ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.67783743
2	chromosome condensation (GO:0030261)	8.83281033
3	plasma membrane fusion (GO:0045026)	8.70930701
4	DNA packaging (GO:0006323)	8.65915478
5	single strand break repair (GO:0000012)	8.51192568
6	spermatid nucleus differentiation (GO:0007289)	8.12000002
7	spermatid development (GO:0007286)	7.81527427
8	microtubule depolymerization (GO:0007019)	7.56625363
9	sperm-egg recognition (GO:0035036)	7.21242439
10	multicellular organism reproduction (GO:0032504)	6.95204533
11	sexual reproduction (GO:0019953)	6.64681586
12	reproduction (GO:0000003)	6.62787053
13	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.57607687
14	microtubule polymerization or depolymerization (GO:0031109)	6.57197990
15	protein polyglutamylation (GO:0018095)	6.54112265
16	calcium ion-dependent exocytosis (GO:0017156)	6.53577702
17	centriole replication (GO:0007099)	6.33418683
18	protein targeting to Golgi (GO:0000042)	6.32412988
19	binding of sperm to zona pellucida (GO:0007339)	6.29144829
20	rRNA methylation (GO:0031167)	6.19066128
21	regulation of Rab GTPase activity (GO:0032313)	6.14985478
22	positive regulation of Rab GTPase activity (GO:0032851)	6.14985478
23	establishment of protein localization to Golgi (GO:0072600)	6.11056967
24	axonemal dynein complex assembly (GO:0070286)	6.08649522
25	phosphatidylethanolamine metabolic process (GO:0046337)	6.07645703
26	cell-cell recognition (GO:0009988)	5.97074702
27	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.88884844
28	spermatogenesis (GO:0007283)	5.88072119
29	male gamete generation (GO:0048232)	5.86017842
30	microtubule severing (GO:0051013)	5.66843193
31	regulation of transcription involved in cell fate commitment (GO:0060850)	5.66119161
32	negative regulation of inclusion body assembly (GO:0090084)	5.63992663
33	regulation of cilium movement (GO:0003352)	5.47611259
34	rRNA modification (GO:0000154)	5.37122201
35	gamete generation (GO:0007276)	5.34149582
36	centriole assembly (GO:0098534)	5.31828950
37	cellular ketone body metabolic process (GO:0046950)	5.17721840
38	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.06280451
39	cell wall macromolecule metabolic process (GO:0044036)	4.84651488
40	cilium or flagellum-dependent cell motility (GO:0001539)	4.82503469
41	regulation of centriole replication (GO:0046599)	4.74677502
42	single fertilization (GO:0007338)	4.65238109
43	chromatin silencing (GO:0006342)	4.58726929
44	cell wall macromolecule catabolic process (GO:0016998)	4.57927135
45	ketone body metabolic process (GO:1902224)	4.56358163
46	protein localization to Golgi apparatus (GO:0034067)	4.55828550
47	RNA destabilization (GO:0050779)	4.53802128
48	germ cell development (GO:0007281)	4.41728312
49	motile cilium assembly (GO:0044458)	4.40848815
50	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.33691677
51	seminiferous tubule development (GO:0072520)	4.27541928
52	multicellular organismal reproductive process (GO:0048609)	4.27430903
53	coenzyme catabolic process (GO:0009109)	4.09342867
54	regulation of inclusion body assembly (GO:0090083)	4.05133989
55	Golgi to endosome transport (GO:0006895)	4.03040193
56	organic cation transport (GO:0015695)	4.01964805
57	epithelial cilium movement (GO:0003351)	4.01336550
58	fertilization (GO:0009566)	3.90801895
59	nucleus organization (GO:0006997)	3.89837866
60	multicellular organismal movement (GO:0050879)	3.87755895
61	musculoskeletal movement (GO:0050881)	3.87755895
62	regulation of microtubule-based movement (GO:0060632)	3.79935388
63	peptidyl-threonine dephosphorylation (GO:0035970)	3.76312037
64	cerebral cortex neuron differentiation (GO:0021895)	3.74679813
65	negative regulation of Rho protein signal transduction (GO:0035024)	3.70909042
66	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.61145093
67	response to acidic pH (GO:0010447)	3.57527225
68	cilium movement (GO:0003341)	3.47944150
69	glycerol ether metabolic process (GO:0006662)	3.47089266
70	regulation of interleukin-13 production (GO:0032656)	3.41169090
71	regulation of T-helper 2 cell differentiation (GO:0045628)	3.37491684
72	cellular response to pH (GO:0071467)	3.21314378
73	regulation of histone H3-K27 methylation (GO:0061085)	3.20469794
74	ether metabolic process (GO:0018904)	3.19753056
75	polyamine biosynthetic process (GO:0006596)	3.17877971
