ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.81547949
2	regulation of DNA methylation (GO:0044030)	5.94484676
3	retinal cone cell development (GO:0046549)	5.82793272
4	meiotic cell cycle (GO:0051321)	5.47341274
5	proteasome assembly (GO:0043248)	5.43425491
6	regulation of female gonad development (GO:2000194)	5.32378914
7	regulation of acrosome reaction (GO:0060046)	5.32190821
8	regulation of meiosis I (GO:0060631)	5.09959791
9	DNA methylation involved in gamete generation (GO:0043046)	5.05226070
10	positive regulation of histone H3-K4 methylation (GO:0051571)	4.91957146
11	multicellular organism reproduction (GO:0032504)	4.86356865
12	neuron fate determination (GO:0048664)	4.78698649
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.77558800
14	glycine transport (GO:0015816)	4.52219587
15	male meiosis I (GO:0007141)	4.16133070
16	female gamete generation (GO:0007292)	3.93951807
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.92026084
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.92026084
19	attachment of spindle microtubules to kinetochore (GO:0008608)	3.91845783
20	synapsis (GO:0007129)	3.78582295
21	meiosis I (GO:0007127)	3.57606087
22	regulation of mitochondrial translation (GO:0070129)	3.54328935
23	male meiosis (GO:0007140)	3.50930958
24	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.50739238
25	gene silencing by RNA (GO:0031047)	3.45522120
26	regulation of steroid hormone secretion (GO:2000831)	3.41378458
27	oocyte development (GO:0048599)	3.41029148
28	chromosome organization involved in meiosis (GO:0070192)	3.38318615
29	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	3.31107384
30	CENP-A containing nucleosome assembly (GO:0034080)	3.29193272
31	mitotic metaphase plate congression (GO:0007080)	3.25494474
32	meiotic nuclear division (GO:0007126)	3.21366762
33	reproduction (GO:0000003)	3.18143074
34	regulation of female receptivity (GO:0045924)	3.10488186
35	negative regulation of reproductive process (GO:2000242)	3.10031832
36	DNA alkylation (GO:0006305)	3.07337051
37	DNA methylation (GO:0006306)	3.07337051
38	chromatin remodeling at centromere (GO:0031055)	3.07147208
39	DNA damage response, detection of DNA damage (GO:0042769)	3.05591230
40	regulation of histone H3-K9 methylation (GO:0051570)	3.05493897
41	synaptonemal complex assembly (GO:0007130)	3.03913281
42	phosphorelay signal transduction system (GO:0000160)	2.94481061
43	epithelial cilium movement (GO:0003351)	2.88358683
44	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.87374348
45	termination of RNA polymerase I transcription (GO:0006363)	2.87352362
46	meiotic cell cycle process (GO:1903046)	2.86319472
47	centriole replication (GO:0007099)	2.83824979
48	synaptonemal complex organization (GO:0070193)	2.83497060
49	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.81752766
50	fertilization (GO:0009566)	2.80872489
51	protein localization to kinetochore (GO:0034501)	2.80838912
52	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	2.79887800
53	tRNA processing (GO:0008033)	2.78635724
54	positive regulation of DNA-templated transcription, initiation (GO:2000144)	2.78406934
55	binding of sperm to zona pellucida (GO:0007339)	2.74199840
56	regulation of cell maturation (GO:1903429)	2.71983001
57	DNA damage induced protein phosphorylation (GO:0006975)	2.70496697
58	cerebral cortex neuron differentiation (GO:0021895)	2.68255943
59	single fertilization (GO:0007338)	2.67223321
60	nucleotide transmembrane transport (GO:1901679)	2.66868813
61	metaphase plate congression (GO:0051310)	2.66769957
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65672012
63	DNA methylation or demethylation (GO:0044728)	2.65297530
64	histone exchange (GO:0043486)	2.63998425
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.63737613
66	positive regulation of histone methylation (GO:0031062)	2.63679448
67	chromatin assembly (GO:0031497)	2.61441330
68	protein kinase C signaling (GO:0070528)	2.60768571
69	transcription from mitochondrial promoter (GO:0006390)	2.60540741
70	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.59159380
71	regulation of corticosteroid hormone secretion (GO:2000846)	2.58695722
72	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.55642795
73	regulation of mitotic spindle checkpoint (GO:1903504)	2.55642795
