GNRHR2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.73400703
2cytidine metabolic process (GO:0046087)8.73400703
3cytidine catabolic process (GO:0006216)8.73400703
4DNA deamination (GO:0045006)8.40273141
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.71950772
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.57775685
7cellular response to interleukin-15 (GO:0071350)5.15934868
8regulation of activation of Janus kinase activity (GO:0010533)4.89181921
9positive regulation of T-helper 1 type immune response (GO:0002827)4.15490669
10positive regulation of T cell chemotaxis (GO:0010820)4.08948887
11regulation of T cell chemotaxis (GO:0010819)4.08948887
12response to interleukin-15 (GO:0070672)4.01226235
13positive regulation of T cell mediated cytotoxicity (GO:0001916)3.81971866
14pyrimidine nucleoside catabolic process (GO:0046135)3.81826257
15positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.80879571
16regulation of lymphocyte chemotaxis (GO:1901623)3.75591046
17regulation of leukocyte mediated cytotoxicity (GO:0001910)3.67718286
18positive regulation of T cell cytokine production (GO:0002726)3.67299873
19mannosylation (GO:0097502)3.66266615
20regulation of T cell mediated cytotoxicity (GO:0001914)3.65942827
21positive regulation of natural killer cell mediated immunity (GO:0002717)3.65459519
22pseudouridine synthesis (GO:0001522)3.65260462
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63796081
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63796081
25positive regulation of defense response to virus by host (GO:0002230)3.61156805
26chaperone mediated protein folding requiring cofactor (GO:0051085)3.54465551
27negative regulation by host of viral transcription (GO:0043922)3.42600598
28negative T cell selection (GO:0043383)3.42590910
29negative regulation of viral genome replication (GO:0045071)3.41701589
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.39684686
31regulation of isotype switching to IgG isotypes (GO:0048302)3.33351051
32positive thymic T cell selection (GO:0045059)3.31243366
33regulation of RIG-I signaling pathway (GO:0039535)3.29849709
34eosinophil chemotaxis (GO:0048245)3.29821834
35regulation of chronic inflammatory response (GO:0002676)3.29514020
36positive regulation of cell killing (GO:0031343)3.24215445
37regulation of natural killer cell mediated immunity (GO:0002715)3.22359233
38regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22359233
39regulation of cell killing (GO:0031341)3.22270031
40positive T cell selection (GO:0043368)3.20144944
41cellular response to nicotine (GO:0071316)3.09763656
42regulation of T-helper 1 type immune response (GO:0002825)3.09638926
43regulation of memory T cell differentiation (GO:0043380)3.06518214
44rRNA catabolic process (GO:0016075)3.05450835
45negative regulation of cell killing (GO:0031342)3.04875897
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04875897
47DNA demethylation (GO:0080111)3.04028136
48negative regulation of T cell apoptotic process (GO:0070233)3.03901189
49interferon-gamma production (GO:0032609)3.01991064
50positive regulation of calcium-mediated signaling (GO:0050850)3.00709363
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00195472
52regulation of mitotic spindle checkpoint (GO:1903504)3.00195472
53protein polyglutamylation (GO:0018095)2.98839306
54positive regulation of gamma-delta T cell activation (GO:0046645)2.98060304
55regulation of defense response to virus by host (GO:0050691)2.97628988
56somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96604331
57isotype switching (GO:0045190)2.96604331
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96604331
59dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.94578287
60eosinophil migration (GO:0072677)2.94509337
61positive regulation of T cell mediated immunity (GO:0002711)2.88050962
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.86767732
63regulation of gamma-delta T cell differentiation (GO:0045586)2.86544606
64modulation by host of symbiont transcription (GO:0052472)2.85231693
65modulation by host of viral transcription (GO:0043921)2.85231693
66negative regulation of telomere maintenance (GO:0032205)2.81228994
67positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79269640
68regulation of viral genome replication (GO:0045069)2.76157291
69negative thymic T cell selection (GO:0045060)2.76153951
70regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.74197795
71macrophage chemotaxis (GO:0048246)2.72007458
72positive regulation of lymphocyte migration (GO:2000403)2.71681794
73negative regulation of lymphocyte apoptotic process (GO:0070229)2.71624534
74lymphocyte apoptotic process (GO:0070227)2.67610111
75B cell mediated immunity (GO:0019724)2.67371529
76modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.63908723
77cytolysis (GO:0019835)2.61280885
78pyrimidine ribonucleoside metabolic process (GO:0046131)2.61173359
79negative regulation of viral transcription (GO:0032897)2.61045190
80ubiquinone biosynthetic process (GO:0006744)2.60948613
81negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59941817
82regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.56147428
83metallo-sulfur cluster assembly (GO:0031163)2.55794202
84iron-sulfur cluster assembly (GO:0016226)2.55794202
85regulation of translational termination (GO:0006449)2.51558896
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46923297
87negative regulation of viral process (GO:0048525)2.44230784
88positive regulation of osteoclast differentiation (GO:0045672)2.44173991
89maturation of 5.8S rRNA (GO:0000460)2.43589038
90positive regulation of lymphocyte mediated immunity (GO:0002708)2.43200340
91negative regulation of B cell activation (GO:0050869)2.42697201
92lymphocyte chemotaxis (GO:0048247)2.42087913
93pyrimidine-containing compound catabolic process (GO:0072529)2.41100679
94regulation of regulatory T cell differentiation (GO:0045589)2.40472450
95positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.38313779
96fucose catabolic process (GO:0019317)2.37073061
97L-fucose metabolic process (GO:0042354)2.37073061
98L-fucose catabolic process (GO:0042355)2.37073061
99regulation of calcium-mediated signaling (GO:0050848)2.36028519
100tRNA modification (GO:0006400)2.35656018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.50138568
2ELF1_17652178_ChIP-ChIP_JURKAT_Human5.02897590
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.43505253
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53561656
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16054352
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14193952
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13642021
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91831235
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.91697130
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.88364947
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84239887
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83972433
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.72497155
14VDR_23849224_ChIP-Seq_CD4+_Human2.64680862
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42915702
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.39934780
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.39033502
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24987022
19FOXP3_21729870_ChIP-Seq_TREG_Human2.00102975
20YY1_21170310_ChIP-Seq_MESCs_Mouse1.96861916
21GATA3_26560356_Chip-Seq_TH2_Human1.94557118
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93619291
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92023136
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84943354
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84086408
26IRF1_19129219_ChIP-ChIP_H3396_Human1.78138916
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74325205
28CIITA_25753668_ChIP-Seq_RAJI_Human1.73824379
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72557113
30MYB_26560356_Chip-Seq_TH2_Human1.68893390
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68020099
32E2F7_22180533_ChIP-Seq_HELA_Human1.67805656
33ZNF274_21170338_ChIP-Seq_K562_Hela1.66545328
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66309669
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64862644
36RUNX_20019798_ChIP-Seq_JUKART_Human1.61541222
