GNRH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of neurological system process (GO:0031646)9.99723335
2piRNA metabolic process (GO:0034587)9.08557783
3negative regulation of neurological system process (GO:0031645)8.97814160
4polyamine biosynthetic process (GO:0006596)7.59270380
5negative regulation of steroid biosynthetic process (GO:0010894)6.85227967
6negative regulation of potassium ion transport (GO:0043267)6.79289029
7histone H2A monoubiquitination (GO:0035518)6.76013596
8regulation of exit from mitosis (GO:0007096)6.53328844
9negative regulation of smooth muscle cell differentiation (GO:0051151)6.24730951
10negative regulation of steroid metabolic process (GO:0045939)6.19326727
11positive regulation of glucose import (GO:0046326)6.13967863
12mitotic metaphase plate congression (GO:0007080)6.13708474
13histone H2A ubiquitination (GO:0033522)6.11889258
14citrulline biosynthetic process (GO:0019240)6.01910127
15attachment of spindle microtubules to kinetochore (GO:0008608)5.98130263
16pyrimidine nucleobase catabolic process (GO:0006208)5.92441047
17base-excision repair, AP site formation (GO:0006285)5.85216173
18adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.79898575
19negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)5.76312731
20protein K6-linked ubiquitination (GO:0085020)5.75675126
21positive regulation of vesicle fusion (GO:0031340)5.69333616
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.62600396
23eating behavior (GO:0042755)5.50661860
24cellular biogenic amine catabolic process (GO:0042402)5.37629331
25amine catabolic process (GO:0009310)5.37629331
26positive regulation of glucose transport (GO:0010828)5.36883997
27regulation of meiosis (GO:0040020)5.25969520
28female gamete generation (GO:0007292)5.22583586
29meiotic chromosome segregation (GO:0045132)5.17908228
30cellular biogenic amine biosynthetic process (GO:0042401)5.13691853
31acrosome reaction (GO:0007340)5.10308079
32oocyte maturation (GO:0001556)5.08178757
33metaphase plate congression (GO:0051310)5.04210675
34meiotic cell cycle (GO:0051321)4.97604344
35auditory behavior (GO:0031223)4.96155171
36establishment of chromosome localization (GO:0051303)4.93904278
37mitotic chromosome condensation (GO:0007076)4.92117240
38negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.86061963
39amine biosynthetic process (GO:0009309)4.84609809
40male meiosis (GO:0007140)4.84144014
41* regulation of female gonad development (GO:2000194)4.81497016
42regulation of sister chromatid cohesion (GO:0007063)4.78508297
43notochord development (GO:0030903)4.73272313
44DNA methylation involved in gamete generation (GO:0043046)4.72326904
45nucleobase catabolic process (GO:0046113)4.72194744
46pyrimidine nucleotide catabolic process (GO:0006244)4.70346692
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.61187402
48positive regulation of cellular amine metabolic process (GO:0033240)4.54577245
49ectodermal placode formation (GO:0060788)4.54571930
50tooth mineralization (GO:0034505)4.51616007
51negative regulation of meiosis (GO:0045835)4.50874728
52polyamine metabolic process (GO:0006595)4.45516288
53neural crest cell migration (GO:0001755)4.38053082
54regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.36358533
55regulation of glucose import (GO:0046324)4.35080832
56multicellular organism reproduction (GO:0032504)4.30602185
57regulation of glycogen (starch) synthase activity (GO:2000465)4.19892887
58DNA damage induced protein phosphorylation (GO:0006975)4.15866894
59regulation of meiotic cell cycle (GO:0051445)4.03330200
60mitotic sister chromatid segregation (GO:0000070)4.02931115
61regulation of spindle organization (GO:0090224)4.02617400
62mechanosensory behavior (GO:0007638)4.01359492
63negative regulation of reproductive process (GO:2000242)4.00401766
64mitotic sister chromatid cohesion (GO:0007064)3.94162397
65negative regulation of cell killing (GO:0031342)3.92056104
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92056104
67spinal cord development (GO:0021510)3.87358213
68regulation of retinoic acid receptor signaling pathway (GO:0048385)3.83596729
69phosphatidylglycerol biosynthetic process (GO:0006655)3.82971274
70postsynaptic membrane organization (GO:0001941)3.82390616
71regulation of acrosome reaction (GO:0060046)3.81981786
72microtubule severing (GO:0051013)3.81895920
73chromosome segregation (GO:0007059)3.81861094
74positive regulation of megakaryocyte differentiation (GO:0045654)3.76983795
75activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.76199479
76calcium ion-dependent exocytosis (GO:0017156)3.75822323
77oocyte development (GO:0048599)3.75788952
78positive regulation of chromosome segregation (GO:0051984)3.72610287
79gene silencing by RNA (GO:0031047)3.67368908
80regulation of histone H3-K27 methylation (GO:0061085)3.66852768
81CENP-A containing nucleosome assembly (GO:0034080)3.66783733
82regulation of transforming growth factor beta2 production (GO:0032909)3.65751149
83columnar/cuboidal epithelial cell differentiation (GO:0002065)3.65281448
84positive regulation of granulocyte differentiation (GO:0030854)3.64750575
85female gonad development (GO:0008585)3.64244130
86negative regulation of lipid biosynthetic process (GO:0051055)3.61740213
87type B pancreatic cell development (GO:0003323)3.59371339
88N-terminal protein amino acid acetylation (GO:0006474)3.57266325
89regulation of meiosis I (GO:0060631)3.56899126
90maturation of 5.8S rRNA (GO:0000460)3.55418556
91regulation of smooth muscle cell differentiation (GO:0051150)3.55315234
92regulation of protein tyrosine kinase activity (GO:0061097)3.54942692
93response to caffeine (GO:0031000)3.54465676
94resolution of meiotic recombination intermediates (GO:0000712)3.51930668
95chaperone-mediated protein transport (GO:0072321)3.50760600
96positive regulation of meiosis (GO:0045836)3.50574105
97regulation of mitotic spindle organization (GO:0060236)3.50558248
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.48570463
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48570463
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48570463
101neurofilament cytoskeleton organization (GO:0060052)3.44918898
102regulation of vesicle fusion (GO:0031338)3.42589329
103citrulline metabolic process (GO:0000052)3.40147906
104chromatin remodeling at centromere (GO:0031055)3.37396293
105protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)3.37390494
106protein localization to chromosome (GO:0034502)3.37043659
107regulation of RIG-I signaling pathway (GO:0039535)3.36690318
108sister chromatid segregation (GO:0000819)3.36207000
109protein localization to chromosome, centromeric region (GO:0071459)3.35728585
110behavioral response to nicotine (GO:0035095)3.33729239
111negative regulation of cardiac muscle hypertrophy (GO:0010614)3.33324021
112genetic imprinting (GO:0071514)3.32253894
