GOLGA2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.67783743
2chromosome condensation (GO:0030261)8.83281033
3plasma membrane fusion (GO:0045026)8.70930701
4DNA packaging (GO:0006323)8.65915478
5single strand break repair (GO:0000012)8.51192568
6spermatid nucleus differentiation (GO:0007289)8.12000002
7spermatid development (GO:0007286)7.81527427
8microtubule depolymerization (GO:0007019)7.56625363
9sperm-egg recognition (GO:0035036)7.21242439
10multicellular organism reproduction (GO:0032504)6.95204533
11sexual reproduction (GO:0019953)6.64681586
12reproduction (GO:0000003)6.62787053
13phosphatidylethanolamine biosynthetic process (GO:0006646)6.57607687
14microtubule polymerization or depolymerization (GO:0031109)6.57197990
15protein polyglutamylation (GO:0018095)6.54112265
16calcium ion-dependent exocytosis (GO:0017156)6.53577702
17centriole replication (GO:0007099)6.33418683
18protein targeting to Golgi (GO:0000042)6.32412988
19binding of sperm to zona pellucida (GO:0007339)6.29144829
20rRNA methylation (GO:0031167)6.19066128
21regulation of Rab GTPase activity (GO:0032313)6.14985478
22positive regulation of Rab GTPase activity (GO:0032851)6.14985478
23establishment of protein localization to Golgi (GO:0072600)6.11056967
24axonemal dynein complex assembly (GO:0070286)6.08649522
25phosphatidylethanolamine metabolic process (GO:0046337)6.07645703
26cell-cell recognition (GO:0009988)5.97074702
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.88884844
28spermatogenesis (GO:0007283)5.88072119
29male gamete generation (GO:0048232)5.86017842
30microtubule severing (GO:0051013)5.66843193
31regulation of transcription involved in cell fate commitment (GO:0060850)5.66119161
32negative regulation of inclusion body assembly (GO:0090084)5.63992663
33regulation of cilium movement (GO:0003352)5.47611259
34rRNA modification (GO:0000154)5.37122201
35gamete generation (GO:0007276)5.34149582
36centriole assembly (GO:0098534)5.31828950
37cellular ketone body metabolic process (GO:0046950)5.17721840
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06280451
39cell wall macromolecule metabolic process (GO:0044036)4.84651488
40cilium or flagellum-dependent cell motility (GO:0001539)4.82503469
41regulation of centriole replication (GO:0046599)4.74677502
42single fertilization (GO:0007338)4.65238109
43chromatin silencing (GO:0006342)4.58726929
44cell wall macromolecule catabolic process (GO:0016998)4.57927135
45ketone body metabolic process (GO:1902224)4.56358163
46protein localization to Golgi apparatus (GO:0034067)4.55828550
47RNA destabilization (GO:0050779)4.53802128
48germ cell development (GO:0007281)4.41728312
49motile cilium assembly (GO:0044458)4.40848815
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.33691677
51seminiferous tubule development (GO:0072520)4.27541928
52multicellular organismal reproductive process (GO:0048609)4.27430903
53coenzyme catabolic process (GO:0009109)4.09342867
54regulation of inclusion body assembly (GO:0090083)4.05133989
55Golgi to endosome transport (GO:0006895)4.03040193
56organic cation transport (GO:0015695)4.01964805
57epithelial cilium movement (GO:0003351)4.01336550
58fertilization (GO:0009566)3.90801895
59nucleus organization (GO:0006997)3.89837866
60multicellular organismal movement (GO:0050879)3.87755895
61musculoskeletal movement (GO:0050881)3.87755895
62regulation of microtubule-based movement (GO:0060632)3.79935388
63peptidyl-threonine dephosphorylation (GO:0035970)3.76312037
64cerebral cortex neuron differentiation (GO:0021895)3.74679813
65negative regulation of Rho protein signal transduction (GO:0035024)3.70909042