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59420522
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58971915
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.50200495
40MYC_18940864_ChIP-ChIP_HL60_Human1.49383202
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47839853
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46108405
43ELK1_19687146_ChIP-ChIP_HELA_Human1.44945129
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.43966742
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38297558
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37708554
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37695324
48GATA1_22025678_ChIP-Seq_K562_Human1.36477826
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32210861
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32114360
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31963142
52GATA3_27048872_Chip-Seq_THYMUS_Human1.31641253
53GABP_19822575_ChIP-Seq_HepG2_Human1.24666083
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23517594
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22282692
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21521234
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18049193
58KDM5A_27292631_Chip-Seq_BREAST_Human1.17809249
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.16390383
60SCL_19346495_ChIP-Seq_HPC-7_Human1.14988725
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13835914
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13474721
63DCP1A_22483619_ChIP-Seq_HELA_Human1.12845916
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10640608
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10125355
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08873688
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08445477
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07225698
69MYB_26560356_Chip-Seq_TH1_Human1.07091153
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06776386
71P300_27268052_Chip-Seq_Bcells_Human1.04009725
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03161200
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02533080
74TP53_22573176_ChIP-Seq_HFKS_Human1.02008260
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.01015805
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01015805
77SPI1_23547873_ChIP-Seq_NB4_Human1.00466605
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99445397
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99182443
80ERA_21632823_ChIP-Seq_H3396_Human0.98933697
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97897034
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96335981
83BCL6_27268052_Chip-Seq_Bcells_Human0.96226289
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95152893
85ZNF263_19887448_ChIP-Seq_K562_Human0.94227051
86AR_20517297_ChIP-Seq_VCAP_Human0.93256870
87STAT1_20625510_ChIP-Seq_HELA_Human0.92297606
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.91578320
89GATA3_26560356_Chip-Seq_TH1_Human0.90936346
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89770911
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89337051
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88352285
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86605601
94TTF2_22483619_ChIP-Seq_HELA_Human0.86422825
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85510341
96HTT_18923047_ChIP-ChIP_STHdh_Human0.85036648
97E2F1_20622854_ChIP-Seq_HELA_Human0.84877578
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84193937
99MAF_26560356_Chip-Seq_TH2_Human0.83557486
100TAF2_19829295_ChIP-Seq_ESCs_Human0.82496751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.32053820
2MP0002138_abnormal_hepatobiliary_system3.78521251
3MP0005084_abnormal_gallbladder_morpholo2.73548245
4MP0001835_abnormal_antigen_presentation2.52307051
5MP0002148_abnormal_hypersensitivity_rea2.47882672
6MP0009333_abnormal_splenocyte_physiolog2.46723742
7MP0005000_abnormal_immune_tolerance2.44466576
8MP0000685_abnormal_immune_system2.42858598
9MP0001790_abnormal_immune_system2.37369182
10MP0005387_immune_system_phenotype2.37369182
11MP0002723_abnormal_immune_serum2.27914597
