GNPTAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.64435846
2axon ensheathment in central nervous system (GO:0032291)5.64435846
3protein localization to endosome (GO:0036010)5.23670556
4response to redox state (GO:0051775)5.11881013
5nerve growth factor signaling pathway (GO:0038180)4.98589348
6neuronal action potential propagation (GO:0019227)4.82330358
7positive regulation of gamma-delta T cell activation (GO:0046645)4.33558030
8synaptic vesicle maturation (GO:0016188)4.18109693
9layer formation in cerebral cortex (GO:0021819)4.08639643
10regulation of B cell receptor signaling pathway (GO:0050855)4.07515470
11regulation of synaptic vesicle exocytosis (GO:2000300)4.03228157
12ensheathment of neurons (GO:0007272)3.96400709
13axon ensheathment (GO:0008366)3.96400709
14response to nerve growth factor (GO:1990089)3.93908315
15cellular response to nerve growth factor stimulus (GO:1990090)3.93908315
16mating behavior (GO:0007617)3.92609404
17myelination (GO:0042552)3.92377288
18apical protein localization (GO:0045176)3.91633534
19detection of molecule of bacterial origin (GO:0032490)3.87316164
20adult walking behavior (GO:0007628)3.84787784
21positive regulation by symbiont of host defense response (GO:0052509)3.83121861
22modulation by symbiont of host defense response (GO:0052031)3.83121861
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83121861
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83121861
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.83121861
26modulation by symbiont of host immune response (GO:0052553)3.83121861
27neuron remodeling (GO:0016322)3.80910005
28negative regulation of neurotransmitter secretion (GO:0046929)3.78334628
29membrane tubulation (GO:0097320)3.61038525
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52336972
31fatty acid elongation (GO:0030497)3.51139704
32locomotory exploration behavior (GO:0035641)3.47954967
33regulation of axon regeneration (GO:0048679)3.41766307
34regulation of neuron projection regeneration (GO:0070570)3.41766307
35macrophage activation involved in immune response (GO:0002281)3.41388613
36long-chain fatty acid biosynthetic process (GO:0042759)3.39014843
37protein kinase C signaling (GO:0070528)3.37683973
38response to hydroperoxide (GO:0033194)3.36966019
39regulation of gamma-delta T cell activation (GO:0046643)3.35237546
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.31521761
41B cell receptor signaling pathway (GO:0050853)3.30107359
42cellular response to ethanol (GO:0071361)3.29328896
43negative regulation of calcium ion transport into cytosol (GO:0010523)3.29095861
44negative regulation of neurotransmitter transport (GO:0051589)3.28975374
45regulation of gamma-delta T cell differentiation (GO:0045586)3.28231130
46leukotriene biosynthetic process (GO:0019370)3.27424199
47L-amino acid import (GO:0043092)3.22126810
48microglial cell activation (GO:0001774)3.21860979
49myelin maintenance (GO:0043217)3.21055946
50magnesium ion transport (GO:0015693)3.19879387
51cellular copper ion homeostasis (GO:0006878)3.16542483
52asymmetric protein localization (GO:0008105)3.16413458
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15590809
54cellular response to interleukin-15 (GO:0071350)3.15100618
55clathrin coat assembly (GO:0048268)3.14892485
56response to vitamin E (GO:0033197)3.11545933
57negative regulation of interleukin-12 production (GO:0032695)3.10876643
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08073644
59hepatocyte apoptotic process (GO:0097284)3.07146062
60regulation of receptor binding (GO:1900120)3.06762584
61regulation of synaptic vesicle transport (GO:1902803)3.06700240
62phospholipid translocation (GO:0045332)3.06033125
63lipid translocation (GO:0034204)3.06033125
64establishment of mitochondrion localization (GO:0051654)3.01842642
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.00973784
66T cell migration (GO:0072678)3.00042963
67cortical actin cytoskeleton organization (GO:0030866)2.99533854
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98849780
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96768516
70negative regulation of erythrocyte differentiation (GO:0045647)2.95873844
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.95211367
72cytoplasmic mRNA processing body assembly (GO:0033962)2.95110417
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.94128017
74vesicle targeting (GO:0006903)2.91637882
75response to interleukin-15 (GO:0070672)2.89986977
76positive regulation of B cell differentiation (GO:0045579)2.89457994
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89208196
78mannose metabolic process (GO:0006013)2.88476932
79glutamate secretion (GO:0014047)2.87773574
80interkinetic nuclear migration (GO:0022027)2.87579145
81neuron cell-cell adhesion (GO:0007158)2.87414226
82membrane assembly (GO:0071709)2.87154601
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86757650
84response to host immune response (GO:0052572)2.86757650
85dendrite morphogenesis (GO:0048813)2.86179708
86membrane raft organization (GO:0031579)2.85748511
87histone H3-K36 demethylation (GO:0070544)2.84141792
88synaptic vesicle exocytosis (GO:0016079)2.83715079
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83443858
90regulation of ARF GTPase activity (GO:0032312)2.81935103
91positive regulation of macroautophagy (GO:0016239)2.80576830
92protein localization to synapse (GO:0035418)2.80160255
93astrocyte development (GO:0014002)2.79714913
94positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.78677430
95import into cell (GO:0098657)2.77010552
96negative regulation of B cell proliferation (GO:0030889)2.76815803
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75726830
98glycosylceramide metabolic process (GO:0006677)2.73222880
99endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73033598
100response to lipoprotein particle (GO:0055094)2.72923020
101response to peptidoglycan (GO:0032494)2.72300639
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71643407
103T-helper cell differentiation (GO:0042093)2.71506574
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71506574
105regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70027329
106regulation of amyloid precursor protein catabolic process (GO:1902991)2.69607910
107response to host (GO:0075136)2.69408103
108response to host defenses (GO:0052200)2.69408103
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69408103
110creatine metabolic process (GO:0006600)2.68296838
111cortical cytoskeleton organization (GO:0030865)2.67373238
112organelle transport along microtubule (GO:0072384)2.66718748
113negative regulation of cell killing (GO:0031342)2.64593789
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64593789
115positive T cell selection (GO:0043368)2.63564468
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.63001204
117semaphorin-plexin signaling pathway (GO:0071526)2.61965456
118transepithelial transport (GO:0070633)2.61825230
119negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.61591056
120gamma-aminobutyric acid transport (GO:0015812)2.61160901
121negative regulation of axonogenesis (GO:0050771)2.61103960
122macrophage activation (GO:0042116)2.60950175
123regulation of necroptotic process (GO:0060544)2.60863836
124detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.60597891
125detection of temperature stimulus involved in sensory perception (GO:0050961)2.60597891
126negative regulation of heart rate (GO:0010459)2.59635093
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59045819
128CDP-diacylglycerol biosynthetic process (GO:0016024)2.58857164
129cellular extravasation (GO:0045123)2.58770122
130neuromuscular process controlling balance (GO:0050885)2.56996330
131vesicle transport along microtubule (GO:0047496)2.56237450
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.55209994
133glutamate receptor signaling pathway (GO:0007215)2.53576337
134dendritic spine morphogenesis (GO:0060997)2.53409154
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53362802
136axon development (GO:0061564)2.52971521
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52899043
138regulation of B cell differentiation (GO:0045577)2.51960668
139positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51529449
140mature B cell differentiation (GO:0002335)2.50881008
141leukotriene metabolic process (GO:0006691)2.48394294
142protein palmitoylation (GO:0018345)2.47851627
143positive thymic T cell selection (GO:0045059)2.45914773
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.45260971
145copper ion homeostasis (GO:0055070)2.45204410
146positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.44801963
147suckling behavior (GO:0001967)2.44479490
148cellular response to thyroid hormone stimulus (GO:0097067)2.43964344
149neuron recognition (GO:0008038)2.43336444
150regulation of T cell tolerance induction (GO:0002664)2.42992997
151Rap protein signal transduction (GO:0032486)2.42586020
152replicative senescence (GO:0090399)2.42320758
153regulation of interferon-beta biosynthetic process (GO:0045357)2.41768890
154myeloid cell activation involved in immune response (GO:0002275)2.41199407
155Golgi to endosome transport (GO:0006895)2.40442282
156detection of external biotic stimulus (GO:0098581)2.39691485
157transmission of nerve impulse (GO:0019226)2.39402698
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.38690959
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38390758
160L-serine transport (GO:0015825)2.37762084
161stress fiber assembly (GO:0043149)2.37508259
162CDP-diacylglycerol metabolic process (GO:0046341)2.37470924
163B cell homeostasis (GO:0001782)2.37380537
164positive regulation of regulated secretory pathway (GO:1903307)2.36708256
165regulation of tolerance induction (GO:0002643)2.35747269
166alpha-beta T cell differentiation involved in immune response (GO:0002293)2.35732786
167alpha-beta T cell activation involved in immune response (GO:0002287)2.35732786
168T cell differentiation involved in immune response (GO:0002292)2.35732786
169negative T cell selection (GO:0043383)2.35292270
170positive regulation of interferon-alpha production (GO:0032727)2.34978563
171cerebellar Purkinje cell differentiation (GO:0021702)2.34903283
172negative regulation of interleukin-17 production (GO:0032700)2.33445908
173cytidine metabolic process (GO:0046087)2.32973461
174cytidine catabolic process (GO:0006216)2.32973461
175cytidine deamination (GO:0009972)2.32973461
176pyrimidine ribonucleoside catabolic process (GO:0046133)2.32911913
177interferon-gamma production (GO:0032609)2.31450772
178iron ion import (GO:0097286)2.30852499
179positive regulation of tolerance induction (GO:0002645)2.29580725
180neutrophil activation involved in immune response (GO:0002283)2.27619551
181antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27162530
182CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.26986386
183antigen processing and presentation of endogenous antigen (GO:0019883)2.24729844
184regulation of interferon-alpha production (GO:0032647)2.24481292
185definitive hemopoiesis (GO:0060216)2.24408034
186protein targeting to vacuole (GO:0006623)2.24227737
187protein targeting to lysosome (GO:0006622)2.24227737
188establishment of protein localization to vacuole (GO:0072666)2.24227737
189T cell costimulation (GO:0031295)2.24161136
190peptide catabolic process (GO:0043171)2.24016400
191regulation of B cell proliferation (GO:0030888)2.23312845
192regulation of establishment of cell polarity (GO:2000114)2.23129698
193response to muramyl dipeptide (GO:0032495)2.22629348
194negative thymic T cell selection (GO:0045060)2.21160085
195positive regulation of leukocyte degranulation (GO:0043302)2.20980093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.38617373
2TAF15_26573619_Chip-Seq_HEK293_Human3.30892712
3GATA1_22025678_ChIP-Seq_K562_Human2.86999074
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.73063866
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.66853637
6NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.51260763
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39380550
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16613506
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.13024569
