GNS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)4.14715117
2oligosaccharide catabolic process (GO:0009313)3.99147245
3apoptotic cell clearance (GO:0043277)3.82788654
4glycolipid catabolic process (GO:0019377)3.72917918
5regulation of interferon-beta biosynthetic process (GO:0045357)3.69173096
6detection of molecule of bacterial origin (GO:0032490)3.63067497
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58772355
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58772355
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.58772355
10modulation by symbiont of host immune response (GO:0052553)3.58772355
11positive regulation by symbiont of host defense response (GO:0052509)3.58772355
12modulation by symbiont of host defense response (GO:0052031)3.58772355
13positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.55047936
14Golgi transport vesicle coating (GO:0048200)3.51470204
15COPI coating of Golgi vesicle (GO:0048205)3.51470204
16cellular response to thyroid hormone stimulus (GO:0097067)3.48284766
17low-density lipoprotein particle clearance (GO:0034383)3.45818698
18barbed-end actin filament capping (GO:0051016)3.41506184
19protein carboxylation (GO:0018214)3.38132745
20peptidyl-glutamic acid carboxylation (GO:0017187)3.38132745
21response to peptidoglycan (GO:0032494)3.34781546
22alpha-linolenic acid metabolic process (GO:0036109)3.25132208
23ceramide catabolic process (GO:0046514)3.22422507
24mannose metabolic process (GO:0006013)3.19975095
25regulation of cholesterol storage (GO:0010885)3.16851696
26macrophage activation involved in immune response (GO:0002281)3.13023849
27negative regulation of interleukin-12 production (GO:0032695)3.07931573
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03397143
29amino sugar catabolic process (GO:0046348)3.01641418
30positive regulation of cellular amide metabolic process (GO:0034250)3.01391880
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96749512
32complement activation, alternative pathway (GO:0006957)2.96167634
33peptide catabolic process (GO:0043171)2.95674639
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94299291
35L-phenylalanine catabolic process (GO:0006559)2.94299291
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94033484
37L-alpha-amino acid transmembrane transport (GO:1902475)2.93800754
38response to thyroid hormone (GO:0097066)2.93506214
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92676291
40plasma lipoprotein particle clearance (GO:0034381)2.91823696
41pinocytosis (GO:0006907)2.89754164
42positive regulation of receptor recycling (GO:0001921)2.89040750
43macroautophagy (GO:0016236)2.88267800
44regulation of mononuclear cell migration (GO:0071675)2.86694138
45regulation of cholesterol homeostasis (GO:2000188)2.86267541
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86132130
47positive regulation of fatty acid beta-oxidation (GO:0032000)2.85968207
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83913998
49L-phenylalanine metabolic process (GO:0006558)2.83913998
50phospholipid homeostasis (GO:0055091)2.83517650
51adhesion of symbiont to host (GO:0044406)2.82867453
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79104666
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78862930
54regulation of protein activation cascade (GO:2000257)2.77587318
55regulation of fatty acid beta-oxidation (GO:0031998)2.77171391
56iron ion import (GO:0097286)2.77080047
57activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76432337
58regulation of complement activation (GO:0030449)2.75444534
59detection of external biotic stimulus (GO:0098581)2.74625118
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.71656834
61negative regulation of fibrinolysis (GO:0051918)2.70973286
62virion attachment to host cell (GO:0019062)2.70376775
63adhesion of symbiont to host cell (GO:0044650)2.70376775
64neutrophil activation involved in immune response (GO:0002283)2.70205260
65cell adhesion mediated by integrin (GO:0033627)2.69992610
66positive regulation of p38MAPK cascade (GO:1900745)2.66866073
67amyloid precursor protein catabolic process (GO:0042987)2.66423399
68lysine catabolic process (GO:0006554)2.65944325
69lysine metabolic process (GO:0006553)2.65944325
70response to laminar fluid shear stress (GO:0034616)2.65914486
71positive regulation of leukocyte degranulation (GO:0043302)2.65891192
72regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63921109
73hyaluronan catabolic process (GO:0030214)2.63552381
74sulfur amino acid catabolic process (GO:0000098)2.62451093
75reverse cholesterol transport (GO:0043691)2.60476399
76cellular extravasation (GO:0045123)2.58530408
77membrane lipid catabolic process (GO:0046466)2.58122871
78regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57835343
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56914881
80positive regulation of interferon-alpha production (GO:0032727)2.56828175
81positive regulation of nuclease activity (GO:0032075)2.56700733
82positive regulation of cholesterol efflux (GO:0010875)2.55686012
834-hydroxyproline metabolic process (GO:0019471)2.53363421
84sphingolipid catabolic process (GO:0030149)2.51857852
85urea cycle (GO:0000050)2.51758984
86urea metabolic process (GO:0019627)2.51758984
87detection of other organism (GO:0098543)2.51016108