12MP0009785_altered_susceptibility_to2.27292527
13MP0002653_abnormal_ependyma_morphology2.21323127
14MP0001800_abnormal_humoral_immune2.15742406
15MP0006082_CNS_inflammation2.10326241
16MP0003693_abnormal_embryo_hatching2.04541572
17MP0008877_abnormal_DNA_methylation2.03331783
18MP0004947_skin_inflammation2.01169533
19MP0000569_abnormal_digit_pigmentation2.00856391
20MP0002420_abnormal_adaptive_immunity1.99037621
21MP0001819_abnormal_immune_cell1.97943859
22MP0003172_abnormal_lysosome_physiology1.97490661
23MP0002876_abnormal_thyroid_physiology1.95476152
24MP0002928_abnormal_bile_duct1.89756529
25MP0008058_abnormal_DNA_repair1.88997390
26MP0003303_peritoneal_inflammation1.82303222
27MP0001853_heart_inflammation1.79719031
28MP0002398_abnormal_bone_marrow1.77216698
29MP0003786_premature_aging1.71997624
30MP0002452_abnormal_antigen_presenting1.71258005
31MP0005310_abnormal_salivary_gland1.68209308
32MP0002163_abnormal_gland_morphology1.66260119
33MP0003011_delayed_dark_adaptation1.65789601
34MP0006292_abnormal_olfactory_placode1.65553257
35MP0003763_abnormal_thymus_physiology1.65318260
36MP0001873_stomach_inflammation1.63512730
37MP0000716_abnormal_immune_system1.62170997
38MP0005025_abnormal_response_to1.58289758
39MP0000689_abnormal_spleen_morphology1.55185865
40MP0001845_abnormal_inflammatory_respons1.54156735
41MP0004147_increased_porphyrin_level1.53770035
42MP0003195_calcinosis1.52383028
43MP0005464_abnormal_platelet_physiology1.50875671
44MP0000372_irregular_coat_pigmentation1.46964512
45MP0006072_abnormal_retinal_apoptosis1.46056912
46MP0002405_respiratory_system_inflammati1.44716113
47MP0002429_abnormal_blood_cell1.43156810
48MP0002722_abnormal_immune_system1.39500875
49MP0005075_abnormal_melanosome_morpholog1.39304041
50MP0006035_abnormal_mitochondrial_morpho1.37423299
51MP0000703_abnormal_thymus_morphology1.36231332
52MP0010307_abnormal_tumor_latency1.24334531
53MP0000465_gastrointestinal_hemorrhage1.21290018
54MP0002006_tumorigenesis1.20471740
55MP0008469_abnormal_protein_level1.19044699
56MP0005174_abnormal_tail_pigmentation1.18817146
57MP0003724_increased_susceptibility_to1.14487340
58MP0009765_abnormal_xenobiotic_induced1.13959698
59MP0003111_abnormal_nucleus_morphology1.13548543
60MP0003252_abnormal_bile_duct1.10760082
61MP0002166_altered_tumor_susceptibility1.08433366
62MP0000013_abnormal_adipose_tissue1.07803237
63MP0004381_abnormal_hair_follicle1.05757082
64MP0003866_abnormal_defecation1.05534832
65MP0005551_abnormal_eye_electrophysiolog1.05235509
66MP0002019_abnormal_tumor_incidence1.05036267
67MP0000015_abnormal_ear_pigmentation1.04886613
68MP0008007_abnormal_cellular_replicative1.03351371
69MP0001986_abnormal_taste_sensitivity1.03027188
70MP0002693_abnormal_pancreas_physiology1.02072167
71MP0003879_abnormal_hair_cell1.01562855
72MP0005379_endocrine/exocrine_gland_phen0.99672216
73MP0003436_decreased_susceptibility_to0.98084893
74MP0005253_abnormal_eye_physiology0.97816152
75MP0002419_abnormal_innate_immunity0.96880939
76MP0002736_abnormal_nociception_after0.95731911
77MP0009763_increased_sensitivity_to0.95372877
78MP0009764_decreased_sensitivity_to0.93145874
79MP0001188_hyperpigmentation0.92994309
80MP0008872_abnormal_physiological_respon0.92314345
81MP0005410_abnormal_fertilization0.89729401
82MP0001968_abnormal_touch/_nociception0.87675102
83MP0010155_abnormal_intestine_physiology0.87541091
84MP0001529_abnormal_vocalization0.85478653
85MP0002095_abnormal_skin_pigmentation0.80273936
86MP0003448_altered_tumor_morphology0.78486556
87MP0001919_abnormal_reproductive_system0.77586599
88MP0005636_abnormal_mineral_homeostasis0.76822041
89MP0010094_abnormal_chromosome_stability0.74886868
90MP0001881_abnormal_mammary_gland0.74185306
91MP0004808_abnormal_hematopoietic_stem0.73308153
92MP0002139_abnormal_hepatobiliary_system0.72526271
93MP0001765_abnormal_ion_homeostasis0.71191853
94MP0002254_reproductive_system_inflammat0.71125917
95MP0001727_abnormal_embryo_implantation0.69663981
96MP0003718_maternal_effect0.69118732
97MP0004145_abnormal_muscle_electrophysio0.66892239
98MP0000427_abnormal_hair_cycle0.66019952
99MP0002277_abnormal_respiratory_mucosa0.65297333
100MP0000383_abnormal_hair_follicle0.63279060

