ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.36333700
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.68827524
3	cilium movement (GO:0003341)	8.39012341
4	epithelial cilium movement (GO:0003351)	7.14282740
5	motile cilium assembly (GO:0044458)	6.95809989
6	axoneme assembly (GO:0035082)	6.18437235
7	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.78694454
8	left/right axis specification (GO:0070986)	4.55945611
9	negative regulation of cAMP-mediated signaling (GO:0043951)	4.55504577
10	cilium organization (GO:0044782)	3.95509256
11	monoubiquitinated protein deubiquitination (GO:0035520)	3.94424901
12	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.92483326
13	negative regulation of B cell mediated immunity (GO:0002713)	3.92483326
14	drug catabolic process (GO:0042737)	3.90334082
15	regulation of cilium movement (GO:0003352)	3.89351933
16	cilium assembly (GO:0042384)	3.82267132
17	exogenous drug catabolic process (GO:0042738)	3.81835551
18	behavioral response to ethanol (GO:0048149)	3.61643003
19	indolalkylamine catabolic process (GO:0046218)	3.59644426
20	tryptophan catabolic process (GO:0006569)	3.59644426
21	indole-containing compound catabolic process (GO:0042436)	3.59644426
22	ventricular system development (GO:0021591)	3.54076425
23	photoreceptor cell maintenance (GO:0045494)	3.52025492
24	indolalkylamine metabolic process (GO:0006586)	3.51096953
25	vitamin transmembrane transport (GO:0035461)	3.47773719
26	negative regulation of humoral immune response (GO:0002921)	3.41271908
27	interkinetic nuclear migration (GO:0022027)	3.40606920
28	cilium morphogenesis (GO:0060271)	3.36860653
29	intraciliary transport (GO:0042073)	3.36444909
30	neural tube formation (GO:0001841)	3.32602080
31	regulation of acrosome reaction (GO:0060046)	3.31577441
32	left/right pattern formation (GO:0060972)	3.28387103
33	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.26125017
34	regulation of protein glycosylation (GO:0060049)	3.25456154
35	microtubule bundle formation (GO:0001578)	3.13407380
36	cellular component assembly involved in morphogenesis (GO:0010927)	3.07727513
37	piRNA metabolic process (GO:0034587)	3.05240933
38	cellular ketone body metabolic process (GO:0046950)	3.03949142
39	tryptophan metabolic process (GO:0006568)	2.98410624
40	retinal cone cell development (GO:0046549)	2.97034499
41	opioid receptor signaling pathway (GO:0038003)	2.96270735
42	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.95231991
43	sphingoid metabolic process (GO:0046519)	2.93823906
44	regulation of hippo signaling (GO:0035330)	2.92952942
45	centriole assembly (GO:0098534)	2.92711386
46	one-carbon compound transport (GO:0019755)	2.92601389
47	establishment of protein localization to Golgi (GO:0072600)	2.91001359
48	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.90232484
49	histone H3-K4 trimethylation (GO:0080182)	2.90080543
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88627716
51	protein localization to cilium (GO:0061512)	2.87978992
52	cornea development in camera-type eye (GO:0061303)	2.87576071
53	thyroid hormone metabolic process (GO:0042403)	2.86159635
54	striated muscle atrophy (GO:0014891)	2.85394336
55	ethanol metabolic process (GO:0006067)	2.84221243
56	kynurenine metabolic process (GO:0070189)	2.81232423
57	protein K48-linked deubiquitination (GO:0071108)	2.78065803
58	phosphatidylethanolamine metabolic process (GO:0046337)	2.76655983
59	snRNA transcription (GO:0009301)	2.75963144
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.75558308
61	detection of light stimulus involved in visual perception (GO:0050908)	2.75558308
62	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.73626989
63	regulation of translation, ncRNA-mediated (GO:0045974)	2.73626989
64	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.73626989
65	benzene-containing compound metabolic process (GO:0042537)	2.72714093
66	protein K11-linked deubiquitination (GO:0035871)	2.71017037
67	epoxygenase P450 pathway (GO:0019373)	2.69500207
68	sperm motility (GO:0030317)	2.68506626
69	histone H3-K9 modification (GO:0061647)	2.67425887
70	cell projection assembly (GO:0030031)	2.65400940
71	fucose catabolic process (GO:0019317)	2.64599203
72	L-fucose metabolic process (GO:0042354)	2.64599203
73	L-fucose catabolic process (GO:0042355)	2.64599203
