GOLGA2P2Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are two copies of this pseudogene within the P1 palindrome on chromosome Y. This record represents the more centromeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of telomerase activity (GO:0051972)9.38411046
2ventricular trabecula myocardium morphogenesis (GO:0003222)9.25635030
3telomere maintenance via telomerase (GO:0007004)8.33110772
4negative regulation of DNA biosynthetic process (GO:2000279)7.86118438
5DNA damage response, detection of DNA damage (GO:0042769)7.77329393
6regulation of telomere maintenance (GO:0032204)7.72365477
7negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.70292224
8heart trabecula morphogenesis (GO:0061384)7.59486192
9artery development (GO:0060840)6.87789463
10lymphangiogenesis (GO:0001946)6.84390938
11positive regulation of response to oxidative stress (GO:1902884)6.37559724
12positive regulation of cellular response to oxidative stress (GO:1900409)6.37559724
13positive regulation of DNA biosynthetic process (GO:2000573)6.33941979
14RNA-dependent DNA replication (GO:0006278)6.24513925
15embryonic foregut morphogenesis (GO:0048617)6.07722344
16trabecula morphogenesis (GO:0061383)5.93221114
17endothelial cell differentiation (GO:0045446)5.44542005
18cell migration in hindbrain (GO:0021535)5.34702002
19interkinetic nuclear migration (GO:0022027)5.34383886
20response to ischemia (GO:0002931)5.32215831
21renal system development (GO:0072001)5.29292188
22negative regulation of striated muscle cell apoptotic process (GO:0010664)5.27181334
23cell adhesion mediated by integrin (GO:0033627)5.14643121
24regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.93933083
25cardiac right ventricle morphogenesis (GO:0003215)4.92340455
26brain morphogenesis (GO:0048854)4.92057421
27layer formation in cerebral cortex (GO:0021819)4.88208400
28cerebral cortex neuron differentiation (GO:0021895)4.88084623
29hemidesmosome assembly (GO:0031581)4.69559250
30organ growth (GO:0035265)4.68617437
31regulation of cardiac muscle cell apoptotic process (GO:0010665)4.56775855
32activin receptor signaling pathway (GO:0032924)4.54698026
33response to acidic pH (GO:0010447)4.38177869
34superoxide anion generation (GO:0042554)4.25837126
35cellular response to pH (GO:0071467)4.25545299
36protein localization to vacuole (GO:0072665)3.84541231
37protein localization to lysosome (GO:0061462)3.84541231
38heart field specification (GO:0003128)3.82208614
39secondary heart field specification (GO:0003139)3.82208614
40positive regulation of Rho protein signal transduction (GO:0035025)3.80648499
41type B pancreatic cell development (GO:0003323)3.68954382
42gastrulation with mouth forming second (GO:0001702)3.62554985
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.62507116
44NADH dehydrogenase complex assembly (GO:0010257)3.62507116
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62507116
46activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.61476409
47protein polyglutamylation (GO:0018095)3.57292384
48regulation of striated muscle cell apoptotic process (GO:0010662)3.53453985
49pancreas development (GO:0031016)3.48738423
50single strand break repair (GO:0000012)3.36855370
51intra-S DNA damage checkpoint (GO:0031573)3.34512647
52positive regulation of TOR signaling (GO:0032008)3.30323987
53response to increased oxygen levels (GO:0036296)3.23411663
54response to hyperoxia (GO:0055093)3.23411663
55negative regulation of protein localization to cell surface (GO:2000009)3.22483268
56negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20895565
57cell proliferation in forebrain (GO:0021846)3.10630809
58C4-dicarboxylate transport (GO:0015740)3.01594289
59retina development in camera-type eye (GO:0060041)2.98683164
60viral genome replication (GO:0019079)2.97105167
61insulin secretion (GO:0030073)2.93826265
62filopodium assembly (GO:0046847)2.91641575
63histone-serine phosphorylation (GO:0035404)2.88604595
64regulation of DNA biosynthetic process (GO:2000278)2.87875884
65respiratory burst (GO:0045730)2.87501660
66glycerophospholipid catabolic process (GO:0046475)2.84680369
67regulation of protein heterodimerization activity (GO:0043497)2.84506138