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07397452
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02947786
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02028616
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01846923
14SCL_19346495_ChIP-Seq_HPC-7_Human1.99370669
15DROSHA_22980978_ChIP-Seq_HELA_Human1.96746743
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95616370
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94977947
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93909501
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92438672
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87542054
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87110865
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86254963
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.82400826
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81970571
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80898933
26MYB_26560356_Chip-Seq_TH2_Human1.78157351
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77740319
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77740319
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75599989
30* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74246064
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73693809
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70543289
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.64410726
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.63411161
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59561762
36EZH2_22144423_ChIP-Seq_EOC_Human1.58751897
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57747149
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57537602
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57244430
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54788816
41AR_21572438_ChIP-Seq_LNCaP_Human1.54582103
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53439233
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52646496
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50810325
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49499320
46AHR_22903824_ChIP-Seq_MCF-7_Human1.48681204
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48599471
48KDM2B_26808549_Chip-Seq_K562_Human1.47169214
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47153779
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47011303
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44918648
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43752421
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42637226
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.39795166
55MYB_26560356_Chip-Seq_TH1_Human1.39117523
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38967189
57GATA3_27048872_Chip-Seq_THYMUS_Human1.38692178
58* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38027416
59VDR_24763502_ChIP-Seq_THP-1_Human1.36957267
60KDM2B_26808549_Chip-Seq_DND41_Human1.36431372
61SPI1_23127762_ChIP-Seq_K562_Human1.35607587
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.34201257
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33946060
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33945541
65TP53_16413492_ChIP-PET_HCT116_Human1.32004039
66GATA1_19941826_ChIP-Seq_K562_Human1.29276329
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29045264
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28894516
69* PU_27001747_Chip-Seq_BMDM_Mouse1.26223871
70GBX2_23144817_ChIP-Seq_PC3_Human1.25946410
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.25557147
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.24997756
73* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23664171
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22630489
75RXR_22108803_ChIP-Seq_LS180_Human1.21793851
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20630974
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20205207
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18795604
79REST_21632747_ChIP-Seq_MESCs_Mouse1.17876947
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16460110
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.15742991
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15590945
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15426527
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15426527
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.14290581
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.13361975
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.13181513
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13079321
89GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12762524
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.12693136
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12668528
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12295892
93KLF5_25053715_ChIP-Seq_YYC3_Human1.10036814
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09776782
95GATA2_19941826_ChIP-Seq_K562_Human1.09406808
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08588025
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08505305
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08225904
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.07987882
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.07832322
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07793606
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07732432
103SMAD4_21799915_ChIP-Seq_A2780_Human1.07632214
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.05369426
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04815045
106* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04652606
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03639675
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03015143
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.02193709
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.02180533
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01966646
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01514271
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01121741
