GOLGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.87215094
2cellular extravasation (GO:0045123)5.36936441
3piRNA metabolic process (GO:0034587)4.53614462
4fat-soluble vitamin biosynthetic process (GO:0042362)4.34940514
5positive regulation of dendritic spine morphogenesis (GO:0061003)4.33392912
6histone H3-K4 trimethylation (GO:0080182)4.04290755
7mannose metabolic process (GO:0006013)3.73523968
8histone H3-K9 demethylation (GO:0033169)3.57898458
9carnitine transmembrane transport (GO:1902603)3.46598093
10DNA methylation involved in gamete generation (GO:0043046)3.43722613
11positive regulation of extracellular matrix organization (GO:1903055)3.31687704
12amino-acid betaine transport (GO:0015838)3.29857786
13carnitine transport (GO:0015879)3.29857786
14cyclic nucleotide catabolic process (GO:0009214)3.26732613
15cAMP catabolic process (GO:0006198)3.26175207
16histone H3-K36 demethylation (GO:0070544)3.23439187
17peptidyl-lysine trimethylation (GO:0018023)3.22327193
18exocrine pancreas development (GO:0031017)3.18462560
19ER overload response (GO:0006983)3.15079200
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12383044
21intestinal cholesterol absorption (GO:0030299)3.11421011
22regulation of clathrin-mediated endocytosis (GO:2000369)3.08234789
23auditory behavior (GO:0031223)3.05373697
24relaxation of cardiac muscle (GO:0055119)3.01224299
25regulation of beta-amyloid formation (GO:1902003)2.98082196
26phospholipid dephosphorylation (GO:0046839)2.97774403
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.97326850
28microglial cell activation (GO:0001774)2.96366807
29COPI coating of Golgi vesicle (GO:0048205)2.95423700
30Golgi transport vesicle coating (GO:0048200)2.95423700
31negative regulation of complement activation (GO:0045916)2.94285598
32negative regulation of protein activation cascade (GO:2000258)2.93868777
33regulation of protein kinase A signaling (GO:0010738)2.93305099
34negative regulation of interleukin-8 production (GO:0032717)2.93241643
35detection of molecule of bacterial origin (GO:0032490)2.88747910
36COPII vesicle coating (GO:0048208)2.87402068
37Golgi to plasma membrane protein transport (GO:0043001)2.86617774
38histone deubiquitination (GO:0016578)2.86164432
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.85518708
40phosphatidylinositol dephosphorylation (GO:0046856)2.85277119
41mechanosensory behavior (GO:0007638)2.84360443
42astrocyte differentiation (GO:0048708)2.84344196
43positive regulation of cellular amide metabolic process (GO:0034250)2.83520793
44regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81684787
45eye photoreceptor cell differentiation (GO:0001754)2.77687614
46photoreceptor cell differentiation (GO:0046530)2.77687614
47negative regulation of granulocyte differentiation (GO:0030853)2.77436654
48interkinetic nuclear migration (GO:0022027)2.76258357
49Golgi to endosome transport (GO:0006895)2.76176200
50cellular response to ethanol (GO:0071361)2.74413175
51response to auditory stimulus (GO:0010996)2.74318629
52positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.73774679
53* establishment of protein localization to Golgi (GO:0072600)2.73706086
54* protein targeting to Golgi (GO:0000042)2.72868674
55Golgi to plasma membrane transport (GO:0006893)2.71291940
56negative regulation of humoral immune response (GO:0002921)2.70156612
57alanine transport (GO:0032328)2.69082549
58membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67193277
59regulation of dendritic spine morphogenesis (GO:0061001)2.66466732
60positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66156402
61very-low-density lipoprotein particle assembly (GO:0034379)2.65506182
62neutrophil mediated immunity (GO:0002446)2.63415882
63negative regulation of erythrocyte differentiation (GO:0045647)2.61531289
64synaptic vesicle maturation (GO:0016188)2.61456787
65hypotonic response (GO:0006971)2.60162212
66regulation of ARF GTPase activity (GO:0032312)2.59018148
67nucleotide transmembrane transport (GO:1901679)2.58437785
68long-term synaptic potentiation (GO:0060291)2.56950383
69cellular potassium ion homeostasis (GO:0030007)2.56572172
70positive regulation of gamma-delta T cell activation (GO:0046645)2.56229086
71regulation of histone H3-K27 methylation (GO:0061085)2.56076357
72regulation of synaptic vesicle exocytosis (GO:2000300)2.55618716
73peptidyl-tyrosine autophosphorylation (GO:0038083)2.55045279
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54686045
75locomotory exploration behavior (GO:0035641)2.54040966
76synaptonemal complex assembly (GO:0007130)2.53778065
77maintenance of gastrointestinal epithelium (GO:0030277)2.52590524
78embryonic process involved in female pregnancy (GO:0060136)2.50479814
79detection of calcium ion (GO:0005513)2.49975302
80neuron cell-cell adhesion (GO:0007158)2.49657493
81cAMP metabolic process (GO:0046058)2.48936314
82dendrite morphogenesis (GO:0048813)2.47869979
83histone lysine demethylation (GO:0070076)2.47616658
84sphingosine metabolic process (GO:0006670)2.46745827
85regulation of endothelial cell chemotaxis (GO:2001026)2.46591712
86cholesterol efflux (GO:0033344)2.45686661
87lactate metabolic process (GO:0006089)2.45646241
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45594893
89positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.44990191
90skeletal muscle adaptation (GO:0043501)2.44950973
91intestinal absorption (GO:0050892)2.44834742
92macroautophagy (GO:0016236)2.44792179
93presynaptic membrane assembly (GO:0097105)2.44012829
94synaptic vesicle exocytosis (GO:0016079)2.43902427
95vitamin transmembrane transport (GO:0035461)2.43328210
96membrane repolarization during action potential (GO:0086011)2.42570143
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41644083
98innervation (GO:0060384)2.41079397
99muscle atrophy (GO:0014889)2.40216662
100startle response (GO:0001964)2.40045199
101detection of light stimulus involved in sensory perception (GO:0050962)2.39993987
102detection of light stimulus involved in visual perception (GO:0050908)2.39993987
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.39985132
104auditory receptor cell differentiation (GO:0042491)2.39608909
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.39562241
106regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.39036476
107striated muscle atrophy (GO:0014891)2.37551944
108quaternary ammonium group transport (GO:0015697)2.37299658
109regulation of interleukin-8 biosynthetic process (GO:0045414)2.36968337
110activation of protein kinase A activity (GO:0034199)2.36732679
111regulation of complement activation (GO:0030449)2.36536079