74	histone H3-K36 demethylation (GO:0070544)	2.64510930
75	centriole replication (GO:0007099)	2.64135267
76	tolerance induction (GO:0002507)	2.63650823
77	flavonoid metabolic process (GO:0009812)	2.63074678
78	cellular response to ethanol (GO:0071361)	2.61398343
79	ketone body metabolic process (GO:1902224)	2.60331638
80	negative regulation of complement activation (GO:0045916)	2.59535121
81	histone H3-K9 methylation (GO:0051567)	2.57871665
82	nucleus localization (GO:0051647)	2.54436968
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.53111726
84	rRNA catabolic process (GO:0016075)	2.52670688
85	adult feeding behavior (GO:0008343)	2.52568301
86	positive regulation of developmental pigmentation (GO:0048087)	2.52052412
87	negative regulation of protein activation cascade (GO:2000258)	2.51831501
88	regulation of posttranscriptional gene silencing (GO:0060147)	2.51540490
89	regulation of gene silencing by miRNA (GO:0060964)	2.51540490
90	regulation of gene silencing by RNA (GO:0060966)	2.51540490
91	oxidative demethylation (GO:0070989)	2.50603425
92	skeletal muscle adaptation (GO:0043501)	2.48347737
93	regulation of establishment of cell polarity (GO:2000114)	2.47816972
94	glomerular epithelial cell development (GO:0072310)	2.47803129
95	microtubule-based movement (GO:0007018)	2.46720421
96	primary alcohol catabolic process (GO:0034310)	2.43597267
97	ncRNA catabolic process (GO:0034661)	2.43450265
98	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.42744620
99	diterpenoid biosynthetic process (GO:0016102)	2.39613331
100	cilium or flagellum-dependent cell motility (GO:0001539)	11.0330911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.84079450
2	VDR_22108803_ChIP-Seq_LS180_Human	2.81360540
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.76431584
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58899449
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.33810791
6	DROSHA_22980978_ChIP-Seq_HELA_Human	2.31671502
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19349953
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07428501
9	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.04419457
10	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.00311781
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.00125194
12	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98938587
13	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98938587
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.94649606
15	STAT3_23295773_ChIP-Seq_U87_Human	1.94431867
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92130763
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.87349459
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86278607
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85462621
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.85423105
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85108339
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80002632
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.76621053
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.76033404
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.75696676
26	TCF4_23295773_ChIP-Seq_U87_Human	1.74124115
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.72691920
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69040261
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65545582
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61732366
31	AHR_22903824_ChIP-Seq_MCF-7_Human	1.60876966
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57576478
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56412057
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54077774
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.51948618
36	TP53_16413492_ChIP-PET_HCT116_Human	1.51536375
37	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.50597084
38	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.49841868
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.49457370
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49457370
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47855769
42	P300_19829295_ChIP-Seq_ESCs_Human	1.44901193
43	RXR_22108803_ChIP-Seq_LS180_Human	1.44682258
44	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.41581401
45	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.40880098