113histone exchange (GO:0043486)3.30578121
114peptidyl-arginine modification (GO:0018195)3.29399651
115regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28956366
116positive regulation of meiotic cell cycle (GO:0051446)3.28936310
117glycerophospholipid catabolic process (GO:0046475)3.28541652
118negative regulation of hormone metabolic process (GO:0032351)3.26047713
119negative regulation of hormone biosynthetic process (GO:0032353)3.26047713
120peptidyl-threonine dephosphorylation (GO:0035970)3.25709664
121regulation of G0 to G1 transition (GO:0070316)3.24397089
122cartilage morphogenesis (GO:0060536)3.22460341
123regulation of telomere maintenance via telomerase (GO:0032210)3.18578129
124succinate metabolic process (GO:0006105)3.18331250
125regulation of potassium ion transport (GO:0043266)3.16913017
126histone monoubiquitination (GO:0010390)3.13906328
127protein localization to kinetochore (GO:0034501)3.13104294
128regulation of DNA methylation (GO:0044030)3.12974627
129pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11789682
130mitochondrion degradation (GO:0000422)3.11547951
131intestinal epithelial cell development (GO:0060576)3.11372776
132fertilization (GO:0009566)3.11021797
133DNA replication-independent nucleosome assembly (GO:0006336)3.11016277
134DNA replication-independent nucleosome organization (GO:0034724)3.11016277
135sphingosine metabolic process (GO:0006670)3.10687176
136regulation of sequestering of triglyceride (GO:0010889)3.09127189
137positive regulation of viral genome replication (GO:0045070)3.08472938
138startle response (GO:0001964)3.08457092
139negative regulation of keratinocyte proliferation (GO:0010839)3.06843249
140dopamine receptor signaling pathway (GO:0007212)3.04862956
141regulation of neurotransmitter secretion (GO:0046928)3.04666068
142sodium ion export (GO:0071436)3.02295010
143cellular response to retinoic acid (GO:0071300)3.02042842
144negative regulation of meiotic cell cycle (GO:0051447)3.01314942
145reproduction (GO:0000003)3.00417464
146regulation of odontogenesis (GO:0042481)3.00033386
147tyrosine phosphorylation of STAT protein (GO:0007260)21.0951759
148nucleoside transmembrane transport (GO:1901642)2.99489001
149positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.99160731
150response to auditory stimulus (GO:0010996)2.99120699
151negative regulation of muscle hypertrophy (GO:0014741)2.98212008
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97445546
153odontogenesis of dentin-containing tooth (GO:0042475)2.96748054
154sister chromatid cohesion (GO:0007062)2.95900948
155regulation of keratinocyte differentiation (GO:0045616)2.92958787
156protein monoubiquitination (GO:0006513)2.92092669
157regulation of chromosome segregation (GO:0051983)2.90929148
158positive regulation of DNA-dependent DNA replication (GO:2000105)2.87885110
159ventricular cardiac muscle cell development (GO:0055015)2.86983031
160heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.83447743
161vocalization behavior (GO:0071625)2.82041312
162transmission of nerve impulse (GO:0019226)2.77372265
163energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75994808
164ATP synthesis coupled proton transport (GO:0015986)2.75994808
165synaptic vesicle maturation (GO:0016188)2.72265917
166dendritic spine morphogenesis (GO:0060997)2.66029742
167regulation of neurotransmitter transport (GO:0051588)2.65504637
168motile cilium assembly (GO:0044458)2.63809066
169regulation of neurological system process (GO:0031644)2.62257175
170respiratory system process (GO:0003016)2.56568661
171negative regulation of cardiac muscle tissue growth (GO:0055022)2.56294688
172negative regulation of heart growth (GO:0061117)2.56294688
173regulation of centrosome duplication (GO:0010824)2.53511777
174cochlea development (GO:0090102)2.52307449
175negative regulation of axon guidance (GO:1902668)2.51231290
176regulation of excitatory postsynaptic membrane potential (GO:0060079)2.48369761
177establishment of mitochondrion localization (GO:0051654)2.45227505
178neuronal ion channel clustering (GO:0045161)2.44292801
179regulation of steroid biosynthetic process (GO:0050810)2.43957522
180iron-sulfur cluster assembly (GO:0016226)2.43508357
181metallo-sulfur cluster assembly (GO:0031163)2.43508357
182positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42647644
183cellular potassium ion homeostasis (GO:0030007)2.41858606
184negative regulation of DNA replication (GO:0008156)2.39189212
185regulation of glucose transport (GO:0010827)2.38584082
186regulation of centrosome cycle (GO:0046605)2.35562815
187isoprenoid biosynthetic process (GO:0008299)2.35265103
188epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35041746
189mitochondrion transport along microtubule (GO:0047497)2.33687560
190establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33687560
191membrane protein intracellular domain proteolysis (GO:0031293)2.33510356
192phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.32432251
193axon extension (GO:0048675)2.30707141
194cGMP-mediated signaling (GO:0019934)2.29593521
195negative regulation of glycogen biosynthetic process (GO:0045719)2.29362226
196cellular response to UV (GO:0034644)2.28588229
197regulation of bile acid biosynthetic process (GO:0070857)19.6953460
198regulation of transmission of nerve impulse (GO:0051969)15.1825707
199negative regulation of protein tyrosine kinase activity (GO:0061099)13.6706064
200response to pheromone (GO:0019236)13.4471536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse6.58327273
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.05135224
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.76278197
4EZH2_22144423_ChIP-Seq_EOC_Human5.67196183
5RBPJ_22232070_ChIP-Seq_NCS_Mouse5.21207755
6SALL1_21062744_ChIP-ChIP_HESCs_Human4.51180210
7E2F7_22180533_ChIP-Seq_HELA_Human4.45259325
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26074350
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.85006825
10KAP1_22055183_ChIP-Seq_ESCs_Mouse3.80772009
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.52191414
12AR_21909140_ChIP-Seq_LNCAP_Human3.49173128
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.41506601
14ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.05365232
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77336072
16VDR_22108803_ChIP-Seq_LS180_Human2.65566111
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.64110552
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.47601168
19DNAJC2_21179169_ChIP-ChIP_NT2_Human2.40173334
20GBX2_23144817_ChIP-Seq_PC3_Human2.34769458
21REST_21632747_ChIP-Seq_MESCs_Mouse2.27731567
22TP53_22127205_ChIP-Seq_IMR90_Human2.23571190
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20488789
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11642215
25TDRD3_21172665_ChIP-Seq_MCF-7_Human2.05177842
26STAT1_20625510_ChIP-Seq_HELA_Human2.04977847
