ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.23120537
2	protein K11-linked deubiquitination (GO:0035871)	5.12304262
3	sperm motility (GO:0030317)	5.01156510
4	cilium or flagellum-dependent cell motility (GO:0001539)	4.78280427
5	piRNA metabolic process (GO:0034587)	4.76546186
6	acrosome reaction (GO:0007340)	4.67897646
7	indole-containing compound catabolic process (GO:0042436)	4.55564485
8	indolalkylamine catabolic process (GO:0046218)	4.55564485
9	tryptophan catabolic process (GO:0006569)	4.55564485
10	multicellular organism reproduction (GO:0032504)	4.54785580
11	tachykinin receptor signaling pathway (GO:0007217)	4.33570486
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.18575627
13	establishment of protein localization to Golgi (GO:0072600)	4.17489927
14	male meiosis (GO:0007140)	4.10428085
15	indolalkylamine metabolic process (GO:0006586)	4.07323438
16	DNA methylation involved in gamete generation (GO:0043046)	3.99453403
17	DNA double-strand break processing (GO:0000729)	3.95670402
18	signal peptide processing (GO:0006465)	3.91166354
19	L-fucose catabolic process (GO:0042355)	3.88899082
20	fucose catabolic process (GO:0019317)	3.88899082
21	L-fucose metabolic process (GO:0042354)	3.88899082
22	synapsis (GO:0007129)	3.87813141
23	tryptophan metabolic process (GO:0006568)	3.78801939
24	kynurenine metabolic process (GO:0070189)	3.76667554
25	sperm-egg recognition (GO:0035036)	3.71193645
26	epithelial cilium movement (GO:0003351)	3.65359826
27	fusion of sperm to egg plasma membrane (GO:0007342)	3.64048219
28	spermatid development (GO:0007286)	3.55648049
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.54462627
30	detection of light stimulus involved in visual perception (GO:0050908)	3.54462627
31	protein targeting to Golgi (GO:0000042)	3.52023798
32	regulation of meiosis I (GO:0060631)	3.51020138
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50308256
34	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.50170462
35	protein polyglutamylation (GO:0018095)	3.50006282
36	male meiosis I (GO:0007141)	3.47471974
37	cellular ketone body metabolic process (GO:0046950)	3.46873486
38	photoreceptor cell maintenance (GO:0045494)	3.46609597
39	behavioral response to nicotine (GO:0035095)	3.28364282
40	centriole replication (GO:0007099)	3.24861215
41	amine catabolic process (GO:0009310)	3.23302043
42	cellular biogenic amine catabolic process (GO:0042402)	3.23302043
43	regulation of hippo signaling (GO:0035330)	3.22410951
44	cell-cell recognition (GO:0009988)	3.21938101
45	axoneme assembly (GO:0035082)	3.21301181
46	protein K48-linked deubiquitination (GO:0071108)	3.20238098
47	reproduction (GO:0000003)	3.20097589
48	reflex (GO:0060004)	3.18945599
49	NAD biosynthetic process (GO:0009435)	3.18723981
50	behavioral response to ethanol (GO:0048149)	3.17661238
51	cilium movement (GO:0003341)	3.16694560
52	reciprocal DNA recombination (GO:0035825)	3.15471915
53	reciprocal meiotic recombination (GO:0007131)	3.15471915
54	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.14871617
55	retinal cone cell development (GO:0046549)	3.12283303
56	ketone body metabolic process (GO:1902224)	3.09189578
57	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.07556955
58	phosphatidylethanolamine metabolic process (GO:0046337)	3.02941334
59	neural tube formation (GO:0001841)	3.01652305
60	microtubule polymerization or depolymerization (GO:0031109)	3.00748189
61	adaptation of signaling pathway (GO:0023058)	2.99071806
62	sulfation (GO:0051923)	2.94401340
63	auditory receptor cell stereocilium organization (GO:0060088)	2.90577743
64	negative regulation of mast cell activation (GO:0033004)	2.90169302
65	chromosome organization involved in meiosis (GO:0070192)	2.89995508
66	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.88294816
67	double-strand break repair via homologous recombination (GO:0000724)	2.85258377
68	DNA integration (GO:0015074)	2.85128031
69	indole-containing compound metabolic process (GO:0042430)	2.82598924
70	recombinational repair (GO:0000725)	2.82571923
71	cilium organization (GO:0044782)	2.78660521
72	cilium assembly (GO:0042384)	2.77814280
73	plasma membrane fusion (GO:0045026)	2.76797185
74	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.76734261