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40520522
47	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.39611182
48	FUS_26573619_Chip-Seq_HEK293_Human	1.36294102
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.35306300
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33633334
51	EWS_26573619_Chip-Seq_HEK293_Human	1.33032774
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32300056
53	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.31930078
54	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.29338502
55	AR_25329375_ChIP-Seq_VCAP_Human	1.28898974
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28607520
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28092819
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27105270
59	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.26485316
60	CDX2_22108803_ChIP-Seq_LS180_Human	1.25641796
61	RUNX_20019798_ChIP-Seq_JUKART_Human	1.23968138
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23938888
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23749971
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22238574
65	SMRT_27268052_Chip-Seq_Bcells_Human	1.21672077
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21519274
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20931326
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20810633
69	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.20650872
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19861938
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19685732
72	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.19290898
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16274098
74	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14203134
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11716282
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11706288
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09930891
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09827451
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09003735
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09003735
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06948766
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06452061
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.05396319
84	TP63_23658742_ChIP-Seq_EP156T_Human	1.02825603
85	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01605989
86	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01121419
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99364234
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99156514
89	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98954929
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98793478
91	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98752987
92	AR_19668381_ChIP-Seq_PC3_Human	0.98194433
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98153763
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97534183
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96902301
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96808334
97	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96333164
98	TBL1_22424771_ChIP-Seq_293T_Human	0.95922998
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95732099
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94556041

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.92485768
2	MP0003195_calcinosis	3.87978441
3	MP0004043_abnormal_pH_regulation	3.55238195
4	MP0002653_abnormal_ependyma_morphology	3.15001575
5	MP0002876_abnormal_thyroid_physiology	3.11111208
6	MP0008875_abnormal_xenobiotic_pharmacok	3.10652453
7	MP0005551_abnormal_eye_electrophysiolog	2.36364961
8	MP0003045_fibrosis	2.33150720
9	MP0005360_urolithiasis	2.21784003
10	MP0002168_other_aberrant_phenotype	2.20178751
11	MP0009780_abnormal_chondrocyte_physiolo	2.19872065
12	MP0002132_abnormal_respiratory_system	2.16079321
13	MP0000569_abnormal_digit_pigmentation	2.07605657
14	MP0005646_abnormal_pituitary_gland	2.04220494
15	MP0005085_abnormal_gallbladder_physiolo	2.03193457
16	MP0000383_abnormal_hair_follicle	1.99597559
17	MP0001501_abnormal_sleep_pattern	1.79613076
18	MP0005310_abnormal_salivary_gland	1.79273495
19	MP0003136_yellow_coat_color	1.77288896
20	MP0003252_abnormal_bile_duct	1.76794503
