ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.99714045
2	sperm motility (GO:0030317)	9.59718102
3	fusion of sperm to egg plasma membrane (GO:0007342)	9.47867978
4	response to pheromone (GO:0019236)	8.80040544
5	plasma membrane fusion (GO:0045026)	7.27649758
6	single strand break repair (GO:0000012)	6.95126104
7	sperm capacitation (GO:0048240)	6.91230687
8	microtubule depolymerization (GO:0007019)	6.62924195
9	spermatid development (GO:0007286)	6.62518268
10	chromosome condensation (GO:0030261)	6.42762063
11	sperm-egg recognition (GO:0035036)	6.35446776
12	DNA packaging (GO:0006323)	6.31622325
13	multicellular organism reproduction (GO:0032504)	6.14935498
14	calcium ion-dependent exocytosis (GO:0017156)	5.89740519
15	microtubule polymerization or depolymerization (GO:0031109)	5.72054487
16	spermatid nucleus differentiation (GO:0007289)	5.69429902
17	binding of sperm to zona pellucida (GO:0007339)	5.66178256
18	protein polyglutamylation (GO:0018095)	5.60765414
19	reproduction (GO:0000003)	5.39462262
20	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.31128045
21	rRNA methylation (GO:0031167)	5.26457248
22	cell-cell recognition (GO:0009988)	5.25746362
23	cellular ketone body metabolic process (GO:0046950)	5.17761479
24	phosphatidylethanolamine metabolic process (GO:0046337)	5.08005039
25	spermatogenesis (GO:0007283)	5.07942555
26	male gamete generation (GO:0048232)	5.07034436
27	microtubule severing (GO:0051013)	5.03331542
28	centriole replication (GO:0007099)	5.01774134
29	establishment of protein localization to Golgi (GO:0072600)	5.01612085
30	negative regulation of inclusion body assembly (GO:0090084)	4.96908742
31	axonemal dynein complex assembly (GO:0070286)	4.91513064
32	regulation of cilium movement (GO:0003352)	4.85012836
33	protein targeting to Golgi (GO:0000042)	4.84698447
34	gamete generation (GO:0007276)	4.68310454
35	cilium or flagellum-dependent cell motility (GO:0001539)	4.58414271
36	ketone body metabolic process (GO:1902224)	4.54119376
37	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.50009592
38	rRNA modification (GO:0000154)	4.37381115
39	centriole assembly (GO:0098534)	4.36154312
40	NAD biosynthetic process (GO:0009435)	4.32140699
41	regulation of Rab GTPase activity (GO:0032313)	4.25394028
42	positive regulation of Rab GTPase activity (GO:0032851)	4.25394028
43	regulation of transcription involved in cell fate commitment (GO:0060850)	4.18802463
44	sexual reproduction (GO:0019953)	4.16246449
45	cell wall macromolecule metabolic process (GO:0044036)	4.11468063
46	motile cilium assembly (GO:0044458)	4.07842636
47	peptidyl-threonine dephosphorylation (GO:0035970)	4.01159813
48	cell wall macromolecule catabolic process (GO:0016998)	3.93147837
49	germ cell development (GO:0007281)	3.91929418
50	coenzyme catabolic process (GO:0009109)	3.84499492
51	single fertilization (GO:0007338)	3.80895350
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.70093966
53	multicellular organismal reproductive process (GO:0048609)	3.69147805
54	epithelial cilium movement (GO:0003351)	3.61136306
55	regulation of female gonad development (GO:2000194)	3.61019645
56	chromatin silencing (GO:0006342)	3.59907312
57	protein localization to Golgi apparatus (GO:0034067)	3.56350672
58	musculoskeletal movement (GO:0050881)	3.55097162
59	multicellular organismal movement (GO:0050879)	3.55097162
60	RNA destabilization (GO:0050779)	3.50475464
61	seminiferous tubule development (GO:0072520)	3.45840023
62	fertilization (GO:0009566)	3.44790911
63	cellular biogenic amine biosynthetic process (GO:0042401)	3.34587637
64	piRNA metabolic process (GO:0034587)	3.31328543
65	regulation of microtubule-based movement (GO:0060632)	3.29716123
66	regulation of inclusion body assembly (GO:0090083)	3.28548188
67	cilium movement (GO:0003341)	3.25040796
68	pyridine nucleotide biosynthetic process (GO:0019363)	3.23946178
69	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.23946178
70	male meiosis I (GO:0007141)	3.22867965
71	DNA methylation involved in gamete generation (GO:0043046)	3.21663208
72	cellular response to pH (GO:0071467)	3.20426608
73	male meiosis (GO:0007140)	3.17029697
74	amine biosynthetic process (GO:0009309)	3.15417920
75	negative regulation of Rho protein signal transduction (GO:0035024)	3.11942299