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00646675
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00622995
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.00558181
117* STAT3_23295773_ChIP-Seq_U87_Human1.00420623
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00105388
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99340315
120TCF4_23295773_ChIP-Seq_U87_Human0.98926965
121ER_23166858_ChIP-Seq_MCF-7_Human0.97983461
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.97941218
123VDR_24787735_ChIP-Seq_THP-1_Human0.97425243
124MAF_26560356_Chip-Seq_TH1_Human0.96818698
125CJUN_26792858_Chip-Seq_BT549_Human0.96020429
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.95709849
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.95623084
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95549462
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95091432
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94778015
131TP63_23658742_ChIP-Seq_EP156T_Human0.94283818
132KDM2B_26808549_Chip-Seq_REH_Human0.94173493
133EGR1_19374776_ChIP-ChIP_THP-1_Human0.93265927
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92667339
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91613802
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90895794
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90842680
138VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89859441
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88950750
140RUNX_20019798_ChIP-Seq_JUKART_Human0.88792467
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88642653
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88391014
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.88373335
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87953229
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87924514
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85895618
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84207150
148RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83831791
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83061539
150SPI1_23547873_ChIP-Seq_NB4_Human0.82003872
151GATA3_26560356_Chip-Seq_TH2_Human0.77586907
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75791665
153* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75574461
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.75315030
155SMRT_27268052_Chip-Seq_Bcells_Human0.75305475
156VDR_21846776_ChIP-Seq_THP-1_Human0.74949512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003329_amyloid_beta_deposits4.72365869
2MP0004270_analgesia4.36945615
3MP0004859_abnormal_synaptic_plasticity4.09447953
4MP0000920_abnormal_myelination3.73422083
5MP0000604_amyloidosis3.29836106
6MP0003303_peritoneal_inflammation3.26728145
7MP0001835_abnormal_antigen_presentation3.05891875
8MP0008057_abnormal_DNA_replication2.88953281
9MP0003690_abnormal_glial_cell2.85683672
10MP0003172_abnormal_lysosome_physiology2.55190470
11MP0005671_abnormal_response_to2.51802143
12MP0003880_abnormal_central_pattern2.43346726
13MP0003635_abnormal_synaptic_transmissio2.36570182
14MP0002877_abnormal_melanocyte_morpholog2.32208242
15MP0003763_abnormal_thymus_physiology2.27708534
16MP0003724_increased_susceptibility_to2.26227993
17MP0009046_muscle_twitch2.25393728
18MP0001501_abnormal_sleep_pattern2.22154592
19MP0008260_abnormal_autophagy2.13735317
20MP0002064_seizures2.11198477
21MP0000778_abnormal_nervous_system2.06174672
22MP0000015_abnormal_ear_pigmentation2.02246115
23MP0003634_abnormal_glial_cell2.00145055
24MP0001968_abnormal_touch/_nociception1.99640299
25MP0004858_abnormal_nervous_system1.98708913
26MP0002272_abnormal_nervous_system1.95882178
27MP0002009_preneoplasia1.94736911
28MP0002166_altered_tumor_susceptibility1.91607362
29MP0003632_abnormal_nervous_system1.89890985
30MP0005058_abnormal_lysosome_morphology1.88508873
31MP0002734_abnormal_mechanical_nocicepti1.88315746
32MP0001299_abnormal_eye_distance/1.78394901
33MP0002148_abnormal_hypersensitivity_rea1.77214425
34MP0000371_diluted_coat_color1.77032336
35MP0004381_abnormal_hair_follicle1.75760764
36MP0004885_abnormal_endolymph1.74531697
37MP0003045_fibrosis1.72202019
38MP0005025_abnormal_response_to1.71482270
39MP0003828_pulmonary_edema1.71415353
40MP0009785_altered_susceptibility_to1.70434920
41MP0009745_abnormal_behavioral_response1.69333090
42MP0002998_abnormal_bone_remodeling1.67805963
43MP0001958_emphysema1.67552479
44MP0002063_abnormal_learning/memory/cond1.65502825
45MP0003436_decreased_susceptibility_to1.62575749
46MP0002398_abnormal_bone_marrow1.59636097
47MP0000716_abnormal_immune_system1.58952953
48MP0000569_abnormal_digit_pigmentation1.57557530
49MP0005310_abnormal_salivary_gland1.56042044
50MP0005409_darkened_coat_color1.55462430
51MP0002405_respiratory_system_inflammati1.54691306
52MP0000751_myopathy1.54501225
53MP0004130_abnormal_muscle_cell1.53255395
54MP0004808_abnormal_hematopoietic_stem1.52108056
55MP0010678_abnormal_skin_adnexa1.49033010
56MP0003300_gastrointestinal_ulcer1.48863576
57MP0010155_abnormal_intestine_physiology1.47491590
58MP0001486_abnormal_startle_reflex1.44642551
59MP0005464_abnormal_platelet_physiology1.43079788
60MP0000689_abnormal_spleen_morphology1.40751186
61MP0005623_abnormal_meninges_morphology1.40340422
62MP0002572_abnormal_emotion/affect_behav1.40108468
63MP0003279_aneurysm1.36793202
64MP0003631_nervous_system_phenotype1.36563668
65MP0000955_abnormal_spinal_cord1.36006813
66MP0002006_tumorigenesis1.34932743
67MP0001853_heart_inflammation1.34464513
68MP0008438_abnormal_cutaneous_collagen1.33022270
69MP0004142_abnormal_muscle_tone1.29875587
70MP0002733_abnormal_thermal_nociception1.29484543
71MP0002722_abnormal_immune_system1.28482118
72MP0000383_abnormal_hair_follicle1.28460609
73MP0002396_abnormal_hematopoietic_system1.26686836
74* MP0002229_neurodegeneration1.24403743
75MP0001970_abnormal_pain_threshold1.23651617
76MP0006054_spinal_hemorrhage1.22642878
77MP0001873_stomach_inflammation1.21064739
78MP0002067_abnormal_sensory_capabilities1.21055488
79MP0001533_abnormal_skeleton_physiology1.20987000
80MP0008569_lethality_at_weaning1.20784155
81MP0004264_abnormal_extraembryonic_tissu1.19593800