21	MP0002138_abnormal_hepatobiliary_system	1.69279570
22	MP0002928_abnormal_bile_duct	1.65638945
23	MP0005377_hearing/vestibular/ear_phenot	1.63147962
24	MP0003878_abnormal_ear_physiology	1.63147962
25	MP0001968_abnormal_touch/_nociception	1.61267171
26	MP0008877_abnormal_DNA_methylation	1.59619438
27	MP0003763_abnormal_thymus_physiology	1.58625980
28	MP0003183_abnormal_peptide_metabolism	1.54551842
29	MP0003646_muscle_fatigue	1.49851936
30	MP0005395_other_phenotype	1.47134508
31	MP0000427_abnormal_hair_cycle	1.44871825
32	MP0009046_muscle_twitch	1.44397305
33	MP0004133_heterotaxia	1.39833032
34	MP0001485_abnormal_pinna_reflex	1.39822047
35	MP0008872_abnormal_physiological_respon	1.39145173
36	MP0010678_abnormal_skin_adnexa	1.30341115
37	MP0008961_abnormal_basal_metabolism	1.29931032
38	MP0002160_abnormal_reproductive_system	1.29210799
39	MP0001984_abnormal_olfaction	1.28386052
40	MP0005645_abnormal_hypothalamus_physiol	1.25126337
41	MP0009278_abnormal_bone_marrow	1.21743643
42	MP0002277_abnormal_respiratory_mucosa	1.21669179
43	MP0001986_abnormal_taste_sensitivity	1.19031787
44	MP0003698_abnormal_male_reproductive	1.18845291
45	MP0005365_abnormal_bile_salt	1.18787563
46	MP0008995_early_reproductive_senescence	1.17754734
47	MP0003943_abnormal_hepatobiliary_system	1.17707826
48	MP0001765_abnormal_ion_homeostasis	1.15012360
49	MP0003787_abnormal_imprinting	1.13816580
50	MP0005083_abnormal_biliary_tract	1.11223979
51	MP0010329_abnormal_lipoprotein_level	1.11159485
52	MP0001929_abnormal_gametogenesis	1.09024444
53	MP0005389_reproductive_system_phenotype	1.08393757
54	MP0001873_stomach_inflammation	1.08150285
55	MP0003890_abnormal_embryonic-extraembry	1.08033531
56	MP0004381_abnormal_hair_follicle	1.06485936
57	MP0001666_abnormal_nutrient_absorption	1.06412436
58	MP0000631_abnormal_neuroendocrine_gland	1.05904969
59	MP0001664_abnormal_digestion	1.02221071
60	MP0001486_abnormal_startle_reflex	0.98541298
61	MP0002693_abnormal_pancreas_physiology	0.97197768
62	MP0005220_abnormal_exocrine_pancreas	0.96991482
63	MP0004264_abnormal_extraembryonic_tissu	0.96310145
64	MP0001800_abnormal_humoral_immune	0.95364645
65	MP0005253_abnormal_eye_physiology	0.95125487
66	MP0004019_abnormal_vitamin_homeostasis	0.92648471
67	MP0002229_neurodegeneration	0.91556168
68	MP0003879_abnormal_hair_cell	0.91264628
69	MP0009745_abnormal_behavioral_response	0.90069539
70	MP0005174_abnormal_tail_pigmentation	0.89843427
71	MP0003950_abnormal_plasma_membrane	0.87884325
72	MP0005195_abnormal_posterior_eye	0.84844270
73	MP0002136_abnormal_kidney_physiology	0.84355548
74	MP0002638_abnormal_pupillary_reflex	0.84162841
75	MP0001324_abnormal_eye_pigmentation	0.82565630
76	MP0003656_abnormal_erythrocyte_physiolo	0.82524719
77	MP0002249_abnormal_larynx_morphology	0.81876784
78	MP0009643_abnormal_urine_homeostasis	0.79928211
79	MP0000678_abnormal_parathyroid_gland	0.79408075
80	MP0000685_abnormal_immune_system	0.79085281
81	MP0002139_abnormal_hepatobiliary_system	0.75995014
82	MP0005387_immune_system_phenotype	0.75162011
83	MP0001790_abnormal_immune_system	0.75162011
84	MP0001270_distended_abdomen	0.74565587
85	MP0000015_abnormal_ear_pigmentation	0.73858568
86	MP0001764_abnormal_homeostasis	0.73709970
87	MP0004130_abnormal_muscle_cell	0.72811180
88	MP0000681_abnormal_thyroid_gland	0.70742565
89	MP0006292_abnormal_olfactory_placode	0.69806802
90	MP0003718_maternal_effect	0.69687061
91	MP0001756_abnormal_urination	0.69357894
92	MP0003633_abnormal_nervous_system	0.69212448
93	MP0002557_abnormal_social/conspecific_i	0.68694328
94	MP0009764_decreased_sensitivity_to	0.67124666
95	MP0002210_abnormal_sex_determination	0.65841793
96	MP0004142_abnormal_muscle_tone	0.65629419
97	MP0002405_respiratory_system_inflammati	0.65605031
98	MP0004742_abnormal_vestibular_system	0.65521111
99	MP0003953_abnormal_hormone_level	0.65406624
100	MP0005671_abnormal_response_to	0.65312237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.63744352
2	Absent/shortened dynein arms (HP:0200106)	7.39012261
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.39012261
4	Abnormal ciliary motility (HP:0012262)	7.17375291
5	Abnormal respiratory epithelium morphology (HP:0012253)	7.03668248
6	Abnormal respiratory motile cilium morphology (HP:0005938)	7.03668248
7	Abnormal respiratory motile cilium physiology (HP:0012261)	6.98969500