76	regulation of somitogenesis (GO:0014807)	3.15949854
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.15189439
78	microtubule nucleation (GO:0007020)	3.13580256
79	negative regulation of gene expression, epigenetic (GO:0045814)	3.12183796
80	homeostasis of number of cells within a tissue (GO:0048873)	3.07356876
81	histone H3-K9 demethylation (GO:0033169)	3.05366859
82	multicellular organismal development (GO:0007275)	2.99094268
83	protein-DNA complex disassembly (GO:0032986)	2.96694698
84	nucleosome disassembly (GO:0006337)	2.96694698
85	membrane protein intracellular domain proteolysis (GO:0031293)	2.96403299
86	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.92617545
87	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.91299348
88	NAD biosynthetic process (GO:0009435)	2.90635447
89	mitotic G1 DNA damage checkpoint (GO:0031571)	2.90222674
90	positive regulation of endothelial cell differentiation (GO:0045603)	2.84576127
91	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.81954693
92	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.81954693
93	cell recognition (GO:0008037)	2.81843603
94	regulation of guanylate cyclase activity (GO:0031282)	2.80530141
95	positive regulation of guanylate cyclase activity (GO:0031284)	2.80144255
96	cranial nerve morphogenesis (GO:0021602)	2.79156653
97	acrosome reaction (GO:0007340)	11.7537259
98	sperm motility (GO:0030317)	11.5701236
99	fusion of sperm to egg plasma membrane (GO:0007342)	11.4360562
100	response to pheromone (GO:0019236)	10.2456121

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.08440628
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.39038948
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.77775258
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38248129
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.38248129
6	CBP_20019798_ChIP-Seq_JUKART_Human	2.25484031
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.25484031
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.22559626
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.21969947
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17829275
11	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.11603020
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.08636841
13	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.06216079
14	ERA_21632823_ChIP-Seq_H3396_Human	2.04099602
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03819221
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03324320
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.98029557
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.94377079
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.89227998
20	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.88328413
21	BCL6_27268052_Chip-Seq_Bcells_Human	1.88232613
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84483398
23	RAC3_21632823_ChIP-Seq_H3396_Human	1.82261766
24	E2F1_20622854_ChIP-Seq_HELA_Human	1.77468835
25	CTCF_27219007_Chip-Seq_Bcells_Human	1.74092626
26	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.69982054
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.67143614
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66111289
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.66039715
30	SMC4_20622854_ChIP-Seq_HELA_Human	1.65518721
31	MYC_19829295_ChIP-Seq_ESCs_Human	1.64515796
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.64062852
33	P68_20966046_ChIP-Seq_HELA_Human	1.63745753
34	PHF8_20622854_ChIP-Seq_HELA_Human	1.63134354
35	CTCF_20526341_ChIP-Seq_ESCs_Human	1.61691299
36	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.60159711
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.60052348
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.58752045
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.58184754
40	FUS_26573619_Chip-Seq_HEK293_Human	1.55239306
41	P300_27268052_Chip-Seq_Bcells_Human	1.54832853
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52370546
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.50497953
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.49673499
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.47908656
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.47801343
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.45486917