75	regulation of cilium movement (GO:0003352)	2.76303286
76	single strand break repair (GO:0000012)	2.75585592
77	axonemal dynein complex assembly (GO:0070286)	2.72515240
78	male gamete generation (GO:0048232)	2.71704496
79	spermatogenesis (GO:0007283)	2.71658213
80	prenylation (GO:0097354)	2.70621010
81	protein prenylation (GO:0018342)	2.70621010
82	microtubule depolymerization (GO:0007019)	2.70499369
83	cilium morphogenesis (GO:0060271)	2.70182384
84	benzene-containing compound metabolic process (GO:0042537)	2.68891245
85	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65320597
86	single fertilization (GO:0007338)	2.62253968
87	monoubiquitinated protein deubiquitination (GO:0035520)	2.62031822
88	dopamine transport (GO:0015872)	2.61643273
89	binding of sperm to zona pellucida (GO:0007339)	2.61641404
90	meiotic nuclear division (GO:0007126)	2.61026380
91	regulation of acrosome reaction (GO:0060046)	2.60274588
92	rRNA methylation (GO:0031167)	2.59634495
93	meiosis I (GO:0007127)	2.59270553
94	protein K63-linked deubiquitination (GO:0070536)	2.58423098
95	gene silencing by RNA (GO:0031047)	2.57790507
96	fertilization (GO:0009566)	2.53200167
97	gamete generation (GO:0007276)	2.52313269
98	centriole assembly (GO:0098534)	2.52048289
99	positive regulation of developmental pigmentation (GO:0048087)	2.49889345
100	cellular response to sterol (GO:0036315)	2.49803031

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.37117250
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17543663
3	VDR_22108803_ChIP-Seq_LS180_Human	2.91794429
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83188346
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80409708
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75851346
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.59680835
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47584109
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41979792
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38396857
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36935421
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16952080
13	P300_19829295_ChIP-Seq_ESCs_Human	2.16413661
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.14520469
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.12865369
16	FUS_26573619_Chip-Seq_HEK293_Human	2.11704617
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00556978
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.98534246
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97813637
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.93194698
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.91739617
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.91739617
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.91661669
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89764634
25	STAT3_23295773_ChIP-Seq_U87_Human	1.89622023
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81214122
27	EWS_26573619_Chip-Seq_HEK293_Human	1.79290240
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77751644
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76882490
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.76882490
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.74025554
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.73402507
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68317600
34	TCF4_23295773_ChIP-Seq_U87_Human	1.66365163
35	AR_25329375_ChIP-Seq_VCAP_Human	1.65327097
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.59175649
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57838211
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56846807
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56814223
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56484481
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48634658
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.45243706
43	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.45188783
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44606576
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44351348
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.43459733
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.43353534
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42633974