27MYC_18940864_ChIP-ChIP_HL60_Human1.95287335
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.89527526
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.88016594
30ER_23166858_ChIP-Seq_MCF-7_Human1.82081642
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.80518830
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78023288
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.77837947
34AR_21572438_ChIP-Seq_LNCaP_Human1.76477815
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.66021162
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64825940
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64145778
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.63877540
39RNF2_27304074_Chip-Seq_NSC_Mouse1.63103512
40RUNX1_26923725_Chip-Seq_HPCs_Mouse1.59914166
41* STAT1_17558387_ChIP-Seq_HELA_Human1.55749546
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.52573545
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50981649
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.50250695
45JUN_21703547_ChIP-Seq_K562_Human1.50003758
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49067919
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.47198373
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46956090
49CDX2_22108803_ChIP-Seq_LS180_Human1.46313684
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.46286711
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44376669
52TP53_22573176_ChIP-Seq_HFKS_Human1.43105538
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.42928211
54TAF15_26573619_Chip-Seq_HEK293_Human1.42727999
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42202376
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41753839
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.41374006
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39695748
59ZNF274_21170338_ChIP-Seq_K562_Hela1.39481041
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34999133
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.34229293
62HTT_18923047_ChIP-ChIP_STHdh_Human1.33691028
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32291446
64REST_19997604_ChIP-ChIP_NEURONS_Mouse1.31698650
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31693764
66SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31521156
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31493625
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27896670
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.27709647
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27037682
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26187788
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.25850241
73MYC_19829295_ChIP-Seq_ESCs_Human1.25473847
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24882019
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24857181
76NANOG_19829295_ChIP-Seq_ESCs_Human1.24710713
77SOX2_19829295_ChIP-Seq_ESCs_Human1.24710713
78CTCF_27219007_Chip-Seq_Bcells_Human1.23937307
79SMRT_27268052_Chip-Seq_Bcells_Human1.23372370
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22448730
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21578047
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21329758
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.20745130
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.20439796
85GF1B_26923725_Chip-Seq_HPCs_Mouse1.20151000
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19153703
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.19114321
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18776751
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18690965
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18577187
91P300_19829295_ChIP-Seq_ESCs_Human1.17937187
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17527408
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17399636
94IGF1R_20145208_ChIP-Seq_DFB_Human1.16473843
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15224583
96EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13474669
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13474669
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13393570
99AR_25329375_ChIP-Seq_VCAP_Human1.12798773
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12288133
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.11853120
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.11745031
103CJUN_26792858_Chip-Seq_BT549_Human1.10210747
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.09684826
105CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09438425
106SPI1_20517297_ChIP-Seq_HL60_Human1.09119282
107EGR1_19032775_ChIP-ChIP_M12_Human1.09068923
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08887220
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08499132
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08159154
111NCOR_22424771_ChIP-Seq_293T_Human1.07618090
112NFYA_21822215_ChIP-Seq_K562_Human1.06866052
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.06747302
114GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06376859
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06239172
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05052285
117AR_19668381_ChIP-Seq_PC3_Human1.05015754
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04880750
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.04450435
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03812499
121FOXH1_21741376_ChIP-Seq_EPCs_Human1.03759184
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03264053
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02775430
124CBP_20019798_ChIP-Seq_JUKART_Human1.02006110
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02006110
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01755309
127HNFA_21074721_ChIP-Seq_CACO-2_Human1.01637089
128* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01631882
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01409211
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.00589229
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.99135342
132GATA3_26560356_Chip-Seq_TH1_Human0.98540205
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98461571
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98090557
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97937640
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97729814
137EWS_26573619_Chip-Seq_HEK293_Human0.97433278
138ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97081452
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96915712
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96667778
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96205040
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96128132
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.95178166
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.94793128