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)3.97699249
2Optic neuritis (HP:0100653)3.97699249
3Abnormality of T cell number (HP:0011839)3.86194253
4Fibular aplasia (HP:0002990)3.86018149
5Delayed CNS myelination (HP:0002188)3.74172952
6Carpal bone hypoplasia (HP:0001498)3.72290209
7T lymphocytopenia (HP:0005403)3.67548666
8Eosinophilia (HP:0001880)3.61258589
9Type I transferrin isoform profile (HP:0003642)3.60621704
10IgG deficiency (HP:0004315)3.51357901
11Abnormality of eosinophils (HP:0001879)3.48418327
12Pancreatic cysts (HP:0001737)3.47182884
13Aplasia/hypoplasia of the uterus (HP:0008684)3.37367451
14Supernumerary bones of the axial skeleton (HP:0009144)3.34315249
15Orchitis (HP:0100796)3.32566607
16Increased intramyocellular lipid droplets (HP:0012240)3.31983444
17Bile duct proliferation (HP:0001408)3.26598919
18Abnormal biliary tract physiology (HP:0012439)3.26598919
19Aplastic anemia (HP:0001915)3.19081135
20Abnormal protein glycosylation (HP:0012346)3.12871194
21Abnormal glycosylation (HP:0012345)3.12871194
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.12871194
23Abnormal protein N-linked glycosylation (HP:0012347)3.12871194
24Anhidrosis (HP:0000970)3.11977618
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11140422
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11140422
27Myositis (HP:0100614)3.09012532
28Renal cortical cysts (HP:0000803)3.05464692
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.03048454
30Progressive inability to walk (HP:0002505)3.03011934
31Granulocytopenia (HP:0001913)3.02455036
32Supernumerary ribs (HP:0005815)3.01994440
33Increased IgM level (HP:0003496)2.88702715
34Increased muscle lipid content (HP:0009058)2.84519728
35Oral leukoplakia (HP:0002745)2.82710519
36Keratoconjunctivitis (HP:0001096)2.81425450
37Keratoconjunctivitis sicca (HP:0001097)2.78850312
38Severe combined immunodeficiency (HP:0004430)2.78237716
39Arterial thrombosis (HP:0004420)2.66895735
40Abnormality of the renal cortex (HP:0011035)2.64179165
41Abnormality of T cells (HP:0002843)2.61363353
42Increased hepatocellular lipid droplets (HP:0006565)2.60752286
43Renal Fanconi syndrome (HP:0001994)2.50310932
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48003487
45Encephalitis (HP:0002383)2.46896746
46Aplasia/hypoplasia of the humerus (HP:0006507)2.46419462
47Facial diplegia (HP:0001349)2.46319561
48Combined immunodeficiency (HP:0005387)2.42102295
49Lipid accumulation in hepatocytes (HP:0006561)2.35073715
50Fused cervical vertebrae (HP:0002949)2.34382650
51Short tibia (HP:0005736)2.31447397
52Hypotrichosis (HP:0001006)2.30456135
53Congenital, generalized hypertrichosis (HP:0004540)2.27212541
54Acute encephalopathy (HP:0006846)2.25042819
55Leukocytosis (HP:0001974)2.24571679
56Keratitis (HP:0000491)2.22686275
57Pustule (HP:0200039)2.21767191
58Chronic diarrhea (HP:0002028)2.21706474
59Hypoproteinemia (HP:0003075)2.21541962
603-Methylglutaconic aciduria (HP:0003535)2.19828673
61Dry hair (HP:0011359)2.19573364
62Abnormality of the renal medulla (HP:0100957)2.16395397
63Nephronophthisis (HP:0000090)2.15878127
64Abnormality of the pons (HP:0007361)2.15110347
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15091389
66Agammaglobulinemia (HP:0004432)2.14644598
67Pancytopenia (HP:0001876)2.14219691
68Aplasia/Hypoplasia of the fibula (HP:0006492)2.09538654
69Abnormality of alanine metabolism (HP:0010916)2.07931703
70Hyperalaninemia (HP:0003348)2.07931703
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07931703
72Tongue fasciculations (HP:0001308)2.06393847
73Autoimmune hemolytic anemia (HP:0001890)2.05459358
74Cutaneous melanoma (HP:0012056)2.04464236
75Joint swelling (HP:0001386)2.04304351
76Increased serum lactate (HP:0002151)2.03737734
77Brittle hair (HP:0002299)2.01791372
78Hemoptysis (HP:0002105)2.00530360
79Arthropathy (HP:0003040)2.00455504
80Hypoplasia of the pons (HP:0012110)2.00320197
81Thyroiditis (HP:0100646)1.99304433
82Autoimmune thrombocytopenia (HP:0001973)1.98413479
83Pulmonary infiltrates (HP:0002113)1.98277956
84Conical tooth (HP:0000698)1.98254947
85IgA deficiency (HP:0002720)1.97383578
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.97258710