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.40154352
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39517890
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39517363
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39441578
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39441578
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39145093
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38066846
56	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.34930168
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34865469
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.34680910
59	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33500521
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32706207
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30612274
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27190715
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27190715
64	CDX2_22108803_ChIP-Seq_LS180_Human	1.23604586
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21951895
66	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.21860134
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20444830
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.20369229
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17199672
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14904490
71	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.14540529
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14009255
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13207224
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11323401
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11273104
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08477557
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08095148
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08036599
79	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07673946
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07660530
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06334318
82	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04239973
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04096971
84	KDM2B_26808549_Chip-Seq_REH_Human	1.01367391
85	TP53_16413492_ChIP-PET_HCT116_Human	1.01179566
86	DROSHA_22980978_ChIP-Seq_HELA_Human	1.01036276
87	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.00557676
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00032800
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99570960
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99416861
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98691684
92	TBL1_22424771_ChIP-Seq_293T_Human	0.98495776
93	SMRT_27268052_Chip-Seq_Bcells_Human	0.98438804
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98110283
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97941194
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97662128
97	RXR_22108803_ChIP-Seq_LS180_Human	0.97183991
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96056941
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95649531
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95254204

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.84846151
2	MP0000569_abnormal_digit_pigmentation	3.60792599
3	MP0003195_calcinosis	3.11528644
4	MP0008877_abnormal_DNA_methylation	2.88315707
5	MP0001968_abnormal_touch/_nociception	2.76932906
6	MP0002736_abnormal_nociception_after	2.67047955
7	MP0005551_abnormal_eye_electrophysiolog	2.49501577
8	MP0000372_irregular_coat_pigmentation	2.46526472
9	MP0003646_muscle_fatigue	2.42392131
10	MP0008057_abnormal_DNA_replication	2.40805703
11	MP0005075_abnormal_melanosome_morpholog	2.22733177
12	MP0003698_abnormal_male_reproductive	2.17687998
13	MP0001501_abnormal_sleep_pattern	2.11845610
14	MP0001929_abnormal_gametogenesis	1.92081925
15	MP0005377_hearing/vestibular/ear_phenot	1.91941455
16	MP0003878_abnormal_ear_physiology	1.91941455
17	MP0003718_maternal_effect	1.89515518
18	MP0005253_abnormal_eye_physiology	1.81795173
19	MP0002138_abnormal_hepatobiliary_system	1.79732648
20	MP0005174_abnormal_tail_pigmentation	1.79493356
21	MP0001486_abnormal_startle_reflex	1.72029473
22	MP0005310_abnormal_salivary_gland	1.71598322
