460728
86MP0009333_abnormal_splenocyte_physiolog1.01615361
87MP0003634_abnormal_glial_cell1.01297712
88MP0004924_abnormal_behavior1.01168818
89MP0005386_behavior/neurological_phenoty1.01168818
90MP0000653_abnormal_sex_gland1.01142057
91MP0002229_neurodegeneration0.99982468
92MP0008569_lethality_at_weaning0.94287011
93MP0002822_catalepsy0.94028071
94MP0008932_abnormal_embryonic_tissue0.93623899
95MP0002420_abnormal_adaptive_immunity0.93549439
96MP0002723_abnormal_immune_serum0.93509748
97MP0003786_premature_aging0.93409682
98MP0002751_abnormal_autonomic_nervous0.93323215
99MP0003699_abnormal_female_reproductive0.93269129
100MP0006082_CNS_inflammation0.93246107
101MP0001819_abnormal_immune_cell0.92925316
102MP0001963_abnormal_hearing_physiology0.92785008
103MP0001440_abnormal_grooming_behavior0.92703366
104MP0003698_abnormal_male_reproductive0.92083777
105MP0002090_abnormal_vision0.91891379
106MP0001177_atelectasis0.91187847
107MP0000631_abnormal_neuroendocrine_gland0.90095776
108MP0005084_abnormal_gallbladder_morpholo0.89341007
109MP0003077_abnormal_cell_cycle0.89250563
110MP0004084_abnormal_cardiac_muscle0.89003277
111MP0002160_abnormal_reproductive_system0.88980354
112MP0005387_immune_system_phenotype0.87966884
113MP0001790_abnormal_immune_system0.87966884
114MP0000685_abnormal_immune_system0.87678820
115MP0003879_abnormal_hair_cell0.87660273
116MP0000778_abnormal_nervous_system0.87399928
117MP0002752_abnormal_somatic_nervous0.86330593
118MP0005025_abnormal_response_to0.86192555
119MP0002882_abnormal_neuron_morphology0.85278640
120MP0004147_increased_porphyrin_level0.84868138
121MP0002095_abnormal_skin_pigmentation0.84661298
122MP0002161_abnormal_fertility/fecundity0.84086375
123MP0003329_amyloid_beta_deposits0.83697972
124MP0005253_abnormal_eye_physiology0.83057361
125MP0003755_abnormal_palate_morphology0.83006001
126MP0002452_abnormal_antigen_presenting0.81860640
127MP0002419_abnormal_innate_immunity0.81025717
128MP0006054_spinal_hemorrhage0.80401283
129MP0001145_abnormal_male_reproductive0.79224784
130MP0002938_white_spotting0.78739772
131MP0005408_hypopigmentation0.78733187
132MP0002063_abnormal_learning/memory/cond0.77630883
133MP0004134_abnormal_chest_morphology0.77598584
134MP0000955_abnormal_spinal_cord0.77506165
135MP0003631_nervous_system_phenotype0.75260144
136MP0002177_abnormal_outer_ear0.75240861
137MP0002557_abnormal_social/conspecific_i0.75191572
138MP0003633_abnormal_nervous_system0.74702352
139MP0008789_abnormal_olfactory_epithelium0.74615408
140MP0001346_abnormal_lacrimal_gland0.73857165
141MP0005075_abnormal_melanosome_morpholog0.73516014
142MP0000049_abnormal_middle_ear0.70737499
143MP0001293_anophthalmia0.70071247
144MP0000013_abnormal_adipose_tissue0.69190047
145MP0004085_abnormal_heartbeat0.69095997
146MP0003937_abnormal_limbs/digits/tail_de0.68366993
147MP0005423_abnormal_somatic_nervous0.68318619
148MP0002066_abnormal_motor_capabilities/c0.65957126
149MP0010678_abnormal_skin_adnexa0.65566746
150MP0001299_abnormal_eye_distance/0.65059152

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.56955221
2Medial flaring of the eyebrow (HP:0010747)3.88228709
3Papillary thyroid carcinoma (HP:0002895)3.55510262
4Nephrogenic diabetes insipidus (HP:0009806)3.54841817
5Congenital primary aphakia (HP:0007707)3.46891655
6Gait imbalance (HP:0002141)3.43947469
7Parakeratosis (HP:0001036)3.43817414
8Acute necrotizing encephalopathy (HP:0006965)3.35810857
9Supernumerary spleens (HP:0009799)3.23363377
10Pheochromocytoma (HP:0002666)3.14628930
11Neuroendocrine neoplasm (HP:0100634)3.13693934
12Oligodactyly (hands) (HP:0001180)3.13363621
13Short tibia (HP:0005736)3.10854761
14Mitochondrial inheritance (HP:0001427)3.10271995
15Abnormal mitochondria in muscle tissue (HP:0008316)3.00053589
16Hepatocellular necrosis (HP:0001404)2.96271296
17Fair hair (HP:0002286)2.93079692