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.61145093
67response to acidic pH (GO:0010447)3.57527225
68cilium movement (GO:0003341)3.47944150
69glycerol ether metabolic process (GO:0006662)3.47089266
70regulation of interleukin-13 production (GO:0032656)3.41169090
71regulation of T-helper 2 cell differentiation (GO:0045628)3.37491684
72cellular response to pH (GO:0071467)3.21314378
73regulation of histone H3-K27 methylation (GO:0061085)3.20469794
74ether metabolic process (GO:0018904)3.19753056
75polyamine biosynthetic process (GO:0006596)3.17877971
76regulation of somitogenesis (GO:0014807)3.15949854
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15189439
78microtubule nucleation (GO:0007020)3.13580256
79negative regulation of gene expression, epigenetic (GO:0045814)3.12183796
80homeostasis of number of cells within a tissue (GO:0048873)3.07356876
81histone H3-K9 demethylation (GO:0033169)3.05366859
82multicellular organismal development (GO:0007275)2.99094268
83protein-DNA complex disassembly (GO:0032986)2.96694698
84nucleosome disassembly (GO:0006337)2.96694698
85membrane protein intracellular domain proteolysis (GO:0031293)2.96403299
86detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.92617545
87regulation of phosphoprotein phosphatase activity (GO:0043666)2.91299348
88NAD biosynthetic process (GO:0009435)2.90635447
89mitotic G1 DNA damage checkpoint (GO:0031571)2.90222674
90positive regulation of endothelial cell differentiation (GO:0045603)2.84576127
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.81954693
92mesenchymal cell differentiation involved in renal system development (GO:2001012)2.81954693
93cell recognition (GO:0008037)2.81843603
94regulation of guanylate cyclase activity (GO:0031282)2.80530141
95positive regulation of guanylate cyclase activity (GO:0031284)2.80144255
96cranial nerve morphogenesis (GO:0021602)2.79156653
97acrosome reaction (GO:0007340)11.7537259
98sperm motility (GO:0030317)11.5701236
99fusion of sperm to egg plasma membrane (GO:0007342)11.4360562
100response to pheromone (GO:0019236)10.2456121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.08440628
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.39038948
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77775258
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38248129
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.38248129
6CBP_20019798_ChIP-Seq_JUKART_Human2.25484031
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.25484031
8ELF1_20517297_ChIP-Seq_JURKAT_Human2.22559626
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.21969947
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17829275
11EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.11603020
12EZH2_22144423_ChIP-Seq_EOC_Human2.08636841
13RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.06216079
14ERA_21632823_ChIP-Seq_H3396_Human2.04099602
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03819221
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03324320
17NANOG_20526341_ChIP-Seq_ESCs_Human1.98029557
18DROSHA_22980978_ChIP-Seq_HELA_Human1.94377079
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.89227998
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.88328413
21BCL6_27268052_Chip-Seq_Bcells_Human1.88232613
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84483398
23RAC3_21632823_ChIP-Seq_H3396_Human1.82261766
24E2F1_20622854_ChIP-Seq_HELA_Human1.77468835
25CTCF_27219007_Chip-Seq_Bcells_Human1.74092626
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69982054