8	Rhinitis (HP:0012384)	6.20808972
9	Bronchiectasis (HP:0002110)	5.06543204
10	Chronic bronchitis (HP:0004469)	4.70907448
11	Pancreatic fibrosis (HP:0100732)	4.14667168
12	Pancreatic cysts (HP:0001737)	4.07740094
13	True hermaphroditism (HP:0010459)	3.96443386
14	Chronic hepatic failure (HP:0100626)	3.75343457
15	Molar tooth sign on MRI (HP:0002419)	3.55914560
16	Abnormality of midbrain morphology (HP:0002418)	3.55914560
17	Cystic liver disease (HP:0006706)	3.53112182
18	Nasal polyposis (HP:0100582)	3.46290684
19	Nephronophthisis (HP:0000090)	3.31297970
20	Bronchitis (HP:0012387)	3.31183949
21	Thyroid-stimulating hormone excess (HP:0002925)	3.29296885
22	Recurrent sinusitis (HP:0011108)	3.27940115
23	Abnormality of the renal medulla (HP:0100957)	3.07823539
24	Tubular atrophy (HP:0000092)	2.95495524
25	Gaze-evoked nystagmus (HP:0000640)	2.90757020
26	Chronic sinusitis (HP:0011109)	2.87054661
27	Decreased circulating renin level (HP:0003351)	2.86620507
28	Genetic anticipation (HP:0003743)	2.68799658
29	Abnormality of the renal cortex (HP:0011035)	2.68005140
30	Recurrent otitis media (HP:0000403)	2.62885855
31	Occipital encephalocele (HP:0002085)	2.61718808
32	Hyperactive renin-angiotensin system (HP:0000841)	2.54288136
33	Abnormality of the nasal mucosa (HP:0000433)	2.51993917
34	Tubulointerstitial nephritis (HP:0001970)	2.49158825
35	Infertility (HP:0000789)	2.44103092
36	Postaxial foot polydactyly (HP:0001830)	2.38466141
37	Volvulus (HP:0002580)	2.38434697
38	Hyperventilation (HP:0002883)	2.38145584
39	Congenital hepatic fibrosis (HP:0002612)	2.36050040
40	Recurrent bronchitis (HP:0002837)	2.35124043
41	Attenuation of retinal blood vessels (HP:0007843)	2.34454782
42	Intestinal atresia (HP:0011100)	2.25315737
43	Decreased central vision (HP:0007663)	2.25096151
44	Chronic otitis media (HP:0000389)	2.23508392
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20958891
46	Male pseudohermaphroditism (HP:0000037)	2.13405592
47	Anencephaly (HP:0002323)	2.08529749
48	Progressive cerebellar ataxia (HP:0002073)	2.07164613
49	Polydipsia (HP:0001959)	2.05018292
50	Abnormal drinking behavior (HP:0030082)	2.05018292
51	Medial flaring of the eyebrow (HP:0010747)	2.04048820
52	Hyperkalemia (HP:0002153)	2.03513469
53	Large for gestational age (HP:0001520)	2.03324381
54	Abnormality of renin-angiotensin system (HP:0000847)	2.01716341
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.01211838
56	Absent speech (HP:0001344)	1.99035388
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95954596
58	Congenital stationary night blindness (HP:0007642)	1.94701047
59	Bile duct proliferation (HP:0001408)	1.94424161
60	Abnormal biliary tract physiology (HP:0012439)	1.94424161
61	Furrowed tongue (HP:0000221)	1.91503299
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91284693
63	Asplenia (HP:0001746)	1.89927555
64	Central scotoma (HP:0000603)	1.88386418
65	Sclerocornea (HP:0000647)	1.86467361
66	Abnormality of chloride homeostasis (HP:0011422)	1.84038498
67	Male infertility (HP:0003251)	1.83723712
68	Abnormality of the aortic arch (HP:0012303)	1.83107502
69	Cerebellar dysplasia (HP:0007033)	1.80585844
70	Tented upper lip vermilion (HP:0010804)	1.79336773
71	Polyuria (HP:0000103)	1.78411813
72	Fair hair (HP:0002286)	1.77150206
73	Clumsiness (HP:0002312)	1.76341355
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.74919516
75	Hyperaldosteronism (HP:0000859)	1.73566866
76	Tubulointerstitial abnormality (HP:0001969)	1.73442092
77	Type II lissencephaly (HP:0007260)	1.72288981
78	Abnormality of macular pigmentation (HP:0008002)	1.70750315
79	Congenital primary aphakia (HP:0007707)	1.69920616
80	Cone-rod dystrophy (HP:0000548)	1.66925820
81	Protruding tongue (HP:0010808)	1.63787752
82	Preaxial hand polydactyly (HP:0001177)	1.63622869
83	Stomach cancer (HP:0012126)	1.62724941
84	Gait imbalance (HP:0002141)	1.62697725
85	Enlarged kidneys (HP:0000105)	1.62501340
86	Poor coordination (HP:0002370)	1.60822081
87	Hypokalemic alkalosis (HP:0001949)	1.59960485
88	Abolished electroretinogram (ERG) (HP:0000550)	1.59709628
89	Widely spaced teeth (HP:0000687)	1.59254967
90	Oculomotor apraxia (HP:0000657)	1.58399756
91	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.57847547
92	Macular degeneration (HP:0000608)	1.53250536