18Abnormal hair whorl (HP:0010721)2.92441461
19Genital tract atresia (HP:0001827)2.88204571
20Progressive macrocephaly (HP:0004481)2.83298523
21Vaginal atresia (HP:0000148)2.83268352
22Abnormality of the labia minora (HP:0012880)2.81586675
23Metaphyseal dysplasia (HP:0100255)2.79670637
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77146929
25Gaze-evoked nystagmus (HP:0000640)2.71854636
26Patchy hypopigmentation of hair (HP:0011365)2.67733587
27Atonic seizures (HP:0010819)2.63833712
28Type I transferrin isoform profile (HP:0003642)2.62736144
29Retinal dysplasia (HP:0007973)2.61489568
30Increased CSF lactate (HP:0002490)2.56063594
31Poor coordination (HP:0002370)2.55634001
32Renal Fanconi syndrome (HP:0001994)2.53429618
33Absent/shortened dynein arms (HP:0200106)2.52175710
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.52175710
35Autoamputation (HP:0001218)2.51433451
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.51122327
37Thyroid carcinoma (HP:0002890)2.50731763
38Increased hepatocellular lipid droplets (HP:0006565)2.44139783
39Aplasia/Hypoplasia of the lens (HP:0008063)2.40591628
40Facial hemangioma (HP:0000329)2.39327260
41Abnormal ciliary motility (HP:0012262)2.37888826
42Increased IgM level (HP:0003496)2.37697353
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35663420
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.35663420
45Drooling (HP:0002307)2.35518410
46Optic neuritis (HP:0100653)2.35378576
47Retrobulbar optic neuritis (HP:0100654)2.35378576
48Renal cortical cysts (HP:0000803)2.34546690
49Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.34210814
50Pancreatic fibrosis (HP:0100732)2.33418996
513-Methylglutaconic aciduria (HP:0003535)2.30253036
52Abnormal respiratory motile cilium morphology (HP:0005938)2.27970335
53Abnormal respiratory epithelium morphology (HP:0012253)2.27970335
54Acute encephalopathy (HP:0006846)2.27695978
55Median cleft lip (HP:0000161)2.26534451
56Abnormal respiratory motile cilium physiology (HP:0012261)2.25241784
57Type 2 muscle fiber atrophy (HP:0003554)2.24094072
58Hepatic necrosis (HP:0002605)2.23405679
59Abnormal protein glycosylation (HP:0012346)2.23256056
60Abnormal glycosylation (HP:0012345)2.23256056
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23256056
62Abnormal protein N-linked glycosylation (HP:0012347)2.23256056
63White forelock (HP:0002211)2.22657592
64Volvulus (HP:0002580)2.21433103
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16980047
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16887420
67Anterior segment dysgenesis (HP:0007700)2.16178150
68Abnormality of the fovea (HP:0000493)2.15815587
69Hemiparesis (HP:0001269)2.14994089
70Sensory axonal neuropathy (HP:0003390)2.13769272
71Chronic otitis media (HP:0000389)2.12847170
72Intestinal atresia (HP:0011100)2.12777400
73True hermaphroditism (HP:0010459)2.12247594
74Chromsome breakage (HP:0040012)2.12184021
75Thyroid-stimulating hormone excess (HP:0002925)2.11914489
76Myositis (HP:0100614)2.10975261
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.08709724
78Hypoplasia of the fovea (HP:0007750)2.08709724
79Abnormality of chromosome stability (HP:0003220)2.08293543
80Constricted visual fields (HP:0001133)2.06463113
81Broad foot (HP:0001769)2.04892333
82Widely spaced teeth (HP:0000687)2.04623277
83Excessive salivation (HP:0003781)2.04579827
84Gonadotropin excess (HP:0000837)2.00435465
85Broad-based gait (HP:0002136)1.99738480
86Lipid accumulation in hepatocytes (HP:0006561)1.97769590
87Leukodystrophy (HP:0002415)1.97543424
88Progressive inability to walk (HP:0002505)1.97488264
89Truncal ataxia (HP:0002078)1.97068114
90Choroideremia (HP:0001139)1.95172734
91IgG deficiency (HP:0004315)1.94279298
92Thyroiditis (HP:0100646)1.93159833
93Epileptic encephalopathy (HP:0200134)1.93133379