88production of molecular mediator involved in inflammatory response (GO:0002532)2.50603662
89* keratan sulfate catabolic process (GO:0042340)2.50430120
90lipoprotein metabolic process (GO:0042157)2.48101975
91endoplasmic reticulum unfolded protein response (GO:0030968)2.47116420
92phospholipid efflux (GO:0033700)2.47033673
93cysteine metabolic process (GO:0006534)2.46071467
94aromatic amino acid family catabolic process (GO:0009074)2.45690085
95cellular modified amino acid catabolic process (GO:0042219)2.45426930
96regulation of macrophage chemotaxis (GO:0010758)2.45145591
97positive regulation of fatty acid oxidation (GO:0046321)2.43754187
98microglial cell activation (GO:0001774)2.41986486
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41677936
100high-density lipoprotein particle remodeling (GO:0034375)2.41549974
101regulation of interferon-alpha production (GO:0032647)2.41162686
102homocysteine metabolic process (GO:0050667)2.40384245
103skin morphogenesis (GO:0043589)2.40339196
104negative regulation of lipid storage (GO:0010888)2.39868238
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39563521
106positive regulation of lipid catabolic process (GO:0050996)2.38832498
107cellular response to unfolded protein (GO:0034620)2.37417208
108stress fiber assembly (GO:0043149)2.37371383
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37141138
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37141138
111cholesterol efflux (GO:0033344)2.36890083
112negative regulation of protein localization to plasma membrane (GO:1903077)2.36450760
113endodermal cell differentiation (GO:0035987)2.35349050
114regulation of leukocyte degranulation (GO:0043300)2.34695025
115growth hormone receptor signaling pathway (GO:0060396)2.34591010
116lipoprotein transport (GO:0042953)2.34494193
117detection of biotic stimulus (GO:0009595)2.34296290
118ER-nucleus signaling pathway (GO:0006984)2.33892338
119N-acetylneuraminate metabolic process (GO:0006054)2.33580432
120positive regulation of hemostasis (GO:1900048)2.33517200
121positive regulation of blood coagulation (GO:0030194)2.33517200
122regulation of early endosome to late endosome transport (GO:2000641)2.32825908
123positive regulation of extracellular matrix organization (GO:1903055)2.32473502
124T-helper 1 type immune response (GO:0042088)2.32319411
125protein-lipid complex assembly (GO:0065005)2.32309395
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30595913
127regulation of macrophage cytokine production (GO:0010935)2.29307964
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29167728
129protein retention in ER lumen (GO:0006621)2.28975877
130positive regulation of sterol transport (GO:0032373)2.28951463
131positive regulation of cholesterol transport (GO:0032376)2.28951463
132tricarboxylic acid metabolic process (GO:0072350)2.28769097
133regulation of nuclease activity (GO:0032069)2.27987194
134COPII vesicle coating (GO:0048208)2.27915323
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27732816
136response to lipoprotein particle (GO:0055094)2.27301257
137protein localization to endosome (GO:0036010)2.27213433
138positive regulation of coagulation (GO:0050820)2.26600706
139regulation of fibrinolysis (GO:0051917)2.26376816
140negative regulation of nitric oxide biosynthetic process (GO:0045019)2.25921466
141basement membrane organization (GO:0071711)2.25880016
142tyrosine metabolic process (GO:0006570)2.25825749
143response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25720046
144response to host immune response (GO:0052572)2.25720046
145wound healing, spreading of epidermal cells (GO:0035313)2.24349855
146glyoxylate metabolic process (GO:0046487)2.24226731
147complement activation, classical pathway (GO:0006958)2.23925340
148nitrogen cycle metabolic process (GO:0071941)2.23575263
149positive regulation of monocyte chemotaxis (GO:0090026)2.23116397
150I-kappaB phosphorylation (GO:0007252)2.22908846
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22869891
152cortical actin cytoskeleton organization (GO:0030866)2.22796619
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22504887
154regulation of vitamin D biosynthetic process (GO:0060556)2.22444701
155complement activation (GO:0006956)2.22265173
156membrane protein ectodomain proteolysis (GO:0006509)2.22089985
157antigen processing and presentation of endogenous antigen (GO:0019883)2.22021514
158kynurenine metabolic process (GO:0070189)2.21579293
159negative regulation of lipid transport (GO:0032369)2.21500808
160positive regulation of histone deacetylation (GO:0031065)2.21468178
161osteoclast differentiation (GO:0030316)2.20004776
162regulation of T-helper 2 cell differentiation (GO:0045628)2.19147273
163macrophage activation (GO:0042116)2.17526087
164substrate-dependent cell migration (GO:0006929)2.17233291
165bile acid biosynthetic process (GO:0006699)2.16858371
166cellular response to topologically incorrect protein (GO:0035967)2.16393680
167regulation of monocyte chemotaxis (GO:0090025)2.16141958
168positive regulation of gamma-delta T cell activation (GO:0046645)2.13562874
169regulation of extracellular matrix disassembly (GO:0010715)2.11693449
170positive regulation of macrophage cytokine production (GO:0060907)2.10427326
171regulation of mast cell degranulation (GO:0043304)2.09718292