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.94737754
146GATA3_27048872_Chip-Seq_THYMUS_Human0.93013418
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.92775602
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92168801
149FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91977101
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91958760
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.91938502
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91424328
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91155080
154OCT4_19829295_ChIP-Seq_ESCs_Human0.90356715
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.90301042
156ETV1_20927104_ChIP-Seq_GIST48_Human0.90254307
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.89762978
158FUS_26573619_Chip-Seq_HEK293_Human0.89286929
159RBPJ_21746931_ChIP-Seq_IB4_Human0.89092705
160EED_16625203_ChIP-ChIP_MESCs_Mouse0.89091022
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88925699
162SOX2_16153702_ChIP-ChIP_HESCs_Human0.88774377
163SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88167885
164RING1B_27294783_Chip-Seq_ESCs_Mouse0.88105788
165PHF8_20622853_ChIP-Seq_HELA_Human0.87637992
166VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87536979
167ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87283367
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.87101606
169P53_22387025_ChIP-Seq_ESCs_Mouse0.86812236
170KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86170424
171TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86103895
172* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85944861
173GATA6_21074721_ChIP-Seq_CACO-2_Human0.84354801
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84273759
175NANOG_20526341_ChIP-Seq_ESCs_Human0.83927963
176MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83899765
177SOX2_18555785_Chip-Seq_ESCs_Mouse0.83384173
178KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83136188
179SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82222272
180PRDM14_20953172_ChIP-Seq_ESCs_Human0.82124161
181CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81983391
182KDM2B_26808549_Chip-Seq_REH_Human0.81667593
183PHF8_20622854_ChIP-Seq_HELA_Human0.81384543
184CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80026559
185CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79822787
186SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79819233
187CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79567323
188MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78788425
189KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77962983
190CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76805687
191FOXH1_21741376_ChIP-Seq_ESCs_Human0.74922906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.69948068
2MP0002254_reproductive_system_inflammat6.21252112
3MP0003718_maternal_effect6.15950684
4MP0003122_maternal_imprinting5.12017311
5MP0003693_abnormal_embryo_hatching4.34798055
6MP0008877_abnormal_DNA_methylation4.22188569
7MP0001348_abnormal_lacrimal_gland4.16126283
8MP0001984_abnormal_olfaction3.71541248
9MP0005451_abnormal_body_composition3.43947863
10MP0005395_other_phenotype2.76624708
11MP0009046_muscle_twitch2.76059104
12MP0003699_abnormal_female_reproductive2.74107357
13MP0000537_abnormal_urethra_morphology2.66681336
14MP0003077_abnormal_cell_cycle2.63045835
15* MP0001119_abnormal_female_reproductive2.54888985
16MP0002272_abnormal_nervous_system2.53053537
17MP0002876_abnormal_thyroid_physiology2.50839166
18MP0005257_abnormal_intraocular_pressure2.48563784
19MP0004859_abnormal_synaptic_plasticity2.40337441
20MP0010094_abnormal_chromosome_stability2.38067088
21MP0004957_abnormal_blastocyst_morpholog2.35118100
22MP0002282_abnormal_trachea_morphology2.34221042
23MP0003656_abnormal_erythrocyte_physiolo2.25807757
24MP0000579_abnormal_nail_morphology2.23806309
25MP0003879_abnormal_hair_cell2.22566013
26MP0003787_abnormal_imprinting2.21729963
27MP0003111_abnormal_nucleus_morphology2.16822329
28MP0003880_abnormal_central_pattern2.13074010
29MP0008057_abnormal_DNA_replication2.09012088
30MP0004130_abnormal_muscle_cell2.08416227
31MP0003937_abnormal_limbs/digits/tail_de2.08384944
32* MP0001929_abnormal_gametogenesis2.07407990
33MP0003123_paternal_imprinting2.03895274
34MP0004133_heterotaxia1.91714541
35MP0003950_abnormal_plasma_membrane1.87665662
36MP0001873_stomach_inflammation1.87495882
37MP0002249_abnormal_larynx_morphology1.87355096
38* MP0000653_abnormal_sex_gland1.85826830
39* MP0002210_abnormal_sex_determination1.85707608
40MP0002102_abnormal_ear_morphology1.85540115
41MP0002653_abnormal_ependyma_morphology1.68632886
42MP0003635_abnormal_synaptic_transmissio1.67806916
43MP0002736_abnormal_nociception_after1.61166760
44MP0003283_abnormal_digestive_organ1.59769604
45MP0005408_hypopigmentation1.50714276
46MP0001177_atelectasis1.49665187
47MP0000432_abnormal_head_morphology1.49664008
48MP0005423_abnormal_somatic_nervous1.46951798
49MP0000049_abnormal_middle_ear1.43446195
50MP0003121_genomic_imprinting1.43382990
51MP0000462_abnormal_digestive_system1.43109148
52MP0009745_abnormal_behavioral_response1.42818916
53MP0001849_ear_inflammation1.42294329
54MP0005535_abnormal_body_temperature1.41459729
55MP0002064_seizures1.40539075
56MP0006292_abnormal_olfactory_placode1.37943998
57MP0003935_abnormal_craniofacial_develop1.37778634
58MP0000778_abnormal_nervous_system1.37592568
59MP0000230_abnormal_systemic_arterial1.35043604
60MP0001529_abnormal_vocalization1.33615243
61MP0002161_abnormal_fertility/fecundity1.33347754
62MP0002063_abnormal_learning/memory/cond1.31035481
63MP0008932_abnormal_embryonic_tissue1.29205264
64MP0001968_abnormal_touch/_nociception1.28782701
65MP0003115_abnormal_respiratory_system1.26446765
66MP0005310_abnormal_salivary_gland1.25177724
67MP0003763_abnormal_thymus_physiology1.22726836
68MP0002184_abnormal_innervation1.22101982
69MP0005360_urolithiasis1.22063258
70MP0009250_abnormal_appendicular_skeleto1.21869360
71MP0002163_abnormal_gland_morphology1.20684945
72* MP0001145_abnormal_male_reproductive1.18423710
73MP0002557_abnormal_social/conspecific_i1.17529457
74MP0000685_abnormal_immune_system1.15992866
75MP0002733_abnormal_thermal_nociception1.15475936
76MP0003755_abnormal_palate_morphology1.12632215
77MP0001970_abnormal_pain_threshold1.11456808
78MP0005499_abnormal_olfactory_system1.10935802
79MP0005394_taste/olfaction_phenotype1.10935802
80MP0001943_abnormal_respiration1.10856650
81MP0000477_abnormal_intestine_morphology1.10848616
82MP0003221_abnormal_cardiomyocyte_apopto1.09617390
83MP0000163_abnormal_cartilage_morphology1.09242557
84MP0008961_abnormal_basal_metabolism1.09057483
85MP0000350_abnormal_cell_proliferation1.07790731
86MP0004264_abnormal_extraembryonic_tissu1.05323905
87MP0009333_abnormal_splenocyte_physiolog1.05306774
88MP0002109_abnormal_limb_morphology1.04764154
89MP0002115_abnormal_skeleton_extremities1.04332785