23	MP0002102_abnormal_ear_morphology	1.70188198
24	MP0005645_abnormal_hypothalamus_physiol	1.69192718
25	MP0000015_abnormal_ear_pigmentation	1.68011013
26	MP0005646_abnormal_pituitary_gland	1.65931018
27	MP0009046_muscle_twitch	1.62423494
28	MP0003011_delayed_dark_adaptation	1.60181912
29	MP0008872_abnormal_physiological_respon	1.60038546
30	MP0001984_abnormal_olfaction	1.59959622
31	MP0005670_abnormal_white_adipose	1.58057407
32	MP0006292_abnormal_olfactory_placode	1.45557706
33	MP0009745_abnormal_behavioral_response	1.44932034
34	MP0002735_abnormal_chemical_nociception	1.42304639
35	MP0001986_abnormal_taste_sensitivity	1.41435172
36	MP0005167_abnormal_blood-brain_barrier	1.40247401
37	MP0002210_abnormal_sex_determination	1.39883847
38	MP0008058_abnormal_DNA_repair	1.38483961
39	MP0006276_abnormal_autonomic_nervous	1.38455329
40	MP0004043_abnormal_pH_regulation	1.37537802
41	MP0004145_abnormal_muscle_electrophysio	1.37149623
42	MP0003045_fibrosis	1.34978481
43	MP0001485_abnormal_pinna_reflex	1.31008152
44	MP0003950_abnormal_plasma_membrane	1.30745067
45	MP0002095_abnormal_skin_pigmentation	1.27774625
46	MP0005395_other_phenotype	1.27444399
47	MP0009697_abnormal_copulation	1.26193672
48	MP0005408_hypopigmentation	1.26148795
49	MP0002876_abnormal_thyroid_physiology	1.24610971
50	MP0002067_abnormal_sensory_capabilities	1.23907349
51	MP0000383_abnormal_hair_follicle	1.23107516
52	MP0004742_abnormal_vestibular_system	1.22946574
53	MP0000427_abnormal_hair_cycle	1.22411355
54	MP0002272_abnormal_nervous_system	1.21846587
55	MP0003136_yellow_coat_color	1.21411286
56	MP0002229_neurodegeneration	1.20200411
57	MP0008875_abnormal_xenobiotic_pharmacok	1.19206507
58	MP0000371_diluted_coat_color	1.17100742
59	MP0002653_abnormal_ependyma_morphology	1.17018028
60	MP0002168_other_aberrant_phenotype	1.15932760
61	MP0000653_abnormal_sex_gland	1.14658882
62	MP0002234_abnormal_pharynx_morphology	1.14517245
63	MP0005647_abnormal_sex_gland	1.13130284
64	MP0001529_abnormal_vocalization	1.10662645
65	MP0001145_abnormal_male_reproductive	1.10559917
66	MP0000631_abnormal_neuroendocrine_gland	1.07743483
67	MP0003183_abnormal_peptide_metabolism	1.07364888
68	MP0002638_abnormal_pupillary_reflex	1.06836305
69	MP0004147_increased_porphyrin_level	1.06598278
70	MP0002928_abnormal_bile_duct	1.02382602
71	MP0006072_abnormal_retinal_apoptosis	0.95600881
72	MP0002161_abnormal_fertility/fecundity	0.95474875
73	MP0004142_abnormal_muscle_tone	0.94415564
74	MP0003252_abnormal_bile_duct	0.93169511
75	MP0001324_abnormal_eye_pigmentation	0.93020816
76	MP0003880_abnormal_central_pattern	0.91616769
77	MP0002572_abnormal_emotion/affect_behav	0.91224996
78	MP0002938_white_spotting	0.91026691
79	MP0001970_abnormal_pain_threshold	0.90733604
80	MP0002733_abnormal_thermal_nociception	0.89180603
81	MP0005671_abnormal_response_to	0.87169110
82	MP0005389_reproductive_system_phenotype	0.86654730
83	MP0001963_abnormal_hearing_physiology	0.84317664
84	MP0005171_absent_coat_pigmentation	0.84281909
85	MP0002557_abnormal_social/conspecific_i	0.83233333
86	MP0008789_abnormal_olfactory_epithelium	0.77762587
87	MP0003635_abnormal_synaptic_transmissio	0.77115747
88	MP0005379_endocrine/exocrine_gland_phen	0.76893871
89	MP0001119_abnormal_female_reproductive	0.76649816
90	MP0001764_abnormal_homeostasis	0.75845049
91	MP0000230_abnormal_systemic_arterial	0.75056067
92	MP0003763_abnormal_thymus_physiology	0.75044369
93	MP0010386_abnormal_urinary_bladder	0.74060870
94	MP0002064_seizures	0.73655394
95	MP0005386_behavior/neurological_phenoty	0.73419833
96	MP0004924_abnormal_behavior	0.73419833
97	MP0009764_decreased_sensitivity_to	0.73257950
98	MP0005195_abnormal_posterior_eye	0.72292331
99	MP0000026_abnormal_inner_ear	0.70807964
100	MP0001348_abnormal_lacrimal_gland	0.70732302

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.34508871
2	Pancreatic cysts (HP:0001737)	4.28970456
3	Pancreatic fibrosis (HP:0100732)	3.66509875
4	True hermaphroditism (HP:0010459)	3.63834231
5	Nephronophthisis (HP:0000090)	3.56687774
6	Severe visual impairment (HP:0001141)	3.47089843
7	Abnormality of midbrain morphology (HP:0002418)	3.39498983
8	Molar tooth sign on MRI (HP:0002419)	3.39498983
9	Congenital stationary night blindness (HP:0007642)	3.28776625