172decidualization (GO:0046697)2.09019042
173glial cell migration (GO:0008347)2.07181058
174positive regulation of phagocytosis (GO:0050766)2.04811018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.80642293
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.82579156
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.39840670
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.37950166
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96884375
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.87345777
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80388278
8CLOCK_20551151_ChIP-Seq_293T_Human2.51290363
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37248172
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34206744
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.33803659
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.30047581
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.26540372
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.24534886
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22772378
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19897347
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.19139875
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17780402
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10294812
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95601456
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91176021
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85102992
23GATA1_22025678_ChIP-Seq_K562_Human1.82840116
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81231633
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69891659
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67535375
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65192276
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.62929353
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.60671754
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.60574011
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58634091
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57968401
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.46814168
34LXR_22292898_ChIP-Seq_THP-1_Human1.45589589
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.43119893
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.41591109
37* GATA2_21666600_ChIP-Seq_HMVEC_Human1.39532671
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36508692
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36500586
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36436579
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35578263
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32745350
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.31774652
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31666155
45SPI1_23127762_ChIP-Seq_K562_Human1.30183332
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29744735
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29744735
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29368944
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26869269
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.23962781
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23603391
52GATA1_19941826_ChIP-Seq_K562_Human1.22283468
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21884311
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21050715
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19846435
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19353905
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19353905
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19004990
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18489045
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17659609
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17626601
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17401078
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15978083
64VDR_24787735_ChIP-Seq_THP-1_Human1.15396715
65CJUN_26792858_Chip-Seq_BT549_Human1.14094995
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14053408
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13898801
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13210012
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12242471
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.11862067
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.11688314
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.11688314
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.10730758
74* SOX2_20726797_ChIP-Seq_SW620_Human1.10471433
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10355197
76* TFEB_21752829_ChIP-Seq_HELA_Human1.10061333
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.09659189
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.08901267
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08188194
80RACK7_27058665_Chip-Seq_MCF-7_Human1.07464591
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06859322
82TCF7_22412390_ChIP-Seq_EML_Mouse1.06338917
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06037115
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05484242
85KDM2B_26808549_Chip-Seq_DND41_Human1.05461471
86SPI1_23547873_ChIP-Seq_NB4_Human1.05351018
