GNRHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)9.95634106
2cellular response to antibiotic (GO:0071236)9.73480571
3progesterone metabolic process (GO:0042448)9.67663003
4cellular response to gonadotropin stimulus (GO:0071371)9.58635916
5glucocorticoid metabolic process (GO:0008211)9.29213155
6detection of other organism (GO:0098543)9.04220180
7response to insecticide (GO:0017085)8.48465776
8thyroid hormone generation (GO:0006590)8.43670861
9mating behavior (GO:0007617)8.37982664
10C21-steroid hormone metabolic process (GO:0008207)7.90078533
11regulation of secondary heart field cardioblast proliferation (GO:0003266)7.79081873
12regulation of cardioblast proliferation (GO:0003264)7.79081873
13thyroid gland development (GO:0030878)7.76136180
14receptor guanylyl cyclase signaling pathway (GO:0007168)7.66045141
15cellular response to toxic substance (GO:0097237)7.40011849
16Leydig cell differentiation (GO:0033327)7.00580787
17mitotic chromosome condensation (GO:0007076)6.84739010
18thyroid hormone metabolic process (GO:0042403)6.74081169
19benzene-containing compound metabolic process (GO:0042537)6.72390715
20response to gonadotropin (GO:0034698)6.57969880
21hormone biosynthetic process (GO:0042446)6.37586117
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.29948535
23regulation of natural killer cell differentiation (GO:0032823)6.17174092
24cellular response to cadmium ion (GO:0071276)5.90020330
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.82184271
26sister chromatid segregation (GO:0000819)5.77658815
27positive regulation of male gonad development (GO:2000020)5.59033673
28positive regulation of hormone biosynthetic process (GO:0046886)5.54382996
29negative regulation of organ growth (GO:0046621)5.29856339
30regulation of DNA endoreduplication (GO:0032875)5.10009882
31toxin metabolic process (GO:0009404)5.07997385
32cGMP biosynthetic process (GO:0006182)5.06519768
33cellular response to interferon-alpha (GO:0035457)4.99241206
34cellular response to growth hormone stimulus (GO:0071378)4.99150052
35response to phenylpropanoid (GO:0080184)4.96525381
36ketone biosynthetic process (GO:0042181)4.90433149
37mitotic sister chromatid segregation (GO:0000070)4.85097146
38androgen metabolic process (GO:0008209)4.83235432
39metanephric mesenchyme development (GO:0072075)4.76059584
40regulation of male gonad development (GO:2000018)4.74676493
41negative regulation of histone methylation (GO:0031061)4.71010118
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.61273422
43ganglion development (GO:0061548)4.58679575
44response to methylmercury (GO:0051597)4.47507947
45attachment of spindle microtubules to kinetochore (GO:0008608)4.47423201
46estrogen metabolic process (GO:0008210)4.46722470
47cellular response to epinephrine stimulus (GO:0071872)4.44693288
48DNA unwinding involved in DNA replication (GO:0006268)4.41151772
49detection of external biotic stimulus (GO:0098581)4.37857924
50vitamin D metabolic process (GO:0042359)4.24694924
51positive regulation of chemokine secretion (GO:0090197)4.24175421
52sulfation (GO:0051923)4.24120625
53chromosome condensation (GO:0030261)4.22448206
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.20855587
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.20855587
56kidney mesenchyme development (GO:0072074)4.13597656
57myoblast migration (GO:0051451)4.10460718
58pharyngeal system development (GO:0060037)4.10023670
59regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.08041337
60response to corticosterone (GO:0051412)4.06990174
61negative regulation of macrophage differentiation (GO:0045650)4.04411637
62sister chromatid cohesion (GO:0007062)4.02737244
63low-density lipoprotein particle clearance (GO:0034383)4.00735205
64protein localization to kinetochore (GO:0034501)3.98465385
65parturition (GO:0007567)3.97474088
66translesion synthesis (GO:0019985)3.96692704
67positive regulation of hormone metabolic process (GO:0032352)3.96538262
68intracellular lipid transport (GO:0032365)3.92289027
69response to vitamin E (GO:0033197)3.91540359
70regulation of gonadotropin secretion (GO:0032276)3.90933344
71induction of positive chemotaxis (GO:0050930)3.90377426
72response to lead ion (GO:0010288)3.88544899
73necroptotic process (GO:0070266)3.86746170
74proline transport (GO:0015824)3.85836065
75positive regulation of macrophage activation (GO:0043032)3.85153908
76iron ion import (GO:0097286)3.84680991
77reproductive behavior (GO:0019098)3.83063348
78phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.81502700
79peptide hormone processing (GO:0016486)3.77831602
80kinetochore organization (GO:0051383)3.75761492
81microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.74760351
82multi-organism reproductive behavior (GO:0044705)3.74000361
83positive regulation of cGMP biosynthetic process (GO:0030828)3.71911792
84establishment of mitotic spindle localization (GO:0040001)3.70968484
85steroid biosynthetic process (GO:0006694)3.68237840
86nephron tubule formation (GO:0072079)3.66812667
87retina vasculature morphogenesis in camera-type eye (GO:0061299)3.65952989
88regulation of histone H3-K9 methylation (GO:0051570)3.65746419
89phosphatidylinositol acyl-chain remodeling (GO:0036149)3.65322627
90spindle assembly involved in mitosis (GO:0090307)3.65209860
91regulation of cellular extravasation (GO:0002691)3.61786162
92regulation of chemokine secretion (GO:0090196)3.61650444
93response to epinephrine (GO:0071871)3.57308748
94anatomical structure arrangement (GO:0048532)3.57154793
95detection of biotic stimulus (GO:0009595)3.51494382
96protein localization to chromosome, centromeric region (GO:0071459)3.47171477
97regulation of cGMP biosynthetic process (GO:0030826)3.45433485
98ovulation (GO:0030728)3.44839447
99establishment of nucleus localization (GO:0040023)3.44393196
100regulation of centriole replication (GO:0046599)3.43194253
101response to leptin (GO:0044321)3.40828020
102chromatin remodeling at centromere (GO:0031055)3.38985423
103dosage compensation (GO:0007549)3.37686031
104adrenal gland development (GO:0030325)3.37308674
105DNA packaging (GO:0006323)3.36186941
106cellular ketone metabolic process (GO:0042180)3.35884599
107cytokine metabolic process (GO:0042107)3.35868970