76	organic cation transport (GO:0015695)	3.08043375
77	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.05481068
78	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.05481068
79	regulation of translation, ncRNA-mediated (GO:0045974)	3.05481068
80	regulation of centriole replication (GO:0046599)	3.02604593
81	regulation of sarcomere organization (GO:0060297)	3.02531111
82	regulation of meiosis I (GO:0060631)	3.02446784
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.98074896
84	cerebral cortex neuron differentiation (GO:0021895)	2.95725620
85	response to acidic pH (GO:0010447)	2.92618860
86	positive regulation of action potential (GO:0045760)	2.91915710
87	primary amino compound metabolic process (GO:1901160)	2.90919274
88	nucleus organization (GO:0006997)	2.90386870
89	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87122905
90	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.86051639
91	imidazole-containing compound metabolic process (GO:0052803)	2.85784743
92	Golgi to endosome transport (GO:0006895)	2.81726133
93	glycerol ether metabolic process (GO:0006662)	2.79133436
94	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.78743043
95	alanine transport (GO:0032328)	2.77561713
96	nonmotile primary cilium assembly (GO:0035058)	2.76688771
97	cell recognition (GO:0008037)	2.72309151
98	membrane depolarization during action potential (GO:0086010)	2.69969058
99	spinal cord motor neuron differentiation (GO:0021522)	2.68840940
100	multicellular organismal development (GO:0007275)	2.67181906

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.26030467
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.58397044
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.58858858
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54516989
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.54516989
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53459794
7	DROSHA_22980978_ChIP-Seq_HELA_Human	2.42570722
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.31115952
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.09881281
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.09881281
11	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.05904849
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04816469
13	VDR_22108803_ChIP-Seq_LS180_Human	2.03696545
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81895100
15	FUS_26573619_Chip-Seq_HEK293_Human	1.79093685
16	P300_19829295_ChIP-Seq_ESCs_Human	1.77768439
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77031006
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76203407
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.74959306
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69943805
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.65123367
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60218109
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.60025619
24	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.57425625
25	AR_25329375_ChIP-Seq_VCAP_Human	1.55472311
26	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.54142828
27	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.53238167
28	STAT3_23295773_ChIP-Seq_U87_Human	1.51189350
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47004644
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.46568626
31	ERA_21632823_ChIP-Seq_H3396_Human	1.46169582
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.45918385
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.45906979
34	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45813181
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.45781454
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44596948
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42937650
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42061356
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39852251
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38748234
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38322738
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37760894
43	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.37201776
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.36321457
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.36028760
46	OCT4_20526341_ChIP-Seq_ESCs_Human	1.34747027