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.44878778
49	TP63_22573176_ChIP-Seq_HFKS_Human	1.42530779
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41173254
51	AR_25329375_ChIP-Seq_VCAP_Human	1.40006835
52	ZNF274_21170338_ChIP-Seq_K562_Hela	1.39750957
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37270164
54	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.34358789
55	P53_21459846_ChIP-Seq_SAOS-2_Human	1.34326897
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31792350
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.31422998
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30355579
59	CEBPB_22108803_ChIP-Seq_LS180_Human	1.30195996
60	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.29237144
61	LXR_22292898_ChIP-Seq_THP-1_Human	1.28658634
62	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.28438960
63	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.28172537
64	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.27906444
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.27852751
66	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.26644512
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25520766
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24809572
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23683438
70	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.23560389
71	SMRT_27268052_Chip-Seq_Bcells_Human	1.22906649
72	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.22250348
73	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22119840
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.19690874
75	P300_19829295_ChIP-Seq_ESCs_Human	1.17766572
76	NFYB_21822215_ChIP-Seq_K562_Human	1.16050830
77	SA1_27219007_Chip-Seq_Bcells_Human	1.14555432
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12787529
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10271204
80	TBL1_22424771_ChIP-Seq_293T_Human	1.10204171
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09599999
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09599999
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09528888
84	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.09524225
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.09149522
86	SPI1_20517297_ChIP-Seq_HL60_Human	1.08736618
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08139483
88	PHF8_20622853_ChIP-Seq_HELA_Human	1.07620047
89	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06964212
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06341177
91	RUNX_20019798_ChIP-Seq_JUKART_Human	1.06265358
92	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.05162987
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04227564
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04180949
95	STAT1_20625510_ChIP-Seq_HELA_Human	1.03049481
96	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02980207
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02478785
98	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02287183
99	OCT4_19829295_ChIP-Seq_ESCs_Human	1.00579638
100	NFYA_21822215_ChIP-Seq_K562_Human	1.00526003

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.27340074
2	MP0003878_abnormal_ear_physiology	5.27340074
3	MP0005670_abnormal_white_adipose	4.65601492
4	MP0003698_abnormal_male_reproductive	4.30351214
5	MP0001348_abnormal_lacrimal_gland	4.17691497
6	MP0001929_abnormal_gametogenesis	3.73321027
7	MP0000678_abnormal_parathyroid_gland	2.56997369
8	MP0002822_catalepsy	2.50841747
9	MP0002161_abnormal_fertility/fecundity	2.39832740
10	MP0005379_endocrine/exocrine_gland_phen	2.27683263
11	MP0003718_maternal_effect	2.16865219
12	MP0005410_abnormal_fertilization	12.0992781
13	MP0002132_abnormal_respiratory_system	1.98180500
14	MP0002234_abnormal_pharynx_morphology	1.70250242
15	MP0003646_muscle_fatigue	1.66988203
16	MP0003011_delayed_dark_adaptation	1.66661462
17	MP0002210_abnormal_sex_determination	1.64106425
18	MP0001485_abnormal_pinna_reflex	1.60636151
19	MP0002249_abnormal_larynx_morphology	1.56215167
20	MP0005423_abnormal_somatic_nervous	1.52022629
21	MP0002282_abnormal_trachea_morphology	1.50129289
22	MP0001486_abnormal_startle_reflex	1.46104864
23	MP0009053_abnormal_anal_canal	1.41990120
24	MP0001145_abnormal_male_reproductive	1.34103328