27TAF2_19829295_ChIP-Seq_ESCs_Human1.67143614
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66111289
29ER_23166858_ChIP-Seq_MCF-7_Human1.66039715
30SMC4_20622854_ChIP-Seq_HELA_Human1.65518721
31MYC_19829295_ChIP-Seq_ESCs_Human1.64515796
32BCOR_27268052_Chip-Seq_Bcells_Human1.64062852
33P68_20966046_ChIP-Seq_HELA_Human1.63745753
34PHF8_20622854_ChIP-Seq_HELA_Human1.63134354
35CTCF_20526341_ChIP-Seq_ESCs_Human1.61691299
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.60159711
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.60052348
38OCT4_20526341_ChIP-Seq_ESCs_Human1.58752045
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58184754
40FUS_26573619_Chip-Seq_HEK293_Human1.55239306
41P300_27268052_Chip-Seq_Bcells_Human1.54832853
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52370546
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.50497953
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.49673499
45AR_21572438_ChIP-Seq_LNCaP_Human1.47908656
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.47801343
47ERG_20517297_ChIP-Seq_VCAP_Human1.45486917
48TAF15_26573619_Chip-Seq_HEK293_Human1.44878778
49TP63_22573176_ChIP-Seq_HFKS_Human1.42530779
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.41173254
51AR_25329375_ChIP-Seq_VCAP_Human1.40006835
52ZNF274_21170338_ChIP-Seq_K562_Hela1.39750957
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37270164
54SMAD3_21741376_ChIP-Seq_ESCs_Human1.34358789
55P53_21459846_ChIP-Seq_SAOS-2_Human1.34326897
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.31792350
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31422998
58RBPJ_21746931_ChIP-Seq_IB4_Human1.30355579
59CEBPB_22108803_ChIP-Seq_LS180_Human1.30195996
60P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.29237144
61LXR_22292898_ChIP-Seq_THP-1_Human1.28658634
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.28438960
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28172537
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27906444
65ETV1_20927104_ChIP-Seq_GIST48_Human1.27852751
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26644512
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25520766
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24809572
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.23683438
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23560389
71SMRT_27268052_Chip-Seq_Bcells_Human1.22906649
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22250348
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22119840
74TP53_18474530_ChIP-ChIP_U2OS_Human1.19690874
75P300_19829295_ChIP-Seq_ESCs_Human1.17766572
76NFYB_21822215_ChIP-Seq_K562_Human1.16050830
77SA1_27219007_Chip-Seq_Bcells_Human1.14555432
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12787529
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10271204
80TBL1_22424771_ChIP-Seq_293T_Human1.10204171
81SOX2_19829295_ChIP-Seq_ESCs_Human1.09599999
82NANOG_19829295_ChIP-Seq_ESCs_Human1.09599999
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.09528888
84RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09524225
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09149522
86SPI1_20517297_ChIP-Seq_HL60_Human1.08736618
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08139483
88PHF8_20622853_ChIP-Seq_HELA_Human1.07620047
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06964212
90FOXH1_21741376_ChIP-Seq_ESCs_Human1.06341177
91RUNX_20019798_ChIP-Seq_JUKART_Human1.06265358
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.05162987