68cytoplasmic sequestering of transcription factor (GO:0042994)2.84285092
69cardiac muscle contraction (GO:0060048)2.82508611
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81236204
71nodal signaling pathway (GO:0038092)2.81151510
72nucleus localization (GO:0051647)2.80652169
73exogenous drug catabolic process (GO:0042738)2.80364319
74regulation of smooth muscle cell differentiation (GO:0051150)2.76868646
75DNA replication checkpoint (GO:0000076)2.76404577
76ventricular cardiac muscle cell development (GO:0055015)2.73133467
77nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.60657333
78nucleotide transmembrane transport (GO:1901679)2.60542742
79positive regulation of small GTPase mediated signal transduction (GO:0051057)2.60086261
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59673731
81negative regulation of DNA-templated transcription, elongation (GO:0032785)2.58246321
82response to pH (GO:0009268)2.56106484
83telomere maintenance via telomere lengthening (GO:0010833)2.56058408
84diol metabolic process (GO:0034311)2.55143029
85neuron cell-cell adhesion (GO:0007158)2.54861469
86regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.52813851
87type B pancreatic cell proliferation (GO:0044342)2.50305588
88membrane tubulation (GO:0097320)2.48952515
89positive regulation vascular endothelial growth factor production (GO:0010575)2.48658798
90carnitine shuttle (GO:0006853)2.47444918
91specification of organ identity (GO:0010092)2.46965799
92protein complex biogenesis (GO:0070271)2.46953883
93negative regulation of muscle cell apoptotic process (GO:0010656)2.46750655
94positive regulation of cardiac muscle cell proliferation (GO:0060045)2.44221454
95neuron fate commitment (GO:0048663)2.43057360
96regulation of telomere maintenance via telomerase (GO:0032210)14.8803755
97negative regulation of telomerase activity (GO:0051974)14.2603296
98DNA damage induced protein phosphorylation (GO:0006975)13.4642881
99negative regulation of telomere maintenance (GO:0032205)12.8046024
100regulation of helicase activity (GO:0051095)11.8370762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse8.77988140
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.77516263
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse6.57629234
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse5.20416553
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.88008311
6E2F7_22180533_ChIP-Seq_HELA_Human3.27452225
7GBX2_23144817_ChIP-Seq_PC3_Human3.25883436
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.40349306
9ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.28675305
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.27369264
11ZNF274_21170338_ChIP-Seq_K562_Hela2.16262369
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.13969751
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07307123
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02215985
15TP53_16413492_ChIP-PET_HCT116_Human1.89119726
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75927017
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71590960
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.71391039
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70397274
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.70078307
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.68230107
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67076090
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66519531
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64825542
25TAF15_26573619_Chip-Seq_HEK293_Human1.64468096
26STAT3_23295773_ChIP-Seq_U87_Human1.59776497
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55768831
28REST_21632747_ChIP-Seq_MESCs_Mouse1.51153269
29FUS_26573619_Chip-Seq_HEK293_Human1.46094366
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.45482405
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44734568
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42273772
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.41802829
34MYC_18940864_ChIP-ChIP_HL60_Human1.39001532
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36018523