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33375406
48	MYC_19829295_ChIP-Seq_ESCs_Human	1.33083790
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32154652
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31790125
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31109443
52	TCF4_23295773_ChIP-Seq_U87_Human	1.30277415
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28808620
54	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28326012
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26751554
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.25381898
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24476840
58	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.22551751
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20413182
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19854342
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19519307
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19519307
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19058099
64	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.18139384
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18072135
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.17256588
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16618484
68	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16167252
69	E2F1_20622854_ChIP-Seq_HELA_Human	1.16016765
70	TBL1_22424771_ChIP-Seq_293T_Human	1.15984547
71	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.15900200
72	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.15623477
73	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14233844
74	CTCF_27219007_Chip-Seq_Bcells_Human	1.12206324
75	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12091204
76	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11091496
77	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10960135
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10811452
79	KDM2B_26808549_Chip-Seq_REH_Human	1.09998313
80	NFYB_21822215_ChIP-Seq_K562_Human	1.09602023
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09567529
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.09538047
83	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09188932
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08989230
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08630256
86	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.08043475
87	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07748950
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07259243
89	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07124540
90	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06812595
91	BCL6_27268052_Chip-Seq_Bcells_Human	1.06520285
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.06405609
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.06280472
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06274952
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05446509
96	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03910490
97	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03787511
98	PHF8_20622853_ChIP-Seq_HELA_Human	1.02190047
99	NFYA_21822215_ChIP-Seq_K562_Human	1.01575897
100	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.01182265

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.82505582
2	MP0003878_abnormal_ear_physiology	4.40857398
3	MP0005377_hearing/vestibular/ear_phenot	4.40857398
4	MP0005670_abnormal_white_adipose	3.76121251
5	MP0003698_abnormal_male_reproductive	3.72666974
6	MP0001929_abnormal_gametogenesis	3.28572378
7	MP0002735_abnormal_chemical_nociception	3.08009039
8	MP0001348_abnormal_lacrimal_gland	2.99272362
9	MP0003718_maternal_effect	2.48011626
10	MP0005423_abnormal_somatic_nervous	2.45485012
11	MP0008877_abnormal_DNA_methylation	2.28857933
12	MP0001486_abnormal_startle_reflex	2.06078357
13	MP0001485_abnormal_pinna_reflex	2.03238621
14	MP0002161_abnormal_fertility/fecundity	2.02751245
15	MP0003646_muscle_fatigue	2.01023101
16	MP0000678_abnormal_parathyroid_gland	1.92835942
17	MP0001501_abnormal_sleep_pattern	1.88901179
18	MP0002234_abnormal_pharynx_morphology	1.85255707
19	MP0002733_abnormal_thermal_nociception	1.81841378
20	MP0001968_abnormal_touch/_nociception	1.81830250
21	MP0002210_abnormal_sex_determination	1.80336680