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.04227564
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.04180949
95STAT1_20625510_ChIP-Seq_HELA_Human1.03049481
96HOXB7_26014856_ChIP-Seq_BT474_Human1.02980207
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02478785
98RUNX2_22187159_ChIP-Seq_PCA_Human1.02287183
99OCT4_19829295_ChIP-Seq_ESCs_Human1.00579638
100NFYA_21822215_ChIP-Seq_K562_Human1.00526003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.27340074
2MP0003878_abnormal_ear_physiology5.27340074
3MP0005670_abnormal_white_adipose4.65601492
4MP0003698_abnormal_male_reproductive4.30351214
5MP0001348_abnormal_lacrimal_gland4.17691497
6MP0001929_abnormal_gametogenesis3.73321027
7MP0000678_abnormal_parathyroid_gland2.56997369
8MP0002822_catalepsy2.50841747
9MP0002161_abnormal_fertility/fecundity2.39832740
10MP0005379_endocrine/exocrine_gland_phen2.27683263
11MP0003718_maternal_effect2.16865219
12MP0005410_abnormal_fertilization12.0992781
13MP0002132_abnormal_respiratory_system1.98180500
14MP0002234_abnormal_pharynx_morphology1.70250242
15MP0003646_muscle_fatigue1.66988203
16MP0003011_delayed_dark_adaptation1.66661462
17MP0002210_abnormal_sex_determination1.64106425
18MP0001485_abnormal_pinna_reflex1.60636151
19MP0002249_abnormal_larynx_morphology1.56215167
20MP0005423_abnormal_somatic_nervous1.52022629
21MP0002282_abnormal_trachea_morphology1.50129289
22MP0001486_abnormal_startle_reflex1.46104864
23MP0009053_abnormal_anal_canal1.41990120
24MP0001145_abnormal_male_reproductive1.34103328
25MP0001968_abnormal_touch/_nociception1.33488288
26MP0002735_abnormal_chemical_nociception1.30889358
27MP0000653_abnormal_sex_gland1.30814825
28MP0004742_abnormal_vestibular_system1.30206935
29MP0004859_abnormal_synaptic_plasticity1.25763978
30MP0002138_abnormal_hepatobiliary_system1.23578707
31MP0005451_abnormal_body_composition1.15920072
32MP0005248_abnormal_Harderian_gland1.15134070
33MP0001765_abnormal_ion_homeostasis1.13387524
34MP0000534_abnormal_ureter_morphology1.13084009
35MP0002127_abnormal_cardiovascular_syste1.12786904
36MP0005310_abnormal_salivary_gland1.11564805
37MP0001963_abnormal_hearing_physiology1.10080527
38MP0004510_myositis1.00199383
39MP0000026_abnormal_inner_ear0.99405491
40MP0005395_other_phenotype0.97015555
41MP0001905_abnormal_dopamine_level0.96901600
42MP0008877_abnormal_DNA_methylation0.92993446
43MP0005551_abnormal_eye_electrophysiolog0.92655016
44MP0003879_abnormal_hair_cell0.90886431
45MP0002229_neurodegeneration0.87471847
46MP0005167_abnormal_blood-brain_barrier0.85889449
47MP0000681_abnormal_thyroid_gland0.84515086
48MP0008569_lethality_at_weaning0.81121588
49MP0000955_abnormal_spinal_cord0.76783154
50MP0002733_abnormal_thermal_nociception0.76707211
51MP0000049_abnormal_middle_ear0.74731841
52MP0002067_abnormal_sensory_capabilities0.74207828
53MP0000516_abnormal_urinary_system0.74040546
54MP0005367_renal/urinary_system_phenotyp0.74040546
55MP0005253_abnormal_eye_physiology0.71381288
56MP0002557_abnormal_social/conspecific_i0.71168321
57MP0004085_abnormal_heartbeat0.68172075
58MP0009745_abnormal_behavioral_response0.67569869
59MP0009115_abnormal_fat_cell0.66307004
60MP0004484_altered_response_of0.64278266
61MP0001440_abnormal_grooming_behavior0.61271320
62MP0005666_abnormal_adipose_tissue0.60721691
63MP0002572_abnormal_emotion/affect_behav0.60060155
64MP0001666_abnormal_nutrient_absorption0.59778293
65MP0005636_abnormal_mineral_homeostasis0.58923075
66MP0001879_abnormal_lymphatic_vessel0.58262037
67MP0005535_abnormal_body_temperature0.57719876
68MP0005375_adipose_tissue_phenotype0.55685370
69MP0002734_abnormal_mechanical_nocicepti0.52698237