108chromosome segregation (GO:0007059)3.35451041
109DNA topological change (GO:0006265)3.34692349
110sterol metabolic process (GO:0016125)3.33607482
111alanine transport (GO:0032328)3.32655445
112CENP-A containing nucleosome assembly (GO:0034080)3.31635506
113sex differentiation (GO:0007548)3.30167731
114cGMP metabolic process (GO:0046068)3.28871495
115negative regulation of smooth muscle cell differentiation (GO:0051151)3.27353655
116positive regulation of cGMP metabolic process (GO:0030825)3.24144807
117regulation of triglyceride biosynthetic process (GO:0010866)3.23855129
118regulation of female gonad development (GO:2000194)3.22248270
119phosphatidylserine acyl-chain remodeling (GO:0036150)3.20014589
120response to mineralocorticoid (GO:0051385)3.19330473
121macroautophagy (GO:0016236)3.19303811
122positive regulation of triglyceride biosynthetic process (GO:0010867)3.17365390
123positive regulation of steroid biosynthetic process (GO:0010893)3.16051968
124positive regulation of dendritic spine morphogenesis (GO:0061003)3.16021438
125negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.13555350
126postreplication repair (GO:0006301)3.12786672
127cranial nerve structural organization (GO:0021604)3.12311205
128SMAD protein complex assembly (GO:0007183)3.12281747
129eosinophil chemotaxis (GO:0048245)3.11080952
130DNA replication-independent nucleosome assembly (GO:0006336)3.09469924
131DNA replication-independent nucleosome organization (GO:0034724)3.09469924
132regulation of steroid hormone biosynthetic process (GO:0090030)3.08613421
133axon extension involved in axon guidance (GO:0048846)3.07984803
134neuron projection extension involved in neuron projection guidance (GO:1902284)3.07984803
135positive regulation of bone resorption (GO:0045780)3.06716791
136positive regulation of bone remodeling (GO:0046852)3.06716791
137cellular response to dexamethasone stimulus (GO:0071549)3.05370457
138establishment of protein localization to Golgi (GO:0072600)3.00647919
139mitotic recombination (GO:0006312)2.90419219
140establishment of spindle localization (GO:0051293)2.89054845
141sterol catabolic process (GO:0016127)2.86133937
142cholesterol catabolic process (GO:0006707)2.86133937
143regulation of cGMP metabolic process (GO:0030823)2.84055024
144response to cadmium ion (GO:0046686)2.83849771
145steroid catabolic process (GO:0006706)2.83692512
146regulation of heart morphogenesis (GO:2000826)2.82665813
147response to dexamethasone (GO:0071548)2.82062635
148cholesterol transport (GO:0030301)2.80719057
149sterol transport (GO:0015918)2.80719057
150negative regulation of axon extension involved in axon guidance (GO:0048843)2.80405764
151cranial nerve morphogenesis (GO:0021602)2.78991193
152cilium or flagellum-dependent cell motility (GO:0001539)2.78263778
153response to lipoprotein particle (GO:0055094)2.77918146
154generation of neurons (GO:0048699)2.76938677
155tachykinin receptor signaling pathway (GO:0007217)2.75451423
156cholesterol biosynthetic process (GO:0006695)2.75180538
157negative regulation of fatty acid biosynthetic process (GO:0045717)2.74899938
158negative regulation of cell cycle G2/M phase transition (GO:1902750)2.74806520
159maintenance of protein location in nucleus (GO:0051457)2.73533450
160meiotic chromosome segregation (GO:0045132)2.72004924
161cholesterol metabolic process (GO:0008203)2.71785681
162cellular response to sterol (GO:0036315)2.71731401
163cellular hormone metabolic process (GO:0034754)2.71589213
164negative regulation of heart rate (GO:0010459)2.71165915
165nucleus localization (GO:0051647)2.71137526
166embryonic process involved in female pregnancy (GO:0060136)2.70722685
167response to growth hormone (GO:0060416)2.69439146
168cholesterol efflux (GO:0033344)2.68615610
169peptidyl-lysine dimethylation (GO:0018027)2.68569299
170protein targeting to Golgi (GO:0000042)2.67634369
171epithelial cell maturation (GO:0002070)2.66998822
172neuron cell-cell adhesion (GO:0007158)2.66233031
173retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64849923
174positive regulation of action potential (GO:0045760)2.64204541
175regulation of interleukin-5 production (GO:0032674)2.63510473
176positive regulation of nitric-oxide synthase activity (GO:0051000)2.62096214
177axonal fasciculation (GO:0007413)2.61478530
178hemoglobin metabolic process (GO:0020027)2.55800586
179positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53398413
180sterol biosynthetic process (GO:0016126)2.50271533
181regulation of steroid biosynthetic process (GO:0050810)2.48246420
182ribonucleoside bisphosphate metabolic process (GO:0033875)2.46573847
183nucleoside bisphosphate metabolic process (GO:0033865)2.46573847
184purine nucleoside bisphosphate metabolic process (GO:0034032)2.46573847
185cellular response to cholesterol (GO:0071397)2.46098821
186isoprenoid biosynthetic process (GO:0008299)2.44041295
187response to antibiotic (GO:0046677)2.41002701
188cellular response to follicle-stimulating hormone stimulus (GO:0071372)15.8349744
189endocrine hormone secretion (GO:0060986)13.0125006
190response to follicle-stimulating hormone (GO:0032354)12.3172268
191C21-steroid hormone biosynthetic process (GO:0006700)11.6409028
192glucocorticoid biosynthetic process (GO:0006704)11.0022999
193estrogen biosynthetic process (GO:0006703)10.7398207
194detection of bacterium (GO:0016045)10.5290821
195androgen biosynthetic process (GO:0006702)10.2341668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.70158674
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.36513891
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.35776521
4ZNF263_19887448_ChIP-Seq_K562_Human3.31933903
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.27425730
6IGF1R_20145208_ChIP-Seq_DFB_Human3.05810362
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97446116
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72169785
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68512324
10VDR_22108803_ChIP-Seq_LS180_Human2.51186038
11EZH2_22144423_ChIP-Seq_EOC_Human2.43512566
12FUS_26573619_Chip-Seq_HEK293_Human2.42476565
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.32232326
14* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.26997781