87BRD4_25478319_ChIP-Seq_HGPS_Human1.04394715
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03411286
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03210809
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00579644
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00490992
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99068544
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98876248
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98250763
95* GATA2_19941826_ChIP-Seq_K562_Human0.97363422
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.97239028
97* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97216714
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97075797
99* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96649708
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96316221
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95639709
102VDR_21846776_ChIP-Seq_THP-1_Human0.94919681
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94843397
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93821975
105VDR_24763502_ChIP-Seq_THP-1_Human0.92735045
106* KDM2B_26808549_Chip-Seq_K562_Human0.92115460
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90745145
108RUNX_20019798_ChIP-Seq_JUKART_Human0.88618077
109* PU_27001747_Chip-Seq_BMDM_Mouse0.87861366
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87549660
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85156951
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84405786
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84057406
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83989256
115GATA4_25053715_ChIP-Seq_YYC3_Human0.83430806
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83260391
117ATF3_27146783_Chip-Seq_COLON_Human0.82889085
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82397627
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.81835901
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81752379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.89717425
2MP0008438_abnormal_cutaneous_collagen3.49532031
3MP0002139_abnormal_hepatobiliary_system3.38415474
4MP0009840_abnormal_foam_cell3.18702439
5MP0005360_urolithiasis3.07353985
6MP0003191_abnormal_cellular_cholesterol3.05003912
7MP0003705_abnormal_hypodermis_morpholog2.97997885
8MP0003172_abnormal_lysosome_physiology2.76491721
9MP0003300_gastrointestinal_ulcer2.75596070
10MP0005365_abnormal_bile_salt2.50468046
11MP0003252_abnormal_bile_duct2.44371594
12MP0005085_abnormal_gallbladder_physiolo2.14351373
13MP0005451_abnormal_body_composition2.14150836
14MP0003195_calcinosis2.02921984
15MP0003303_peritoneal_inflammation1.97414009
16MP0003828_pulmonary_edema1.95485246
17MP0010329_abnormal_lipoprotein_level1.91115915
18MP0008875_abnormal_xenobiotic_pharmacok1.89601014
19MP0005257_abnormal_intraocular_pressure1.87872696
20MP0001958_emphysema1.77845248
21MP0003566_abnormal_cell_adhesion1.75809347
22MP0002877_abnormal_melanocyte_morpholog1.72606522
23MP0003329_amyloid_beta_deposits1.68789176
24MP0006082_CNS_inflammation1.68554153
25MP0005275_abnormal_skin_tensile1.61733030
26MP0000604_amyloidosis1.59962149
27MP0009785_altered_susceptibility_to1.59297277
28MP0002148_abnormal_hypersensitivity_rea1.58554390
29MP0005083_abnormal_biliary_tract1.55204313
30MP0008004_abnormal_stomach_pH1.54688689
31MP0003279_aneurysm1.54010235
32MP0005670_abnormal_white_adipose1.46520379
33MP0003436_decreased_susceptibility_to1.46215798
34MP0000609_abnormal_liver_physiology1.43298074
35MP0008260_abnormal_autophagy1.40443910
36MP0009643_abnormal_urine_homeostasis1.39988168
37MP0005025_abnormal_response_to1.37675664
38MP0004883_abnormal_blood_vessel1.36565628
39MP0003448_altered_tumor_morphology1.35298446
40MP0005332_abnormal_amino_acid1.34825221
41MP0003690_abnormal_glial_cell1.34049575
42MP0006054_spinal_hemorrhage1.33463430
43MP0002118_abnormal_lipid_homeostasis1.33397911
44MP0004130_abnormal_muscle_cell1.33376993
45MP0001533_abnormal_skeleton_physiology1.30621088
46MP0002254_reproductive_system_inflammat1.29900315
47MP0000858_altered_metastatic_potential1.29898339
48MP0003045_fibrosis1.29391747
49MP0000685_abnormal_immune_system1.28417984
50MP0003075_altered_response_to1.28146043
51MP0002138_abnormal_hepatobiliary_system1.27718672
52MP0000569_abnormal_digit_pigmentation1.27445478
53MP0003183_abnormal_peptide_metabolism1.25075292
54MP0004510_myositis1.23506638
55MP0003950_abnormal_plasma_membrane1.22310057
56MP0002998_abnormal_bone_remodeling1.21506787
57MP0003453_abnormal_keratinocyte_physiol1.21348505
58MP0002909_abnormal_adrenal_gland1.21226236
59MP0008961_abnormal_basal_metabolism1.19053647
60MP0002419_abnormal_innate_immunity1.19040578
61MP0010352_gastrointestinal_tract_polyps1.17828251
62MP0005464_abnormal_platelet_physiology1.17575913
63MP0004185_abnormal_adipocyte_glucose1.17309364
64MP0001666_abnormal_nutrient_absorption1.16667853
65MP0004019_abnormal_vitamin_homeostasis1.16052459
66MP0001835_abnormal_antigen_presentation1.15713233
67MP0001756_abnormal_urination1.14903556
68MP0009780_abnormal_chondrocyte_physiolo1.14383992
69MP0005165_increased_susceptibility_to1.14290838
70MP0001542_abnormal_bone_strength1.13788810
71MP0002896_abnormal_bone_mineralization1.13531327
72MP0002452_abnormal_antigen_presenting1.12916267