70MP0003119_abnormal_digestive_system0.52419841
71MP0009764_decreased_sensitivity_to0.52361096
72MP0001970_abnormal_pain_threshold0.51839439
73MP0002272_abnormal_nervous_system0.50994283
74MP0008961_abnormal_basal_metabolism0.50553141
75MP0000003_abnormal_adipose_tissue0.50010930
76MP0003787_abnormal_imprinting0.48678163
77MP0000613_abnormal_salivary_gland0.46977520
78MP0001501_abnormal_sleep_pattern0.46736138
79MP0008995_early_reproductive_senescence0.46307712
80MP0000249_abnormal_blood_vessel0.46079332
81MP0001984_abnormal_olfaction0.45278814
82MP0000470_abnormal_stomach_morphology0.43281859
83MP0005083_abnormal_biliary_tract0.42830742
84MP0006292_abnormal_olfactory_placode0.42274014
85MP0003137_abnormal_impulse_conducting0.41039512
86MP0003699_abnormal_female_reproductive0.40002088
87MP0003077_abnormal_cell_cycle0.39877726
88MP0009697_abnormal_copulation0.39426129
89MP0000467_abnormal_esophagus_morphology0.39125024
90MP0004233_abnormal_muscle_weight0.36778106
91MP0002928_abnormal_bile_duct0.36148086
92MP0001270_distended_abdomen0.35971999
93MP0003936_abnormal_reproductive_system0.35971193
94MP0003635_abnormal_synaptic_transmissio0.35315586
95MP0005166_decreased_susceptibility_to0.32881842
96MP0002736_abnormal_nociception_after0.32420291
97MP0004036_abnormal_muscle_relaxation0.32250712
98MP0005391_vision/eye_phenotype0.31578288
99MP0000566_synostosis0.31491966
100MP0003880_abnormal_central_pattern0.30862998

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.03941162
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.76037214
3Absent/shortened dynein arms (HP:0200106)5.76037214
4Asymmetric septal hypertrophy (HP:0001670)5.73964113
5Attenuation of retinal blood vessels (HP:0007843)5.33042654
6Bell-shaped thorax (HP:0001591)5.30480514
7Bony spicule pigmentary retinopathy (HP:0007737)5.21422016
8Potter facies (HP:0002009)4.51934191
9Facial shape deformation (HP:0011334)4.51934191
10Hypoplastic ischia (HP:0003175)4.48314742
11Abnormal ciliary motility (HP:0012262)4.35362008
12Resting tremor (HP:0002322)4.26630823
13Abnormal respiratory motile cilium morphology (HP:0005938)4.22574986
14Abnormal respiratory epithelium morphology (HP:0012253)4.22574986
15Abnormal respiratory motile cilium physiology (HP:0012261)4.20527660
16Tubulointerstitial nephritis (HP:0001970)4.16296378
17Male infertility (HP:0003251)4.12645300
18Hyperkalemia (HP:0002153)4.09218240
19Abnormal rod and cone electroretinograms (HP:0008323)4.08454527
20Infertility (HP:0000789)4.06514991
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.99780434
22Abnormality of the ischium (HP:0003174)3.96013206
23Enlarged epiphyses (HP:0010580)3.90062712
24Chronic hepatic failure (HP:0100626)3.79211884
25Impulsivity (HP:0100710)3.78748772
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.64479994
27Abnormality of macular pigmentation (HP:0008002)3.63176605
28Nasal polyposis (HP:0100582)3.58498932
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.53242536
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45294315
31Abnormal spermatogenesis (HP:0008669)3.36072778
32Nephronophthisis (HP:0000090)3.34271196
33Hypoplasia of the thymus (HP:0000778)3.24341440
34Azoospermia (HP:0000027)3.18634087
35Cone-rod dystrophy (HP:0000548)3.17750265
36Abnormal urine output (HP:0012590)3.11225986
37Postural instability (HP:0002172)2.95622988
38Abnormality of the nasal mucosa (HP:0000433)2.90395555
39Epiphyseal dysplasia (HP:0002656)2.89511377
40Abnormality of the renal medulla (HP:0100957)2.88413163
41Renal dysplasia (HP:0000110)2.71718235