90MP0002295_abnormal_pulmonary_circulatio1.03916639
91MP0000538_abnormal_urinary_bladder1.03469756
92MP0004085_abnormal_heartbeat1.02837328
93MP0000490_abnormal_crypts_of1.01728676
94MP0008789_abnormal_olfactory_epithelium1.01569272
95MP0000465_gastrointestinal_hemorrhage1.00983837
96MP0006276_abnormal_autonomic_nervous1.00193259
97MP0008007_abnormal_cellular_replicative0.99788189
98MP0002877_abnormal_melanocyte_morpholog0.98965198
99MP0002572_abnormal_emotion/affect_behav0.97285517
100MP0000955_abnormal_spinal_cord0.96412846
101MP0009384_cardiac_valve_regurgitation0.94559879
102MP0001502_abnormal_circadian_rhythm0.94307117
103MP0001730_embryonic_growth_arrest0.94176129
104MP0001346_abnormal_lacrimal_gland0.93972692
105MP0004484_altered_response_of0.92596092
106MP0004147_increased_porphyrin_level0.92460946
107MP0003091_abnormal_cell_migration0.91440544
108MP0002113_abnormal_skeleton_development0.91121709
109MP0000678_abnormal_parathyroid_gland0.90754243
110MP0004185_abnormal_adipocyte_glucose0.90716261
111* MP0002019_abnormal_tumor_incidence0.90673747
112MP0002277_abnormal_respiratory_mucosa0.89550205
113MP0005389_reproductive_system_phenotype0.88111149
114MP0002160_abnormal_reproductive_system0.88107263
115MP0000639_abnormal_adrenal_gland0.87328185
116MP0009697_abnormal_copulation0.87132585
117MP0010368_abnormal_lymphatic_system0.85384413
118MP0003938_abnormal_ear_development0.85185008
119MP0002085_abnormal_embryonic_tissue0.85121793
120MP0002116_abnormal_craniofacial_bone0.83771903
121MP0001905_abnormal_dopamine_level0.83397121
122MP0002089_abnormal_postnatal_growth/wei0.82025640
123MP0009053_abnormal_anal_canal0.81370005
124MP0003453_abnormal_keratinocyte_physiol0.79754009
125MP0002882_abnormal_neuron_morphology0.78839044
126MP0009379_abnormal_foot_pigmentation0.78697646
127MP0008875_abnormal_xenobiotic_pharmacok0.78445332
128MP0001188_hyperpigmentation0.77700046
129MP0002752_abnormal_somatic_nervous0.77406515
130MP0004782_abnormal_surfactant_physiolog0.76992591
131MP0002332_abnormal_exercise_endurance0.76945574
132MP0004811_abnormal_neuron_physiology0.76808321
133MP0001915_intracranial_hemorrhage0.76544464
134MP0002933_joint_inflammation0.76529554
135MP0001440_abnormal_grooming_behavior0.76131359
136MP0005621_abnormal_cell_physiology0.75732601
137MP0001299_abnormal_eye_distance/0.75254717
138MP0004142_abnormal_muscle_tone0.75118851
139MP0006082_CNS_inflammation0.74914462
140MP0004924_abnormal_behavior0.74840567
141MP0005386_behavior/neurological_phenoty0.74840567
142MP0002127_abnormal_cardiovascular_syste0.74046418
143MP0010386_abnormal_urinary_bladder0.73218571
144MP0000767_abnormal_smooth_muscle0.72290457
145MP0002139_abnormal_hepatobiliary_system0.71558201
146MP0005645_abnormal_hypothalamus_physiol0.71236470
147MP0005332_abnormal_amino_acid0.70985793
148* MP0000689_abnormal_spleen_morphology0.69965016
149MP0005551_abnormal_eye_electrophysiolog0.69958584
150MP0001851_eye_inflammation0.69064436
151MP0002066_abnormal_motor_capabilities/c0.68997541
152MP0000470_abnormal_stomach_morphology0.68916263
153MP0005381_digestive/alimentary_phenotyp0.67378725
154MP0003942_abnormal_urinary_system0.66071706
155MP0003959_abnormal_lean_body0.64870555
156* MP0002398_abnormal_bone_marrow0.63053503
157MP0005380_embryogenesis_phenotype0.62787498
158MP0001672_abnormal_embryogenesis/_devel0.62787498
159MP0002067_abnormal_sensory_capabilities0.62743233
160MP0005464_abnormal_platelet_physiology0.61778081
161MP0003045_fibrosis0.61532991
162MP0005195_abnormal_posterior_eye0.60154389
163MP0002396_abnormal_hematopoietic_system0.59159924
164MP0000703_abnormal_thymus_morphology0.58648870
165MP0001542_abnormal_bone_strength0.57670929
166MP0002177_abnormal_outer_ear0.56617503
167MP0002734_abnormal_mechanical_nocicepti0.56305573
168MP0002069_abnormal_eating/drinking_beha0.56134153
169* MP0000613_abnormal_salivary_gland0.55666950
170MP0002152_abnormal_brain_morphology0.55486770
171MP0001697_abnormal_embryo_size0.55432625
172MP0002269_muscular_atrophy0.55014870
173MP0004036_abnormal_muscle_relaxation0.54470349
174MP0003698_abnormal_male_reproductive0.54379701
175MP0000343_altered_response_to0.53848415
176MP0002722_abnormal_immune_system0.53218719
177MP0001486_abnormal_startle_reflex0.52641980
178MP0002229_neurodegeneration0.52519284
179MP0000762_abnormal_tongue_morphology0.52361826
180MP0009780_abnormal_chondrocyte_physiolo0.52289498

Predicted human phenotypes

RankGene SetZ-score
1Large eyes (HP:0001090)6.76400182
2Flat capital femoral epiphysis (HP:0003370)6.57443066
3Male infertility (HP:0003251)6.20667257
4Urinary bladder sphincter dysfunction (HP:0002839)6.00995880
5Irregular epiphyses (HP:0010582)5.99032959
6Limb dystonia (HP:0002451)5.77541829
7Stenosis of the external auditory canal (HP:0000402)5.61714351
8Agitation (HP:0000713)5.21486544
9Asplenia (HP:0001746)4.78797656
10Aplasia/Hypoplasia of the spleen (HP:0010451)4.66091199
11Small epiphyses (HP:0010585)4.29874387
12Broad distal phalanx of finger (HP:0009836)4.28997421
13Progressive cerebellar ataxia (HP:0002073)4.24233297
14Chronic hepatic failure (HP:0100626)4.15651188
15Microretrognathia (HP:0000308)3.97665356
16Urinary urgency (HP:0000012)3.93033021
17Macroorchidism (HP:0000053)3.78787265
18Vitreoretinal degeneration (HP:0000655)3.75716653
19Amblyopia (HP:0000646)3.74500703
20Abnormality of calcium-phosphate metabolism (HP:0100530)3.73135074
21Adrenal hypoplasia (HP:0000835)3.72716123
22Epiphyseal dysplasia (HP:0002656)3.72049624
23Cortical dysplasia (HP:0002539)3.68351566
24Onycholysis (HP:0001806)3.65091621
25Cupped ribs (HP:0000887)3.62314518
26Chromsome breakage (HP:0040012)3.58084700
27Metaphyseal cupping (HP:0003021)3.49518027
28Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.46989674
29Abnormality of femoral epiphyses (HP:0006499)3.46989674
30Papillary thyroid carcinoma (HP:0002895)3.42481286
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39286316
32Birth length less than 3rd percentile (HP:0003561)3.37549612
33Abnormality of the epiphysis of the femoral head (HP:0010574)3.37266754
34Optic nerve coloboma (HP:0000588)3.35536753
35Lissencephaly (HP:0001339)3.34717925
36Genetic anticipation (HP:0003743)3.32836027
37Breast hypoplasia (HP:0003187)3.31600267
38Infertility (HP:0000789)3.24841293
39Delayed epiphyseal ossification (HP:0002663)3.24032004
40Abnormality of the femoral head (HP:0003368)3.23174118
41Patent foramen ovale (HP:0001655)3.21972043
42Elevated erythrocyte sedimentation rate (HP:0003565)3.17104232
43Severe Myopia (HP:0011003)3.16459712
44Peritonitis (HP:0002586)3.03060634
45Dynein arm defect of respiratory motile cilia (HP:0012255)3.02377765
46Absent/shortened dynein arms (HP:0200106)3.02377765
47Secondary amenorrhea (HP:0000869)3.00787522
48Enlarged penis (HP:0000040)3.00404799
49Hyperphosphatemia (HP:0002905)3.00272525
50Chronic bronchitis (HP:0004469)3.00014768