87Posterior subcapsular cataract (HP:0007787)1.96924005
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95671364
89Pulmonary fibrosis (HP:0002206)1.92817128
90Stomatitis (HP:0010280)1.90394786
91Seborrheic dermatitis (HP:0001051)1.88763359
92Mitochondrial inheritance (HP:0001427)1.86347501
93Increased CSF lactate (HP:0002490)1.86059468
94Pendular nystagmus (HP:0012043)1.83155578
95Abnormality of dental color (HP:0011073)1.83094431
96Acute necrotizing encephalopathy (HP:0006965)1.82351896
97Abnormal spermatogenesis (HP:0008669)1.82211043
98Exertional dyspnea (HP:0002875)1.81221557
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79945788
100Horseshoe kidney (HP:0000085)1.79239163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK15.49525861
2TXK5.30575691
3MAP4K23.62129151
4MAP3K133.04938413
5SIK22.91530812
6NUAK12.85182363
7KDR2.84990580
8WNK42.82022812
9INSRR2.81698720
10MAP3K142.78278733
11TAOK32.23655315
12MATK2.15292886
13MAP2K62.05875158
14MAPKAPK31.83503560
15IRAK31.81221299
16FES1.70902026
17TLK11.69660487
18IKBKB1.69328575
19PIK3CA1.60442126
20FRK1.54999039
21JAK31.45901235
22CAMKK21.43585275
23IKBKE1.36088721
24MST41.35406707
25PINK11.32151046
26LCK1.31289774
27IRAK41.31274287
28NTRK11.26856022
29NEK21.25521738
30ITK1.18664118
31GRK61.13733986
32ADRBK21.13597418
33CHUK1.12058596
34PRKCQ1.11620411
35TSSK61.08692592
36GRK11.05681097
37TBK11.05216628
38PDK21.02681333
39EEF2K0.99661867
40CSF1R0.99614248
41MUSK0.98506680
42ALK0.91754794
43VRK20.91274035
44MAPK110.87955299
45MAPKAPK50.81655454
46BMPR20.81622664
47SYK0.80023614
48MAP4K10.77692912
49CSK0.77045449
50MAP2K20.74646065
51CDC70.73914411
52TESK20.71261968
53RPS6KA40.69961732
54KIT0.67563436
55PHKG10.64704436
56PHKG20.64704436
57STK240.63140202
58LYN0.60411429
59RAF10.60331399
60RPS6KA50.59329731
61BCR0.58554060
62BCKDK0.56901185
63ZAK0.55901950
64BRSK20.55448489
65SIK30.55408076
66ATR0.55157476
67STK390.53926349
68CDK40.53387785
69ACVR1B0.53331959
70MAP2K10.53208950
71TEC0.52231870
72WNK10.49616782
73EIF2AK10.48774975
74MAPKAPK20.45878300
75MARK30.44341775
76CHEK20.43507634
77CAMKK10.42220838
78BMPR1B0.39586394
79CDK70.38980952
80CSNK2A10.37835585
81TTK0.35457720
82PLK20.34483225
83MAP3K60.32716874
84MAPK130.32387010
85PRKCI0.31887931
86IGF1R0.31845341
87DAPK20.29179006
88ARAF0.27657081
89RPS6KB20.26601204
90BTK0.26586405
91AURKB0.26219928
92RIPK40.25002834
93TIE10.22895750
94CSNK1G30.21092283
95CSNK2A20.21019048
96ERBB20.20794646
97PLK10.20588847
98STK160.20523707
99EIF2AK20.20446720
100STK100.19087784

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.88980316
2Primary immunodeficiency_Homo sapiens_hsa053403.82336384
3Autoimmune thyroid disease_Homo sapiens_hsa053203.33041699
4Allograft rejection_Homo sapiens_hsa053303.25201122
5Proteasome_Homo sapiens_hsa030503.20140963
6Antigen processing and presentation_Homo sapiens_hsa046122.94704028
7Type I diabetes mellitus_Homo sapiens_hsa049402.67624206
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56513996
9Asthma_Homo sapiens_hsa053102.02875331
10Homologous recombination_Homo sapiens_hsa034401.99137131
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96839464
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87508910
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82518376
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.81924618
15RNA polymerase_Homo sapiens_hsa030201.72860113
16Hematopoietic cell lineage_Homo sapiens_hsa046401.71185088
17One carbon pool by folate_Homo sapiens_hsa006701.70867551
18Rheumatoid arthritis_Homo sapiens_hsa053231.70167409
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.66924585
20Selenocompound metabolism_Homo sapiens_hsa004501.63897937
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62912443
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62551888
23Linoleic acid metabolism_Homo sapiens_hsa005911.59267614
24N-Glycan biosynthesis_Homo sapiens_hsa005101.57198448
25Nitrogen metabolism_Homo sapiens_hsa009101.55253023
26Peroxisome_Homo sapiens_hsa041461.55232793
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53275669
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47920603