74	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.55603679
75	tRNA metabolic process (GO:0006399)	2.55550680
76	cilium or flagellum-dependent cell motility (GO:0001539)	2.54507211
77	meiotic chromosome segregation (GO:0045132)	2.53011142
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52778371
79	behavioral response to cocaine (GO:0048148)	2.52569309
80	centriole assembly (GO:0098534)	2.52540198
81	respiratory chain complex IV assembly (GO:0008535)	2.52439389
82	mitotic chromosome condensation (GO:0007076)	2.50904532
83	regulation of helicase activity (GO:0051095)	2.50893979
84	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.50271785
85	female mating behavior (GO:0060180)	2.50149546
86	regulation of spindle checkpoint (GO:0090231)	2.49094228
87	base-excision repair, AP site formation (GO:0006285)	2.48927368
88	protein localization to cilium (GO:0061512)	2.47949668
89	positive regulation of gastrulation (GO:2000543)	2.47929704
90	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.47758017
91	regulation of DNA-templated transcription, initiation (GO:2000142)	2.46127865
92	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.45990969
93	positive regulation of reproductive process (GO:2000243)	2.45967772
94	sperm-egg recognition (GO:0035036)	2.44971833
95	transcription from RNA polymerase I promoter (GO:0006360)	2.44362886
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44244428
97	detection of light stimulus involved in sensory perception (GO:0050962)	2.42958058
98	detection of light stimulus involved in visual perception (GO:0050908)	2.42958058
99	regulation of development, heterochronic (GO:0040034)	2.42726324
100	regulation of timing of cell differentiation (GO:0048505)	2.41579182

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.79358775
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.51212772
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.27360870
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.19063538
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.70150693
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40539029
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.37344244
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.37344244
9	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.37344244
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34511705
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31305377
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.18032838
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17360671
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.11752704
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07514975
16	FUS_26573619_Chip-Seq_HEK293_Human	1.93301832
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80455192
18	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.80181855
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.79135394
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77984745
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.74919323
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72382584
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.71768475
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.67931870
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67931870
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.60671526
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56088077
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53300205
29	VDR_22108803_ChIP-Seq_LS180_Human	1.51532477
30	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.50840888
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49852037
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47565255
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47354561
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45444100
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45433093
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.45370517
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.44924296
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.44826124
39	EWS_26573619_Chip-Seq_HEK293_Human	1.43965717
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40668282
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37902985
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.36717879