25	MP0001968_abnormal_touch/_nociception	1.33488288
26	MP0002735_abnormal_chemical_nociception	1.30889358
27	MP0000653_abnormal_sex_gland	1.30814825
28	MP0004742_abnormal_vestibular_system	1.30206935
29	MP0004859_abnormal_synaptic_plasticity	1.25763978
30	MP0002138_abnormal_hepatobiliary_system	1.23578707
31	MP0005451_abnormal_body_composition	1.15920072
32	MP0005248_abnormal_Harderian_gland	1.15134070
33	MP0001765_abnormal_ion_homeostasis	1.13387524
34	MP0000534_abnormal_ureter_morphology	1.13084009
35	MP0002127_abnormal_cardiovascular_syste	1.12786904
36	MP0005310_abnormal_salivary_gland	1.11564805
37	MP0001963_abnormal_hearing_physiology	1.10080527
38	MP0004510_myositis	1.00199383
39	MP0000026_abnormal_inner_ear	0.99405491
40	MP0005395_other_phenotype	0.97015555
41	MP0001905_abnormal_dopamine_level	0.96901600
42	MP0008877_abnormal_DNA_methylation	0.92993446
43	MP0005551_abnormal_eye_electrophysiolog	0.92655016
44	MP0003879_abnormal_hair_cell	0.90886431
45	MP0002229_neurodegeneration	0.87471847
46	MP0005167_abnormal_blood-brain_barrier	0.85889449
47	MP0000681_abnormal_thyroid_gland	0.84515086
48	MP0008569_lethality_at_weaning	0.81121588
49	MP0000955_abnormal_spinal_cord	0.76783154
50	MP0002733_abnormal_thermal_nociception	0.76707211
51	MP0000049_abnormal_middle_ear	0.74731841
52	MP0002067_abnormal_sensory_capabilities	0.74207828
53	MP0000516_abnormal_urinary_system	0.74040546
54	MP0005367_renal/urinary_system_phenotyp	0.74040546
55	MP0005253_abnormal_eye_physiology	0.71381288
56	MP0002557_abnormal_social/conspecific_i	0.71168321
57	MP0004085_abnormal_heartbeat	0.68172075
58	MP0009745_abnormal_behavioral_response	0.67569869
59	MP0009115_abnormal_fat_cell	0.66307004
60	MP0004484_altered_response_of	0.64278266
61	MP0001440_abnormal_grooming_behavior	0.61271320
62	MP0005666_abnormal_adipose_tissue	0.60721691
63	MP0002572_abnormal_emotion/affect_behav	0.60060155
64	MP0001666_abnormal_nutrient_absorption	0.59778293
65	MP0005636_abnormal_mineral_homeostasis	0.58923075
66	MP0001879_abnormal_lymphatic_vessel	0.58262037
67	MP0005535_abnormal_body_temperature	0.57719876
68	MP0005375_adipose_tissue_phenotype	0.55685370
69	MP0002734_abnormal_mechanical_nocicepti	0.52698237
70	MP0003119_abnormal_digestive_system	0.52419841
71	MP0009764_decreased_sensitivity_to	0.52361096
72	MP0001970_abnormal_pain_threshold	0.51839439
73	MP0002272_abnormal_nervous_system	0.50994283
74	MP0008961_abnormal_basal_metabolism	0.50553141
75	MP0000003_abnormal_adipose_tissue	0.50010930
76	MP0003787_abnormal_imprinting	0.48678163
77	MP0000613_abnormal_salivary_gland	0.46977520
78	MP0001501_abnormal_sleep_pattern	0.46736138
79	MP0008995_early_reproductive_senescence	0.46307712
80	MP0000249_abnormal_blood_vessel	0.46079332
81	MP0001984_abnormal_olfaction	0.45278814
82	MP0000470_abnormal_stomach_morphology	0.43281859
83	MP0005083_abnormal_biliary_tract	0.42830742
84	MP0006292_abnormal_olfactory_placode	0.42274014
85	MP0003137_abnormal_impulse_conducting	0.41039512
86	MP0003699_abnormal_female_reproductive	0.40002088
87	MP0003077_abnormal_cell_cycle	0.39877726
88	MP0009697_abnormal_copulation	0.39426129
89	MP0000467_abnormal_esophagus_morphology	0.39125024
90	MP0004233_abnormal_muscle_weight	0.36778106
91	MP0002928_abnormal_bile_duct	0.36148086
92	MP0001270_distended_abdomen	0.35971999
93	MP0003936_abnormal_reproductive_system	0.35971193
94	MP0003635_abnormal_synaptic_transmissio	0.35315586
95	MP0005166_decreased_susceptibility_to	0.32881842
96	MP0002736_abnormal_nociception_after	0.32420291
97	MP0004036_abnormal_muscle_relaxation	0.32250712
98	MP0005391_vision/eye_phenotype	0.31578288
99	MP0000566_synostosis	0.31491966
100	MP0003880_abnormal_central_pattern	0.30862998

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.03941162
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.76037214
3	Absent/shortened dynein arms (HP:0200106)	5.76037214
4	Asymmetric septal hypertrophy (HP:0001670)	5.73964113
5	Attenuation of retinal blood vessels (HP:0007843)	5.33042654
6	Bell-shaped thorax (HP:0001591)	5.30480514
7	Bony spicule pigmentary retinopathy (HP:0007737)	5.21422016
8	Potter facies (HP:0002009)	4.51934191
9	Facial shape deformation (HP:0011334)	4.51934191
10	Hypoplastic ischia (HP:0003175)	4.48314742
11	Abnormal ciliary motility (HP:0012262)	4.35362008
12	Resting tremor (HP:0002322)	4.26630823