94Action tremor (HP:0002345)1.92913664
95Optic nerve hypoplasia (HP:0000609)1.92087149
96Febrile seizures (HP:0002373)1.91956986
97Tubulointerstitial nephritis (HP:0001970)1.91328320
98Neurofibrillary tangles (HP:0002185)1.89937498
99Abnormality of T cell number (HP:0011839)1.88219772
100Neonatal respiratory distress (HP:0002643)1.87676877
101Hyperventilation (HP:0002883)1.86936720
102Abnormality of the renal medulla (HP:0100957)1.86798512
103Focal seizures (HP:0007359)1.86720984
104Azoospermia (HP:0000027)1.85378126
105Generalized hypopigmentation of hair (HP:0011358)1.84244970
106Abnormality of the metopic suture (HP:0005556)1.83667887
107Postaxial foot polydactyly (HP:0001830)1.83475380
108Focal motor seizures (HP:0011153)1.82567415
109Polyphagia (HP:0002591)1.81903014
110Colon cancer (HP:0003003)1.80678032
111Epileptiform EEG discharges (HP:0011182)1.80649246
112Cystic hygroma (HP:0000476)1.80305996
113Hypsarrhythmia (HP:0002521)1.80066610
114Abnormality of midbrain morphology (HP:0002418)1.79804325
115Molar tooth sign on MRI (HP:0002419)1.79804325
116Medulloblastoma (HP:0002885)1.79617177
117Oligodactyly (HP:0012165)1.78700409
118Abnormality of renal resorption (HP:0011038)1.78670595
119Optic disc pallor (HP:0000543)1.78088714
120T lymphocytopenia (HP:0005403)1.77843723
121EEG with generalized epileptiform discharges (HP:0011198)1.77573332
122Stillbirth (HP:0003826)1.76608334
123Prominent metopic ridge (HP:0005487)1.76116972
124Attenuation of retinal blood vessels (HP:0007843)1.76112020
125Absent speech (HP:0001344)1.75885085
126Pancreatic cysts (HP:0001737)1.75619987
127Abnormality of the corticospinal tract (HP:0002492)1.75467689
128Cerebral hypomyelination (HP:0006808)1.75292273
129Limb dystonia (HP:0002451)1.75092616
130Abnormality of the musculature of the pelvis (HP:0001469)1.74501194
131Abnormality of the hip-girdle musculature (HP:0001445)1.74501194
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73697519
133Muscle fiber atrophy (HP:0100295)1.73576899
134Xerostomia (HP:0000217)1.73405490
135Severe combined immunodeficiency (HP:0004430)1.72907894
136Chronic sinusitis (HP:0011109)1.72076537
137Pachygyria (HP:0001302)1.72070325
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.71991909
139Abnormality of B cell number (HP:0010975)1.71788954
140B lymphocytopenia (HP:0010976)1.71788954
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.70333969
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69556787
143Nephronophthisis (HP:0000090)1.69371615
144Postaxial hand polydactyly (HP:0001162)1.69266644
145Chronic hepatic failure (HP:0100626)1.69239598
146Lissencephaly (HP:0001339)1.68227499
147CNS hypomyelination (HP:0003429)1.68161773
148Small hand (HP:0200055)1.67774013
149Abnormal eating behavior (HP:0100738)1.67469019
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67068216
151Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67068216
152Methylmalonic acidemia (HP:0002912)1.67009037
153Oculomotor apraxia (HP:0000657)1.66994297
154Glioma (HP:0009733)1.66483966
155Recurrent bronchitis (HP:0002837)1.65702848
156Abnormal auditory evoked potentials (HP:0006958)1.65346507
157Orchitis (HP:0100796)1.65152449
158Bifid tongue (HP:0010297)1.64741620
159Abnormality of the renal cortex (HP:0011035)1.64699615
160Abnormality of glycolysis (HP:0004366)1.64173694
161Increased serum pyruvate (HP:0003542)1.64173694
162Nonprogressive disorder (HP:0003680)1.63877957
163Exertional dyspnea (HP:0002875)1.63650074
164Abnormal lung lobation (HP:0002101)1.63327857
165Purpura (HP:0000979)1.63159376
166Hypoproteinemia (HP:0003075)1.62107570
167Abnormality of abdominal situs (HP:0011620)1.62051953
168Abdominal situs inversus (HP:0003363)1.62051953
169Rhinitis (HP:0012384)1.61971385
170Growth hormone deficiency (HP:0000824)1.61730049
171Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61289201