73MP0003091_abnormal_cell_migration1.12524698
74MP0000013_abnormal_adipose_tissue1.11380022
75MP0002168_other_aberrant_phenotype1.10867524
76MP0005319_abnormal_enzyme/_coenzyme1.08671484
77MP0010368_abnormal_lymphatic_system1.07543217
78MP0002090_abnormal_vision1.05429750
79MP0005023_abnormal_wound_healing1.03284494
80MP0005076_abnormal_cell_differentiation1.02718505
81MP0008469_abnormal_protein_level1.01939783
82MP0004272_abnormal_basement_membrane1.01913059
83MP0001853_heart_inflammation1.01904488
84MP0000465_gastrointestinal_hemorrhage1.01342591
85MP0005666_abnormal_adipose_tissue1.01186151
86MP0009384_cardiac_valve_regurgitation1.00380745
87MP0001849_ear_inflammation0.99810527
88MP0004947_skin_inflammation0.99583090
89MP0002928_abnormal_bile_duct0.99441850
90MP0010234_abnormal_vibrissa_follicle0.98697446
91MP0000343_altered_response_to0.98452162
92MP0010155_abnormal_intestine_physiology0.97159808
93MP0002295_abnormal_pulmonary_circulatio0.96409970
94MP0003283_abnormal_digestive_organ0.95637492
95MP0002723_abnormal_immune_serum0.95274202
96MP0003656_abnormal_erythrocyte_physiolo0.94897834
97MP0005390_skeleton_phenotype0.94600566
98MP0002078_abnormal_glucose_homeostasis0.93939817
99MP0002405_respiratory_system_inflammati0.93147643
100MP0005409_darkened_coat_color0.92961531
101MP0005167_abnormal_blood-brain_barrier0.92854252
102MP0005375_adipose_tissue_phenotype0.91963278
103MP0001790_abnormal_immune_system0.91937565
104MP0005387_immune_system_phenotype0.91937565
105MP0002136_abnormal_kidney_physiology0.91797369
106MP0004233_abnormal_muscle_weight0.91536972
107MP0005584_abnormal_enzyme/coenzyme_acti0.91242234
108MP0003724_increased_susceptibility_to0.90493298
109MP0000598_abnormal_liver_morphology0.89583569
110MP0005220_abnormal_exocrine_pancreas0.89553596
111MP0000767_abnormal_smooth_muscle0.89149374
112MP0002693_abnormal_pancreas_physiology0.88731259
113MP0001915_intracranial_hemorrhage0.88702273
114MP0005595_abnormal_vascular_smooth0.88189202
115MP0000920_abnormal_myelination0.84185516
116MP0004858_abnormal_nervous_system0.82983455
117MP0005166_decreased_susceptibility_to0.82733896
118MP0001944_abnormal_pancreas_morphology0.82628639
119MP0001845_abnormal_inflammatory_respons0.80367899
120MP0009278_abnormal_bone_marrow0.80116400
121MP0000003_abnormal_adipose_tissue0.79912841
122MP0000249_abnormal_blood_vessel0.79493219
123MP0001819_abnormal_immune_cell0.78787864
124MP0009764_decreased_sensitivity_to0.78495703
125MP0003634_abnormal_glial_cell0.78080648
126MP0002420_abnormal_adaptive_immunity0.78079890
127MP0005164_abnormal_response_to0.77892948
128MP0005334_abnormal_fat_pad0.77542840
129MP0002971_abnormal_brown_adipose0.77072810
130MP0005000_abnormal_immune_tolerance0.76793781
131MP0010386_abnormal_urinary_bladder0.76589289
132MP0005503_abnormal_tendon_morphology0.76491475
133MP0001851_eye_inflammation0.76074636
134MP0002837_dystrophic_cardiac_calcinosis0.75686617
135MP0005397_hematopoietic_system_phenotyp0.75624319
136MP0001545_abnormal_hematopoietic_system0.75624319
137MP0000371_diluted_coat_color0.74750608
138MP0005248_abnormal_Harderian_gland0.74340272
139MP0005671_abnormal_response_to0.73716539
140MP0002933_joint_inflammation0.73443672
141MP0003795_abnormal_bone_structure0.72470617
142MP0001800_abnormal_humoral_immune0.71876672
143MP0002332_abnormal_exercise_endurance0.68465376

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.68090971
2Increased cerebral lipofuscin (HP:0011813)4.38684092
3Complement deficiency (HP:0004431)4.06399827
4Cerebral aneurysm (HP:0004944)3.78481683
5* Dysostosis multiplex (HP:0000943)3.75575410
6Vacuolated lymphocytes (HP:0001922)3.66903092
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.56977162
8Glomerulonephritis (HP:0000099)3.53985525
9* Mucopolysacchariduria (HP:0008155)3.49893623
10* Urinary glycosaminoglycan excretion (HP:0003541)3.49893623
11Deep venous thrombosis (HP:0002625)3.34867012
12Abnormality of glycolipid metabolism (HP:0010969)3.34220204
13Abnormality of liposaccharide metabolism (HP:0010968)3.34220204
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.34220204
15* Abnormality of polysaccharide metabolism (HP:0011012)3.32049703
16* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.32049703
17* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.32049703
18Xanthomatosis (HP:0000991)3.20121136
19Abnormality of complement system (HP:0005339)3.16004305
20Myocardial infarction (HP:0001658)3.15837743
21Retinal atrophy (HP:0001105)2.91049916
22Aortic aneurysm (HP:0004942)2.84184958
23Premature rupture of membranes (HP:0001788)2.83998106
24Cervical subluxation (HP:0003308)2.82084273
25Protrusio acetabuli (HP:0003179)2.82053717
26Hypoglycemic coma (HP:0001325)2.74665007
27Axonal loss (HP:0003447)2.69895301
28Nephritis (HP:0000123)2.63602362
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57574418
30Arterial tortuosity (HP:0005116)2.55610807
31Skin nodule (HP:0200036)2.52544226
32Recurrent gram-negative bacterial infections (HP:0005420)2.52152936
33Mitral stenosis (HP:0001718)2.50968170
34Vascular tortuosity (HP:0004948)2.50709769
35Abnormality of the common coagulation pathway (HP:0010990)2.50593340
36Hematochezia (HP:0002573)2.49942202
37Aortic dissection (HP:0002647)2.48003871
38Intrahepatic cholestasis (HP:0001406)2.43686464