42Abnormal drinking behavior (HP:0030082)2.66401478
43Polydipsia (HP:0001959)2.66401478
44Abnormality of renal excretion (HP:0011036)2.64778060
45Double outlet right ventricle (HP:0001719)2.64546377
46Congenital malformation of the right heart (HP:0011723)2.64546377
47Unilateral renal agenesis (HP:0000122)2.61752593
48Abnormality of the costochondral junction (HP:0000919)2.61688917
49Progressive cerebellar ataxia (HP:0002073)2.60574411
50Portal hypertension (HP:0001409)2.58836578
51Amelogenesis imperfecta (HP:0000705)2.57639526
52Type II lissencephaly (HP:0007260)2.57439286
53Generalized aminoaciduria (HP:0002909)2.55399998
54Widely patent fontanelles and sutures (HP:0004492)2.51714592
55Polyuria (HP:0000103)2.51460951
56Abnormality of potassium homeostasis (HP:0011042)2.49343539
57Rhinitis (HP:0012384)2.47011205
58Stage 5 chronic kidney disease (HP:0003774)2.46167156
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.43762120
60Absent epiphyses (HP:0010577)2.43762120
61Tubulointerstitial abnormality (HP:0001969)2.38912089
62Abnormality of the hepatic vasculature (HP:0006707)2.36105955
63Abnormality of dental color (HP:0011073)2.35547698
64Abnormality of the aortic arch (HP:0012303)2.26794753
65Spastic paraparesis (HP:0002313)2.24329267
66Hypophosphatemic rickets (HP:0004912)2.21981827
67Progressive sensorineural hearing impairment (HP:0000408)2.18753743
68Abnormality of the pubic bones (HP:0003172)2.17533171
69Truncal obesity (HP:0001956)2.16635158
70Hypoalphalipoproteinemia (HP:0003233)2.14918472
71Abnormal ventriculo-arterial connection (HP:0011563)2.13349430
72Transposition of the great arteries (HP:0001669)2.13349430
73Abnormal connection of the cardiac segments (HP:0011545)2.13349430
74Insulin-resistant diabetes mellitus (HP:0000831)2.12070954
75Retinal dysplasia (HP:0007973)2.10754066
76Abnormality of the epiphysis of the femoral head (HP:0010574)2.06420960
77Ventricular tachycardia (HP:0004756)2.02298453
78Abnormality of the parathyroid morphology (HP:0011766)2.01917416
79Flattened epiphyses (HP:0003071)2.00966675
80Menstrual irregularities (HP:0000858)1.99839310
81Renal Fanconi syndrome (HP:0001994)1.99141612
82Recurrent corneal erosions (HP:0000495)1.98396175
83Hyponatremia (HP:0002902)1.96909470
84Intellectual disability, moderate (HP:0002342)1.95276193
85Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93839715
86Abnormality of femoral epiphyses (HP:0006499)1.93839715
87Occipital encephalocele (HP:0002085)1.93354703
88Decreased central vision (HP:0007663)1.90491671
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89678709
90Tubular atrophy (HP:0000092)1.88276474
91Bronchiectasis (HP:0002110)1.88201475
92Short ribs (HP:0000773)1.85949469
93Recurrent pneumonia (HP:0006532)1.85322076
94Anterior segment dysgenesis (HP:0007700)1.84863627
95Cerebellar dysplasia (HP:0007033)1.84403996
96Tetany (HP:0001281)1.84397285
97Abnormality of the femoral head (HP:0003368)1.83364750
98Flat capital femoral epiphysis (HP:0003370)1.81444944
99Protuberant abdomen (HP:0001538)1.81071934
100Photophobia (HP:0000613)1.77332246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.91542587
2TESK16.48460414
3DDR25.56512395
4PLK23.39492809
5INSRR3.20132758
6STK383.10449867
7MAP4K22.57455939
8MAPK152.52441819
9PNCK2.35646223
10BRD42.31990992
11STK38L2.17597544
12CAMK1G1.96650896
13MST1R1.82603992
14PRKD31.70847386
15PDPK11.57447604
16PDK11.45938780
17PIK3CG1.43909883
18WNK11.43679671
19CDK191.39884015
20CDK71.36086667
21DYRK1B1.20053290
22PTK2B1.19445456
23KSR21.10289358
24NEK60.98199303
25CDK120.95494587
26TESK20.84665031
27AKT30.83053761
28SIK20.81472301