82MP0009780_abnormal_chondrocyte_physiolo1.18834147
83MP0002254_reproductive_system_inflammat1.18442326
84MP0000372_irregular_coat_pigmentation1.18405011
85MP0003633_abnormal_nervous_system1.16965963
86MP0004811_abnormal_neuron_physiology1.16363291
87MP0002429_abnormal_blood_cell1.16056767
88MP0004924_abnormal_behavior1.15256799
89MP0005386_behavior/neurological_phenoty1.15256799
90MP0000747_muscle_weakness1.15251631
91MP0001845_abnormal_inflammatory_respons1.13022705
92MP0002066_abnormal_motor_capabilities/c1.12180178
93MP0000703_abnormal_thymus_morphology1.10920501
94MP0009764_decreased_sensitivity_to1.10176087
95* MP0002882_abnormal_neuron_morphology1.09809205
96MP0001440_abnormal_grooming_behavior1.09760886
97MP0004185_abnormal_adipocyte_glucose1.09556589
98MP0003091_abnormal_cell_migration1.08791585
99MP0002909_abnormal_adrenal_gland1.08363378
100MP0003075_altered_response_to1.07882068
101MP0003950_abnormal_plasma_membrane1.07422560
102MP0009333_abnormal_splenocyte_physiolog1.07344887
103MP0002138_abnormal_hepatobiliary_system1.03831264
104MP0005423_abnormal_somatic_nervous1.03073628
105MP0005075_abnormal_melanosome_morpholog1.00570273
106MP0003866_abnormal_defecation1.00396190
107MP0005171_absent_coat_pigmentation0.97411299
108MP0010352_gastrointestinal_tract_polyps0.97386618
109MP0004883_abnormal_blood_vessel0.97142900
110MP0004947_skin_inflammation0.96513313
111MP0000858_altered_metastatic_potential0.95893727
112MP0003191_abnormal_cellular_cholesterol0.95496237
113MP0004510_myositis0.94588698
114MP0000685_abnormal_immune_system0.94223167
115MP0001851_eye_inflammation0.91607361
116MP0004484_altered_response_of0.90818158
117MP0005388_respiratory_system_phenotype0.90511716
118MP0002133_abnormal_respiratory_system0.90511716
119MP0002933_joint_inflammation0.89958488
120MP0005387_immune_system_phenotype0.89779210
121MP0001790_abnormal_immune_system0.89779210
122MP0002089_abnormal_postnatal_growth/wei0.89039969
123MP0003646_muscle_fatigue0.88204304
124MP0005164_abnormal_response_to0.87695520
125MP0003448_altered_tumor_morphology0.84304339
126MP0002075_abnormal_coat/hair_pigmentati0.83060153
127MP0006082_CNS_inflammation0.82671730
128MP0010307_abnormal_tumor_latency0.81410230
129MP0005257_abnormal_intraocular_pressure0.81138482
130MP0001905_abnormal_dopamine_level0.80621895
131MP0004742_abnormal_vestibular_system0.80061625
132MP0003221_abnormal_cardiomyocyte_apopto0.80022798
133MP0004134_abnormal_chest_morphology0.79942122
134MP0002184_abnormal_innervation0.79071503
135MP0002735_abnormal_chemical_nociception0.78557862
136MP0005275_abnormal_skin_tensile0.78275827
137* MP0003183_abnormal_peptide_metabolism0.77302490
138MP0002152_abnormal_brain_morphology0.76452106
139MP0005076_abnormal_cell_differentiation0.75819003
140MP0001177_atelectasis0.75205956
141MP0002332_abnormal_exercise_endurance0.73640115
142MP0005174_abnormal_tail_pigmentation0.73570155
143MP0005647_abnormal_sex_gland0.73206389
144MP0000465_gastrointestinal_hemorrhage0.72996868
145MP0004233_abnormal_muscle_weight0.72829602
146MP0009115_abnormal_fat_cell0.71904021
147MP0001485_abnormal_pinna_reflex0.71203783
148MP0001348_abnormal_lacrimal_gland0.70901235
149MP0000767_abnormal_smooth_muscle0.70855200
150MP0002419_abnormal_innate_immunity0.70270501
151MP0005397_hematopoietic_system_phenotyp0.69939180
152MP0001545_abnormal_hematopoietic_system0.69939180
153MP0008874_decreased_physiological_sensi0.66213657
154MP0001800_abnormal_humoral_immune0.64648487
155MP0003566_abnormal_cell_adhesion0.63387145
156MP0005000_abnormal_immune_tolerance0.61135919
157MP0002736_abnormal_nociception_after0.57940157
158MP0002971_abnormal_brown_adipose0.56614582
159MP0001943_abnormal_respiration0.55685735
160MP0002420_abnormal_adaptive_immunity0.53269734
161MP0002723_abnormal_immune_serum0.52865039
162MP0002452_abnormal_antigen_presenting0.51539578
163MP0001819_abnormal_immune_cell0.51092679
164MP0003656_abnormal_erythrocyte_physiolo0.50223314

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)7.30527551
2Cerebral inclusion bodies (HP:0100314)6.26591188
3Sensory axonal neuropathy (HP:0003390)5.29056648
4Papilledema (HP:0001085)5.22980703
5Supranuclear gaze palsy (HP:0000605)5.05778606
6T lymphocytopenia (HP:0005403)4.47611646
7Abnormality of T cell number (HP:0011839)4.04535623
8Spontaneous hematomas (HP:0007420)3.74158262
9Ankle clonus (HP:0011448)3.39213244
10Insidious onset (HP:0003587)3.32680000
11Termporal pattern (HP:0011008)3.32680000
12Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.31231918
13Neuronal loss in central nervous system (HP:0002529)3.28297798
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.23948075
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.23948075
16Dyschromatopsia (HP:0007641)3.20873121
17Submucous cleft hard palate (HP:0000176)3.19660887
18Myokymia (HP:0002411)3.16900053
19Peripheral hypomyelination (HP:0007182)3.13570372
20Abnormality of the corticospinal tract (HP:0002492)3.08366670
21Cerebral hemorrhage (HP:0001342)3.02318568
22Slow saccadic eye movements (HP:0000514)3.01215642
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.92296063
24Recurrent bacterial skin infections (HP:0005406)2.91054188
25Chronic mucocutaneous candidiasis (HP:0002728)2.90972166
26Recurrent cutaneous fungal infections (HP:0011370)2.90972166
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.89073917
28Disinhibition (HP:0000734)2.88833539
29Eczematoid dermatitis (HP:0000976)2.83890345
30Alacrima (HP:0000522)2.81092288
31Chin dimple (HP:0010751)2.79932190
32Recurrent fungal infections (HP:0002841)2.75961202
33Action tremor (HP:0002345)2.75011808
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74315123
35Dysmetria (HP:0001310)2.73932877
36Arterial tortuosity (HP:0005116)2.67385471
37Amyloidosis (HP:0011034)2.63021446
38Recurrent viral infections (HP:0004429)2.62851206
39Urinary bladder sphincter dysfunction (HP:0002839)2.61630129
40Spastic gait (HP:0002064)2.59996741
41Resting tremor (HP:0002322)2.59316463
42Mutism (HP:0002300)2.56583975
43Onion bulb formation (HP:0003383)2.52952107
44Chronic diarrhea (HP:0002028)2.48379772