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.24517030
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.20362487
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.13409833
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06569725
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06321851
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05131798
21AR_21909140_ChIP-Seq_LNCAP_Human2.02192038
22E2F7_22180533_ChIP-Seq_HELA_Human10.3999744
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99587889
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95692561
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.94055300
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87188613
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.80798723
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75831357
29BCAT_22108803_ChIP-Seq_LS180_Human1.72315150
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71702662
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71543320
32* EWS_26573619_Chip-Seq_HEK293_Human1.67815864
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66815352
34TP53_16413492_ChIP-PET_HCT116_Human1.66589008
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60282378
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59105779
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.57485054
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56581779
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.55642687
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55594397
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.55065430
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.54188596
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53296021
44SMAD1_18555785_Chip-Seq_ESCs_Mouse1.52427513
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52125387
46P300_18555785_Chip-Seq_ESCs_Mouse1.50888662
47CTCF_18555785_Chip-Seq_ESCs_Mouse1.49886038
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49840914
49AR_25329375_ChIP-Seq_VCAP_Human1.47131626
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.45470205
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45367199
52CLOCK_20551151_ChIP-Seq_293T_Human1.44006296
53TCF4_23295773_ChIP-Seq_U87_Human1.43612283
54TAF15_26573619_Chip-Seq_HEK293_Human1.43573906
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43455187
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.42362049
57GBX2_23144817_ChIP-Seq_PC3_Human1.42201693
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40565140
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40397552
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.39953399
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.39424184
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38409701
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38367090
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36419753
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35690777
66TCF4_22108803_ChIP-Seq_LS180_Human1.34596834
67CBP_20019798_ChIP-Seq_JUKART_Human1.33975270
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33975270
69ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33383688
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.32628468
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.31614276
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.30352766
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30337760
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30337760
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.29705651
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27633625
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26929591
78ZFX_18555785_Chip-Seq_ESCs_Mouse1.26690949
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25193791
80ELK1_19687146_ChIP-ChIP_HELA_Human1.23863696
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.22252324
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21292918
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20941876
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20422261
85IRF1_19129219_ChIP-ChIP_H3396_Human1.19749136
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19061607
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18781305
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18678705
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18678705
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17257394
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.16915993
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15585908
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15036574
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14529945
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.12131761
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11454473
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11314054
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10770724
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10650190
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.10356732
101PU1_27457419_Chip-Seq_LIVER_Mouse1.10322074
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09543423
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08802149
104P53_22387025_ChIP-Seq_ESCs_Mouse1.08697034
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08027089
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08014813
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.07950487
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05691377
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.05432288
110AHR_22903824_ChIP-Seq_MCF-7_Human1.04025409
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02409546
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01510183
113P300_19829295_ChIP-Seq_ESCs_Human1.01412300
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00090046
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99682163
116TP53_18474530_ChIP-ChIP_U2OS_Human0.99570168
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99497915
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.97212255
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96859678
120AR_21572438_ChIP-Seq_LNCaP_Human0.96515111
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95511509