39Global brain atrophy (HP:0002283)2.43404927
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41285129
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39364842
42Hypoglycemic seizures (HP:0002173)2.39067550
43Aneurysm (HP:0002617)2.38503770
44Loss of speech (HP:0002371)2.35102475
45Hypoalphalipoproteinemia (HP:0003233)2.32681088
46Nuclear cataract (HP:0100018)2.32274041
47Ketoacidosis (HP:0001993)2.32142802
48Peritonitis (HP:0002586)2.29045083
49Striae distensae (HP:0001065)2.25791222
50Mitral valve prolapse (HP:0001634)2.23297425
51Interstitial pulmonary disease (HP:0006530)2.21810737
52Hydroxyprolinuria (HP:0003080)2.20796542
53Abnormality of proline metabolism (HP:0010907)2.20796542
54Ketosis (HP:0001946)2.20701632
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18895110
56Spontaneous hematomas (HP:0007420)2.18450526
57Increased CSF protein (HP:0002922)2.16431250
58Orchitis (HP:0100796)2.16323953
59Gingivitis (HP:0000230)2.16184674
60Joint hemorrhage (HP:0005261)2.16040573
61Abnormality of the intrinsic pathway (HP:0010989)2.13672962
62Hyperinsulinemic hypoglycemia (HP:0000825)2.12766849
63Hyperlipoproteinemia (HP:0010980)2.12461928
64Upper motor neuron abnormality (HP:0002127)2.12390155
65Bone pain (HP:0002653)2.11739972
66Eczematoid dermatitis (HP:0000976)2.10574297
67Apathy (HP:0000741)2.08944304
68Progressive neurologic deterioration (HP:0002344)2.08638294
69Diminished motivation (HP:0000745)2.05925326
70Absent frontal sinuses (HP:0002688)2.04898966
71Spondylolisthesis (HP:0003302)2.04806789
72Sensorimotor neuropathy (HP:0007141)1.98202776
73Vertebral compression fractures (HP:0002953)1.98176273
74Disproportionate tall stature (HP:0001519)1.97210190
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96576550
76Hand muscle atrophy (HP:0009130)1.96518855
77Abnormality of purine metabolism (HP:0004352)1.96248600
78Purpura (HP:0000979)1.95702480
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.95276416
80Osteolytic defects of the hand bones (HP:0009699)1.95276416
81Shallow orbits (HP:0000586)1.95088573
82Esophageal varix (HP:0002040)1.94568479
83Epidermoid cyst (HP:0200040)1.93775509
84Myositis (HP:0100614)1.93436718
85Turricephaly (HP:0000262)1.91613513
86Tetraparesis (HP:0002273)1.91411964
87Recurrent bacterial skin infections (HP:0005406)1.91245286
88Dilatation of the ascending aorta (HP:0005111)1.90849706
89Wormian bones (HP:0002645)1.90044418
90Amyloidosis (HP:0011034)1.89892284
91Autoimmune thrombocytopenia (HP:0001973)1.89721541
92Protuberant abdomen (HP:0001538)1.88749301
93Broad metatarsal (HP:0001783)1.88540036
94Upper limb amyotrophy (HP:0009129)1.88168784
95Distal upper limb amyotrophy (HP:0007149)1.88168784
96Hyperglycemia (HP:0003074)1.85724242
97Abnormality of macrophages (HP:0004311)1.85238811
98Neurofibrillary tangles (HP:0002185)1.84674133
99Hypercholesterolemia (HP:0003124)1.82960177
100Long toe (HP:0010511)1.82389376
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82123826
102Thoracic kyphosis (HP:0002942)1.82105763
103Cardiomegaly (HP:0001640)1.81306789
104Cerebral inclusion bodies (HP:0100314)1.80371779
105Neuronal loss in central nervous system (HP:0002529)1.79462847
106Late onset (HP:0003584)1.77804501
107J-shaped sella turcica (HP:0002680)1.76274778
108Blue sclerae (HP:0000592)1.75280834
109Thin bony cortex (HP:0002753)1.75167670
110Recurrent abscess formation (HP:0002722)1.74812772
111Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74797991
112Hypolipoproteinemia (HP:0010981)1.74778001
113Short nail (HP:0001799)1.74745773
114Retrobulbar optic neuritis (HP:0100654)1.73830960
115Optic neuritis (HP:0100653)1.73830960
116Polycythemia (HP:0001901)1.73762013
117Disinhibition (HP:0000734)1.73517621
118Mediastinal lymphadenopathy (HP:0100721)1.73446069
119Malnutrition (HP:0004395)1.73230406
120Pathologic fracture (HP:0002756)1.72826778
121Lymphangioma (HP:0100764)1.72322531
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71502144
123Hepatosplenomegaly (HP:0001433)1.71090830
124* Asymmetric septal hypertrophy (HP:0001670)1.68204761
125Conjunctival telangiectasia (HP:0000524)1.67864796
126Flat acetabular roof (HP:0003180)1.66266089
127Mutism (HP:0002300)1.64092256
128Gingival bleeding (HP:0000225)1.64089033
129Subacute progressive viral hepatitis (HP:0006572)1.62726171
130Abnormality of the periventricular white matter (HP:0002518)1.62649733
131Metaphyseal irregularity (HP:0003025)1.62564508
132Recurrent skin infections (HP:0001581)1.62244566
133Prolonged neonatal jaundice (HP:0006579)1.62081832
134* Ovoid vertebral bodies (HP:0003300)1.61883680
135Bilateral sensorineural hearing impairment (HP:0008619)1.60129206
136Ankle contracture (HP:0006466)1.58524057
137Flared iliac wings (HP:0002869)1.57815173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.47560817
2TRIB34.09954727
3TGFBR23.41385919
4PKN22.89866673
5SIK12.55143038
6TAOK32.24991774
7PRPF4B2.24155246
8PTK62.09482839
9CAMK1D2.08535677
10INSRR1.93936387
11EPHB11.90222354
12PDGFRA1.88579333
13RIPK11.86251180
14FGFR41.85547063
15JAK11.83577727
16TYK21.82873502
17TTN1.75321098
18SCYL21.74571881
19TBK11.72955810
20CAMK1G1.65517583
21MAP3K101.43881949
22GRK71.41827009
23MAPK151.38589254
24IRAK31.36320595
25EPHA31.31456244
26FRK1.30820955
27CSF1R1.28051604
28LATS11.27445031