45Recurrent abscess formation (HP:0002722)2.47469260
46Abnormality of binocular vision (HP:0011514)2.45738134
47Diplopia (HP:0000651)2.45738134
48Urinary urgency (HP:0000012)2.45219209
49Rectal prolapse (HP:0002035)2.42496901
50Chest pain (HP:0100749)2.40109789
51* Broad ribs (HP:0000885)2.39310654
52Inappropriate behavior (HP:0000719)2.38267412
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.37520151
54Rapidly progressive (HP:0003678)2.37467059
55Mediastinal lymphadenopathy (HP:0100721)2.35929592
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34967327
57Recurrent skin infections (HP:0001581)2.34247505
58Abnormality of T cells (HP:0002843)2.33889270
59Vascular tortuosity (HP:0004948)2.33425688
60Ureteral obstruction (HP:0006000)2.33210814
61Increased variability in muscle fiber diameter (HP:0003557)2.32817592
62Progressive cerebellar ataxia (HP:0002073)2.32204042
63Autoimmune hemolytic anemia (HP:0001890)2.31810063
64Abnormality of the fingertips (HP:0001211)2.31770374
65Choroideremia (HP:0001139)2.30191971
66Vasculitis (HP:0002633)2.26325790
67Pulmonary infiltrates (HP:0002113)2.25497268
68Distal arthrogryposis (HP:0005684)2.23589213
69Progressive inability to walk (HP:0002505)2.23123535
70Focal seizures (HP:0007359)2.22911621
71Spondylolisthesis (HP:0003302)2.22209307
72Thick nail (HP:0001805)2.20706430
73Absent frontal sinuses (HP:0002688)2.19753228
74Pheochromocytoma (HP:0002666)2.18771384
75Hemorrhage of the eye (HP:0011885)2.16766358
76Abnormality of macrophages (HP:0004311)2.16431920
77Autoimmune thrombocytopenia (HP:0001973)2.16041403
78Increased cerebral lipofuscin (HP:0011813)2.15951162
79* Abnormality of glycosphingolipid metabolism (HP:0004343)2.14889959
80* Abnormality of glycolipid metabolism (HP:0010969)2.14889959
81* Abnormality of liposaccharide metabolism (HP:0010968)2.14889959
82Apathy (HP:0000741)2.14531431
83Visual hallucinations (HP:0002367)2.14259765
84Obstructive sleep apnea (HP:0002870)2.13706015
85Postural instability (HP:0002172)2.13211322
86Macroorchidism (HP:0000053)2.11949850
87Anomalous pulmonary venous return (HP:0010772)2.10820542
88Dysmetric saccades (HP:0000641)2.10293235
89Abnormal auditory evoked potentials (HP:0006958)2.09768907
90Generalized hypopigmentation of hair (HP:0011358)2.09126564
91Postural tremor (HP:0002174)2.08817355
92Hemoptysis (HP:0002105)2.05875343
93Akinesia (HP:0002304)2.05549721
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05355570
95Intention tremor (HP:0002080)2.05097068
96Chronic otitis media (HP:0000389)2.04980776
97Decreased lacrimation (HP:0000633)2.04724255
98Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03309940
99Abnormality of the pulmonary veins (HP:0011718)2.02810657
100Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.02053123
101Truncal ataxia (HP:0002078)2.01936920
102Gingivitis (HP:0000230)2.00594827
103Abnormality of skeletal muscle fiber size (HP:0012084)1.99834365
104Lower limb muscle weakness (HP:0007340)1.99784687
105Protruding tongue (HP:0010808)1.99228928
106Neuroendocrine neoplasm (HP:0100634)1.98698585
107Hyporeflexia of lower limbs (HP:0002600)1.97906271
108Gastrointestinal infarctions (HP:0005244)1.97194762
109Mask-like facies (HP:0000298)1.96471694
110Meningitis (HP:0001287)1.96059857
111Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.94737725
112Conjunctival telangiectasia (HP:0000524)1.93573873
113* Thoracolumbar scoliosis (HP:0002944)1.93101456
114Colitis (HP:0002583)1.91907945
115Aqueductal stenosis (HP:0002410)1.91398692
116Arterial thrombosis (HP:0004420)1.91050558
117Focal motor seizures (HP:0011153)1.90654671
118Dysdiadochokinesis (HP:0002075)1.90451949
119Periodontitis (HP:0000704)1.89099955
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88737789
121Abnormality of saccadic eye movements (HP:0000570)1.88565384
122Axonal loss (HP:0003447)1.88422136
123* Dysostosis multiplex (HP:0000943)1.88296848
124Subacute progressive viral hepatitis (HP:0006572)1.88236427
125Hemiplegia (HP:0002301)1.87725236
126Restrictive lung disease (HP:0002091)1.87605707
127Genetic anticipation (HP:0003743)1.87413181
128Hyperthyroidism (HP:0000836)1.87321224
129Leukocytosis (HP:0001974)1.87075562
130Hypoplasia of the brainstem (HP:0002365)1.87029055
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87029055
132Insomnia (HP:0100785)1.86871405
133EMG: myopathic abnormalities (HP:0003458)1.86813584
134Overgrowth (HP:0001548)1.85728069
135Achilles tendon contracture (HP:0001771)1.84953095
136Clumsiness (HP:0002312)1.84836378
137Bronchomalacia (HP:0002780)1.84599166
138Curly hair (HP:0002212)1.84185966
139Spastic tetraparesis (HP:0001285)1.83337972
140Papillary thyroid carcinoma (HP:0002895)1.83285938
141Hematochezia (HP:0002573)1.82955713
142Diminished motivation (HP:0000745)1.82740460
143Narrow palate (HP:0000189)1.82153945
144Retrobulbar optic neuritis (HP:0100654)1.81679510
145Optic neuritis (HP:0100653)1.81679510
146Agammaglobulinemia (HP:0004432)1.81437506
147Distal sensory impairment (HP:0002936)1.81385291
148Delayed closure of the anterior fontanelle (HP:0001476)1.81165551
149Orchitis (HP:0100796)1.80172676
150Amaurosis fugax (HP:0100576)1.79308118
151IgA deficiency (HP:0002720)1.79274252
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78556041
153Testicular atrophy (HP:0000029)1.77656077
154Clonus (HP:0002169)1.77089611
155Osteolytic defects of the hand bones (HP:0009699)1.77070454
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.77070454
157Bowel incontinence (HP:0002607)1.76994329
158Myositis (HP:0100614)1.76721144
159Viral hepatitis (HP:0006562)1.75942981
160Acute myeloid leukemia (HP:0004808)1.75897018
161Gaze-evoked nystagmus (HP:0000640)1.75222684
162Ocular albinism (HP:0001107)1.74872551
163Abnormal large intestine physiology (HP:0012700)1.74523598
164External ophthalmoplegia (HP:0000544)1.73865336
165Pustule (HP:0200039)1.73756238
166Abnormality of ocular smooth pursuit (HP:0000617)1.73698984
167Pulmonary embolism (HP:0002204)1.73575582
168Cerebral aneurysm (HP:0004944)1.73280336
169Abnormality of the prostate (HP:0008775)1.72661115
170Increased CSF protein (HP:0002922)1.72346158
171Ureteral stenosis (HP:0000071)1.71957022