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94765724
123CDX2_22108803_ChIP-Seq_LS180_Human0.94105019
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94047184
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93614400
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93476605
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93074844
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92550816
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91809474
130SMAD4_21799915_ChIP-Seq_A2780_Human0.91585832
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90080288
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.87296834
133STAT3_23295773_ChIP-Seq_U87_Human0.85075029
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83931317
135* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83458221
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81264409
137RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80795221
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79717434
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79713379
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.79094408
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.78439718
142CBP_21632823_ChIP-Seq_H3396_Human0.77163248
143RNF2_27304074_Chip-Seq_NSC_Mouse0.75699333
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75363524
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74724612
146ER_23166858_ChIP-Seq_MCF-7_Human0.74480765
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.74087550
148RUNX2_22187159_ChIP-Seq_PCA_Human0.73463488
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.73347784
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72291815
151NANOG_16518401_ChIP-PET_MESCs_Mouse0.71390905
152WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70390899
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.70380301
154ZNF274_21170338_ChIP-Seq_K562_Hela0.70206380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology8.64850081
2MP0002909_abnormal_adrenal_gland5.44429206
3MP0002009_preneoplasia4.66489103
4MP0000681_abnormal_thyroid_gland4.51310488
5MP0010368_abnormal_lymphatic_system4.18864846
6MP0003011_delayed_dark_adaptation3.87985000
7MP0008995_early_reproductive_senescence3.77490170
8MP0000631_abnormal_neuroendocrine_gland3.75440108
9MP0003122_maternal_imprinting3.59339627
10MP0001346_abnormal_lacrimal_gland3.52842689
11MP0003941_abnormal_skin_development3.16351918
12MP0010030_abnormal_orbit_morphology2.96844774
13MP0009840_abnormal_foam_cell2.65778777
14MP0009780_abnormal_chondrocyte_physiolo2.57676827
15MP0001502_abnormal_circadian_rhythm2.40121014
16MP0009379_abnormal_foot_pigmentation2.37617284
17MP0005379_endocrine/exocrine_gland_phen2.28113025
18MP0003787_abnormal_imprinting2.27058292
19MP0010307_abnormal_tumor_latency2.17531796
20MP0010386_abnormal_urinary_bladder2.15323180
21MP0008875_abnormal_xenobiotic_pharmacok2.10829908
22* MP0005187_abnormal_penis_morphology2.09209591
23MP0005253_abnormal_eye_physiology2.05506338
24MP0003690_abnormal_glial_cell2.03395352
25MP0003300_gastrointestinal_ulcer1.95836904
26MP0001188_hyperpigmentation1.87997299
27MP0010094_abnormal_chromosome_stability1.86497736
28MP0008789_abnormal_olfactory_epithelium1.85700837
29MP0003890_abnormal_embryonic-extraembry1.85542554
30MP0010234_abnormal_vibrissa_follicle1.83087253
31MP0001984_abnormal_olfaction1.80455504
32MP0001299_abnormal_eye_distance/1.76703132
33MP0008007_abnormal_cellular_replicative1.75391987
34MP0003705_abnormal_hypodermis_morpholog1.75384555
35MP0002837_dystrophic_cardiac_calcinosis1.75318392
36MP0002638_abnormal_pupillary_reflex1.74857359
37MP0002166_altered_tumor_susceptibility1.69712828
38MP0001485_abnormal_pinna_reflex1.62813124
39MP0005551_abnormal_eye_electrophysiolog1.62782036
40MP0001765_abnormal_ion_homeostasis1.61408161
41MP0005171_absent_coat_pigmentation1.60245891
42MP0003121_genomic_imprinting1.59406548
43MP0003567_abnormal_fetal_cardiomyocyte1.58905354
44MP0005646_abnormal_pituitary_gland1.58613509
45MP0000569_abnormal_digit_pigmentation1.58608595
46MP0003950_abnormal_plasma_membrane1.51742222
47MP0002877_abnormal_melanocyte_morpholog1.46808840
48* MP0000647_abnormal_sebaceous_gland1.46671340
49MP0004043_abnormal_pH_regulation1.46332336
50MP0005248_abnormal_Harderian_gland1.40225436
51MP0003123_paternal_imprinting1.38886268
52MP0003091_abnormal_cell_migration1.37494397
53MP0001529_abnormal_vocalization1.36827951
54MP0000427_abnormal_hair_cycle1.32222587
55MP0004133_heterotaxia1.26211179
56MP0003786_premature_aging1.22772583
57MP0002139_abnormal_hepatobiliary_system1.22599493
58MP0010352_gastrointestinal_tract_polyps1.22580776
59MP0002006_tumorigenesis1.22294622
60MP0005083_abnormal_biliary_tract1.22261799
61MP0001727_abnormal_embryo_implantation1.21229660
62MP0002938_white_spotting1.20842494
63MP0005636_abnormal_mineral_homeostasis1.20463879
64MP0009703_decreased_birth_body1.19764070
65MP0004270_analgesia1.19588767
66MP0004215_abnormal_myocardial_fiber1.17888580
67MP0000534_abnormal_ureter_morphology1.17676822
68MP0003632_abnormal_nervous_system1.17030554
69MP0000015_abnormal_ear_pigmentation1.15607635
70MP0001661_extended_life_span1.15168633
71MP0004147_increased_porphyrin_level1.14806463
72MP0005389_reproductive_system_phenotype1.13120063
73MP0000372_irregular_coat_pigmentation1.10796578
74MP0005220_abnormal_exocrine_pancreas1.09467026
75MP0002736_abnormal_nociception_after1.09344910
76MP0002751_abnormal_autonomic_nervous1.06900750
77MP0003938_abnormal_ear_development1.06807951
78MP0002090_abnormal_vision1.06235871
79MP0009046_muscle_twitch1.05358215
80MP0008569_lethality_at_weaning1.05251773
81MP0004924_abnormal_behavior1.05113139
82MP0005386_behavior/neurological_phenoty1.05113139
83MP0003136_yellow_coat_color1.04651340
84MP0005391_vision/eye_phenotype1.02182172
85MP0002557_abnormal_social/conspecific_i1.02028388
86MP0002184_abnormal_innervation1.00484024
87MP0005666_abnormal_adipose_tissue0.98735065
88MP0003111_abnormal_nucleus_morphology0.98345155
89MP0001968_abnormal_touch/_nociception0.97736651
90MP0005645_abnormal_hypothalamus_physiol0.97418915
91MP0002234_abnormal_pharynx_morphology0.97105691
92MP0009745_abnormal_behavioral_response0.96569754