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.22574986
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.22574986
15	Abnormal respiratory motile cilium physiology (HP:0012261)	4.20527660
16	Tubulointerstitial nephritis (HP:0001970)	4.16296378
17	Male infertility (HP:0003251)	4.12645300
18	Hyperkalemia (HP:0002153)	4.09218240
19	Abnormal rod and cone electroretinograms (HP:0008323)	4.08454527
20	Infertility (HP:0000789)	4.06514991
21	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.99780434
22	Abnormality of the ischium (HP:0003174)	3.96013206
23	Enlarged epiphyses (HP:0010580)	3.90062712
24	Chronic hepatic failure (HP:0100626)	3.79211884
25	Impulsivity (HP:0100710)	3.78748772
26	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.64479994
27	Abnormality of macular pigmentation (HP:0008002)	3.63176605
28	Nasal polyposis (HP:0100582)	3.58498932
29	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.53242536
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.45294315
31	Abnormal spermatogenesis (HP:0008669)	3.36072778
32	Nephronophthisis (HP:0000090)	3.34271196
33	Hypoplasia of the thymus (HP:0000778)	3.24341440
34	Azoospermia (HP:0000027)	3.18634087
35	Cone-rod dystrophy (HP:0000548)	3.17750265
36	Abnormal urine output (HP:0012590)	3.11225986
37	Postural instability (HP:0002172)	2.95622988
38	Abnormality of the nasal mucosa (HP:0000433)	2.90395555
39	Epiphyseal dysplasia (HP:0002656)	2.89511377
40	Abnormality of the renal medulla (HP:0100957)	2.88413163
41	Renal dysplasia (HP:0000110)	2.71718235
42	Abnormal drinking behavior (HP:0030082)	2.66401478
43	Polydipsia (HP:0001959)	2.66401478
44	Abnormality of renal excretion (HP:0011036)	2.64778060
45	Double outlet right ventricle (HP:0001719)	2.64546377
46	Congenital malformation of the right heart (HP:0011723)	2.64546377
47	Unilateral renal agenesis (HP:0000122)	2.61752593
48	Abnormality of the costochondral junction (HP:0000919)	2.61688917
49	Progressive cerebellar ataxia (HP:0002073)	2.60574411
50	Portal hypertension (HP:0001409)	2.58836578
51	Amelogenesis imperfecta (HP:0000705)	2.57639526
52	Type II lissencephaly (HP:0007260)	2.57439286
53	Generalized aminoaciduria (HP:0002909)	2.55399998
54	Widely patent fontanelles and sutures (HP:0004492)	2.51714592
55	Polyuria (HP:0000103)	2.51460951
56	Abnormality of potassium homeostasis (HP:0011042)	2.49343539
57	Rhinitis (HP:0012384)	2.47011205
58	Stage 5 chronic kidney disease (HP:0003774)	2.46167156
59	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.43762120
60	Absent epiphyses (HP:0010577)	2.43762120
61	Tubulointerstitial abnormality (HP:0001969)	2.38912089
62	Abnormality of the hepatic vasculature (HP:0006707)	2.36105955
63	Abnormality of dental color (HP:0011073)	2.35547698
64	Abnormality of the aortic arch (HP:0012303)	2.26794753
65	Spastic paraparesis (HP:0002313)	2.24329267
66	Hypophosphatemic rickets (HP:0004912)	2.21981827
67	Progressive sensorineural hearing impairment (HP:0000408)	2.18753743
68	Abnormality of the pubic bones (HP:0003172)	2.17533171
69	Truncal obesity (HP:0001956)	2.16635158
70	Hypoalphalipoproteinemia (HP:0003233)	2.14918472
71	Abnormal ventriculo-arterial connection (HP:0011563)	2.13349430
72	Transposition of the great arteries (HP:0001669)	2.13349430
73	Abnormal connection of the cardiac segments (HP:0011545)	2.13349430
74	Insulin-resistant diabetes mellitus (HP:0000831)	2.12070954
75	Retinal dysplasia (HP:0007973)	2.10754066
76	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.06420960
77	Ventricular tachycardia (HP:0004756)	2.02298453
78	Abnormality of the parathyroid morphology (HP:0011766)	2.01917416
79	Flattened epiphyses (HP:0003071)	2.00966675
80	Menstrual irregularities (HP:0000858)	1.99839310
81	Renal Fanconi syndrome (HP:0001994)	1.99141612
82	Recurrent corneal erosions (HP:0000495)	1.98396175
83	Hyponatremia (HP:0002902)	1.96909470
84	Intellectual disability, moderate (HP:0002342)	1.95276193
85	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.93839715
86	Abnormality of femoral epiphyses (HP:0006499)	1.93839715
87	Occipital encephalocele (HP:0002085)	1.93354703
88	Decreased central vision (HP:0007663)	1.90491671
89	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.89678709
90	Tubular atrophy (HP:0000092)	1.88276474
91	Bronchiectasis (HP:0002110)	1.88201475
92	Short ribs (HP:0000773)	1.85949469
93	Recurrent pneumonia (HP:0006532)	1.85322076
94	Anterior segment dysgenesis (HP:0007700)	1.84863627
95	Cerebellar dysplasia (HP:0007033)	1.84403996
96	Tetany (HP:0001281)	1.84397285
97	Abnormality of the femoral head (HP:0003368)	1.83364750
98	Flat capital femoral epiphysis (HP:0003370)	1.81444944
99	Protuberant abdomen (HP:0001538)	1.81071934
100	Photophobia (HP:0000613)	1.77332246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.91542587
2	TESK1	6.48460414
3	DDR2	5.56512395
4	PLK2	3.39492809
5	INSRR	3.20132758
6	STK38	3.10449867
7	MAP4K2	2.57455939
8	MAPK15	2.52441819
9	PNCK	2.35646223
10	BRD4	2.31990992
11	STK38L	2.17597544
12	CAMK1G	1.96650896
13	MST1R	1.82603992
14	PRKD3	1.70847386
15	PDPK1	1.57447604
16	PDK1	1.45938780
17	PIK3CG	1.43909883
18	WNK1	1.43679671
19	CDK19	1.39884015
20	CDK7	1.36086667
21	DYRK1B	1.20053290
22	PTK2B	1.19445456
23	KSR2	1.10289358
24	NEK6	0.98199303
25	CDK12	0.95494587
26	TESK2	0.84665031
27	AKT3	0.83053761
28	SIK2	0.81472301
29	MAP3K9	0.79571498
30	MAP3K2	0.76414957
31	UHMK1	0.75729847
32	PRKG1	0.75497932
33	RPS6KA2	0.75473357
34	WNK4	0.73409744
35	TAOK3	0.73086533
36	CAMK1D	0.72138550
37	MAP3K11	0.69817744
38	PRKG2	0.68573216
39	RIPK4	0.66906060
40	RPS6KA1	0.66435328
41	BRAF	0.64717929
42	PRKAA2	0.62549191
43	MAP2K2	0.61104535
44	JAK3	0.56518709
45	MUSK	0.55602928
46	LATS2	0.55583019
47	BMPR1B	0.51381561
48	MAP3K13	0.50244686
49	STK39	0.49657263
50	ADRBK2	0.48212225
51	ROCK1	0.47128148
52	OXSR1	0.46741207
53	LATS1	0.46549574
54	MET	0.45700510
55	CDK3	0.45595305
56	MAP3K8	0.45503151
57	CDK2	0.43584253
58	RPS6KL1	0.41724334
59	RPS6KC1	0.41724334
60	CAMK1	0.41423893
61	RPS6KA6	0.41125238
62	ARAF	0.41077450
63	MAPK1	0.40062663
64	GSK3B	0.40037411
65	CDK1	0.36012862
66	MAPK11	0.33354847
67	NTRK3	0.33049714
68	TYRO3	0.32700148
69	PRKCG	0.32435439
70	FRK	0.32165158
71	PRKCZ	0.31978463
72	MAPK8	0.31701700
73	CDK4	0.30317411
74	SGK223	0.30179310
75	SGK494	0.30179310
76	MAP3K1	0.29843030
77	PRKCB	0.29349347
78	SGK1	0.27808908
79	MAP3K4	0.26910524
80	CHEK1	0.25942949
81	IKBKB	0.25565830
82	MTOR	0.24427621
83	FER	0.23618536
84	MARK1	0.22487916
85	CHUK	0.21307739
86	MAPK14	0.20514099
87	ZAK	0.19399376
88	CAMK4	0.18024892
89	TIE1	0.16216045
90	MAPK10	0.15058581
91	KIT	0.15047445
92	BRSK1	0.14296566
93	PKN1	0.14032835
94	PRKCE	0.12885780
95	MAP3K7	0.11659879
96	AKT1	0.10680526
97	PRKACB	0.10171363
98	NUAK1	0.09782514
99	TXK	0.09662328
100	PRKCQ	0.09148143

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.31974398
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.81722807
3	Olfactory transduction_Homo sapiens_hsa04740	4.10007093
4	Butanoate metabolism_Homo sapiens_hsa00650	2.39740157
5	Allograft rejection_Homo sapiens_hsa05330	2.24986529
6	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.18469681
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.18275891
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.16585323
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.09269733
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.06856404
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.79923745
12	Taste transduction_Homo sapiens_hsa04742	1.73729995
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.67236931
14	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.60636947
15	Type II diabetes mellitus_Homo sapiens_hsa04930	1.48158476
16	Phototransduction_Homo sapiens_hsa04744	1.46990718
17	Fatty acid degradation_Homo sapiens_hsa00071	1.46789963
18	Viral myocarditis_Homo sapiens_hsa05416	1.46263112
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.45045305
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.36604757
21	RNA transport_Homo sapiens_hsa03013	1.33458880
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.30162708
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26087853
24	Protein digestion and absorption_Homo sapiens_hsa04974	1.24050673
25	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.22388496
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.22330809
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.15623644
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.09133388
29	Endocytosis_Homo sapiens_hsa04144	1.01085126
30	Salivary secretion_Homo sapiens_hsa04970	1.01050226
31	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.96769110
32	ABC transporters_Homo sapiens_hsa02010	0.94994663
33	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.93187579
34	Oocyte meiosis_Homo sapiens_hsa04114	0.91503276
35	Renin-angiotensin system_Homo sapiens_hsa04614	0.88618621
36	Calcium signaling pathway_Homo sapiens_hsa04020	0.88096483
37	Morphine addiction_Homo sapiens_hsa05032	0.88074395
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83797890
39	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.83753868
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83347457
41	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.82790012
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81295882
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80944854
44	Circadian entrainment_Homo sapiens_hsa04713	0.78840357
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.77729538
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.76772446
47	Nicotine addiction_Homo sapiens_hsa05033	0.76086545
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.76040672
49	Arginine biosynthesis_Homo sapiens_hsa00220	0.75233835
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.75149392
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70985855
52	Influenza A_Homo sapiens_hsa05164	0.70644342
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.67962624
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66022305
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65890553
56	Gastric acid secretion_Homo sapiens_hsa04971	0.65710106
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64872015
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.63883792
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57658720
60	Retinol metabolism_Homo sapiens_hsa00830	0.57650521
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57057674
62	Basal transcription factors_Homo sapiens_hsa03022	0.55932991
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55392463
64	Bile secretion_Homo sapiens_hsa04976	0.52932819
65	Purine metabolism_Homo sapiens_hsa00230	0.52196351
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50899855
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49760038
68	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45962207
69	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45662140
70	Renin secretion_Homo sapiens_hsa04924	0.44875890
71	Acute myeloid leukemia_Homo sapiens_hsa05221	0.44366865
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.43533277
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.40870602
74	Cholinergic synapse_Homo sapiens_hsa04725	0.40471174
75	Herpes simplex infection_Homo sapiens_hsa05168	0.40454786
76	Insulin secretion_Homo sapiens_hsa04911	0.39477450
77	MAPK signaling pathway_Homo sapiens_hsa04010	0.38713718
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38296257
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33647919
80	GABAergic synapse_Homo sapiens_hsa04727	0.32828956
81	Tight junction_Homo sapiens_hsa04530	0.30961244
82	Serotonergic synapse_Homo sapiens_hsa04726	0.29708051
83	Fanconi anemia pathway_Homo sapiens_hsa03460	0.28701130
84	Viral carcinogenesis_Homo sapiens_hsa05203	0.27531462
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27353198
86	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27029800
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26574034
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26558214
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.25367560
90	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.24302766
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23898662
92	Pancreatic secretion_Homo sapiens_hsa04972	0.22677848
93	VEGF signaling pathway_Homo sapiens_hsa04370	0.22256305
94	Prolactin signaling pathway_Homo sapiens_hsa04917	0.21945342
95	Huntingtons disease_Homo sapiens_hsa05016	0.21736988
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.21232078
97	Tryptophan metabolism_Homo sapiens_hsa00380	0.19732909
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.19699299
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.19515655
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.19051343

GOLGA2P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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