10	Chronic hepatic failure (HP:0100626)	3.25667253
11	Abnormality of the renal medulla (HP:0100957)	3.23283605
12	Abnormality of macular pigmentation (HP:0008002)	3.20466198
13	Bony spicule pigmentary retinopathy (HP:0007737)	3.13462763
14	Decreased central vision (HP:0007663)	3.12315085
15	Abnormality of the renal cortex (HP:0011035)	3.11509580
16	Abolished electroretinogram (ERG) (HP:0000550)	3.08928714
17	Congenital sensorineural hearing impairment (HP:0008527)	3.02420486
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.02068268
19	Bile duct proliferation (HP:0001408)	2.98309639
20	Abnormal biliary tract physiology (HP:0012439)	2.98309639
21	Keratoconus (HP:0000563)	2.79518592
22	Increased corneal curvature (HP:0100692)	2.79518592
23	Gaze-evoked nystagmus (HP:0000640)	2.77526987
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.75742619
25	Absent/shortened dynein arms (HP:0200106)	2.75742619
26	Cystic liver disease (HP:0006706)	2.66850609
27	Hyperventilation (HP:0002883)	2.66176270
28	Tubulointerstitial nephritis (HP:0001970)	2.54609672
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53349662
30	Pendular nystagmus (HP:0012043)	2.53163490
31	Cerebellar dysplasia (HP:0007033)	2.47028216
32	Medial flaring of the eyebrow (HP:0010747)	2.41010638
33	IgG deficiency (HP:0004315)	2.39746641
34	Type II lissencephaly (HP:0007260)	2.37846791
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36677453
36	Febrile seizures (HP:0002373)	2.31978975
37	Absent speech (HP:0001344)	2.31430077
38	Abnormality of B cell number (HP:0010975)	2.30091893
39	Abnormal drinking behavior (HP:0030082)	2.29821555
40	Polydipsia (HP:0001959)	2.29821555
41	Renal cortical cysts (HP:0000803)	2.29653726
42	Congenital hepatic fibrosis (HP:0002612)	2.29314627
43	Abnormal ciliary motility (HP:0012262)	2.24898910
44	Anencephaly (HP:0002323)	2.22362570
45	Inability to walk (HP:0002540)	2.20734911
46	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.20234939
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.15150097
48	Retinal dysplasia (HP:0007973)	2.15058351
49	Progressive cerebellar ataxia (HP:0002073)	2.12957539
50	Sclerocornea (HP:0000647)	2.11651951
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10011146
52	Genetic anticipation (HP:0003743)	2.09492496
53	Tubular atrophy (HP:0000092)	2.09210708
54	Central scotoma (HP:0000603)	2.08894637
55	Thyroiditis (HP:0100646)	2.07441279
56	Progressive inability to walk (HP:0002505)	2.06559082
57	Azoospermia (HP:0000027)	2.04966973
58	Postaxial foot polydactyly (HP:0001830)	2.04493158
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.03242977
60	Stomatitis (HP:0010280)	2.03049651
61	Abnormal spermatogenesis (HP:0008669)	2.02697953
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01784193
63	B lymphocytopenia (HP:0010976)	1.98849453
64	Thyroid-stimulating hormone excess (HP:0002925)	1.97339400
65	Abnormality of alanine metabolism (HP:0010916)	1.97277265
66	Hyperalaninemia (HP:0003348)	1.97277265
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97277265
68	Stomach cancer (HP:0012126)	1.97191677
69	Astigmatism (HP:0000483)	1.94862404
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94034602
71	Abnormal respiratory epithelium morphology (HP:0012253)	1.94034602
72	Abnormality of the ileum (HP:0001549)	1.93982333
73	Clubbing of toes (HP:0100760)	1.93269099
74	Protruding tongue (HP:0010808)	1.92098037
75	Macular degeneration (HP:0000608)	1.91626108
76	Albinism (HP:0001022)	1.90911153
77	Clumsiness (HP:0002312)	1.90611416
78	Congenital primary aphakia (HP:0007707)	1.90278436
79	Abnormality of T cell physiology (HP:0011840)	1.88192564
80	Gait imbalance (HP:0002141)	1.85592097
81	Oligodactyly (hands) (HP:0001180)	1.85499566
82	Polyuria (HP:0000103)	1.83458948
83	Sloping forehead (HP:0000340)	1.81663634
84	Photophobia (HP:0000613)	1.79492475
85	Scotoma (HP:0000575)	1.79406186
86	Gonadotropin excess (HP:0000837)	1.78183946
87	Male pseudohermaphroditism (HP:0000037)	1.77559966
88	Abnormality of the pubic bones (HP:0003172)	1.77554050
89	Meckel diverticulum (HP:0002245)	1.76643139
90	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.75718366
91	Facial diplegia (HP:0001349)	1.75451517
92	Tubulointerstitial abnormality (HP:0001969)	1.74587912