29MAP3K90.79571498
30MAP3K20.76414957
31UHMK10.75729847
32PRKG10.75497932
33RPS6KA20.75473357
34WNK40.73409744
35TAOK30.73086533
36CAMK1D0.72138550
37MAP3K110.69817744
38PRKG20.68573216
39RIPK40.66906060
40RPS6KA10.66435328
41BRAF0.64717929
42PRKAA20.62549191
43MAP2K20.61104535
44JAK30.56518709
45MUSK0.55602928
46LATS20.55583019
47BMPR1B0.51381561
48MAP3K130.50244686
49STK390.49657263
50ADRBK20.48212225
51ROCK10.47128148
52OXSR10.46741207
53LATS10.46549574
54MET0.45700510
55CDK30.45595305
56MAP3K80.45503151
57CDK20.43584253
58RPS6KL10.41724334
59RPS6KC10.41724334
60CAMK10.41423893
61RPS6KA60.41125238
62ARAF0.41077450
63MAPK10.40062663
64GSK3B0.40037411
65CDK10.36012862
66MAPK110.33354847
67NTRK30.33049714
68TYRO30.32700148
69PRKCG0.32435439
70FRK0.32165158
71PRKCZ0.31978463
72MAPK80.31701700
73CDK40.30317411
74SGK2230.30179310
75SGK4940.30179310
76MAP3K10.29843030
77PRKCB0.29349347
78SGK10.27808908
79MAP3K40.26910524
80CHEK10.25942949
81IKBKB0.25565830
82MTOR0.24427621
83FER0.23618536
84MARK10.22487916
85CHUK0.21307739
86MAPK140.20514099
87ZAK0.19399376
88CAMK40.18024892
89TIE10.16216045
90MAPK100.15058581
91KIT0.15047445
92BRSK10.14296566
93PKN10.14032835
94PRKCE0.12885780
95MAP3K70.11659879
96AKT10.10680526
97PRKACB0.10171363
98NUAK10.09782514
99TXK0.09662328
100PRKCQ0.09148143

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.31974398
2Fatty acid biosynthesis_Homo sapiens_hsa000615.81722807
3Olfactory transduction_Homo sapiens_hsa047404.10007093
4Butanoate metabolism_Homo sapiens_hsa006502.39740157
5Allograft rejection_Homo sapiens_hsa053302.24986529
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18469681
7Autoimmune thyroid disease_Homo sapiens_hsa053202.18275891
8Type I diabetes mellitus_Homo sapiens_hsa049402.16585323
9Graft-versus-host disease_Homo sapiens_hsa053322.09269733
10Glycerophospholipid metabolism_Homo sapiens_hsa005642.06856404
11Dorso-ventral axis formation_Homo sapiens_hsa043201.79923745
12Taste transduction_Homo sapiens_hsa047421.73729995
13Antigen processing and presentation_Homo sapiens_hsa046121.67236931
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60636947
15Type II diabetes mellitus_Homo sapiens_hsa049301.48158476
16Phototransduction_Homo sapiens_hsa047441.46990718
17Fatty acid degradation_Homo sapiens_hsa000711.46789963
18Viral myocarditis_Homo sapiens_hsa054161.46263112
19Phenylalanine metabolism_Homo sapiens_hsa003601.45045305
20Selenocompound metabolism_Homo sapiens_hsa004501.36604757
21RNA transport_Homo sapiens_hsa030131.33458880
22Fatty acid metabolism_Homo sapiens_hsa012121.30162708
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26087853
24Protein digestion and absorption_Homo sapiens_hsa049741.24050673
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.22388496
26Synaptic vesicle cycle_Homo sapiens_hsa047211.22330809
27Arginine and proline metabolism_Homo sapiens_hsa003301.15623644
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09133388
29Endocytosis_Homo sapiens_hsa041441.01085126
30Salivary secretion_Homo sapiens_hsa049701.01050226
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96769110
32ABC transporters_Homo sapiens_hsa020100.94994663
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93187579
34Oocyte meiosis_Homo sapiens_hsa041140.91503276
35Renin-angiotensin system_Homo sapiens_hsa046140.88618621
36Calcium signaling pathway_Homo sapiens_hsa040200.88096483
37Morphine addiction_Homo sapiens_hsa050320.88074395
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83797890
39Inositol phosphate metabolism_Homo sapiens_hsa005620.83753868