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.96041876
52Absent epiphyses (HP:0010577)2.96041876
53Patellar aplasia (HP:0006443)2.87282339
54Restlessness (HP:0000711)2.82366554
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.81666792
56Abnormal tarsal ossification (HP:0008369)2.81207889
57Nephronophthisis (HP:0000090)2.81124432
58Abnormality of the proximal phalanges of the hand (HP:0009834)2.78663775
59Impaired vibration sensation in the lower limbs (HP:0002166)2.77917873
60Spastic gait (HP:0002064)2.77864360
61Milia (HP:0001056)2.77670168
62Aplasia/Hypoplasia of the patella (HP:0006498)2.77168937
63Hypoplastic ischia (HP:0003175)2.73948009
64Hypoplasia of the brainstem (HP:0002365)2.72676861
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.72676861
66Hypercortisolism (HP:0001578)2.69128619
67Abnormality of midbrain morphology (HP:0002418)2.69119170
68Molar tooth sign on MRI (HP:0002419)2.69119170
69Premature ovarian failure (HP:0008209)2.68009038
70Testicular atrophy (HP:0000029)2.67055743
71Fragile nails (HP:0001808)2.65800112
72Abnormality of the vertebral endplates (HP:0005106)2.61483697
73Partial agenesis of the corpus callosum (HP:0001338)2.61385121
74Combined immunodeficiency (HP:0005387)2.60401146
75Aplasia/Hypoplasia of the breasts (HP:0010311)2.59132476
76Retinal dysplasia (HP:0007973)2.58522381
77Autoamputation (HP:0001218)2.57624044
78Breast aplasia (HP:0100783)2.55122178
79Stillbirth (HP:0003826)2.54042652
80Irregular vertebral endplates (HP:0003301)2.53649093
81Genu varum (HP:0002970)2.53282744
82Spondylolisthesis (HP:0003302)2.53237031
83Abnormality of the renal medulla (HP:0100957)2.53101317
84Metaphyseal irregularity (HP:0003025)2.52465909
85Hypergonadotropic hypogonadism (HP:0000815)2.52270986
86Pulmonary fibrosis (HP:0002206)2.50371490
87Ankle clonus (HP:0011448)2.50140446
88Arterial tortuosity (HP:0005116)2.49409432
89Atrophic scars (HP:0001075)2.45371946
90Abnormal foot bone ossification (HP:0010675)2.41399265
91Short femoral neck (HP:0100864)2.39602950
92Enlarged kidneys (HP:0000105)2.37946650
93Hypoplastic iliac wings (HP:0002866)2.37926044
94Bicuspid aortic valve (HP:0001647)2.36014074
95Hypoplastic pelvis (HP:0008839)2.34884631
96Renal cortical cysts (HP:0000803)2.33364382
97Torticollis (HP:0000473)2.31463000
98Pachygyria (HP:0001302)2.29643217
99Microtia (HP:0008551)2.25252120
100Mild short stature (HP:0003502)2.21991405
101Abnormality of the renal cortex (HP:0011035)2.21534215
102Abnormality of cochlea (HP:0000375)2.21384135
103Tubular atrophy (HP:0000092)2.20588357
104Shawl scrotum (HP:0000049)2.19394443
105Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18515004
106Nonprogressive disorder (HP:0003680)2.16849860
107Abnormality of the ischium (HP:0003174)2.15838212
108Cystic hygroma (HP:0000476)2.15126907
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15034689
110Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.14901964
111Bifid uvula (HP:0000193)2.14479929
112Vascular tortuosity (HP:0004948)2.14256909
113Flat acetabular roof (HP:0003180)2.12835160
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12585648
115Pancreatic fibrosis (HP:0100732)2.12408542
116Congenital hepatic fibrosis (HP:0002612)2.12095222
117Abnormality of placental membranes (HP:0011409)2.11054747
118Amniotic constriction ring (HP:0009775)2.11054747
119Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10727374
120True hermaphroditism (HP:0010459)2.10662174
121Focal dystonia (HP:0004373)2.09020314
122Aplastic anemia (HP:0001915)2.07803317
123Abnormality of the fovea (HP:0000493)2.07315464
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07281679
125Type 2 muscle fiber atrophy (HP:0003554)2.06904595
126Severe combined immunodeficiency (HP:0004430)2.04668213
127Occipital encephalocele (HP:0002085)2.04505513
128Muscle stiffness (HP:0003552)2.02494433
129Weak cry (HP:0001612)2.02398032
130Dysphonia (HP:0001618)2.01814008
131Muscle fiber atrophy (HP:0100295)2.00349756
132Amelogenesis imperfecta (HP:0000705)10.3070337
133Abnormality of incisor morphology (HP:0011063)1.99382394
134Down-sloping shoulders (HP:0200021)1.99368949
135Menstrual irregularities (HP:0000858)1.99146314
136Flattened epiphyses (HP:0003071)1.98349775
137Tubulointerstitial nephritis (HP:0001970)1.97999508
138Barrel-shaped chest (HP:0001552)1.97336267
139Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96724750
140Thin ribs (HP:0000883)1.96585488
141Calcaneovalgus deformity (HP:0001848)1.96503554
142Medial flaring of the eyebrow (HP:0010747)1.96189712
143Memory impairment (HP:0002354)1.95173513
144Abnormality of magnesium homeostasis (HP:0004921)1.93829387
145Akinesia (HP:0002304)1.93203631
146Tubulointerstitial abnormality (HP:0001969)1.92864685
147Abnormality of the labia minora (HP:0012880)1.92597720
148Fetal akinesia sequence (HP:0001989)1.92408757
149Abdominal situs inversus (HP:0003363)1.90393222
150Abnormality of abdominal situs (HP:0011620)1.90393222
151Generalized hypotonia (HP:0001290)1.90234500
152Coxa vara (HP:0002812)1.89930558
153Long clavicles (HP:0000890)1.89659028
154Abnormality of the neuromuscular junction (HP:0003398)1.89436708
155Fatigable weakness (HP:0003473)1.89436708
156Renal Fanconi syndrome (HP:0001994)1.88681299
157Short nail (HP:0001799)1.88582777
158Epileptic encephalopathy (HP:0200134)1.87515929
159Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86250327
160Congenital glaucoma (HP:0001087)1.85910485
161Carpal bone hypoplasia (HP:0001498)1.85629674
162Hypoplasia of the fovea (HP:0007750)1.85006131
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.85006131
164Meckel diverticulum (HP:0002245)1.84398254
165Hyperthyroidism (HP:0000836)1.83886829
166Abnormal drinking behavior (HP:0030082)1.83511004
167Polydipsia (HP:0001959)1.83511004
168Morphological abnormality of the middle ear (HP:0008609)1.83380458
169Hypoalbuminemia (HP:0003073)1.83228191
170Abnormal albumin level (HP:0012116)1.83228191
171Insulin-resistant diabetes mellitus (HP:0000831)1.82025234
172Arthropathy (HP:0003040)1.79656858
173Abnormality of the intervertebral disk (HP:0005108)1.79627674
174Thyroiditis (HP:0100646)1.79477946
175Heterotopia (HP:0002282)1.79469683
176Esotropia (HP:0000565)1.79364154
177Acute myeloid leukemia (HP:0004808)1.77353306
178Optic nerve hypoplasia (HP:0000609)1.77049891
179Hypoplastic ilia (HP:0000946)1.75616710
180Abnormality of chromosome segregation (HP:0002916)1.75488210
181Atelectasis (HP:0100750)1.74276384
182Metaphyseal dysplasia (HP:0100255)1.74223126
183Absent frontal sinuses (HP:0002688)1.74209860
184Hypomagnesemia (HP:0002917)1.73871755
185Vertebral clefting (HP:0008428)1.73704889
186Tubulointerstitial fibrosis (HP:0005576)1.72964401
187Abnormality of lateral ventricle (HP:0030047)1.71178750
188Abnormality of the corticospinal tract (HP:0002492)1.70898146
189Keratoconjunctivitis (HP:0001096)1.70864795