29TAOK21.26730547
30BCKDK1.26517318
31NEK91.22204622
32FGR1.21187335
33MAP3K21.19789057
34ICK1.19702813
35DDR21.18592173
36TIE11.15829618
37LRRK21.14218940
38PTK21.13470994
39TRPM71.13120309
40BLK1.12952164
41JAK21.11904691
42TESK11.11449459
43PAK41.10737426
44IRAK41.08520016
45BMX1.07163050
46KIT1.06340005
47MST1R1.05774142
48FLT31.02239051
49MATK0.96877723
50MAP2K30.96872022
51FGFR30.96323350
52LATS20.95208229
53RET0.94751584
54PRKCH0.93514793
55MAP3K10.91946581
56ZAP700.91807354
57BMPR20.91433536
58MAP4K10.89726764
59CSK0.89308603
60CAMKK10.88915647
61MAP3K30.86734020
62CAMKK20.86387839
63MYLK0.85933311
64MAP3K60.85583873
65KSR20.84445464
66EPHB20.83838823
67MAP3K110.80691979
68PDGFRB0.79666911
69TAOK10.78647087
70PAK20.78128083
71JAK30.76360637
72FER0.75212171
73NTRK10.74931336
74MET0.74796478
75HCK0.74044091
76EEF2K0.73731668
77MTOR0.71459053
78PRKG20.70666529
79YES10.70101707
80RIPK40.69843235
81IRAK10.69438328
82CDK60.69063006
83PDPK10.68829064
84PRKD20.68397628
85MAP3K130.68293018
86HIPK20.67740956
87GSK3A0.67712020
88AKT30.66601373
89IRAK20.66494641
90MAP3K140.63718334
91NME20.62905609
92PIK3CG0.62842103
93LIMK10.62547230
94DYRK1B0.62098395
95MAP3K50.61288727
96FES0.61153779
97MAPK70.59603488
98MAP3K120.58528810
99SGK30.57936069
100PIM20.57754166
101PRKD30.57732546
102PRKD10.57680141
103EGFR0.57065532
104ERBB40.56024305
105STK100.55674292
106MOS0.55655754
107ACVR1B0.54596686
108MARK20.53728157
109STK380.52847056
110STK30.51980253
111ARAF0.51641235
112PDK20.51609076
113MAP2K10.51393076
114IGF1R0.51363176
115WNK40.50370828
116PDK10.49815285
117KSR10.49007697
118DMPK0.48291669
119ABL20.47221481
120CHUK0.46794890
121PAK30.46285015
122MARK30.43837451
123ITK0.42893185
124PRKAA20.42653970
125INSR0.42172666
126RPS6KA40.40808599
127RPS6KA20.40377382
128IKBKE0.39145472
129ABL10.37503310
130CDK120.37417265
131MAP3K90.36970938
132IKBKB0.36519269
133SRC0.36183633
134SIK20.35177057
135PTK2B0.34555399
136KDR0.34339582
137CDC42BPA0.33896679

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.84219001
2Staphylococcus aureus infection_Homo sapiens_hsa051502.75513235
3* Lysosome_Homo sapiens_hsa041422.51224383
4* Glycosaminoglycan degradation_Homo sapiens_hsa005312.35275201
5Complement and coagulation cascades_Homo sapiens_hsa046102.28230656
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.15139372
7Other glycan degradation_Homo sapiens_hsa005112.06633597
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97154982
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.93820704
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90582131
11Fatty acid degradation_Homo sapiens_hsa000711.72303183
12Caffeine metabolism_Homo sapiens_hsa002321.69458655
13Tryptophan metabolism_Homo sapiens_hsa003801.67136650
14Arginine biosynthesis_Homo sapiens_hsa002201.66631692
15PPAR signaling pathway_Homo sapiens_hsa033201.55089349
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50603881
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36366338
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32837218
19Bile secretion_Homo sapiens_hsa049761.26006252
20Fatty acid metabolism_Homo sapiens_hsa012121.23716314
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21246080
22Osteoclast differentiation_Homo sapiens_hsa043801.16020913
23ABC transporters_Homo sapiens_hsa020101.15834643
24Starch and sucrose metabolism_Homo sapiens_hsa005001.11908782
25Salmonella infection_Homo sapiens_hsa051321.10347604
26Prion diseases_Homo sapiens_hsa050201.08804583
27Insulin resistance_Homo sapiens_hsa049311.07221320
28Sphingolipid metabolism_Homo sapiens_hsa006001.06084175
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.05012603
30Hepatitis C_Homo sapiens_hsa051601.00918231
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00152472
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00051137
33Influenza A_Homo sapiens_hsa051640.99978470
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98270583
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97300521
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97124888
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96764968
38Leishmaniasis_Homo sapiens_hsa051400.95871532
39Butanoate metabolism_Homo sapiens_hsa006500.95442622
40Peroxisome_Homo sapiens_hsa041460.95290484
41Selenocompound metabolism_Homo sapiens_hsa004500.93995009
42Type II diabetes mellitus_Homo sapiens_hsa049300.92889905
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92396451
44Pertussis_Homo sapiens_hsa051330.91684362
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.90947507
46Amoebiasis_Homo sapiens_hsa051460.90328626
47Tuberculosis_Homo sapiens_hsa051520.89773818
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89089529
49Renal cell carcinoma_Homo sapiens_hsa052110.88812764
50Histidine metabolism_Homo sapiens_hsa003400.88601610
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88382538
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88256120
53Prolactin signaling pathway_Homo sapiens_hsa049170.88071062
54Acute myeloid leukemia_Homo sapiens_hsa052210.87424572
55Phagosome_Homo sapiens_hsa041450.87275743
56Sulfur metabolism_Homo sapiens_hsa009200.85984323
57Propanoate metabolism_Homo sapiens_hsa006400.83876143
58Hematopoietic cell lineage_Homo sapiens_hsa046400.83402585