172Abnormality of alanine metabolism (HP:0010916)1.61289201
173Hyperalaninemia (HP:0003348)1.61289201
174Cutaneous melanoma (HP:0012056)1.61215968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.67699121
2PRPF4B3.29190171
3MAP3K123.26010083
4FRK3.09733385
5WNK32.97275270
6TRIM282.70763401
7TNIK2.69756427
8STK392.56939313
9BMPR22.45545238
10MAP4K22.45370486
11BCR2.34220241
12MAP2K72.23875611
13MST42.22616641
14BMPR1B2.20769719
15OXSR12.15345964
16NUAK12.09966779
17STK162.08143054
18TXK2.06586416
19CDK191.98765778
20ACVR1B1.97653226
21MARK11.95215220
22MAPKAPK51.93123219
23PBK1.91428937
24TAOK31.91226071
25MUSK1.88038492
26ARAF1.79726874
27GRK71.65955779
28NLK1.63788111
29BRD41.60654937
30KSR11.56563601
31ADRBK21.56307287
32IRAK41.38292409
33TEC1.32477106
34MYLK1.28245265
35STK31.28164018
36CSNK1G31.27763185
37PLK41.26535585
38WNK41.23004680
39PRKD31.18547562
40MAPK131.16275935
41MAP3K141.15348582
42MAP3K91.13818150
43KSR21.13364946
44TTK1.12622587
45IRAK11.12189218
46LIMK11.09906332
47MAPK151.09597653
48PLK21.09344942
49VRK11.09286106
50MKNK21.09094634
51PLK31.04493741
52EPHA41.03746817
53SIK31.02764753
54CAMKK21.02211434
55EIF2AK20.99564182
56CSNK1G10.98640378
57CSNK1A1L0.98177713
58PAK30.98027743
59PIM20.93872607
60EPHA30.89059066
61YES10.88895717
62NEK60.88887971
63TGFBR10.87246120
64CDK90.85479199
65BRAF0.82902818
66DYRK20.82699138
67MET0.82543562
68SGK2230.82436495
69SGK4940.82436495
70MOS0.82372021
71MINK10.82154590
72AKT30.81921200
73FES0.81600133
74GRK50.80651788
75CAMK2B0.79080466
76CSNK1G20.78779804
77STK38L0.77700338
78WNK10.76354421
79CDK80.75164600
80PNCK0.74302338
81MELK0.74286536
82CCNB10.74229678
83UHMK10.72790143
84FGR0.72242753
85PRKCE0.72132720
86PLK10.72106060
87CAMK2A0.71728370
88MKNK10.71444713
89STK240.70823411
90BUB10.70578864
91KIT0.69791806
92CDK30.69720467
93CDC70.67998605
94NEK10.67795092
95SRPK10.67074581
96NEK90.66951704
97CAMK2D0.66275407
98PRKCG0.65657806
99EPHB10.64981568
100ERBB40.64118781
101TRPM70.63696116
102ITK0.62215058
103PHKG10.61882349
104PAK60.61787757
105EIF2AK10.61692063
106EIF2AK30.61526367
107LATS10.61238059
108TSSK60.60579527
109JAK30.60302806
110BRSK10.59008107
111PRKCQ0.56053335
112CLK10.55857320
113MAP3K130.55023535
114IRAK20.54174166
115CAMK2G0.53760281
116MAP3K40.52933721
117LCK0.52445857
118PKN10.49638073
119ADRBK10.49298091
120IKBKE0.49080608
121ATM0.48612214
122IRAK30.48173914
123GRK10.47834605
124KDR0.47391478
125ROCK20.46611424
126WEE10.45252572
127CSNK1D0.44239791
128NTRK20.43781683
129HIPK20.43677815
130PRKCI0.42169989
131SGK20.42126328
132ATR0.41753012
133PTK2B0.40695416
134NTRK10.40585603
135ZAK0.40429998
136BTK0.39970035
137SYK0.39378438
138CSNK1E0.37866259
139OBSCN0.37689756
140RAF10.37356689
141AURKA0.36788896
142MAP3K20.36755564
143NTRK30.36723859
144LYN0.36506445
145TNK20.36182622
146CAMK1G0.35332091
147CHEK10.35256667
148ERBB30.35047624
149IKBKB0.34315790
150CDK50.34252240
151PINK10.34057188
152BRSK20.32138150
153PHKG20.31512488

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.18887173
2Oxidative phosphorylation_Homo sapiens_hsa001902.87306175
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.62964923
4Proteasome_Homo sapiens_hsa030502.39076067
5Parkinsons disease_Homo sapiens_hsa050122.27209629
6Collecting duct acid secretion_Homo sapiens_hsa049662.15548588
7Mismatch repair_Homo sapiens_hsa034302.09151581
8Oocyte meiosis_Homo sapiens_hsa041142.04859710
9Rheumatoid arthritis_Homo sapiens_hsa053231.85243580
10Alzheimers disease_Homo sapiens_hsa050101.85215258
11Cell cycle_Homo sapiens_hsa041101.82775589
12Vibrio cholerae infection_Homo sapiens_hsa051101.80939869
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76856528
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75909988
15Basal transcription factors_Homo sapiens_hsa030221.72315255