112positive regulation of dendritic spine development (GO:0060999)2.35787964
113Golgi organization (GO:0007030)2.35331464
114regulation of protein activation cascade (GO:2000257)2.34836513
115vesicle coating (GO:0006901)2.34270051
116* retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33199243
117histone demethylation (GO:0016577)2.33039146
118positive regulation by symbiont of host defense response (GO:0052509)2.32314880
119modulation by symbiont of host defense response (GO:0052031)2.32314880
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32314880
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32314880
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.32314880
123modulation by symbiont of host immune response (GO:0052553)2.32314880
124carnitine shuttle (GO:0006853)2.32109853
125positive regulation of potassium ion transport (GO:0043268)2.31952846
126regulation of gamma-delta T cell activation (GO:0046643)2.31685429
127protein localization to synapse (GO:0035418)2.30984779
128macrophage activation (GO:0042116)2.30492104
129regulation of skeletal muscle contraction (GO:0014819)2.29854898
130regulation of amyloid precursor protein catabolic process (GO:1902991)2.29592078
131lysosomal transport (GO:0007041)2.28969385
132myeloid leukocyte mediated immunity (GO:0002444)2.28253833
133neurotransmitter-gated ion channel clustering (GO:0072578)2.27297195
134regulation of synaptic vesicle transport (GO:1902803)2.27253535
135plasma lipoprotein particle assembly (GO:0034377)2.26773645
136regulation of extracellular matrix organization (GO:1903053)2.26501762
137striatum development (GO:0021756)2.26415773
138sprouting angiogenesis (GO:0002040)2.26266698
139fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.26252772
140embryonic camera-type eye morphogenesis (GO:0048596)2.25959309
141response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.25748658
142cerebral cortex radially oriented cell migration (GO:0021799)2.25433879
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24892256
144regulation of establishment or maintenance of cell polarity (GO:0032878)2.24459174
145import into cell (GO:0098657)2.24441754
146female mating behavior (GO:0060180)2.24359560
147* intra-Golgi vesicle-mediated transport (GO:0006891)2.24274315
148vocalization behavior (GO:0071625)2.24273615
149early endosome to late endosome transport (GO:0045022)2.23968014
150membrane depolarization during action potential (GO:0086010)2.23545475
151vacuolar transport (GO:0007034)2.23519247
152transcytosis (GO:0045056)2.23516212
153meiotic chromosome segregation (GO:0045132)2.23330737
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23328784
155cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.23280659
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.22935401
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.22935401
158growth hormone receptor signaling pathway (GO:0060396)2.22416271
159vesicle transport along microtubule (GO:0047496)2.22359431
160axonal fasciculation (GO:0007413)2.22223646
161protein localization to cilium (GO:0061512)2.21818666
162calcium ion import (GO:0070509)2.21767998
163glutamate secretion (GO:0014047)2.21579408
164regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.20971726
165detection of external biotic stimulus (GO:0098581)2.20847574
166diacylglycerol metabolic process (GO:0046339)2.20572566
167diol metabolic process (GO:0034311)2.19496500
168regulation of heart rate by cardiac conduction (GO:0086091)2.19491615
169negative regulation of glial cell proliferation (GO:0060253)2.19473891
170killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.19084384
171disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.19084384
172L-amino acid import (GO:0043092)2.17618408
173retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.17589300
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.17523981
175negative regulation of neurotransmitter secretion (GO:0046929)2.16595495
176heart trabecula formation (GO:0060347)2.16420367
177mitochondrion distribution (GO:0048311)2.16188218
178regulation of glycogen (starch) synthase activity (GO:2000465)2.15798586
179regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.15243362
180neurotransmitter secretion (GO:0007269)2.14866120
181cerebellar granule cell differentiation (GO:0021707)2.14421038
182neuron recognition (GO:0008038)2.14292557
183relaxation of muscle (GO:0090075)2.14152840
184negative regulation of endothelial cell apoptotic process (GO:2000352)2.11655128
185cilium or flagellum-dependent cell motility (GO:0001539)2.11565007
186calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.11395945
187membrane repolarization (GO:0086009)2.11347085
188axoneme assembly (GO:0035082)2.09419559
189regulation of potassium ion transmembrane transport (GO:1901379)2.08820646
190cAMP-mediated signaling (GO:0019933)2.07442724
191response to epinephrine (GO:0071871)2.07158615
192presynaptic membrane organization (GO:0097090)2.07097723
193vascular endothelial growth factor signaling pathway (GO:0038084)2.06868629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.41936060
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05036438
3EZH2_22144423_ChIP-Seq_EOC_Human2.79624751
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.36974984
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28873236
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23753215
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.19284140
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13466590
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11914621
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99730480
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.98723116
12VDR_21846776_ChIP-Seq_THP-1_Human1.98360354
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.98017522
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.95979840
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95761379
16LXR_22158963_ChIP-Seq_LIVER_Mouse1.94848876
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.93659453
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89995337
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89802035
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86864001
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86746149
22* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86104050
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85206373
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84866011
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81694905
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80662468
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79514548
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.78742161
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78511024
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75870129
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75287731
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74944537
33SMAD4_21799915_ChIP-Seq_A2780_Human1.74375667
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74064431
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73264098
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72144255
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70476738
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.68074700
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67235194
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.65377330
41TAF15_26573619_Chip-Seq_HEK293_Human1.64627905
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63174746
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62752556
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61899721
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.61627535
46SPI1_23127762_ChIP-Seq_K562_Human1.61598897
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61552984
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61552984
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61448888
50* DROSHA_22980978_ChIP-Seq_HELA_Human1.61019599
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60190280
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.59804261
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58470938
54IGF1R_20145208_ChIP-Seq_DFB_Human1.56942593
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56731960
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55863638
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55401102
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.54249054
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54151925
60REST_21632747_ChIP-Seq_MESCs_Mouse1.52899444
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52823918
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.51580061
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51158895
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50555157
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49499366
66AR_21572438_ChIP-Seq_LNCaP_Human1.48514882
67P300_19829295_ChIP-Seq_ESCs_Human1.48362960
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46806905
69AR_25329375_ChIP-Seq_VCAP_Human1.45839778
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44763079
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.43964424
72VDR_24763502_ChIP-Seq_THP-1_Human1.43237766
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.43228425
74TCF4_23295773_ChIP-Seq_U87_Human1.42976843
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.42784783
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41873605
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.41649157
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40545647
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39353258
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39313757
81STAT3_23295773_ChIP-Seq_U87_Human1.38590770
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38323478
83* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37358204
84SCL_19346495_ChIP-Seq_HPC-7_Human1.35419530
85ER_23166858_ChIP-Seq_MCF-7_Human1.35173317
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34588334
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34429250
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34402888
89ZNF274_21170338_ChIP-Seq_K562_Hela1.32934449
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32867174
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32647029
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32327375
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31465803
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31330427
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30494228
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30362878
97VDR_24787735_ChIP-Seq_THP-1_Human1.30354374
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.29577357
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26976480
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26221707
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.25888331
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25251429
103* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25151727
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.24546333
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24379483
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23313480
107BCAT_22108803_ChIP-Seq_LS180_Human1.22123455
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21693403
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.21464752
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21374055
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21374055
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20026251
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19891149
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19331627
115FUS_26573619_Chip-Seq_HEK293_Human1.18940504
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18339474
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17879832
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17207800
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16334638
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16334638
121AHR_22903824_ChIP-Seq_MCF-7_Human1.15694149
122TCF7_22412390_ChIP-Seq_EML_Mouse1.13255720
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13050864
124* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12658851
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12312540
126RUNX2_22187159_ChIP-Seq_PCA_Human1.12180720
127P53_22387025_ChIP-Seq_ESCs_Mouse1.11600641
128* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11570580
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11035705
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10437015
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10173830
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10173830
133* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09841596
134* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09603633
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09427108
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08750982
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06784071
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06452178
139CBP_20019798_ChIP-Seq_JUKART_Human1.06357937
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06357937
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06284309
142KDM2B_26808549_Chip-Seq_REH_Human1.06101655
143FLI1_27457419_Chip-Seq_LIVER_Mouse1.06041644
144PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05877038
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05614640
146TBX20_22080862_ChIP-Seq_HEART_Mouse1.05182711
147TBX20_22328084_ChIP-Seq_HEART_Mouse1.05182711
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04572787
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04251542
150RNF2_27304074_Chip-Seq_NSC_Mouse1.03720058
151TP53_16413492_ChIP-PET_HCT116_Human1.03648049
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03294749
153SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02801308
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02737239
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02199807
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01977385
157TP53_18474530_ChIP-ChIP_U2OS_Human1.01885763
158FOXA1_25552417_ChIP-Seq_VCAP_Human1.01683628
159REST_18959480_ChIP-ChIP_MESCs_Mouse1.01333008
160CMYC_18555785_Chip-Seq_ESCs_Mouse1.00809515
161GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00409277
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99973141
163SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99917869
164GATA2_19941826_ChIP-Seq_K562_Human0.99739947
165AR_19668381_ChIP-Seq_PC3_Human0.99136490
166TFEB_21752829_ChIP-Seq_HELA_Human0.98576254
167MAF_26560356_Chip-Seq_TH1_Human0.98483388
168GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98188786
169* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97876138
170RUNX_20019798_ChIP-Seq_JUKART_Human0.97133322
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96695953
172* KLF5_25053715_ChIP-Seq_YYC3_Human0.96453765
173* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95350444
174P300_18555785_Chip-Seq_ESCs_Mouse0.95214321
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94428895
176E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94160562
177AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94123900
178FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93817279
179STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92483408
180KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92367768
181* SPI1_23547873_ChIP-Seq_NB4_Human0.92325914
182ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92234883
183ESR1_21235772_ChIP-Seq_MCF-7_Human0.92104528
184MYB_26560356_Chip-Seq_TH1_Human0.91359933
185SMC4_20622854_ChIP-Seq_HELA_Human0.90882281
186MAF_26560356_Chip-Seq_TH2_Human0.90573599
187GATA6_25053715_ChIP-Seq_YYC3_Human0.90438503
188KDM2B_26808549_Chip-Seq_K562_Human0.89587154
189BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88801309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.95419690
2MP0003172_abnormal_lysosome_physiology3.17241656
3MP0009780_abnormal_chondrocyte_physiolo3.05027015
4MP0005058_abnormal_lysosome_morphology2.94012711
5MP0008260_abnormal_autophagy2.68387216
6MP0003950_abnormal_plasma_membrane2.51321768
7MP0004147_increased_porphyrin_level2.51291399
8MP0005365_abnormal_bile_salt2.45488672
9MP0005646_abnormal_pituitary_gland2.43159344
10MP0010386_abnormal_urinary_bladder2.34345580
11MP0003880_abnormal_central_pattern2.23011644
12MP0004859_abnormal_synaptic_plasticity2.16947346
13MP0005257_abnormal_intraocular_pressure2.16764671
14MP0009840_abnormal_foam_cell2.16069115
15MP0005551_abnormal_eye_electrophysiolog2.16020027
16MP0002822_catalepsy2.14108276
17MP0004043_abnormal_pH_regulation2.13856049
18MP0004270_analgesia2.10277130
19MP0003656_abnormal_erythrocyte_physiolo2.01318935
20MP0003787_abnormal_imprinting2.00750507
21MP0005083_abnormal_biliary_tract1.99941320
22MP0003191_abnormal_cellular_cholesterol1.99798508
23MP0003635_abnormal_synaptic_transmissio1.98965847
24MP0001486_abnormal_startle_reflex1.93066653
25MP0001968_abnormal_touch/_nociception1.90957183
26MP0003183_abnormal_peptide_metabolism1.89899997
27MP0005076_abnormal_cell_differentiation1.86356007
28MP0002734_abnormal_mechanical_nocicepti1.84978896
29MP0002736_abnormal_nociception_after1.82499257
30MP0005084_abnormal_gallbladder_morpholo1.76941975
31MP0002876_abnormal_thyroid_physiology1.71327896
32MP0002638_abnormal_pupillary_reflex1.70861387
33MP0001666_abnormal_nutrient_absorption1.70715093
34MP0002067_abnormal_sensory_capabilities1.70010360
35MP0005085_abnormal_gallbladder_physiolo1.66746623
36MP0003300_gastrointestinal_ulcer1.65713984
37MP0001984_abnormal_olfaction1.65301019
38MP0003690_abnormal_glial_cell1.64624486
39MP0002063_abnormal_learning/memory/cond1.62314282
40MP0009745_abnormal_behavioral_response1.60717318
41MP0009046_muscle_twitch1.59025033
42MP0000013_abnormal_adipose_tissue1.56493244
43MP0002009_preneoplasia1.55098553
44MP0002064_seizures1.52587479
45MP0000015_abnormal_ear_pigmentation1.50764459
46MP0002090_abnormal_vision1.50602451
47MP0000003_abnormal_adipose_tissue1.49585314
48MP0001958_emphysema1.47081653
49MP0002557_abnormal_social/conspecific_i1.46807710
50MP0002572_abnormal_emotion/affect_behav1.46715550
51MP0006072_abnormal_retinal_apoptosis1.45411294
52MP0003303_peritoneal_inflammation1.45336123
53MP0002272_abnormal_nervous_system1.45170858
54MP0004808_abnormal_hematopoietic_stem1.43642841
55MP0001188_hyperpigmentation1.42962875
56MP0010234_abnormal_vibrissa_follicle1.41919706
57MP0005410_abnormal_fertilization1.41693825
58MP0002735_abnormal_chemical_nociception1.40361249
59MP0005423_abnormal_somatic_nervous1.38325495
60MP0003252_abnormal_bile_duct1.36913731
61MP0008877_abnormal_DNA_methylation1.35908280
62MP0005409_darkened_coat_color1.35548338
63MP0005584_abnormal_enzyme/coenzyme_acti1.32541551
64MP0001502_abnormal_circadian_rhythm1.32018533
65MP0005645_abnormal_hypothalamus_physiol1.31023759
66MP0001440_abnormal_grooming_behavior1.30938770
67MP0002837_dystrophic_cardiac_calcinosis1.29101396
68MP0004264_abnormal_extraembryonic_tissu1.28356674
69MP0002184_abnormal_innervation1.28197680
70MP0000778_abnormal_nervous_system1.28165325
71MP0004924_abnormal_behavior1.27617944
72MP0005386_behavior/neurological_phenoty1.27617944
73MP0001873_stomach_inflammation1.26428919
74MP0003724_increased_susceptibility_to1.25894798
75MP0004883_abnormal_blood_vessel1.24883357
76MP0006138_congestive_heart_failure1.24711140
77MP0000631_abnormal_neuroendocrine_gland1.23245364
78MP0002971_abnormal_brown_adipose1.23145803
79MP0002269_muscular_atrophy1.22109200
80MP0003091_abnormal_cell_migration1.20213114
81MP0009115_abnormal_fat_cell1.19724927
82MP0005379_endocrine/exocrine_gland_phen1.18119577
83MP0005360_urolithiasis1.17723848
84MP0001661_extended_life_span1.17633636
85MP0010678_abnormal_skin_adnexa1.16244801
86MP0002139_abnormal_hepatobiliary_system1.14966586
87MP0005220_abnormal_exocrine_pancreas1.14237891
88MP0005164_abnormal_response_to1.14198242
89MP0000569_abnormal_digit_pigmentation1.14038944
90MP0003436_decreased_susceptibility_to1.13807459
91MP0003122_maternal_imprinting1.13478169
92MP0002909_abnormal_adrenal_gland1.13062227
93MP0002229_neurodegeneration1.11735578
94MP0005375_adipose_tissue_phenotype1.11007711
95MP0002419_abnormal_innate_immunity1.10873973
96MP0000371_diluted_coat_color1.10663551
97MP0002118_abnormal_lipid_homeostasis1.09509391
98MP0008569_lethality_at_weaning1.07869811
99MP0003868_abnormal_feces_composition1.06635169
100MP0005253_abnormal_eye_physiology1.06616126
101MP0000427_abnormal_hair_cycle1.06321096
102MP0001970_abnormal_pain_threshold1.06320437
103MP0001664_abnormal_digestion1.05938366
104MP0001346_abnormal_lacrimal_gland1.05727958
105MP0004130_abnormal_muscle_cell1.04950896
106MP0002928_abnormal_bile_duct1.04493157
107MP0000383_abnormal_hair_follicle1.04360937
108MP0001177_atelectasis1.02632660
109MP0005167_abnormal_blood-brain_barrier1.02516982
110MP0003566_abnormal_cell_adhesion1.02383521
111MP0003879_abnormal_hair_cell1.01831857
112MP0003943_abnormal_hepatobiliary_system1.01380541
113MP0006276_abnormal_autonomic_nervous1.00559714
114MP0002089_abnormal_postnatal_growth/wei1.00393043
115MP0000609_abnormal_liver_physiology1.00111321
116MP0002733_abnormal_thermal_nociception0.99860924
117MP0000751_myopathy0.99855788
118MP0002693_abnormal_pancreas_physiology0.99700881
119MP0001299_abnormal_eye_distance/0.99536202
120MP0002896_abnormal_bone_mineralization0.99109032
121MP0005319_abnormal_enzyme/_coenzyme0.98704509
122MP0001485_abnormal_pinna_reflex0.98674579
123MP0001501_abnormal_sleep_pattern0.98015437
124MP0004036_abnormal_muscle_relaxation0.97439546
125MP0003705_abnormal_hypodermis_morpholog0.97095165
126MP0004484_altered_response_of0.96362030
127MP0008875_abnormal_xenobiotic_pharmacok0.96300150
128MP0004742_abnormal_vestibular_system0.95737617
129MP0003453_abnormal_keratinocyte_physiol0.95221327
130MP0001944_abnormal_pancreas_morphology0.94969926
131MP0002396_abnormal_hematopoietic_system0.93364193
132MP0005666_abnormal_adipose_tissue0.93127449
133MP0002882_abnormal_neuron_morphology0.91974507
134MP0009697_abnormal_copulation0.91351507
135MP0000566_synostosis0.90632240
136MP0002332_abnormal_exercise_endurance0.90532583
137MP0003633_abnormal_nervous_system0.89377474
138MP0002108_abnormal_muscle_morphology0.86682170
139MP0004084_abnormal_cardiac_muscle0.86542052
140MP0003045_fibrosis0.86379245
141MP0002069_abnormal_eating/drinking_beha0.86373663
142MP0000747_muscle_weakness0.85917041
143MP0006054_spinal_hemorrhage0.85678254
144MP0010329_abnormal_lipoprotein_level0.85606155
145MP0000767_abnormal_smooth_muscle0.85400154
146MP0004233_abnormal_muscle_weight0.85268395
147MP0004215_abnormal_myocardial_fiber0.85121787
148MP0001915_intracranial_hemorrhage0.84899433
149MP0000955_abnormal_spinal_cord0.84723334
150MP0005464_abnormal_platelet_physiology0.84051187
151MP0003631_nervous_system_phenotype0.83473014
152MP0001963_abnormal_hearing_physiology0.83086565
153MP0009384_cardiac_valve_regurgitation0.82560942
154MP0005023_abnormal_wound_healing0.82539511
155MP0004019_abnormal_vitamin_homeostasis0.82507821
156MP0002168_other_aberrant_phenotype0.82009502
157MP0005408_hypopigmentation0.81842861
158MP0005025_abnormal_response_to0.81458076
159MP0001529_abnormal_vocalization0.81307653
160MP0005171_absent_coat_pigmentation0.80406033
161MP0003329_amyloid_beta_deposits0.79737661
162MP0005330_cardiomyopathy0.79127469
163MP0004811_abnormal_neuron_physiology0.78974288
164MP0008469_abnormal_protein_level0.78528999
165MP0004087_abnormal_muscle_fiber0.75608259
166MP0005334_abnormal_fat_pad0.75263569
167MP0002078_abnormal_glucose_homeostasis0.75211686
168MP0002998_abnormal_bone_remodeling0.74831001
169MP0004381_abnormal_hair_follicle0.73604790
170MP0003195_calcinosis0.73590264
171MP0006082_CNS_inflammation0.71750660
172MP0005621_abnormal_cell_physiology0.71334501
173MP0005503_abnormal_tendon_morphology0.67992935
174MP0003221_abnormal_cardiomyocyte_apopto0.67559952
175MP0004134_abnormal_chest_morphology0.67064430

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.82456951
2Hypoplasia of the fovea (HP:0007750)4.66816099
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.66816099
4Albinism (HP:0001022)4.48721038
5Hyperinsulinemic hypoglycemia (HP:0000825)4.05106188
6Epileptic encephalopathy (HP:0200134)4.02138190
7Hyperventilation (HP:0002883)3.99909176
8Symptomatic seizures (HP:0011145)3.79123613
9Febrile seizures (HP:0002373)3.71951422
10Hypoglycemic seizures (HP:0002173)3.52013080
11Abnormality of the fovea (HP:0000493)3.51424812
12Abnormal rod and cone electroretinograms (HP:0008323)3.46786532
13Broad face (HP:0000283)3.38016559
14Central scotoma (HP:0000603)3.35563152
15Papillary thyroid carcinoma (HP:0002895)3.31216461
16Aplasia/Hypoplasia of the macula (HP:0008059)3.22358065
17Urinary glycosaminoglycan excretion (HP:0003541)3.20938712
18Mucopolysacchariduria (HP:0008155)3.20938712
19Absent/shortened dynein arms (HP:0200106)3.16860537
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.16860537
21Abnormal pancreas size (HP:0012094)3.07918086
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02853748
23Abnormality of polysaccharide metabolism (HP:0011012)3.02853748
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02853748
25Asymmetric septal hypertrophy (HP:0001670)2.92890827
26Aplasia/Hypoplasia affecting the retina (HP:0008061)2.91017741
27Deep venous thrombosis (HP:0002625)2.90413239
28Difficulty running (HP:0009046)2.90162832
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89685417
30Abnormality of macular pigmentation (HP:0008002)2.89315209
31Focal motor seizures (HP:0011153)2.82161983
32Blue irides (HP:0000635)2.80007298
33Gait imbalance (HP:0002141)2.71796105
34Medial flaring of the eyebrow (HP:0010747)2.71190689
35Epileptiform EEG discharges (HP:0011182)2.70010401
36EEG with generalized epileptiform discharges (HP:0011198)2.69570596
37Atonic seizures (HP:0010819)2.67983396
38Congenital primary aphakia (HP:0007707)2.64447203
39Hypoglycemic coma (HP:0001325)2.63380250
40Progressive hearing impairment (HP:0001730)2.63308302
41Congenital stationary night blindness (HP:0007642)2.61591318
42Hypsarrhythmia (HP:0002521)2.60721515
43Congenital sensorineural hearing impairment (HP:0008527)2.60208662
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59405817
45Glomerulonephritis (HP:0000099)2.59200413
46Subacute progressive viral hepatitis (HP:0006572)2.56721066
47Prolonged QT interval (HP:0001657)2.53991349
48Hypercholesterolemia (HP:0003124)2.53047013
49Chronic hepatic failure (HP:0100626)2.52157145
50Dysostosis multiplex (HP:0000943)2.47687540
51Anxiety (HP:0000739)2.45839798
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45475549
53Recurrent gram-negative bacterial infections (HP:0005420)2.42261302
54Tetany (HP:0001281)2.40184522
55Hypothermia (HP:0002045)2.37947521
56Ketoacidosis (HP:0001993)2.36377907
57Focal seizures (HP:0007359)2.35903006
58Osteomalacia (HP:0002749)2.31977058
59Macroorchidism (HP:0000053)2.29314807
60Flat acetabular roof (HP:0003180)2.28912759
61Abnormal respiratory epithelium morphology (HP:0012253)2.28397469
62Abnormal respiratory motile cilium morphology (HP:0005938)2.28397469
63Cheilitis (HP:0100825)2.26960693
64Prolonged partial thromboplastin time (HP:0003645)2.26786462
65Abnormal respiratory motile cilium physiology (HP:0012261)2.26660731
66Hemiparesis (HP:0001269)2.26173167
67Exercise-induced myalgia (HP:0003738)2.25612673
68Nephrogenic diabetes insipidus (HP:0009806)2.23057738
69Heterotopia (HP:0002282)2.21891995
70Abnormal ciliary motility (HP:0012262)2.20746764
71Abnormality of the intrinsic pathway (HP:0010989)2.19533982
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19092245
73Hyperphosphatemia (HP:0002905)2.18484559
74Tubulointerstitial nephritis (HP:0001970)2.18219577
75Hypoplasia of the uterus (HP:0000013)2.18190279
76Coarse hair (HP:0002208)2.18152494
77Eczematoid dermatitis (HP:0000976)2.17061443
78Ventricular fibrillation (HP:0001663)2.15491373
79Complement deficiency (HP:0004431)2.11492369
80Agitation (HP:0000713)2.11308989
81Increased circulating renin level (HP:0000848)2.10843770
82Progressive cerebellar ataxia (HP:0002073)2.10294084
83Generalized hypopigmentation (HP:0007513)2.09747379
84Conjugated hyperbilirubinemia (HP:0002908)2.09552886
85Abnormal EKG (HP:0003115)2.07700124
86Bell-shaped thorax (HP:0001591)2.06613500
87Gaze-evoked nystagmus (HP:0000640)2.06348522
88Truncal ataxia (HP:0002078)2.05276039
89Truncus arteriosus (HP:0001660)2.04170983
90Papilledema (HP:0001085)2.03975875
91Cone-rod dystrophy (HP:0000548)2.03508089
92Drooling (HP:0002307)2.03118676
93Excessive salivation (HP:0003781)2.03118676
94Abnormality of the parathyroid morphology (HP:0011766)2.02084765
95Scotoma (HP:0000575)2.01341277
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.00301725
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00301725
98Poor coordination (HP:0002370)1.99581883
99Abnormality of fatty-acid metabolism (HP:0004359)1.99407239
100Abnormality of calcium-phosphate metabolism (HP:0100530)1.98769261
101Megalencephaly (HP:0001355)1.98512262
102Thin bony cortex (HP:0002753)1.97504293
103Nephronophthisis (HP:0000090)1.96517950
104Broad-based gait (HP:0002136)1.96489552
105Hand muscle atrophy (HP:0009130)1.94679757
106Vaginal atresia (HP:0000148)1.94239543
107Systemic lupus erythematosus (HP:0002725)1.94093921
108Loss of speech (HP:0002371)1.93912576
109Peritonitis (HP:0002586)1.93721752
110Aplasia/hypoplasia of the uterus (HP:0008684)1.93537918
111Syncope (HP:0001279)1.93005137
112Periodontitis (HP:0000704)1.92747931
113Genital tract atresia (HP:0001827)1.92040972
114Absence seizures (HP:0002121)1.90715916
115Specific learning disability (HP:0001328)1.90640546
116Pheochromocytoma (HP:0002666)1.90581782
117Insulin-resistant diabetes mellitus (HP:0000831)1.90277568
118Progressive inability to walk (HP:0002505)1.89052983
119Hyperthyroidism (HP:0000836)1.87103297
120Renal cortical cysts (HP:0000803)1.86853567
121Glucose intolerance (HP:0000833)1.86620789
122Cervical subluxation (HP:0003308)1.84539485
123Obstructive sleep apnea (HP:0002870)1.84375179
124Abnormality of glycolipid metabolism (HP:0010969)1.84230759
125Abnormality of liposaccharide metabolism (HP:0010968)1.84230759
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.84230759
127True hermaphroditism (HP:0010459)1.83305696
128Gingivitis (HP:0000230)1.83176852
129Peripheral hypomyelination (HP:0007182)1.83102045
130Increased CSF protein (HP:0002922)1.82065793
131Abnormality of the renal medulla (HP:0100957)1.81236131
132Hemorrhage of the eye (HP:0011885)1.79646309
133Spinal canal stenosis (HP:0003416)1.79023973
134Retinitis pigmentosa (HP:0000510)1.77785316
135Upper limb amyotrophy (HP:0009129)1.77701327
136Distal upper limb amyotrophy (HP:0007149)1.77701327
137Abnormality of complement system (HP:0005339)1.77574887
138Generalized tonic-clonic seizures (HP:0002069)1.77220209
139Tibial bowing (HP:0002982)1.76898514
140Decreased lacrimation (HP:0000633)1.76679042
141Deformed sella turcica (HP:0002681)1.75226762
142Hyperglycemia (HP:0003074)1.74443798
143Bony spicule pigmentary retinopathy (HP:0007737)1.74391537
144Slow saccadic eye movements (HP:0000514)1.73912378
145Hypoplastic nipples (HP:0002557)1.73785026
146Aplasia/Hypoplasia of the lens (HP:0008063)1.73699316
147Hypomagnesemia (HP:0002917)1.71301005
148Hip dysplasia (HP:0001385)1.69679803
149Abnormality of the renal cortex (HP:0011035)1.69630655
150Generalized aminoaciduria (HP:0002909)1.69397656
151Alacrima (HP:0000522)1.68347903
152Abnormal glucose tolerance (HP:0001952)1.68189416
153Impaired vibration sensation in the lower limbs (HP:0002166)1.67677663
154Pancreatic islet-cell hyperplasia (HP:0004510)1.67404210
155Abnormality of salivation (HP:0100755)1.67263501
156Abnormality of the common coagulation pathway (HP:0010990)1.67219105
157Decreased motor nerve conduction velocity (HP:0003431)1.66744130
158Severe short stature (HP:0003510)1.66531838
159Abnormality of the fingertips (HP:0001211)1.66018614
160Pigmentary retinal degeneration (HP:0001146)1.65569211
161Hypoplasia of dental enamel (HP:0006297)1.65172244
162Postaxial hand polydactyly (HP:0001162)1.64590067
163Absent eyebrow (HP:0002223)1.64546696
164Oligodactyly (hands) (HP:0001180)1.64444233
165Abolished electroretinogram (ERG) (HP:0000550)1.63805209
166Nuclear cataract (HP:0100018)1.63340955
167Flared iliac wings (HP:0002869)1.63230058
168Abnormality of macrophages (HP:0004311)1.63012877
169Ovoid vertebral bodies (HP:0003300)1.62714459
170Hyperkalemia (HP:0002153)1.62566985
171Lip pit (HP:0100267)1.61578089
172Increased IgE level (HP:0003212)1.61164914
173Hypertriglyceridemia (HP:0002155)1.60183230
174Protrusio acetabuli (HP:0003179)1.59400065
175Cupped ribs (HP:0000887)1.58550904
176Abnormal hand bone ossification (HP:0010660)1.58548496
177Proximal tubulopathy (HP:0000114)1.57832357
178Abnormal ossification of hand bones (HP:0005921)1.57674657
179Laryngomalacia (HP:0001601)1.57568324
180Abnormality of the thoracic spine (HP:0100711)1.56793187
181Generalized hyperpigmentation (HP:0007440)1.53992388
182Bilateral sensorineural hearing impairment (HP:0008619)1.53753393
183Recurrent bacterial skin infections (HP:0005406)1.52635260
184Spondylolisthesis (HP:0003302)1.51124134
185Atelectasis (HP:0100750)1.50451371
186J-shaped sella turcica (HP:0002680)1.49979185
187Abnormality of carpal bone ossification (HP:0006257)1.49052427
188Joint hemorrhage (HP:0005261)1.48828378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.49161981
2INSRR3.69785107
3CDK123.49693292
4CASK3.16872012
5ERN13.16533401
6BRD42.81040305
7AKT32.62595492
8BLK2.52049584
9EPHB12.43892777
10GRK12.43588179
11CAMK1D2.39057531
12CAMK1G2.24097118
13SGK22.06978649
14RIPK42.05727218
15MAP3K22.01026389
16EPHA42.00567883
17NTRK31.96229128
18ZAP701.94940895
19SGK2231.88341353
20SGK4941.88341353
21TYK21.80208055
22NEK91.69864452
23PTK2B1.67721507
24TRIB31.60685640
25FGFR31.60213752
26SGK31.59463033
27MAP3K41.58839532
28TEC1.56836930
29NUAK11.53003974
30FGFR41.52493889
31IRAK41.52193552
32MAP2K71.50098470
33LMTK21.45418087
34PIK3CA1.44907315
35KSR21.39314305
36FRK1.38086813
37MARK21.32551762
38MAP3K11.30203669
39MAP2K31.28215190
40EPHA31.27330287
41IRAK31.24155292
42TNIK1.23450990
43BMX1.22731929
44MAPK131.20888643
45MAPK71.19874923
46PHKG11.15554355
47PHKG21.15554355
48PRKCE1.14898312
49CSF1R1.10080644
50PKN21.09788740
51PRKD21.09157285
52CSK1.06322062
53MET1.05891095
54MAP3K71.00617121
55MAP3K61.00288245
56MTOR0.98929428
57LATS10.98491518
58FER0.97733039
59MAPK120.96458968
60NEK60.95339830
61PINK10.92934328
62RPS6KB20.92154593
63STK390.91778022
64WNK40.91411300
65RIPK10.90461497
66PAK30.90399522
67RPS6KA20.89815449
68NTRK20.88311311
69SIK10.87027535
70PIK3CG0.86347235
71PDGFRA0.86145793
72PDK30.85821127
73PDK40.85821127
74MAPK150.85578043
75PDGFRB0.85365805
76EEF2K0.84118516
77TAOK30.83214332
78MARK10.82761508
79SGK10.82375559
80WNK10.80158925
81PTK20.79500558
82DYRK1B0.79473298
83MAPKAPK30.78484751
84PRKCG0.77928929
85YES10.76767636
86RAF10.75001223
87TTN0.74319822
88BMPR20.73424976
89MAP3K30.73302007
90PDK20.70932167
91PRKD30.69759681
92IRAK10.69661349
93ERBB30.67891832
94TNK20.67768169
95KSR10.66763964
96IKBKE0.66450733
97PRPF4B0.66335449
98JAK20.65924727
99CDK50.64936353
100BCR0.62935386
101MST1R0.62503284
102BMPR1B0.62405494
103MAPK100.61928808
104PRKD10.61494473
105MOS0.61114597
106WNK30.59625463
107CAMK40.59205461
108TRPM70.58992320
109PRKAA10.58958465
110ARAF0.58730612
111PRKCH0.56688570
112OXSR10.56296324
113TAOK10.55999715
114MINK10.55740636
115CDC42BPA0.54772264
116GRK60.54738878
117PTK60.54629973
118MAP2K40.53448153
119DYRK1A0.52800255
120CAMK2A0.52007814
121SIK20.51206752
122CAMK10.50283766
123TBK10.49587904
124PDK10.49144501
125CAMK2D0.47833770
126PRKAA20.47498340
127PRKCQ0.47242944
128IRAK20.47221514
129CAMK2B0.47094936
130CDK30.46040496
131PKN10.46026276
132HIPK20.45066406
133OBSCN0.42795143
134NTRK10.42721904
135RPS6KC10.41709138
136RPS6KL10.41709138
137MAPK110.39985760
138ICK0.39851562
139GRK70.39444588
140RET0.38482755
141DAPK20.38318330
142ZAK0.38262947
143MAPKAPK20.38155830
144JAK10.37734026
145MAP2K10.37713109
146MAPK80.37645823
147TSSK60.37645229
148STK380.37610405
149PLK20.37462734
150RPS6KA30.36537652
151PRKG10.36381986
152RPS6KB10.36347002
153PRKCB0.35459133
154DMPK0.35148160
155PRKCZ0.34454728
156PRKACA0.34371465
157MAP2K20.34030246
158GRK50.32046581
159ROCK10.31050425
160PDPK10.30998003
161CAMKK20.29730973
162MUSK0.29447061

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.06407495
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.71750790
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.47973571
4Insulin secretion_Homo sapiens_hsa049112.35833665
5Morphine addiction_Homo sapiens_hsa050322.12840449
6GABAergic synapse_Homo sapiens_hsa047271.95464186
7Nicotine addiction_Homo sapiens_hsa050331.92672132
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89604388
9Olfactory transduction_Homo sapiens_hsa047401.89123317
10Pancreatic secretion_Homo sapiens_hsa049721.81720132
11Complement and coagulation cascades_Homo sapiens_hsa046101.77698580
12Circadian entrainment_Homo sapiens_hsa047131.77002871
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75258540
14Taste transduction_Homo sapiens_hsa047421.73398659
15mTOR signaling pathway_Homo sapiens_hsa041501.61989413
16Glutamatergic synapse_Homo sapiens_hsa047241.61978405
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59572331
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58763327
19Salivary secretion_Homo sapiens_hsa049701.57877577
20Bile secretion_Homo sapiens_hsa049761.55236316
21Gastric acid secretion_Homo sapiens_hsa049711.53475991
22Cholinergic synapse_Homo sapiens_hsa047251.47678120
23Phototransduction_Homo sapiens_hsa047441.46887056
24Sulfur metabolism_Homo sapiens_hsa009201.46614817
25Lysine degradation_Homo sapiens_hsa003101.43599082
26Synaptic vesicle cycle_Homo sapiens_hsa047211.42588910
27Renin secretion_Homo sapiens_hsa049241.41510101
28Vitamin digestion and absorption_Homo sapiens_hsa049771.40716866
29Protein export_Homo sapiens_hsa030601.39878189
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36985471
31Endometrial cancer_Homo sapiens_hsa052131.29983379
32Notch signaling pathway_Homo sapiens_hsa043301.27445059
33ABC transporters_Homo sapiens_hsa020101.27437124
34Staphylococcus aureus infection_Homo sapiens_hsa051501.25298076
35Serotonergic synapse_Homo sapiens_hsa047261.25121450
36Prolactin signaling pathway_Homo sapiens_hsa049171.23015009
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22167296
38Dopaminergic synapse_Homo sapiens_hsa047281.21597569
39Osteoclast differentiation_Homo sapiens_hsa043801.21496756
40Histidine metabolism_Homo sapiens_hsa003401.20445074
41B cell receptor signaling pathway_Homo sapiens_hsa046621.19933622
42Amphetamine addiction_Homo sapiens_hsa050311.19676502
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19212892
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17706632
45Acute myeloid leukemia_Homo sapiens_hsa052211.17499043
46Insulin signaling pathway_Homo sapiens_hsa049101.17141295
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15306952
48Non-small cell lung cancer_Homo sapiens_hsa052231.14071394
49Lysosome_Homo sapiens_hsa041421.12619466
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11236498
51Thyroid hormone synthesis_Homo sapiens_hsa049181.11183518
52Propanoate metabolism_Homo sapiens_hsa006401.08124481
53Chronic myeloid leukemia_Homo sapiens_hsa052201.07566608
54Glucagon signaling pathway_Homo sapiens_hsa049221.06886998
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06636439
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05610063
57Type II diabetes mellitus_Homo sapiens_hsa049301.05386592
58Calcium signaling pathway_Homo sapiens_hsa040201.05002299
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04355231
60Ovarian steroidogenesis_Homo sapiens_hsa049131.03852971
61Sphingolipid metabolism_Homo sapiens_hsa006001.03285233
62Mineral absorption_Homo sapiens_hsa049781.02835681
63Long-term potentiation_Homo sapiens_hsa047201.01477417
64Butanoate metabolism_Homo sapiens_hsa006501.01062823
65Regulation of autophagy_Homo sapiens_hsa041401.00657685
66Dorso-ventral axis formation_Homo sapiens_hsa043201.00194372
67Vibrio cholerae infection_Homo sapiens_hsa051101.00056549
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99221158
69Collecting duct acid secretion_Homo sapiens_hsa049660.98871784
70Rheumatoid arthritis_Homo sapiens_hsa053230.98591625
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97269630
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.96813524
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96580139
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96450554
75Phenylalanine metabolism_Homo sapiens_hsa003600.95424275
76Hepatitis C_Homo sapiens_hsa051600.95309341
77PPAR signaling pathway_Homo sapiens_hsa033200.94899391
78cAMP signaling pathway_Homo sapiens_hsa040240.94514867
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94504047
80Renal cell carcinoma_Homo sapiens_hsa052110.94381642
81Prion diseases_Homo sapiens_hsa050200.94003208
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93639188
83Cocaine addiction_Homo sapiens_hsa050300.93196356
84Amoebiasis_Homo sapiens_hsa051460.92595603
85AMPK signaling pathway_Homo sapiens_hsa041520.91699595
86ErbB signaling pathway_Homo sapiens_hsa040120.91000739
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90926302
88Fructose and mannose metabolism_Homo sapiens_hsa000510.90888589
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.89593136
90Circadian rhythm_Homo sapiens_hsa047100.88375696
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88170259
92Pancreatic cancer_Homo sapiens_hsa052120.88165249
93VEGF signaling pathway_Homo sapiens_hsa043700.86989723
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85946658
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.85820290
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85715121
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84975766
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.84045673
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83119788
100beta-Alanine metabolism_Homo sapiens_hsa004100.82565595
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.80097035
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.79190466
103Fat digestion and absorption_Homo sapiens_hsa049750.77685876
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77434205
105Protein digestion and absorption_Homo sapiens_hsa049740.76688214
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76668866
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74482839
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73799672
109Estrogen signaling pathway_Homo sapiens_hsa049150.73114507
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.72714466
111Oxytocin signaling pathway_Homo sapiens_hsa049210.71006021
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70922702
113Vitamin B6 metabolism_Homo sapiens_hsa007500.70343100
114Long-term depression_Homo sapiens_hsa047300.69792962
115Melanogenesis_Homo sapiens_hsa049160.69787662
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68358112
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.67368418
118FoxO signaling pathway_Homo sapiens_hsa040680.66523659
119GnRH signaling pathway_Homo sapiens_hsa049120.66465272
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66093190
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65917499
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65907123
123Tuberculosis_Homo sapiens_hsa051520.65738116
124Hepatitis B_Homo sapiens_hsa051610.65325886
125Dilated cardiomyopathy_Homo sapiens_hsa054140.64016241
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62416190
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61718739
128Fatty acid degradation_Homo sapiens_hsa000710.61172525
129TNF signaling pathway_Homo sapiens_hsa046680.60945538
130Fatty acid elongation_Homo sapiens_hsa000620.59779052
131Influenza A_Homo sapiens_hsa051640.59747092
132Glioma_Homo sapiens_hsa052140.59677528
133Endocytosis_Homo sapiens_hsa041440.58983033
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58942904
135Peroxisome_Homo sapiens_hsa041460.58256415
136Gap junction_Homo sapiens_hsa045400.58252272
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56730004
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56491260
139Leishmaniasis_Homo sapiens_hsa051400.56126056
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55694022
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55557382
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55313082
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.54618134
144Fatty acid metabolism_Homo sapiens_hsa012120.54202943
145Colorectal cancer_Homo sapiens_hsa052100.53606142
146Choline metabolism in cancer_Homo sapiens_hsa052310.52070837
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.51936007
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.51101899
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50468593
150Pertussis_Homo sapiens_hsa051330.50225806
151Tryptophan metabolism_Homo sapiens_hsa003800.50151063
152Focal adhesion_Homo sapiens_hsa045100.50007609
153Toxoplasmosis_Homo sapiens_hsa051450.49856305
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49346172
155Insulin resistance_Homo sapiens_hsa049310.49346023
156Starch and sucrose metabolism_Homo sapiens_hsa005000.48842579
157Axon guidance_Homo sapiens_hsa043600.46967180
158Phagosome_Homo sapiens_hsa041450.46207352
159Fatty acid biosynthesis_Homo sapiens_hsa000610.45377280
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44742214
161Prostate cancer_Homo sapiens_hsa052150.43579643
162Ras signaling pathway_Homo sapiens_hsa040140.43186532
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40976924
164Cardiac muscle contraction_Homo sapiens_hsa042600.40278311
165Inositol phosphate metabolism_Homo sapiens_hsa005620.37511376

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