36CBP_20019798_ChIP-Seq_JUKART_Human1.36018523
37AR_21572438_ChIP-Seq_LNCaP_Human1.34496274
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33535937
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32504600
40IGF1R_20145208_ChIP-Seq_DFB_Human1.32344823
41EWS_26573619_Chip-Seq_HEK293_Human1.28448310
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26682653
43ER_23166858_ChIP-Seq_MCF-7_Human1.26127597
44CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20818298
45LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20235866
46RUNX2_22187159_ChIP-Seq_PCA_Human1.14245403
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12302746
48SOX2_21211035_ChIP-Seq_LN229_Human1.10919029
49SMAD4_21799915_ChIP-Seq_A2780_Human1.08775095
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.08447829
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03154112
52EZH2_22144423_ChIP-Seq_EOC_Human1.02376307
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02067331
54RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00280811
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00150744
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99751367
57NOTCH1_21737748_ChIP-Seq_TLL_Human0.97221550
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96110738
59TCF4_23295773_ChIP-Seq_U87_Human0.96077209
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93401352
61PIAS1_25552417_ChIP-Seq_VCAP_Human0.92589720
62AR_25329375_ChIP-Seq_VCAP_Human0.92500664
63EZH2_27294783_Chip-Seq_ESCs_Mouse0.91974182
64ARNT_22903824_ChIP-Seq_MCF-7_Human0.91390463
65FLI1_21867929_ChIP-Seq_TH2_Mouse0.91238912
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91200964
67TP53_22573176_ChIP-Seq_HFKS_Human0.90958006
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90042464
69TP53_18474530_ChIP-ChIP_U2OS_Human0.89825263
70ERG_21242973_ChIP-ChIP_JURKAT_Human0.89566670
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88706138
72IRF1_19129219_ChIP-ChIP_H3396_Human0.88000288
73SMAD3_21741376_ChIP-Seq_HESCs_Human0.87397597
74ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86804667
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86641045
76TCF4_22108803_ChIP-Seq_LS180_Human0.86000762
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85744234
78ERA_21632823_ChIP-Seq_H3396_Human0.84511917
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84132028
80P300_19829295_ChIP-Seq_ESCs_Human0.83610692
81EST1_17652178_ChIP-ChIP_JURKAT_Human0.80449780
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80173929
83RNF2_27304074_Chip-Seq_NSC_Mouse0.79845857
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79806735
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79067796
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77449486
87RXR_22108803_ChIP-Seq_LS180_Human0.76953346
88NCOR_22424771_ChIP-Seq_293T_Human0.76609779
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76500693
90TBL1_22424771_ChIP-Seq_293T_Human0.76206892
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73639321
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73639321
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73628769
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.72779405
95JUN_21703547_ChIP-Seq_K562_Human0.71510664
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70672196
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.70124994
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.69470068
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69376240
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68536712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia6.39031962
2MP0004133_heterotaxia5.48513958
3MP0002163_abnormal_gland_morphology4.65067170
4MP0003880_abnormal_central_pattern4.54034928
5MP0005646_abnormal_pituitary_gland3.59037880
6MP0002102_abnormal_ear_morphology3.11357143
7MP0002127_abnormal_cardiovascular_syste3.08803049
8MP0006276_abnormal_autonomic_nervous2.97619840
9MP0005379_endocrine/exocrine_gland_phen2.96677184
10MP0004147_increased_porphyrin_level2.92779349
11MP0008775_abnormal_heart_ventricle2.78576403
12MP0005595_abnormal_vascular_smooth2.77894622