16Allograft rejection_Homo sapiens_hsa053301.71063650
17Ether lipid metabolism_Homo sapiens_hsa005651.69193036
18Primary immunodeficiency_Homo sapiens_hsa053401.68388781
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67303259
20Vitamin B6 metabolism_Homo sapiens_hsa007501.65764576
21Non-homologous end-joining_Homo sapiens_hsa034501.65329985
22Fatty acid elongation_Homo sapiens_hsa000621.63860987
23Huntingtons disease_Homo sapiens_hsa050161.61279222
24Butanoate metabolism_Homo sapiens_hsa006501.52167871
25Autoimmune thyroid disease_Homo sapiens_hsa053201.51665289
26Sphingolipid metabolism_Homo sapiens_hsa006001.47492789
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44179305
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41502847
29Serotonergic synapse_Homo sapiens_hsa047261.40132053
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38241912
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36919811
32RNA transport_Homo sapiens_hsa030131.36038294
33Propanoate metabolism_Homo sapiens_hsa006401.35566771
34RNA polymerase_Homo sapiens_hsa030201.29872849
35Steroid biosynthesis_Homo sapiens_hsa001001.29726436
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28706332
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28325328
38Caffeine metabolism_Homo sapiens_hsa002321.27875805
39Type I diabetes mellitus_Homo sapiens_hsa049401.26910494
40p53 signaling pathway_Homo sapiens_hsa041151.25839591
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.25105442
42Synaptic vesicle cycle_Homo sapiens_hsa047211.25018940
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24768962
44Olfactory transduction_Homo sapiens_hsa047401.24067420
45Gap junction_Homo sapiens_hsa045401.21687352
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17065185
47Phototransduction_Homo sapiens_hsa047441.16591482
48Phagosome_Homo sapiens_hsa041451.14439934
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13434728
50Dorso-ventral axis formation_Homo sapiens_hsa043201.09943196
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09821581
52Graft-versus-host disease_Homo sapiens_hsa053321.07736156
53Regulation of autophagy_Homo sapiens_hsa041401.05064289
54Hematopoietic cell lineage_Homo sapiens_hsa046401.01990614
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01356507
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00327525
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00003482
58mRNA surveillance pathway_Homo sapiens_hsa030150.99889857
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98083949
60Morphine addiction_Homo sapiens_hsa050320.94792721
61DNA replication_Homo sapiens_hsa030300.94159944
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89893909
63Taste transduction_Homo sapiens_hsa047420.89785286
64RNA degradation_Homo sapiens_hsa030180.89582512
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88570460
66Selenocompound metabolism_Homo sapiens_hsa004500.87896775
67Nicotine addiction_Homo sapiens_hsa050330.85815114
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.85116303
69Renin secretion_Homo sapiens_hsa049240.84830139
70Malaria_Homo sapiens_hsa051440.84602877
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82539563
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82262245
73Asthma_Homo sapiens_hsa053100.81424099
74Shigellosis_Homo sapiens_hsa051310.78907442
75Homologous recombination_Homo sapiens_hsa034400.78156645
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77824789
77TGF-beta signaling pathway_Homo sapiens_hsa043500.77178405
78Measles_Homo sapiens_hsa051620.75279353
79Ovarian steroidogenesis_Homo sapiens_hsa049130.74873697
80GABAergic synapse_Homo sapiens_hsa047270.73565204
81Glutamatergic synapse_Homo sapiens_hsa047240.73161702
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73000239
83Other glycan degradation_Homo sapiens_hsa005110.72779566