43	P300_19829295_ChIP-Seq_ESCs_Human	1.28394822
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28249798
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25711925
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.25083322
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.24740227
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24335318
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24185400
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22730675
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20956664
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20256352
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.18501908
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.17918644
55	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14112105
56	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13001802
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10319644
58	AR_20517297_ChIP-Seq_VCAP_Human	1.08500608
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08290509
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07473121
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05300894
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04513735
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03492230
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03467008
65	AR_25329375_ChIP-Seq_VCAP_Human	1.00906219
66	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.98853313
67	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.98697724
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98575460
69	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97019889
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96904974
71	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96599523
72	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96341042
73	NCOR_22424771_ChIP-Seq_293T_Human	0.96286001
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95838107
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93845930
76	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.93250557
77	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93103061
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.92023154
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91836235
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91570969
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91570969
82	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.91538325
83	DCP1A_22483619_ChIP-Seq_HELA_Human	0.91141232
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90872958
85	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.90451673
86	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88447696
87	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.88031809
88	TTF2_22483619_ChIP-Seq_HELA_Human	0.87393592
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.87367992
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87367992
91	STAT3_23295773_ChIP-Seq_U87_Human	0.87016587
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86653520
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86182811
94	KDM5A_27292631_Chip-Seq_BREAST_Human	0.85036268
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84782484
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84282997
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84282997
98	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.83071836
99	TCF4_23295773_ChIP-Seq_U87_Human	0.82974978
100	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.82826962

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.59839977
2	MP0003718_maternal_effect	4.35334398
3	MP0008789_abnormal_olfactory_epithelium	4.33569669
4	MP0008877_abnormal_DNA_methylation	3.80172501
5	MP0005499_abnormal_olfactory_system	3.79725124
6	MP0005394_taste/olfaction_phenotype	3.79725124
7	MP0002234_abnormal_pharynx_morphology	3.12522023
8	MP0003879_abnormal_hair_cell	2.90945126
9	MP0001986_abnormal_taste_sensitivity	2.61466459
10	MP0003136_yellow_coat_color	2.50908595
11	MP0009780_abnormal_chondrocyte_physiolo	2.37914263
12	MP0008057_abnormal_DNA_replication	2.18384755
13	MP0008058_abnormal_DNA_repair	2.16257984
14	MP0000049_abnormal_middle_ear	2.10866402
15	MP0003183_abnormal_peptide_metabolism	2.01934947
16	MP0003941_abnormal_skin_development	2.00626938
17	MP0003938_abnormal_ear_development	1.97097834