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83347457
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82790012
42Cardiac muscle contraction_Homo sapiens_hsa042600.81295882
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.80944854
44Circadian entrainment_Homo sapiens_hsa047130.78840357
45PPAR signaling pathway_Homo sapiens_hsa033200.77729538
46Fat digestion and absorption_Homo sapiens_hsa049750.76772446
47Nicotine addiction_Homo sapiens_hsa050330.76086545
48cAMP signaling pathway_Homo sapiens_hsa040240.76040672
49Arginine biosynthesis_Homo sapiens_hsa002200.75233835
50Tyrosine metabolism_Homo sapiens_hsa003500.75149392
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70985855
52Influenza A_Homo sapiens_hsa051640.70644342
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67962624
54Hedgehog signaling pathway_Homo sapiens_hsa043400.66022305
55Glycerolipid metabolism_Homo sapiens_hsa005610.65890553
56Gastric acid secretion_Homo sapiens_hsa049710.65710106
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64872015
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63883792
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57658720
60Retinol metabolism_Homo sapiens_hsa008300.57650521
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57057674
62Basal transcription factors_Homo sapiens_hsa030220.55932991
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.55392463
64Bile secretion_Homo sapiens_hsa049760.52932819
65Purine metabolism_Homo sapiens_hsa002300.52196351
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50899855
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.49760038
68Estrogen signaling pathway_Homo sapiens_hsa049150.45962207
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45662140
70Renin secretion_Homo sapiens_hsa049240.44875890
71Acute myeloid leukemia_Homo sapiens_hsa052210.44366865
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43533277
73Glutamatergic synapse_Homo sapiens_hsa047240.40870602
74Cholinergic synapse_Homo sapiens_hsa047250.40471174
75Herpes simplex infection_Homo sapiens_hsa051680.40454786
76Insulin secretion_Homo sapiens_hsa049110.39477450
77MAPK signaling pathway_Homo sapiens_hsa040100.38713718
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.38296257
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.33647919
80GABAergic synapse_Homo sapiens_hsa047270.32828956
81Tight junction_Homo sapiens_hsa045300.30961244
82Serotonergic synapse_Homo sapiens_hsa047260.29708051
83Fanconi anemia pathway_Homo sapiens_hsa034600.28701130
84Viral carcinogenesis_Homo sapiens_hsa052030.27531462
85Linoleic acid metabolism_Homo sapiens_hsa005910.27353198
86Biosynthesis of amino acids_Homo sapiens_hsa012300.27029800
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26574034
88Oxytocin signaling pathway_Homo sapiens_hsa049210.26558214
89Nitrogen metabolism_Homo sapiens_hsa009100.25367560
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24302766
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23898662
92Pancreatic secretion_Homo sapiens_hsa049720.22677848
93VEGF signaling pathway_Homo sapiens_hsa043700.22256305
94Prolactin signaling pathway_Homo sapiens_hsa049170.21945342
95Huntingtons disease_Homo sapiens_hsa050160.21736988
96mRNA surveillance pathway_Homo sapiens_hsa030150.21232078
97Tryptophan metabolism_Homo sapiens_hsa003800.19732909
98B cell receptor signaling pathway_Homo sapiens_hsa046620.19699299
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.19515655
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19051343

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