93	Nephrogenic diabetes insipidus (HP:0009806)	1.51879617
94	Generalized hypopigmentation of hair (HP:0011358)	1.51524890
95	Abnormal urine output (HP:0012590)	1.51099415
96	Truncal obesity (HP:0001956)	1.50742287
97	Retinitis pigmentosa (HP:0000510)	1.50080549
98	Pancreatic islet-cell hyperplasia (HP:0004510)	1.48991335
99	Abnormality of renal excretion (HP:0011036)	1.48598960
100	Genital tract atresia (HP:0001827)	1.48151258

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.73945804
2	MAPK15	4.14324774
3	ADRBK2	3.41406172
4	ACVR1B	3.05072127
5	INSRR	2.51189859
6	BMPR1B	2.16119299
7	NLK	1.66023823
8	TAOK3	1.61359295
9	MAP3K7	1.52866911
10	TXK	1.51536893
11	MAP4K2	1.43342234
12	MELK	1.41179909
13	IRAK1	1.38614958
14	GRK1	1.36893811
15	MST4	1.35406201
16	PTK2B	1.31277196
17	LATS1	1.27593571
18	AKT3	1.27547227
19	STK38L	1.26987919
20	OXSR1	1.26842956
21	FGFR2	1.26116612
22	TNK2	1.25092578
23	TLK1	1.23643617
24	SIK2	1.22323973
25	NTRK3	1.19142518
26	WNK3	1.16067641
27	NUAK1	1.14691387
28	ADRBK1	1.10169345
29	MAPK13	1.08783917
30	TEC	1.08294202
31	STK39	1.04303439
32	CDK12	1.04297652
33	PNCK	1.01657300
34	MAPKAPK3	1.01317947
35	EEF2K	1.01039189
36	STK38	0.99192152
37	SGK2	0.97309630
38	FGFR3	0.96686500
39	MKNK2	0.95559218
40	WNK4	0.94878939
41	MAP2K6	0.93778487
42	PRKAA2	0.93128224
43	MAP4K1	0.87717623
44	ITK	0.86349969
45	PIK3CG	0.85474980
46	BRSK2	0.85123764
47	MAP3K2	0.85023645
48	PINK1	0.84238199
49	TRPM7	0.83953140
50	BLK	0.83572120
51	MAPK11	0.78315213
52	ERBB2	0.76967345
53	BTK	0.76809411
54	PIK3CA	0.75277558
55	MAP3K4	0.74236835
56	STK11	0.73246122
57	BRD4	0.71248312
58	CASK	0.68988996
59	ZAK	0.68155817
60	CAMK1G	0.67959741
61	GRK6	0.64915327
62	SGK1	0.64024240
63	NEK6	0.62884669
64	PRKCQ	0.62866232
65	CHUK	0.62155331
66	TNIK	0.61988307
67	IKBKE	0.60716432
68	MARK2	0.57781836
69	TGFBR1	0.54706046
70	PDK1	0.54514696
71	MARK3	0.54282740
72	STK3	0.53753657
73	PRKAA1	0.52097317
74	SGK223	0.51280478
75	SGK494	0.51280478
76	NEK2	0.50577304
77	EPHA3	0.50557186
78	WNK1	0.50408257
79	HIPK2	0.45972268
80	IKBKB	0.45307069
81	PRKCE	0.44618765
82	LCK	0.43273630
83	CSK	0.43206696
84	DYRK1A	0.43185162
85	SYK	0.43101678
86	NME1	0.42902457
87	CDC42BPA	0.39080171
88	ATR	0.38707656
89	PAK3	0.37277335
90	RPS6KB2	0.37266448
91	CAMK4	0.36952796
92	CAMKK2	0.36710033
93	PRKCH	0.34914248
94	CAMK1D	0.34865888
95	PRKCG	0.34844533
96	LYN	0.33505649
97	MAP2K2	0.32911428
98	ERN1	0.32903808
99	JAK1	0.32748361
100	HCK	0.31947094

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	3.00352744
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.75368057
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.65364880
4	Histidine metabolism_Homo sapiens_hsa00340	2.55368191
5	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.39108145
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.38902314
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.24166273
8	Butanoate metabolism_Homo sapiens_hsa00650	2.18324999
9	Caffeine metabolism_Homo sapiens_hsa00232	2.15320564
10	Retinol metabolism_Homo sapiens_hsa00830	2.07627990
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00873013
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88729741
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88309630
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.84116210
15	Phototransduction_Homo sapiens_hsa04744	1.74950414
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.69189594
17	Taste transduction_Homo sapiens_hsa04742	1.52927881
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.51892415
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.42757720
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.40518439
21	Sphingolipid metabolism_Homo sapiens_hsa00600	1.38229160
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.36149444
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.35630115
24	Fatty acid degradation_Homo sapiens_hsa00071	1.34691218
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34166883
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31982040
27	Lysine degradation_Homo sapiens_hsa00310	1.31958425
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.31949125
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31923081
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30532975
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28608910