190Abnormal respiratory motile cilium morphology (HP:0005938)1.70142909
191Abnormal respiratory epithelium morphology (HP:0012253)1.70142909
192Lip pit (HP:0100267)1.68584712
193Deformed tarsal bones (HP:0008119)1.68011093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.99671558
2ERBB44.53989990
3IRAK14.42301555
4LATS14.08914875
5TNIK3.95063307
6STK38L2.91793799
7TAOK32.86568666
8LATS22.78599511
9MUSK2.73173842
10MINK12.54420323
11EEF2K2.52051811
12KSR22.42566719
13STK32.39489654
14CASK2.31715422
15PLK42.18279373
16PRKD32.02741826
17LIMK12.00108285
18PTK610.7050141
19ARAF1.98819397
20CDK81.97669788
21STK101.94958781
22TTK1.93526898
23NTRK21.90900661
24PRKCH1.88098683
25TRPM71.87497567
26MOS1.87165656
27BRAF1.82924175
28MAP3K131.74485436
29CDC71.74318232
30PAK31.68464005
31STK241.67156058
32DYRK31.66327261
33TAOK11.62683431
34MELK1.62613354
35MAPKAPK31.61947062
36RAF11.58550416
37BRSK21.55935347
38RIPK11.55875320
39CHEK21.43402233
40NEK21.43116811
41SIK11.42378910
42PLK11.40342144
43LYN1.34698440
44MAP3K91.34378860
45CDK91.32622460
46BMPR21.30337258
47EIF2AK11.30064302
48NLK1.22158826
49ROCK21.19951708
50PRKCG1.18548177
51BUB11.12137986
52PLK31.02432117
53VRK11.01315357
54ICK1.00118659
55SGK30.99316381
56JAK30.98107394
57MAPKAPK50.97779683
58NUAK10.92312861
59SGK2230.91533782
60SGK4940.91533782
61MAP3K80.91448022
62DMPK0.91082074
63PRKCI0.87565467
64AURKB0.79757110
65MST40.79687583
66ILK0.79475252
67ADRBK10.79366310
68MAP3K40.78755375
69WNK40.76462161
70MAPK130.76084179
71ABL20.74364874
72PRKD20.73949415
73MAP3K50.73178783
74MAP2K40.72956995
75MAP3K30.72541782
76CAMK1D0.72251732
77PIM10.71557774
78STK40.71474901
79PRKCZ0.71302816
80MAP2K60.70584111
81BRSK10.69507816
82DYRK20.69498385
83ADRBK20.68544468
84ROCK10.66642764
85STK110.66414199
86EPHA40.65217101
87FRK0.64052989
88MAP3K140.63748123
89CDK120.63156078
90MAP2K70.62253042
91TXK0.61494336
92CDK30.61026148
93AURKA0.60339086
94PRPF4B0.59033766
95PRKCE0.57797982
96PRKAA10.56861960
97SGK10.56833680
98ABL10.56376990
99CHUK0.54275849
100CHEK10.52914697
101MARK10.52397495
102GRK10.52206773
103PRKCQ0.51603553
104MAP4K10.51074731
105CSNK1G30.51032918
106WEE10.50606339
107CSNK1G10.50235877
108RPS6KA20.50225365
109RET0.49201202
110PRKAA20.46791963
111CSNK1G20.45474863
112MAPK110.45298437
113ATM0.44526015
114CSNK1A1L0.44372769
115MYLK0.43830316
116MAP2K30.42956620
117WNK30.41971744
118PINK10.41392377
119PLK20.40782489
120TYK20.39315904
121NEK90.39275995
122CAMK1G0.38830133
123CSNK1E0.38288992
124CDK50.38264289
125CDK40.37588434
126PRKG10.37293255
127PRKCD0.36483300
128RIPK40.35203617
129STK380.33687528
130DYRK1A0.32941150
131PRKACB0.31881669
132CDK70.31687121
133CDK190.31187193
134CSNK1A10.30962607
135ERBB30.30777054
136PRKDC0.30702477
137DDR20.30248256
138RPS6KB20.30016835
139MAPK80.29961345
140RPS6KA10.29876965
141MAP3K10.29790068
142JAK10.29165910
143TESK20.28845871
144PAK60.28568241
145CDK10.28472422
146PTK2B0.27498006
147KSR10.26331123
148IKBKE0.26184044
149ALK0.25536279
150RPS6KA60.25420961
151PRKACA0.25368889
152PRKCB0.25366257
153WNK10.25081460
154DAPK20.24688331
155CDC42BPA0.24028847
156CSF1R0.24000445
157CDK20.23892031
158PTK20.23564180
159TIE10.23353884
160KIT0.23077104
161TGFBR20.22888306
162CSK0.22647872
163TYRO30.22634881
164NEK60.21879540
165PRKG20.21272260
166RPS6KA50.19676310
167SGK20.19628515
168RPS6KA30.19255248
169CSNK2A20.19017717
170GSK3A0.18828171
171GSK3B0.17963823
172PRKCA0.17956987
173SIK20.17831265
174AKT10.17619276
175CAMK2A0.17522504
176IRAK40.17446784
177MATK0.17219035
178MARK20.17047330
179CDK140.16511165
180DYRK1B0.15472516

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.91645693
2RNA degradation_Homo sapiens_hsa030183.68381039
3Cell cycle_Homo sapiens_hsa041103.65564830
4Ovarian steroidogenesis_Homo sapiens_hsa049133.65393484
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.55187100
6Basal transcription factors_Homo sapiens_hsa030223.32637181
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.27503364
8Vitamin B6 metabolism_Homo sapiens_hsa007503.14676416
9Melanoma_Homo sapiens_hsa052182.98933825
10Synaptic vesicle cycle_Homo sapiens_hsa047212.85865986
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.73760999
12RNA polymerase_Homo sapiens_hsa030202.37342136
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31751609
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.25444733
15Pancreatic cancer_Homo sapiens_hsa052122.15668344
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12949160
17beta-Alanine metabolism_Homo sapiens_hsa004102.12715362
18Oocyte meiosis_Homo sapiens_hsa041142.01328772
19Fanconi anemia pathway_Homo sapiens_hsa034601.98847353
20Nicotine addiction_Homo sapiens_hsa050331.97628370
21RNA transport_Homo sapiens_hsa030131.96109912
22Dorso-ventral axis formation_Homo sapiens_hsa043201.89603487
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89568363
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89537120
25Homologous recombination_Homo sapiens_hsa034401.87767906
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84003288
27Ether lipid metabolism_Homo sapiens_hsa005651.79868293
28TGF-beta signaling pathway_Homo sapiens_hsa043501.78802240
29Linoleic acid metabolism_Homo sapiens_hsa005911.75835479
30Cardiac muscle contraction_Homo sapiens_hsa042601.74581938
31Dopaminergic synapse_Homo sapiens_hsa047281.73927680
32Other glycan degradation_Homo sapiens_hsa005111.69532082
33Mineral absorption_Homo sapiens_hsa049781.64433282
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63380270
35GABAergic synapse_Homo sapiens_hsa047271.62672927
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62246443
37ECM-receptor interaction_Homo sapiens_hsa045121.60957236
38Peroxisome_Homo sapiens_hsa041461.60668966
39Butanoate metabolism_Homo sapiens_hsa006501.58521661
40p53 signaling pathway_Homo sapiens_hsa041151.53288111
41MicroRNAs in cancer_Homo sapiens_hsa052061.53288064
42Type I diabetes mellitus_Homo sapiens_hsa049401.47696048
43Axon guidance_Homo sapiens_hsa043601.46564378
44Insulin secretion_Homo sapiens_hsa049111.43427641
45MAPK signaling pathway_Homo sapiens_hsa040101.43088961
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41384184
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41063642
48Base excision repair_Homo sapiens_hsa034101.35339499
49Colorectal cancer_Homo sapiens_hsa052101.34449844
50Circadian rhythm_Homo sapiens_hsa047101.32889471
51Parkinsons disease_Homo sapiens_hsa050121.31354758
52Selenocompound metabolism_Homo sapiens_hsa004501.29968815
53Sphingolipid metabolism_Homo sapiens_hsa006001.28555800
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28236145
55Small cell lung cancer_Homo sapiens_hsa052221.27750560
56Rap1 signaling pathway_Homo sapiens_hsa040151.26188021
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25593425
58Morphine addiction_Homo sapiens_hsa050321.18530442
59Malaria_Homo sapiens_hsa051441.17071210