13MP0008875_abnormal_xenobiotic_pharmacok2.46877547
14MP0004272_abnormal_basement_membrane2.42110738
15MP0003646_muscle_fatigue2.14599003
16MP0000631_abnormal_neuroendocrine_gland2.00108245
17MP0002734_abnormal_mechanical_nocicepti1.98767206
18MP0009745_abnormal_behavioral_response1.98539155
19MP0003890_abnormal_embryonic-extraembry1.96482360
20MP0009384_cardiac_valve_regurgitation1.88928850
21MP0000778_abnormal_nervous_system1.84769608
22MP0005645_abnormal_hypothalamus_physiol1.80897401
23MP0000647_abnormal_sebaceous_gland1.73661794
24MP0002876_abnormal_thyroid_physiology1.65185325
25MP0001485_abnormal_pinna_reflex1.63316557
26MP0004883_abnormal_blood_vessel1.57295620
27MP0003195_calcinosis1.57186479
28MP0002064_seizures1.56675921
29MP0001529_abnormal_vocalization1.54982153
30MP0003763_abnormal_thymus_physiology1.48936158
31MP0009697_abnormal_copulation1.41607959
32MP0006072_abnormal_retinal_apoptosis1.40224434
33MP0003806_abnormal_nucleotide_metabolis1.33962055
34MP0008995_early_reproductive_senescence1.32257890
35MP0003635_abnormal_synaptic_transmissio1.20337664
36MP0000749_muscle_degeneration1.18044664
37MP0005551_abnormal_eye_electrophysiolog1.17485468
38MP0003122_maternal_imprinting1.15693228
39MP0003787_abnormal_imprinting1.12823133
40MP0005620_abnormal_muscle_contractility1.12089365
41MP0004811_abnormal_neuron_physiology1.10996406
42MP0000230_abnormal_systemic_arterial1.09697362
43MP0002168_other_aberrant_phenotype1.09468540
44MP0002063_abnormal_learning/memory/cond1.08728325
45MP0002557_abnormal_social/conspecific_i1.06909184
46MP0009250_abnormal_appendicular_skeleto1.05049980
47MP0005330_cardiomyopathy1.03860860
48MP0008877_abnormal_DNA_methylation1.02538836
49MP0002089_abnormal_postnatal_growth/wei1.01017382
50MP0002233_abnormal_nose_morphology1.00243933
51MP0002972_abnormal_cardiac_muscle0.99522828
52MP0005195_abnormal_posterior_eye0.99479785
53MP0005386_behavior/neurological_phenoty0.98490693
54MP0004924_abnormal_behavior0.98490693
55MP0004145_abnormal_muscle_electrophysio0.97252580
56MP0000427_abnormal_hair_cycle0.96182093
57MP0003283_abnormal_digestive_organ0.96092296
58MP0004484_altered_response_of0.94472289
59MP0001968_abnormal_touch/_nociception0.92503351
60MP0000249_abnormal_blood_vessel0.90908488
61MP0008874_decreased_physiological_sensi0.90899910
62MP0001963_abnormal_hearing_physiology0.90016079
63MP0000920_abnormal_myelination0.89089916
64MP0001919_abnormal_reproductive_system0.87937458
65MP0002736_abnormal_nociception_after0.87365589
66MP0003221_abnormal_cardiomyocyte_apopto0.85762708
67MP0005647_abnormal_sex_gland0.85413213
68MP0000343_altered_response_to0.85302361
69MP0005448_abnormal_energy_balance0.85180084
70MP0002572_abnormal_emotion/affect_behav0.83204297
71MP0003693_abnormal_embryo_hatching0.80300116
72MP0004742_abnormal_vestibular_system0.79825552
73MP0002111_abnormal_tail_morphology0.78967826
74MP0003638_abnormal_response/metabolism_0.77673105
75MP0009672_abnormal_birth_weight0.77387145
76MP0010329_abnormal_lipoprotein_level0.77212666
77MP0005385_cardiovascular_system_phenoty0.76403083
78MP0001544_abnormal_cardiovascular_syste0.76403083
79MP0003448_altered_tumor_morphology0.73774358
80MP0005197_abnormal_uvea_morphology0.73188186
81MP0002272_abnormal_nervous_system0.71587374
82MP0009046_muscle_twitch0.71568353
83MP0003938_abnormal_ear_development0.70351630
84MP0002733_abnormal_thermal_nociception0.70318557
85MP0000566_synostosis0.65253139
86MP0002184_abnormal_innervation0.64801878
87MP0003137_abnormal_impulse_conducting0.64574925
88MP0008057_abnormal_DNA_replication0.63299016
89MP0003755_abnormal_palate_morphology0.61405361
90MP0005253_abnormal_eye_physiology0.60642458
91MP0003075_altered_response_to0.60487234
92MP0001970_abnormal_pain_threshold0.60282583
93MP0002751_abnormal_autonomic_nervous0.59802925
94MP0000465_gastrointestinal_hemorrhage0.59774923
95MP0003861_abnormal_nervous_system0.59529669
96MP0003948_abnormal_gas_homeostasis0.58703725
97MP0000049_abnormal_middle_ear0.58122109
98MP0003121_genomic_imprinting0.58083842
99MP0005389_reproductive_system_phenotype0.57946397
100MP0002882_abnormal_neuron_morphology0.56554839

Predicted human phenotypes