93MP0004142_abnormal_muscle_tone0.96260210
94* MP0003953_abnormal_hormone_level0.95354755
95MP0010678_abnormal_skin_adnexa0.95136867
96MP0003942_abnormal_urinary_system0.95134048
97MP0003329_amyloid_beta_deposits0.94309786
98MP0006072_abnormal_retinal_apoptosis0.93907961
99MP0002735_abnormal_chemical_nociception0.93852352
100MP0000013_abnormal_adipose_tissue0.92966382
101MP0002177_abnormal_outer_ear0.92718192
102MP0003045_fibrosis0.92479288
103MP0002277_abnormal_respiratory_mucosa0.91880231
104MP0000467_abnormal_esophagus_morphology0.91471027
105MP0000778_abnormal_nervous_system0.90704412
106MP0005647_abnormal_sex_gland0.89916766
107MP0003880_abnormal_central_pattern0.89536124
108MP0001340_abnormal_eyelid_morphology0.89521144
109MP0000350_abnormal_cell_proliferation0.87722238
110MP0004782_abnormal_surfactant_physiolog0.87404039
111MP0004019_abnormal_vitamin_homeostasis0.87131755
112MP0003656_abnormal_erythrocyte_physiolo0.86955858
113MP0001879_abnormal_lymphatic_vessel0.85134977
114MP0006035_abnormal_mitochondrial_morpho0.82569915
115MP0003984_embryonic_growth_retardation0.81888627
116MP0003935_abnormal_craniofacial_develop0.81276407
117MP0004197_abnormal_fetal_growth/weight/0.80118713
118MP0003718_maternal_effect0.79583961
119MP0002088_abnormal_embryonic_growth/wei0.79144276
120MP0003077_abnormal_cell_cycle0.79075145
121* MP0001929_abnormal_gametogenesis0.78900542
122* MP0001119_abnormal_female_reproductive0.77038197
123MP0004134_abnormal_chest_morphology0.76501317
124MP0008961_abnormal_basal_metabolism0.76333929
125MP0008877_abnormal_DNA_methylation0.76002611
126MP0005380_embryogenesis_phenotype0.75194459
127MP0001672_abnormal_embryogenesis/_devel0.75194459
128MP0005076_abnormal_cell_differentiation0.74710078
129MP0000371_diluted_coat_color0.74400316
130MP0009672_abnormal_birth_weight0.72952172
131MP0010329_abnormal_lipoprotein_level0.72911534
132MP0005167_abnormal_blood-brain_barrier0.71635542
133* MP0002210_abnormal_sex_determination0.71568208
134MP0002084_abnormal_developmental_patter0.70942513
135MP0002064_seizures0.70330783
136MP0003937_abnormal_limbs/digits/tail_de0.69301593
137MP0008057_abnormal_DNA_replication0.68855440
138MP0001919_abnormal_reproductive_system0.68776903
139MP0003635_abnormal_synaptic_transmissio0.68218036
140MP0004185_abnormal_adipocyte_glucose0.67204973
141MP0002971_abnormal_brown_adipose0.66074801
142MP0000639_abnormal_adrenal_gland0.66057633
143MP0003453_abnormal_keratinocyte_physiol0.65932265
144MP0002063_abnormal_learning/memory/cond0.65744361
145MP0004742_abnormal_vestibular_system0.65049704
146MP0001963_abnormal_hearing_physiology0.64956728
147MP0005375_adipose_tissue_phenotype0.64918886
148MP0004130_abnormal_muscle_cell0.64491191
149MP0001486_abnormal_startle_reflex0.64402470
150MP0005670_abnormal_white_adipose0.63980068
151MP0009115_abnormal_fat_cell0.63430065
152* MP0000653_abnormal_sex_gland0.63341899
153MP0009278_abnormal_bone_marrow0.62440351
154MP0001970_abnormal_pain_threshold0.62370359
155MP0000230_abnormal_systemic_arterial0.61622139
156MP0004859_abnormal_synaptic_plasticity0.61512272
157MP0000751_myopathy0.61152987
158MP0001873_stomach_inflammation0.60829380
159* MP0001145_abnormal_male_reproductive0.60783245
160MP0002160_abnormal_reproductive_system0.60287794
161MP0001697_abnormal_embryo_size0.60257217
162MP0004484_altered_response_of0.58830309
163MP0004085_abnormal_heartbeat0.58747413
164MP0009250_abnormal_appendicular_skeleto0.57764070
165MP0003283_abnormal_digestive_organ0.57750801
166MP0002734_abnormal_mechanical_nocicepti0.57525691
167MP0001756_abnormal_urination0.56851416
168MP0003943_abnormal_hepatobiliary_system0.56310617
169MP0003631_nervous_system_phenotype0.55927743

Predicted human phenotypes

RankGene SetZ-score
1Renal salt wasting (HP:0000127)9.85513978
2Lip pit (HP:0100267)7.25484887
3Abnormal sex determination (HP:0012244)6.61975571
4Sex reversal (HP:0012245)6.61975571
5Volvulus (HP:0002580)6.48323963
6Macroorchidism (HP:0000053)5.66314220
7Hyperaldosteronism (HP:0000859)5.56990806
8Hypochromic microcytic anemia (HP:0004840)4.72532767
9Conjunctival telangiectasia (HP:0000524)4.58235929
10Decreased circulating renin level (HP:0003351)4.58087503
11Ankyloglossia (HP:0010296)4.11988181
12Hypoplasia of the uterus (HP:0000013)4.08254015
13Subcapsular cataract (HP:0000523)4.06266166
14Impulsivity (HP:0100710)4.03727859
15Hypokalemic alkalosis (HP:0001949)3.90697812
16Papilledema (HP:0001085)3.78840269
17Heterotopia (HP:0002282)3.75897131
18Increased nuchal translucency (HP:0010880)3.67629394
19Male pseudohermaphroditism (HP:0000037)3.64912411
20Truncal obesity (HP:0001956)3.63410268
21Abnormality of the vasculature of the conjunctiva (HP:0008054)3.51316704
22Obsessive-compulsive behavior (HP:0000722)3.46926386
23Bifid tongue (HP:0010297)3.43613106
24Sensory axonal neuropathy (HP:0003390)3.31764142
25Clitoromegaly (HP:0000057)3.31159947
26Inappropriate behavior (HP:0000719)3.27307730
27Absent eyebrow (HP:0002223)3.26834187
28Lymphangioma (HP:0100764)3.25844469
29Increased number of teeth (HP:0011069)3.24721958
30Preauricular pit (HP:0004467)3.18672411
31Periauricular skin pits (HP:0100277)3.18672411
32Hemorrhage of the eye (HP:0011885)3.11308221
33Aplasia/hypoplasia of the uterus (HP:0008684)3.06343885
34Testicular neoplasm (HP:0010788)3.04540348
35Abnormality of oral frenula (HP:0000190)3.02001909
36Pigmentary retinal degeneration (HP:0001146)3.01650764
37Azoospermia (HP:0000027)2.97128732
38Gonadal dysgenesis (HP:0000133)2.91740729
39Premature ovarian failure (HP:0008209)2.91502254
40Abnormality of chromosome stability (HP:0003220)2.87076062
41Absent speech (HP:0001344)2.85713838
42Abnormality of the renal collecting system (HP:0004742)2.85221151
43Pancreatic cysts (HP:0001737)2.83651573
44Enlarged penis (HP:0000040)2.83389639
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.81078521
46Vaginal atresia (HP:0000148)2.79480695
47Abnormality of chromosome segregation (HP:0002916)2.77932443
48Hyperthyroidism (HP:0000836)2.76606041
49Abnormal lung lobation (HP:0002101)2.74323364
50Tapered finger (HP:0001182)2.73667256
51Genital tract atresia (HP:0001827)2.73146217
52Bicornuate uterus (HP:0000813)2.70950034
53Midline defect of the nose (HP:0004122)2.70930327
54Rectal prolapse (HP:0002035)2.70599581