32	Olfactory transduction_Homo sapiens_hsa04740	1.28029759
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.25184882
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22547611
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.20519711
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15541519
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09694799
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.07551373
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.06384246
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99711859
41	Circadian rhythm_Homo sapiens_hsa04710	0.98125023
42	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.94379639
43	Phenylalanine metabolism_Homo sapiens_hsa00360	0.93479719
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92518678
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92295549
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91902350
47	Nicotine addiction_Homo sapiens_hsa05033	0.85538562
48	Homologous recombination_Homo sapiens_hsa03440	0.82022993
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81397166
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.81114858
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80077830
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79261865
53	Peroxisome_Homo sapiens_hsa04146	0.78597137
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.77815968
55	Graft-versus-host disease_Homo sapiens_hsa05332	0.77657165
56	Serotonergic synapse_Homo sapiens_hsa04726	0.77563968
57	Morphine addiction_Homo sapiens_hsa05032	0.75890757
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74349910
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73684562
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.73654118
61	Salivary secretion_Homo sapiens_hsa04970	0.72180632
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68902556
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.68160111
64	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67747744
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.67517977
66	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65758398
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.65693081
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65475727
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.64557798
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62892745
71	Bile secretion_Homo sapiens_hsa04976	0.58179323
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.55930728
73	Insulin resistance_Homo sapiens_hsa04931	0.51622239
74	Allograft rejection_Homo sapiens_hsa05330	0.51033992
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50228649
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48481118
77	FoxO signaling pathway_Homo sapiens_hsa04068	0.47925374
78	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.47766312
79	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.44569953
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43109538
81	Propanoate metabolism_Homo sapiens_hsa00640	0.43106131
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.43101968
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43017055
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41442098
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.39163019
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.38925373
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37298653
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.36810471
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.36431460
90	Circadian entrainment_Homo sapiens_hsa04713	0.35424058
91	Insulin secretion_Homo sapiens_hsa04911	0.34379215
92	Regulation of autophagy_Homo sapiens_hsa04140	0.34305032
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.33696700
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33659326
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33134491
96	Asthma_Homo sapiens_hsa05310	0.32827109
97	Pancreatic secretion_Homo sapiens_hsa04972	0.32776870
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32064095
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31924036
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28848460

GOLGA2P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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