RankGene SetZ-score
1Esophageal atresia (HP:0002032)9.62586530
2Abnormality of the aortic arch (HP:0012303)8.93226234
3Aplasia cutis congenita (HP:0001057)7.93998894
4Increased serum pyruvate (HP:0003542)6.91004284
5Gastrointestinal atresia (HP:0002589)6.03749541
6Abnormality of glycolysis (HP:0004366)5.86001020
7Milia (HP:0001056)5.02466607
8Increased connective tissue (HP:0009025)5.02228642
9Ureteral stenosis (HP:0000071)4.97316904
10Ureteral obstruction (HP:0006000)4.64178897
11Atrophic scars (HP:0001075)4.60413817
12Chronic hepatic failure (HP:0100626)4.46666145
13Hypokinesia (HP:0002375)4.42198458
14Fragile skin (HP:0001030)4.38599699
15Pterygium (HP:0001059)4.21406550
16Hyperventilation (HP:0002883)3.99606681
17Abnormality of midbrain morphology (HP:0002418)3.67659697
18Molar tooth sign on MRI (HP:0002419)3.67659697
19Ectropion (HP:0000656)3.53735749
20Atrioventricular canal defect (HP:0006695)3.48702958
21Curly hair (HP:0002212)3.48218914
22Atonic seizures (HP:0010819)3.36303197
23Melanoma (HP:0002861)3.36262905
24Freckling (HP:0001480)3.31770079
25Recurrent corneal erosions (HP:0000495)3.30603354
26Ragged-red muscle fibers (HP:0003200)3.29207056
27High anterior hairline (HP:0009890)3.25156738
28Amblyopia (HP:0000646)3.19800860
29Tetraplegia (HP:0002445)3.19109528
30Small intestinal stenosis (HP:0012848)2.87662193
31Duodenal stenosis (HP:0100867)2.87662193
32Tubulointerstitial nephritis (HP:0001970)2.82248580
33Nephronophthisis (HP:0000090)2.74771365
34Blue irides (HP:0000635)2.65693690
35Neoplasm of the pancreas (HP:0002894)2.65285995
36Retinopathy (HP:0000488)2.60932817
37Diminished movement (HP:0002374)2.59318234
38Abnormality of the labia minora (HP:0012880)2.47842730
39True hermaphroditism (HP:0010459)2.44119964
40Abnormality of the prostate (HP:0008775)2.43408312
41Rimmed vacuoles (HP:0003805)2.34659818
42Abnormality of the duodenum (HP:0002246)2.33717989
43Status epilepticus (HP:0002133)2.33461456
44Hypoplasia of dental enamel (HP:0006297)2.32799578
45Hepatocellular necrosis (HP:0001404)2.30094913
46Inability to walk (HP:0002540)2.28379270
47Abnormality of the renal medulla (HP:0100957)2.27275292
48Patellar aplasia (HP:0006443)2.22197885
49Cystic hygroma (HP:0000476)2.14845991
50Aplasia/Hypoplasia of the patella (HP:0006498)2.09621473
51CNS demyelination (HP:0007305)2.09056993
52Absent speech (HP:0001344)2.07331376
53Increased CSF lactate (HP:0002490)2.06598039
54Pancreatic cysts (HP:0001737)2.06242751
55Colon cancer (HP:0003003)2.00768518
56Focal seizures (HP:0007359)2.00423765
57Hypsarrhythmia (HP:0002521)1.99754611
58Broad-based gait (HP:0002136)1.98641113
59Redundant skin (HP:0001582)1.93731048
60Hepatic necrosis (HP:0002605)1.90262753
61EEG with generalized epileptiform discharges (HP:0011198)1.90128151
62Fair hair (HP:0002286)1.89452001
63Broad metatarsal (HP:0001783)1.88338630
64Impaired pain sensation (HP:0007328)1.88310715
65Abnormality of pain sensation (HP:0010832)1.88310715
66Attenuation of retinal blood vessels (HP:0007843)1.88094944
67Dialeptic seizures (HP:0011146)1.88069848
68Epileptiform EEG discharges (HP:0011182)1.83962312
69Pancreatic fibrosis (HP:0100732)1.83933754
70Humeroradial synostosis (HP:0003041)1.83275900
71Synostosis involving the elbow (HP:0003938)1.83275900
72Hip dysplasia (HP:0001385)1.82966444
73Retinal atrophy (HP:0001105)1.81354128
74Optic nerve hypoplasia (HP:0000609)1.80320996
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.78063505
76Clumsiness (HP:0002312)1.77871169
77Heterochromia iridis (HP:0001100)1.77205726
78Absence seizures (HP:0002121)1.75975767
79Chorioretinal coloboma (HP:0000567)1.75832994
80Exotropia (HP:0000577)1.73211499
81Shoulder girdle muscle weakness (HP:0003547)1.71435284
82Abnormality of the intervertebral disk (HP:0005108)1.71127425
83Male infertility (HP:0003251)1.67940722
84Broad distal phalanx of finger (HP:0009836)1.67175736
85Large earlobe (HP:0009748)1.66975033
86Xanthomatosis (HP:0000991)1.66159174
87Occipital encephalocele (HP:0002085)1.65583697
88Hypoplasia of the fovea (HP:0007750)1.64619135
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.64619135
90Generalized myoclonic seizures (HP:0002123)1.64433187