55Cupped ear (HP:0000378)2.69829040
56Astrocytoma (HP:0009592)2.69011688
57Abnormality of the astrocytes (HP:0100707)2.69011688
58Secondary amenorrhea (HP:0000869)2.68051328
59Adrenal hypoplasia (HP:0000835)2.67026334
60Agitation (HP:0000713)2.66732210
61X-linked recessive inheritance (HP:0001419)2.66057621
62Protruding tongue (HP:0010808)2.58437526
63Colon cancer (HP:0003003)2.55606742
64Hypercortisolism (HP:0001578)2.54594880
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54451712
66Skin pits (HP:0100276)2.52933165
67Truncal ataxia (HP:0002078)2.51455032
68Morphological abnormality of the middle ear (HP:0008609)2.50965656
69Pancreatic fibrosis (HP:0100732)2.50885093
70Adrenal overactivity (HP:0002717)2.49938650
71Hypopigmentation of the fundus (HP:0007894)2.47592835
72Absent frontal sinuses (HP:0002688)2.46366748
73Coronal craniosynostosis (HP:0004440)2.45386256
74Abnormality of the 4th metacarpal (HP:0010012)2.44118653
75Fibular aplasia (HP:0002990)2.41336440
76True hermaphroditism (HP:0010459)2.39044725
77Menstrual irregularities (HP:0000858)2.36840630
78Disinhibition (HP:0000734)2.35888855
79Abnormality of the pubic bones (HP:0003172)2.34733774
80Abnormality of the phalanges of the 2nd finger (HP:0009541)2.34701929
81Breech presentation (HP:0001623)2.33259249
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.30760950
83Sacral dimple (HP:0000960)2.30204952
84Long clavicles (HP:0000890)2.29694986
85Female pseudohermaphroditism (HP:0010458)2.29635564
86Bilateral microphthalmos (HP:0007633)2.29253899
87Atresia of the external auditory canal (HP:0000413)2.26465830
88Intellectual disability, mild (HP:0001256)2.26037637
89Hypophosphatemic rickets (HP:0004912)2.24203298
90Action tremor (HP:0002345)2.23754145
91Ependymoma (HP:0002888)2.22139325
92Asplenia (HP:0001746)2.21422117
93Accelerated skeletal maturation (HP:0005616)2.20827729
94Posterior subcapsular cataract (HP:0007787)2.20714740
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.20587833
96Flat face (HP:0012368)2.19785070
97Medial flaring of the eyebrow (HP:0010747)2.19745361
98Absent eyelashes (HP:0000561)2.19190377
99Chromsome breakage (HP:0040012)2.18065894
100Bile duct proliferation (HP:0001408)2.15862560
101Abnormal biliary tract physiology (HP:0012439)2.15862560
102Aplasia/Hypoplasia of the sternum (HP:0006714)2.15774004
103Osteomalacia (HP:0002749)2.14325158
104Hyperpituitarism (HP:0010514)2.13866395
105Short tibia (HP:0005736)2.11446054
106Abnormality of the frontal sinuses (HP:0002687)2.11015854
107Gaze-evoked nystagmus (HP:0000640)2.10251643
108Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10124099
109Impaired social interactions (HP:0000735)2.09770738
110Abnormal social behavior (HP:0012433)2.09770738
111Delayed CNS myelination (HP:0002188)2.08307419
112Abnormal spermatogenesis (HP:0008669)2.07016812
113Renal cortical cysts (HP:0000803)2.04375628
114Short 4th metacarpal (HP:0010044)2.03741147
115Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03741147
116Glioma (HP:0009733)2.03357124
117Tubulointerstitial nephritis (HP:0001970)2.03219977
118Occipital encephalocele (HP:0002085)2.02401385
119Aplasia/Hypoplasia of the spleen (HP:0010451)2.01150908
120Cutaneous finger syndactyly (HP:0010554)2.00467542
121Abnormality of cochlea (HP:0000375)1.99183112
122Scrotal hypoplasia (HP:0000046)1.98546212
123Fair hair (HP:0002286)1.98513337
124Aplasia/Hypoplasia of the fibula (HP:0006492)1.98290534
125* Primary amenorrhea (HP:0000786)1.98121005
126Vertebral clefting (HP:0008428)1.97295341
127Gynecomastia (HP:0000771)1.96221600
128Type II lissencephaly (HP:0007260)1.95918455
129Redundant skin (HP:0001582)1.95474922
130Abnormality of the clitoris (HP:0000056)1.95423386
131Hematochezia (HP:0002573)1.94911015
132Excessive salivation (HP:0003781)1.93318188
133Drooling (HP:0002307)1.93318188
134Aortic aneurysm (HP:0004942)1.92285525
135Polar cataract (HP:0010696)1.91083250
136Congenital primary aphakia (HP:0007707)1.89812181
137Gait imbalance (HP:0002141)1.89761472
138Ovarian neoplasm (HP:0100615)1.89740668
139Hyperventilation (HP:0002883)1.89283038
140Depression (HP:0000716)1.89254215
141Choanal stenosis (HP:0000452)1.89206551
142Optic nerve hypoplasia (HP:0000609)1.88687593
143Myelomeningocele (HP:0002475)1.87856115
144Abnormality of ocular smooth pursuit (HP:0000617)1.87319952
145Large earlobe (HP:0009748)1.87111866
146Abnormality of secondary sexual hair (HP:0009888)1.87034895
147Abnormality of the axillary hair (HP:0100134)1.87034895
148Abnormality of the renal cortex (HP:0011035)1.86848447
149Cafe-au-lait spot (HP:0000957)1.86159359
150Thickened helices (HP:0000391)1.85840244
151Broad-based gait (HP:0002136)1.85709340
152Facial hemangioma (HP:0000329)1.85669960
153Anophthalmia (HP:0000528)1.84982063
154Abnormality of renin-angiotensin system (HP:0000847)1.83897202
155Tented upper lip vermilion (HP:0010804)1.83526828
156Overriding aorta (HP:0002623)1.82668160
157Complete atrioventricular canal defect (HP:0001674)1.82367393
158Attention deficit hyperactivity disorder (HP:0007018)1.82137030
159Hyporeflexia of lower limbs (HP:0002600)1.81862712
160Progressive cerebellar ataxia (HP:0002073)1.81368796
161Aplasia/Hypoplasia of the nipples (HP:0006709)1.81125473
162Termporal pattern (HP:0011008)1.80505314
163Insidious onset (HP:0003587)1.80505314
164Poor eye contact (HP:0000817)1.80472204
165Generalized hypopigmentation of hair (HP:0011358)1.78868483
166Mucosal telangiectasiae (HP:0100579)1.76899674
167* Decreased testicular size (HP:0008734)1.75982247
168Resting tremor (HP:0002322)1.75908603
169Pheochromocytoma (HP:0002666)1.75695553
170Hypoplasia of the maxilla (HP:0000327)1.75634628
171Aqueductal stenosis (HP:0002410)1.75367519
172Macrotia (HP:0000400)1.73837486
173Arteriovenous malformation (HP:0100026)1.73573403
174Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71501787
175Thyroid-stimulating hormone excess (HP:0002925)1.71374351
176Tracheal stenosis (HP:0002777)1.70681918
177Exocrine pancreatic insufficiency (HP:0001738)1.70210080
178Poor coordination (HP:0002370)1.68304726
179Spinal canal stenosis (HP:0003416)1.67507943
180Aplasia/Hypoplasia of the tongue (HP:0010295)1.67500355
181Epidermoid cyst (HP:0200040)1.67063849
182Biliary tract neoplasm (HP:0100574)1.66338149