93	Widely spaced teeth (HP:0000687)	1.74393044
94	Hypoplastic ischia (HP:0003175)	1.73833594
95	Genital tract atresia (HP:0001827)	1.69033577
96	Dialeptic seizures (HP:0011146)	1.68952139
97	Submucous cleft hard palate (HP:0000176)	1.68461493
98	Nephrogenic diabetes insipidus (HP:0009806)	1.67758779
99	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.67053466
100	Hypoplasia of the fovea (HP:0007750)	1.67053466

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.78225473
2	NUAK1	3.17801697
3	MAP4K2	3.09846378
4	ACVR1B	2.86656278
5	PINK1	2.70785764
6	ADRBK2	2.67364207
7	BMPR1B	2.60400036
8	ZAK	2.58354096
9	WNK3	2.57354283
10	INSRR	2.36670777
11	LATS1	2.30852342
12	TAOK3	2.28384773
13	PLK4	2.24981156
14	TXK	2.06881583
15	MAPK13	1.87542998
16	GRK1	1.83579148
17	MAP3K4	1.77869269
18	STK38L	1.61156994
19	MUSK	1.59718567
20	PLK2	1.37650272
21	PIK3CG	1.36154829
22	EIF2AK3	1.33955929
23	TRIM28	1.30827932
24	CASK	1.24586780
25	OXSR1	1.24533606
26	PTK2B	1.16782555
27	NTRK3	1.14497171
28	STK3	1.02359908
29	TEC	1.00828719
30	TNIK	1.00652114
31	AKT3	0.97061277
32	STK39	0.95120045
33	ADRBK1	0.83134129
34	SIK2	0.83110816
35	CSNK1G1	0.80669328
36	MARK3	0.79851607
37	CSNK1A1L	0.79388796
38	MKNK2	0.79248611
39	PNCK	0.77507950
40	MAP2K7	0.76114392
41	PAK3	0.74370446
42	PRKCE	0.73662810
43	BCR	0.72636578
44	STK38	0.69298737
45	CSNK1G3	0.68836292
46	ERBB3	0.66662013
47	CSNK1G2	0.66208413
48	MAPK11	0.65549580
49	IRAK1	0.65375045
50	CDK19	0.64158985
51	TIE1	0.63661120
52	BRD4	0.63395415
53	PRKCQ	0.62405372
54	TNK2	0.60615739
55	FER	0.60342949
56	PKN1	0.60267066
57	IKBKB	0.60239501
58	NEK6	0.59754343
59	TLK1	0.57680002
60	MST4	0.57614132
61	FLT3	0.57371139
62	WNK4	0.57216922
63	KIT	0.53827564
64	BCKDK	0.52934651
65	PRKCG	0.52680502
66	TGFBR1	0.51873896
67	SYK	0.50427749
68	CAMK1G	0.49881504
69	MKNK1	0.48655981
70	DYRK2	0.47726931
71	BLK	0.46134660
72	BRSK2	0.45455871
73	MARK1	0.43826709
74	DAPK2	0.43591156
75	BMPR2	0.42853614
76	PRKAA2	0.42812247
77	OBSCN	0.42725969
78	SGK2	0.40318035
79	PRKG1	0.40274381
80	CSNK1D	0.37574513
81	PDK1	0.37571175
82	DDR2	0.37310094
83	CAMK1	0.36769566
84	PBK	0.36671479
85	CSNK1A1	0.34535386
86	NME1	0.33747717
87	ITK	0.33244727
88	MAP2K1	0.32976182
89	PRKCI	0.32792247
90	ATM	0.32621468
91	CAMK2A	0.31823128
92	IGF1R	0.30529707
93	PRKACA	0.30332086
94	NLK	0.30247415
95	PRKCZ	0.28642608
96	CDK3	0.28500385
97	CHEK2	0.28249586
98	PRKCA	0.27227221
99	CAMKK2	0.26424421
100	PRKACB	0.25928222

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.98857920
2	Butanoate metabolism_Homo sapiens_hsa00650	2.66189600
3	Phototransduction_Homo sapiens_hsa04744	2.62723181
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.48789910
5	Homologous recombination_Homo sapiens_hsa03440	2.34160335
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.21976431
7	Olfactory transduction_Homo sapiens_hsa04740	2.21642152
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13565858
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.13117773
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05861952
11	Nicotine addiction_Homo sapiens_hsa05033	2.05086496
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.01891849
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.98798198
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.95654058
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93962800
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88800294
17	ABC transporters_Homo sapiens_hsa02010	1.84234237
18	Taste transduction_Homo sapiens_hsa04742	1.83379854
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.82954588
20	Propanoate metabolism_Homo sapiens_hsa00640	1.77737618
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.75618998
22	Basal transcription factors_Homo sapiens_hsa03022	1.64805217
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63913654
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.61837620
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.60424508
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.60338951
27	Caffeine metabolism_Homo sapiens_hsa00232	1.55588349
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52450656
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.39458870
30	Morphine addiction_Homo sapiens_hsa05032	1.35124075