172Neoplasm of the peripheral nervous system (HP:0100007)1.71017526
173Slender build (HP:0001533)1.71014154
174Persistence of primary teeth (HP:0006335)1.69637405
175Widely spaced teeth (HP:0000687)1.67956479
176Thrombocytosis (HP:0001894)1.67480866
177Coarse hair (HP:0002208)1.66900802
178Osteomyelitis (HP:0002754)1.66409730
179Sparse lateral eyebrow (HP:0005338)1.66376988
180Fair hair (HP:0002286)1.65277974
181Impaired smooth pursuit (HP:0007772)1.64476072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.00824386
2STK393.21655753
3NME23.20523073
4PRPF4B2.99548130
5MAP4K12.84467848
6TXK2.80813104
7MAP3K92.56830817
8ICK2.49048139
9OXSR12.44686103
10EPHB12.41283502
11CAMK2D2.38304242
12RET2.21818442
13TGFBR22.17736188
14MAP3K142.14849622
15MARK12.13799331
16MAP2K32.07193206
17CDK121.92279556
18CAMKK21.90736804
19PNCK1.85200536
20LATS21.80651594
21PAK61.72922294
22JAK11.68785799
23GRK71.64070498
24SGK21.63426267
25FES1.60464046
26SYK1.57840686
27CDK191.57104215
28AKT31.56148255
29IRAK41.55890807
30DAPK21.52154861
31TRIB31.50862043
32NTRK31.50246087
33TEC1.49765183
34SIK21.45879579
35MATK1.43055845
36DAPK11.41284433
37FGFR31.40095802
38CAMK1G1.38436549
39CSK1.35888996
40FRK1.32956739
41IKBKE1.32375596
42MAP3K131.32312290
43PRKCQ1.31711915
44MAPKAPK51.30333776
45TYK21.28389261
46BMPR21.28024492
47ROCK21.25691285
48ACVR1B1.25477348
49CDK51.23437614
50SGK31.21771995
51IRAK11.21429727
52ALK1.19222339
53CSNK1A1L1.18487852
54JAK31.15787710
55TYRO31.15730539
56EPHA31.13896342
57ZAP701.13887285
58FGFR21.12978958
59CSNK1G21.12556181
60MAPKAPK31.11783455
61HCK1.11502697
62CSNK1G31.11494531
63NEK91.11101223
64KSR21.10688701
65CAMK41.06720219
66YES11.06405773
67PKN11.04506748
68PDPK11.01073001
69UHMK11.00961592
70TNIK0.98485787
71FGR0.96988690
72TRPM70.96612745
73MINK10.95499576
74LRRK20.95076933
75WNK10.94998300
76PRKCH0.92980208
77MET0.92639381
78JAK20.91624805
79CLK10.91542902
80FGFR40.91432909
81MAPK120.90556201
82NTRK20.90503114
83GRK60.90240134
84RIPK40.90072549
85ERN10.88695482
86CDK140.88669923
87PTK2B0.87011610
88TTN0.87010877
89FYN0.86454792
90CSNK1G10.85760099
91CSF1R0.85591031
92LCK0.84676415
93RIPK10.84091453
94IRAK20.82838702
95IKBKB0.82710612
96BTK0.81047176
97EPHB20.80321334
98LYN0.79560611
99PIK3CG0.78801737
100INSRR0.78210171
101SGK2230.77885516
102SGK4940.77885516
103ADRBK20.77113102
104CDK60.76720070
105LATS10.75089567
106PDK10.74133848
107TBK10.73197342
108EPHA40.72654193
109PHKG10.72062622
110PHKG20.72062622
111MAP3K60.71845752
112MAP3K30.70942354
113NLK0.70139730
114PKN20.69797089
115PLK20.69211246
116CAMKK10.69166456
117CHUK0.68836556
118MAP2K60.66816269
119EEF2K0.66057957
120MAP3K10.65320976
121CDK150.65113408
122SRC0.64198787
123LMTK20.63090193
124NEK60.62707608
125ABL10.61900936
126STK30.60503794
127CAMK1D0.59146062
128DMPK0.59075027
129BLK0.58170516
130CDK180.55965094
131PAK30.55911454
132PDGFRB0.55553265
133MAP2K40.55295238
134PIM10.54662603
135SGK10.54447875
136ITK0.54360654
137HIPK20.54278722
138MARK30.53694263
139MAP3K20.53338955
140TAOK30.52839456
141PAK20.51223904
142PRKCG0.50520333
143CDK11A0.50359193
144BRD40.50017072
145PIK3CA0.49740088
146PDGFRA0.49542586
147STK100.49406524
148TESK20.48528505
149INSR0.48073390
150PRKD10.47947352
151STK380.47528293
152MELK0.47198514
153MARK20.46562081
154MAP3K70.46033469
155SCYL20.45940081
156GRK50.45673378
157STK110.44975736
158MOS0.44841682
159CSNK1D0.44460107
160WNK40.43736908
161BCR0.42722876
162MAPK70.42571886
163ARAF0.42168539
164KIT0.41355454
165DAPK30.41163502
166BMX0.40810839
167LIMK10.39990410
168PRKCZ0.39061155

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53205669
2Synaptic vesicle cycle_Homo sapiens_hsa047211.97710987
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90744185
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83596713
5Graft-versus-host disease_Homo sapiens_hsa053321.80964552
6Leishmaniasis_Homo sapiens_hsa051401.79169241
7Steroid biosynthesis_Homo sapiens_hsa001001.73273986
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69538644
9Glutamatergic synapse_Homo sapiens_hsa047241.68573889
10Cholinergic synapse_Homo sapiens_hsa047251.62338528
11Dorso-ventral axis formation_Homo sapiens_hsa043201.59795437
12Long-term potentiation_Homo sapiens_hsa047201.58087979
13Phospholipase D signaling pathway_Homo sapiens_hsa040721.54333869
14Ether lipid metabolism_Homo sapiens_hsa005651.50806811
15Taste transduction_Homo sapiens_hsa047421.50174237
16Allograft rejection_Homo sapiens_hsa053301.49321712
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.48024250
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46382583
19Autoimmune thyroid disease_Homo sapiens_hsa053201.43781751
20B cell receptor signaling pathway_Homo sapiens_hsa046621.43589158
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43412485
22Axon guidance_Homo sapiens_hsa043601.42960897
23Long-term depression_Homo sapiens_hsa047301.41865858
24Staphylococcus aureus infection_Homo sapiens_hsa051501.40823240
25Serotonergic synapse_Homo sapiens_hsa047261.40436750
26Gastric acid secretion_Homo sapiens_hsa049711.39469044
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37760745
28Renal cell carcinoma_Homo sapiens_hsa052111.36695190
29Antigen processing and presentation_Homo sapiens_hsa046121.35445232
30GABAergic synapse_Homo sapiens_hsa047271.34044035
31Morphine addiction_Homo sapiens_hsa050321.32632437
32Primary immunodeficiency_Homo sapiens_hsa053401.32404749
33Acute myeloid leukemia_Homo sapiens_hsa052211.28576448
34Salivary secretion_Homo sapiens_hsa049701.28411000
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27357292
36Platelet activation_Homo sapiens_hsa046111.27104858
37TNF signaling pathway_Homo sapiens_hsa046681.24890576
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.24074847
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.23315299
40Toxoplasmosis_Homo sapiens_hsa051451.22703095
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22553825
42Olfactory transduction_Homo sapiens_hsa047401.22501570
43Oxytocin signaling pathway_Homo sapiens_hsa049211.22144011
44Measles_Homo sapiens_hsa051621.21515378
45Non-small cell lung cancer_Homo sapiens_hsa052231.20481077