183Nephronophthisis (HP:0000090)1.65793983
184Pointed chin (HP:0000307)1.65652423
185Abnormality of the renal medulla (HP:0100957)1.64837162
186Absent hair (HP:0002298)1.62861304
187Nephrogenic diabetes insipidus (HP:0009806)1.62191772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.19921169
2MELK4.15193832
3CASK4.04364832
4YES14.02576180
5TRPM73.99309351
6ACVR1B3.76621082
7MAP4K23.63365061
8CDK63.17718976
9CDC73.15813893
10SCYL22.97145456
11MAP3K22.95689864
12CDK122.71516287
13DYRK1B2.64064494
14UHMK12.62391460
15CLK12.50797142
16GRK52.42634751
17FGFR22.32523459
18NEK12.21381776
19MAP2K72.20025828
20EPHA42.19141303
21MAP3K122.15441557
22PINK12.14976119
23BRSK12.04982589
24CSNK1G21.93600219
25BRSK21.85028518
26CDK41.83759674
27BCR1.82575802
28CSNK1G11.78662421
29AURKB1.72165283
30NEK21.71633486
31KSR21.71235539
32CSNK1A1L1.67081632
33ERBB31.64010572
34PNCK1.63540598
35FGFR31.56445565
36CSNK1G31.56338362
37FLT31.56323392
38WNK31.49344436
39BRD41.49213062
40NTRK31.47027487
41CDK31.40109195
42RIPK41.39029902
43INSRR1.38923853
44HIPK21.37901838
45FRK1.35140312
46STK38L1.33879955
47KSR11.33634558
48MAPK131.27086938
49RIPK11.24663817
50MAP3K91.23438086
51ZAK1.22288648
52TAOK31.22071581
53CDC42BPA1.20968245
54TRIM281.20296110
55TRIB31.19078813
56TLK11.17757609
57RET1.17747592
58PKN21.14253396
59SGK21.12087038
60FER1.09473768
61NEK91.07461307
62TNIK1.05098560
63PLK31.03453257
64PRKCE1.02526693
65MAP3K71.01890288
66BMPR1B1.00839987
67GRK10.93905604
68MKNK20.91307058
69STK100.90231940
70SGK2230.87086993
71SGK4940.87086993
72CAMKK20.84508793
73ATR0.83486739
74ATM0.83370222
75CSNK1A10.82891215
76DYRK20.82399300
77MAP2K40.79277800
78STK30.79075835
79CHEK20.77676431
80MINK10.76423252
81FGFR10.75033548
82MAP3K50.72563179
83PLK10.70118744
84SRPK10.68617530
85CDK10.67482208
86CHEK10.65757924
87CCNB10.62650332
88PAK30.60902461
89CDK20.59211921
90CDK80.56843989
91CDK90.56357063
92ERBB20.53822003
93MYLK0.52985895
94WEE10.52640635
95JAK20.50395575
96MAP2K10.50101249
97PKN10.49186553
98DYRK30.48881564
99ERBB40.48842837
100PAK60.48842561
101CSK0.47934963
102MAP3K40.47326848
103RPS6KA40.47055700
104FGFR40.46557371
105PHKG10.46163476
106PHKG20.46163476
107PRKCG0.45919140
108PBK0.45351427
109NLK0.44925937
110CSNK1E0.44732856
111MAPK100.43004067
112TIE10.42493476
113SGK30.42414404
114TGFBR10.42397301
115SGK10.41849262
116STK110.41421473
117OBSCN0.40745703
118DAPK20.40497311
119NTRK20.40398959
120EGFR0.39993104
121PRKDC0.39938909
122CAMK2D0.39700683
123CAMK1G0.39667194
124PRKCI0.39050915
125STK390.38841909
126DYRK1A0.38637097
127PLK20.38165133
128ROCK10.38072706
129CSNK1D0.37693486
130CDK140.37452416
131MAPK140.36739363
132WNK10.36429340
133PRKD20.36397592
134PRKACA0.36225603
135FGR0.35891117
136MST40.35649052
137CDK70.35353786
138PLK40.35058538
139GSK3A0.34896221
140LATS10.34733845
141STK380.34716403
142TESK10.34419863
143PRKD30.34371918
144EIF2AK30.33609855
145CDK190.32735268
146MAPK110.32418166
147LIMK10.32185758
148RPS6KA30.32142069
149CDK50.31592600
150GSK3B0.31443553
151PRKACB0.30927682
152RAF10.29673761
153CAMK2A0.29519333
154PDGFRA0.29193488
155PTK2B0.29098334
156IGF1R0.29072750
157MAP3K80.28474634
158WNK40.26923761
159PDK10.26420412
160MARK10.26419219
161ADRBK10.23614624
162AKT20.23250680
163MAP2K30.23075447
164CAMK1D0.22742503
165TYRO30.21789591

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053205.60232144
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.59724711
3Ovarian steroidogenesis_Homo sapiens_hsa049134.54882978
4Aldosterone synthesis and secretion_Homo sapiens_hsa049254.41934251
5Steroid hormone biosynthesis_Homo sapiens_hsa001404.09532291
6Phototransduction_Homo sapiens_hsa047443.45383573
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.81414194
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74229642
9* GnRH signaling pathway_Homo sapiens_hsa049122.69099853
10Type II diabetes mellitus_Homo sapiens_hsa049302.68601108
11Linoleic acid metabolism_Homo sapiens_hsa005912.50664380
12Selenocompound metabolism_Homo sapiens_hsa004502.35901456
13Non-homologous end-joining_Homo sapiens_hsa034502.18600318
14Sulfur metabolism_Homo sapiens_hsa009202.10587940
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.97416454
16Thyroid hormone synthesis_Homo sapiens_hsa049181.95500587
17Dorso-ventral axis formation_Homo sapiens_hsa043201.90559605
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90090033
19Ether lipid metabolism_Homo sapiens_hsa005651.85020416
20Prolactin signaling pathway_Homo sapiens_hsa049171.82529139
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.80219374
22Cell cycle_Homo sapiens_hsa041101.76767581
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.73369809
24Nitrogen metabolism_Homo sapiens_hsa009101.70271015
25Vitamin B6 metabolism_Homo sapiens_hsa007501.61322857
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60245585
27FoxO signaling pathway_Homo sapiens_hsa040681.58577141
28VEGF signaling pathway_Homo sapiens_hsa043701.55777835
29Chemical carcinogenesis_Homo sapiens_hsa052041.52594183
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51460740
31Nicotine addiction_Homo sapiens_hsa050331.48208673
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47772454
33beta-Alanine metabolism_Homo sapiens_hsa004101.47109013
34Mismatch repair_Homo sapiens_hsa034301.43428871
35Protein export_Homo sapiens_hsa030601.39283470
36Long-term depression_Homo sapiens_hsa047301.38789452
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35597158
38Bile secretion_Homo sapiens_hsa049761.35139767
39DNA replication_Homo sapiens_hsa030301.27553407
40Circadian entrainment_Homo sapiens_hsa047131.26168620
41Vitamin digestion and absorption_Homo sapiens_hsa049771.24020252
42Fatty acid biosynthesis_Homo sapiens_hsa000611.23956551
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22379096
44Histidine metabolism_Homo sapiens_hsa003401.22347828
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19987182
46Serotonergic synapse_Homo sapiens_hsa047261.18515035
47Taste transduction_Homo sapiens_hsa047421.14993424
48Tryptophan metabolism_Homo sapiens_hsa003801.14112163
49AMPK signaling pathway_Homo sapiens_hsa041521.11085537
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10863001