22	MP0002822_catalepsy	1.76520511
23	MP0002734_abnormal_mechanical_nocicepti	1.76368919
24	MP0005551_abnormal_eye_electrophysiolog	1.66758011
25	MP0003880_abnormal_central_pattern	1.63111129
26	MP0009745_abnormal_behavioral_response	1.57953801
27	MP0002572_abnormal_emotion/affect_behav	1.47823040
28	MP0009046_muscle_twitch	1.46666551
29	MP0001970_abnormal_pain_threshold	1.46406649
30	MP0000653_abnormal_sex_gland	1.46392536
31	MP0001145_abnormal_male_reproductive	1.45401133
32	MP0003011_delayed_dark_adaptation	1.38189248
33	MP0003283_abnormal_digestive_organ	1.33284641
34	MP0006276_abnormal_autonomic_nervous	1.26576726
35	MP0002557_abnormal_social/conspecific_i	1.26314801
36	MP0001963_abnormal_hearing_physiology	1.25703831
37	MP0001905_abnormal_dopamine_level	1.25315745
38	MP0006292_abnormal_olfactory_placode	1.25286067
39	MP0009053_abnormal_anal_canal	1.24945084
40	MP0003879_abnormal_hair_cell	1.23815752
41	MP0005083_abnormal_biliary_tract	1.23505254
42	MP0000026_abnormal_inner_ear	1.23152711
43	MP0004859_abnormal_synaptic_plasticity	1.22548191
44	MP0002067_abnormal_sensory_capabilities	1.21476891
45	MP0004742_abnormal_vestibular_system	1.20697636
46	MP0001440_abnormal_grooming_behavior	1.19820377
47	MP0002272_abnormal_nervous_system	1.16713419
48	MP0002249_abnormal_larynx_morphology	1.16640512
49	MP0001765_abnormal_ion_homeostasis	1.14747659
50	MP0005395_other_phenotype	1.14212080
51	MP0003635_abnormal_synaptic_transmissio	1.11558954
52	MP0005310_abnormal_salivary_gland	1.08997320
53	MP0001984_abnormal_olfaction	0.99333111
54	MP0009115_abnormal_fat_cell	0.98042929
55	MP0004085_abnormal_heartbeat	0.94612588
56	MP0005253_abnormal_eye_physiology	0.92736275
57	MP0003119_abnormal_digestive_system	0.92001865
58	MP0002736_abnormal_nociception_after	0.92001095
59	MP0000049_abnormal_middle_ear	0.91079590
60	MP0002229_neurodegeneration	0.90816300
61	MP0005167_abnormal_blood-brain_barrier	0.90707472
62	MP0000955_abnormal_spinal_cord	0.90695504
63	MP0002064_seizures	0.88246197
64	MP0005379_endocrine/exocrine_gland_phen	0.85643128
65	MP0004270_analgesia	0.85166442
66	MP0008569_lethality_at_weaning	0.83467880
67	MP0003787_abnormal_imprinting	0.83314937
68	MP0000534_abnormal_ureter_morphology	0.83151838
69	MP0002282_abnormal_trachea_morphology	0.82342612
70	MP0005647_abnormal_sex_gland	0.79664137
71	MP0008961_abnormal_basal_metabolism	0.79087000
72	MP0002063_abnormal_learning/memory/cond	0.78481767
73	MP0008995_early_reproductive_senescence	0.76091925
74	MP0002127_abnormal_cardiovascular_syste	0.75724143
75	MP0008789_abnormal_olfactory_epithelium	0.73716023
76	MP0003195_calcinosis	0.71941926
77	MP0001879_abnormal_lymphatic_vessel	0.71510363
78	MP0002184_abnormal_innervation	0.69860423
79	MP0002132_abnormal_respiratory_system	0.69363828
80	MP0002928_abnormal_bile_duct	0.64769960
81	MP0002752_abnormal_somatic_nervous	0.64016253
82	MP0009697_abnormal_copulation	0.63411744
83	MP0002882_abnormal_neuron_morphology	0.63084258
84	MP0002138_abnormal_hepatobiliary_system	0.60396968
85	MP0002653_abnormal_ependyma_morphology	0.59796969
86	MP0000569_abnormal_digit_pigmentation	0.59757388
87	MP0004142_abnormal_muscle_tone	0.59205420
88	MP0003699_abnormal_female_reproductive	0.57813990
89	MP0005451_abnormal_body_composition	0.57129708
90	MP0000470_abnormal_stomach_morphology	0.52207637
91	MP0000230_abnormal_systemic_arterial	0.52203614
92	MP0005195_abnormal_posterior_eye	0.51178614
93	MP0003631_nervous_system_phenotype	0.49811938
94	MP0000681_abnormal_thyroid_gland	0.49525582
95	MP0003638_abnormal_response/metabolism_	0.49422937
96	MP0001119_abnormal_female_reproductive	0.49390093
97	MP0005636_abnormal_mineral_homeostasis	0.49187393
98	MP0008872_abnormal_physiological_respon	0.48761728
99	MP0003137_abnormal_impulse_conducting	0.48386622
100	MP0005394_taste/olfaction_phenotype	0.47931723

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.19729595
2	Attenuation of retinal blood vessels (HP:0007843)	5.42014450
3	Absent/shortened dynein arms (HP:0200106)	5.13685435
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.13685435
5	Bony spicule pigmentary retinopathy (HP:0007737)	4.81201760
6	Abnormal rod and cone electroretinograms (HP:0008323)	4.62129105
7	Progressive cerebellar ataxia (HP:0002073)	4.36521364