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28830145
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27420915
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.21429020
34	Retinol metabolism_Homo sapiens_hsa00830	1.16053232
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14337557
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.10474823
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.09057343
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.08926628
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08451113
40	Serotonergic synapse_Homo sapiens_hsa04726	1.08310719
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06261019
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06027731
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05706550
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.04478191
45	Salivary secretion_Homo sapiens_hsa04970	1.04200063
46	One carbon pool by folate_Homo sapiens_hsa00670	0.96315567
47	Allograft rejection_Homo sapiens_hsa05330	0.93395169
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.93291907
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93225594
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92969290
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92876876
52	RNA polymerase_Homo sapiens_hsa03020	0.92697934
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90408840
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89667347
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87141792
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86366881
57	RNA degradation_Homo sapiens_hsa03018	0.83479978
58	Purine metabolism_Homo sapiens_hsa00230	0.83049955
59	Asthma_Homo sapiens_hsa05310	0.81347798
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80763613
61	Peroxisome_Homo sapiens_hsa04146	0.79744940
62	GABAergic synapse_Homo sapiens_hsa04727	0.77409950
63	Fatty acid degradation_Homo sapiens_hsa00071	0.76880337
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74141831
65	Lysine degradation_Homo sapiens_hsa00310	0.69691681
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.69114692
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67286026
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67200537
69	Histidine metabolism_Homo sapiens_hsa00340	0.66011567
70	Circadian entrainment_Homo sapiens_hsa04713	0.64000174
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62302574
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62224499
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61502936
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.59230605
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58290807
76	RNA transport_Homo sapiens_hsa03013	0.53915117
77	Circadian rhythm_Homo sapiens_hsa04710	0.52624026
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50209386
79	Metabolic pathways_Homo sapiens_hsa01100	0.45455681
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44360200
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.43294420
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43016551
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.41293888
84	Long-term depression_Homo sapiens_hsa04730	0.39786171
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.38643293
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38032654
87	Base excision repair_Homo sapiens_hsa03410	0.37972385
88	Mismatch repair_Homo sapiens_hsa03430	0.36922408
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34753503
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34742367
91	Regulation of autophagy_Homo sapiens_hsa04140	0.33851329
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33511783
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32882699
94	Protein export_Homo sapiens_hsa03060	0.31012037
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29900434
96	Cholinergic synapse_Homo sapiens_hsa04725	0.28948327
97	Glutathione metabolism_Homo sapiens_hsa00480	0.28748572
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28477348
99	Insulin secretion_Homo sapiens_hsa04911	0.28009138
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27888748

GOLGA2P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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