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14354812
61* GnRH signaling pathway_Homo sapiens_hsa049121.13564065
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12057696
63mRNA surveillance pathway_Homo sapiens_hsa030151.09477640
64Prolactin signaling pathway_Homo sapiens_hsa049171.08956225
65Cocaine addiction_Homo sapiens_hsa050301.08864814
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07824618
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07248179
68Phototransduction_Homo sapiens_hsa047441.06647571
69Glutamatergic synapse_Homo sapiens_hsa047241.06605389
70Shigellosis_Homo sapiens_hsa051311.04692939
71Gastric acid secretion_Homo sapiens_hsa049710.99835384
72Glycerolipid metabolism_Homo sapiens_hsa005610.97124454
73Bladder cancer_Homo sapiens_hsa052190.94911136
74Circadian entrainment_Homo sapiens_hsa047130.93702390
75Choline metabolism in cancer_Homo sapiens_hsa052310.92485909
76Nucleotide excision repair_Homo sapiens_hsa034200.91881413
77Renal cell carcinoma_Homo sapiens_hsa052110.91647691
78Long-term depression_Homo sapiens_hsa047300.90503717
79Hepatitis B_Homo sapiens_hsa051610.89209262
80Platelet activation_Homo sapiens_hsa046110.89033268
81VEGF signaling pathway_Homo sapiens_hsa043700.88733432
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88569995
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.87250977
84Chronic myeloid leukemia_Homo sapiens_hsa052200.86844980
85Oxytocin signaling pathway_Homo sapiens_hsa049210.85572196
86Mismatch repair_Homo sapiens_hsa034300.84472839
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83572458
88Fatty acid biosynthesis_Homo sapiens_hsa000610.83103682
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82798674
90Primary immunodeficiency_Homo sapiens_hsa053400.82309460
91Thyroid hormone synthesis_Homo sapiens_hsa049180.81861094
92FoxO signaling pathway_Homo sapiens_hsa040680.80931309
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80576335
94DNA replication_Homo sapiens_hsa030300.79977603
95Oxidative phosphorylation_Homo sapiens_hsa001900.78176679
96Protein export_Homo sapiens_hsa030600.77129447
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76957633
98Hematopoietic cell lineage_Homo sapiens_hsa046400.75810704
99Endometrial cancer_Homo sapiens_hsa052130.74638539
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73722883
101Starch and sucrose metabolism_Homo sapiens_hsa005000.73233607
102Huntingtons disease_Homo sapiens_hsa050160.73207913
103Salivary secretion_Homo sapiens_hsa049700.72998583
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72700983
105HTLV-I infection_Homo sapiens_hsa051660.72077440
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71649804
107Hippo signaling pathway_Homo sapiens_hsa043900.71096954
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69913909
109Phagosome_Homo sapiens_hsa041450.68987858
110Toxoplasmosis_Homo sapiens_hsa051450.68585892
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66807433
112Arginine and proline metabolism_Homo sapiens_hsa003300.66093668
113Adherens junction_Homo sapiens_hsa045200.65742934
114Non-small cell lung cancer_Homo sapiens_hsa052230.65568616
115Thyroid cancer_Homo sapiens_hsa052160.65507934
116Inositol phosphate metabolism_Homo sapiens_hsa005620.65230740
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64006174
118Purine metabolism_Homo sapiens_hsa002300.63379043
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61038750
120Cholinergic synapse_Homo sapiens_hsa047250.60928165
121Ras signaling pathway_Homo sapiens_hsa040140.58272515
122mTOR signaling pathway_Homo sapiens_hsa041500.58104493
123Prostate cancer_Homo sapiens_hsa052150.57175910
124Bile secretion_Homo sapiens_hsa049760.57121594
125Apoptosis_Homo sapiens_hsa042100.57075715
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56402861
127Calcium signaling pathway_Homo sapiens_hsa040200.55686087
128Amphetamine addiction_Homo sapiens_hsa050310.54050557
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54004487
130cAMP signaling pathway_Homo sapiens_hsa040240.53316195
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51643134
132Focal adhesion_Homo sapiens_hsa045100.50872932
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50238111
134Arachidonic acid metabolism_Homo sapiens_hsa005900.49878160
135Leishmaniasis_Homo sapiens_hsa051400.49335519
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.48586031
137Olfactory transduction_Homo sapiens_hsa047400.48434345
138Pyrimidine metabolism_Homo sapiens_hsa002400.48388324
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47429587
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46874454
141Steroid biosynthesis_Homo sapiens_hsa001000.45793600
142Taste transduction_Homo sapiens_hsa047420.44672278
143Lysine degradation_Homo sapiens_hsa003100.44642660
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44092027
145Pancreatic secretion_Homo sapiens_hsa049720.43937457
146Retinol metabolism_Homo sapiens_hsa008300.43857699
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43781540
148Notch signaling pathway_Homo sapiens_hsa043300.43415414
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.43354847
150Nitrogen metabolism_Homo sapiens_hsa009100.42908192
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42223777
152Epstein-Barr virus infection_Homo sapiens_hsa051690.42025961
153Chemical carcinogenesis_Homo sapiens_hsa052040.40564984
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.39864349
155Glioma_Homo sapiens_hsa052140.38739084
156Basal cell carcinoma_Homo sapiens_hsa052170.38024021
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37590362
158B cell receptor signaling pathway_Homo sapiens_hsa046620.35985141
159SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35548923
160Amoebiasis_Homo sapiens_hsa051460.35514420
161Protein digestion and absorption_Homo sapiens_hsa049740.35210622
162Pathways in cancer_Homo sapiens_hsa052000.35000144
163Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34774844
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.33191736
165Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33023518
166Estrogen signaling pathway_Homo sapiens_hsa049150.32696707
167Melanogenesis_Homo sapiens_hsa049160.32385074
168Serotonergic synapse_Homo sapiens_hsa047260.31279928
169TNF signaling pathway_Homo sapiens_hsa046680.31175588
170Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30647499
171Cysteine and methionine metabolism_Homo sapiens_hsa002700.29474406
172Non-homologous end-joining_Homo sapiens_hsa034500.28940752
173Alcoholism_Homo sapiens_hsa050340.27389304
174NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27319056
175Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26486949
176Alzheimers disease_Homo sapiens_hsa050100.25897619
177Renin secretion_Homo sapiens_hsa049240.25257053

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