84Base excision repair_Homo sapiens_hsa034100.72576963
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71197195
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70946920
87Oxytocin signaling pathway_Homo sapiens_hsa049210.68714939
88Arachidonic acid metabolism_Homo sapiens_hsa005900.68289284
89Nucleotide excision repair_Homo sapiens_hsa034200.68237483
90Circadian entrainment_Homo sapiens_hsa047130.67857719
91Long-term potentiation_Homo sapiens_hsa047200.67063313
92African trypanosomiasis_Homo sapiens_hsa051430.66576118
93Dopaminergic synapse_Homo sapiens_hsa047280.65588293
94Purine metabolism_Homo sapiens_hsa002300.64739734
95Sulfur metabolism_Homo sapiens_hsa009200.64376202
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63688918
97Alcoholism_Homo sapiens_hsa050340.62597376
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61745298
99Long-term depression_Homo sapiens_hsa047300.60563643
100T cell receptor signaling pathway_Homo sapiens_hsa046600.59645509
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59202887
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57287374
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.56113468
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.55697380
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55013205
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54362983
107Salmonella infection_Homo sapiens_hsa051320.54307724
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.53799444
109Cholinergic synapse_Homo sapiens_hsa047250.53457575
110cAMP signaling pathway_Homo sapiens_hsa040240.52457196
111Ras signaling pathway_Homo sapiens_hsa040140.52042019
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51290984
113Linoleic acid metabolism_Homo sapiens_hsa005910.49688377
114Amphetamine addiction_Homo sapiens_hsa050310.49313441
115Axon guidance_Homo sapiens_hsa043600.48995285
116Calcium signaling pathway_Homo sapiens_hsa040200.48723091
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48560732
118Fanconi anemia pathway_Homo sapiens_hsa034600.45751993
119Hippo signaling pathway_Homo sapiens_hsa043900.45568665
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.45010189
121FoxO signaling pathway_Homo sapiens_hsa040680.44650060
122Chemokine signaling pathway_Homo sapiens_hsa040620.44476408
123Circadian rhythm_Homo sapiens_hsa047100.44389788
124Pertussis_Homo sapiens_hsa051330.43828141
125Ribosome_Homo sapiens_hsa030100.43013955
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42897226
127Antigen processing and presentation_Homo sapiens_hsa046120.42704527
128Spliceosome_Homo sapiens_hsa030400.42691830
129Cocaine addiction_Homo sapiens_hsa050300.42644020
130Lysine degradation_Homo sapiens_hsa003100.42177053
131Insulin secretion_Homo sapiens_hsa049110.42097494
132Epstein-Barr virus infection_Homo sapiens_hsa051690.41762845
133Peroxisome_Homo sapiens_hsa041460.41321668
134N-Glycan biosynthesis_Homo sapiens_hsa005100.41125027
135Lysosome_Homo sapiens_hsa041420.40929592
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40346757
137Tuberculosis_Homo sapiens_hsa051520.39457659
138ABC transporters_Homo sapiens_hsa020100.38997275
139Salivary secretion_Homo sapiens_hsa049700.37966775
140mTOR signaling pathway_Homo sapiens_hsa041500.37944439
141Nitrogen metabolism_Homo sapiens_hsa009100.37725863
142Inositol phosphate metabolism_Homo sapiens_hsa005620.36573101
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36253017
144Cardiac muscle contraction_Homo sapiens_hsa042600.36212035
145Folate biosynthesis_Homo sapiens_hsa007900.35321525
146Pyrimidine metabolism_Homo sapiens_hsa002400.35022731
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33733737
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.33243823

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