29Non-homologous end-joining_Homo sapiens_hsa034501.40820539
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34667628
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31643649
32Oxidative phosphorylation_Homo sapiens_hsa001901.28215225
33DNA replication_Homo sapiens_hsa030301.27595872
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24770659
35Pyrimidine metabolism_Homo sapiens_hsa002401.22516610
36T cell receptor signaling pathway_Homo sapiens_hsa046601.19972614
37Base excision repair_Homo sapiens_hsa034101.19281263
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18679885
39Ether lipid metabolism_Homo sapiens_hsa005651.13492694
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12146986
41Spliceosome_Homo sapiens_hsa030401.08974876
42Protein export_Homo sapiens_hsa030601.06245370
43Mismatch repair_Homo sapiens_hsa034301.02812110
44Basal transcription factors_Homo sapiens_hsa030221.00527123
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00415033
46Purine metabolism_Homo sapiens_hsa002300.99452953
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96789876
48Measles_Homo sapiens_hsa051620.94751464
49Arachidonic acid metabolism_Homo sapiens_hsa005900.93840888
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90908491
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.86960370
52Herpes simplex infection_Homo sapiens_hsa051680.86793149
53Phototransduction_Homo sapiens_hsa047440.83229941
54Parkinsons disease_Homo sapiens_hsa050120.77457939
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75817768
56Propanoate metabolism_Homo sapiens_hsa006400.75785892
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74330073
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73775513
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.73380892
60Fatty acid metabolism_Homo sapiens_hsa012120.72586742
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71223590
62Apoptosis_Homo sapiens_hsa042100.70610305
63Epstein-Barr virus infection_Homo sapiens_hsa051690.69402868
64Butanoate metabolism_Homo sapiens_hsa006500.68835492
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68802345
66Nucleotide excision repair_Homo sapiens_hsa034200.66064581
67Leishmaniasis_Homo sapiens_hsa051400.65690403
68TNF signaling pathway_Homo sapiens_hsa046680.62988184
69RNA transport_Homo sapiens_hsa030130.60259013
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55508049
71Lysosome_Homo sapiens_hsa041420.49528513
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49424071
73Fanconi anemia pathway_Homo sapiens_hsa034600.46784539
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.46617397
75RNA degradation_Homo sapiens_hsa030180.46407719
76Viral myocarditis_Homo sapiens_hsa054160.46316855
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44124418
78Systemic lupus erythematosus_Homo sapiens_hsa053220.43962511
79African trypanosomiasis_Homo sapiens_hsa051430.42784695
80Metabolic pathways_Homo sapiens_hsa011000.41491201
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39010218
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38804058
83Influenza A_Homo sapiens_hsa051640.36761483
84Fatty acid biosynthesis_Homo sapiens_hsa000610.35129877
85Staphylococcus aureus infection_Homo sapiens_hsa051500.32821877
86Shigellosis_Homo sapiens_hsa051310.32405651
87Ribosome_Homo sapiens_hsa030100.32158676
88Cardiac muscle contraction_Homo sapiens_hsa042600.31428556
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29850644
90Fatty acid elongation_Homo sapiens_hsa000620.29572558
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28541172
92Huntingtons disease_Homo sapiens_hsa050160.27882733
93Steroid biosynthesis_Homo sapiens_hsa001000.25500506
94ABC transporters_Homo sapiens_hsa020100.24865524
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24012026
96B cell receptor signaling pathway_Homo sapiens_hsa046620.23427377
97Viral carcinogenesis_Homo sapiens_hsa052030.23380534
98Glutathione metabolism_Homo sapiens_hsa004800.22890161
99Ovarian steroidogenesis_Homo sapiens_hsa049130.22873734
100Chemokine signaling pathway_Homo sapiens_hsa040620.22023559

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