18	MP0002653_abnormal_ependyma_morphology	1.87044055
19	MP0010030_abnormal_orbit_morphology	1.84702014
20	MP0000678_abnormal_parathyroid_gland	1.83888759
21	MP0000631_abnormal_neuroendocrine_gland	1.73888707
22	MP0003121_genomic_imprinting	1.67387113
23	MP0005395_other_phenotype	1.66338397
24	MP0005646_abnormal_pituitary_gland	1.64172597
25	MP0003880_abnormal_central_pattern	1.61532142
26	MP0006276_abnormal_autonomic_nervous	1.60733706
27	MP0001929_abnormal_gametogenesis	1.58748594
28	MP0004142_abnormal_muscle_tone	1.55983907
29	MP0002233_abnormal_nose_morphology	1.53757084
30	MP0002210_abnormal_sex_determination	1.53754592
31	MP0002638_abnormal_pupillary_reflex	1.48957297
32	MP0003787_abnormal_imprinting	1.45678827
33	MP0002102_abnormal_ear_morphology	1.42598735
34	MP0010094_abnormal_chromosome_stability	1.39305112
35	MP0002090_abnormal_vision	1.36306652
36	MP0003699_abnormal_female_reproductive	1.32771081
37	MP0005551_abnormal_eye_electrophysiolog	1.30130882
38	MP0003077_abnormal_cell_cycle	1.29323434
39	MP0000653_abnormal_sex_gland	1.27008546
40	MP0003693_abnormal_embryo_hatching	1.22663249
41	MP0005410_abnormal_fertilization	1.21222178
42	MP0001293_anophthalmia	1.17848003
43	MP0005367_renal/urinary_system_phenotyp	1.14475687
44	MP0000516_abnormal_urinary_system	1.14475687
45	MP0003122_maternal_imprinting	1.11215131
46	MP0000026_abnormal_inner_ear	1.10542002
47	MP0002098_abnormal_vibrissa_morphology	1.10495427
48	MP0003111_abnormal_nucleus_morphology	1.08287924
49	MP0002160_abnormal_reproductive_system	1.07255517
50	MP0003119_abnormal_digestive_system	1.06431280
51	MP0001145_abnormal_male_reproductive	1.06186122
52	MP0002161_abnormal_fertility/fecundity	1.06140918
53	MP0009379_abnormal_foot_pigmentation	1.05522905
54	MP0003755_abnormal_palate_morphology	1.04230879
55	MP0002272_abnormal_nervous_system	1.03269531
56	MP0003698_abnormal_male_reproductive	1.03058854
57	MP0008932_abnormal_embryonic_tissue	1.00645832
58	MP0000372_irregular_coat_pigmentation	0.97226766
59	MP0004885_abnormal_endolymph	0.95279631
60	MP0000566_synostosis	0.93796859
61	MP0001963_abnormal_hearing_physiology	0.93132762
62	MP0009046_muscle_twitch	0.92386606
63	MP0001529_abnormal_vocalization	0.92152391
64	MP0003890_abnormal_embryonic-extraembry	0.91716540
65	MP0001119_abnormal_female_reproductive	0.87818413
66	MP0003646_muscle_fatigue	0.86966952
67	MP0002139_abnormal_hepatobiliary_system	0.86150347
68	MP0002876_abnormal_thyroid_physiology	0.83223837
69	MP0001286_abnormal_eye_development	0.83103601
70	MP0000383_abnormal_hair_follicle	0.82194471
71	MP0006072_abnormal_retinal_apoptosis	0.81669755
72	MP0001905_abnormal_dopamine_level	0.81071355
73	MP0002249_abnormal_larynx_morphology	0.80407261
74	MP0009745_abnormal_behavioral_response	0.79848420
75	MP0005248_abnormal_Harderian_gland	0.78990604
76	MP0001486_abnormal_startle_reflex	0.78824031
77	MP0002909_abnormal_adrenal_gland	0.78239968
78	MP0005187_abnormal_penis_morphology	0.78119785
79	MP0005389_reproductive_system_phenotype	0.77386948
80	MP0001485_abnormal_pinna_reflex	0.76626603
81	MP0002177_abnormal_outer_ear	0.74912286
82	MP0000750_abnormal_muscle_regeneration	0.72852364
83	MP0008995_early_reproductive_senescence	0.72322664
84	MP0003123_paternal_imprinting	0.71813602
85	MP0001984_abnormal_olfaction	0.71640463
86	MP0001764_abnormal_homeostasis	0.66240335
87	MP0000428_abnormal_craniofacial_morphol	0.65879200
88	MP0004233_abnormal_muscle_weight	0.65351130
89	MP0000681_abnormal_thyroid_gland	0.61890561
90	MP0002138_abnormal_hepatobiliary_system	0.61167910
91	MP0002163_abnormal_gland_morphology	0.59144746
92	MP0005253_abnormal_eye_physiology	0.58385766
93	MP0002938_white_spotting	0.57761082
94	MP0005195_abnormal_posterior_eye	0.56327733
95	MP0002735_abnormal_chemical_nociception	0.56104445
96	MP0010678_abnormal_skin_adnexa	0.53157783
97	MP0003195_calcinosis	0.52626728
98	MP0003937_abnormal_limbs/digits/tail_de	0.51567890
99	MP0001664_abnormal_digestion	0.51325525
100	MP0003950_abnormal_plasma_membrane	0.50309727

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	4.21628461
2	Male infertility (HP:0003251)	3.44730337
3	Bile duct proliferation (HP:0001408)	3.37955595
4	Abnormal biliary tract physiology (HP:0012439)	3.37955595
5	Hypokinesia (HP:0002375)	3.23117655
6	Oligodactyly (hands) (HP:0001180)	3.21558850
7	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.09545615
8	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.08578851
9	Hypoplasia of the fovea (HP:0007750)	3.08578851
10	Absent septum pellucidum (HP:0001331)	3.03142026
11	Supernumerary spleens (HP:0009799)	2.98605343
12	Abnormality of midbrain morphology (HP:0002418)	2.96945941
13	Molar tooth sign on MRI (HP:0002419)	2.96945941
14	Delayed CNS myelination (HP:0002188)	2.95834914
15	Azoospermia (HP:0000027)	2.93546730
16	Osteomalacia (HP:0002749)	2.83403461
17	3-Methylglutaconic aciduria (HP:0003535)	2.82282394
18	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.79635834
19	Optic nerve hypoplasia (HP:0000609)	2.76035582
20	Median cleft lip (HP:0000161)	2.75032121
21	Abnormality of the fovea (HP:0000493)	2.68161442
22	Abnormality of the labia minora (HP:0012880)	2.67805085
23	Medial flaring of the eyebrow (HP:0010747)	2.61413336
24	Delayed myelination (HP:0012448)	2.61207271
25	Premature ovarian failure (HP:0008209)	2.60313673
26	Oligodactyly (HP:0012165)	2.59836562
27	Gonadotropin excess (HP:0000837)	2.59670685
28	Abnormal ciliary motility (HP:0012262)	2.57288823
29	Progressive inability to walk (HP:0002505)	2.53518750
30	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.52208135
31	Facial hemangioma (HP:0000329)	2.45821920
32	Congenital primary aphakia (HP:0007707)	2.44235530
33	Atonic seizures (HP:0010819)	2.39132943
34	Gait imbalance (HP:0002141)	2.39024666
35	Absent/shortened dynein arms (HP:0200106)	2.37672012
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.37672012
37	Maternal diabetes (HP:0009800)	2.36827674
38	Pancreatic cysts (HP:0001737)	2.36724810
39	Chronic hepatic failure (HP:0100626)	2.35405891
40	Abnormal gallbladder physiology (HP:0012438)	2.34859653
41	Cholecystitis (HP:0001082)	2.34859653
42	Abnormality of the septum pellucidum (HP:0007375)	2.34645312
43	True hermaphroditism (HP:0010459)	2.33895468
44	Nephrogenic diabetes insipidus (HP:0009806)	2.27705604
45	Enlarged penis (HP:0000040)	2.27097821
46	Anterior segment dysgenesis (HP:0007700)	2.26108199
47	Pancreatic fibrosis (HP:0100732)	2.25844141
48	Infertility (HP:0000789)	2.24341987
49	Poor eye contact (HP:0000817)	2.22791649
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21291182
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.21291182
52	Microvesicular hepatic steatosis (HP:0001414)	2.20902655
53	Hypoglycemic coma (HP:0001325)	2.20793254
54	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.20345878
55	Hypophosphatemic rickets (HP:0004912)	2.17696039
56	Lip pit (HP:0100267)	2.17304473
57	Tubulointerstitial nephritis (HP:0001970)	2.17053127
58	Abnormal spermatogenesis (HP:0008669)	2.16390949
59	Prominent metopic ridge (HP:0005487)	2.09355092
60	Genital tract atresia (HP:0001827)	2.09083314
61	Diminished movement (HP:0002374)	2.07915200
62	Increased hepatocellular lipid droplets (HP:0006565)	2.04854143
63	Acute encephalopathy (HP:0006846)	2.03326916
64	Hypothermia (HP:0002045)	2.01162279
65	Increased serum lactate (HP:0002151)	1.98298882
66	Abnormality of the metopic suture (HP:0005556)	1.98031733
67	Unsteady gait (HP:0002317)	1.96743510
68	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.94408802
69	Impulsivity (HP:0100710)	1.94000376
70	Generalized aminoaciduria (HP:0002909)	1.92176605
71	Abdominal situs inversus (HP:0003363)	1.88963333
72	Abnormality of abdominal situs (HP:0011620)	1.88963333
73	Hepatic necrosis (HP:0002605)	1.87687831
74	Dialeptic seizures (HP:0011146)	1.87209952
75	Increased CSF lactate (HP:0002490)	1.86786202
76	Hyperactive renin-angiotensin system (HP:0000841)	1.86282137
77	Methylmalonic acidemia (HP:0002912)	1.86024697
78	Dyskinesia (HP:0100660)	1.85065067
79	Lipid accumulation in hepatocytes (HP:0006561)	1.84535506
80	Limb hypertonia (HP:0002509)	1.82976860
81	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82013580
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81615347
83	Abnormality of alanine metabolism (HP:0010916)	1.81615347
84	Hyperalaninemia (HP:0003348)	1.81615347
85	Absence seizures (HP:0002121)	1.81603374
86	Thyroid-stimulating hormone excess (HP:0002925)	1.81590758
87	Vaginal atresia (HP:0000148)	1.81353708
88	Postaxial foot polydactyly (HP:0001830)	1.81266882
89	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.80996018
90	Papillary thyroid carcinoma (HP:0002895)	1.79322320
91	Palpebral edema (HP:0100540)	1.79163859
92	Sclerocornea (HP:0000647)	1.77706850
93	Proximal tubulopathy (HP:0000114)	1.76270224
94	Hyperglycinemia (HP:0002154)	1.75133202
95	Congenital stationary night blindness (HP:0007642)	1.74684546
96	Abnormality of the antihelix (HP:0009738)	1.73818455
97	Nephronophthisis (HP:0000090)	1.73354440
98	Decreased circulating renin level (HP:0003351)	1.71104242
99	Acute necrotizing encephalopathy (HP:0006965)	1.70431992
100	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.68172557

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	7.27528926
2	MAP4K2	6.21532851
3	TRIM28	4.72390922
4	INSRR	2.33092257
5	MUSK	2.24199171
6	PLK2	2.19858671
7	NUAK1	2.08064231
8	VRK2	1.92282108
9	PIM2	1.80764388
10	NEK6	1.79840311
11	BMPR1B	1.78592056
12	FRK	1.77734470
13	MAPK13	1.61998627
14	CSNK1G3	1.56692230
15	PRKCI	1.47864394
16	CSNK1G1	1.45033132
17	CSNK1A1L	1.44534348
18	CDK8	1.42630072
19	ZAK	1.37479334
20	BUB1	1.37131434
21	NME1	1.36912648
22	TNIK	1.31007952
23	WNK3	1.26990098
24	TTK	1.26154966
25	STK38L	1.25603260
26	CDC7	1.25198268
27	CDK9	1.24917631
28	PRKD3	1.23494317
29	CSNK1G2	1.20568189
30	MET	1.18613944
31	MAP3K9	1.18397876
32	MST4	1.14954450
33	BCR	1.13715246
34	ARAF	1.11887052
35	MAP3K12	1.10007541
36	STK16	1.08561549
37	EPHA4	1.06007370
38	PLK1	1.02420948
39	PDK2	0.99502244
40	AURKA	0.98743715
41	DYRK2	0.96616756
42	NTRK2	0.95081655
43	VRK1	0.94624572
44	CDK7	0.93168670
45	MAPKAPK3	0.92016344
46	DYRK1B	0.90352823
47	MAP3K5	0.88393802
48	OXSR1	0.83972604
49	PLK3	0.82534609
50	GRK1	0.79776383
51	MAP3K4	0.79109809
52	TSSK6	0.76190781
53	SRPK1	0.73638189
54	PRKCE	0.73180272
55	MAP2K7	0.66825324
56	AURKB	0.66565076
57	TAOK3	0.66268171
58	EPHA2	0.65170581
59	CDK12	0.61529129
60	MELK	0.60027059
61	CHEK1	0.59430109
62	BRSK1	0.59020560
63	BRAF	0.58107004
64	AKT3	0.56764323
65	TIE1	0.53095982
66	ADRBK2	0.51649012
67	PIM1	0.51291716
68	PIK3CA	0.47913056
69	PLK4	0.47786798
70	CDK11A	0.46028285
71	CSNK1A1	0.45500807
72	ATM	0.44869917
73	STK39	0.43806277
74	CCNB1	0.41871284
75	CASK	0.41091933
76	CAMK2A	0.40739876
77	CSNK1D	0.39844568
78	MYLK	0.39721254
79	STK24	0.38537014
80	STK3	0.37499165
81	CSNK1E	0.37459070
82	CDK14	0.36696380
83	LIMK1	0.36541587
84	AKT2	0.35457493
85	CHEK2	0.35429673
86	PTK2	0.34122586
87	TGFBR1	0.33577398
88	PRKACB	0.33318412
89	CDK2	0.32888566
90	PINK1	0.32563492
91	MAPKAPK5	0.32522599
92	FER	0.31988409
93	EEF2K	0.31769788
94	ATR	0.31744550
95	CDK5	0.31363133
96	SIK3	0.30979027
97	RAF1	0.30947818
98	DMPK	0.29140547
99	PRKAA1	0.29072053
100	DAPK3	0.28751387

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.26092914
2	RNA polymerase_Homo sapiens_hsa03020	2.68663579
3	Mismatch repair_Homo sapiens_hsa03430	2.62073952
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.50570736
5	Proteasome_Homo sapiens_hsa03050	2.40377285
6	Phototransduction_Homo sapiens_hsa04744	2.39172801
7	Homologous recombination_Homo sapiens_hsa03440	2.20456263
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10956761
9	Cell cycle_Homo sapiens_hsa04110	2.09223532
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.09087077
11	RNA degradation_Homo sapiens_hsa03018	1.91054789
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.88652392
13	Nicotine addiction_Homo sapiens_hsa05033	1.88150245
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87913844
15	Oocyte meiosis_Homo sapiens_hsa04114	1.83199294
16	Parkinsons disease_Homo sapiens_hsa05012	1.81809839
17	Folate biosynthesis_Homo sapiens_hsa00790	1.78700259
18	Huntingtons disease_Homo sapiens_hsa05016	1.77305008
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.76148997
20	RNA transport_Homo sapiens_hsa03013	1.72606312
21	Protein export_Homo sapiens_hsa03060	1.71621380
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.60822006
23	Base excision repair_Homo sapiens_hsa03410	1.60387356
24	DNA replication_Homo sapiens_hsa03030	1.55939524
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.53832462
26	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.53782698
27	Olfactory transduction_Homo sapiens_hsa04740	1.44839656
28	Butanoate metabolism_Homo sapiens_hsa00650	1.42915943
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42154780
30	Propanoate metabolism_Homo sapiens_hsa00640	1.40183195
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38313720
32	Caffeine metabolism_Homo sapiens_hsa00232	1.38266029
33	Circadian rhythm_Homo sapiens_hsa04710	1.37963793
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33408965
35	Spliceosome_Homo sapiens_hsa03040	1.26959379
36	GABAergic synapse_Homo sapiens_hsa04727	1.26748359
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.22867822
38	p53 signaling pathway_Homo sapiens_hsa04115	1.21233414
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.20360491
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20308538
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.14134012
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12258223
43	Taste transduction_Homo sapiens_hsa04742	1.11603302
44	Fatty acid elongation_Homo sapiens_hsa00062	1.03250260
45	Morphine addiction_Homo sapiens_hsa05032	1.01209881
46	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.98536476
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96552336
48	Alzheimers disease_Homo sapiens_hsa05010	0.91491302
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.90860198
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90461379
51	Purine metabolism_Homo sapiens_hsa00230	0.88277248
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.88069739
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86374062
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.83108266
55	Peroxisome_Homo sapiens_hsa04146	0.81229404
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.79907465
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77641132
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77332934
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.75778790
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.74188955
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73836589
62	Ribosome_Homo sapiens_hsa03010	0.69971450
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69125730
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68109040
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.66818979
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63160436
67	One carbon pool by folate_Homo sapiens_hsa00670	0.62421851
68	Metabolic pathways_Homo sapiens_hsa01100	0.61715166
69	Glutathione metabolism_Homo sapiens_hsa00480	0.61153298
70	Retinol metabolism_Homo sapiens_hsa00830	0.59039431
71	ABC transporters_Homo sapiens_hsa02010	0.58447729
72	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.58431504
73	Sulfur relay system_Homo sapiens_hsa04122	0.56587634
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.55010442
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54513075
76	Regulation of autophagy_Homo sapiens_hsa04140	0.54073981
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54050325
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53018116
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.52595795
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50730845
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48831789
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48807072
83	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48023468
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46658382
85	Insulin secretion_Homo sapiens_hsa04911	0.45697436
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45246236
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43862712
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43187359
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43130268
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41427674
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40105654
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.39657428
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38357767
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38317300
95	Salivary secretion_Homo sapiens_hsa04970	0.37649029
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36182352
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.35834759
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.35250466
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33530928
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27749717

GOLGA2P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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