46Chronic myeloid leukemia_Homo sapiens_hsa052201.18957839
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18728246
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18542307
49Nitrogen metabolism_Homo sapiens_hsa009101.18197494
50Circadian entrainment_Homo sapiens_hsa047131.17380440
51Endocytosis_Homo sapiens_hsa041441.17088333
52Asthma_Homo sapiens_hsa053101.16857418
53Dopaminergic synapse_Homo sapiens_hsa047281.16202979
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15543204
55Sphingolipid signaling pathway_Homo sapiens_hsa040711.15067077
56Renin secretion_Homo sapiens_hsa049241.13620642
57Hematopoietic cell lineage_Homo sapiens_hsa046401.13440684
58Prolactin signaling pathway_Homo sapiens_hsa049171.13321162
59Influenza A_Homo sapiens_hsa051641.12000379
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10285006
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09144181
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08967640
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.08734225
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08719717
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08087723
66Glioma_Homo sapiens_hsa052141.07329231
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07194922
68* Lysosome_Homo sapiens_hsa041421.06556203
69Leukocyte transendothelial migration_Homo sapiens_hsa046701.05877825
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00333357
71cAMP signaling pathway_Homo sapiens_hsa040240.99545530
72Nicotine addiction_Homo sapiens_hsa050330.98894432
73Cocaine addiction_Homo sapiens_hsa050300.97916687
74Pancreatic secretion_Homo sapiens_hsa049720.96910146
75Hepatitis B_Homo sapiens_hsa051610.96628576
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96372343
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93943685
78Estrogen signaling pathway_Homo sapiens_hsa049150.93774846
79Hepatitis C_Homo sapiens_hsa051600.93483933
80Type I diabetes mellitus_Homo sapiens_hsa049400.93191260
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93062469
82Prostate cancer_Homo sapiens_hsa052150.92577621
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.90017285
84T cell receptor signaling pathway_Homo sapiens_hsa046600.89515190
85Ras signaling pathway_Homo sapiens_hsa040140.89406581
86VEGF signaling pathway_Homo sapiens_hsa043700.88916741
87GnRH signaling pathway_Homo sapiens_hsa049120.88761667
88Chemokine signaling pathway_Homo sapiens_hsa040620.87625505
89Gap junction_Homo sapiens_hsa045400.86303562
90Collecting duct acid secretion_Homo sapiens_hsa049660.86075068
91Focal adhesion_Homo sapiens_hsa045100.85774820
92Rap1 signaling pathway_Homo sapiens_hsa040150.85637977
93Endometrial cancer_Homo sapiens_hsa052130.85432727
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85139201
95ErbB signaling pathway_Homo sapiens_hsa040120.84949340
96FoxO signaling pathway_Homo sapiens_hsa040680.83539075
97Type II diabetes mellitus_Homo sapiens_hsa049300.82596442
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82458453
99MAPK signaling pathway_Homo sapiens_hsa040100.82306751
100Inositol phosphate metabolism_Homo sapiens_hsa005620.81289129
101ECM-receptor interaction_Homo sapiens_hsa045120.80539117
102Phagosome_Homo sapiens_hsa041450.80022760
103Other glycan degradation_Homo sapiens_hsa005110.79795249
104Viral myocarditis_Homo sapiens_hsa054160.79302416
105Fatty acid elongation_Homo sapiens_hsa000620.79053241
106Dilated cardiomyopathy_Homo sapiens_hsa054140.78630155
107Amoebiasis_Homo sapiens_hsa051460.78286172
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76882187
109Choline metabolism in cancer_Homo sapiens_hsa052310.75205381
110Amphetamine addiction_Homo sapiens_hsa050310.74629858
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74317786
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73962979
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73468972
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72768973
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71569920
116Salmonella infection_Homo sapiens_hsa051320.70874864
117Osteoclast differentiation_Homo sapiens_hsa043800.70767037
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70603624
119Tuberculosis_Homo sapiens_hsa051520.70603257
120Insulin resistance_Homo sapiens_hsa049310.69149596
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66779903
122mTOR signaling pathway_Homo sapiens_hsa041500.66710223
123Viral carcinogenesis_Homo sapiens_hsa052030.66577251
124Malaria_Homo sapiens_hsa051440.66117896
125MicroRNAs in cancer_Homo sapiens_hsa052060.65672651
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.65509975
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65426738
128HTLV-I infection_Homo sapiens_hsa051660.64787876
129Tight junction_Homo sapiens_hsa045300.64537038
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64159268
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.64081398
132Calcium signaling pathway_Homo sapiens_hsa040200.62956768
133Herpes simplex infection_Homo sapiens_hsa051680.62594466
134Proteoglycans in cancer_Homo sapiens_hsa052050.60997871
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60908107
136Fatty acid biosynthesis_Homo sapiens_hsa000610.60563551
137Vibrio cholerae infection_Homo sapiens_hsa051100.60269071
138Thyroid cancer_Homo sapiens_hsa052160.60066004
139Pancreatic cancer_Homo sapiens_hsa052120.59327852
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59306849
141Apoptosis_Homo sapiens_hsa042100.59167041
142Colorectal cancer_Homo sapiens_hsa052100.58836428
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58746111
144Rheumatoid arthritis_Homo sapiens_hsa053230.57785961
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56126462
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55546000
147Melanoma_Homo sapiens_hsa052180.53540148
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.53123386
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52999498
150Small cell lung cancer_Homo sapiens_hsa052220.52593741
151Oocyte meiosis_Homo sapiens_hsa041140.52562548

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »