GOLGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.63312535
2plasma membrane repair (GO:0001778)4.38745139
3collagen fibril organization (GO:0030199)3.70602044
4basement membrane organization (GO:0071711)3.62966010
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59075523
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.58007130
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.56070987
8endothelial cell chemotaxis (GO:0035767)3.53071824
9protein retention in ER lumen (GO:0006621)3.51616390
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47149237
11focal adhesion assembly (GO:0048041)3.45878743
12cell-substrate adherens junction assembly (GO:0007045)3.45878743
13negative regulation of potassium ion transmembrane transport (GO:1901380)3.44055035
14regulation of histone H3-K27 methylation (GO:0061085)3.38614646
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33813794
16vesicle coating (GO:0006901)3.31718379
17regulation of early endosome to late endosome transport (GO:2000641)3.27037001
18COPII vesicle coating (GO:0048208)3.23229669
19cell communication involved in cardiac conduction (GO:0086065)3.15539268
20protein heterotrimerization (GO:0070208)3.14700985
21sarcomere organization (GO:0045214)3.14163241
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11834666
23cell communication by electrical coupling (GO:0010644)3.10933249
24sodium ion export (GO:0071436)3.09598321
25cardiac myofibril assembly (GO:0055003)3.08427859
26Golgi transport vesicle coating (GO:0048200)3.07614739
27COPI coating of Golgi vesicle (GO:0048205)3.07614739
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04106625
29protein localization to endosome (GO:0036010)3.03507032
30activation of protein kinase A activity (GO:0034199)3.00704991
31regulation of extracellular matrix disassembly (GO:0010715)2.98959943
32semaphorin-plexin signaling pathway (GO:0071526)2.98469901
33negative regulation of cell size (GO:0045792)2.98405173
34carnitine shuttle (GO:0006853)2.92518238
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90463323
36insulin-like growth factor receptor signaling pathway (GO:0048009)2.82129914
37positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81209336
38positive regulation of blood vessel endothelial cell migration (GO:0043536)2.80808661
39endodermal cell differentiation (GO:0035987)2.79158022
40regulation of ARF protein signal transduction (GO:0032012)2.76209260
41mannose metabolic process (GO:0006013)2.75829935
42ventricular cardiac muscle cell action potential (GO:0086005)2.75671735
43vascular endothelial growth factor signaling pathway (GO:0038084)2.74486709
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.73850249
45atrioventricular valve morphogenesis (GO:0003181)2.72394922
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.72305840
47establishment of apical/basal cell polarity (GO:0035089)2.70569949
48iron ion import (GO:0097286)2.70091899
49cell adhesion mediated by integrin (GO:0033627)2.67667455
50collagen metabolic process (GO:0032963)2.67577250
51macroautophagy (GO:0016236)2.66668428
52sequestering of extracellular ligand from receptor (GO:0035581)2.64985129
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63898856
54fatty acid transmembrane transport (GO:1902001)2.63861044
55stress fiber assembly (GO:0043149)2.62987964
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60762798
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60369850
58regulation of p38MAPK cascade (GO:1900744)2.60072126
59myofibril assembly (GO:0030239)2.59270205
60collagen catabolic process (GO:0030574)2.58652543
61cardiac muscle contraction (GO:0060048)2.58053681
62protein targeting to Golgi (GO:0000042)2.57519817
63multicellular organismal macromolecule metabolic process (GO:0044259)2.53933925
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53622236
65positive regulation of glycogen biosynthetic process (GO:0045725)2.52691706
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52141053
67regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51775125
68regulation of fatty acid beta-oxidation (GO:0031998)2.51642169
69endocardial cushion development (GO:0003197)2.51085730
70positive regulation of nuclease activity (GO:0032075)2.50522454
71Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50120214
72glomerular basement membrane development (GO:0032836)2.48715058
73bone trabecula formation (GO:0060346)2.48596995
74relaxation of cardiac muscle (GO:0055119)2.47350776
75regulation of fatty acid oxidation (GO:0046320)2.47164481
76establishment of protein localization to Golgi (GO:0072600)2.47128408
77cellular response to unfolded protein (GO:0034620)2.46312862
78positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46111001
79cerebellar Purkinje cell layer development (GO:0021680)2.44060924
80layer formation in cerebral cortex (GO:0021819)2.43817177
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43751997
82actomyosin structure organization (GO:0031032)2.42927095
83carnitine transmembrane transport (GO:1902603)2.42162959
84multicellular organismal metabolic process (GO:0044236)2.41486360
85potassium ion import (GO:0010107)2.41128566
86regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40882565
87regulation of establishment of planar polarity (GO:0090175)2.40380466
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39929867
894-hydroxyproline metabolic process (GO:0019471)2.39565096
90kidney mesenchyme development (GO:0072074)2.39563168
91multicellular organismal catabolic process (GO:0044243)2.39353788
92eye morphogenesis (GO:0048592)2.39179373
93bundle of His cell to Purkinje myocyte communication (GO:0086069)2.37621009
94positive regulation of fatty acid beta-oxidation (GO:0032000)2.37473398
95synaptic vesicle maturation (GO:0016188)2.37366255
96embryonic eye morphogenesis (GO:0048048)2.36261413
97extracellular matrix disassembly (GO:0022617)2.36227665
98regulation of RNA export from nucleus (GO:0046831)2.35956293
99negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.35125731
100retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34877272
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34652977
102hemidesmosome assembly (GO:0031581)2.33616841
103apoptotic cell clearance (GO:0043277)2.33368183
104positive regulation of histone deacetylation (GO:0031065)2.32967513
105endocytic recycling (GO:0032456)2.32019772
106regulation of water loss via skin (GO:0033561)2.31740841
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.31201033
108regulation of axon extension involved in axon guidance (GO:0048841)2.30995945
109regulation of synapse structural plasticity (GO:0051823)2.30356103
110regulation of nucleobase-containing compound transport (GO:0032239)2.30293678
111cell-cell junction maintenance (GO:0045217)2.29520624
112endocrine hormone secretion (GO:0060986)2.29013758
113amino-acid betaine transport (GO:0015838)2.28757128
114carnitine transport (GO:0015879)2.28757128
115cell-substrate junction assembly (GO:0007044)2.28747915
116positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28595721
117cellular response to topologically incorrect protein (GO:0035967)2.28249062
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28226927
119branching involved in mammary gland duct morphogenesis (GO:0060444)2.28035320
120positive regulation of p38MAPK cascade (GO:1900745)2.28013337
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.27951588
122metanephric mesenchyme development (GO:0072075)2.27474796
123growth hormone secretion (GO:0030252)2.27389871
124protein hydroxylation (GO:0018126)2.27173806
125regulation of membrane repolarization (GO:0060306)2.26678871
126camera-type eye morphogenesis (GO:0048593)2.25558408
127polarized epithelial cell differentiation (GO:0030859)2.25486846
128sarcoplasmic reticulum calcium ion transport (GO:0070296)2.25206985
129positive regulation of osteoblast proliferation (GO:0033690)2.24958836
130coronary vasculature morphogenesis (GO:0060977)2.24609767
131establishment of nucleus localization (GO:0040023)2.24585597
132protein targeting to plasma membrane (GO:0072661)2.24581896
133chondrocyte development (GO:0002063)2.22872786
134negative regulation of fatty acid transport (GO:2000192)2.21822401
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21763265
136epithelial cell-cell adhesion (GO:0090136)2.21728358
137surfactant homeostasis (GO:0043129)2.20367478
138positive regulation of receptor recycling (GO:0001921)2.19878936
139regulation of cholesterol homeostasis (GO:2000188)2.18670809
140regulation of ARF GTPase activity (GO:0032312)2.18528309
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.18079895
142endoplasmic reticulum unfolded protein response (GO:0030968)2.17992270
143positive regulation of glycogen metabolic process (GO:0070875)2.17915601
144adherens junction assembly (GO:0034333)2.17846396
145peptidyl-lysine dimethylation (GO:0018027)2.17695157
146actin-myosin filament sliding (GO:0033275)2.16985074
147muscle filament sliding (GO:0030049)2.16985074
148peptidyl-proline hydroxylation (GO:0019511)2.16979791
149import into cell (GO:0098657)2.16765857
150regulation of clathrin-mediated endocytosis (GO:2000369)2.16453038
151low-density lipoprotein particle clearance (GO:0034383)2.16246748
152regulation of calcium ion transmembrane transport (GO:1903169)2.15768082
153regulation of calcium ion transmembrane transporter activity (GO:1901019)2.15768082
154negative regulation of adherens junction organization (GO:1903392)2.15422509
155negative regulation of focal adhesion assembly (GO:0051895)2.15422509
156negative regulation of cell junction assembly (GO:1901889)2.15422509
157regulation of endothelial cell chemotaxis (GO:2001026)2.15118292
158locomotory exploration behavior (GO:0035641)2.14728995
159regulation of nuclease activity (GO:0032069)2.14664146
160regulation of glucose import in response to insulin stimulus (GO:2001273)2.14136333
161creatine metabolic process (GO:0006600)2.13539202
162positive regulation of fatty acid oxidation (GO:0046321)2.13430383
163negative regulation of potassium ion transport (GO:0043267)2.12847859
164skin morphogenesis (GO:0043589)2.11093829
165cellular potassium ion homeostasis (GO:0030007)2.10673803
166ER-nucleus signaling pathway (GO:0006984)2.10354209
167regulation of skeletal muscle contraction (GO:0014819)2.08569507
168positive regulation of fibroblast migration (GO:0010763)2.08227948
169negative regulation of nucleotide catabolic process (GO:0030812)2.08199035
1702-oxoglutarate metabolic process (GO:0006103)2.07779520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20775178
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06515675
3HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03937768
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99703639
5EZH2_22144423_ChIP-Seq_EOC_Human1.99567731
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98989916
7DROSHA_22980978_ChIP-Seq_HELA_Human1.93340231
8ESR2_21235772_ChIP-Seq_MCF-7_Human1.92526264
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92016296
10STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91529836
11ZNF263_19887448_ChIP-Seq_K562_Human1.85038430
12KDM2B_26808549_Chip-Seq_K562_Human1.78266237
13EP300_21415370_ChIP-Seq_HL-1_Mouse1.77061996
14TP63_17297297_ChIP-ChIP_HaCaT_Human1.76213205
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75733499
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73496832
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.72594086
18CLOCK_20551151_ChIP-Seq_293T_Human1.72159535
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66407546
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66227514
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61223443
22LXR_22292898_ChIP-Seq_THP-1_Human1.59069806
23KDM2B_26808549_Chip-Seq_DND41_Human1.58099290
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.55218321
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.55218321
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55160240
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52718133
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.50550594
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49892302
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49305287
31NCOR1_26117541_ChIP-Seq_K562_Human1.49143754
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48137099
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.47516097
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47127319
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46369988
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45960743
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45663191
38ATF3_27146783_Chip-Seq_COLON_Human1.45519260
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45482276
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44090141
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43816524
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43628278
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40781736
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40781736
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.40327019
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36801263
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36573085
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34356242
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.32882963
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.31870163
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31255042
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31255042
53TP53_22127205_ChIP-Seq_IMR90_Human1.30875807
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29996677
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28067762
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.27461644
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27122445
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26483059
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26019212
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25628112
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25406236
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.24444768
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24403130
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.24088263
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23769451
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.23700537
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23228316
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.23208628
69RACK7_27058665_Chip-Seq_MCF-7_Human1.21709309
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20112914
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.19840787
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19681739
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.19651187
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19501357
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.19082859
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.18674067
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18493826
78GATA1_19941826_ChIP-Seq_K562_Human1.18377344
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17129715
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.16823748
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15781496
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15672866
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15287597
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15145563
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15048227
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14914685
87CREB1_26743006_Chip-Seq_LNCaP_Human1.14582983
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13172268
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12665833
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12145237
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12066773
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.12002811
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10904891
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09330629
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08311746
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08124759
97KLF5_25053715_ChIP-Seq_YYC3_Human1.07772466
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07216776
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06703536
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06412644
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06154026
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05827451
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05780247
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05235183
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04981084
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04779842
107AHR_22903824_ChIP-Seq_MCF-7_Human1.04773863
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.04712883
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04187643
110CTCF_27219007_Chip-Seq_Bcells_Human1.03962666
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.03667874
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03254540
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01559431
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01306295
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00966012
116TCF7_22412390_ChIP-Seq_EML_Mouse1.00077424
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.99261570
118TP63_22573176_ChIP-Seq_HFKS_Human0.98618850
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98609437
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98402341
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96464809
122* SMC4_20622854_ChIP-Seq_HELA_Human0.95062721
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94965194
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94870708
125JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93907655
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93859947
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.92625537
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.91922331
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90949549
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89200615
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.88872879
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88428006
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88219556
134GATA2_19941826_ChIP-Seq_K562_Human0.87901059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.28869175
2MP0000751_myopathy3.48852568
3MP0003705_abnormal_hypodermis_morpholog3.21336166
4MP0008438_abnormal_cutaneous_collagen3.07530437
5MP0004084_abnormal_cardiac_muscle3.02089563
6MP0004859_abnormal_synaptic_plasticity2.55141741
7MP0005275_abnormal_skin_tensile2.54833883
8MP0009780_abnormal_chondrocyte_physiolo2.48472753
9MP0004130_abnormal_muscle_cell2.47050887
10MP0002909_abnormal_adrenal_gland2.42394078
11MP0004036_abnormal_muscle_relaxation2.40557128
12MP0005257_abnormal_intraocular_pressure2.23668614
13MP0005409_darkened_coat_color2.14317720
14MP0005451_abnormal_body_composition2.06697030
15MP0000013_abnormal_adipose_tissue2.05982277
16MP0005623_abnormal_meninges_morphology2.03501968
17MP0004087_abnormal_muscle_fiber2.03052213
18MP0002877_abnormal_melanocyte_morpholog2.02690733
19MP0004145_abnormal_muscle_electrophysio1.93858111
20MP0003646_muscle_fatigue1.90426236
21MP0000747_muscle_weakness1.86814128
22MP0000749_muscle_degeneration1.86462056
23MP0004185_abnormal_adipocyte_glucose1.86224306
24MP0003283_abnormal_digestive_organ1.84323404
25MP0004215_abnormal_myocardial_fiber1.83079644
26MP0008961_abnormal_basal_metabolism1.76953157
27MP0005330_cardiomyopathy1.75281818
28MP0003950_abnormal_plasma_membrane1.73277948
29MP0005666_abnormal_adipose_tissue1.71357301
30MP0010234_abnormal_vibrissa_follicle1.70659062
31MP0000678_abnormal_parathyroid_gland1.68635302
32MP0002269_muscular_atrophy1.67490554
33MP0003300_gastrointestinal_ulcer1.67404204
34MP0003566_abnormal_cell_adhesion1.66475533
35MP0003045_fibrosis1.66436225
36MP0001348_abnormal_lacrimal_gland1.65540117
37MP0003329_amyloid_beta_deposits1.65060892
38MP0004858_abnormal_nervous_system1.60080168
39MP0005375_adipose_tissue_phenotype1.59739089
40MP0000003_abnormal_adipose_tissue1.59543712
41MP0008775_abnormal_heart_ventricle1.53240837
42MP0004272_abnormal_basement_membrane1.52409737
43MP0005023_abnormal_wound_healing1.52393854
44MP0000750_abnormal_muscle_regeneration1.51350531
45MP0000759_abnormal_skeletal_muscle1.45083470
46MP0005620_abnormal_muscle_contractility1.44794354
47MP0005670_abnormal_white_adipose1.44728449
48MP0002972_abnormal_cardiac_muscle1.43439931
49MP0002106_abnormal_muscle_physiology1.39311683
50MP0004233_abnormal_muscle_weight1.39174648
51MP0010630_abnormal_cardiac_muscle1.37414731
52MP0003942_abnormal_urinary_system1.37285055
53MP0006138_congestive_heart_failure1.31745356
54MP0003453_abnormal_keratinocyte_physiol1.30843473
55MP0000767_abnormal_smooth_muscle1.29466946
56MP0010030_abnormal_orbit_morphology1.27811470
57MP0002234_abnormal_pharynx_morphology1.25920881
58MP0001243_abnormal_dermal_layer1.24070147
59MP0004270_analgesia1.23663376
60MP0005385_cardiovascular_system_phenoty1.21540606
61MP0001544_abnormal_cardiovascular_syste1.21540606
62MP0005369_muscle_phenotype1.20430794
63MP0003279_aneurysm1.19439820
64MP0004085_abnormal_heartbeat1.18389031
65MP0005083_abnormal_biliary_tract1.17356317
66MP0004510_myositis1.16569001
67MP0000566_synostosis1.16396514
68MP0010352_gastrointestinal_tract_polyps1.14057045
69MP0003137_abnormal_impulse_conducting1.13824205
70MP0003385_abnormal_body_wall1.12465214
71MP0002249_abnormal_larynx_morphology1.11843095
72MP0005508_abnormal_skeleton_morphology1.10893710
73MP0003635_abnormal_synaptic_transmissio1.09097570
74MP0001958_emphysema1.06804343
75MP0004264_abnormal_extraembryonic_tissu1.05713871
76MP0004484_altered_response_of1.03670781
77MP0004134_abnormal_chest_morphology1.02771607
78MP0001299_abnormal_eye_distance/1.02179895
79MP0002896_abnormal_bone_mineralization1.01960035
80MP0000467_abnormal_esophagus_morphology1.01711870
81MP0005501_abnormal_skin_physiology0.97869633
82MP0000462_abnormal_digestive_system0.97851684
83MP0000733_abnormal_muscle_development0.97022938
84MP0000762_abnormal_tongue_morphology0.96642178
85MP0003091_abnormal_cell_migration0.96347441
86MP0000534_abnormal_ureter_morphology0.95561263
87MP0002108_abnormal_muscle_morphology0.94841746
88MP0009840_abnormal_foam_cell0.93848265
89MP0002078_abnormal_glucose_homeostasis0.91985554
90MP0005076_abnormal_cell_differentiation0.91930612
91MP0003941_abnormal_skin_development0.91291504
92MP0001849_ear_inflammation0.90435862
93MP0003252_abnormal_bile_duct0.90391141
94MP0000604_amyloidosis0.90026728
95MP0008569_lethality_at_weaning0.88743688
96MP0005187_abnormal_penis_morphology0.88218623
97MP0000377_abnormal_hair_follicle0.86827452
98MP0005503_abnormal_tendon_morphology0.86251590
99MP0000569_abnormal_digit_pigmentation0.85443620
100MP0005167_abnormal_blood-brain_barrier0.84037044
101MP0000428_abnormal_craniofacial_morphol0.83704588
102MP0002971_abnormal_brown_adipose0.83133607
103MP0005058_abnormal_lysosome_morphology0.82998278
104MP0001879_abnormal_lymphatic_vessel0.82525556
105MP0010771_integument_phenotype0.81916199
106MP0010329_abnormal_lipoprotein_level0.81874421
107MP0002118_abnormal_lipid_homeostasis0.81121276
108MP0002796_impaired_skin_barrier0.80445333
109MP0001216_abnormal_epidermal_layer0.79981577
110MP0002060_abnormal_skin_morphology0.79466152
111MP0003959_abnormal_lean_body0.78154632
112MP0004043_abnormal_pH_regulation0.76525446
113MP0009931_abnormal_skin_appearance0.74684265
114MP0005535_abnormal_body_temperature0.74383672
115MP0005408_hypopigmentation0.73544040
116MP0001661_extended_life_span0.73208769
117MP0002925_abnormal_cardiovascular_devel0.72552744
118MP0010678_abnormal_skin_adnexa0.72063985
119MP0003172_abnormal_lysosome_physiology0.70461748
120MP0001765_abnormal_ion_homeostasis0.70084157
121MP0001614_abnormal_blood_vessel0.69701385
122MP0001440_abnormal_grooming_behavior0.68820148
123MP0002089_abnormal_postnatal_growth/wei0.68375489
124MP0009384_cardiac_valve_regurgitation0.68216155
125MP0002128_abnormal_blood_circulation0.67687198
126MP0003115_abnormal_respiratory_system0.67603612
127MP0005448_abnormal_energy_balance0.66933790
128MP0001944_abnormal_pancreas_morphology0.66243675
129MP0000266_abnormal_heart_morphology0.66233008
130MP0003879_abnormal_hair_cell0.65707943
131MP0009046_muscle_twitch0.64584099
132MP0002295_abnormal_pulmonary_circulatio0.64522039
133MP0002063_abnormal_learning/memory/cond0.64421752
134MP0002098_abnormal_vibrissa_morphology0.64315630
135MP0005595_abnormal_vascular_smooth0.63832564
136MP0002168_other_aberrant_phenotype0.63507227
137MP0002090_abnormal_vision0.62746395
138MP0005365_abnormal_bile_salt0.62691934
139MP0003633_abnormal_nervous_system0.62680885
140MP0002116_abnormal_craniofacial_bone0.62523123
141MP0004811_abnormal_neuron_physiology0.62341404
142MP0003191_abnormal_cellular_cholesterol0.62271756
143MP0000432_abnormal_head_morphology0.61186516
144MP0010368_abnormal_lymphatic_system0.61142478
145MP0000579_abnormal_nail_morphology0.61031366
146MP0000383_abnormal_hair_follicle0.60303349
147MP0003935_abnormal_craniofacial_develop0.60006994

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)3.81372163
2Hyporeflexia of lower limbs (HP:0002600)3.75537769
3Right ventricular cardiomyopathy (HP:0011663)3.47182447
4Difficulty running (HP:0009046)3.42110607
5Cerebral aneurysm (HP:0004944)3.42075160
6Increased connective tissue (HP:0009025)3.29825324
7Exercise-induced myalgia (HP:0003738)3.26506867
8Muscle fiber splitting (HP:0003555)3.20573245
9Bundle branch block (HP:0011710)3.16801752
10Type 1 muscle fiber predominance (HP:0003803)3.11097838
11Increased variability in muscle fiber diameter (HP:0003557)3.02789622
12Asymmetric septal hypertrophy (HP:0001670)2.97783271
13Vascular tortuosity (HP:0004948)2.96264532
14Difficulty climbing stairs (HP:0003551)2.95009755
15Arterial tortuosity (HP:0005116)2.90399352
16Protrusio acetabuli (HP:0003179)2.89118951
17Exercise-induced muscle cramps (HP:0003710)2.88663531
18Abnormality of dentin (HP:0010299)2.84291227
19Ventricular tachycardia (HP:0004756)2.80326292
20Premature rupture of membranes (HP:0001788)2.79277354
21Soft skin (HP:0000977)2.78910265
22Ventricular fibrillation (HP:0001663)2.75455759
23Mildly elevated creatine phosphokinase (HP:0008180)2.75267403
24Distal upper limb amyotrophy (HP:0007149)2.73442144
25Upper limb amyotrophy (HP:0009129)2.73442144
26Broad metatarsal (HP:0001783)2.70784740
27Abnormality of skeletal muscle fiber size (HP:0012084)2.58046753
28Wormian bones (HP:0002645)2.55332525
29Myoglobinuria (HP:0002913)2.54681285
30Ankyloglossia (HP:0010296)2.50750017
31Biconcave vertebral bodies (HP:0004586)2.42746444
32Aneurysm (HP:0002617)2.41959156
33Blue sclerae (HP:0000592)2.41759545
34Syncope (HP:0001279)2.40378016
35Disproportionate tall stature (HP:0001519)2.37919746
36Abnormality of the calf musculature (HP:0001430)2.37773650
37Ulnar bowing (HP:0003031)2.37065126
38Shallow orbits (HP:0000586)2.37039434
39Follicular hyperkeratosis (HP:0007502)2.36163050
40Neonatal short-limb short stature (HP:0008921)2.35225596
41Atelectasis (HP:0100750)2.34961344
42Calf muscle hypertrophy (HP:0008981)2.34378616
43Hand muscle atrophy (HP:0009130)2.33404614
44Ventricular arrhythmia (HP:0004308)2.32900271
45Atrial fibrillation (HP:0005110)2.32096346
46Abnormality of the lower motor neuron (HP:0002366)2.31757389
47Flat cornea (HP:0007720)2.30136303
48Round ear (HP:0100830)2.27585085
49Prolonged QT interval (HP:0001657)2.27176829
50Obstructive sleep apnea (HP:0002870)2.26549447
51Bladder diverticulum (HP:0000015)2.25216516
52Atrophic scars (HP:0001075)2.24997882
53Ankle contracture (HP:0006466)2.24501146
54Myotonia (HP:0002486)2.24212186
55Broad face (HP:0000283)2.24061685
56EMG: myopathic abnormalities (HP:0003458)2.23986976
57Atrioventricular block (HP:0001678)2.23728587
58Hyperextensible skin (HP:0000974)2.23248538
59Lymphangioma (HP:0100764)2.22567624
60Dysmetric saccades (HP:0000641)2.22281706
61Primary atrial arrhythmia (HP:0001692)2.22250284
62Venous abnormality (HP:0002624)2.21855195
63Hyperacusis (HP:0010780)2.20934115
64Genu recurvatum (HP:0002816)2.20515902
65Joint laxity (HP:0001388)2.19336640
66Overgrowth (HP:0001548)2.16181678
67Muscle hypertrophy of the lower extremities (HP:0008968)2.15020795
68J-shaped sella turcica (HP:0002680)2.14978118
69Rapidly progressive (HP:0003678)2.14954645
70Long toe (HP:0010511)2.14510945
71Flat acetabular roof (HP:0003180)2.12572459
72Scapular winging (HP:0003691)2.12376263
73Heart block (HP:0012722)2.12043502
74Ketoacidosis (HP:0001993)2.11588444
75Abnormality of the acetabulum (HP:0003170)2.11567319
76Abnormal atrioventricular conduction (HP:0005150)2.11438983
77Asymmetry of the thorax (HP:0001555)2.11220959
78Venous insufficiency (HP:0005293)2.10316189
79Achilles tendon contracture (HP:0001771)2.09561439
80Abnormality of oral frenula (HP:0000190)2.09313782
81Vertebral compression fractures (HP:0002953)2.08704449
82Breech presentation (HP:0001623)2.08090921
83Mitral valve prolapse (HP:0001634)2.06973589
84Supraventricular arrhythmia (HP:0005115)2.06711897
85Hyperthyroidism (HP:0000836)2.06508735
86Peritonitis (HP:0002586)2.05709752
87Mitral regurgitation (HP:0001653)2.05172062
88Aortic aneurysm (HP:0004942)2.04764848
89Subaortic stenosis (HP:0001682)2.03325645
90Abnormality of the left ventricular outflow tract (HP:0011103)2.03325645
91Truncus arteriosus (HP:0001660)2.03078959
92Advanced eruption of teeth (HP:0006288)2.03022171
93Supraventricular tachycardia (HP:0004755)2.02303873
94Abnormal delivery (HP:0001787)2.02009053
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00307716
96Hamartoma of the eye (HP:0010568)1.99411712
97Abnormality of the Achilles tendon (HP:0005109)1.98348065
98Short nail (HP:0001799)1.98178768
99Fragile skin (HP:0001030)1.98143699
100Ulnar deviation of the wrist (HP:0003049)1.97722773
101Distal lower limb amyotrophy (HP:0008944)1.97396432
102Cerebral inclusion bodies (HP:0100314)1.97257562
103Lower limb amyotrophy (HP:0007210)1.97255731
104Supranuclear gaze palsy (HP:0000605)1.95450920
105Insomnia (HP:0100785)1.94608490
106Aortic dissection (HP:0002647)1.94101178
107Global brain atrophy (HP:0002283)1.94096959
108Mitral stenosis (HP:0001718)1.93956384
109Renal duplication (HP:0000075)1.93909057
110Aortic regurgitation (HP:0001659)1.93886966
111Lipoatrophy (HP:0100578)1.93580647
112Slender build (HP:0001533)1.92640800
113EMG: neuropathic changes (HP:0003445)1.92441688
114Elbow flexion contracture (HP:0002987)1.92386641
115Hypercortisolism (HP:0001578)1.92219144
116Visual hallucinations (HP:0002367)1.91196980
117Bell-shaped thorax (HP:0001591)1.88411069
118Spinal rigidity (HP:0003306)1.87119891
119Frequent falls (HP:0002359)1.85750543
120Dilatation of the ascending aorta (HP:0005111)1.84874745
121Patellar dislocation (HP:0002999)1.83696731
122Natal tooth (HP:0000695)1.82740380
123Nonimmune hydrops fetalis (HP:0001790)1.82444487
124Osteoarthritis (HP:0002758)1.81864860
125Hypoplastic ischia (HP:0003175)1.81823295
126Abnormality of the tricuspid valve (HP:0001702)1.81131116
127Persistence of primary teeth (HP:0006335)1.80699819
128Macroorchidism (HP:0000053)1.78200032
129Distal lower limb muscle weakness (HP:0009053)1.78114793
130Termporal pattern (HP:0011008)1.78016969
131Insidious onset (HP:0003587)1.78016969
132Limb-girdle muscle atrophy (HP:0003797)1.77864369
133Bowel diverticulosis (HP:0005222)1.77773138
134Skin nodule (HP:0200036)1.76354671
135Striae distensae (HP:0001065)1.74173952
136Stridor (HP:0010307)1.72940434
137Action tremor (HP:0002345)1.72687721
138Enlarged penis (HP:0000040)1.72395943
139Insulin-resistant diabetes mellitus (HP:0000831)1.72229264
140Polycythemia (HP:0001901)1.71793890
141Deformed sella turcica (HP:0002681)1.71487729
142Wide anterior fontanel (HP:0000260)1.71185752
143Abnormality of the ischium (HP:0003174)1.70855474
144Cervical subluxation (HP:0003308)1.70452008
145Turricephaly (HP:0000262)1.69438481
146Osteolytic defects of the hand bones (HP:0009699)1.69345870
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.69345870
148Resting tremor (HP:0002322)1.69253154
149Buphthalmos (HP:0000557)1.69245177
150Abnormality of nail color (HP:0100643)1.68778817
151Sparse lateral eyebrow (HP:0005338)1.68728512
152Reticulocytosis (HP:0001923)1.68519891
153Congenital glaucoma (HP:0001087)1.67048789
154Hyperinsulinemic hypoglycemia (HP:0000825)1.66347188
155Hyperglycemia (HP:0003074)1.65536154
156Ectopia lentis (HP:0001083)1.65378326
157Abnormal EKG (HP:0003115)1.65339593
158Thin bony cortex (HP:0002753)1.63400487
159Vertebral arch anomaly (HP:0008438)1.63040121
160Sudden cardiac death (HP:0001645)1.62109361
161Premature skin wrinkling (HP:0100678)1.60690614
162Neoplasm of the heart (HP:0100544)1.59983392
163Bronchomalacia (HP:0002780)1.59672746
164Renovascular hypertension (HP:0100817)1.57995701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.36316554
2TTN3.20094529
3PKN22.78394336
4LMTK22.69941445
5ERN12.34079491
6RIPK12.27464047
7EPHA22.10127421
8PDGFRA1.99279397
9SIK11.96693837
10PRKD31.93797898
11MAP3K91.93115038
12CDK121.83201099
13DMPK1.82288578
14MST1R1.72820312
15EEF2K1.69411763
16PTK61.68172746
17PHKG21.64862725
18PHKG11.64862725
19PDK31.64531701
20PDK41.64531701
21MAP3K61.52100753
22NTRK11.49786023
23CAMK1G1.47825911
24FER1.41936180
25MET1.40358677
26DDR21.38813080
27RET1.37571081
28KSR21.35304592
29PAK61.34207045
30NTRK31.30345251
31MAP3K21.30239605
32CAMKK11.28386744
33AKT31.23061595
34LATS21.22484226
35PAK31.22110729
36CAMK1D1.20044505
37PRKCH1.18542694
38EPHB11.16364269
39LATS11.16307291
40STK381.16143217
41ICK1.15527749
42IRAK31.13120846
43SMG11.12770659
44MAP3K71.12215911
45PTK2B1.09507894
46PTK21.08677673
47TAOK11.04393299
48PDGFRB1.01788020
49PRPF4B1.00934433
50MAP3K101.00162392
51TYRO30.97887599
52PRKD10.96954888
53SCYL20.90176729
54WNK10.89546394
55CDC42BPA0.88602844
56MAP3K40.88301213
57WNK40.88025340
58DAPK20.87019897
59PAK40.85270707
60MTOR0.83219053
61FGFR40.83117349
62MARK20.83084087
63PIK3CG0.82709198
64PDPK10.79698815
65TESK10.79275791
66RPS6KB20.79069482
67SIK20.78909468
68BMX0.78909325
69PDK20.77502324
70MAP2K40.77340794
71MAP3K10.76361775
72FRK0.76013417
73TAOK30.75771844
74ROCK10.74597031
75NEK90.74023831
76FGFR20.73919634
77CLK10.72146958
78JAK10.71556052
79PRKAA10.69153582
80INSRR0.68638972
81NEK10.67940706
82SGK30.66505136
83PAK20.66394682
84LRRK20.66092771
85EPHA30.65941479
86OBSCN0.65567510
87RPS6KA20.64366724
88CDK50.64073457
89ALK0.62203287
90MYLK0.61980233
91EPHB20.61855588
92PDK10.61389192
93MAP2K10.60717486
94MINK10.60434471
95MAPKAPK30.59994829
96EPHA40.58911997
97KSR10.56934495
98PIK3CA0.56908052
99BCKDK0.55751679
100STK110.55498267
101MAPK120.55199456
102STK30.54871836
103ILK0.53615053
104NTRK20.52935797
105MAP2K30.52690453
106HIPK20.51502003
107MAPK150.50687522
108MAP2K20.50406999
109MAPK110.49770548
110RAF10.49709895
111JAK20.49706242
112MAP3K30.49382163
113WNK30.48570752
114MAP3K130.47885918
115NME10.47747699
116RIPK40.47320172
117CAMKK20.45307360
118ROCK20.44478164
119PRKAA20.43848299
120TRPM70.43689823
121MAP2K60.43396696
122FGFR30.43349147
123UHMK10.43258495
124AKT20.42783846
125PRKD20.42690195
126PRKG20.42400873
127RPS6KL10.41803588
128RPS6KC10.41803588
129NEK20.40003943
130CAMK2D0.39589801
131MARK10.39410278
132MUSK0.38615155
133MAPK100.38078335
134GRK50.36497006

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92617716
2Dilated cardiomyopathy_Homo sapiens_hsa054141.81725516
3Other glycan degradation_Homo sapiens_hsa005111.80222965
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77511080
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56901310
6Type II diabetes mellitus_Homo sapiens_hsa049301.56796359
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56041191
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45912285
9Insulin secretion_Homo sapiens_hsa049111.45078877
10Nitrogen metabolism_Homo sapiens_hsa009101.42683491
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40610063
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38391194
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34379301
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32019708
15Gastric acid secretion_Homo sapiens_hsa049711.31497210
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30030822
17Acute myeloid leukemia_Homo sapiens_hsa052211.29563433
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27899475
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.27474188
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27125404
21Non-small cell lung cancer_Homo sapiens_hsa052231.27074434
22Thyroid cancer_Homo sapiens_hsa052161.25244524
23Insulin resistance_Homo sapiens_hsa049311.25081175
24Fatty acid degradation_Homo sapiens_hsa000711.22681137
25Glucagon signaling pathway_Homo sapiens_hsa049221.18252854
26Estrogen signaling pathway_Homo sapiens_hsa049151.14234545
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14215400
28Focal adhesion_Homo sapiens_hsa045101.14092326
29Notch signaling pathway_Homo sapiens_hsa043301.13888680
30Small cell lung cancer_Homo sapiens_hsa052221.13539627
31Fatty acid metabolism_Homo sapiens_hsa012121.13074591
32Pancreatic cancer_Homo sapiens_hsa052121.11859869
33Inositol phosphate metabolism_Homo sapiens_hsa005621.11536786
34Renin secretion_Homo sapiens_hsa049241.11318109
35Long-term potentiation_Homo sapiens_hsa047201.09528273
36ECM-receptor interaction_Homo sapiens_hsa045121.08847893
37Circadian entrainment_Homo sapiens_hsa047131.08093397
38mTOR signaling pathway_Homo sapiens_hsa041501.08026478
39Insulin signaling pathway_Homo sapiens_hsa049101.07927867
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07298835
41PPAR signaling pathway_Homo sapiens_hsa033201.06692008
42Propanoate metabolism_Homo sapiens_hsa006401.06511997
43MicroRNAs in cancer_Homo sapiens_hsa052061.05399123
44Dorso-ventral axis formation_Homo sapiens_hsa043201.04983821
45Bile secretion_Homo sapiens_hsa049761.04128631
46Prolactin signaling pathway_Homo sapiens_hsa049171.03965215
47Prion diseases_Homo sapiens_hsa050201.03426486
48Salivary secretion_Homo sapiens_hsa049701.03387741
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03304653
50Oxytocin signaling pathway_Homo sapiens_hsa049211.03112053
51Fructose and mannose metabolism_Homo sapiens_hsa000511.02410770
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.02240419
53Protein digestion and absorption_Homo sapiens_hsa049740.99344931
54GnRH signaling pathway_Homo sapiens_hsa049120.98881311
55Synaptic vesicle cycle_Homo sapiens_hsa047210.98591915
56AMPK signaling pathway_Homo sapiens_hsa041520.96631866
57Glioma_Homo sapiens_hsa052140.95369031
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93875119
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93529342
60Pancreatic secretion_Homo sapiens_hsa049720.92673478
61Cholinergic synapse_Homo sapiens_hsa047250.92289429
62Olfactory transduction_Homo sapiens_hsa047400.91841435
63Prostate cancer_Homo sapiens_hsa052150.90020351
64Amphetamine addiction_Homo sapiens_hsa050310.89606331
65Amoebiasis_Homo sapiens_hsa051460.87463686
66Thyroid hormone synthesis_Homo sapiens_hsa049180.86955186
67Cardiac muscle contraction_Homo sapiens_hsa042600.86882806
68Lysine degradation_Homo sapiens_hsa003100.86143276
69Dopaminergic synapse_Homo sapiens_hsa047280.86037392
70HIF-1 signaling pathway_Homo sapiens_hsa040660.85297087
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.84554937
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84386736
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84276980
74Fatty acid biosynthesis_Homo sapiens_hsa000610.84239751
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83312568
76Butanoate metabolism_Homo sapiens_hsa006500.81959437
77Cocaine addiction_Homo sapiens_hsa050300.81332080
78Arginine biosynthesis_Homo sapiens_hsa002200.81058821
79Fat digestion and absorption_Homo sapiens_hsa049750.80789651
80VEGF signaling pathway_Homo sapiens_hsa043700.79586218
81Gap junction_Homo sapiens_hsa045400.79530053
82GABAergic synapse_Homo sapiens_hsa047270.79431813
83Proteoglycans in cancer_Homo sapiens_hsa052050.79288985
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78600807
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.76816681
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76557362
87Axon guidance_Homo sapiens_hsa043600.75466319
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75034536
89cAMP signaling pathway_Homo sapiens_hsa040240.74358695
90Renal cell carcinoma_Homo sapiens_hsa052110.73396532
91Glutamatergic synapse_Homo sapiens_hsa047240.72022401
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.71091173
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70891391
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.70202123
95Glycerolipid metabolism_Homo sapiens_hsa005610.69504833
96Pyruvate metabolism_Homo sapiens_hsa006200.69026300
97Calcium signaling pathway_Homo sapiens_hsa040200.68937525
98Pathways in cancer_Homo sapiens_hsa052000.68393417
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.67982108
100Carbon metabolism_Homo sapiens_hsa012000.67503173
101Melanoma_Homo sapiens_hsa052180.67483263
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67054832
103Vibrio cholerae infection_Homo sapiens_hsa051100.66114500
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64693838
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64279102
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.64098976
107Chronic myeloid leukemia_Homo sapiens_hsa052200.64024096
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.64013564
109ABC transporters_Homo sapiens_hsa020100.63840829
110Morphine addiction_Homo sapiens_hsa050320.63557431
111Starch and sucrose metabolism_Homo sapiens_hsa005000.63438327
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62889560
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62858661
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62809566
115Endometrial cancer_Homo sapiens_hsa052130.62433469
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61778495
117Melanogenesis_Homo sapiens_hsa049160.61547556
118Platelet activation_Homo sapiens_hsa046110.60318045
119Rap1 signaling pathway_Homo sapiens_hsa040150.59632835
120Galactose metabolism_Homo sapiens_hsa000520.59051435
121Adherens junction_Homo sapiens_hsa045200.57663380
122Endocytosis_Homo sapiens_hsa041440.57531358
123N-Glycan biosynthesis_Homo sapiens_hsa005100.56849660
124Tight junction_Homo sapiens_hsa045300.56342795
125Hippo signaling pathway_Homo sapiens_hsa043900.56003634
126ErbB signaling pathway_Homo sapiens_hsa040120.55806693
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55356248
128Ovarian steroidogenesis_Homo sapiens_hsa049130.54816107
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.54134577
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54081928
131Sphingolipid metabolism_Homo sapiens_hsa006000.53997777
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53603838
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53211463
134Taste transduction_Homo sapiens_hsa047420.52084185
135Long-term depression_Homo sapiens_hsa047300.52019503
136Complement and coagulation cascades_Homo sapiens_hsa046100.51762619
137Choline metabolism in cancer_Homo sapiens_hsa052310.50911249
138Bladder cancer_Homo sapiens_hsa052190.50873873

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