91Spinal cord lesions (HP:0100561)1.61951671
92Syringomyelia (HP:0003396)1.61951671
93Anonychia (HP:0001798)1.60599194
94Abnormality of the musculature of the pelvis (HP:0001469)1.59640854
95Abnormality of the hip-girdle musculature (HP:0001445)1.59640854
96Abnormality of male internal genitalia (HP:0000022)1.58197907
97Scrotal hypoplasia (HP:0000046)1.56139533
98Congenital sensorineural hearing impairment (HP:0008527)1.52080388
99Thickened nuchal skin fold (HP:0000474)1.49730937
100Generalized tonic-clonic seizures (HP:0002069)1.49564553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K66.20470772
2TLK15.48800507
3MAP3K53.75787282
4MAP4K23.59797012
5SIK23.16255800
6TAOK212.3927802
7MAPKAPK31.86688159
8EEF2K1.76601472
9NME11.75947734
10INSRR1.62205851
11MAP3K81.56031430
12RIPK11.51284218
13FRK1.32733880
14CASK1.15699921
15PIK3CA0.94330235
16MAPKAPK50.94178680
17TRPM70.82397978
18OXSR10.78744769
19EPHB10.75110666
20MAPK130.72309547
21WNK40.71689004
22TRIM280.71297895
23EPHA30.68291805
24BCR0.68166432
25STK390.67748326
26CSNK1G30.65084817
27CSNK1A1L0.58761636
28FGFR20.58755686
29RIPK40.57918809
30MAP2K70.56439258
31CSNK1G20.55881416
32WNK30.55175034
33MAP3K40.53186022
34CSNK1G10.49068997
35RPS6KB20.48418800
36MELK0.48275047
37CCNB10.42402124
38SIK30.40121045
39HIPK20.39472785
40MARK10.36038147
41ADRBK20.29670270
42TTK0.28671222
43PINK10.28248792
44TNIK0.26653230
45PRKCG0.23099338
46MINK10.23084927
47NLK0.22883846
48MAPK70.18621748
49EPHA40.18135602
50PRKAA20.17508116
51PRKCZ0.17005461
52DYRK20.16987293
53PLK40.16454815
54TAF10.16418121
55MAPK110.14886041
56MARK30.14324049
57CSNK1A10.14137541
58CDK50.12980497
59MAP3K70.10624828
60AURKA0.09835338
61PAK30.09670420
62STK40.09650958
63BMPR1B0.09404830
64VRK20.08235181
65PRKAA10.08149282
66TAOK30.07389291
67ATR0.06946907
68PRKACB0.06834732
69STK110.06691983
70ADRBK10.06407999
71GRK10.06241379
72NUAK10.05377103
73RPS6KB10.05349972
74YES10.05003720
75PRKCQ0.04989035
76PDK10.04163092
77PHKG10.03161046
78PHKG20.03161046
79FGR0.02435359
80CHEK20.02183000
81CSNK1D0.01556171
82CDK80.01247189
83CSNK2A10.00360279
84OBSCN0.00297185
85MAPK9-0.0276949
86CDK1-0.0228819
87GRK5-0.0225355
88MUSK-0.0221144
89PRKD1-0.0201063
90DDR2-0.0198095
91PTK2B-0.0179201
92ATM-0.0177409
93WEE1-0.0151162
94PDPK1-0.0108121
95MAPK8-0.0087578
96PLK2-0.0086727
97MST4-0.0085237
98MAPK15-0.0072224
99MARK2-0.0065946
100RET-0.0008021

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004305.46716361
2Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050143.73730530
3Cocaine addiction_Homo sapiens_hsa050303.27465163
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046643.14196047
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.85884992
6Butanoate metabolism_Homo sapiens_hsa006502.72835109
7GnRH signaling pathway_Homo sapiens_hsa049122.70142408
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.52620982
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10184676
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.05632399
11Toxoplasmosis_Homo sapiens_hsa051451.98373304
12Nicotine addiction_Homo sapiens_hsa050331.84896729
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73479595
14Phototransduction_Homo sapiens_hsa047441.71149048
15Dorso-ventral axis formation_Homo sapiens_hsa043201.63849086
16Dilated cardiomyopathy_Homo sapiens_hsa054141.59665053
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57794573
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52425813
19Selenocompound metabolism_Homo sapiens_hsa004501.52403769
20Fanconi anemia pathway_Homo sapiens_hsa034601.39565294
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.36950327
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32785685
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21788857
24Regulation of autophagy_Homo sapiens_hsa041401.21502991
25TGF-beta signaling pathway_Homo sapiens_hsa043501.18190133
26GABAergic synapse_Homo sapiens_hsa047271.15913281
27Oxidative phosphorylation_Homo sapiens_hsa001901.15730201
28Salivary secretion_Homo sapiens_hsa049701.08126473
29Histidine metabolism_Homo sapiens_hsa003401.07934144
30TNF signaling pathway_Homo sapiens_hsa046681.06525669