51Oocyte meiosis_Homo sapiens_hsa041141.10592700
52Fatty acid metabolism_Homo sapiens_hsa012121.07163589
53Renin secretion_Homo sapiens_hsa049241.02745546
54Colorectal cancer_Homo sapiens_hsa052101.02311476
55Circadian rhythm_Homo sapiens_hsa047100.97089734
56Insulin signaling pathway_Homo sapiens_hsa049100.95918851
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95815377
58Choline metabolism in cancer_Homo sapiens_hsa052310.95074865
59Glutamatergic synapse_Homo sapiens_hsa047240.93382182
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93119780
61Pyruvate metabolism_Homo sapiens_hsa006200.92337383
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90110748
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89633317
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89536603
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85015926
66Fanconi anemia pathway_Homo sapiens_hsa034600.81832713
67Insulin secretion_Homo sapiens_hsa049110.81347482
68Fat digestion and absorption_Homo sapiens_hsa049750.80936196
69MicroRNAs in cancer_Homo sapiens_hsa052060.80111258
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79075743
71Pancreatic cancer_Homo sapiens_hsa052120.77604805
72p53 signaling pathway_Homo sapiens_hsa041150.77295742
73Adherens junction_Homo sapiens_hsa045200.76981913
74mTOR signaling pathway_Homo sapiens_hsa041500.75724063
75Chronic myeloid leukemia_Homo sapiens_hsa052200.72603330
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71873329
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.71114190
78Lysine degradation_Homo sapiens_hsa003100.70160727
79Butanoate metabolism_Homo sapiens_hsa006500.69385834
80Dopaminergic synapse_Homo sapiens_hsa047280.69197102
81Olfactory transduction_Homo sapiens_hsa047400.69116501
82RNA degradation_Homo sapiens_hsa030180.66540649
83Hepatitis B_Homo sapiens_hsa051610.66484633
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66392559
85ABC transporters_Homo sapiens_hsa020100.65147651
86Fatty acid degradation_Homo sapiens_hsa000710.65091512
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63964164
88Calcium signaling pathway_Homo sapiens_hsa040200.63588542
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61917210
90Retinol metabolism_Homo sapiens_hsa008300.61520252
91Oxytocin signaling pathway_Homo sapiens_hsa049210.60261949
92PPAR signaling pathway_Homo sapiens_hsa033200.59742015
93Long-term potentiation_Homo sapiens_hsa047200.59213830
94Cocaine addiction_Homo sapiens_hsa050300.58865814
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57248689
96Steroid biosynthesis_Homo sapiens_hsa001000.51874493
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51338529
98Peroxisome_Homo sapiens_hsa041460.51321813
99Metabolic pathways_Homo sapiens_hsa011000.51067166
100Prostate cancer_Homo sapiens_hsa052150.50860003
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49918222
102Salivary secretion_Homo sapiens_hsa049700.49564688
103Mineral absorption_Homo sapiens_hsa049780.49275542
104Small cell lung cancer_Homo sapiens_hsa052220.48538097
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48428140
106Collecting duct acid secretion_Homo sapiens_hsa049660.48056309
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47813454
108cAMP signaling pathway_Homo sapiens_hsa040240.47184693
109Renin-angiotensin system_Homo sapiens_hsa046140.46275324
110Cholinergic synapse_Homo sapiens_hsa047250.45588089
111* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43674376
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43645858
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.43422122
114Axon guidance_Homo sapiens_hsa043600.43299040
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42840673
116Propanoate metabolism_Homo sapiens_hsa006400.42798483
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42777432
118MAPK signaling pathway_Homo sapiens_hsa040100.42062888
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41298624
120ErbB signaling pathway_Homo sapiens_hsa040120.40926533
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39594176
122Platelet activation_Homo sapiens_hsa046110.39499739
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39458341
124Regulation of autophagy_Homo sapiens_hsa041400.39182866
125Non-small cell lung cancer_Homo sapiens_hsa052230.38428049
126Glioma_Homo sapiens_hsa052140.36847126
127Morphine addiction_Homo sapiens_hsa050320.36536326
128Sphingolipid metabolism_Homo sapiens_hsa006000.35018889
129HTLV-I infection_Homo sapiens_hsa051660.34574291
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34256334
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33877447
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.33504753
133TGF-beta signaling pathway_Homo sapiens_hsa043500.33212900
134Glycerolipid metabolism_Homo sapiens_hsa005610.33005964
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32794877
136GABAergic synapse_Homo sapiens_hsa047270.32571500
137Ras signaling pathway_Homo sapiens_hsa040140.32401733
138Alcoholism_Homo sapiens_hsa050340.32048128
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30640682
140Inositol phosphate metabolism_Homo sapiens_hsa005620.29585437
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.29520895
142Glucagon signaling pathway_Homo sapiens_hsa049220.29393819
143Chemokine signaling pathway_Homo sapiens_hsa040620.29147328
144Basal transcription factors_Homo sapiens_hsa030220.27905853
145Arginine and proline metabolism_Homo sapiens_hsa003300.27329961
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25202272
147Arachidonic acid metabolism_Homo sapiens_hsa005900.24497207
148Amphetamine addiction_Homo sapiens_hsa050310.24255143
149Endometrial cancer_Homo sapiens_hsa052130.22831320
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22816308
151Insulin resistance_Homo sapiens_hsa049310.22717317
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22594585
153Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22403458
154Wnt signaling pathway_Homo sapiens_hsa043100.22173859
155Hippo signaling pathway_Homo sapiens_hsa043900.22128533
156N-Glycan biosynthesis_Homo sapiens_hsa005100.22123344
157Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21900912

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