8	Male infertility (HP:0003251)	4.19534142
9	Hypoplastic ischia (HP:0003175)	4.11455847
10	Retinal dysplasia (HP:0007973)	3.94921197
11	Genetic anticipation (HP:0003743)	3.93001934
12	Abnormal ciliary motility (HP:0012262)	3.89945853
13	Chronic hepatic failure (HP:0100626)	3.85707160
14	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.84566649
15	Abnormality of macular pigmentation (HP:0008002)	3.83835998
16	Bell-shaped thorax (HP:0001591)	3.78682155
17	Abnormality of the ischium (HP:0003174)	3.66179014
18	Abnormal respiratory motile cilium physiology (HP:0012261)	3.64215634
19	Hyperkalemia (HP:0002153)	3.58272384
20	Abnormal respiratory motile cilium morphology (HP:0005938)	3.51931475
21	Abnormal respiratory epithelium morphology (HP:0012253)	3.51931475
22	Infertility (HP:0000789)	3.36540683
23	Nephronophthisis (HP:0000090)	3.30353495
24	Tubulointerstitial nephritis (HP:0001970)	3.29753845
25	Decreased central vision (HP:0007663)	3.29470058
26	Facial shape deformation (HP:0011334)	3.28144505
27	Potter facies (HP:0002009)	3.28144505
28	Postural instability (HP:0002172)	3.17819937
29	Impulsivity (HP:0100710)	3.11261515
30	Asymmetric septal hypertrophy (HP:0001670)	3.07833925
31	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.98854169
32	Type II lissencephaly (HP:0007260)	2.89941679
33	Abnormality of the renal medulla (HP:0100957)	2.83703760
34	Enlarged epiphyses (HP:0010580)	2.82015174
35	Polydipsia (HP:0001959)	2.77603081
36	Abnormal drinking behavior (HP:0030082)	2.77603081
37	Cone-rod dystrophy (HP:0000548)	2.75036395
38	Azoospermia (HP:0000027)	2.74994629
39	Rhinitis (HP:0012384)	2.66312459
40	Abnormal urine output (HP:0012590)	2.56738312
41	Abnormality of the pubic bones (HP:0003172)	2.48011654
42	Abnormal spermatogenesis (HP:0008669)	2.42528003
43	Resting tremor (HP:0002322)	2.41260337
44	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.39547241
45	Polyuria (HP:0000103)	2.35702886
46	Congenital sensorineural hearing impairment (HP:0008527)	2.33867457
47	Renal dysplasia (HP:0000110)	2.33624101
48	Sclerocornea (HP:0000647)	2.30993300
49	Gaze-evoked nystagmus (HP:0000640)	2.28516972
50	Pendular nystagmus (HP:0012043)	2.27105148
51	Truncal obesity (HP:0001956)	2.27048033
52	Hypophosphatemic rickets (HP:0004912)	2.25079716
53	Generalized aminoaciduria (HP:0002909)	2.22893381
54	Abnormality of renal excretion (HP:0011036)	2.22791247
55	Pancreatic cysts (HP:0001737)	2.19145224
56	Pancreatic fibrosis (HP:0100732)	2.18578728
57	Abnormality of potassium homeostasis (HP:0011042)	2.18039113
58	Keratoconus (HP:0000563)	2.13748810
59	Increased corneal curvature (HP:0100692)	2.13748810
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07758499
61	Molar tooth sign on MRI (HP:0002419)	2.05843857
62	Abnormality of midbrain morphology (HP:0002418)	2.05843857
63	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.05666751
64	Macular degeneration (HP:0000608)	2.05358638
65	Congenital stationary night blindness (HP:0007642)	2.02222335
66	Abnormality of the aortic arch (HP:0012303)	2.00465832
67	Stage 5 chronic kidney disease (HP:0003774)	2.00318386
68	Cerebellar dysplasia (HP:0007033)	1.99994967
69	Tubular atrophy (HP:0000092)	1.98985794
70	Nasal polyposis (HP:0100582)	1.98675074
71	Portal hypertension (HP:0001409)	1.98004813
72	Tubulointerstitial abnormality (HP:0001969)	1.96406280
73	Recurrent corneal erosions (HP:0000495)	1.95844246
74	Myokymia (HP:0002411)	1.95102845
75	Amelogenesis imperfecta (HP:0000705)	1.92529476
76	Photophobia (HP:0000613)	1.92325870
77	Bulbous nose (HP:0000414)	1.91905092
78	Scotoma (HP:0000575)	1.91534574
79	Febrile seizures (HP:0002373)	1.87411731
80	Abnormality of the hepatic vasculature (HP:0006707)	1.87271594
81	Abnormality of binocular vision (HP:0011514)	1.87258740
82	Diplopia (HP:0000651)	1.87258740
83	Abnormality of dental color (HP:0011073)	1.87065136
84	Cystic liver disease (HP:0006706)	1.86844363
85	Optic nerve hypoplasia (HP:0000609)	1.84567621
86	Atonic seizures (HP:0010819)	1.78756010
87	Stereotypic behavior (HP:0000733)	1.78404063
88	Horizontal nystagmus (HP:0000666)	1.75144408
89	Bronchiectasis (HP:0002110)	1.72850586
90	Intellectual disability, moderate (HP:0002342)	1.71823696
91	Congenital hepatic fibrosis (HP:0002612)	1.70658431
92	Congenital malformation of the right heart (HP:0011723)	1.70188477
93	Double outlet right ventricle (HP:0001719)	1.70188477
94	Failure to thrive in infancy (HP:0001531)	1.68663968
95	Epiphyseal dysplasia (HP:0002656)	1.66753030
96	Osteomalacia (HP:0002749)	1.66119631
97	Type II diabetes mellitus (HP:0005978)	1.65089436
98	Abolished electroretinogram (ERG) (HP:0000550)	1.64982182
99	Renovascular hypertension (HP:0100817)	1.64718379
100	Hyponatremia (HP:0002902)	1.64428420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.13393501
2	PLK4	5.76705427
3	DDR2	4.00282525
4	FRK	3.57638900
5	TESK1	3.50135264
6	MAP4K2	3.34976124
7	PNCK	2.85097327
8	TRIM28	2.59332262
9	STK38	2.49774062
10	PLK2	2.40620219
11	NTRK3	2.23779940
12	TNIK	2.19232192
13	CAMK1G	2.09475694
14	MUSK	1.88097700
15	BRD4	1.79363094
16	STK38L	1.66688772
17	SIK2	1.66131356
18	PTK2B	1.60498156
19	BMPR1B	1.57310774
20	MAPK15	1.55195219
21	MAP3K4	1.47403952
22	PIK3CG	1.47222965
23	MAP3K9	1.40965370
24	EPHA4	1.34617460
25	PRKD3	1.32490763
26	ADRBK2	1.32345710
27	ACVR1B	1.20610724
28	PDK1	1.17169083
29	PDPK1	1.12907491
30	CASK	1.10275948
31	WNK1	1.09597663
32	MST1R	1.06808253
33	GRK1	0.89918754
34	CDK12	0.87495843
35	NEK6	0.85685537
36	MAPK13	0.84422637
37	STK39	0.81410030
38	CDK7	0.80702009
39	MARK1	0.76224517
40	PRKCG	0.75932648
41	CAMK1D	0.75884975
42	TIE1	0.74220576
43	PRKG1	0.71933138
44	PINK1	0.71530656
45	CDK19	0.70528294
46	LATS1	0.69963580
47	PKN1	0.68548268
48	NTRK2	0.67991471
49	OXSR1	0.67289113
50	PRKCE	0.65927052
51	NUAK1	0.64859321
52	MINK1	0.60488955
53	TNK2	0.56557032
54	CAMK1	0.55475898
55	PRKCZ	0.52295015
56	MARK3	0.51774749
57	FER	0.51693272
58	WNK4	0.51248670
59	MET	0.51247953
60	PRKAA2	0.49622351
61	WNK3	0.46723507
62	GSK3B	0.46460894
63	CDK3	0.45075356
64	RIPK4	0.44173935
65	PRKCB	0.43905220
66	CDK2	0.43453512
67	AKT3	0.42637625
68	MAPK1	0.41827142
69	CAMK2A	0.40510531
70	RPS6KA1	0.40483636
71	DYRK1B	0.39511513
72	UHMK1	0.38272279
73	CHEK1	0.37701015
74	ROCK1	0.36907608
75	SGK1	0.36479994
76	DAPK2	0.36306633
77	CDK1	0.34355216
78	ADRBK1	0.32640633
79	MTOR	0.32512226
80	MAP2K7	0.32398156
81	MAPK8	0.32009260
82	BCKDK	0.31835829
83	MAP2K2	0.31147620
84	TLK1	0.30527383
85	PRKG2	0.29618403
86	MARK2	0.29350155
87	MAPK14	0.28690663
88	PRKACA	0.28490442
89	PRKCA	0.27602307
90	PRKAA1	0.27097384
91	RPS6KA6	0.26246742
92	TGFBR1	0.25238006
93	RPS6KA2	0.25020479
94	NEK2	0.24868293
95	CAMK4	0.23696345
96	PRKACB	0.22003912
97	STK3	0.21045455
98	MAPK10	0.20881430
99	AKT1	0.20214100
100	GRK7	0.18983551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.40260051
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.67289323
3	Olfactory transduction_Homo sapiens_hsa04740	3.40827164
4	Butanoate metabolism_Homo sapiens_hsa00650	3.18124707
5	Taste transduction_Homo sapiens_hsa04742	2.95049683
6	Nicotine addiction_Homo sapiens_hsa05033	2.64191574
7	Morphine addiction_Homo sapiens_hsa05032	2.24598205
8	Phototransduction_Homo sapiens_hsa04744	2.16714041
9	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.12567799
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96342431
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.94605209
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94189236
13	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.80665362
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.80328142
15	GABAergic synapse_Homo sapiens_hsa04727	1.64647034
16	Circadian entrainment_Homo sapiens_hsa04713	1.63471173
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.59342620
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45994646
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.42284966
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.39065098
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34539312
22	Type II diabetes mellitus_Homo sapiens_hsa04930	1.32641277
23	Histidine metabolism_Homo sapiens_hsa00340	1.32441653
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25556341
25	Serotonergic synapse_Homo sapiens_hsa04726	1.24091150
26	ABC transporters_Homo sapiens_hsa02010	1.21526369
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19096943
28	Salivary secretion_Homo sapiens_hsa04970	1.16976714
29	Insulin secretion_Homo sapiens_hsa04911	1.12214713
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12183931
31	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.10235003
32	Cholinergic synapse_Homo sapiens_hsa04725	1.04101077
33	Fatty acid degradation_Homo sapiens_hsa00071	1.01301047
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.00928866
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99555673
36	Basal transcription factors_Homo sapiens_hsa03022	0.98796113
37	cAMP signaling pathway_Homo sapiens_hsa04024	0.97513446
38	Renin-angiotensin system_Homo sapiens_hsa04614	0.96296567
39	Gastric acid secretion_Homo sapiens_hsa04971	0.96206760
40	Retinol metabolism_Homo sapiens_hsa00830	0.95608083
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95473079
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.93233286
43	Oocyte meiosis_Homo sapiens_hsa04114	0.88485232
44	Protein digestion and absorption_Homo sapiens_hsa04974	0.87388915
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86256865
46	Cocaine addiction_Homo sapiens_hsa05030	0.82198000
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.80259370
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.79664292
49	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76867839
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75246982
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73528334
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.71525052
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70906574
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.70176546
55	Renin secretion_Homo sapiens_hsa04924	0.70092861
56	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69689164
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.69129827
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68788609
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68501290
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67984595
61	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.67741112
62	Allograft rejection_Homo sapiens_hsa05330	0.67431763
63	RNA transport_Homo sapiens_hsa03013	0.67304142
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67128916
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.65751007
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.65542684
67	Lysine degradation_Homo sapiens_hsa00310	0.64502127
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64078553
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63627004
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.62373165
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.61930506
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.61653342
73	Pancreatic secretion_Homo sapiens_hsa04972	0.57068864
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56790962
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56479417
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56362550
77	Homologous recombination_Homo sapiens_hsa03440	0.55712915
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51717061
79	Caffeine metabolism_Homo sapiens_hsa00232	0.51440294
80	Bile secretion_Homo sapiens_hsa04976	0.51291803
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.51006321
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49717286
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49396261
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.48595790
85	Purine metabolism_Homo sapiens_hsa00230	0.46725978
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44901891
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43766912
88	Amphetamine addiction_Homo sapiens_hsa05031	0.43347164
89	Long-term depression_Homo sapiens_hsa04730	0.42202080
90	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.40990027
91	Asthma_Homo sapiens_hsa05310	0.40831728
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.39678411
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39546741
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.37348925
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37162939
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35645435
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.35559656
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32518073
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31420928
100	Endocytosis_Homo sapiens_hsa04144	0.31192737

GOLGA2P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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