31Influenza A_Homo sapiens_hsa051641.06317509
32Circadian rhythm_Homo sapiens_hsa047101.04831004
33Parkinsons disease_Homo sapiens_hsa050121.04754492
34Caffeine metabolism_Homo sapiens_hsa002321.04458322
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03509112
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01985869
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.00569111
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.00307487
39Circadian entrainment_Homo sapiens_hsa047130.99675353
40Osteoclast differentiation_Homo sapiens_hsa043800.97072020
41Rap1 signaling pathway_Homo sapiens_hsa040150.94818055
42Alzheimers disease_Homo sapiens_hsa050100.92862810
43Ether lipid metabolism_Homo sapiens_hsa005650.92005501
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86740164
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84184173
46ECM-receptor interaction_Homo sapiens_hsa045120.83869527
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82205689
48Olfactory transduction_Homo sapiens_hsa047400.82076147
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80511549
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80225570
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78941674
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70378396
53Pyrimidine metabolism_Homo sapiens_hsa002400.68832757
54Sphingolipid metabolism_Homo sapiens_hsa006000.67082221
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66798234
56Endometrial cancer_Homo sapiens_hsa052130.66343879
57Taste transduction_Homo sapiens_hsa047420.66120747
58Glutamatergic synapse_Homo sapiens_hsa047240.65376177
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64324984
60Glycerolipid metabolism_Homo sapiens_hsa005610.62146971
61Morphine addiction_Homo sapiens_hsa050320.59586525
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59489229
63Oxytocin signaling pathway_Homo sapiens_hsa049210.57975966
64Linoleic acid metabolism_Homo sapiens_hsa005910.55082503
65Basal cell carcinoma_Homo sapiens_hsa052170.53740317
66Fatty acid elongation_Homo sapiens_hsa000620.51966400
67Amphetamine addiction_Homo sapiens_hsa050310.49365753
68beta-Alanine metabolism_Homo sapiens_hsa004100.49089323
69Hematopoietic cell lineage_Homo sapiens_hsa046400.47838473
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47094012
71Chemical carcinogenesis_Homo sapiens_hsa052040.47062371
72Systemic lupus erythematosus_Homo sapiens_hsa053220.45812508
73Retinol metabolism_Homo sapiens_hsa008300.45633815
74Alcoholism_Homo sapiens_hsa050340.45445634
75Glucagon signaling pathway_Homo sapiens_hsa049220.45012480
76Cardiac muscle contraction_Homo sapiens_hsa042600.44946186
77Small cell lung cancer_Homo sapiens_hsa052220.43472094
78MAPK signaling pathway_Homo sapiens_hsa040100.41426748
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40640319
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37555178
81Axon guidance_Homo sapiens_hsa043600.37530483
82Purine metabolism_Homo sapiens_hsa002300.37267137
83Ovarian steroidogenesis_Homo sapiens_hsa049130.37038039
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36897835
85cAMP signaling pathway_Homo sapiens_hsa040240.35726778
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35457882
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.35424090
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35233567
89Gastric acid secretion_Homo sapiens_hsa049710.35157935
90Basal transcription factors_Homo sapiens_hsa030220.34035743
91MicroRNAs in cancer_Homo sapiens_hsa052060.33510778
92ErbB signaling pathway_Homo sapiens_hsa040120.32375900
93Homologous recombination_Homo sapiens_hsa034400.31400415
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30822787
95RNA polymerase_Homo sapiens_hsa030200.30634701
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30616715
97Arachidonic acid metabolism_Homo sapiens_hsa005900.30474193
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29485535
99FoxO signaling pathway_Homo sapiens_hsa040680.28878715
100Calcium signaling pathway_Homo sapiens_hsa040200.27876760

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