59Lysine degradation_Homo sapiens_hsa003100.83337847
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82671475
61Chemokine signaling pathway_Homo sapiens_hsa040620.82529055
62Allograft rejection_Homo sapiens_hsa053300.81731195
63Fat digestion and absorption_Homo sapiens_hsa049750.81351661
64Hepatitis B_Homo sapiens_hsa051610.80399384
65Viral myocarditis_Homo sapiens_hsa054160.79000592
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78729597
67Malaria_Homo sapiens_hsa051440.78062396
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.76430386
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75605874
70Measles_Homo sapiens_hsa051620.75299443
71Shigellosis_Homo sapiens_hsa051310.75038906
72beta-Alanine metabolism_Homo sapiens_hsa004100.74384831
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.71695998
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70919899
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70804369
76B cell receptor signaling pathway_Homo sapiens_hsa046620.70580351
77Toxoplasmosis_Homo sapiens_hsa051450.70572365
78Small cell lung cancer_Homo sapiens_hsa052220.70534442
79Focal adhesion_Homo sapiens_hsa045100.70343852
80Apoptosis_Homo sapiens_hsa042100.70136177
81African trypanosomiasis_Homo sapiens_hsa051430.69749585
82Chronic myeloid leukemia_Homo sapiens_hsa052200.67795450
83Phenylalanine metabolism_Homo sapiens_hsa003600.67483194
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67095036
85Graft-versus-host disease_Homo sapiens_hsa053320.66892476
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66402047
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65808828
88VEGF signaling pathway_Homo sapiens_hsa043700.65695206
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65177878
90Autoimmune thyroid disease_Homo sapiens_hsa053200.64281711
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64150964
92ECM-receptor interaction_Homo sapiens_hsa045120.63742371
93Proteoglycans in cancer_Homo sapiens_hsa052050.63330041
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61342815
95Ovarian steroidogenesis_Homo sapiens_hsa049130.61131918
96HIF-1 signaling pathway_Homo sapiens_hsa040660.60936110
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59869867
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58692727
99Non-small cell lung cancer_Homo sapiens_hsa052230.58482892
100Chemical carcinogenesis_Homo sapiens_hsa052040.58141122
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.56586821
102Antigen processing and presentation_Homo sapiens_hsa046120.56008620
103Notch signaling pathway_Homo sapiens_hsa043300.55274486
104Pancreatic cancer_Homo sapiens_hsa052120.55119944
105Collecting duct acid secretion_Homo sapiens_hsa049660.54929575
106Glycerolipid metabolism_Homo sapiens_hsa005610.54714446
107Asthma_Homo sapiens_hsa053100.54039138
108Dorso-ventral axis formation_Homo sapiens_hsa043200.53136493
109Mineral absorption_Homo sapiens_hsa049780.53079626
110Endometrial cancer_Homo sapiens_hsa052130.52820742
111mTOR signaling pathway_Homo sapiens_hsa041500.52030143
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51995251
113GnRH signaling pathway_Homo sapiens_hsa049120.51953483
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51338769
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.50938275
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50935556
117Galactose metabolism_Homo sapiens_hsa000520.50120043
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49778660
119Legionellosis_Homo sapiens_hsa051340.49551320
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.49080573
121Renin-angiotensin system_Homo sapiens_hsa046140.48868988
122Pentose phosphate pathway_Homo sapiens_hsa000300.47819888
123Adherens junction_Homo sapiens_hsa045200.47323085
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47271979
125Protein digestion and absorption_Homo sapiens_hsa049740.47004773
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46468863
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46439326
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.46387956
129TNF signaling pathway_Homo sapiens_hsa046680.44678292
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44105535
131Tyrosine metabolism_Homo sapiens_hsa003500.43784384
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.43031017
133Fructose and mannose metabolism_Homo sapiens_hsa000510.42497307
134Rheumatoid arthritis_Homo sapiens_hsa053230.41840868
135Prostate cancer_Homo sapiens_hsa052150.41295593
136AMPK signaling pathway_Homo sapiens_hsa041520.41043237
137Insulin signaling pathway_Homo sapiens_hsa049100.40966068
138Type I diabetes mellitus_Homo sapiens_hsa049400.40773208
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39737453
140Endocytosis_Homo sapiens_hsa041440.38944029
141Carbon metabolism_Homo sapiens_hsa012000.37535864
142Vibrio cholerae infection_Homo sapiens_hsa051100.37368709
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.37172269
144Vitamin digestion and absorption_Homo sapiens_hsa049770.37005274
145Platelet activation_Homo sapiens_hsa046110.36923797
146Bladder cancer_Homo sapiens_hsa052190.35979620
147Pyruvate metabolism_Homo sapiens_hsa006200.35864692
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34529391

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »